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- Antigen structure
- References [138]
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- Product number
- 10201-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10201-2-AP, RRID:AB_671515
- Product name
- ubiquitin antibody
- Antibody type
- Polyclonal
- Description
- ubiquitin antibody (Cat. #10201-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references RNF2 promotes the progression of colon cancer by regulating ubiquitination and degradation of IRF4.
Choline-induced SLC5A7 impairs colorectal cancer growth by stabilizing p53 protein.
Hemin enhances radiosensitivity of lung cancer cells through ferroptosis.
Autophagy Regulates VDAC3 Ubiquitination by FBXW7 to Promote Erastin-Induced Ferroptosis in Acute Lymphoblastic Leukemia.
ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells.
Simultaneous silencing Aurora-A and UHRF1 inhibits colorectal cancer cell growth through regulating expression of DNMT1 and STAT1.
MAD2B-mediated cell cycle reentry of podocytes is involved in the pathogenesis of FSGS.
Pentamidine Inhibits Ovarian Cancer Cell Proliferation and Migration by Maintaining Stability of PTEN in vitro.
Deltex3 inhibits Epithelial Mesenchymal Transition in Papillary Thyroid Carcinoma via promoting ubiquitination of XRCC5 to regulate the AKT signal pathway.
Nogo-B receptor is required for stabilizing TGF-β type I receptor and promotes the TGF-β1-induced epithelial-to-mesenchymal transition of non-small cell lung cancer.
Samotolisib Attenuates Acute Liver Injury Through Inhibiting Caspase-11-Mediated Pyroptosis Via Regulating E3 Ubiquitin Ligase Nedd4.
Autophagic Inhibition of Caveolin-1 by Compound Phyllanthus urinaria L. Activates Ubiquitination and Proteasome Degradation of β-catenin to Suppress Metastasis of Hepatitis B-Associated Hepatocellular Carcinoma.
Hepatitis B Surface Antigen Suppresses the Activation of Nuclear Factor Kappa B Pathway via Interaction With the TAK1-TAB2 Complex.
YY1-mediated reticulocalbin-2 upregulation promotes the hepatocellular carcinoma progression via activating MYC signaling.
TRIM50 Suppresses Pancreatic Cancer Progression and Reverses the Epithelial-Mesenchymal Transition via Facilitating the Ubiquitous Degradation of Snail1.
CDC20 promotes bone formation via APC/C dependent ubiquitination and degradation of p65.
Proteasome inhibition by bortezomib parallels a reduction in head and neck cancer cells growth, and an increase in tumor-infiltrating immune cells.
Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex.
Hydrogen sulphide reduced the accumulation of lipid droplets in cardiac tissues of db/db mice via Hrd1 S-sulfhydration.
Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy: Dynamic analysis on cytotoxic effects of LW-218.
Melatonin potentiates the cytotoxic effect of Neratinib in HER2+ breast cancer through promoting endocytosis and lysosomal degradation of HER2.
NudCL2 is an autophagy receptor that mediates selective autophagic degradation of CP110 at mother centrioles to promote ciliogenesis.
DOC-2/DAB2 interactive protein destabilizes c-Myc to impair the growth and self-renewal of colon tumor-repopulating cells.
Glutathione-responsive copper-disulfiram nanoparticles for enhanced tumor chemotherapy.
Golgi Phosphoprotein 3 Confers Radioresistance via Stabilizing EGFR in Lung Adenocarcinoma.
Efficacy and long-term safety of CRISPR/Cas9 genome editing in the SOD1-linked mouse models of ALS.
Gankyrin activates the hedgehog signalling to drive metastasis in osteosarcoma.
Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2/ARE axis.
Osteocrin, a novel myokine, prevents diabetic cardiomyopathy via restoring proteasomal activity.
PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53.
Nedd4-2 haploinsufficiency in mice causes increased seizure susceptibility and impaired Kir4.1 ubiquitination.
USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites.
Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/TfR1 pathway in the rat hearts after ischemia/reperfusion.
Baicalein suppresses growth of non-small cell lung carcinoma by targeting MAP4K3.
Polyglucosan body myopathy 1 may cause cognitive impairment: a case report from China.
Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice.
FV-429 induces autophagy blockage and lysosome-dependent cell death of T-cell malignancies via lysosomal dysregulation.
Dysregulation of USP18/FTO/PYCR1 signaling network promotes bladder cancer development and progression.
Role of the E3 ubiquitin ligase HRD1 in the regulation of serotonin transporter function.
FAT10 promotes the progression of bladder cancer by upregulating HK2 through the EGFR/AKT pathway.
SQSTM1/ p62 oligomerization contributes to Aβ-induced inhibition of Nrf2 signaling.
The novel ZEB1-upregulated protein PRTG induced by Helicobacter pylori infection promotes gastric carcinogenesis through the cGMP/PKG signaling pathway.
DUOX2 promotes the progression of colorectal cancer cells by regulating the AKT pathway and interacting with RPL3.
Upstream open reading frame with NOTCH2NLC GGC expansion generates polyglycine aggregates and disrupts nucleocytoplasmic transport: implications for polyglycine diseases.
Hsa_circ_0024093 accelerates VSMC proliferation via miR-4677-3p/miR-889-3p/USP9X/YAP1 axis in in vitro model of lower extremity ASO.
SPOCK1 promotes metastasis in pancreatic cancer via NF-κB-dependent epithelial-mesenchymal transition by interacting with IκB-α.
Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling.
Increased AT1 receptor expression mediates vasoconstriction leading to hypertension in Snx1-/- mice.
Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage.
Ubiquitin-dependent Argonauteprotein MEL1 degradation is essential for rice sporogenesis and phasiRNA target regulation.
Anaplasma phagocytophilum AptA enhances the UPS, autophagy, and anti-apoptosis of host cells by PSMG3.
Anti-tumor activity of a novel proteasome inhibitor D395 against multiple myeloma and its lower cardiotoxicity compared with carfilzomib.
FBXL10 promotes ERRα protein stability and proliferation of breast cancer cells by enhancing the mono-ubiquitylation of ERRα.
Cancer Cell enters reversible quiescence through Intracellular Acidification to resist Paclitaxel Cytotoxicity.
Parkin interacts with Mitofilin to increase dopaminergic neuron death in response to Parkinson's disease-related stressors.
HDAC6, A Novel Cargo for Autophagic Clearance of Stress Granules, Mediates the Repression of the Type I Interferon Response During Coxsackievirus A16 Infection.
Ubiquitin E3 Ligase c-Cbl Is a Host Negative Regulator of Nef Protein of HIV-1.
SPOP attenuates migration and invasion of choriocarcinoma cells by promoting DHX9 degradation.
WDHD1 Leads to Cisplatin Resistance by Promoting MAPRE2 Ubiquitination in Lung Adenocarcinoma.
p53 Affects PGC1α Stability Through AKT/GSK-3β to Enhance Cisplatin Sensitivity in Non-Small Cell Lung Cancer.
Tobramycin suppresses HUWE1 degradation to control MCL-1 stability during tumour development.
Crosstalk between cardiomyocytes and noncardiomyocytes is essential to prevent cardiomyocyte apoptosis induced by proteasome inhibition.
The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models.
Involvement of p53 Acetylation in Growth Suppression of Cutaneous T-Cell Lymphomas Induced by HDAC Inhibition.
LINC00452 promotes ovarian carcinogenesis through increasing ROCK1 by sponging miR-501-3p and suppressing ubiquitin-mediated degradation.
