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- References [871]
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- Product number
- 10201-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10201-2-AP, RRID:AB_671515
- Product name
- ubiquitin antibody
- Antibody type
- Polyclonal
- Description
- ubiquitin antibody (Cat. #10201-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Curcumol Induces Necroptosis of Hepatic Stellate Cells by Targeting KAT8 to Suppress HK2 Lactylation and Promote HUWE1-Dependent Ubiquitination.
NEDD4 promotes reactive astrogliosis by enhancing K63-linked ubiquitination and inhibiting chaperone-mediated autophagy degradation of YAP1.
Potential Anti-Cancer Drug 6RK73 Suppresses Ovarian Cancer Growth by Inactivating the AKT1/Sp1 Induced c-Myc Signaling Pathway.
Curcumin enhances GSDME-mediated pyroptosis to potentiate PD-1/PD-L1 immune checkpoint blockade in colorectal cancer.
PLK1 stabilizes β-catenin to drive colorectal carcinogenesis through NFKB2-mediated transcriptional activation of USP2a and site-specific phosphorylation.
BPGM as an intrinsic brake to constrain metastasis through phospho-epigenetic-mediated carnitine biosynthesis suppression.
RNF220 mediates K63-linked polyubiquitination of STAT3 and aggravates pathological cardiac hypertrophy.
SIRT3 promotes oxaliplatin sensitivity in hepatocellular carcinoma by promoting ferroptosis through endoplasmic reticulum stress response.
USP18 mediates high glucose-induced cardiomyocyte injury by regulating the JAK/STAT signaling pathway through stabilizing FOXC2 expression.
Curcumin augments mitophagy via Nrf2-PINK1-mediated, Parkin-dependent ubiquitination to suppress ferroptosis in post-cardiac arrest brain injury.
NUP62 promotes breast cancer progression and inhibits ferroptosis by stabilizing NRF2 in a KEAP1-dependent way.
Phenylephrine attenuates LPS-induced lung injury via Foxh1/GSK-3β/β-catenin-mediated alveolar epithelial cell differentiation in ARDS.
TRIM24-mediated K27-linked ubiquitination of ULK1 alleviates energy stress-induced autophagy and promote prostate cancer growth in the context of SPOP mutation.
Hypoxia-inducible factor 1αa regulates lipid metabolism to coordinate adipocyte hypertrophy and hyperplasia in grass carp.
Restricting intracellular Salmonella proliferation by coordinating p-TBK1 mediated mitophagy and xenophagy.
Inhibition of PGK1 enhances sensitivity to tyrosine kinase inhibitor in T315I-mutant leukemia.
YTHDF3-TRIM2-P53 axis promotes malignant progression in uveal melanoma (UVM).
Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome-Mediated Colitis and Mood Disorder.
CircIQGAP1-CARM1 axis promotes renal cell carcinoma progression through glycolytic reprogramming.
Downregulation of B7-H4 contributes to the synergistic effect of USP2a-targeted/anti-PD-1 combination therapy in EGFR mutant lung cancer.
Design and Synthesis of Pyrrolo[3,4-d]pyrimidine-Based ATR Degraders for Effective Treatment of Colorectal Cancer in Mouse Model.
Stigmasterol upregulates Akt/mTOR/p70S6K signaling through SYVN1 to alleviate osteoporosis in ovariectomized rats.
Cannabidiol attenuates the LPS/D-Galactosamine-induced acute liver injury by inhibiting parkin-mediated ubiquitination of MFN2.
CDH4/UBA1/RBMX axis promotes polycystic ovary syndrome progression through YAP1 activation.
FAM83D facilitates EMT and metastasis of cervical cancer via interaction with GSK3β and inactivation of GSK3β/stabilization of Snail signaling.
USP5-mediated CD73 deubiquitination drives osimertinib resistance via PI3K/AKT and glycolysis activation in LUAD.
UBA1 promotes cardiac hypertrophy by suppressing autophagy via targeting ATG5 for ubiquitination.
Deubiquitination and stabilization of EIF4A3 by OTUB2 contributes to TPI1-mediated glycolysis and TNBC progression.
UBE2M promotes malignant phenotypes of prostate cancer through mediating NAA10 neddylation.
Lipotoxic hepatocyte-derived UBQLN1-enriched small extracellular vesicles activate hepatic stellate cells to promote hepatic fibrosis.
Inhibition of ZBTB7B-mediated ADPGK transcription by NEDD4 impedes glycolysis and progression of lung adenocarcinoma.
Suppression of LRRC41-mediated oncogenicity in hepatocellular carcinoma via USP7-targeted small molecule inhibitors.
