Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [3]
- Other assay [1]
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Validation data
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- Product number
- 38-8000 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Claudin 18 Polyclonal Antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.25 mg/mL
- Storage
- -20°C
Submitted references The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms.
Frequent CLDN18-ARHGAP fusion in highly metastatic diffuse-type gastric cancer with relatively early onset.
Receptor for advanced glycation endproducts (RAGE) maintains pulmonary structure and regulates the response to cigarette smoke.
P2X7R-dependent regulation of glycogen synthase kinase 3β and claudin-18 in alveolar epithelial type I cells of mice lung.
Expression of claudins 7 and 18 in pancreatic ductal adenocarcinoma: association with features of differentiation.
Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation.
Claudins 10 and 18 are predominantly expressed in lung adenocarcinomas and in tumors of nonsmokers.
Claudin-18 is an early-stage marker of pancreatic carcinogenesis.
S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF.
Balbinot C, Armant O, Elarouci N, Marisa L, Martin E, De Clara E, Onea A, Deschamps J, Beck F, Freund JN, Duluc I
The Journal of experimental medicine 2018 Mar 5;215(3):911-926
The Journal of experimental medicine 2018 Mar 5;215(3):911-926
Frequent CLDN18-ARHGAP fusion in highly metastatic diffuse-type gastric cancer with relatively early onset.
Tanaka A, Ishikawa S, Ushiku T, Yamazawa S, Katoh H, Hayashi A, Kunita A, Fukayama M
Oncotarget 2018 Jun 29;9(50):29336-29350
Oncotarget 2018 Jun 29;9(50):29336-29350
Receptor for advanced glycation endproducts (RAGE) maintains pulmonary structure and regulates the response to cigarette smoke.
Wolf L, Herr C, Niederstraßer J, Beisswenger C, Bals R
PloS one 2017;12(7):e0180092
PloS one 2017;12(7):e0180092
P2X7R-dependent regulation of glycogen synthase kinase 3β and claudin-18 in alveolar epithelial type I cells of mice lung.
Barth K, Bläsche R, Neißer A, Bramke S, Frank JA, Kasper M
Histochemistry and cell biology 2016 Dec;146(6):757-768
Histochemistry and cell biology 2016 Dec;146(6):757-768
Expression of claudins 7 and 18 in pancreatic ductal adenocarcinoma: association with features of differentiation.
Soini Y, Takasawa A, Eskelinen M, Juvonen P, Kärjä V, Hasegawa T, Murata M, Tanaka S, Kojima T, Sawada N
Journal of clinical pathology 2012 May;65(5):431-6
Journal of clinical pathology 2012 May;65(5):431-6
Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation.
Linares GR, Brommage R, Powell DR, Xing W, Chen ST, Alshbool FZ, Lau KH, Wergedal JE, Mohan S
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012 Jul;27(7):1553-65
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012 Jul;27(7):1553-65
Claudins 10 and 18 are predominantly expressed in lung adenocarcinomas and in tumors of nonsmokers.
Merikallio H, Pääkkö P, Harju T, Soini Y
International journal of clinical and experimental pathology 2011;4(7):667-73
International journal of clinical and experimental pathology 2011;4(7):667-73
Claudin-18 is an early-stage marker of pancreatic carcinogenesis.
Tanaka M, Shibahara J, Fukushima N, Shinozaki A, Umeda M, Ishikawa S, Kokudo N, Fukayama M
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2011 Oct;59(10):942-52
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2011 Oct;59(10):942-52
S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF.
Gon Y, Wood MR, Kiosses WB, Jo E, Sanna MG, Chun J, Rosen H
Proceedings of the National Academy of Sciences of the United States of America 2005 Jun 28;102(26):9270-5
Proceedings of the National Academy of Sciences of the United States of America 2005 Jun 28;102(26):9270-5
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot analysis of mouse lung homogenates using Claudin-18 (C-Term) Polyclonal Antibody, Rabbit (C-term) (Product # 38-8000).
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemistry analysis of Claudin-18 (C-Term) showing staining in the membrane of paraffin-embedded human lung tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10 mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature, washed with ddH2O and PBS, and then probed with a Claudin-18 (C-Term) Rabbit Polyclonal Antibody (Product # 38-8000) diluted in 3% BSA-PBS at a dilution of 1:50 overnight at 4°C in a humidified chamber. Tissues were washed extensively in PBST and detection was performed using an HRP-conjugated secondary antibody followed by colorimetric detection using a DAB kit. Tissues were counterstained with hematoxylin and dehydrated with ethanol and xylene to prep for mounting.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemistry analysis of Claudin-18 (C-Term) showing staining in the membrane of paraffin-embedded human stomach tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature, washed with ddH2O and PBS, and then probed with a Claudin-18 (C-Term) Rabbit Polyclonal Antibody (Product # 38-8000) diluted in 3% BSA-PBS at a dilution of 1:100 overnight at 4ºC in a humidified chamber. Tissues were washed extensively in PBST and detection was performed using an HRP-conjugated secondary antibody followed by colorimetric detection using a DAB kit. Tissues were counterstained with hematoxylin and dehydrated with ethanol and xylene to prep for mounting.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemistry analysis of Claudin-18 (C-Term) showing staining in the membrane of paraffin-embedded Mouse lung tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature, washed with ddH2O and PBS, and then probed with a Claudin-18 (C-Term) Rabbit Polyclonal Antibody (Product # 38-8000) diluted in 3% BSA-PBS at a dilution of 1:20 overnight at 4ºC in a humidified chamber. Tissues were washed extensively in PBST and detection was performed using an HRP-conjugated secondary antibody followed by colorimetric detection using a DAB kit. Tissues were counterstained with hematoxylin and dehydrated with ethanol and xylene to prep for mounting.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Fig 3 RAGE promotes the differentiation and formation of an intact barrier function in primary murine alveolar epithelial cells. Alveolar epithelial cells were isolated from WT and RAGE -/- mice and analyzed in an air-liquid interface culture system. (A) TEER of isolated alveolar epithelial cells was measured for a period of five days; n = 12 per group. Relative mRNA induction of alveolar epithelial type 2 cell marker surfactant protein C (B), alveolar epithelial type 1 cell marker aquaporin-5 (AQP5) (C) and the tight junction proteins claudin 18 (D), ZO-1 (E) and occludin (F) was determined by qRT-PCR; n = 6 per group. The proteins of cell lysate of alveolar epithelial cells at day 2 and 4 post isolation were separated by SDS-PAGE and stained with antibodies against alpha-Tubulin (alphaTub), aquaporin-5 (AQP5), pro-surfactant protein C (Sp-C), and claudin 18 (Cldn18) (G). The bands of the blot were densitometrically analyzed and the results are shown for AQP5 (H), SP-C (I), and Cldn18 (J). Data are shown as mean +- SEM. *p < 0.05; **p < 0.01 and ***p < 0.001.