Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [130]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 24072-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- Rac1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Rac1 antibody (Cat. #24072-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The USP1-WDR48 deubiquitinase complex functions as a molecular switch regulating tumor-associated macrophage activation and anti-tumor response.
Theacrine protects vascular endothelial cells against oxidative damage after ischemic stroke by inhibiting Rac1 and activating Nrf2 pathway.
MALAT1 promotes acetaminophen-induced hepatocyte pyroptosis by stabilizing Rac1 through its interaction with MTDH and the hepatoprotective role of muniziqi saifula.
CRB2 Facilitates Epithelial Ovarian Cancer Progression by Inducing Polarity Changes via Activation of the Wnt/PCP Signalling Pathway.
Exercise-induced musclin enhances efferocytosis via metabolic reprogramming to alleviate periprosthetic joint infection.
Gut microbiota-derived trimethylamine-N-oxide protects pulmonary vascular barrier integrity via Vav guanine nucleotide exchange factor 3 (VAV3)-mediated cytoskeletal remodelling in acute lung injury.
Peptide-Enhanced Bioactive Hydrogel Combined with Photodynamic-Phage Synergistic Antibacterial Therapy System Accelerates Infected Wound Healing.
The Role of SARS1 in Head and Neck Squamous Cell Carcinoma and its Potential as a Diagnostic and Prognostic Biomarker.
Curcumin alleviates lipopolysaccharide-induced alveolar epithelial Glycocalyx damage by modulating the Rac1/NF-κB/HPSE pathway.
Dynamic rigidity changes enable rapid cell migration on soft substrates.
Calreticulin-driven immunogenic cell death promotes osteoclast differentiation and osteoarthritis progression via the LRP1/Rac1 signaling.
Targeting FAM134B-DDX3X axis inhibiting AKT signaling in hepatocellular carcinoma.
Atorvastatin improves spermatogenesis in murine and in vitro human chronic orchitis models through restoring blood-testis barriers.
LncRNA NEAT1 regulation of the miR-101-3p/RAC1 axis affects cervical cancer aerobic glycolysis and progression.
Blockade of ITGA2/3/5 Promotes Adipogenic Differentiation of Human Adipose-derived Mesenchymal Stem Cells.
The STRIPAK complex is required for radial sorting and laminin receptor expression in Schwann cells.
ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity.
C1QL1 regulates auditory nerve fibers growth via ELMO1-DOCK180-RAC1 integrin.
Bioactive vascular buds promote collateral vessel formation by grafting on the artificial vessel walls.
Macropinocytosis and Fast Endophilin-Mediated Endocytosis Mediate Absorption of Garlic Chive-Derived Vesicle-like Nanoparticles in Human Intestinal Epithelial Cells.
Oxyresveratrol suppressed melanogenesis, dendrite formation, and melanosome transport in melanocytes via regulation of the MC1R/cAMP/MITF pathway.
Sodium arsenite induces islets β-cells apoptosis and dysfunction via SET-Rac1-mediated cytoskeleton disturbance.
Dedicator of cytokinesis protein 2 activates the epithelial-mesenchymal transition in renal fibrosis through the Rac1/PI3K/AKT pathway.
IRG1/itaconate enhances efferocytosis by activating Nrf2-TIM4 signaling pathway to alleviate con A induced autoimmune liver injury.
Thymic egress and peripheral T cell homeostasis regulated by Rho GTPase-activating protein 30.
The P2Y13 receptor-mediated microglial morphological transformation through the p38MAPK signaling pathway contributes to central sensitization in a murine model of chronic migraine.
Cardiomyocyte-localized CCDC25 senses NET DNA to promote doxorubicin cardiotoxicity by activating autophagic flux.
Rac1 signaling mediates the protection of apigenin against hepatic lipid accumulation and insulin resistance.
Protein arginine methyltransferase 1 stimulates basal cell proliferation and migration to maintain corneal epithelial homeostasis.
Glioblastoma- derived exosomes (GBM-Exo) regulate microglial M2 polarization via the RAC1/AKT/NRF2 pathway.
Metformin inhibits melanin synthesis and melanosome transfer through the cAMP pathway.
The association and clinicopathological significance of Integrin alphavbeta6 and Rac1 expression in gastric carcinoma.
SOXC Enhances NGN2-Mediated Reprogramming of Glioblastoma Cells Into Neuron-Like Cells by Modulating RhoA and RAC1/CDC42 Pathway Activity.
Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket.
The STRIPAK complex is required for radial sorting and laminin receptor expression in Schwann cells.
Exosomal miR-129-2-3p promotes airway epithelial barrier disruption in PM(2.5)-aggravated asthma.
Arginine methylation-dependent TRIM47 stability mediated by CARM1 promotes the metastasis of hepatocellular carcinoma.
Quantification Quality Control Emerges as a Crucial Factor to Enhance Single-Cell Proteomics Data Analysis.
Spatiotemporal dynamics exhibited by horizontal basal cells reveal a pro-neurogenic pathway during injury-induced olfactory epithelium regeneration.
Sustained exposure to Helicobacter pylori induces immune tolerance by desensitizing TLR6.
TOM40 mediates the effect of TSPO on postpartum depression partially through regulating calcium homeostasis in microglia.
NEDD4L mediates ITGB4 ubiquitination and degradation to suppress esophageal carcinoma progression.
RAC1(high) NK cell-based immunotherapy in hepatocellular carcinoma via STAT3-NKG2D axis.
Potential Involvement of M1 Macrophage and VLA4/VCAM-1 Pathway in the Valvular Damage Due to Rheumatic Heart Disease.
Identification and characterization of RAC1-related immune and prognostic subtypes of hepatocellular carcinoma.
NET1 is a critical regulator of spindle assembly and actin dynamics in mouse oocytes.
Rac1 promotes kidney collecting duct repair by mechanically coupling cell morphology to mitotic entry.
Human Parathyroid Hormone (1-34) accelerates skin wound healing through inducing cell migration via up-regulating the expression of Rac1.
Macropinocytosis inhibits alkaliptosis in pancreatic cancer cells through fatty acid uptake.
Two-polarized roles of transcription factor FOSB in lung cancer progression and prognosis: dependent on p53 status.
PlexinA1 promotes gastric cancer migration through preventing MICAL1 protein ubiquitin/proteasome-mediated degradation in a Rac1-dependent manner.
Vitamin D Receptor Activation Targets ROS-Mediated Crosstalk Between Autophagy and Apoptosis in Hepatocytes in Cholestasic Mice.
Comparing synaptic proteomes across five mouse models for autism reveals converging molecular similarities including deficits in oxidative phosphorylation and Rho GTPase signaling.
Dahuang-Taoren, a botanical drug combination, ameliorates adenomyosis via inhibiting Rho GTPases.
BACH1 promotes lung adenocarcinoma cell metastasis through transcriptional activation of ITGA2.
Pleckstrin homology and RhoGEF domain containing G4 (PLEKHG4) leads to the activation of RhoGTPases promoting the malignant phenotypes of thyroid cancer.
Rhein Inhibited Ferroptosis and EMT to Attenuate Diabetic Nephropathy by Regulating the Rac1/NOX1/β-Catenin Axis.
Guanine nucleotide exchange factor T exerts the cancer-promoting function in cholangiocarcinoma by enhancing the Wnt-GSK-3β-β-catenin cascade via regulation of Rac1/Cdc42.
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition.
ICP4-Associated Activation of Rap1b Facilitates Herpes Simplex Virus Type I (HSV-1) Infection in Human Corneal Epithelial Cells.
Kinesin Family Member C1 Overexpression Exerts Tumor-Promoting Properties in Head and Neck Squamous Cell Carcinoma via the Rac1/Wnt/β-catenin Pathway.
Oral exposure to polystyrene nanoplastics reduced male fertility and even caused male infertility by inducing testicular and sperm toxicities in mice.
Human Umbilical Cord Mesenchymal Stem Cells Improve the Status of Hypoxic/Ischemic Cerebral Palsy Rats by Downregulating NogoA/NgR/Rho Pathway.
