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antibody from antibodies-online
Targeting: SKP1
EMC19, MGC34403, OCP-II, OCP2, p19A, SKP1A, TCEB1L
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Product number
- ABIN357264 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-S-Phase Kinase-Associated Protein 1 (SKP1) (Middle Region) antibody
- Antibody type
- Polyclonal
- Description
- Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Epitope
- Middle Region
- Vial size
- 0.4 mL
- Storage
- Store the antibody at 2 - 8°C up to one month or (in aliquots) at -20°C for longer.
- Handling
- Avoid repeated freezing and thawing.
Submitted references Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase.
In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation.
Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.
Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro.
Wu G, Xu G, Schulman BA, Jeffrey PD, Harper JW, Pavletich NP
Molecular cell 2003 Jun;11(6):1445-56
Molecular cell 2003 Jun;11(6):1445-56
In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation.
Piva R, Liu J, Chiarle R, Podda A, Pagano M, Inghirami G
Molecular and cellular biology 2002 Dec;22(23):8375-87
Molecular and cellular biology 2002 Dec;22(23):8375-87
Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.
Matsuzawa SI, Reed JC
Molecular cell 2001 May;7(5):915-26
Molecular cell 2001 May;7(5):915-26
Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
Schulman BA, Carrano AC, Jeffrey PD, Bowen Z, Kinnucan ER, Finnin MS, Elledge SJ, Harper JW, Pagano M, Pavletich NP
Nature 2000 Nov 16;408(6810):381-6
Nature 2000 Nov 16;408(6810):381-6
The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro.
Winston JT, Strack P, Beer-Romero P, Chu CY, Elledge SJ, Harper JW
Genes & development 1999 Feb 1;13(3):270-83
Genes & development 1999 Feb 1;13(3):270-83
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