10430-1-AP

antibody from Proteintech Group

Targeting: CDK5 PSSALRE

Provider product page for 10430-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [24]
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Validations
Western blot [1]

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Product number: 10430-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10430-1-AP, RRID:AB_2078859
Product name: CDK5 antibody
Antibody type: Polyclonal
Description: KD/KO validated CDK5 antibody (Cat. #10430-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CDK5 protein structure - 10430-1-AP shown in red.

Submitted references Pseudohypoxia induced by iron chelators preserves working memory performance in aged mice.

Ohara T, Iwasaki Y, Kasai T, Yamashita T, Komaki S, Hamada Y, Fujisawa M, Matsukawa A
Scientific reports 2026 Mar 2;16(1)

Mechanistic study on Kai Xin San's regulation of DARPP-32 phosphorylation in anti-depressant effects based on multi-omics.

Shan M, Xu L, Dong J, Zhang X, Fang X, Luo H
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120746

CDK5 regulates PPARγ/NF-κB signaling to exacerbate obesity-related osteoarthritis via modulating macrophage polarization and chondrocyte apoptosis.

Li Y, Li H, Chen X, Li X, Su J, Yang S, Xiao W, Deng Z
Cellular & molecular biology letters 2025 Nov 13;30(1):135

Inhibition of CDK5 signaling mediated inflammation in macrophages promotes cutaneous wound healing.

Wang J, Ji L, Gao Y, Sun J, Zhou X, Ding Y, Zhou Z, Guo X, Liu C, Wang Y, Zhang Q, Lv Z, Ma D
Scientific reports 2025 May 27;15(1):18509

FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation.

Xiao D, Ran H, Chen L, Li Y, Cai Y, Zhang S, Qi Q, Wu H, Zhang C, Cao S, Mi L, Huang H, Qi J, Han Q, Tu H, Li H, Zhou T, Li F, Li A, Man J
Science China. Life sciences 2025 Mar;68(3):673-688

CDK5-triggered G6PD phosphorylation at threonine 91 facilitating redox homeostasis reveals a vulnerability in breast cancer.

Bei Y, Wang S, Wang R, Ahmad O, Jia M, Yao P, Ji J, Shen P
Acta pharmaceutica Sinica. B 2025 Mar;15(3):1608-1625

IMPDH2 dephosphorylation under FGFR signaling promotes S-phase progression and tumor growth.

Zhou B, Zhao Q, Hou G, He J, Sha N, Zheng K, Peng H, Wang W, Zhou Y, Chen T, Jiang Y
Cell reports 2025 Jan 28;44(1):115116

Ginsenoside CK modulates glucose metabolism via PPARγ to ameliorate SCOP-induced cognitive dysfunction.

Li N, Fang X, Li H, Liu J, Chen N, Zhao X, Yang Q, Chen X
Metabolic brain disease 2025 Apr 3;40(4):168

Proteogenomic characterization of non-functional pancreatic neuroendocrine tumors unravels clinically relevant subgroups.

Ji S, Cao L, Gao J, Du Y, Ye Z, Lou X, Liu F, Zhang Y, Xu J, Shi X, Wang H, Li P, Li Y, Chen H, Yang Z, Gao S, Zhang W, Huang D, Ni S, Wei M, Wang F, Wang Y, Ding T, Jing D, Fan G, Gong Z, Lu R, Qin Y, Chen J, Xu X, Wang P, Zhang B, Ding L, Robles AI, Rodriguez H, Chang DK, Hruban RH, Gao D, Gao D, Jin G, Zhou H, Wu J, Yu X
Cancer cell 2025 Apr 14;43(4):776-796.e14

Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers.

Hnath B, Dokholyan NV
bioRxiv : the preprint server for biology 2025 Apr 10;

EphrinB2-mediated CDK5/ISL1 pathway enhances cardiac lymphangiogenesis and alleviates ischemic injury by resolving post-MI inflammation.