RhoGDIα regulates spermatogenesis through Rac1/cofilin/F-actin signaling.
Cell-in-Cell-Mediated Entosis Reveals a Progressive Mechanism in Pancreatic Cancer.
Comprehensive Analysis of MICALL2 Reveals Its Potential Roles in EGFR Stabilization and Ovarian Cancer Cell Invasion.
LncRNA DGCR5-encoded polypeptide RIP aggravates SONFH by repressing nuclear localization of β-catenin in BMSCs.
Inhibition of Cxcr4 Disrupts Mouse Embryonic Palatal Mesenchymal Cell Migration and Induces Cleft Palate Occurrence.
Overexpression of PTPRZ1 Regulates p120/β-Catenin Phosphorylation to Promote Carcinogenesis of Oral Submucous Fibrosis.
Spheroid Formation Enhances the Regenerative Capacity of Nucleus Pulposus Cells via Regulating N-CDH and ITGβ1 Interaction.
Network Pharmacology and Experimental Verification to Explore the Potential Mechanism of Yin-Huo-Tang for Lung Adenocarcinoma Recurrence.
Potential Resistance to Antineoplastic Aminated Fullerenes Mediated by M2-Like Monocyte-Derived Exosomes.
Differential dysregulation of granule subsets in WASH-deficient neutrophil leukocytes resulting in inflammation.
Laminin-511 Activates the Human Induced Pluripotent Stem Cell Survival via α6β1 Integrin-Fyn-RhoA-ROCK Signaling.
DOCK2 regulates antifungal immunity by regulating RAC GTPase activity.
Graphene oxide leads to mitochondrial-dependent apoptosis by activating ROS-p53-mPTP pathway in intestinal cells.
CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.
Damnacanthal isolated from morinda species inhibited ovarian cancer cell proliferation and migration through activating autophagy.
Non-canonical Wnt/calcium signaling is protective against podocyte injury and glomerulosclerosis.
The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling.
Spiropachysine A suppresses hepatocellular carcinoma proliferation by inducing methuosis in vitro and in vivo.
Activation of the NLRP3 inflammasome by RAC1 mediates a new mechanism in diabetic nephropathy.
Klotho functionalization on vascular graft for improved patency and endothelialization.
Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization.
Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer.
High MICAL1 expression correlates with cancer progression and immune infiltration in renal clear cell carcinoma.
Cell-in-cell structure mediates in-cell killing suppressed by CD44.
CUX1 Facilitates the Development of Oncogenic Properties Via Activating Wnt/β-Catenin Signaling Pathway in Glioma.
RhoGDI1-Cdc42 Signaling Is Required for PDGF-BB-Induced Phenotypic Transformation of Vascular Smooth Muscle Cells and Neointima Formation.
Regulation of local GTP availability controls RAC1 activity and cell invasion.
Overexpression of DTL enhances cell motility and promotes tumor metastasis in cervical adenocarcinoma by inducing RAC1-JNK-FOXO1 axis.
33-kDa ANXA3 isoform contributes to hepatocarcinogenesis via modulating ERK, PI3K/Akt-HIF and intrinsic apoptosis pathways.
Salvianolic acid A prevented cerebrovascular endothelial injury caused by acute ischemic stroke through inhibiting the Src signaling pathway.
Three-dimensional cell-culture platform based on hydrogel with tunable microenvironmental properties to improve insulin-secreting function of MIN6 cells.
Loss of QKI in macrophage aggravates inflammatory bowel disease through amplified ROS signaling and microbiota disproportion.
Tumour-derived exosomal lncRNA-SOX2OT promotes bone metastasis of non-small cell lung cancer by targeting the miRNA-194-5p/RAC1 signalling axis in osteoclasts.
Long noncoding RNA EPB41L4A-AS1 functions as an oncogene by regulating the Rho/ROCK pathway in colorectal cancer.
LIM domain-containing 2 (LIMD2) promotes the progress of ovarian cancer via the focal adhesion signaling pathway.
6-Thioguanine Inhibits Herpes Simplex Virus 1 Infection of Eyes.
DOCK7 protects against replication stress by promoting RPA stability on chromatin.
Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis.
RhoG/Rac1 signaling pathway involved in migration and invasion of salivary adenoid cystic carcinoma cells.
Modulation of the Pol II CTD Phosphorylation Code by Rac1 and Cdc42 Small GTPases in Cultured Human Cancer Cells and Its Implication for Developing a Synthetic-Lethal Cancer Therapy.
Oxidation of Reduced Graphene Oxide via Cellular Redox Signaling Modulates Actin-Mediated Neurotransmission.
RhoA/ROCK Pathway Activation is Regulated by AT1 Receptor and Participates in Smooth Muscle Migration and Dedifferentiation via Promoting Actin Cytoskeleton Polymerization.
Plastin 1 drives metastasis of colorectal cancer through the IQGAP1/Rac1/ERK pathway.
TNFAIP8 promotes AML chemoresistance by activating ERK signaling pathway through interaction with Rac1.
Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate.
YAP promotes multi-drug resistance and inhibits autophagy-related cell death in hepatocellular carcinoma via the RAC1-ROS-mTOR pathway.
Proteomics Analysis Identifies IRSp53 and Fascin as Critical for PRV Egress and Direct Cell-Cell Transmission.
CSTF2-Induced Shortening of the RAC1 3'UTR Promotes the Pathogenesis of Urothelial Carcinoma of the Bladder.
Annexin A5 regulates hepatocarcinoma malignancy via CRKI/II-DOCK180-RAC1 integrin and MEK-ERK pathways.
PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF‑R.
Silencing Ras-Related C3 Botulinum Toxin Substrate 1 Inhibits Growth and Migration of Hypopharyngeal Squamous Cell Carcinoma via the P38 Mitogen-Activated Protein Kinase Signaling Pathway.
Combination antitumor immunotherapy with VEGF and PIGF siRNA via systemic delivery of multi-functionalized nanoparticles to tumor-associated macrophages and breast cancer cells.
Graphene Oxide Induced Perturbation to Plasma Membrane and Cytoskeletal Meshwork Sensitize Cancer Cells to Chemotherapeutic Agents.
Nicotine facilitates VSMC dysfunction through a miR-200b/RhoGDIA/cytoskeleton module.
Cathelicidin-WA Improves Intestinal Epithelial Barrier Function and Enhances Host Defense against Enterohemorrhagic Escherichia coli O157:H7 Infection.
A taspine derivative supresses Caco-2 cell growth by competitively targeting EphrinB2 and regulating its pathway.
Dihydroartemisinin suppresses pancreatic cancer cells via a microRNA-mRNA regulatory network.
Metastasis suppressor 1 regulates neurite outgrowth in primary neuron cultures.
Upregulated TRIO expression correlates with a malignant phenotype in human hepatocellular carcinoma.
NADPH oxidase-derived production of reactive oxygen species is involved in learning and memory impairments in 16-month-old female rats.
Sanguinarine inhibits Rac1b-rendered cell survival enhancement by promoting apoptosis and blocking proliferation.
Screening key microRNAs for castration-resistant prostate cancer based on miRNA/mRNA functional synergistic network.
Baculovirus induces host cell aggregation via a Rho/Rok-dependent mechanism.
Protective effects of ginsenoside Rg1 on chronic restraint stress induced learning and memory impairments in male mice.
Elevated Orai1 expression mediates tumor-promoting intracellular Ca2+ oscillations in human esophageal squamous cell carcinoma.
RACK1 promotes the proliferation, migration and invasion capacity of mouse hepatocellular carcinoma cell line in vitro probably by PI3K/Rac1 signaling pathway.
The phosphodiesterase-5 inhibitor vardenafil reduces oxidative stress while reversing pulmonary arterial hypertension.
Han D, Wang L, Jiang S, Su P, Chen B, Zhao W, Chen T, Zhang N, Wang X, Liang Y, Li Y, Li C, Chen X, Luo D, Yang Q
Cell death and differentiation 2026 Jan;33(1):92-110
Cell death and differentiation 2026 Jan;33(1):92-110
Theacrine protects vascular endothelial cells against oxidative damage after ischemic stroke by inhibiting Rac1 and activating Nrf2 pathway.
