690902

antibody from BioLegend

Targeting: NOS2 HEP-NOS, iNOS, NOS, NOS2A

Immunocytochemistry

Antibody data

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Validation data

Product number: 690902 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#690902, RRID:AB_2629826
Product name: Purified anti-NOS2
Antibody type: Monoclonal
Description: Nitric Oxide Synthase 2 (NOS2), also known as inducible NOS (iNOS), contains an N-terminal oxygenase domain and a C-terminal reductase domain, and functions to catalyze the formation of nitric oxide (NO) from L-arginine. NO is a reactive free radical which acts as a biologic messenger with diverse functions throughout the body, such as neurotransmission, antimicrobial, and antitumor activity. NOS2 is involved in inflammatory responses and enhances the synthesis of PGE2 and proinflammatory cytokines such as IL-6 and IL-8. The NOS2 gene is highly expressed in liver and is inducible by a combination of bacterial endotoxins and certain cytokines, including IL-1, IFNγ and TNFα. NOS2 also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such as COX2.
Reactivity: Human, Mouse
Host: Mouse
Conjugate: Unconjugated
Antibody clone number: 5C1B52
Vial size: 100 µg
Concentration: 0.5 mg/ml
Storage: 2°C-8°C
Handling: Ambient RT

NOS2 protein structure - 690902 shown in red.