F2RL1

This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. This protein is also important in the inflammatory response, as well as innate and adaptive immunity. [provided by RefSeq, Jun 2016]

Description

F2R like trypsin receptor 1

Tissue specificity

Tissue enhanced (intestine, stomach)

Subcell location

Plasma membrane

Predicted location

Membrane

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Transporters

Chromosome

5 (76818933 - 76835315)

Ensembl ID

ENSG00000164251  (ver. 103.38)

Orthologs

Mouse F2rl1: ENSMUSG00000021678

UniProt

P55085

neXtProt

NX_P55085

Human splice variants
Mouse splice variants

Protein structure