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis.
SUMOylation Protects FASN Against Proteasomal Degradation in Breast Cancer Cells Treated with Grape Leaf Extract.
α-synuclein strains that cause distinct pathologies differentially inhibit proteasome.
Arabidopsis SINAT Proteins Control Autophagy by Mediating Ubiquitylation and Degradation of ATG13.
Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages.
A robust TDP-43 knock-in mouse model of ALS.
Voltage-gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation.
Lanosterol modulates proteostasis via dissolving cytosolic sequestosomes/aggresome-like induced structures.
Hydrogen sulfide regulates muscle RING finger-1 protein S-sulfhydration at Cys(44) to prevent cardiac structural damage in diabetic cardiomyopathy.
Down-Regulated CUEDC2 Increases GDNF Expression by Stabilizing CREB Through Reducing Its Ubiquitination in Glioma.
MAFG-AS1 promotes tumor progression via regulation of the HuR/PTBP1 axis in bladder urothelial carcinoma.
PHLDA1 promotes microglia-mediated neuroinflammation via regulating K63-linked ubiquitination of TRAF6.
Hydrogen sulphide ameliorating skeletal muscle atrophy in db/db mice via Muscle RING finger 1 S-sulfhydration.
Long non-coding RNA LOC100133669 promotes cell proliferation in oesophageal squamous cell carcinoma.
Exogenous H2S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.
Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6/TAK1/MAPK and Nrf2 Signaling Pathway.
The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein.
STAT3 Regulates the Type I IFN-Mediated Antiviral Response by Interfering with the Nuclear Entry of STAT1.
Long Noncoding RNA-DACH1 (Dachshund Homolog 1) Regulates Cardiac Function by Inhibiting SERCA2a (Sarcoplasmic Reticulum Calcium ATPase 2a).
Cinobufotalin powerfully reversed EBV-miR-BART22-induced cisplatin resistance via stimulating MAP2K4 to antagonize non-muscle myosin heavy chain IIA/glycogen synthase 3β/β-catenin signaling pathway.
Autophagy protects HUVECs against ER stress-mediated apoptosis under simulated microgravity.
The immunoproteasome catalytic β5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation.
Nilotinib: A Tyrosine Kinase Inhibitor Mediates Resistance to Intracellular Mycobacterium Via Regulating Autophagy.
The endogenous retrovirus-derived long noncoding RNA TROJAN promotes triple-negative breast cancer progression via ZMYND8 degradation.
THZ1 suppresses human non-small-cell lung cancer cells in vitro through interference with cancer metabolism.
Fludarabine as an Adjuvant Improves Newcastle Disease Virus-Mediated Antitumor Immunity in Hepatocellular Carcinoma.
Autosomal dominant mitochondrial membrane protein-associated neurodegeneration (MPAN).
Hsp90ab1 stabilizes LRP5 to promote epithelial-mesenchymal transition via activating of AKT and Wnt/β-catenin signaling pathways in gastric cancer progression.
YY1-regulated LINC00152 promotes triple negative breast cancer progression by affecting on stability of PTEN protein.
Kindlin-2 links mechano-environment to proline synthesis and tumor growth.
USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication.
Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy.
Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice.
TRIM59 regulates autophagy through modulating both the transcription and the ubiquitination of BECN1.
M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole.
Pyk2 deficiency potentiates osteoblast differentiation and mineralizing activity in response to estrogen or raloxifene.
14-3-3ζ binds to hepatitis B virus protein X and maintains its protein stability in hepatocellular carcinoma cells.
Downregulation of glycine decarboxylase enhanced cofilin-mediated migration in hepatocellular carcinoma cells.
Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation.
Identification of Residues Controlling Restriction versus Enhancing Activities of IFITM Proteins on Entry of Human Coronaviruses.
CRISPR/Cas9-Targeted Deletion of Polyglutamine in Spinocerebellar Ataxia Type 3-Derived Induced Pluripotent Stem Cells.
Ubiquitin-Specific Protease USP6 Regulates the Stability of the c-Jun Protein.
SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer.
The N-terminal ubiquitin-associated domain of Cezanne is crucial for its function to suppress NF-κB pathway.
Temozolomide-perillyl alcohol conjugate downregulates O6-methylguanin DNA methltransferase via inducing ubiquitination-dependent proteolysis in non-small cell lung cancer.
The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma.
Role of the Ubiquitin C-Terminal Hydrolase L1-Modulated Ubiquitin Proteasome System in Auditory Cortex Senescence.
Endoplasmic Reticulum Stress Is Involved in Cochlear Cell Apoptosis in a Cisplatin-Induced Ototoxicity Rat Model.
HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway.
MDM2 Contributes to High Glucose-Induced Glomerular Mesangial Cell Proliferation and Extracellular Matrix Accumulation via Notch1.
Liposomal honokiol induced lysosomal degradation of Hsp90 client proteins and protective autophagy in both gefitinib-sensitive and gefitinib-resistant NSCLC cells.
Exogenous H2S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.
AMPK Serves as a Therapeutic Target Against Anemia of Inflammation.
A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer.
TRAF Family Proteins Regulate Autophagy Dynamics by Modulating AUTOPHAGY PROTEIN6 Stability in Arabidopsis.
A novel glutaminase inhibitor-968 inhibits the migration and proliferation of non-small cell lung cancer cells by targeting EGFR/ERK signaling pathway.
The N-Terminal of Aquareovirus NS80 Is Required for Interacting with Viral Proteins and Viral Replication.
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness.
Far-infrared promotes burn wound healing by suppressing NLRP3 inflammasome caused by enhanced autophagy.
Nogo-B receptor promotes the chemoresistance of human hepatocellular carcinoma via the ubiquitination of p53 protein.
Proteomic analysis of apoptosis induction by lariciresinol in human HepG2 cells.
The Ubiquitin-like Protein FAT10 Stabilizes eEF1A1 Expression to Promote Tumor Proliferation in a Complex Manner.
Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon.
The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.
DEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase.
The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer.
Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins.
Rock2 promotes the invasion and metastasis of hepatocellular carcinoma by modifying MMP2 ubiquitination and degradation.
Clinicopathologic report of ocular involvement in ALS patients with C9orf72 mutation.
Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility.
Ubiquitin B in cervical cancer: critical for the maintenance of cancer stem-like cell characters.
Downregulation of the ubiquitin-proteasome system in normal colonic macrophages and reinduction in inflammatory bowel disease.
Amyloid precursor protein accumulates in aggresomes in response to proteasome inhibitor.
Wang J, Ouyang X, Zhou Z, Mao S, Niu X, Li H, Xu W, Song Y, Cao J, Lai B
Biochimica et biophysica acta. Molecular cell research 2022 Jan;1869(1):119162
Biochimica et biophysica acta. Molecular cell research 2022 Jan;1869(1):119162
Choline-induced SLC5A7 impairs colorectal cancer growth by stabilizing p53 protein.
Yin Y, Jiang Z, Fu J, Li Y, Fang C, Yin X, Chen Y, Chen N, Li J, Ji Y, Su X, Qiu M, Huang W, Zhang B, Deng H, Dai L
Cancer letters 2022 Jan 28;525:55-66
Cancer letters 2022 Jan 28;525:55-66
Hemin enhances radiosensitivity of lung cancer cells through ferroptosis.