Semaglutide ameliorates aortic endothelial cell dysfunction in sarcopenia through the SIRT1/cGAS-STING signaling axis.
Endothelial cells sense temozolomide resistance to facilitate monocyte-derived macrophage infiltration in glioblastoma.
MG53 protects against septic cardiac dysfunction by ubiquitinating ATF2.
HERC4 downregulates KRT19 to promote lung adenocarcinoma, migration, invasion and EMT.
SLC7A5-ERBB2 axis drives olaparib resistance via de novo lipid synthesis in ovarian cancer.
E3 ubiquitin ligase TRIM47 promotes intrahepatic cholangiocarcinoma progression by ubiquitinating fumarate hydratase and modulating macrophage polarization.
Bushen Huoxue formula component β-Estradiol 3-acetate treats osteoarthritis through enhancing the TLR4 ubiquitination.
Erbin destabilization by O-GlcNAcylation promotes 5-FU resistance via homologous recombination activation in colorectal cancer.
PIM1 protects pancreatic ductal cancer cells from glucose deprivation-induced oxidative stress via OXR1 phosphorylation.
CypA Mediates Non-Small Cell Lung Cancer Chemoresistance by Attenuating Ferroptosis via Stabilizing SLC7A11.
REEP1 Accumulation Disrupts ER Integrity and Drives Spinal Motoneuron Degeneration in Distal Hereditary Motor Neuropathy.
USP11-PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA-cGAS-STING Pathway After Intracerebral Hemorrhage.
Type II Alveolar Epithelial Cells Promote Sepsis-Induced Immunosuppression in Alveolar Macrophages via Exosomal lncRNA Rmrp Release.
Targeting VCP with V8 suppresses glioblastoma development via formation of aggregates and disruption of mitophagy flux.
TGF-β1/SMAD signaling downregulates KLF4 expression via direct transcriptional suppression and FAT10-mediated proteasomal degradation in hepatocellular carcinoma.
USP5 inhibition stimulates immunogenic ferroptosis that enhances immunotherapy in diffuse large B-cell lymphoma.
Indirect ubiquitination independent of endogenous ubiquitination machinery for targeted protein degradation.
MYC-driven TRIM27 upregulation promotes prostate cancer progression by enhancing CANX ubiquitination and activating PI3K/AKT signaling.
Intravesical instillation of pirfenidone/polydopamine nanoparticles for managing neurogenic bladder post-spinal cord injury by alleviating bladder inflammation and fibrosis.
MCM8 promotes colorectal cancer progression by competitively inhibiting HRD1-mediated CDC42 ubiquitination and degradation.
The ER membrane protein complex acts as a chaperone to promote the biogenesis of multi-bundle membrane proteins.
Upregulated ARMCX1 suppresses nasopharyngeal carcinoma progression by promoting TRIM21-mediated β-catenin degradation.
ASF1B promotes gastric cancer liver metastasis through inhibiting ZDHHC9/PCBP1/ SLC7A11 signaling axis mediated ferroptosis.
G3BP2 facilitates abnormal activation of fibroblast-like synoviocytes through p53 signaling pathway in rheumatoid arthritis.
LAMA4, regulated by the transcription factor SP1 or the ubiquitin ligase NEDD4, mediates HUVEC dysfunction under hypoxia/reoxygenation conditions.
Spatiotemporally controlled ferritin-targeting PROTAC nanoplatform for visualized manipulation of endogenous "Iron pool" in pancreatic cancer therapy.
A novel lncRNA, lncMCL1, modulates neural pyroptosis associated with epilepsy via stabilizing DDX3X.
Activation of mitophagy antagonizes high uric acid-induced hepatic lipid accumulation.
Progressive rod bipolar cell loss, ubiquitin accumulation, and subretinal drusenoid deposits in Cln3Δex7/8 mice: New insights into juvenile neuronal ceroid lipofuscinosis pathogenesis.
Reduced Proteasome Degradation of HSF-1 Shifts Protein Stress Management With Age in Caenorhabditis elegans.
The UBC/SIRT5/DRP1 axis regulates mitochondrial dynamics to alleviate Staphylococcus aureus-induced oxidative stress and senescence in bovine mammary epithelial cells.
CHB-Induced Immune Zonation Chaos Elicited LXRα-mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation.
SREBF2 enhances lipid metabolism and represses anti-tumor immune responses in cervical cancer by increasing ACAT2.
The GFPT2/O-GlcNAcylation/c-Myc axis promotes bladder cancer progression.
PyHAT5 regulates anthocyanin biosynthesis in red-fleshed pear and undergoes ubiquitination and degradation by PyAIP2.
