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Learn21146-1-AP
antibody from Proteintech Group
Targeting: LARS1
FLJ10595, FLJ21788, HSPC192, LARS, LEUS, RNTLS
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 21146-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21146-1-AP, RRID:AB_10733878
- Product name
- LARS antibody
- Antibody type
- Polyclonal
- Description
- LARS antibody (Cat. #21146-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references LARS promotes osteosarcoma proliferation through leucine-dependent PRIM2 translation and DNA replication activation.
Identification of amino acid metabolism-related gene Leucyl-tRNA synthetase 1 (LARS1) as a potential prognostic and therapeutic target in hepatocellular carcinoma.
LARS1 lactylation inhibits autophagy by activating mTORC1 to promote podocytes injury in diabetic kidney disease.
Caloric restriction exacerbates renal post-ischemic injury and fibrosis by modulating mTORC1 signaling and autophagy.
A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation.
LARS1 is a Prognostic Biomarker and Exhibits a Correlation with Immune Infiltrates in Hepatocellular Carcinoma.
Prognostic and chemotherapeutic response prediction by proliferation essential gene signature: Investigating POLE2 in bladder cancer progression and cisplatin resistance.
Mitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 Deubiquitination.
Dickkopf 4 Alone and in Combination with Leucyl-tRNA Synthetase as a Good Prognostic Biomarker for Human Colorectal Cancer.
Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA.
METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism.
A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids.
Multimodal cotranslational interactions direct assembly of the human multi-tRNA synthetase complex.
KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.
PGC-1α Regulates Cell Proliferation, Migration, and Invasion by Modulating Leucyl-tRNA Synthetase 1 Expression in Human Colorectal Cancer Cells.
Identification of LARS as an essential gene for osteosarcoma proliferation through large-Scale CRISPR-Cas9 screening database and experimental verification.
A genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylation.
Bai G, Zhang L, Zhao M, Zhang J, Chen W
Journal of experimental & clinical cancer research : CR 2026 Mar 14;45(1)
Journal of experimental & clinical cancer research : CR 2026 Mar 14;45(1)
Identification of amino acid metabolism-related gene Leucyl-tRNA synthetase 1 (LARS1) as a potential prognostic and therapeutic target in hepatocellular carcinoma.
Shi Q, Chi Y, Peng Z, Li C, Zhao J, Zhang J
Frontiers in oncology 2025;15:1675018
Frontiers in oncology 2025;15:1675018
LARS1 lactylation inhibits autophagy by activating mTORC1 to promote podocytes injury in diabetic kidney disease.
Fan Z, Zhang Y, Yuan L, Gao Y, Tian X, Tian J, Wan J, Li B, Wang X, Wang S, Zhang L, Wang L, Zhou P, Liu W
Cellular signalling 2025 Oct;134:111955
Cellular signalling 2025 Oct;134:111955
Caloric restriction exacerbates renal post-ischemic injury and fibrosis by modulating mTORC1 signaling and autophagy.
Shi L, Zha H, Zhao J, An H, Huang H, Xia Y, Yan Z, Song Z, Zhu J
Redox biology 2025 Mar;80:103500
Redox biology 2025 Mar;80:103500
A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation.
Ali RH, Orellana EA, Lee SH, Chae YC, Chen Y, Clauwaert J, Kennedy AL, Gutierrez AE, Papke DJ, Valenzuela M, Silverman B, Falzetta A, Ficarro SB, Marto JA, Fletcher CDM, Perez-Atayde A, Alcindor T, Shimamura A, Prensner JR, Gregory RI, Gutierrez A
Molecular cell 2025 Mar 6;85(5):948-961.e11
Molecular cell 2025 Mar 6;85(5):948-961.e11
LARS1 is a Prognostic Biomarker and Exhibits a Correlation with Immune Infiltrates in Hepatocellular Carcinoma.
