66180-1-Ig

antibody from Proteintech Group

Targeting: TFRC CD71, p90, TFR1

Provider product page for 66180-1-Ig

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [51]
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Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 66180-1-Ig - Provider product page
Provider: Proteintech Group
Product name: CD71 antibody
Antibody type: Monoclonal
Description: KD/KO validated CD71 antibody (Cat. #66180-1-Ig) is a mouse monoclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 3C11F11
Vial size: 20ul, 150ul

TFRC protein structure - 66180-1-Ig shown in red.

Submitted references Brain delivery of a neurotrophic peptide derived from secreted amyloid precursor protein APPsα as a therapeutic strategy for Alzheimer's disease.

Rehra L, Erdinger S, Wagner L, Baltissen D, Just J, König L, Mühlberg E, Eisenzapf T, Kilian L, Banicevic M, Bengelsdorff V, Buchholz CJ, Mier W, Uhl P, Korte M, Fricker G, Müller UC
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114374

Ferritin-nanocaged aggregation-induced emission nanoaggregates for integrated sensitive detection and treatment of gastric cancer.

Deng J, Zhang Z, Li K, Zheng Y, Zheng Y
Materials today. Bio 2026 Feb;36:102769

Targeting mitochondrial phosphatase PGAM5 alleviates ferroptosis and acute pancreatitis by upregulating NRF2-mediated FSP1 expression.

Ma S, Qin J, Luan J, Hou G, He J, Gao M
Cell death & disease 2026 Feb 21;17(1)

O-GlcNAc Modification Orchestrates HUWE1-Mediated Ubiquitination of TfR1 to Regulate Ferroptosis and Trophoblast Syncytialization in Preeclampsia.

Zhang H, Li M, Zhang J, Sun Q, Jin X, Liu R, Li X, Chen X, Wang A, Luo Z, Shang Y, Kong Y
Free radical biology & medicine 2026 Apr 8;

Altered Iron Regulation and the Role of Ferritin Heavy Chain in Dermatomyositis Patients.

Li Q, Cheng X, Zhou M, Ji N, Zhu S, Jiang J, Fang Q, Liu M
Journal of inflammation research 2025;18:14697-14707

CAV1 promotes epithelial-to-mesenchymal transition (EMT) and chronic renal allograft interstitial fibrosis by activating the ferroptosis pathway.

Han Q, Ni B, Bao W, Zhang J, Zheng M, Miu J, Wang Z, Yuan J, Tao J, Han Z, Gu M, Ju X, Tan R
Frontiers in immunology 2025;16:1523855

Inhibiting ferroptosis mitigates sheep sperm freezing damage.

Hai E, Li B, Song Y, Zhang J, Zhang J
Frontiers in veterinary science 2025;12:1526474

Protocol for immunostaining of non-adherent cells and cellular structures using centrifugal filter devices.

Miyazawa M, Kawai K, Yamamoto S, Kitagawa D
STAR protocols 2025 Sep 19;6(3):103934

RNA binding protein SERBP1 is indispensable for oocyte development and maturation in mice.

Wang L, OuYang S, Li B, Kong N
Molecular and cellular endocrinology 2025 Sep 1;:112644

Ferredoxin 1-like maintains iron homeostasis and hepatoma cell survival.

Zheng J, Zheng S, Zhou Q, Wu Y, Zhu C, Zheng Y, Li H, Li M, Zhong W, Yan D
Free radical biology & medicine 2025 Oct;238:52-63

TfR1 facilitates influenza virus endocytosis and uncoating by interacting with NA and M1 via extracellular and intracellular domains.

Wang X, Li Y, Ji D, Wang Y, Wang X, Guo K, Wang M, Mu Y, Qin C, Yuan T, Zhang Y, Chen Z, Zhu X, Zhang X, Jiang H, He Q, Zhang C, Xiao S, Zhang L, Zhou D
PLoS pathogens 2025 Oct;21(10):e1013511

Increase of brain Aβ peptides and secretase activity during normal aging in rodent and human.

Godoy-Lugo JA, Thorwald MA, Head E, Gomm AL, Zhang C, Tanzi RE, Finch CE
GeroScience 2025 Oct 14;

Syntaxin-6 restricts SARS-CoV-2 infection by facilitating virus trafficking to autophagosomes.