Wogonin derivative V8 enhances bortezomib efficacy in gastric carcinoma by disrupting lysosome-mediated drug resistance.
A peptide immunomodulator activates MST1 to expand and stabilize murine and human regulatory T cells for immune tolerance.
Anti-Protein-Adsorption Nano-Proteolysis Targeting Chimeras as a Potent Platform for Efficient Programmed Cell Death Ligand 1 Degradation.
TIGAR maintains intestinal epithelial regeneration by stabilizing HMGCL and promoting β-catenin β-hydroxybutyrylation in burn-induced sepsis.
CircRNA-TMEM71 Inhibits Human Aortic Smooth Muscle Cell Ferroptosis and Prevents Aortic Dissection Formation Through IGF2BP3-Mediated Stability of FSP1.
KIF20A inhibits TRIM21-dependent ubiquitination of DHX9 to boost SOX2 stability, enhancing OSCC stemness and ferroptosis resistance.
Stabilization of IQGAP1 by the mTORC2 component PRR5 mediates mitogenic LINC01133-to-ERK signaling in triple-negative breast cancer.
USP14-mediated inhibition of CDH11 ubiquitination propels IL-1β-induced chondrocyte injury.
Non-classic deubiquitinase USP13 inhibits bladder cancer metastasis through destabilizing cytoplasmic KDM3A.
Core fucosylation of NCEH1 by FUT8 promotes progression of high-grade serous ovarian cancer by driving tumor-associated macrophage M2 polarization.
Nanomagnetic Hyperthermia Sensitizes Gemcitabine Chemosensitivity in Pancreatic Cancer by Inhibiting HSPB1 to Amplify ACSL4-Mediated Ferroptosis.
CircRNA0052011 modulates DNA damage and repair via FEN1 ubiquitination to mitigate polystyrene nanoplastics-induced genotoxicity in the lung.
A Novel GmSIN1-GmRNF1a-GmCSN5a Module Determines Soybean Salt Tolerance and Yield Under Saline Soil Conditions.
Citrulline Modulates Milk Fat Metabolism via the RTN3-FABP5 Axis in Bovine Mammary Epithelial Cells.
Erianin facilitates pyroptosis in endometrial cancer via targeting m6A reader YTHDF1.
HAO2 inhibits the growth and lipid metabolism of head and neck squamous cell carcinoma by enhancing MYH9 ubiquitination mediated by STUB1 and USP14.
USP10 from Human Umbilical Cord Mesenchymal Stem Cells-Derived Extracellular Vesicles Mediates SCL7A11 Deubiquitination in Epithelial Cells: A Key to Anti-ferroptosis and Anti-fibrosis in Pulmonary Fibrosis.
Targeting WWP1 ameliorates osteoarthritis by suppressing KLF15 ubiquitination to restore mtDNA and mitochondrial function.
18-β-glycyrrhetinic acid facilitates nuclear-mitochondrial communications to alleviate oxidative stress through HMGB1-cGAS-Mul1 axis in tendinopathy.
Pellino1 Exacerbates Diabetic Kidney Disease Through NLRP3 Inflammasome Driven Pyroptosis in Renal Tubular Epithelial Cells.
Pathogenic mechanisms of amyotrophic lateral sclerosis-linked VAPB P56S mutation in the degeneration of corticospinal motor neurons.
TRIM32 promotes neuronal ferroptosis by enhancing K63-linked ubiquitination and subsequent p62-selective autophagic degradation of GPX4.
Heat acclimation mediates cellular protection via HSP70 stabilization of HIF-1α protein in extreme environments.
Integrated Analysis of Single-Cell RNA Sequencing and Machine Learning Reveals a T Cell-Specific PANoptosis Signature Predicting Prognosis and Immunotherapy in Prostate Cancer.
cnnm-5 knockdown improves proteostasis of mutant Huntingtin protein in C. elegans.
Inhibition of HPSE/SDC-2 axis-induced epithelial-mesenchymal transition for treating IC/BPS.
TRIM37-mediated stabilization of PEX5 via monoubiquitination attenuates oxidative stress and demyelination in multiple sclerosis insights from EAE and LPC-induced experimental models.
Over-expressed Phospholamban in Cancer-associated Fibroblasts Is a Driver for CMS4 Subtype Colorectal Cancer Formation.
Elevated Bile Acids Induce Circadian Rhythm Sleep Disorders in Chronic Liver Diseases.
Parishin A ameliorates cognitive decline by promoting PS1 autophagy in Alzheimer's disease.
Farrerol inhibits ferroptosis and protects against LPS-induced acute lung injury by targeting the RUNX1/SLC7A11 axis.