Bai Y, Chen L, Guo F, Zhang J, Hu J, Tao X, Lu Q, Li W, Chen X, Gong T, Qiu N, Jin Y, Yang L, Lei Y, Ruan C, Jing Q, Cooke JP, Wang S, Zou Y, Ge J
Signal transduction and targeted therapy 2024 Nov 18;9(1):326

FBXO22 is a potential therapeutic target for recurrent chondrosarcoma.

Xin B, Chen H, Zhu Z, Guan Q, Bai G, Yang C, Zou W, Gao X, Li L, Liu T
Journal of bone oncology 2024 Jun;46:100605

Electroacupuncture ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment through suppressing oxidative stress and neuroinflammation in rats.

Tong T, Hao C, Shen J, Liu S, Yan S, Aslam MS, Chen Y, Chen W, Li J, Li Y, Zeng J, Li M, You Z, Gulizhaerkezi T, Wei S, Zhu A, Meng X
Brain research bulletin 2024 Jan;206:110838

The γ-Adducin 1-357 fragment promotes tau pathology.

Yu H, Xiong M, Liu C, Xia D, Meng L, Zhang Z
Frontiers in aging neuroscience 2023;15:1241750

Rac is required for the survival of cortical neurons.

Katayama KI, Zheng Y, Inoue N
Experimental neurology 2023 Mar;361:114316

Highly effective identification of drug targets at the proteome level by pH-dependent protein precipitation.

Zhang X, Wang K, Wu S, Ruan C, Li K, Wang Y, Zhu H, Liu X, Liu Z, Li G, Hu L, Ye M
Chemical science 2022 Nov 2;13(42):12403-12418

The LPA-CDK5-tau pathway mediates neuronal injury in an in vitro model of ischemia-reperfusion insult.

Wang Y, Zhang J, Huang L, Mo Y, Wang C, Li Y, Zhang Y, Zhang Z
BMC neurology 2022 May 2;22(1):166

Phosphorylation-Induced Ubiquitination and Degradation of PXR through CDK2-TRIM21 Axis.

Qin M, Xin Y, Bian Y, Yang X, Xi T, Xiong J
Cells 2022 Jan 13;11(2)

SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis.

Guo S, Lei X, Chang Y, Zhao J, Wang J, Dong X, Liu Q, Zhang Z, Wang L, Yi D, Ma L, Li Q, Zhang Y, Ding J, Liang C, Li X, Guo F, Wang J, Cen S
Signal transduction and targeted therapy 2022 Dec 27;7(1):400

Hypoxia induces HT-22 neuronal cell death via Orai1/CDK5 pathway-mediated Tau hyperphosphorylation.

Fang B, Zhao Q, Ling W, Zhang Y, Ou M
American journal of translational research 2019;11(12):7591-7603

Ginsenoside compound K ameliorates Alzheimer's disease in HT22 cells by adjusting energy metabolism.

Chen X, Li H, Yang Q, Lan X, Wang J, Cao Z, Shi X, Li J, Kan M, Qu X, Li N
Molecular biology reports 2019 Oct;46(5):5323-5332

Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.

Mao Z, Han X, Chen D, Xu Y, Xu L, Yin L, Sun H, Qi Y, Fang L, Liu K, Peng J
British journal of pharmacology 2019 Apr;176(7):919-937

Inhibition of Cdk5 rejuvenates inhibitory circuits and restores experience-dependent plasticity in adult visual cortex.

Li Y, Wang L, Zhang X, Huang M, Li S, Wang X, Chen L, Jiang B, Yang Y
Neuropharmacology 2018 Jan;128:207-220

Nestin protects mouse podocytes against high glucose-induced apoptosis by a Cdk5-dependent mechanism.

Liu W, Zhang Y, Hao J, Liu S, Liu Q, Zhao S, Shi Y, Duan H
Journal of cellular biochemistry 2012 Oct;113(10):3186-96

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The CDK5 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CDK5. This antibody recognizes human, mouse, rat antigen. The CDK5 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 10430-1-AP.pdf

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