Sun H, Yang Q, Zhang Y, Cui S, Zhou Z, Zhang P, Jia L, Zhang M, Wang Y, Chen X, Pei R
Journal of virology 2025 May 20;99(5):e0000225

Injectable thermosensitive hydrogel system based on hyaluronic acid and methylcellulose for the synergistic therapy of traumatic spinal cord injury.

Zhao JY, Wang W, Yin Z, Hou LS, Zhang YW, Cai Z, Guan Y, Wang J, Zhang BL
International journal of biological macromolecules 2025 Jun;316(Pt 2):144629

Targeting inhibition of T3JAM reduces brain cell ferroptosis in rat following ischemia/reperfusion via a mechanism involving prevention of TLR4-mediated iron overload.

Li Q, Zhang YY, Peng D, Liu HR, Wu L, Tang TT, Luo XJ
Archives of biochemistry and biophysics 2025 Jan;763:110225

Ferroptosis emerges as the predominant form of regulated cell death in goat sperm cryopreservation.

Hai E, Li B, Song Y, Zhang J, Zhang J
Journal of animal science and biotechnology 2025 Feb 18;16(1):26

AAK1 activation-mediated iron trafficking drives ferroptotic cell death.

Li LC, Ye ZP, Xiao Y, Zhu XY, Li QQ, Guo YQ, Wu HL, Li ZL, Wu LY, Chen YH, Feng GK, Yang D, Liu S, Hu BX, Tang JH, Zhou YF, Li J, Deng R, Zhang HL, Zhu XF
Nature communications 2025 Dec 17;17(1):819

Targeting hypoxia-inducible factor-1 in a hypoxidative stress model protects retinal pigment epithelium cells from cell death and metabolic dysregulation.

Schubert A, Lobo Barbosa da Silva ME, Ambrock T, Terosian O, Malyshkina A, Padberg C, Larafa S, Matschke J, Fandrey J, Henning Y
Cell death discovery 2025 Aug 14;11(1):380

Electroacupuncture improves postoperative cognitive dysfunction by inhibiting ferroptosis via the TFR1-DMT1-FPN pathway.

Chen T, Zhang B, Zhang X, Tang L, Wang C
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2025 Apr;43(2):74-84

Nrf2 alleviates acute ischemic stroke induced ferroptosis via regulating xCT/GPX4 pathway.

Ye Y, Xie X, Bi Y, Liu Q, Qiu L, Zhao H, Wang C, Zhu W, Zeng T
Free radical biology & medicine 2025 Apr;231:153-162

CREG1 attenuates doxorubicin-induced cardiotoxicity by inhibiting the ferroptosis of cardiomyocytes.

Liu D, Cheng X, Wu H, Song H, Bu Y, Wang J, Zhang X, Yan C, Han Y
Redox biology 2024 Sep;75:103293

Effect of ferric citrate on hippocampal iron accumulation and widespread molecular alterations associated with cognitive disorder in an ovariectomized mice model.

Cui L, Zhou H, Hao Y, Yang X, Li Z, Gao Y, Zhang Z, Ren L, Ji L, Sun R, Wang Y, Wang X
CNS neuroscience & therapeutics 2024 Sep;30(9):e70018

A novel UVA-associated circUBE2I mediates ferroptosis in HaCaT cells.

Yi P, Huang Y, Zhao X, Qin Z, Zhu D, Liu L, Zheng Y, Feng J, Long M
Photochemistry and photobiology 2024 Sep-Oct;100(5):1365-1377

Inhibition of Slc39a14/Slc39a8 reduce vascular calcification via alleviating iron overload induced ferroptosis in vascular smooth muscle cells.

Aierken Y, He H, Li R, Lin Z, Xu T, Zhang L, Wu Y, Liu Y
Cardiovascular diabetology 2024 May 29;23(1):186

Water extract of moschus alleviates erastin-induced ferroptosis by regulating the Keap1/Nrf2 pathway in HT22 cells.