PSMD12 promotes hepatocellular carcinoma progression by stabilizing CDK1.
TFEB promotes Ginkgetin-induced ferroptosis via TRIM25 mediated GPX4 lysosomal degradation in EGFR wide-type lung adenocarcinoma.
PINX1 inhibits proliferation and cisplatin resistance in nasopharyngeal carcinoma by promoting ILF3 ubiquitination.
The status of p53 affects the efficacy of PLK1 inhibitor BI6727 in prostate cancer cells.
Tetrahydrocurcumin targets TRIP13 inhibiting the interaction of TRIP13/USP7/c-FLIP to mediate c-FLIP ubiquitination in triple-negative breast cancer.
Phytosphingosine Alleviates Cigarette Smoke-Induced Bronchial Epithelial Cell Senescence in Chronic Obstructive Pulmonary Disease by Targeting the Free Fatty Acid Receptor 4.
HDAC1/2-mediated deacetylation of KLF9 promotes the malignant progression of nasopharyngeal carcinoma via CDH17.
Interplay mechanism of virus latency-reactivation by human cytomegalovirus UL82 protein with the host core histone H3K27 methyltransferase EZH2 of polycomb repressive complex 2.
Inhibition of USP5 Attenuates Atherosclerosis by Suppressing PDCD4-Mediated Endothelial Dysfunction: Evidence from In Vitro HUVEC and In Vivo Models.
Triflupromazine and tranylcypromine alleviate primary cisplatin resistance in lung adenocarcinoma by promoting LDHA-mediated AMBRA1 ubiquitination.
USP48 protects against myocardial ischemia-reperfusion injury by stabilizing and upregulating CNN1 in type 1 diabetes mice.
ANAPC5 mitigates acute lung injury through regulating macrophage M1/M2 polarization via the EGFR/CD24 axis.
Targeting the IRS1 macromolecular signaling node by Trienomycin a triggers cytoprotective autophagy in pancreatic adenocarcinoma.
Fine particulate matter exacerbates asthma by activating STC2-mediated mitophagy through METTL3/YTHDF2-dependent m6A methylation.
The E3 ubiquitin ligase SCFLAO1 promotes NITRITE REDUCTASE degradation to modulate growth and oilseed production in Brassica napus.
CHD4 drives gastric cancer metastasis via MYH9/GSK3β/β-catenin axis and WNT/EMT pathway activation.
USP5 inhibition enables potential therapy for t(8;21) AML through ubiquitin-mediated AML1-ETO degradation in patient-derived xenografts.
Cancer-associated fibroblast derived CXCL14 drives cisplatin chemoresistance by enhancing nucleotide excision repair in bladder cancer.
METTL3-mediated m6A modification of FUNDC1/IP3R2 pathway facilitates cardiac hypertrophy in obesity hypertension.
ASS1 inhibits liver cancer by promoting CAD ubiquitination and reversing the urea cycle and pyrimidine synthesis imbalance.
Environmental aminomethylphosphonic acid (AMPA) exposure increased the risk of spontaneous abortion through lactate-induced JunB lactylation in trophoblast.
YY1-induced USP43 drives ferroptosis suppression by FASN stabilization and subsequent activation of SLC7A11 in ovarian cancer.
Parkin modulates the hepatocellular carcinoma microenvironment by regulating PD-1/PD-L1 signalling.
USP47 Regulates Excitatory Synaptic Plasticity and Modulates Seizures in Murine Models by Blocking Ubiquitinated AMPAR Degradation.
SUMOylation of ZEB1 Modulates PANoptosis in Burn-Induced Early Acute Kidney Injury.
FATS alleviates ulcerative colitis by inhibiting M1 macrophage polarization and aerobic glycolysis through promoting the ubiquitination-mediated degradation of HIF-1α.
Mouse mesenchymal stem cell-derived exosomal miR-205-5p modulates LPS-induced macrophage polarization and alleviates lung injury by regulating the USP7/FOXM1 axis.
Tumor suppressor FBXO11 drives ubiquitin proteasomal degradation of KIF2C to limit ovarian cancer progression and is transcriptionally repressed by ZNF217.
Fusidic Acid Reverses Chemoresistance in Breast Cancer via Targeting DDX6 to Downregulate GSK-3β/β-Catenin Signaling.
Clathrin light chain 2 is a substrate of ubiquitin ligase ATL5 and negatively regulates seed longevity in Arabidopsis.
Degradation of NLRP3 by selective ROCK2 inhibitor alleviates acute lung injury.
Pupylation-based proximity labeling reveals APC/C-mediated ubiquitination and degradation of PEROXIN11C in soybean abiotic stress responses.
