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- Antigen structure
- References [17]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- 66161-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- BMI1 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated BMI1 antibody (Cat. #66161-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, monkey and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Simian
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 2E10A11
- Vial size
- 20ul, 150ul
Submitted references CD80-Mediated T-Cell Suppression by Cancer Stem-like Cells in Head and Neck Squamous Cell Carcinoma.
Bmi-1 overexpression mitigates vitamin D deficiency-induced pulmonary fibrosis via TIME pathway.
Chk2 Modulates Bmi1-Deficiency-Induced Renal Aging and Fibrosis via Oxidative Stress, DNA Damage, and p53/TGFβ1-Induced Epithelial-Mesenchymal Transition.
Neuron stress-related genes serve as new biomarkers in hypothalamic tissue following high fat diet.
Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells.
Bmi-1 Epigenetically Orchestrates Osteogenic and Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells to Delay Bone Aging.
Hairy gene homolog increases nasopharyngeal carcinoma cell stemness by upregulating Bmi-1.
Bmi-1 Overexpression Improves Sarcopenia Induced by 1,25(OH)(2) D(3) Deficiency and Downregulates GATA4-Dependent Rela Transcription.
Apo- and holo-transferrin differentially interact with hephaestin and ferroportin in a novel mechanism of cellular iron release regulation.
Chronic Alcohol Reduces Bone Mass Through Inhibiting Proliferation and Promoting Aging of Endothelial Cells in Type-H Vessels.
MCM2 promotes the stemness and sorafenib resistance of hepatocellular carcinoma cells via hippo signaling.
Bmi-1-RING1B prevents GATA4-dependent senescence-associated pathological cardiac hypertrophy by promoting autophagic degradation of GATA4.
EPS8 supports pancreatic cancer growth by inhibiting BMI1 mediated proteasomal degradation of ALDH7A1.
Identification of a mesenchymal-related signature associated with clinical prognosis in glioma.
Ubiquitin-specific protease 22 acts as an oncoprotein to maintain glioma malignancy through deubiquitinating B cell-specific Moloney murine leukemia virus integration site 1 for stabilization.
Evaluating the Mechanism and Therapeutic Potential of PTC-028, a Novel Inhibitor of BMI-1 Function in Ovarian Cancer.
Inhibition of BMI1 induces autophagy-mediated necroptosis.
Xiao M, Qiu L, Gao Q, Li R, Wang J, Feng Y, Li X, Ge X
Cells 2026 Jan 30;15(3)
Cells 2026 Jan 30;15(3)
Bmi-1 overexpression mitigates vitamin D deficiency-induced pulmonary fibrosis via TIME pathway.
Zhang J, Huang M, Zhou J, Chen H, Wang Z, Jin J, Shu L, Miao D
Cellular signalling 2025 Dec;136:112180
Cellular signalling 2025 Dec;136:112180
Chk2 Modulates Bmi1-Deficiency-Induced Renal Aging and Fibrosis via Oxidative Stress, DNA Damage, and p53/TGFβ1-Induced Epithelial-Mesenchymal Transition.
Lu J, Sun W, Liu B, Zhang J, Wang R, Goltzman D, Miao D
International journal of biological sciences 2024;20(6):2008-2026
International journal of biological sciences 2024;20(6):2008-2026
Neuron stress-related genes serve as new biomarkers in hypothalamic tissue following high fat diet.
Liang C, Lu H, Wang X, Su J, Qi F, Shang Y, Li Y, Zhang D, Duan C
Frontiers in endocrinology 2024;15:1443880
Frontiers in endocrinology 2024;15:1443880
Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells.
Dai W, Liu Z, Yan M, Nian X, Hong F, Zhou Z, Wang C, Fu X, Li X, Jiang M, Zhu Y, Huang Q, Lu X, Hou L, Yan N, Wang Q, Hu J, Mo W, Zhang X, Zhang L
Developmental cell 2024 Feb 26;59(4):482-495.e6
Developmental cell 2024 Feb 26;59(4):482-495.e6
Bmi-1 Epigenetically Orchestrates Osteogenic and Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells to Delay Bone Aging.
Zhao J, Chen A, Wang R, Qiu D, Chen H, Li J, Zhang J, Wang T, Wang Y, Lin Y, Zhou J, Du Y, Yuan H, Zhang Y, Miao D, Wang Y, Jin J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(46):e2404518
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(46):e2404518
Hairy gene homolog increases nasopharyngeal carcinoma cell stemness by upregulating Bmi-1.
