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- References [18]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 13033-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13033-1-AP, RRID:AB_2301284
- Product name
- SACM1L antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SACM1L antibody (Cat. #13033-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Nutrient-regulated control of lysosome function by signaling lipid conversion.
Lipid phosphatase SAC1 suppresses hepatitis B virus replication through promoting autophagic degradation of virions.
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING.
Profiling of purified autophagic vesicle degradome in the maturing and aging brain.
Elucidation of the Cellular Interactome of African Swine Fever Virus Fusion Proteins and Identification of Potential Therapeutic Targets.
Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity.
Addiction to Golgi-resident PI4P synthesis in chromosome 1q21.3-amplified lung adenocarcinoma cells.
The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER-Golgi membrane contact sites.
PtdIns4P restriction by hydrolase SAC1 decides specific fusion of autophagosomes with lysosomes.
Global mapping of Salmonella enterica-host protein-protein interactions during infection.
Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking.
Sac1 Phosphoinositide Phosphatase Regulates Foam Cell Formation by Modulating SR-A Expression in Macrophages.
An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity.
The activity of Sac1 across ER-TGN contact sites requires the four-phosphate-adaptor-protein-1.
Phosphoinositide phosphatase Sac3 regulates the cell surface expression of scavenger receptor A and formation of lipid droplets in macrophages.
Regulation of CD44 expression and focal adhesion by Golgi phosphatidylinositol 4-phosphate in breast cancer.
Phosphatidylinositol 4-phosphate in the Golgi apparatus regulates cell-cell adhesion and invasive cell migration in human breast cancer.
JNK3 couples the neuronal stress response to inhibition of secretory trafficking.
Ebner M, Puchkov D, López-Ortega O, Muthukottiappan P, Su Y, Schmied C, Zillmann S, Nikonenko I, Koddebusch J, Dornan GL, Lucht MT, Koka V, Jang W, Koch PA, Wallroth A, Lehmann M, Brügger B, Pende M, Winter D, Haucke V
Cell 2023 Nov 22;186(24):5328-5346.e26
Cell 2023 Nov 22;186(24):5328-5346.e26
Lipid phosphatase SAC1 suppresses hepatitis B virus replication through promoting autophagic degradation of virions.
Zheng J, Deng Y, Wei Z, Zou H, Wen X, Cai J, Zhang S, Jia B, Lu M, Lu K, Lin Y
Antiviral research 2023 May;213:105601
Antiviral research 2023 May;213:105601
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING.
Fang R, Jiang Q, Jia X, Jiang Z
Immunity 2023 Mar 14;56(3):500-515.e6
Immunity 2023 Mar 14;56(3):500-515.e6
Profiling of purified autophagic vesicle degradome in the maturing and aging brain.
Kallergi E, Siva Sankar D, Matera A, Kolaxi A, Paolicelli RC, Dengjel J, Nikoletopoulou V
Neuron 2023 Aug 2;111(15):2329-2347.e7
Neuron 2023 Aug 2;111(15):2329-2347.e7
Elucidation of the Cellular Interactome of African Swine Fever Virus Fusion Proteins and Identification of Potential Therapeutic Targets.
García-Dorival I, Cuesta-Geijo MÁ, Galindo I, Del Puerto A, Barrado-Gil L, Urquiza J, Alonso C
Viruses 2023 Apr 29;15(5)
Viruses 2023 Apr 29;15(5)
Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity.
Gao Y, Zheng X, Chang B, Lin Y, Huang X, Wang W, Ding S, Zhan W, Wang S, Xiao B, Huo L, Yu Y, Chen Y, Gong R, Wu Y, Zhang R, Zhong L, Wang X, Chen Q, Gao S, Jiang Z, Wei D, Kang T
Cell research 2022 Dec;32(12):1086-1104
Cell research 2022 Dec;32(12):1086-1104
Addiction to Golgi-resident PI4P synthesis in chromosome 1q21.3-amplified lung adenocarcinoma cells.
Shi L, Tan X, Liu X, Yu J, Bota-Rabassedas N, Niu Y, Luo J, Xi Y, Zong C, Creighton CJ, Glenn JS, Wang J, Kurie JM
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 22;118(25)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 22;118(25)
The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER-Golgi membrane contact sites.