Ubiquitin-specific protease 7 regulates macrophage polarization via pyruvate kinase M2-mediated metabolic reprogramming in severe acute pancreatitis.
The deubiquitination enzyme USP14 promotes the tumourigenesis of gastric cancer by enhancing c-MYC nuclear translocation through deubiquitination of KPNA2.
E3 ubiquitin ligase BTRC inhibits the proliferation and tumor growth of glioma cells through the NFAT5/AQP4 axis.
Nephroprotective mechanism of Kunkui Baoshen decoction in diabetic kidney disease: Targeting the HERC2/NCOA4-mediated autophagy-dependent ferroptosis pathway.
PDLIM4 drives gastric cancer malignant progression and cisplatin resistance by inhibiting HSP70 ubiquitination and degradation via competitive interaction with STUB1.
Albiflorin attenuates post-myocardial infarction cardiac fibrosis through inhibiting the RAS-ERK/MAPK signaling pathway.
TRIM39-mediated deubiquitination upregulates RNF168 to evade autophagy-ferroptosis in triple-negative breast cancer.
Development of an efficient mice model of cancer-associated cardiac cachexia.
Aging-associated ZNF573 methylation regulates RNF19B-PIK3CA ubiquitination to promote prostate cancer.
NMRK2 leads to the depletion of CD8(+)T cells by mediating the enhancement of NAD(+)-SIRT1-CD38 axis in PRCC-TFE3 rRCC.
13-Docosenamide Enhances Oligodendrocyte Precursor Cell Differentiation via USP33-Mediated Deubiquitination of CNR1 in Chronic Cerebral Hypoperfusion.
MiR-126-5p Derived From Bone Marrow Mesenchymal Stem Cell Exosomes Promotes Skeletal Muscle Regeneration by Regulating FBXO32/MyoD Signaling.
Sinapic acid and glabridin synergistically mitigate androgenetic alopecia by modulating ferroptosis through stabilization of β-catenin against ubiquitin-dependent degradation.
Silymarin ameliorates diet-induced gallstone formation by regulating gut microbiota-derived GCDCA to suppress ferroptosis-ROS-NFκB signaling pathway.
Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.
CERKL Reduced PI3P/Autophagy to Promote Pancreatic Cancer.
O-GlcNAcylation of PRDX1 enhances its stability and promotes liver cancer progression via activating LRP6-mediated Wnt signaling.
Role of EZH2 in regulating c-Myc stability through the E3 ubiquitin ligase HUWE1 in heart failure and its mechanisms.
APOL2 Stabilizes Ku80 to Confer NHEJ-Mediated Radioresistance in Gastric Cancer.
NCOA4-dependent ferritinophagy drives perfluorooctanoic acid-triggered renal ferroptosis in chicken embryos.
SUN5 interacts with TRIM28, enhancing IκBα ubiquitination to promote glycolysis in colorectal cancer cells.
Oxidative stress reactivates androgen receptor signaling via USP36 to drive castration resistance in prostate cancer.
Activation of the aryl hydrocarbon receptor relieves acute pancreatitis via the RBX1/HSF1 pathway.
CDC26 facilitates ferroptosis through SLC7A11 degradation and cell cycle arrest.
BRD4 inhibition suppresses histone H4 UFMylation to increase ferroptosis sensitivity through TXNIP.
CNOT7 facilitates radiation resistance in colorectal cancer through TRIM21/XRCC6-mediated non-homologous end joining repair.
INHBA promotes chemoresistance in pancreatic cancer by enhancing CTPS1 stability and mediating pyrimidine metabolism.
PNMA4 enhances anti-RNA virus immunity by promoting RIG-I signaling pathway.
RNF180 suppressed aggressiveness by degrading NOTCH1, TRIM24 and FOXC1, and chemoresistance by degrading ACC1 and ACLY in colorectal cancer.
Poricoic Acid A attenuated TGF-β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells through SPRY2/ERK signaling pathway.
ELK1 inhibition alleviates amyloid pathology and memory decline by promoting the SYVN1-mediated ubiquitination and degradation of PS1 in Alzheimer's disease.
Bacteria escape macrophage-mediated phagocytosis via targeting apurinic/apyrimidinic endonuclease 1 in sepsis.
Dihydroartemisinin requires NR1D1 mediated Rab7 ubiquitination to regulate hepatic stellate cells lipophagy in liver fibrosis.
KIF9 Ameliorates Neuropathology and Cognitive Dysfunction by Promoting Macroautophagy in a Mouse Model of Alzheimer's Disease.