Lei Y, Shen HF, Li QW, Yang S, Xie HT, Li XF, Chen ML, Xia JW, Wang SC, Dai GQ, Zhou Y, Li YC, Huang SH, He DH, Zhou ZH, Cong JG, Lin XL, Lin TY, Wu AB, Xiao D, Xiao SJ, Zhang XK, Jia JS
Aging 2023 May 22;15(10):4391-4410
Aging 2023 May 22;15(10):4391-4410
Bmi-1 Overexpression Improves Sarcopenia Induced by 1,25(OH)(2) D(3) Deficiency and Downregulates GATA4-Dependent Rela Transcription.
Wang Q, Zhao J, Chen H, Zhou J, Chen A, Zhang J, Wang Y, Mao Z, Wang J, Qiu X, Chen Y, Wang R, Zhang Y, Miao D, Jin J
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2023 Mar;38(3):427-442
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2023 Mar;38(3):427-442
Apo- and holo-transferrin differentially interact with hephaestin and ferroportin in a novel mechanism of cellular iron release regulation.
Baringer SL, Palsa K, Spiegelman VS, Simpson IA, Connor JR
Journal of biomedical science 2023 Jun 6;30(1):36
Journal of biomedical science 2023 Jun 6;30(1):36
Chronic Alcohol Reduces Bone Mass Through Inhibiting Proliferation and Promoting Aging of Endothelial Cells in Type-H Vessels.
Chen A, Li X, Zhao J, Zhou J, Xie C, Chen H, Wang Q, Wang R, Miao D, Li J, Jin J
Stem cells and development 2022 Sep;31(17-18):541-554
Stem cells and development 2022 Sep;31(17-18):541-554
MCM2 promotes the stemness and sorafenib resistance of hepatocellular carcinoma cells via hippo signaling.
Zhou X, Luo J, Xie H, Wei Z, Li T, Liu J, Liao X, Zhu G, Peng T
Cell death discovery 2022 Oct 15;8(1):418
Cell death discovery 2022 Oct 15;8(1):418
Bmi-1-RING1B prevents GATA4-dependent senescence-associated pathological cardiac hypertrophy by promoting autophagic degradation of GATA4.
Chen H, Zhou J, Chen H, Liang J, Xie C, Gu X, Wang R, Mao Z, Zhang Y, Li Q, Zuo G, Miao D, Jin J
Clinical and translational medicine 2022 Apr;12(4):e574
Clinical and translational medicine 2022 Apr;12(4):e574
EPS8 supports pancreatic cancer growth by inhibiting BMI1 mediated proteasomal degradation of ALDH7A1.
Tan M, Meng J, Sun X, Fu X, Wang R
Experimental cell research 2021 Oct 1;407(1):112782
Experimental cell research 2021 Oct 1;407(1):112782
Identification of a mesenchymal-related signature associated with clinical prognosis in glioma.
Zhang Z, Chen J, Huo X, Zong G, Huang K, Cheng M, Sun L, Yue X, Bian E, Zhao B
Aging 2021 Apr 19;13(9):12431-12455
Aging 2021 Apr 19;13(9):12431-12455
Ubiquitin-specific protease 22 acts as an oncoprotein to maintain glioma malignancy through deubiquitinating B cell-specific Moloney murine leukemia virus integration site 1 for stabilization.
Qiu GZ, Mao XY, Ma Y, Gao XC, Wang Z, Jin MZ, Sun W, Zou YX, Lin J, Fu HL, Jin WL
Cancer science 2018 Jul;109(7):2199-2210
Cancer science 2018 Jul;109(7):2199-2210
Evaluating the Mechanism and Therapeutic Potential of PTC-028, a Novel Inhibitor of BMI-1 Function in Ovarian Cancer.
Dey A, Xiong X, Crim A, Dwivedi SKD, Mustafi SB, Mukherjee P, Cao L, Sydorenko N, Baiazitov R, Moon YC, Dumble M, Davis T, Bhattacharya R
Molecular cancer therapeutics 2018 Jan;17(1):39-49
Molecular cancer therapeutics 2018 Jan;17(1):39-49
Inhibition of BMI1 induces autophagy-mediated necroptosis.
Dey A, Mustafi SB, Saha S, Kumar Dhar Dwivedi S, Mukherjee P, Bhattacharya R
Autophagy 2016;12(4):659-70
Autophagy 2016;12(4):659-70
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- U-937 cells were subjected to SDS PAGE followed by western blot with 66161-1-Ig( BMI1 Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BMI1 antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human BMI1. This antibody recognizes human, mouse antigen. The BMI1 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