Zhang Y, Li Y, Li X, Liao P, Chen W, Feng Y, Zhang X, Chen Y, Nan L, Li H, Yan G
International immunopharmacology 2026 Jan 1;168(Pt 2):115951
International immunopharmacology 2026 Jan 1;168(Pt 2):115951
MALAT1 promotes acetaminophen-induced hepatocyte pyroptosis by stabilizing Rac1 through its interaction with MTDH and the hepatoprotective role of muniziqi saifula.
Kuerban Y, Gul A, Wusiman Z, Huo S, Ruermaiti M, Wahefu A, Wushouer S, Kamili M, Aierken A, Li Z, Talifu A
Molecular and cellular biochemistry 2026 Apr;481(4):1745-1759
Molecular and cellular biochemistry 2026 Apr;481(4):1745-1759
CRB2 Facilitates Epithelial Ovarian Cancer Progression by Inducing Polarity Changes via Activation of the Wnt/PCP Signalling Pathway.
Tao C, Li S, Sun D, Zhou J, Chen Y, Zhang R, Ni X
Journal of cellular and molecular medicine 2026 Apr;30(7):e71124
Journal of cellular and molecular medicine 2026 Apr;30(7):e71124
Exercise-induced musclin enhances efferocytosis via metabolic reprogramming to alleviate periprosthetic joint infection.
Fu Z, Wu J, Zhang S, Jiao J, Hong Q, Wang Y, Zheng L, Qu X, Yue B
Journal of sport and health science 2026 Apr 29;:101143
Journal of sport and health science 2026 Apr 29;:101143
Gut microbiota-derived trimethylamine-N-oxide protects pulmonary vascular barrier integrity via Vav guanine nucleotide exchange factor 3 (VAV3)-mediated cytoskeletal remodelling in acute lung injury.
Wang X, Zeng W, Bai Q, Zhong K, Luo Q, Deng J, Cen C, Wang K, Li R, Li J, Zhang J, Ye T, Fang N, Chen X, Wang T
British journal of pharmacology 2026 Apr 23;
British journal of pharmacology 2026 Apr 23;
Peptide-Enhanced Bioactive Hydrogel Combined with Photodynamic-Phage Synergistic Antibacterial Therapy System Accelerates Infected Wound Healing.
Quan L, Xin Y, Zhang Z, Zhou C, Ao Q
Advanced healthcare materials 2025 Sep;14(24):e2500875
Advanced healthcare materials 2025 Sep;14(24):e2500875
The Role of SARS1 in Head and Neck Squamous Cell Carcinoma and its Potential as a Diagnostic and Prognostic Biomarker.
Zhang Q, Liu M, Lv J, Peng Y, Fu D, He Y
International dental journal 2025 Oct;75(5):100876
International dental journal 2025 Oct;75(5):100876
Curcumin alleviates lipopolysaccharide-induced alveolar epithelial Glycocalyx damage by modulating the Rac1/NF-κB/HPSE pathway.
Xu W, Ou D, Zhao Y, Liu Y, Yan P, Li S, Sun Q, Zhang X, Liu H, Huang J, Fang Y
Cellular signalling 2025 Oct;134:111909
Cellular signalling 2025 Oct;134:111909
Dynamic rigidity changes enable rapid cell migration on soft substrates.
Yang J, Zhang Y, Wang S, Wang P, Dong L, Li L, Cheng Y, Huang X, Xue B, Wang W, Jiang C, Gu X, Cao Y, Wei Q
Nature communications 2025 Oct 2;16(1):8793
Nature communications 2025 Oct 2;16(1):8793
Calreticulin-driven immunogenic cell death promotes osteoclast differentiation and osteoarthritis progression via the LRP1/Rac1 signaling.
Ma Q, Lan Z, Yang Y, Sun R, Xue D, Lin X, Su Y, Ma L, Hu Z, Wu G, He X, Tian K, Jin Q
International immunopharmacology 2025 Oct 10;163:115277
International immunopharmacology 2025 Oct 10;163:115277
Targeting FAM134B-DDX3X axis inhibiting AKT signaling in hepatocellular carcinoma.
Mo J, Su C, Liu Q, Li P, Xu L, Long X, Liang H, Zhang B, Chen J
Cell death & disease 2025 Nov 6;16(1):797
Cell death & disease 2025 Nov 6;16(1):797
Atorvastatin improves spermatogenesis in murine and in vitro human chronic orchitis models through restoring blood-testis barriers.
Ma L, Chen J, Li Q, Zhu Y, Ren S, Song K, Yao Z, Yang X, Zheng Y, Liu Z, Wang Z, Miao K, Chen S, Zhao XY, Luo F
Cell death discovery 2025 Nov 6;11(1):505
Cell death discovery 2025 Nov 6;11(1):505
LncRNA NEAT1 regulation of the miR-101-3p/RAC1 axis affects cervical cancer aerobic glycolysis and progression.
Cao L, Abudureheman W, Shen G, Ouyang Y, Yang W, Zhao Q, Lu T, Lin C
Scientific reports 2025 May 20;15(1):17436
Scientific reports 2025 May 20;15(1):17436
Blockade of ITGA2/3/5 Promotes Adipogenic Differentiation of Human Adipose-derived Mesenchymal Stem Cells.
Li Y, Wang W, Liu Z, Liu G, Li X
Cell biochemistry and biophysics 2025 Mar;83(1):1105-1111
Cell biochemistry and biophysics 2025 Mar;83(1):1105-1111
The STRIPAK complex is required for radial sorting and laminin receptor expression in Schwann cells.
Weaver MR, Shkoruta D, Pellegatta M, Berti C, Palmisano M, Ferguson S, Hurley E, French J, Patel S, Belin S, Selbach M, Paul FE, Sim F, Poitelon Y, Feltri ML
Cell reports 2025 Mar 25;44(3):115401
Cell reports 2025 Mar 25;44(3):115401
ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity.
Zhang T, Wang Y, Nie X, Chen X, Jin Y, Sun L, Yang R, Wang J, Xu W, Song T, Xie W, Chen X, Li C, Zhou J, Wu S, Li Y, Li T
Cell reports 2025 Mar 25;44(3):115397
Cell reports 2025 Mar 25;44(3):115397
C1QL1 regulates auditory nerve fibers growth via ELMO1-DOCK180-RAC1 integrin.
Chen M, Qi Y, Gong S
Acta oto-laryngologica 2025 Jun;145(6):476-482
Acta oto-laryngologica 2025 Jun;145(6):476-482
Bioactive vascular buds promote collateral vessel formation by grafting on the artificial vessel walls.
Yang Y, Qiu Y, Xu S, Gao H, Wang C, Huang H, Yang Z, Chen X, Zhao F
Bioactive materials 2025 Jul;49:564-575
Bioactive materials 2025 Jul;49:564-575
Macropinocytosis and Fast Endophilin-Mediated Endocytosis Mediate Absorption of Garlic Chive-Derived Vesicle-like Nanoparticles in Human Intestinal Epithelial Cells.
Nguyen PL, Liu B, Zhang S, Hao J, Yu J
Molecular pharmaceutics 2025 Jul 7;22(7):3935-3948
Molecular pharmaceutics 2025 Jul 7;22(7):3935-3948
Oxyresveratrol suppressed melanogenesis, dendrite formation, and melanosome transport in melanocytes via regulation of the MC1R/cAMP/MITF pathway.
Zhang J, Liu S, Guo W, Huang Y, Li N
Scientific reports 2025 Jul 1;15(1):20400
Scientific reports 2025 Jul 1;15(1):20400
Sodium arsenite induces islets β-cells apoptosis and dysfunction via SET-Rac1-mediated cytoskeleton disturbance.
Qiu T, Zhi Y, Zhang J, Wang N, Yao X, Yang G, Jiang L, Lv L, Sun X
Ecotoxicology and environmental safety 2025 Jan 1;289:117641
Ecotoxicology and environmental safety 2025 Jan 1;289:117641
Dedicator of cytokinesis protein 2 activates the epithelial-mesenchymal transition in renal fibrosis through the Rac1/PI3K/AKT pathway.