EPIC-1042 alleviates cerebral ischemic/reperfusion injury through TAX1BP1-induced mitophagy.
METTL7B-induced histone lactylation prevents heart failure by ameliorating cardiac remodelling.
The Novel Dual GIP and GLP-1 Receptor Agonist Tirzepatide Attenuates Colon Cancer Development by Regulating Glucose Metabolism.
DAPK3 is Essential for DBP-Induced Autophagy of Mouse Leydig Cells.
SIZ1 SUMOylates and stabilizes WRI1 to safeguard seed filling and fatty acid biosynthesis under high-temperature stress.
HucMSCs-Derived Extracellular Vesicles Deliver RPS27A Protein to Manipulate the MDM2-P53 Axis and Ameliorate Neurological Dysfunction in Parkinson's Disease.
Forsythoside A Alleviates Acute Alcoholic Liver Injury by Binding to TLR4 to Inhibit the Activation of the NF-κB Pathway.
Tspan9 Exacerbates Cardiac Hypertrophy by Impairing Cardiac Autophagy.
LM2I leads to CAD ubiquitination and liver cancer suppression through activation of ASS1.
PICK1 overexpression ameliorates endotoxin-induced acute lung injury by regulating mitochondrial quality control via maintaining Nrf-2 stabilization through activating the PI3K/Akt/GSK-3β pathway and disrupting the E3 ubiquitin ligase adapter β-TrCP.
NAP1L1 degradation by FBXW7 reduces the deubiquitination of HDGF-p62 signaling to stimulate autophagy and induce primary cisplatin chemosensitivity in nasopharyngeal carcinoma.
The novel tRNA-derived fragment, tiRNA-Met, inhibits the malignant progression of triple-negative breast cancer by regulating RANBP3L via a targeted interaction with SNRPA.
USP14 inhibits mitophagy and promotes tumorigenesis and chemosensitivity through deubiquitinating BAG4 in microsatellite instability-high colorectal cancer.
ANXA1 promotes intrahepatic cholangiocarcinoma proliferation and growth by regulating glutamine metabolism through GOT1 stabilization.
Perfluorooctane sulfonate induced ferritinophagy via detyrosinated alpha tubulin-TRIM21-HERC2-regulated NCOA4 degradation in hepatocytes.
Engineered Spirulina platensis for treating rheumatoid arthritis and restoring bone homeostasis.
CPT1A/HIF-1α positive feedback loop induced fatty acid oxidation metabolic pathway contributes to the L-ascorbic acid-driven angiogenesis in breast cancer.
HBV core protein enhances WDR46 stabilization to upregulate NUSAP1 and promote HCC progression.
Noncanonical feedback loop between "RIP3-MLKL" and "4EBP1-eIF4E" promotes neuronal necroptosis.
Down-regulation of Selenoprotein K impairs the proliferation and differentiation of chicken skeletal muscle satellite cells by inhibiting the Nrf2 antioxidant signaling pathway.
The MCM6-c-Myc positive feedback loop mediates bladder cancer progression and cisplatin resistance.
Extracellular Ubiquitin Enhances Autophagy and Inhibits Mitochondrial Apoptosis Pathway to Protect Neurons Against Spinal Cord Ischemic Injury via CXCR4.
Mitochondrial ROS-associated integrated stress response is involved in arsenic-induced blood-testis barrier disruption and protective effect of melatonin.
Renal tubular S100A7a impairs fatty acid oxidation and exacerbates renal fibrosis via both intracellular and extracellular pathway.
Targeting YBX1-m5C mediates RNF115 mRNA circularisation and translation to enhance vulnerability of ferroptosis in hepatocellular carcinoma.
4-Octyl Itaconate Alleviates Myocardial Ischemia-Reperfusion Injury Through Promoting Angiogenesis via ERK Signaling Activation.
HAT1/HDAC2 mediated ACSL4 acetylation confers radiosensitivity by inducing ferroptosis in nasopharyngeal carcinoma.
Neutrophil-derived heparin-binding protein increases endothelial permeability in acute lung injury by promoting TRIM21 and the ubiquitination of P65.
CDC20 protects the heart from doxorubicin-induced cardiotoxicity by modulating CCDC69 degradation.
Lactylation increases the stability of RBM15 to drives m6A modification in non-small-cell lung cancer cells.
Designer polyQ fusion proteins sequester USP7/HDM2 for modulating P53 functionality.
USP8 and Hsp70 regulate endoreplication by synergistically promoting Fzr deubiquitination and stabilization.
TRIM22 inhibits the metastasis of colorectal cancer through facilitating β-Catenin degradation.