Almahi WA, Yu KN, Mohammed F, Kong P, Han W
Experimental cell research 2022 Jan 1;410(1):112946
Experimental cell research 2022 Jan 1;410(1):112946
Autophagy Regulates VDAC3 Ubiquitination by FBXW7 to Promote Erastin-Induced Ferroptosis in Acute Lymphoblastic Leukemia.
Zhu T, Liu B, Wu D, Xu G, Fan Y
Frontiers in cell and developmental biology 2021;9:740884
Frontiers in cell and developmental biology 2021;9:740884
ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells.
Yang Y, Li C, Gu X, Zhen J, Zhu S, Lv T, Wan Q, Liu Y
Frontiers in cell and developmental biology 2021;9:700195
Frontiers in cell and developmental biology 2021;9:700195
Simultaneous silencing Aurora-A and UHRF1 inhibits colorectal cancer cell growth through regulating expression of DNMT1 and STAT1.
Han J, Chen X, Xu J, Chu L, Li R, Sun N, Jiang Z, Liu H, Ge X, Zheng J, Yang J, Ikezoe T
International journal of medical sciences 2021;18(15):3437-3451
International journal of medical sciences 2021;18(15):3437-3451
MAD2B-mediated cell cycle reentry of podocytes is involved in the pathogenesis of FSGS.
Bao D, Su H, Lei CT, Tang H, Ye C, Xiong W, He FF, Lin JH, Hammes HP, Zhang C
International journal of biological sciences 2021;17(15):4396-4408
International journal of biological sciences 2021;17(15):4396-4408
Pentamidine Inhibits Ovarian Cancer Cell Proliferation and Migration by Maintaining Stability of PTEN in vitro.
Wu Y, Zhang Z, Kou Z
Drug design, development and therapy 2021;15:2857-2868
Drug design, development and therapy 2021;15:2857-2868
Deltex3 inhibits Epithelial Mesenchymal Transition in Papillary Thyroid Carcinoma via promoting ubiquitination of XRCC5 to regulate the AKT signal pathway.
Wang L, Huang Y, Liu C, Guo M, Ma Z, He J, Wang A, Sun X, Liu Z
Journal of Cancer 2021;12(3):860-873
Journal of Cancer 2021;12(3):860-873
Nogo-B receptor is required for stabilizing TGF-β type I receptor and promotes the TGF-β1-induced epithelial-to-mesenchymal transition of non-small cell lung cancer.
Wu D, Zhao B, Song Y, Chi X, Fu H, Guan T, Zhang L, Yang X, Hu K, Huang R, Jin X, Miao QR, Shao S
Journal of Cancer 2021;12(3):717-725
Journal of Cancer 2021;12(3):717-725
Samotolisib Attenuates Acute Liver Injury Through Inhibiting Caspase-11-Mediated Pyroptosis Via Regulating E3 Ubiquitin Ligase Nedd4.
Zhao YY, Wu DM, He M, Zhang F, Zhang T, Liu T, Li J, Li L, Xu Y
Frontiers in pharmacology 2021;12:726198
Frontiers in pharmacology 2021;12:726198
Autophagic Inhibition of Caveolin-1 by Compound Phyllanthus urinaria L. Activates Ubiquitination and Proteasome Degradation of β-catenin to Suppress Metastasis of Hepatitis B-Associated Hepatocellular Carcinoma.
Huang D, Yang B, Yao Y, Liao M, Zhang Y, Zeng Y, Zhang F, Wang N, Tong G
Frontiers in pharmacology 2021;12:659325
Frontiers in pharmacology 2021;12:659325
Hepatitis B Surface Antigen Suppresses the Activation of Nuclear Factor Kappa B Pathway via Interaction With the TAK1-TAB2 Complex.
Deng F, Xu G, Cheng Z, Huang Y, Ma C, Luo C, Yu C, Wang J, Xu X, Liu S, Zhu Y
Frontiers in immunology 2021;12:618196
Frontiers in immunology 2021;12:618196
YY1-mediated reticulocalbin-2 upregulation promotes the hepatocellular carcinoma progression via activating MYC signaling.
Mei C, Jiang X, Gu Y, Wu X, Ma W, Chen X, Wang G, Yao Y, Liu Y, Zhang Z, Yuan Y
American journal of cancer research 2021;11(5):2238-2251
American journal of cancer research 2021;11(5):2238-2251
TRIM50 Suppresses Pancreatic Cancer Progression and Reverses the Epithelial-Mesenchymal Transition via Facilitating the Ubiquitous Degradation of Snail1.
Li R, Zhu L, Peng Y, Zhang X, Dai C, Liu D
Frontiers in oncology 2021;11:695740
Frontiers in oncology 2021;11:695740
CDC20 promotes bone formation via APC/C dependent ubiquitination and degradation of p65.
Du Y, Zhang M, Liu X, Li Z, Hu M, Tian Y, Lv L, Zhang X, Liu Y, Zhang P, Zhou Y
EMBO reports 2021 Sep 6;22(9):e52576
EMBO reports 2021 Sep 6;22(9):e52576
Proteasome inhibition by bortezomib parallels a reduction in head and neck cancer cells growth, and an increase in tumor-infiltrating immune cells.
Benvenuto M, Ciuffa S, Focaccetti C, Sbardella D, Fazi S, Scimeca M, Tundo GR, Barillari G, Segni M, Bonanno E, Manzari V, Modesti A, Masuelli L, Coletta M, Bei R
Scientific reports 2021 Sep 24;11(1):19051
Scientific reports 2021 Sep 24;11(1):19051
Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex.
Li XJ, Zhang YY, Fu YH, Zhang H, Li HX, Li QF, Li HL, Tan RK, Jiang CX, Jiang W, Li ZX, Luo C, Lu BX, Dang YJ
Acta pharmacologica Sinica 2021 Oct;42(10):1556-1566
Acta pharmacologica Sinica 2021 Oct;42(10):1556-1566
Hydrogen sulphide reduced the accumulation of lipid droplets in cardiac tissues of db/db mice via Hrd1 S-sulfhydration.
Sun Y, Zhang L, Lu B, Wen J, Wang M, Zhang S, Li Q, Shu F, Lu F, Liu N, Peng S, Zhao Y, Dong S, Lu F, Zhang W, Wang Y
Journal of cellular and molecular medicine 2021 Oct;25(19):9154-9167
Journal of cellular and molecular medicine 2021 Oct;25(19):9154-9167
Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy: Dynamic analysis on cytotoxic effects of LW-218.
Hu P, Li H, Sun W, Wang H, Yu X, Qing Y, Wang Z, Zhu M, Xu J, Guo Q, Hui H
Acta pharmaceutica Sinica. B 2021 Oct;11(10):3178-3192
Acta pharmaceutica Sinica. B 2021 Oct;11(10):3178-3192
Melatonin potentiates the cytotoxic effect of Neratinib in HER2+ breast cancer through promoting endocytosis and lysosomal degradation of HER2.
Liu Z, Sang X, Wang M, Liu Y, Liu J, Wang X, Liu P, Cheng H
Oncogene 2021 Nov;40(44):6273-6283
Oncogene 2021 Nov;40(44):6273-6283
NudCL2 is an autophagy receptor that mediates selective autophagic degradation of CP110 at mother centrioles to promote ciliogenesis.
Liu M, Zhang W, Li M, Feng J, Kuang W, Chen X, Yang F, Sun Q, Xu Z, Hua J, Yang C, Liu W, Shu Q, Yang Y, Zhou T, Xie S
Cell research 2021 Nov;31(11):1199-1211
Cell research 2021 Nov;31(11):1199-1211
DOC-2/DAB2 interactive protein destabilizes c-Myc to impair the growth and self-renewal of colon tumor-repopulating cells.
