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- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 14324-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14324-1-AP, RRID:AB_2227901
- Product name
- BCO2 antibody
- Antibody type
- Polyclonal
- Description
- BCO2 antibody (Cat. #14324-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Male-Specific Effects of β-Carotene Supplementation on Lipid Metabolism in the Liver and Gonadal Adipose Tissue of Healthy Mice.
Unveiling BCO2 function in macular pigment metabolism: Mitochondrial processing and expression in the primate retina.
Imaging macular carotenoids and their related proteins in the human retina with confocal resonance Raman and fluorescence microscopy.
The human mitochondrial enzyme BCO2 exhibits catalytic activity toward carotenoids and apocarotenoids.
Carotenoid Lutein Selectively Inhibits Breast Cancer Cell Growth and Potentiates the Effect of Chemotherapeutic Agents through ROS-Mediated Mechanisms.
Ablation of β,β-carotene-9',10'-oxygenase 2 remodels the hypothalamic metabolome leading to metabolic disorders in mice.
Wolfberries potentiate mitophagy and enhance mitochondrial biogenesis leading to prevention of hepatic steatosis in obese mice: the role of AMP-activated protein kinase α2 subunit.
Inactivity of human β,β-carotene-9',10'-dioxygenase (BCO2) underlies retinal accumulation of the human macular carotenoid pigment.
Dietary wolfberry upregulates carotenoid metabolic genes and enhances mitochondrial biogenesis in the retina of db/db diabetic mice.
Oh Y, Kim J, Park YJ, Kim Y
Molecules (Basel, Switzerland) 2025 Feb 15;30(4)
Molecules (Basel, Switzerland) 2025 Feb 15;30(4)
Unveiling BCO2 function in macular pigment metabolism: Mitochondrial processing and expression in the primate retina.
Shen C, Bandara S, Imanishi SS, Kalra M, Imanishi Y, von Lintig J
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Apr;1870(3):159600
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Apr;1870(3):159600
Imaging macular carotenoids and their related proteins in the human retina with confocal resonance Raman and fluorescence microscopy.
Li B, Chang FY, Wan Z, Giauque NA, Addo EK, Bernstein PS
Experimental eye research 2024 Oct;247:110043
Experimental eye research 2024 Oct;247:110043
The human mitochondrial enzyme BCO2 exhibits catalytic activity toward carotenoids and apocarotenoids.
Thomas LD, Bandara S, Parmar VM, Srinivasagan R, Khadka N, Golczak M, Kiser PD, von Lintig J
The Journal of biological chemistry 2020 Nov 13;295(46):15553-15565
The Journal of biological chemistry 2020 Nov 13;295(46):15553-15565
Carotenoid Lutein Selectively Inhibits Breast Cancer Cell Growth and Potentiates the Effect of Chemotherapeutic Agents through ROS-Mediated Mechanisms.
Gong X, Smith JR, Swanson HM, Rubin LP
Molecules (Basel, Switzerland) 2018 Apr 14;23(4)
Molecules (Basel, Switzerland) 2018 Apr 14;23(4)
Ablation of β,β-carotene-9',10'-oxygenase 2 remodels the hypothalamic metabolome leading to metabolic disorders in mice.
Guo X, Wu L, Lyu Y, Chowanadisai W, Clarke SL, Lucas EA, Smith BJ, He H, Wang W, Medeiros DM, Lin D
The Journal of nutritional biochemistry 2017 Aug;46:74-82
The Journal of nutritional biochemistry 2017 Aug;46:74-82
Wolfberries potentiate mitophagy and enhance mitochondrial biogenesis leading to prevention of hepatic steatosis in obese mice: the role of AMP-activated protein kinase α2 subunit.
Lin D, He H, Ji H, Willis J, Willard L, Jiang Y, Medeiros DM, Wark L, Han J, Liu Y, Lu B
Molecular nutrition & food research 2014 May;58(5):1005-15
Molecular nutrition & food research 2014 May;58(5):1005-15
Inactivity of human β,β-carotene-9',10'-dioxygenase (BCO2) underlies retinal accumulation of the human macular carotenoid pigment.
Li B, Vachali PP, Gorusupudi A, Shen Z, Sharifzadeh H, Besch BM, Nelson K, Horvath MM, Frederick JM, Baehr W, Bernstein PS
Proceedings of the National Academy of Sciences of the United States of America 2014 Jul 15;111(28):10173-8
Proceedings of the National Academy of Sciences of the United States of America 2014 Jul 15;111(28):10173-8
Dietary wolfberry upregulates carotenoid metabolic genes and enhances mitochondrial biogenesis in the retina of db/db diabetic mice.
Yu H, Wark L, Ji H, Willard L, Jaing Y, Han J, He H, Ortiz E, Zhang Y, Medeiros DM, Lin D
Molecular nutrition & food research 2013 Jul;57(7):1158-69
Molecular nutrition & food research 2013 Jul;57(7):1158-69
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- L02 cells were subjected to SDS PAGE followed by western blot with 14324-1-AP(BCO2 antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using BCO2 antibody 14324-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 14324-1-AP(BCO2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 14324-1-AP(BCO2 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