A novel mechanism in regulating drug sensitivity, growth, and apoptosis of bortezomib-resistant multiple myeloma cells: the USP4/KLF2/HMGA2 cascade.
YTHDC1 promotes postnatal brown adipose tissue development and thermogenesis by stabilizing PPARγ.
Exosomal miR-196a-5p Secreted by Bone Marrow Mesenchymal Stem Cells Inhibits Ferroptosis and Promotes Drug Resistance of Acute Myeloid Leukemia.
Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression.
Redox regulation of TRIM28 facilitates neuronal ferroptosis by promoting SUMOylation and inhibiting OPTN-selective autophagic degradation of ACSL4.
Suppression of NRF2 by photodynamic action to enhance bortezomib-triggered DNA damage for synergistic colorectal cancer therapy.
A bacterial RING ubiquitin ligase triggering stepwise degradation of BRISC via TOLLIP-mediated selective autophagy manipulates host inflammatory response.
Indole-3-carbinol inhibits PD-L1-mediated immune evasion in hepatocellular carcinoma via suppressing NF-κB p105 Ubiquitination.
CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1-Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis.
CIP2A promotes inflammation and exacerbates osteoarthritis by targeting CEMIP.
Lactate programs PBX1 lactylation and mesangial proliferation in lupus nephritis.
LMNB2-mediated high PD-L1 transcription triggers the immune escape of hepatocellular carcinoma.
GART promotes multiple myeloma malignancy via tumor stemness mediated by activating the HSP90α/CDK6/β-catenin axis.
ERK1-mediated GLYCTK2 phosphorylation promotes fructolysis to sustain glioblastoma survival under glucose deprivation.
UBE3C promotes pancreatic ductal adenocarcinoma progression by catalysing p53 ubiquitination.
Cullin 3-mediated ubiquitination restricts enterovirus D68 replication and is counteracted by viral protease 3C.
DTX2 attenuates Lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal β-oxidation in hepatocellular carcinoma.
Inhibition of CDC27 O-GlcNAcylation coordinates the antitumor efficacy in multiple myeloma through the autophagy-lysosome pathway.
Non-classic deubiquitinase USP13 inhibits bladder cancer metastasis through destabilizing cytoplasmic KDM3A.
COTE1 Regulates AMPKα2 Deubiquitination by Targeting WWP1 Activation to Promote Proliferation and Autophagy in Small Cell Lung Cancer.
DSK2-mediated degradation of F-box protein LAO1 and class I TCPs modulates the nitrogen starvation response.
OsbHLH062 negatively regulates Fe homeostasis by enhancing OsHRZ1 targeting OsPRIs for degradation.
SARS-CoV-2 encoded ORF3a interacts with YY1 to promote latent HCMV reactivation.
Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration.
SIRT5 promotes the osteo-inductive potential of BMP9 by stabilizing the HIF-1α protein in mouse embryonic fibroblasts.
Neoadjuvant Chemotherapy With Cisplatin Up-Regulates GSDMD to Enhance Oral Squamous Cell Carcinoma Metastasis Through MMP14-Mediated EMT Activation.
Ubiquitin Specific Protease 9X Regulates the Activation of ARK5 and Promotes Progression of Fibrotic Remodeling.
Deciphering the molecular mechanism of YY1/HIF1A modulating ovarian cancer angiogenesis based on single-cell transcriptomics technology.
Erdafitinib inhibits the tumorigenicity of MDA-MB-231 triple-negative breast cancer cells by inducing TRIM25/ubiquitin-dependent degradation of FGFR4.
YY1 enhances HIF-1α stability in tumor-associated macrophages to suppress anti-tumor immunity of prostate cancer in mice.
Aquaglyceroporin-7 ameliorates sorafenib resistance and immune evasion in hepatocellular carcinoma through inhibition of lipid accumulation.
Porcine reproductive and respiratory syndrome virus NSP5 exploited UBE2L6 to promote viral replication via antagonising host RLRs and ISGylation.
Pantothenic acid ameliorates hepatic fibrosis by targeting IGFBP6 to regulate the TGF-β/SMADs pathway.
Genetic modulation of lncPSMB1 confers non-syndromic cleft lip with or without cleft palate susceptibility by promoting cell apoptosis.
Renal tubular GSDME protects cisplatin nephrotoxicity by impeding OGT-STAT3-S100A7A axis in male mice.
Cathepsin B deficiency disrupts cortical development via PEG3, leading to depression-like behavior.
Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice.
UBE4B promotes gastric cancer proliferation and metastasis by mediating FAT4 ubiquitination and degradation.