Li H, Zhou Y, Wang M, Wang H, Zhang Y, Peng R, Zhang R, Zhang M, Zhang M, Qiu P, Liu L, Zhao Q, Liu J
Cancer science 2021 Nov;112(11):4593-4603
Cancer science 2021 Nov;112(11):4593-4603
Glutathione-responsive copper-disulfiram nanoparticles for enhanced tumor chemotherapy.
Chen M, Huang Z, Xia M, Ding Y, Shan T, Guan Z, Dai X, Xu X, Huang Y, Huang M, Zhao C
Journal of controlled release : official journal of the Controlled Release Society 2021 Nov 29;341:351-363
Journal of controlled release : official journal of the Controlled Release Society 2021 Nov 29;341:351-363
Golgi Phosphoprotein 3 Confers Radioresistance via Stabilizing EGFR in Lung Adenocarcinoma.
Chen G, Kong P, Yang M, Hu W, Prise KM, Yu KN, Cui S, Qin F, Meng G, Almahi WA, Nie L, Han W
International journal of radiation oncology, biology, physics 2021 Nov 26;
International journal of radiation oncology, biology, physics 2021 Nov 26;
Efficacy and long-term safety of CRISPR/Cas9 genome editing in the SOD1-linked mouse models of ALS.
Deng HX, Zhai H, Shi Y, Liu G, Lowry J, Liu B, Ryan ÉB, Yan J, Yang Y, Zhang N, Yang Z, Liu E, Ma YC, Siddique T
Communications biology 2021 Mar 25;4(1):396
Communications biology 2021 Mar 25;4(1):396
Gankyrin activates the hedgehog signalling to drive metastasis in osteosarcoma.
Wang C, Jing J, Hu X, Yu S, Yao F, Li Z, Cheng L
Journal of cellular and molecular medicine 2021 Jun 5;
Journal of cellular and molecular medicine 2021 Jun 5;
Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2/ARE axis.
Liu Z, He Q, Liu Y, Zhang Y, Cui M, Peng H, Wang Y, Chen S, Li D, Chen L, Xiao Y, Chen W, Wang Q
Toxicology 2021 Jun 30;458:152838
Toxicology 2021 Jun 30;458:152838
Osteocrin, a novel myokine, prevents diabetic cardiomyopathy via restoring proteasomal activity.
Zhang X, Hu C, Yuan XP, Yuan YP, Song P, Kong CY, Teng T, Hu M, Xu SC, Ma ZG, Tang QZ
Cell death & disease 2021 Jun 16;12(7):624
Cell death & disease 2021 Jun 16;12(7):624
PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53.
Wang W, Wei J, Zhang H, Zheng X, Zhou H, Luo Y, Yang J, Deng Q, Huang S, Fu Z
Cell death & disease 2021 Jun 11;12(6):605
Cell death & disease 2021 Jun 11;12(6):605
Nedd4-2 haploinsufficiency in mice causes increased seizure susceptibility and impaired Kir4.1 ubiquitination.
Liu X, Zhang H, Zhang B, Tu J, Li X, Zhao Y
Biochimica et biophysica acta. Molecular basis of disease 2021 Jun 1;1867(6):166128
Biochimica et biophysica acta. Molecular basis of disease 2021 Jun 1;1867(6):166128
USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites.
Chai P, Cheng Y, Hou C, Yin L, Zhang D, Hu Y, Chen Q, Zheng P, Teng J, Chen J
The Journal of cell biology 2021 Jul 5;220(7)
The Journal of cell biology 2021 Jul 5;220(7)
Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/TfR1 pathway in the rat hearts after ischemia/reperfusion.
Tang LJ, Zhou YJ, Xiong XM, Li NS, Zhang JJ, Luo XJ, Peng J
Free radical biology & medicine 2021 Jan;162:339-352
Free radical biology & medicine 2021 Jan;162:339-352
Baicalein suppresses growth of non-small cell lung carcinoma by targeting MAP4K3.
Li J, Yan L, Luo J, Tong L, Gao Y, Feng W, Wang F, Cui W, Li S, Sun Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:110965
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:110965
Polyglucosan body myopathy 1 may cause cognitive impairment: a case report from China.
Chen L, Wang N, Hu W, Yu X, Yang R, Han Y, Yan Y, Nian N, Sha C
BMC musculoskeletal disorders 2021 Jan 7;22(1):35
BMC musculoskeletal disorders 2021 Jan 7;22(1):35
Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice.
Ding X, Xiang Z, Qin C, Chen Y, Tian H, Meng L, Xia D, Liu H, Song J, Fu J, Ma M, Wang X
Acta neuropathologica communications 2021 Jan 18;9(1):15
Acta neuropathologica communications 2021 Jan 18;9(1):15
FV-429 induces autophagy blockage and lysosome-dependent cell death of T-cell malignancies via lysosomal dysregulation.
Hu P, Wang J, Qing Y, Li H, Sun W, Yu X, Hui H, Guo Q, Xu J
Cell death & disease 2021 Jan 13;12(1):80
Cell death & disease 2021 Jan 13;12(1):80
Dysregulation of USP18/FTO/PYCR1 signaling network promotes bladder cancer development and progression.
Song W, Yang K, Luo J, Gao Z, Gao Y
Aging 2021 Jan 10;13(3):3909-3925
Aging 2021 Jan 10;13(3):3909-3925
Role of the E3 ubiquitin ligase HRD1 in the regulation of serotonin transporter function.
Taguchi K, Kaneko M, Motoike S, Harada K, Hide I, Tanaka S, Sakai N
Biochemical and biophysical research communications 2021 Jan 1;534:583-589
Biochemical and biophysical research communications 2021 Jan 1;534:583-589
FAT10 promotes the progression of bladder cancer by upregulating HK2 through the EGFR/AKT pathway.
Zou Y, Du Y, Cheng C, Deng X, Shi Z, Lu X, Hu H, Qiu J, Jiang W
Experimental cell research 2021 Jan 1;398(1):112401
Experimental cell research 2021 Jan 1;398(1):112401
SQSTM1/ p62 oligomerization contributes to Aβ-induced inhibition of Nrf2 signaling.
Guo C, Zhang Y, Nie Q, Cao D, Wang X, Wan X, Liu M, Cui J, Sun J, Bai Y, Li L
Neurobiology of aging 2021 Feb;98:10-20
Neurobiology of aging 2021 Feb;98:10-20
The novel ZEB1-upregulated protein PRTG induced by Helicobacter pylori infection promotes gastric carcinogenesis through the cGMP/PKG signaling pathway.
Xiang T, Yuan C, Guo X, Wang H, Cai Q, Xiang Y, Luo W, Liu G
Cell death & disease 2021 Feb 4;12(2):150
Cell death & disease 2021 Feb 4;12(2):150
DUOX2 promotes the progression of colorectal cancer cells by regulating the AKT pathway and interacting with RPL3.
Zhang X, Han J, Feng L, Zhi L, Jiang D, Yu B, Zhang Z, Gao B, Zhang C, Li M, Zhao L, Wang G
Carcinogenesis 2021 Feb 11;42(1):105-117
Carcinogenesis 2021 Feb 11;42(1):105-117
Upstream open reading frame with NOTCH2NLC GGC expansion generates polyglycine aggregates and disrupts nucleocytoplasmic transport: implications for polyglycine diseases.