Song C, Chu Z, Dai J, Xie D, Qin T, Xie L, Zhai Z, Huang S, Xu Y, Sun T
Journal of ethnopharmacology 2024 May 23;326:117937

Iron promotes ovarian cancer malignancy and advances platinum resistance by enhancing DNA repair via FTH1/FTL/POLQ/RAD51 axis.

Zhang Q, Chen C, Zou X, Wu W, Di Y, Li N, Fu A
Cell death & disease 2024 May 13;15(5):329

Characterization of the proteome of stable and unstable carotid atherosclerotic plaques using data-independent acquisition mass spectrometry.

Lai Z, Wang C, Liu X, Sun H, Guo Z, Shao J, Li K, Chen J, Wang J, Lei X, Shu K, Feng Y, Kong D, Sun W, Liu B
Journal of translational medicine 2024 Mar 7;22(1):247

E3 ubiquitin ligase CHIP interacts with transferrin receptor 1 for degradation and promotes cell proliferation through inhibiting ferroptosis in hepatocellular carcinoma.

Shao M, Qi K, Wang L, Yu X, Zhang Q, Yu L, Wang L, Yang C, Fan L
Cellular signalling 2024 Jun;118:111148

Chemical screen in zebrafish lateral line identified compounds that ameliorate neomycin-induced ototoxicity by inhibiting ferroptosis pathway.

Fan Y, Zhang Y, Qin D, Shu X
Cell & bioscience 2024 Jun 5;14(1):71

BACH1 inhibits senescence, obesity, and short lifespan by ferroptotic FGF21 secretion.

Nishizawa H, Matsumoto M, Yamanaka M, Irikura R, Nakajima K, Tada K, Nakayama Y, Konishi M, Itoh N, Funayama R, Nakayama K, Igarashi K
Cell reports 2024 Jul 23;43(7):114403

Apelin deficiency exacerbates cardiac injury following infarction by accelerating cardiomyocyte ferroptosis.

Zhao Y, Liang X, Li T, Shao Z, Cao Z, Zeng Y, Yan X, Chen Q, Zhou H, Li W, Cheng G, Jiang Y, Li X, Zhang Y, Hu B
Free radical research 2024 Dec;58(12):854-867

The Association of Transferrin Receptor with Prognosis and Biologic Role in Intrahepatic Cholangiocarcinoma.

Toshida K, Itoh S, Iseda N, Izumi T, Bekki Y, Yoshiya S, Toshima T, Iwasaki T, Oda Y, Yoshizumi T
Annals of surgical oncology 2024 Dec;31(13):8627-8637

Sirtuin1 Suppresses Calcium Oxalate Nephropathy via Inhibition of Renal Proximal Tubular Cell Ferroptosis Through PGC-1α-mediated Transcriptional Coactivation.

Duan C, Li B, Liu H, Zhang Y, Yao X, Liu K, Wu X, Mao X, Wu H, Xu Z, Zhong Y, Hu Z, Gong Y, Xu H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(48):e2408945

PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.

Lai W, Yu L, Deng Y
Communications biology 2024 Apr 9;7(1):429

Paraquat-induced ferroptosis suppression via NRF2 expression regulation.

Cai Q, Shen Q, Zhu W, Zhang S, Ke J, Lu Z
Toxicology in vitro : an international journal published in association with BIBRA 2023 Oct;92:105655

The deubiquitinase ZRANB1 is an E3 ubiquitin ligase for SLC7A11 and regulates ferroptotic resistance.

Huang S, Zhang Q, Zhao M, Wang X, Zhang Y, Gan B, Zhang P
The Journal of cell biology 2023 Nov 6;222(11)

Super-enhancer-driven MLX mediates redox balance maintenance via SLC7A11 in osteosarcoma.

Guo W, Wang X, Lu B, Yu J, Xu M, Huang R, Cheng M, Yang M, Zhao W, Zou C
Cell death & disease 2023 Jul 17;14(7):439

Functionalized biological metal-organic framework with nanosized coronal structure and hierarchical wrapping pattern for enhanced targeting therapy.

Wang H, Li S, Wang L, Liao Z, Zhang H, Wei T, Dai Z
Chemical engineering journal (Lausanne, Switzerland : 1996) 2023 Jan 15;456:140963

Anacardic acid improves neurological deficits in traumatic brain injury by anti-ferroptosis and anti-inflammation.