Jia Y, Sun J, Chen S, Bian Y, Jiang A, Liang H, Du X
Biochimica et biophysica acta. Molecular cell research 2025 Feb;1872(2):119894
Biochimica et biophysica acta. Molecular cell research 2025 Feb;1872(2):119894
IRG1/itaconate enhances efferocytosis by activating Nrf2-TIM4 signaling pathway to alleviate con A induced autoimmune liver injury.
Zeng L, Wang Y, Huang Y, Yang W, Zhou P, Wan Y, Tao K, Li R
Cell communication and signaling : CCS 2025 Feb 5;23(1):63
Cell communication and signaling : CCS 2025 Feb 5;23(1):63
Thymic egress and peripheral T cell homeostasis regulated by Rho GTPase-activating protein 30.
Zhang H, Guo Z, Yi J, Wu J, Wang Y, Ren T, Zhang Y, Zhao H, Wu N, Wei G, Zhang D
Cell death and differentiation 2025 Dec;32(12):2294-2308
Cell death and differentiation 2025 Dec;32(12):2294-2308
The P2Y13 receptor-mediated microglial morphological transformation through the p38MAPK signaling pathway contributes to central sensitization in a murine model of chronic migraine.
Yang Y, Sun S, Qin P, Sun Y, Li H, Wang D, He X, Ge Z, Fan Z, Zhang J, Sun S
The journal of headache and pain 2025 Dec 15;27(1):8
The journal of headache and pain 2025 Dec 15;27(1):8
Cardiomyocyte-localized CCDC25 senses NET DNA to promote doxorubicin cardiotoxicity by activating autophagic flux.
Nie M, Lei D, Liu Z, Zeng K, Liang X, Huang P, Wang Y, Sun P, Yang H, Liu P, Nie R, Huang S, Song E, Jiang W, Li Z, Yang Y, Xia Y, Yang L
Nature cancer 2025 Aug;6(8):1400-1418
Nature cancer 2025 Aug;6(8):1400-1418
Rac1 signaling mediates the protection of apigenin against hepatic lipid accumulation and insulin resistance.
Hsu MC, Guo BC, Chen CH, Hu PA, Chen WH, Lee TS
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Aug;189:118265
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Aug;189:118265
Protein arginine methyltransferase 1 stimulates basal cell proliferation and migration to maintain corneal epithelial homeostasis.
Yang J, Hu M, Yang M, Ni H, Zhou J, Li D, Ran J, Liu M
Cell death discovery 2025 Aug 15;11(1):385
Cell death discovery 2025 Aug 15;11(1):385
Glioblastoma- derived exosomes (GBM-Exo) regulate microglial M2 polarization via the RAC1/AKT/NRF2 pathway.
Wu Q, Chen S, Xie X, Yan H, Feng X, Su G, Zhang Z
Journal of neuro-oncology 2025 Apr;172(2):447-460
Journal of neuro-oncology 2025 Apr;172(2):447-460
Metformin inhibits melanin synthesis and melanosome transfer through the cAMP pathway.
Liu X, Sun X, Liu Y, Wang W, Yang H, Ge Y, Yang Y, Chen X, Lin T
Scientific reports 2025 Apr 3;15(1):11442
Scientific reports 2025 Apr 3;15(1):11442
The association and clinicopathological significance of Integrin alphavbeta6 and Rac1 expression in gastric carcinoma.
Yu J, Jia W, Liu Q, Yuan A, Jia Z, Sun Y, Li Z, Cao S
Frontiers in oncology 2024;14:1347270
Frontiers in oncology 2024;14:1347270
SOXC Enhances NGN2-Mediated Reprogramming of Glioblastoma Cells Into Neuron-Like Cells by Modulating RhoA and RAC1/CDC42 Pathway Activity.
Yang J, Zhu X, Wang F, Chen Z, Zhang Y, Chen J, Ni H, Zhang CL, Zhuge Q
CNS neuroscience & therapeutics 2024 Oct;30(10):e70075
CNS neuroscience & therapeutics 2024 Oct;30(10):e70075
Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket.
Morstein J, Bowcut V, Fernando M, Yang Y, Zhu L, Jenkins ML, Evans JT, Guiley KZ, Peacock DM, Krahnke S, Lin Z, Taran KA, Huang BJ, Stephen AG, Burke JE, Lightstone FC, Shokat KM
Cell 2024 Oct 31;187(22):6379-6392.e17
Cell 2024 Oct 31;187(22):6379-6392.e17
The STRIPAK complex is required for radial sorting and laminin receptor expression in Schwann cells.
Weaver MR, Shkoruta D, Pellegatta M, Berti C, Palmisano M, Ferguson S, Hurley E, French J, Patel S, Belin S, Selbach M, Paul FE, Sim F, Poitelon Y, Feltri ML
bioRxiv : the preprint server for biology 2024 Oct 31;
bioRxiv : the preprint server for biology 2024 Oct 31;
Exosomal miR-129-2-3p promotes airway epithelial barrier disruption in PM(2.5)-aggravated asthma.
Wang C, Niu Z, Zhang Y, Liu N, Ji X, Tian J, Guan L, Shi D, Zheng H, Gao Y, Zhao L, Zhang W, Zhang Z
Journal of environmental management 2024 Nov;370:123053
Journal of environmental management 2024 Nov;370:123053
Arginine methylation-dependent TRIM47 stability mediated by CARM1 promotes the metastasis of hepatocellular carcinoma.
Tang Y, Meng X, Luo X, Yao W, Tian L, Zhang Z, Zhao Y, Xiao J, Zhu H, Hu J
Cell death discovery 2024 Nov 20;10(1):477
Cell death discovery 2024 Nov 20;10(1):477
Quantification Quality Control Emerges as a Crucial Factor to Enhance Single-Cell Proteomics Data Analysis.
Yu SH, Chen SC, Wu PS, Kuo PI, Chen TA, Lee HY, Lin MH
Molecular & cellular proteomics : MCP 2024 May;23(5):100768
Molecular & cellular proteomics : MCP 2024 May;23(5):100768
Spatiotemporal dynamics exhibited by horizontal basal cells reveal a pro-neurogenic pathway during injury-induced olfactory epithelium regeneration.
Louie JD, Barrios-Camacho CM, Bromberg BH, Hintschich CA, Schwob JE
iScience 2024 May 17;27(5):109600
iScience 2024 May 17;27(5):109600
Sustained exposure to Helicobacter pylori induces immune tolerance by desensitizing TLR6.
Zhang X, He Y, Zhang X, Fu B, Song Z, Wang L, Fu R, Lu X, Xing J, Lv J, Guo M, Huo X, Liu X, Lu J, Du X, Ge Z, Chen Z, Li C
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2024 Mar;27(2):324-342
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2024 Mar;27(2):324-342
TOM40 mediates the effect of TSPO on postpartum depression partially through regulating calcium homeostasis in microglia.
Zhai DS, Wang XS, Yang L, Jiang YL, Jin YC, Yan YX, Song DK, Zhang K, Han ZK, Liu MY, Wu YM, Ma X, Qi JY, Yang F, Tian F, Li XB, Liu SB
Journal of affective disorders 2024 Mar 1;348:283-296
Journal of affective disorders 2024 Mar 1;348:283-296
NEDD4L mediates ITGB4 ubiquitination and degradation to suppress esophageal carcinoma progression.
Shi Y, Fang N, Wu Y, Xu H, Ning A, Zhang W, Liu Y, Tao X, Chen Q, Tian T, Zhang L, Chu M, Cui J
Cell communication and signaling : CCS 2024 Jun 3;22(1):302
Cell communication and signaling : CCS 2024 Jun 3;22(1):302
RAC1(high) NK cell-based immunotherapy in hepatocellular carcinoma via STAT3-NKG2D axis.