Zhong S, Lian Y, Luo W, Luo R, Wu X, Ji J, Ji Y, Ding J, Wang X
Acta neuropathologica 2021 Dec;142(6):1003-1023
Acta neuropathologica 2021 Dec;142(6):1003-1023
Hsa_circ_0024093 accelerates VSMC proliferation via miR-4677-3p/miR-889-3p/USP9X/YAP1 axis in in vitro model of lower extremity ASO.
Zhang X, Wang P, Yuan K, Li M, Shen Y, Que H, Wang Y, Liang W
Molecular therapy. Nucleic acids 2021 Dec 3;26:511-522
Molecular therapy. Nucleic acids 2021 Dec 3;26:511-522
SPOCK1 promotes metastasis in pancreatic cancer via NF-κB-dependent epithelial-mesenchymal transition by interacting with IκB-α.
Cui X, Wang Y, Lan W, Wang S, Cui Y, Zhang X, Lin Z, Piao J
Cellular oncology (Dordrecht) 2021 Dec 2;
Cellular oncology (Dordrecht) 2021 Dec 2;
Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling.
Cao P, Yang A, Li P, Xia X, Han Y, Zhou G, Wang R, Yang F, Li Y, Zhang Y, Cui Y, Ji H, Lu L, He F, Zhou G
Science advances 2021 Aug;7(35)
Science advances 2021 Aug;7(35)
Increased AT1 receptor expression mediates vasoconstriction leading to hypertension in Snx1-/- mice.
Liu C, Li X, Fu J, Chen K, Liao Q, Wang J, Chen C, Luo H, Jose PA, Yang Y, Yang J, Zeng C
Hypertension research : official journal of the Japanese Society of Hypertension 2021 Aug;44(8):906-917
Hypertension research : official journal of the Japanese Society of Hypertension 2021 Aug;44(8):906-917
Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage.
Dai C, Wu B, Chen Y, Li X, Bai Y, Du Y, Pang Y, Wang YT, Dong Z
Cell death and differentiation 2021 Aug;28(8):2367-2384
Cell death and differentiation 2021 Aug;28(8):2367-2384
Ubiquitin-dependent Argonauteprotein MEL1 degradation is essential for rice sporogenesis and phasiRNA target regulation.
Lian JP, Yang YW, He RR, Yang L, Zhou YF, Lei MQ, Zhang Z, Huang JH, Cheng Y, Liu YW, Zhang YC, Chen YQ
The Plant cell 2021 Aug 31;33(8):2685-2700
The Plant cell 2021 Aug 31;33(8):2685-2700
Anaplasma phagocytophilum AptA enhances the UPS, autophagy, and anti-apoptosis of host cells by PSMG3.
Ma Z, Li R, Hu R, Zheng W, Yu S, Cheng K, Zhang H, Xiao Y, Yi J, Wang Z, Wang Y, Chen C
International journal of biological macromolecules 2021 Aug 1;184:497-508
International journal of biological macromolecules 2021 Aug 1;184:497-508
Anti-tumor activity of a novel proteasome inhibitor D395 against multiple myeloma and its lower cardiotoxicity compared with carfilzomib.
Shen X, Wu C, Lei M, Yan Q, Zhang H, Zhang L, Wang X, Yang Y, Li J, Zhu Y, Chen L
Cell death & disease 2021 Apr 30;12(5):429
Cell death & disease 2021 Apr 30;12(5):429
FBXL10 promotes ERRα protein stability and proliferation of breast cancer cells by enhancing the mono-ubiquitylation of ERRα.
Yang Y, Li S, Li B, Li Y, Xia K, Aman S, Yang Y, Ahmad B, Zhao B, Wu H
Cancer letters 2021 Apr 1;502:108-119
Cancer letters 2021 Apr 1;502:108-119
Cancer Cell enters reversible quiescence through Intracellular Acidification to resist Paclitaxel Cytotoxicity.
Jia M, Zheng D, Wang X, Zhang Y, Chen S, Cai X, Mo L, Hu Z, Li H, Zhou Z, Li J
International journal of medical sciences 2020;17(11):1652-1664
International journal of medical sciences 2020;17(11):1652-1664
Parkin interacts with Mitofilin to increase dopaminergic neuron death in response to Parkinson's disease-related stressors.
Imam Aliagan AD, Ahwazi MD, Tombo N, Feng Y, Bopassa JC
American journal of translational research 2020;12(11):7542-7564
American journal of translational research 2020;12(11):7542-7564
HDAC6, A Novel Cargo for Autophagic Clearance of Stress Granules, Mediates the Repression of the Type I Interferon Response During Coxsackievirus A16 Infection.
Zheng Y, Zhu G, Tang Y, Yan J, Han S, Yin J, Peng B, He X, Liu W
Frontiers in microbiology 2020;11:78
Frontiers in microbiology 2020;11:78
Ubiquitin E3 Ligase c-Cbl Is a Host Negative Regulator of Nef Protein of HIV-1.
Zhang HG, Guo J, Yuan Y, Zuo Y, Liu J, Zhu L, Miao Y, Chen X, Jin L, Huang F, Ren T, He J, Shi W, Wen Z, Zhu C, Zheng H, Dong C, Qian F
Frontiers in microbiology 2020;11:597972
Frontiers in microbiology 2020;11:597972
SPOP attenuates migration and invasion of choriocarcinoma cells by promoting DHX9 degradation.
Yuan D, Chen Y, Yang Z, Li G, Wu M, Jiang J, Li D, Yu Q
American journal of cancer research 2020;10(8):2428-2445
American journal of cancer research 2020;10(8):2428-2445
WDHD1 Leads to Cisplatin Resistance by Promoting MAPRE2 Ubiquitination in Lung Adenocarcinoma.
Gong L, Xiao M, He D, Hu Y, Zhu Y, Xiang L, Bao Y, Liu X, Zeng Q, Liu J, Zhou M, Zhou Y, Cheng Y, Zhang Y, Deng L, Zhu R, Lan H, Cao K
Frontiers in oncology 2020;10:461
Frontiers in oncology 2020;10:461
p53 Affects PGC1α Stability Through AKT/GSK-3β to Enhance Cisplatin Sensitivity in Non-Small Cell Lung Cancer.
Deng X, Li Y, Gu S, Chen Y, Yu B, Su J, Sun L, Liu Y
Frontiers in oncology 2020;10:1252
Frontiers in oncology 2020;10:1252
Tobramycin suppresses HUWE1 degradation to control MCL-1 stability during tumour development.
He J, Wu S, Li X, Tang L, Chen H, Qin L, Xie J, Lu T, Xu W
Clinical and experimental pharmacology & physiology 2020 Sep;47(9):1600-1610
Clinical and experimental pharmacology & physiology 2020 Sep;47(9):1600-1610
Crosstalk between cardiomyocytes and noncardiomyocytes is essential to prevent cardiomyocyte apoptosis induced by proteasome inhibition.
Guo F, Zhang CC, Yin XH, Li T, Fang CH, He XB
Cell death & disease 2020 Sep 19;11(9):783
Cell death & disease 2020 Sep 19;11(9):783
The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models.
Wu H, Sun H, He Z, Chen X, Li Y, Zhao X, Kong W, Kong W
Experimental cell research 2020 Sep 1;394(1):112093
Experimental cell research 2020 Sep 1;394(1):112093
Involvement of p53 Acetylation in Growth Suppression of Cutaneous T-Cell Lymphomas Induced by HDAC Inhibition.
