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- References [15]
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- Product number
- 66122-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- Rac1 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated RAC1 antibody (Cat. #66122-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 4A4B11
- Vial size
- 20ul, 150ul
Submitted references Ras-Related C3 Botulinum Toxin Substrate 1 Combining With the Mixed Lineage Kinase 3- Mitogen-Activated Protein Kinase 7- c-Jun N-Terminal Kinase Signaling Module Accelerates Diabetic Nephropathy.
Regulation of local GTP availability controls RAC1 activity and cell invasion.
Smoking-associated upregulation of CBX3 suppresses ARHGAP24 expression to activate Rac1 signaling and promote tumor progression in lung adenocarcinoma.
Scoparone alleviates Ang II-induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress.
TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection.
The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis-activation and the consequent initiation of Rho GTPase-mediated signaling.
MicroRNA-200b/c-3p regulate epithelial plasticity and inhibit cutaneous wound healing by modulating TGF-β-mediated RAC1 signaling.
Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ.
Kidney targeted delivery of asiatic acid using a FITC labeled renal tubular-targeting peptide modified PLGA-PEG system.
Transplanting Rac1-silenced bone marrow mesenchymal stem cells promote neurological function recovery in TBI mice.
4-Octyl itaconate protects against renal fibrosis via inhibiting TGF-β/Smad pathway, autophagy and reducing generation of reactive oxygen species.
DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53.
Inhibition of KLF5-Myo9b-RhoA Pathway-Mediated Podosome Formation in Macrophages Ameliorates Abdominal Aortic Aneurysm.
The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocarcinoma cells.
Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets.
Ying C, Dai J, Fan G, Zhou Z, Gan T, Zhang Y, Song Y, Zhou X
Frontiers in physiology 2021;12:679166
Frontiers in physiology 2021;12:679166
Regulation of local GTP availability controls RAC1 activity and cell invasion.
Bianchi-Smiraglia A, Wolff DW, Marston DJ, Deng Z, Han Z, Moparthy S, Wombacher RM, Mussell AL, Shen S, Chen J, Yun DH, O'Brien Cox A, Furdui CM, Hurley E, Feltri ML, Qu J, Hollis T, Kengne JBN, Fongang B, Sousa RJ, Kandel ME, Kandel ES, Hahn KM, Nikiforov MA
Nature communications 2021 Oct 19;12(1):6091
Nature communications 2021 Oct 19;12(1):6091
Smoking-associated upregulation of CBX3 suppresses ARHGAP24 expression to activate Rac1 signaling and promote tumor progression in lung adenocarcinoma.
Jin X, Zhang B, Zhang H, Yu H
Oncogene 2021 Nov 16;
Oncogene 2021 Nov 16;
Scoparone alleviates Ang II-induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress.
Lyu L, Chen J, Wang W, Yan T, Lin J, Gao H, Li H, Lv R, Xu F, Fang L, Chen Y
Journal of cellular and molecular medicine 2021 Mar;25(6):3136-3148
Journal of cellular and molecular medicine 2021 Mar;25(6):3136-3148
TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection.
Geng J, Shi Y, Zhang J, Yang B, Wang P, Yuan W, Zhao H, Li J, Qin F, Hong L, Xie C, Deng X, Sun Y, Wu C, Chen L, Zhou D
Nature communications 2021 Jun 10;12(1):3519
Nature communications 2021 Jun 10;12(1):3519
The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis-activation and the consequent initiation of Rho GTPase-mediated signaling.
Hu X, Xiang L, He D, Zhu R, Fang J, Wang Z, Cao K
Clinical science (London, England : 1979) 2021 Feb 12;135(3):555-574
Clinical science (London, England : 1979) 2021 Feb 12;135(3):555-574
MicroRNA-200b/c-3p regulate epithelial plasticity and inhibit cutaneous wound healing by modulating TGF-β-mediated RAC1 signaling.
Tang H, Wang X, Zhang M, Yan Y, Huang S, Ji J, Xu J, Zhang Y, Cai Y, Yang B, Lan W, Huang M, Zhang L
Cell death & disease 2020 Oct 29;11(10):931
Cell death & disease 2020 Oct 29;11(10):931
Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ.
Zhang ZH, He JQ, Zhao YY, Chen HC, Tan NH
Acta pharmacologica Sinica 2020 Mar;41(3):373-382
Acta pharmacologica Sinica 2020 Mar;41(3):373-382
Kidney targeted delivery of asiatic acid using a FITC labeled renal tubular-targeting peptide modified PLGA-PEG system.
He J, Chen H, Zhou W, Chen M, Yao Y, Zhang Z, Tan N
International journal of pharmaceutics 2020 Jun 30;584:119455
International journal of pharmaceutics 2020 Jun 30;584:119455
Transplanting Rac1-silenced bone marrow mesenchymal stem cells promote neurological function recovery in TBI mice.
Huang D, Siaw-Debrah F, Wang H, Ye S, Wang K, Wu K, Zhang Y, Wang H, Yao C, Chen J, Yan L, Zhang CL, Zhuge Q, Yang J
Aging 2020 Dec 19;13(2):2822-2850
Aging 2020 Dec 19;13(2):2822-2850
4-Octyl itaconate protects against renal fibrosis via inhibiting TGF-β/Smad pathway, autophagy and reducing generation of reactive oxygen species.
Tian F, Wang Z, He J, Zhang Z, Tan N
European journal of pharmacology 2020 Apr 15;873:172989
European journal of pharmacology 2020 Apr 15;873:172989
DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53.
Wudu M, Ren H, Hui L, Jiang J, Zhang S, Xu Y, Wang Q, Su H, Jiang X, Dao R, Qiu X
Journal of experimental & clinical cancer research : CR 2019 Feb 12;38(1):72
Journal of experimental & clinical cancer research : CR 2019 Feb 12;38(1):72
Inhibition of KLF5-Myo9b-RhoA Pathway-Mediated Podosome Formation in Macrophages Ameliorates Abdominal Aortic Aneurysm.
Ma D, Zheng B, Suzuki T, Zhang R, Jiang C, Bai D, Yin W, Yang Z, Zhang X, Hou L, Zhan H, Wen JK
Circulation research 2017 Mar 3;120(5):799-815
Circulation research 2017 Mar 3;120(5):799-815
The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocarcinoma cells.
Li J, Zhang S, Hu Q, Zhang K, Jin J, Zheng X, Yin Z, Wang X
Scientific reports 2016 May 27;6:26971
Scientific reports 2016 May 27;6:26971
Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets.
Zhou T, Zhang B, Wei P, Du Y, Zhou H, Yu M, Yan L, Zhang W, Nie G, Chen C, Tu Y, Wei T
Biomaterials 2014 Dec;35(37):9833-9843
Biomaterials 2014 Dec;35(37):9833-9843
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Rac1 antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human Rac1. This antibody recognizes human,mouse antigen. The Rac1 antibody has been validated for the following applications: ELISA, WB analysis.