Shi X, Chen W, Yin Y, Cao H, Wang X, Jiang W, Li Q, Li X, Yu Y, Wang X
Cancer letters 2024 Jun 28;592:216909
Cancer letters 2024 Jun 28;592:216909
Potential Involvement of M1 Macrophage and VLA4/VCAM-1 Pathway in the Valvular Damage Due to Rheumatic Heart Disease.
Xian S, Li Y, Bai L, Tang S, Meng Z, Wen H, Huang F, Zeng Z
Frontiers in bioscience (Landmark edition) 2024 Jun 18;29(6):219
Frontiers in bioscience (Landmark edition) 2024 Jun 18;29(6):219
Identification and characterization of RAC1-related immune and prognostic subtypes of hepatocellular carcinoma.
Wang W, Xia H, Feng P, Dai B
The journal of gene medicine 2024 Jul;26(7):e3719
The journal of gene medicine 2024 Jul;26(7):e3719
NET1 is a critical regulator of spindle assembly and actin dynamics in mouse oocytes.
Wang S, Wu X, Zhang M, Chang S, Guo Y, Song S, Dai S, Wu K, Zeng S
Reproductive biology and endocrinology : RB&E 2024 Jan 2;22(1):5
Reproductive biology and endocrinology : RB&E 2024 Jan 2;22(1):5
Rac1 promotes kidney collecting duct repair by mechanically coupling cell morphology to mitotic entry.
Bock F, Dong X, Li S, Viquez OM, Sha E, Tantengco M, Hennen EM, Plosa E, Ramezani A, Brown KL, Whang YM, Terker AS, Arroyo JP, Harrison DG, Fogo A, Brakebusch CH, Pozzi A, Zent R
Science advances 2024 Feb 9;10(6):eadi7840
Science advances 2024 Feb 9;10(6):eadi7840
Human Parathyroid Hormone (1-34) accelerates skin wound healing through inducing cell migration via up-regulating the expression of Rac1.
Sun Q, Zhou L, Yu Z, Zhang J, Zhang C, Pi H
Cell division 2024 Feb 12;19(1):4
Cell division 2024 Feb 12;19(1):4
Macropinocytosis inhibits alkaliptosis in pancreatic cancer cells through fatty acid uptake.
Chen F, Tang H, Lin J, Xiang L, Lu Y, Kang R, Tang D, Liu J
Carcinogenesis 2024 Dec 30;45(12):953-964
Carcinogenesis 2024 Dec 30;45(12):953-964
Two-polarized roles of transcription factor FOSB in lung cancer progression and prognosis: dependent on p53 status.
Zhang H, Zhang G, Xiao M, Cui S, Jin C, Yang J, Wu S, Lu X
Journal of experimental & clinical cancer research : CR 2024 Aug 21;43(1):237
Journal of experimental & clinical cancer research : CR 2024 Aug 21;43(1):237
PlexinA1 promotes gastric cancer migration through preventing MICAL1 protein ubiquitin/proteasome-mediated degradation in a Rac1-dependent manner.
Ye F, Xia T, Zhao M, Zhao W, Min P, Wang Y, Wang Q, Zhang Y, Du J
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167124
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167124
Vitamin D Receptor Activation Targets ROS-Mediated Crosstalk Between Autophagy and Apoptosis in Hepatocytes in Cholestasic Mice.
Zheng Z, Xie J, Ma L, Hao Z, Zhang W, Li L
Cellular and molecular gastroenterology and hepatology 2023;15(4):887-901
Cellular and molecular gastroenterology and hepatology 2023;15(4):887-901
Comparing synaptic proteomes across five mouse models for autism reveals converging molecular similarities including deficits in oxidative phosphorylation and Rho GTPase signaling.
Carbonell AU, Freire-Cobo C, Deyneko IV, Dobariya S, Erdjument-Bromage H, Clipperton-Allen AE, Page DT, Neubert TA, Jordan BA
Frontiers in aging neuroscience 2023;15:1152562
Frontiers in aging neuroscience 2023;15:1152562
Dahuang-Taoren, a botanical drug combination, ameliorates adenomyosis via inhibiting Rho GTPases.
Lei Y, Fu X, Chen M, Yi Y, Mao P, Peng L, Qu Z
Frontiers in pharmacology 2023;14:1089004
Frontiers in pharmacology 2023;14:1089004
BACH1 promotes lung adenocarcinoma cell metastasis through transcriptional activation of ITGA2.
Chen Y, Jin L, Ma Y, Liu Y, Zhu Q, Huang Y, Feng W
Cancer science 2023 Sep;114(9):3568-3582
Cancer science 2023 Sep;114(9):3568-3582
Pleckstrin homology and RhoGEF domain containing G4 (PLEKHG4) leads to the activation of RhoGTPases promoting the malignant phenotypes of thyroid cancer.
Yuan Q, Fan Y, Liu Z, Wang X, Jia M, Dong Y, Geng Z, Zheng J, Lu X
Apoptosis : an international journal on programmed cell death 2023 Oct;28(9-10):1315-1331
Apoptosis : an international journal on programmed cell death 2023 Oct;28(9-10):1315-1331
Rhein Inhibited Ferroptosis and EMT to Attenuate Diabetic Nephropathy by Regulating the Rac1/NOX1/β-Catenin Axis.
Xiong D, Hu W, Han X, Cai Y
Frontiers in bioscience (Landmark edition) 2023 May 25;28(5):100
Frontiers in bioscience (Landmark edition) 2023 May 25;28(5):100
Guanine nucleotide exchange factor T exerts the cancer-promoting function in cholangiocarcinoma by enhancing the Wnt-GSK-3β-β-catenin cascade via regulation of Rac1/Cdc42.
Wang X, Zhang X, Sun J, Sun Y, Zhang Y, He L, Wang P, Li F, Sun C
Toxicology and applied pharmacology 2023 May 15;467:116492
Toxicology and applied pharmacology 2023 May 15;467:116492
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition.
Chu Q, An J, Liu P, Song Y, Zhai X, Yang R, Niu J, Yang C, Li B
The Journal of experimental medicine 2023 Mar 6;220(3)
The Journal of experimental medicine 2023 Mar 6;220(3)
ICP4-Associated Activation of Rap1b Facilitates Herpes Simplex Virus Type I (HSV-1) Infection in Human Corneal Epithelial Cells.
Zhang B, Ding J, Ma Z
Viruses 2023 Jun 27;15(7)
Viruses 2023 Jun 27;15(7)
Kinesin Family Member C1 Overexpression Exerts Tumor-Promoting Properties in Head and Neck Squamous Cell Carcinoma via the Rac1/Wnt/β-catenin Pathway.
Yu BY, Shi LG, Jiang C, Wang GK, Liu J, Wu TY
Laboratory investigation; a journal of technical methods and pathology 2023 Jul;103(7):100134
Laboratory investigation; a journal of technical methods and pathology 2023 Jul;103(7):100134
Oral exposure to polystyrene nanoplastics reduced male fertility and even caused male infertility by inducing testicular and sperm toxicities in mice.
Xu W, Yuan Y, Tian Y, Cheng C, Chen Y, Zeng L, Yuan Y, Li D, Zheng L, Luo T
Journal of hazardous materials 2023 Jul 15;454:131470
Journal of hazardous materials 2023 Jul 15;454:131470
Human Umbilical Cord Mesenchymal Stem Cells Improve the Status of Hypoxic/Ischemic Cerebral Palsy Rats by Downregulating NogoA/NgR/Rho Pathway.
Luo Y, Qu J, He Z, Zhang M, Zou Z, Li L, Zhang Y, Ye J
Cell transplantation 2023 Jan-Dec;32:9636897231210069
Cell transplantation 2023 Jan-Dec;32:9636897231210069
RhoGDIα regulates spermatogenesis through Rac1/cofilin/F-actin signaling.
Zhu H, Wen Z, Zhang A, Liu D, Wang H, Cheng Y, Yang X, Xiao Y, Li J, Sun D, Wu B, Gao J
Communications biology 2023 Feb 23;6(1):214
Communications biology 2023 Feb 23;6(1):214
Cell-in-Cell-Mediated Entosis Reveals a Progressive Mechanism in Pancreatic Cancer.