Yu X, Li H, Zhu M, Hu P, Liu X, Qing Y, Wang X, Wang H, Wang Z, Xu J, Tan R, Guo Q, Hui H
The Journal of investigative dermatology 2020 Oct;140(10):2009-2022.e4
The Journal of investigative dermatology 2020 Oct;140(10):2009-2022.e4
LINC00452 promotes ovarian carcinogenesis through increasing ROCK1 by sponging miR-501-3p and suppressing ubiquitin-mediated degradation.
Yang J, Wang WG, Zhang KQ
Aging 2020 Nov 9;12(21):21129-21146
Aging 2020 Nov 9;12(21):21129-21146
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis.
Li ST, Huang, Shen S, Cai Y, Xing S, Wu G, Jiang Z, Hao Y, Yuan M, Wang N, Zhu L, Yan R, Yang D, Wang L, Liu Z, Hu X, Zhou R, Qu K, Li A, Duan X, Zhang H, Gao P
Nature metabolism 2020 Mar;2(3):256-269
Nature metabolism 2020 Mar;2(3):256-269
SUMOylation Protects FASN Against Proteasomal Degradation in Breast Cancer Cells Treated with Grape Leaf Extract.
Floris A, Mazarei M, Yang X, Robinson AE, Zhou J, Barberis A, D'hallewin G, Azara E, Spissu Y, Iglesias-Ara A, Orrù S, Tomasi ML
Biomolecules 2020 Mar 31;10(4)
Biomolecules 2020 Mar 31;10(4)
α-synuclein strains that cause distinct pathologies differentially inhibit proteasome.
Suzuki G, Imura S, Hosokawa M, Katsumata R, Nonaka T, Hisanaga SI, Saeki Y, Hasegawa M
eLife 2020 Jul 22;9
eLife 2020 Jul 22;9
Arabidopsis SINAT Proteins Control Autophagy by Mediating Ubiquitylation and Degradation of ATG13.
Qi H, Li J, Xia FN, Chen JY, Lei X, Han MQ, Xie LJ, Zhou QM, Xiao S
The Plant cell 2020 Jan;32(1):263-284
The Plant cell 2020 Jan;32(1):263-284
Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages.
He X, Chen S, Li C, Ban J, Wei Y, He Y, Liu F, Chen Y, Chen J
Cells 2020 Jan 4;9(1)
Cells 2020 Jan 4;9(1)
A robust TDP-43 knock-in mouse model of ALS.
Huang SL, Wu LS, Lee M, Chang CW, Cheng WC, Fang YS, Chen YR, Cheng PL, Shen CJ
Acta neuropathologica communications 2020 Jan 21;8(1):3
Acta neuropathologica communications 2020 Jan 21;8(1):3
Voltage-gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation.
Li S, Han J, Guo G, Sun Y, Zhang T, Zhao M, Xu Y, Cui Y, Liu Y, Zhang J
FEBS letters 2020 Feb;594(3):497-508
FEBS letters 2020 Feb;594(3):497-508
Lanosterol modulates proteostasis via dissolving cytosolic sequestosomes/aggresome-like induced structures.
Hu LD, Wang J, Chen XJ, Yan YB
Biochimica et biophysica acta. Molecular cell research 2020 Feb;1867(2):118617
Biochimica et biophysica acta. Molecular cell research 2020 Feb;1867(2):118617
Hydrogen sulfide regulates muscle RING finger-1 protein S-sulfhydration at Cys(44) to prevent cardiac structural damage in diabetic cardiomyopathy.
Sun X, Zhao D, Lu F, Peng S, Yu M, Liu N, Sun Y, Du H, Wang B, Chen J, Dong S, Lu F, Zhang W
British journal of pharmacology 2020 Feb;177(4):836-856
British journal of pharmacology 2020 Feb;177(4):836-856
Down-Regulated CUEDC2 Increases GDNF Expression by Stabilizing CREB Through Reducing Its Ubiquitination in Glioma.
Liu XF, Tang CX, Zhang L, Tong SY, Wang Y, Abdulrahman AA, Ji GQ, Gao Y, Gao DS, Zhang BL
Neurochemical research 2020 Dec;45(12):2915-2925
Neurochemical research 2020 Dec;45(12):2915-2925
MAFG-AS1 promotes tumor progression via regulation of the HuR/PTBP1 axis in bladder urothelial carcinoma.
Xiao M, Liu J, Xiang L, Zhao K, He D, Zeng Q, Zhang Q, Xie D, Deng M, Zhu Y, Zhang Y, Liu Y, Bo H, Liu X, Chen X, Gong L, Bao Y, Hu Y, Cheng Y, Deng L, Zhu R, Xing X, Zhou M, Xiong W, Zhou Y, Zhou J, Li X, Cao K
Clinical and translational medicine 2020 Dec;10(8):e241
Clinical and translational medicine 2020 Dec;10(8):e241
PHLDA1 promotes microglia-mediated neuroinflammation via regulating K63-linked ubiquitination of TRAF6.
Han C, Yan P, He T, Cheng J, Zheng W, Zheng LT, Zhen X
Brain, behavior, and immunity 2020 Aug;88:640-653
Brain, behavior, and immunity 2020 Aug;88:640-653
Hydrogen sulphide ameliorating skeletal muscle atrophy in db/db mice via Muscle RING finger 1 S-sulfhydration.
Lu F, Lu B, Zhang L, Wen J, Wang M, Zhang S, Li Q, Shu F, Sun Y, Liu N, Peng S, Zhao Y, Dong S, Zhao D, Lu F, Zhang W
Journal of cellular and molecular medicine 2020 Aug;24(16):9362-9377
Journal of cellular and molecular medicine 2020 Aug;24(16):9362-9377
Long non-coding RNA LOC100133669 promotes cell proliferation in oesophageal squamous cell carcinoma.
Guan Z, Wang Y, Wang Y, Liu X, Wang Y, Zhang W, Chi X, Dong Y, Liu X, Shao S, Zhan Q
Cell proliferation 2020 Apr;53(4):e12750
Cell proliferation 2020 Apr;53(4):e12750
Exogenous H2S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.
Sun Y, Lu F, Yu X, Wang B, Chen J, Lu F, Peng S, Sun X, Yu M, Chen H, Wang Y, Zhang L, Liu N, Du H, Zhao D, Zhang W
Aging and disease 2020 Apr;11(2):269-285
Aging and disease 2020 Apr;11(2):269-285
Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6/TAK1/MAPK and Nrf2 Signaling Pathway.
Liao HH, Zhang N, Meng YY, Feng H, Yang JJ, Li WJ, Chen S, Wu HM, Deng W, Tang QZ
Oxidative medicine and cellular longevity 2019;2019:6304058
Oxidative medicine and cellular longevity 2019;2019:6304058
The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein.
Wu L, Lin Y, Feng J, Qi Y, Wang X, Lin Q, Shi W, Zheng E, Wang W, Hou Z, Lin H, Yu C, He Y, Xu Y, Yang H, Lin L, Li L
Cancer cell international 2019;19:222
Cancer cell international 2019;19:222
STAT3 Regulates the Type I IFN-Mediated Antiviral Response by Interfering with the Nuclear Entry of STAT1.