Wakana Y, Hayashi K, Nemoto T, Watanabe C, Taoka M, Angulo-Capel J, Garcia-Parajo MF, Kumata H, Umemura T, Inoue H, Arasaki K, Campelo F, Tagaya M
The Journal of cell biology 2021 Jan 4;220(1)
The Journal of cell biology 2021 Jan 4;220(1)
PtdIns4P restriction by hydrolase SAC1 decides specific fusion of autophagosomes with lysosomes.
Zhang H, Zhou J, Xiao P, Lin Y, Gong X, Liu S, Xu Q, Wang M, Ren H, Lu M, Wang Y, Zhu J, Xie Z, Li H, Lu K
Autophagy 2021 Aug;17(8):1907-1917
Autophagy 2021 Aug;17(8):1907-1917
Global mapping of Salmonella enterica-host protein-protein interactions during infection.
Walch P, Selkrig J, Knodler LA, Rettel M, Stein F, Fernandez K, Viéitez C, Potel CM, Scholzen K, Geyer M, Rottner K, Steele-Mortimer O, Savitski MM, Holden DW, Typas A
Cell host & microbe 2021 Aug 11;29(8):1316-1332.e12
Cell host & microbe 2021 Aug 11;29(8):1316-1332.e12
Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking.
Casas M, Fadó R, Domínguez JL, Roig A, Kaku M, Chohnan S, Solé M, Unzeta M, Miñano-Molina AJ, Rodríguez-Álvarez J, Dickson EJ, Casals N
The Journal of cell biology 2020 Oct 5;219(10)
The Journal of cell biology 2020 Oct 5;219(10)
Sac1 Phosphoinositide Phosphatase Regulates Foam Cell Formation by Modulating SR-A Expression in Macrophages.
Nigorikawa K, Matsumura T, Sakamoto H, Morioka S, Kofuji S, Takasuga S, Hazeki K
Biological & pharmaceutical bulletin 2019;42(6):923-928
Biological & pharmaceutical bulletin 2019;42(6):923-928
An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity.
Schwenk J, Boudkkazi S, Kocylowski MK, Brechet A, Zolles G, Bus T, Costa K, Kollewe A, Jordan J, Bank J, Bildl W, Sprengel R, Kulik A, Roeper J, Schulte U, Fakler B
Neuron 2019 Nov 20;104(4):680-692.e9
Neuron 2019 Nov 20;104(4):680-692.e9
The activity of Sac1 across ER-TGN contact sites requires the four-phosphate-adaptor-protein-1.
Venditti R, Masone MC, Rega LR, Di Tullio G, Santoro M, Polishchuk E, Serrano IC, Olkkonen VM, Harada A, Medina DL, La Montagna R, De Matteis MA
The Journal of cell biology 2019 Mar 4;218(3):783-797
The Journal of cell biology 2019 Mar 4;218(3):783-797
Phosphoinositide phosphatase Sac3 regulates the cell surface expression of scavenger receptor A and formation of lipid droplets in macrophages.
Morioka S, Nigorikawa K, Hazeki K, Ohmura M, Sakamoto H, Matsumura T, Takasuga S, Hazeki O
Experimental cell research 2017 Aug 15;357(2):252-259
Experimental cell research 2017 Aug 15;357(2):252-259
Regulation of CD44 expression and focal adhesion by Golgi phosphatidylinositol 4-phosphate in breast cancer.
Ijuin T, Takeuchi Y, Shimono Y, Fukumoto M, Tokuda E, Takenawa T
Cancer science 2016 Jul;107(7):981-90
Cancer science 2016 Jul;107(7):981-90
Phosphatidylinositol 4-phosphate in the Golgi apparatus regulates cell-cell adhesion and invasive cell migration in human breast cancer.
Tokuda E, Itoh T, Hasegawa J, Ijuin T, Takeuchi Y, Irino Y, Fukumoto M, Takenawa T
Cancer research 2014 Jun 1;74(11):3054-66
Cancer research 2014 Jun 1;74(11):3054-66
JNK3 couples the neuronal stress response to inhibition of secretory trafficking.
Yang G, Zhou X, Zhu J, Liu R, Zhang S, Coquinco A, Chen Y, Wen Y, Kojic L, Jia W, Cynader MS
Science signaling 2013 Jul 9;6(283):ra57
Science signaling 2013 Jul 9;6(283):ra57
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human kidney tissue were subjected to SDS PAGE followed by western blot with 13033-1-AP(SACM1L antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 13033-1-AP(SACM1L antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SACM1L antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SACM1L. This antibody recognizes human,mouse,rat antigen. The SACM1L antibody has been validated for the following applications: ELISA, WB, IHC analysis.