Song J, Xu R, Zhang H, Xue X, Ruze R, Chen Y, Yin X, Wang C, Zhao Y
Gastroenterology 2023 Dec;165(6):1505-1521.e20
Gastroenterology 2023 Dec;165(6):1505-1521.e20
Comprehensive Analysis of MICALL2 Reveals Its Potential Roles in EGFR Stabilization and Ovarian Cancer Cell Invasion.
Xia T, Ye F, Zhao W, Min P, Qi C, Wang Q, Zhao M, Zhang Y, Du J
International journal of molecular sciences 2023 Dec 30;25(1)
International journal of molecular sciences 2023 Dec 30;25(1)
LncRNA DGCR5-encoded polypeptide RIP aggravates SONFH by repressing nuclear localization of β-catenin in BMSCs.
Jiang W, Chen Y, Sun M, Huang X, Zhang H, Fu Z, Wang J, Zhang S, Lian C, Tang B, Xiang D, Wang Y, Zhang Y, Jian C, Yang C, Zhang J, Zhang D, Chen T, Zhang J
Cell reports 2023 Aug 29;42(8):112969
Cell reports 2023 Aug 29;42(8):112969
Inhibition of Cxcr4 Disrupts Mouse Embryonic Palatal Mesenchymal Cell Migration and Induces Cleft Palate Occurrence.
Zheng X, Zhao X, Wang Y, Chen J, Wang X, Peng X, Ma L, Du J
International journal of molecular sciences 2023 Aug 13;24(16)
International journal of molecular sciences 2023 Aug 13;24(16)
Overexpression of PTPRZ1 Regulates p120/β-Catenin Phosphorylation to Promote Carcinogenesis of Oral Submucous Fibrosis.
Ma L, Shen T, Peng H, Wu J, Wang W, Gao X
Journal of oncology 2022;2022:2352360
Journal of oncology 2022;2022:2352360
Spheroid Formation Enhances the Regenerative Capacity of Nucleus Pulposus Cells via Regulating N-CDH and ITGβ1 Interaction.
Wang Y, Wang H, Zhuo Y, Hu Y, Li X, Xu Y, Sun B, Liu M, Zou L, Liu L, Luo L, Zhao C, Li P, Zhou Q
International journal of biological sciences 2022;18(9):3676-3696
International journal of biological sciences 2022;18(9):3676-3696
Network Pharmacology and Experimental Verification to Explore the Potential Mechanism of Yin-Huo-Tang for Lung Adenocarcinoma Recurrence.
Liu D, Lin S, Li Y, Zhou T, Hu K, Li Q
Drug design, development and therapy 2022;16:375-395
Drug design, development and therapy 2022;16:375-395
Potential Resistance to Antineoplastic Aminated Fullerenes Mediated by M2-Like Monocyte-Derived Exosomes.
Huo J, Zhou W, Liu Y, Yang S, Li J, Wang C
Frontiers in oncology 2022;12:779939
Frontiers in oncology 2022;12:779939
Differential dysregulation of granule subsets in WASH-deficient neutrophil leukocytes resulting in inflammation.
Johnson JL, Meneses-Salas E, Ramadass M, Monfregola J, Rahman F, Carvalho Gontijo R, Kiosses WB, Pestonjamasp K, Allen D, Zhang J, Osborne DG, Zhu YP, Wineinger N, Askari K, Chen D, Yu J, Henderson SC, Hedrick CC, Ursini MV, Grinstein S, Billadeau DD, Catz SD
Nature communications 2022 Sep 21;13(1):5529
Nature communications 2022 Sep 21;13(1):5529
Laminin-511 Activates the Human Induced Pluripotent Stem Cell Survival via α6β1 Integrin-Fyn-RhoA-ROCK Signaling.
Nakashima Y, Tsukahara M
Stem cells and development 2022 Nov;31(21-22):706-719
Stem cells and development 2022 Nov;31(21-22):706-719
DOCK2 regulates antifungal immunity by regulating RAC GTPase activity.
Ma X, Tan X, Yu B, Sun W, Wang H, Hu H, Du Y, He R, Gao R, Peng Q, Cui Z, Pan T, Feng X, Wang J, Xu C, Zhu B, Liu W, Wang C
Cellular & molecular immunology 2022 May;19(5):602-618
Cellular & molecular immunology 2022 May;19(5):602-618
Graphene oxide leads to mitochondrial-dependent apoptosis by activating ROS-p53-mPTP pathway in intestinal cells.
Feng W, Wang J, Li B, Liu Y, Xu D, Cheng K, Zhuang J
The international journal of biochemistry & cell biology 2022 May;146:106206
The international journal of biochemistry & cell biology 2022 May;146:106206
CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.
Wang Y, Jin C, Tian H, Xu J, Chen J, Hu S, Li Q, Lu L, Ou Q, Xu GT, Cui H
Experimental eye research 2022 Jun;219:108939
Experimental eye research 2022 Jun;219:108939
Damnacanthal isolated from morinda species inhibited ovarian cancer cell proliferation and migration through activating autophagy.
Li R, Li H, Lan J, Yang D, Lin X, Xu H, Han B, Yang M, Su B, Liu F, Jiang W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154084
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154084
Non-canonical Wnt/calcium signaling is protective against podocyte injury and glomerulosclerosis.
Zhou D, Wang Y, Gui Y, Fu H, Zhou S, Wang Y, Bastacky SI, Stolz DB, Liu Y
Kidney international 2022 Jul;102(1):96-107
Kidney international 2022 Jul;102(1):96-107
The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling.
Ma X, Ma X, Zhu L, Zhao Y, Chen M, Li T, Lin Y, Ma D, Sun C, Han L
Oncogenesis 2022 Jul 20;11(1):40
Oncogenesis 2022 Jul 20;11(1):40
Spiropachysine A suppresses hepatocellular carcinoma proliferation by inducing methuosis in vitro and in vivo.
Fang Y, Zhong T, Yang L, Luo F, Li Q, Wang D, Li Q, Fan Y, Yang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul 20;102:154151
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul 20;102:154151
Activation of the NLRP3 inflammasome by RAC1 mediates a new mechanism in diabetic nephropathy.
Ying C, Zhou Z, Dai J, Wang M, Xiang J, Sun D, Zhou X
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022 Feb;71(2):191-204
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022 Feb;71(2):191-204
Klotho functionalization on vascular graft for improved patency and endothelialization.
Zhao P, Fang Q, Gao D, Wang Q, Cheng Y, Ao Q, Wang X, Tian X, Zhang Y, Tong H, Yan N, Hu X, Fan J
Biomaterials advances 2022 Feb;133:112630
Biomaterials advances 2022 Feb;133:112630
Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization.
Zhang B, Fan M, Fan J, Luo Y, Wang J, Wang Y, Liu B, Sun Y, Zhao Q, Hiscox JA, Nan Y, Zhou EM
Microbiology spectrum 2022 Feb 23;10(1):e0226521
Microbiology spectrum 2022 Feb 23;10(1):e0226521
Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer.
Liu J, Zhang C, Zhang T, Chang CY, Wang J, Bazile L, Zhang L, Haffty BG, Hu W, Feng Z
Nature metabolism 2022 Dec;4(12):1830-1846
Nature metabolism 2022 Dec;4(12):1830-1846
High MICAL1 expression correlates with cancer progression and immune infiltration in renal clear cell carcinoma.
Yang Y, Ye F, Xia T, Wang Q, Du J
BMC cancer 2022 Dec 27;22(1):1355
BMC cancer 2022 Dec 27;22(1):1355
Cell-in-cell structure mediates in-cell killing suppressed by CD44.
Su Y, Huang H, Luo T, Zheng Y, Fan J, Ren H, Tang M, Niu Z, Wang C, Wang Y, Zhang Z, Liang J, Ruan B, Gao L, Chen Z, Melino G, Wang X, Sun Q
Cell discovery 2022 Apr 19;8(1):35
Cell discovery 2022 Apr 19;8(1):35
CUX1 Facilitates the Development of Oncogenic Properties Via Activating Wnt/β-Catenin Signaling Pathway in Glioma.