Wang H, Yuan M, Wang S, Zhang L, Zhang R, Zou X, Wang X, Chen D, Wu Z
International journal of molecular sciences 2019 Sep 30;20(19)
International journal of molecular sciences 2019 Sep 30;20(19)
Long Noncoding RNA-DACH1 (Dachshund Homolog 1) Regulates Cardiac Function by Inhibiting SERCA2a (Sarcoplasmic Reticulum Calcium ATPase 2a).
Cai B, Zhang Y, Zhao Y, Wang J, Li T, Zhang Y, Jiang Y, Jin X, Xue G, Li P, Sun Y, Huang Q, Zhang X, Su W, Yang Y, Sun Y, Shi L, Li X, Lu Y, Yang B, Pan Z
Hypertension (Dallas, Tex. : 1979) 2019 Oct;74(4):833-842
Hypertension (Dallas, Tex. : 1979) 2019 Oct;74(4):833-842
Cinobufotalin powerfully reversed EBV-miR-BART22-induced cisplatin resistance via stimulating MAP2K4 to antagonize non-muscle myosin heavy chain IIA/glycogen synthase 3β/β-catenin signaling pathway.
Liu Y, Jiang Q, Liu X, Lin X, Tang Z, Liu C, Zhou J, Zhao M, Li X, Cheng Z, Li L, Xie Y, Liu Z, Fang W
EBioMedicine 2019 Oct;48:386-404
EBioMedicine 2019 Oct;48:386-404
Autophagy protects HUVECs against ER stress-mediated apoptosis under simulated microgravity.
Li CF, Pan YK, Gao Y, Shi F, Wang YC, Sun XQ
Apoptosis : an international journal on programmed cell death 2019 Oct;24(9-10):812-825
Apoptosis : an international journal on programmed cell death 2019 Oct;24(9-10):812-825
The immunoproteasome catalytic β5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation.
Xie X, Bi HL, Lai S, Zhang YL, Li N, Cao HJ, Han L, Wang HX, Li HH
Science advances 2019 May;5(5):eaau0495
Science advances 2019 May;5(5):eaau0495
Nilotinib: A Tyrosine Kinase Inhibitor Mediates Resistance to Intracellular Mycobacterium Via Regulating Autophagy.
Hussain T, Zhao D, Shah SZA, Sabir N, Wang J, Liao Y, Song Y, Dong H, Hussain Mangi M, Ni J, Yang L, Zhou X
Cells 2019 May 26;8(5)
Cells 2019 May 26;8(5)
The endogenous retrovirus-derived long noncoding RNA TROJAN promotes triple-negative breast cancer progression via ZMYND8 degradation.
Jin X, Xu XE, Jiang YZ, Liu YR, Sun W, Guo YJ, Ren YX, Zuo WJ, Hu X, Huang SL, Shen HJ, Lan F, He YF, Hu GH, Di GH, He XH, Li DQ, Liu S, Yu KD, Shao ZM
Science advances 2019 Mar;5(3):eaat9820
Science advances 2019 Mar;5(3):eaat9820
THZ1 suppresses human non-small-cell lung cancer cells in vitro through interference with cancer metabolism.
Cheng ZJ, Miao DL, Su QY, Tang XL, Wang XL, Deng LB, Shi HD, Xin HB
Acta pharmacologica Sinica 2019 Jun;40(6):814-822
Acta pharmacologica Sinica 2019 Jun;40(6):814-822
Fludarabine as an Adjuvant Improves Newcastle Disease Virus-Mediated Antitumor Immunity in Hepatocellular Carcinoma.
Meng G, Fei Z, Fang M, Li B, Chen A, Xu C, Xia M, Yu D, Wei J
Molecular therapy oncolytics 2019 Jun 28;13:22-34
Molecular therapy oncolytics 2019 Jun 28;13:22-34
Autosomal dominant mitochondrial membrane protein-associated neurodegeneration (MPAN).
Gregory A, Lotia M, Jeong SY, Fox R, Zhen D, Sanford L, Hamada J, Jahic A, Beetz C, Freed A, Kurian MA, Cullup T, van der Weijden MCM, Nguyen V, Setthavongsack N, Garcia D, Krajbich V, Pham T, Woltjer R, George BP, Minks KQ, Paciorkowski AR, Hogarth P, Jankovic J, Hayflick SJ
Molecular genetics & genomic medicine 2019 Jul;7(7):e00736
Molecular genetics & genomic medicine 2019 Jul;7(7):e00736
Hsp90ab1 stabilizes LRP5 to promote epithelial-mesenchymal transition via activating of AKT and Wnt/β-catenin signaling pathways in gastric cancer progression.
Wang H, Deng G, Ai M, Xu Z, Mou T, Yu J, Liu H, Wang S, Li G
Oncogene 2019 Feb;38(9):1489-1507
Oncogene 2019 Feb;38(9):1489-1507
YY1-regulated LINC00152 promotes triple negative breast cancer progression by affecting on stability of PTEN protein.
Shen X, Zhong J, Yu P, Zhao Q, Huang T
Biochemical and biophysical research communications 2019 Feb 5;509(2):448-454
Biochemical and biophysical research communications 2019 Feb 5;509(2):448-454
Kindlin-2 links mechano-environment to proline synthesis and tumor growth.
Guo L, Cui C, Zhang K, Wang J, Wang Y, Lu Y, Chen K, Yuan J, Xiao G, Tang B, Sun Y, Wu C
Nature communications 2019 Feb 19;10(1):845
Nature communications 2019 Feb 19;10(1):845
USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication.
Pan T, Song Z, Wu L, Liu G, Ma X, Peng Z, Zhou M, Liang L, Liu B, Liu J, Zhang J, Zhang X, Huang R, Zhao J, Li Y, Ling X, Luo Y, Tang X, Cai W, Deng K, Li L, Zhang H
eLife 2019 Aug 9;8
eLife 2019 Aug 9;8
Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy.
Cai Q, Wang S, Jin L, Weng M, Zhou D, Wang J, Tang Z, Quan Z
Molecular cancer 2019 Apr 5;18(1):82
Molecular cancer 2019 Apr 5;18(1):82
Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice.
Duan W, Guo M, Yi L, Zhang J, Bi Y, Liu Y, Li Y, Li Z, Ma Y, Zhang G, Liu Y, Song X, Li C
Aging 2019 Apr 30;11(8):2457-2476
Aging 2019 Apr 30;11(8):2457-2476
TRIM59 regulates autophagy through modulating both the transcription and the ubiquitination of BECN1.
Han T, Guo M, Gan M, Yu B, Tian X, Wang JB
Autophagy 2018;14(12):2035-2048
Autophagy 2018;14(12):2035-2048
M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole.
Huang N, Zhang D, Li F, Chai P, Wang S, Teng J, Chen J
Nature communications 2018 Oct 30;9(1):4511
Nature communications 2018 Oct 30;9(1):4511
Pyk2 deficiency potentiates osteoblast differentiation and mineralizing activity in response to estrogen or raloxifene.
Posritong S, Hong JM, Eleniste PP, McIntyre PW, Wu JL, Himes ER, Patel V, Kacena MA, Bruzzaniti A
Molecular and cellular endocrinology 2018 Oct 15;474:35-47
Molecular and cellular endocrinology 2018 Oct 15;474:35-47
14-3-3ζ binds to hepatitis B virus protein X and maintains its protein stability in hepatocellular carcinoma cells.