Fan L, Qin Z, Wu D, Yang Y, Zhang Y, Xie B, Qian J, Wei J, Wang Z, Yang P, Qian Z, Yuan M, Zhu Z, Tan Y, Tan Y
International journal of general medicine 2024;17:2203-2221
International journal of general medicine 2024;17:2203-2221
Prognostic and chemotherapeutic response prediction by proliferation essential gene signature: Investigating POLE2 in bladder cancer progression and cisplatin resistance.
Yu L, Lin N, Ye Y, Zhou S, Xu Y, Chen J, Zhuang W, Wang Q
Journal of Cancer 2024;15(6):1734-1749
Journal of Cancer 2024;15(6):1734-1749
Mitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 Deubiquitination.
Yin Y, Li Y, Ma B, Ren C, Zhao S, Li J, Gong Y, Yang H, Li J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(43):e2405620
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(43):e2405620
Dickkopf 4 Alone and in Combination with Leucyl-tRNA Synthetase as a Good Prognostic Biomarker for Human Colorectal Cancer.
Park SJ, Cho JG, Han SH, Kim YM, Pak MG, Roh MS, Park JI
BioMed research international 2023;2023:9057735
BioMed research international 2023;2023:9057735
Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA.
Malnar Črnigoj M, Čerček U, Yin X, Ho MT, Repic Lampret B, Neumann M, Hermann A, Rouleau G, Suter B, Mayr M, Rogelj B
Nature communications 2023 Sep 16;14(1):5764
Nature communications 2023 Sep 16;14(1):5764
METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism.
Han L, Dong L, Leung K, Zhao Z, Li Y, Gao L, Chen Z, Xue J, Qing Y, Li W, Pokharel SP, Gao M, Chen M, Shen C, Tan B, Small A, Wang K, Zhang Z, Qin X, Yang L, Wunderlich M, Zhang B, Mulloy JC, Marcucci G, Chen CW, Wei M, Su R, Chen J, Deng X
Cell stem cell 2023 Jan 5;30(1):52-68.e13
Cell stem cell 2023 Jan 5;30(1):52-68.e13
A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids.
Gollwitzer P, Grützmacher N, Wilhelm S, Kümmel D, Demetriades C
Nature cell biology 2022 Sep;24(9):1394-1406
Nature cell biology 2022 Sep;24(9):1394-1406
Multimodal cotranslational interactions direct assembly of the human multi-tRNA synthetase complex.
Khan K, Long B, Gogonea V, Deshpande GM, Vasu K, Fox PL
Proceedings of the National Academy of Sciences of the United States of America 2022 Sep 6;119(36):e2205669119
Proceedings of the National Academy of Sciences of the United States of America 2022 Sep 6;119(36):e2205669119
KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.
Yan G, Li X, Zheng Z, Gao W, Chen C, Wang X, Cheng Z, Yu J, Zou G, Farooq MZ, Zhu X, Zhu W, Zhong Q, Yan X
Autophagy 2022 Dec;18(12):2799-2816
Autophagy 2022 Dec;18(12):2799-2816
PGC-1α Regulates Cell Proliferation, Migration, and Invasion by Modulating Leucyl-tRNA Synthetase 1 Expression in Human Colorectal Cancer Cells.
Cho JG, Park SJ, Han SH, Park JI
Cancers 2022 Dec 27;15(1)
Cancers 2022 Dec 27;15(1)
Identification of LARS as an essential gene for osteosarcoma proliferation through large-Scale CRISPR-Cas9 screening database and experimental verification.
Chen W, Lin Y, Jiang M, Wang Q, Shu Q
Journal of translational medicine 2022 Aug 12;20(1):355
Journal of translational medicine 2022 Aug 12;20(1):355
A genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylation.
Papageorgiou A, Rapley J, Mesirov JP, Tamayo P, Avruch J
PloS one 2015;10(3):e0116096
PloS one 2015;10(3):e0116096
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Raji cells were subjected to SDS PAGE followed by western blot with 21146-1-AP(LARS antibody) at dilution of 1:2000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using LARS antibody 21146-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon using 21146-1-AP(LARS antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon using 21146-1-AP(LARS antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