Feng F, Zhao Z, Zhou Y, Cheng Y, Wu X, Heng X
Frontiers in molecular biosciences 2021;8:705008
Frontiers in molecular biosciences 2021;8:705008
RhoGDI1-Cdc42 Signaling Is Required for PDGF-BB-Induced Phenotypic Transformation of Vascular Smooth Muscle Cells and Neointima Formation.
Qi Y, Liang X, Guan H, Sun J, Yao W
Biomedicines 2021 Sep 6;9(9)
Biomedicines 2021 Sep 6;9(9)
Regulation of local GTP availability controls RAC1 activity and cell invasion.
Bianchi-Smiraglia A, Wolff DW, Marston DJ, Deng Z, Han Z, Moparthy S, Wombacher RM, Mussell AL, Shen S, Chen J, Yun DH, O'Brien Cox A, Furdui CM, Hurley E, Feltri ML, Qu J, Hollis T, Kengne JBN, Fongang B, Sousa RJ, Kandel ME, Kandel ES, Hahn KM, Nikiforov MA
Nature communications 2021 Oct 19;12(1):6091
Nature communications 2021 Oct 19;12(1):6091
Overexpression of DTL enhances cell motility and promotes tumor metastasis in cervical adenocarcinoma by inducing RAC1-JNK-FOXO1 axis.
Liu S, Gu L, Wu N, Song J, Yan J, Yang S, Feng Y, Wang Z, Wang L, Zhang Y, Jin Y
Cell death & disease 2021 Oct 11;12(10):929
Cell death & disease 2021 Oct 11;12(10):929
33-kDa ANXA3 isoform contributes to hepatocarcinogenesis via modulating ERK, PI3K/Akt-HIF and intrinsic apoptosis pathways.
Guo C, Li N, Dong C, Wang L, Li Z, Liu Q, Ma Q, Greenaway FT, Tian Y, Hao L, Liu S, Sun MZ
Journal of advanced research 2021 May;30:85-102
Journal of advanced research 2021 May;30:85-102
Salvianolic acid A prevented cerebrovascular endothelial injury caused by acute ischemic stroke through inhibiting the Src signaling pathway.
Liu CD, Liu NN, Zhang S, Ma GD, Yang HG, Kong LL, Du GH
Acta pharmacologica Sinica 2021 Mar;42(3):370-381
Acta pharmacologica Sinica 2021 Mar;42(3):370-381
Three-dimensional cell-culture platform based on hydrogel with tunable microenvironmental properties to improve insulin-secreting function of MIN6 cells.
Zhang M, Yan S, Xu X, Yu T, Guo Z, Ma M, Zhang Y, Gu Z, Feng Y, Du C, Wan M, Hu K, Han X, Gu N
Biomaterials 2021 Mar;270:120687
Biomaterials 2021 Mar;270:120687
Loss of QKI in macrophage aggravates inflammatory bowel disease through amplified ROS signaling and microbiota disproportion.
Wang W, Zhai D, Bai Y, Xue K, Deng L, Ma L, Du T, Ye Z, Qu D, Xiang A, Chen G, Zhao Y, Wang L, Lu Z
Cell death discovery 2021 Mar 23;7(1):58
Cell death discovery 2021 Mar 23;7(1):58
Tumour-derived exosomal lncRNA-SOX2OT promotes bone metastasis of non-small cell lung cancer by targeting the miRNA-194-5p/RAC1 signalling axis in osteoclasts.
Ni J, Zhang X, Li J, Zheng Z, Zhang J, Zhao W, Liu L
Cell death & disease 2021 Jul 2;12(7):662
Cell death & disease 2021 Jul 2;12(7):662
Long noncoding RNA EPB41L4A-AS1 functions as an oncogene by regulating the Rho/ROCK pathway in colorectal cancer.
Bin J, Nie S, Tang Z, Kang A, Fu Z, Hu Y, Liao Q, Xiong W, Zhou Y, Tang Y, Jiang J
Journal of cellular physiology 2021 Jan;236(1):523-535
Journal of cellular physiology 2021 Jan;236(1):523-535
LIM domain-containing 2 (LIMD2) promotes the progress of ovarian cancer via the focal adhesion signaling pathway.
Chen L, Qian J, You Q, Ma J
Bioengineered 2021 Dec;12(2):10089-10100
Bioengineered 2021 Dec;12(2):10089-10100
6-Thioguanine Inhibits Herpes Simplex Virus 1 Infection of Eyes.
Chen D, Liu Y, Zhang F, You Q, Ma W, Wu J, Wu Z
Microbiology spectrum 2021 Dec 22;9(3):e0064621
Microbiology spectrum 2021 Dec 22;9(3):e0064621
DOCK7 protects against replication stress by promoting RPA stability on chromatin.
Gao M, Guo G, Huang J, Hou X, Ham H, Kim W, Zhao F, Tu X, Zhou Q, Zhang C, Zhu Q, Liu J, Yan Y, Xu Z, Yin P, Luo K, Weroha J, Deng M, Billadeau DD, Lou Z
Nucleic acids research 2021 Apr 6;49(6):3322-3337
Nucleic acids research 2021 Apr 6;49(6):3322-3337
Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis.
Li R, Xiao J, Tang S, Lin X, Xu H, Han B, Yang M, Liu F
Molecular medicine reports 2020 Sep;22(3):2545-2550
Molecular medicine reports 2020 Sep;22(3):2545-2550
RhoG/Rac1 signaling pathway involved in migration and invasion of salivary adenoid cystic carcinoma cells.
Xu ZD, Hao T, Gan YH
Oral diseases 2020 Mar;26(2):302-312
Oral diseases 2020 Mar;26(2):302-312
Modulation of the Pol II CTD Phosphorylation Code by Rac1 and Cdc42 Small GTPases in Cultured Human Cancer Cells and Its Implication for Developing a Synthetic-Lethal Cancer Therapy.
Zhang B, Zhong X, Sauane M, Zhao Y, Zheng ZL
Cells 2020 Mar 4;9(3)
Cells 2020 Mar 4;9(3)
Oxidation of Reduced Graphene Oxide via Cellular Redox Signaling Modulates Actin-Mediated Neurotransmission.
Kang Y, Liu J, Yin S, Jiang Y, Feng X, Wu J, Zhang Y, Chen A, Zhang Y, Shao L
ACS nano 2020 Mar 24;14(3):3059-3074
ACS nano 2020 Mar 24;14(3):3059-3074
RhoA/ROCK Pathway Activation is Regulated by AT1 Receptor and Participates in Smooth Muscle Migration and Dedifferentiation via Promoting Actin Cytoskeleton Polymerization.
Qi Y, Liang X, Dai F, Guan H, Sun J, Yao W
International journal of molecular sciences 2020 Jul 29;21(15)
International journal of molecular sciences 2020 Jul 29;21(15)
Plastin 1 drives metastasis of colorectal cancer through the IQGAP1/Rac1/ERK pathway.
Zhang T, Wang Z, Liu Y, Huo Y, Liu H, Xu C, Mao R, Zhu Y, Liu L, Wei D, Liu G, Pan B, Tang Y, Zhou Z, Yang C, Guo Y
Cancer science 2020 Aug;111(8):2861-2871
Cancer science 2020 Aug;111(8):2861-2871
TNFAIP8 promotes AML chemoresistance by activating ERK signaling pathway through interaction with Rac1.
Pang Y, Zhao Y, Wang Y, Wang X, Wang R, Liu N, Li P, Ji M, Ye J, Sun T, Li J, Ma D, Lu F, Ji C
Journal of experimental & clinical cancer research : CR 2020 Aug 14;39(1):158
Journal of experimental & clinical cancer research : CR 2020 Aug 14;39(1):158
Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate.
Li M, Min W, Wang J, Wang L, Li Y, Zhou N, Yang Z, Qian Q
Experimental and therapeutic medicine 2020 Apr;19(4):2861-2870
Experimental and therapeutic medicine 2020 Apr;19(4):2861-2870
YAP promotes multi-drug resistance and inhibits autophagy-related cell death in hepatocellular carcinoma via the RAC1-ROS-mTOR pathway.