Liu Y, Zhao Z, Guo J, Ma Y, Li J, Ji H, Chen Z, Zheng J
Experimental neurology 2023 Dec;370:114568

Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR-RUNX1.

Zhou L, Wu D, Zhou Y, Wang D, Fu H, Huang Q, Qin G, Chen J, Lv J, Lai S, Zhang H, Tang K, Ma J, Fiskesund R, Zhang Y, Zhang X, Huang B
Nature immunology 2023 Dec;24(12):2042-2052

Targeting the Na(+)/K(+) ATPase DR-region with DR-Ab improves doxorubicin-induced cardiotoxicity.

Leng B, Deng L, Tan J, Lee WT, Cao CR, Wang ZP, Huang DJ, Nie X, Bian JS
Free radical biology & medicine 2023 Aug 1;204:38-53

Disordered Maternal and Fetal Iron Metabolism Occurs in Preterm Births in Human.

Liu W, Wu Y, Zhang N, Liu S, Zhou L
Disease markers 2022;2022:1664474

Inhibition of ferroptosis attenuates oligospermia in male Nrf2 knockout mice.

Han P, Wang X, Zhou T, Cheng J, Wang C, Sun F, Zhao X
Free radical biology & medicine 2022 Nov 20;193(Pt 1):421-429

Multistage targeting and dual inhibiting strategies based on bioengineered tumor matrix microenvironment-mediated protein nanocages for enhancing cancer biotherapy.

Hu F, Deng C, Zhou Y, Liu Y, Zhang T, Zhang P, Zhao Z, Miao H, Zheng W, Zhang W, Wang M, Ma X
Bioengineering & translational medicine 2022 May;7(2):e10290

Role of ferroptosis-related genes in coronary atherosclerosis and identification of key genes: integration of bioinformatics analysis and experimental validation.

Meng Q, Xu Y, Ling X, Liu H, Ding S, Wu H, Yan D, Fang X, Li T, Liu Q
BMC cardiovascular disorders 2022 Jul 29;22(1):339

Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction.

Henning Y, Blind US, Larafa S, Matschke J, Fandrey J
Cell death & disease 2022 Jul 29;13(7):662

GSK-3β manipulates ferroptosis sensitivity by dominating iron homeostasis.

Wang L, Ouyang S, Li B, Wu H, Wang F
Cell death discovery 2021 Nov 3;7(1):334

SNX-3 mediates retromer-independent tubular endosomal recycling by opposing EEA-1-facilitated trafficking.

Tian Y, Kang Q, Shi X, Wang Y, Zhang N, Ye H, Xu Q, Xu T, Zhang R
PLoS genetics 2021 Jun;17(6):e1009607

Rab11-mediated post-Golgi transport of the sialyltransferase ST3GAL4 suggests a new mechanism for regulating glycosylation.

Kitano M, Kizuka Y, Sobajima T, Nakano M, Nakajima K, Misaki R, Itoyama S, Harada Y, Harada A, Miyoshi E, Taniguchi N
The Journal of biological chemistry 2021 Jan-Jun;296:100354

A novel signature constructed by ferroptosis-associated genes (FAGs) for the prediction of prognosis in bladder urothelial carcinoma (BLCA) and associated with immune infiltration.

Luan JC, Zeng TY, Zhang QJ, Xia DR, Cong R, Yao LY, Song LB, Zhou X, Zhou X, Chen X, Xia JD, Song NH
Cancer cell international 2021 Aug 6;21(1):414

The transferrin receptor CD71 regulates type II CD38, revealing tight topological compartmentalization of intracellular cyclic ADP-ribose production.

Deng QW, Zhang J, Li T, He WM, Fang L, Lee HC, Zhao YJ
The Journal of biological chemistry 2019 Oct 18;294(42):15293-15303

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 66180-1-Ig( CD71 Antibody) at dilution of 1:2000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The CD71 antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human CD71. This antibody recognizes human antigen. The CD71 antibody has been validated for the following applications: ELISA, IHC, WB, IF analysis.
Appendix: 66180-1-Ig.pdf

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