Tang Y, Zhang Y, Wang C, Sun Z, Li L, Dong J, Zhou W
Cancer medicine 2018 Nov;7(11):5543-5553
Cancer medicine 2018 Nov;7(11):5543-5553
Downregulation of glycine decarboxylase enhanced cofilin-mediated migration in hepatocellular carcinoma cells.
Zhuang H, Li Q, Zhang X, Ma X, Wang Z, Liu Y, Yi X, Chen R, Han F, Zhang N, Li Y
Free radical biology & medicine 2018 May 20;120:1-12
Free radical biology & medicine 2018 May 20;120:1-12
Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation.
Guo XB, Deng X, Wei Y
Stem cells (Dayton, Ohio) 2018 Mar;36(3):406-419
Stem cells (Dayton, Ohio) 2018 Mar;36(3):406-419
Identification of Residues Controlling Restriction versus Enhancing Activities of IFITM Proteins on Entry of Human Coronaviruses.
Zhao X, Sehgal M, Hou Z, Cheng J, Shu S, Wu S, Guo F, Le Marchand SJ, Lin H, Chang J, Guo JT
Journal of virology 2018 Mar 15;92(6)
Journal of virology 2018 Mar 15;92(6)
CRISPR/Cas9-Targeted Deletion of Polyglutamine in Spinocerebellar Ataxia Type 3-Derived Induced Pluripotent Stem Cells.
Ouyang S, Xie Y, Xiong Z, Yang Y, Xian Y, Ou Z, Song B, Chen Y, Xie Y, Li H, Sun X
Stem cells and development 2018 Jun 1;27(11):756-770
Stem cells and development 2018 Jun 1;27(11):756-770
Ubiquitin-Specific Protease USP6 Regulates the Stability of the c-Jun Protein.
Li L, Yang H, He Y, Li T, Feng J, Chen W, Ao L, Shi X, Lin Y, Liu H, Zheng E, Lin Q, Bu J, Zeng Y, Zheng M, Xu Y, Liao Z, Lin J, Lin D
Molecular and cellular biology 2018 Jan 15;38(2)
Molecular and cellular biology 2018 Jan 15;38(2)
SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer.
Xiong Y, Wang L, Wang S, Wang M, Zhao J, Zhang Z, Li X, Jia L, Han Y
Journal of cancer research and clinical oncology 2018 Feb;144(2):189-198
Journal of cancer research and clinical oncology 2018 Feb;144(2):189-198
The N-terminal ubiquitin-associated domain of Cezanne is crucial for its function to suppress NF-κB pathway.
Ji Y, Cao L, Zeng L, Zhang Z, Xiao Q, Guan P, Chen S, Chen Y, Wang M, Guo D
Journal of cellular biochemistry 2018 Feb;119(2):1979-1991
Journal of cellular biochemistry 2018 Feb;119(2):1979-1991
Temozolomide-perillyl alcohol conjugate downregulates O6-methylguanin DNA methltransferase via inducing ubiquitination-dependent proteolysis in non-small cell lung cancer.
Song X, Xie L, Chang M, Geng X, Wang X, Chen TC, Song X
Cell death & disease 2018 Feb 9;9(2):202
Cell death & disease 2018 Feb 9;9(2):202
The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma.
Li Z, Zhang J, Liu X, Li S, Wang Q, Di Chen, Hu Z, Yu T, Ding J, Li J, Yao M, Fan J, Huang S, Gao Q, Zhao Y, He X
Nature communications 2018 Apr 20;9(1):1572
Nature communications 2018 Apr 20;9(1):1572
Role of the Ubiquitin C-Terminal Hydrolase L1-Modulated Ubiquitin Proteasome System in Auditory Cortex Senescence.
Zhang Y, Huang X, Zhao XY, Hu YJ, Sun HY, Kong WJ
ORL; journal for oto-rhino-laryngology and its related specialties 2017;79(3):153-163
ORL; journal for oto-rhino-laryngology and its related specialties 2017;79(3):153-163
Endoplasmic Reticulum Stress Is Involved in Cochlear Cell Apoptosis in a Cisplatin-Induced Ototoxicity Rat Model.
Zong S, Liu T, Wan F, Chen P, Luo P, Xiao H
Audiology & neuro-otology 2017;22(3):160-168
Audiology & neuro-otology 2017;22(3):160-168
HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway.
Deng X, Song L, Zhao W, Wei Y, Guo XB
Frontiers in cellular neuroscience 2017;11:420
Frontiers in cellular neuroscience 2017;11:420
MDM2 Contributes to High Glucose-Induced Glomerular Mesangial Cell Proliferation and Extracellular Matrix Accumulation via Notch1.
Lei CT, Tang H, Ye C, You CQ, Zhang J, Zhang CY, Xiong W, Su H, Zhang C
Scientific reports 2017 Sep 4;7(1):10393
Scientific reports 2017 Sep 4;7(1):10393
Liposomal honokiol induced lysosomal degradation of Hsp90 client proteins and protective autophagy in both gefitinib-sensitive and gefitinib-resistant NSCLC cells.
Yang J, Wu W, Wen J, Ye H, Luo H, Bai P, Tang M, Wang F, Zheng L, Yang S, Li W, Peng A, Yang L, Wan L, Chen L
Biomaterials 2017 Oct;141:188-198
Biomaterials 2017 Oct;141:188-198
Exogenous H2S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.
Wu J, Tian Z, Sun Y, Lu C, Liu N, Gao Z, Zhang L, Dong S, Yang F, Zhong X, Xu C, Lu F, Zhang W
Cell death & disease 2017 Aug 10;8(8):e2992
Cell death & disease 2017 Aug 10;8(8):e2992
AMPK Serves as a Therapeutic Target Against Anemia of Inflammation.
Wang M, Xin H, Tang W, Li Y, Zhang Z, Fan L, Miao L, Tan B, Wang X, Zhu YZ
Antioxidants & redox signaling 2017 Aug 10;27(5):251-268
Antioxidants & redox signaling 2017 Aug 10;27(5):251-268
A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer.
Wu YH, Hong CW, Wang YC, Huang WJ, Yeh YL, Wang BJ, Wang YJ, Chiu HW
Cancer letters 2017 Aug 1;400:79-88
Cancer letters 2017 Aug 1;400:79-88
TRAF Family Proteins Regulate Autophagy Dynamics by Modulating AUTOPHAGY PROTEIN6 Stability in Arabidopsis.
Qi H, Xia FN, Xie LJ, Yu LJ, Chen QF, Zhuang XH, Wang Q, Li F, Jiang L, Xie Q, Xiao S
The Plant cell 2017 Apr;29(4):890-911
The Plant cell 2017 Apr;29(4):890-911
A novel glutaminase inhibitor-968 inhibits the migration and proliferation of non-small cell lung cancer cells by targeting EGFR/ERK signaling pathway.
Han T, Guo M, Zhang T, Gan M, Xie C, Wang JB
Oncotarget 2017 Apr 25;8(17):28063-28073
Oncotarget 2017 Apr 25;8(17):28063-28073
The N-Terminal of Aquareovirus NS80 Is Required for Interacting with Viral Proteins and Viral Replication.
Zhang J, Guo H, Chen Q, Zhang F, Fang Q
PloS one 2016;11(2):e0148550
PloS one 2016;11(2):e0148550
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness.
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 10201-2-AP( ubiquitin Antibody) at dilution of 1:600
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human ovary tumor using 10201-2-AP(ubiquitin antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ubiquitin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ubiquitin. This antibody recognizes human,mouse,rat antigen. The ubiquitin antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