Zhou Y, Wang Y, Zhou W, Chen T, Wu Q, Chutturghoon VK, Lin B, Geng L, Yang Z, Zhou L, Zheng S
Cancer cell international 2019;19:179
Cancer cell international 2019;19:179
Proteomics Analysis Identifies IRSp53 and Fascin as Critical for PRV Egress and Direct Cell-Cell Transmission.
Yu FL, Miao H, Xia J, Jia F, Wang H, Xu F, Guo L
Proteomics 2019 Dec;19(23):e1900009
Proteomics 2019 Dec;19(23):e1900009
CSTF2-Induced Shortening of the RAC1 3'UTR Promotes the Pathogenesis of Urothelial Carcinoma of the Bladder.
Chen X, Zhang JX, Luo JH, Wu S, Yuan GJ, Ma NF, Feng Y, Cai MY, Chen RX, Lu J, Jiang LJ, Chen JW, Jin XH, Liu HL, Chen W, Guan XY, Kang TB, Zhou FJ, Xie D
Cancer research 2018 Oct 15;78(20):5848-5862
Cancer research 2018 Oct 15;78(20):5848-5862
Annexin A5 regulates hepatocarcinoma malignancy via CRKI/II-DOCK180-RAC1 integrin and MEK-ERK pathways.
Sun X, Liu S, Wang J, Wei B, Guo C, Chen C, Sun MZ
Cell death & disease 2018 May 25;9(6):637
Cell death & disease 2018 May 25;9(6):637
PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF‑R.
Zhao Q, Liu Z, Huang B, Yuan Y, Liu X, Zhang H, Qiu F, Zhang Y, Li Y, Miao H, Dong H, Zhang Z
International journal of molecular medicine 2018 Jun;41(6):3243-3252
International journal of molecular medicine 2018 Jun;41(6):3243-3252
Silencing Ras-Related C3 Botulinum Toxin Substrate 1 Inhibits Growth and Migration of Hypopharyngeal Squamous Cell Carcinoma via the P38 Mitogen-Activated Protein Kinase Signaling Pathway.
Cheng H, Wang W, Wang G, Wang A, Du L, Lou W
Medical science monitor : international medical journal of experimental and clinical research 2018 Feb 7;24:768-781
Medical science monitor : international medical journal of experimental and clinical research 2018 Feb 7;24:768-781
Combination antitumor immunotherapy with VEGF and PIGF siRNA via systemic delivery of multi-functionalized nanoparticles to tumor-associated macrophages and breast cancer cells.
Song Y, Tang C, Yin C
Biomaterials 2018 Dec;185:117-132
Biomaterials 2018 Dec;185:117-132
Graphene Oxide Induced Perturbation to Plasma Membrane and Cytoskeletal Meshwork Sensitize Cancer Cells to Chemotherapeutic Agents.
Zhu J, Xu M, Gao M, Zhang Z, Xu Y, Xia T, Liu S
ACS nano 2017 Mar 28;11(3):2637-2651
ACS nano 2017 Mar 28;11(3):2637-2651
Nicotine facilitates VSMC dysfunction through a miR-200b/RhoGDIA/cytoskeleton module.
Liang D, Wang Z, Yan Z, Hou S, Xu W, Wang L, Shang M, Qiao Z
Scientific reports 2017 Mar 2;7:43798
Scientific reports 2017 Mar 2;7:43798
Cathelicidin-WA Improves Intestinal Epithelial Barrier Function and Enhances Host Defense against Enterohemorrhagic Escherichia coli O157:H7 Infection.
Yi H, Hu W, Chen S, Lu Z, Wang Y
Journal of immunology (Baltimore, Md. : 1950) 2017 Feb 15;198(4):1696-1705
Journal of immunology (Baltimore, Md. : 1950) 2017 Feb 15;198(4):1696-1705
A taspine derivative supresses Caco-2 cell growth by competitively targeting EphrinB2 and regulating its pathway.
Dai B, Wang W, Ma Y, Liu R, Zhang Y
Oncology reports 2016 Sep;36(3):1526-34
Oncology reports 2016 Sep;36(3):1526-34
Dihydroartemisinin suppresses pancreatic cancer cells via a microRNA-mRNA regulatory network.
Li Y, Wang Y, Kong R, Xue D, Pan S, Chen H, Sun B
Oncotarget 2016 Sep 20;7(38):62460-62473
Oncotarget 2016 Sep 20;7(38):62460-62473
Metastasis suppressor 1 regulates neurite outgrowth in primary neuron cultures.
Yu J, Lin S, Wang M, Liang L, Zou Z, Zhou X, Wang M, Chen P, Wang Y
Neuroscience 2016 Oct 1;333:123-31
Neuroscience 2016 Oct 1;333:123-31
Upregulated TRIO expression correlates with a malignant phenotype in human hepatocellular carcinoma.
Wang B, Fang J, Qu L, Cao Z, Zhou J, Deng B
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Sep;36(9):6901-8
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Sep;36(9):6901-8
NADPH oxidase-derived production of reactive oxygen species is involved in learning and memory impairments in 16-month-old female rats.
Kan H, Hu W, Wang Y, Wu W, Yin Y, Liang Y, Wang C, Huang D, Li W
Molecular medicine reports 2015 Sep;12(3):4546-4553
Molecular medicine reports 2015 Sep;12(3):4546-4553
Sanguinarine inhibits Rac1b-rendered cell survival enhancement by promoting apoptosis and blocking proliferation.
Ying L, Li G, Wei SS, Wang H, An P, Wang X, Guo K, Luo XJ, Gao JM, Zhou Q, Li W, Yu Y, Li YG, Duan JL, Wang YP
Acta pharmacologica Sinica 2015 Feb;36(2):229-40
Acta pharmacologica Sinica 2015 Feb;36(2):229-40
Screening key microRNAs for castration-resistant prostate cancer based on miRNA/mRNA functional synergistic network.
Zhu J, Wang S, Zhang W, Qiu J, Shan Y, Yang D, Shen B
Oncotarget 2015 Dec 22;6(41):43819-30
Oncotarget 2015 Dec 22;6(41):43819-30
Baculovirus induces host cell aggregation via a Rho/Rok-dependent mechanism.
Deng Z, Huang Z, Yuan M, Yang K, Pang Y
The Journal of general virology 2014 Oct;95(Pt 10):2310-2320
The Journal of general virology 2014 Oct;95(Pt 10):2310-2320
Protective effects of ginsenoside Rg1 on chronic restraint stress induced learning and memory impairments in male mice.
Wang Y, Kan H, Yin Y, Wu W, Hu W, Wang M, Li W, Li W
Pharmacology, biochemistry, and behavior 2014 May;120:73-81
Pharmacology, biochemistry, and behavior 2014 May;120:73-81
Elevated Orai1 expression mediates tumor-promoting intracellular Ca2+ oscillations in human esophageal squamous cell carcinoma.
Zhu H, Zhang H, Jin F, Fang M, Huang M, Yang CS, Chen T, Fu L, Pan Z
Oncotarget 2014 Jun 15;5(11):3455-71
Oncotarget 2014 Jun 15;5(11):3455-71
RACK1 promotes the proliferation, migration and invasion capacity of mouse hepatocellular carcinoma cell line in vitro probably by PI3K/Rac1 signaling pathway.
Wu J, Meng J, Du Y, Huang Y, Jin Y, Zhang J, Wang B, Zhang Y, Sun M, Tang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2013 May;67(4):313-9
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2013 May;67(4):313-9
The phosphodiesterase-5 inhibitor vardenafil reduces oxidative stress while reversing pulmonary arterial hypertension.
Fan YF, Zhang R, Jiang X, Wen L, Wu DC, Liu D, Yuan P, Wang YL, Jing ZC
Cardiovascular research 2013 Aug 1;99(3):395-403
Cardiovascular research 2013 Aug 1;99(3):395-403
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Rac1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human Rac1. This antibody recognizes human antigen. The Rac1 antibody has been validated for the following applications: ELISA, WB analysis.