ILF3 promotes colorectal cancer cell resistance to ferroptosis by enhancing cysteine uptake and GSH synthesis via stabilizing SLC3A2 mRNA.
circFTO binding with IGF2BP2 regulates trophoblast cells proliferation, migration, and invasion while mediating m6A modification of CCAR1 mRNA in spontaneous abortion.
SIGLEC1 ubiquitination and degradation induced by MARCHF3 protects ARPE19 retinal cells from high glucose-induced oxidative stress, inflammation, and apoptosis.
Activated TBK1 promotes ACSL1-mediated microglia lipid droplet accumulation and neuroinflammation in Parkinson's disease.
FXR acts as a therapeutic target for ulcerative colitis via suppressing ferroptosis.
Timosaponin AIII alleviates type 2 diabetes-induced cardiomyopathy by targeting galectin-3 (LGALS3).
Poldip2 Aggravates inflammation in diabetic retinopathy by impairing mitophagy via the AMPK/ULK1/Pink1 pathway.
Pembrolizumab promotes degradation of cyclin dependent kinase 6 and suppresses ovarian cancer progression in vitro.
MTMR14 depletion aggravates intrapulmonary inflammation and emphysema in experimental COPD through activating macrophage M1 polarization.
Trim65 mitigates doxorubicin-induced myocardial injury by reducing ferroptosis.
USP7 promotes PINK1/Parkin-dependent mitophagy to ameliorate cerebral ischemia-reperfusion injury by deubiquitinating and stabilizing SIRT1.
Impact of N-acetyltransferase 10 on macrophage activation and inflammation-induced cardiac dysfunction.
SLC44A2 negatively regulates mitochondrial fatty acid oxidation to suppress colorectal progression by blocking the MUL1-CPT2 interaction.
E3 ligase TRIM22 promotes melanoma proliferation by regulating cell cycle progression through K63-linked ubiquitination of p21.
Dehydrocostus lactone suppresses gastric cancer progression by targeting ACLY to inhibit fatty acid synthesis and autophagic flux.
LRRC45 accelerates bladder cancer development and ferroptosis inhibition via stabilizing NRF2 by competitively KEAP1 interaction.
USP7 facilitates deubiquitination of LRRC42 in colorectal cancer to accelerate tumorigenesis and augment Wnt/β-catenin signaling.
Vitamin K-dependent gamma-carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGFR.
Inhibitory effects of circR-127aa on gastric cancer progression and tumor growth.
Revealing the Mechanism of Protein Degradation in Postmortem Meat: The Role of Phosphorylation and Ubiquitination.
NEK8 promotes the progression of gastric cancer by reprogramming asparagine metabolism.
TRIM38 Inhibits Zika Virus by Upregulating RIG-I/MDA5 Pathway and Promoting Ubiquitin-Mediated Degradation of Viral NS3 Protein.
Nuclear farnesoid X receptor protects against bone loss by driving osteoblast differentiation through stabilizing RUNX2.
Deciphering transcription activity of mammalian early embryos unveils on/off of zygotic genome activation by protein translation/degradation.
A novel peptide encoded by circSRCAP confers resistance to enzalutamide by inhibiting the ubiquitin-dependent degradation of AR-V7 in castration-resistant prostate cancer.
PLAC8 attenuates pulmonary fibrosis and inhibits apoptosis of alveolar epithelial cells via facilitating autophagy.
COPS5 regulates osteosarcoma progression by upregulating KHSRP to promote Per2 mRNA decay.
NUC7738 Induces Apoptosis Through Modulating Stability of P53 in Esophageal Cancer Cells.
Modulation of the local angiotensin II: Suppression of ferroptosis and radiosensitivity in nasopharyngeal carcinoma via the HIF-1α-HILPDA axis.
METTL14-mediated m6A modification of ZFP14 inhibits clear cell renal cell carcinoma progression via promoting STAT3 ubiquitination.
N(6)-Methyladenosine modification mediated by METTL3 promotes DNA-PKcs expression to induce anlotinib resistance in osteosarcoma.
Targeting CDK2 Confers Vulnerability to Lenvatinib Via Driving Senescence in Anaplastic Thyroid Cancer.
Ubiquitination of CD47 Regulates Innate Anti-Tumor Immune Response.
HECW1-Mediated Ubiquitination of HIPK2 Drives Metastasis in Gastric Cancer Through the AKT Signaling Pathway.
RNF167 mediates atypical ubiquitylation and degradation of RLRs via two distinct proteolytic pathways.
Identification of a Potent and Selective CDK9 Degrader as a Targeted Therapeutic Option for the Treatment of Small-Cell Lung Cancer.
Rack1 promotes breast cancer stemness properties and tumorigenesis through the E2F1-SOX2 axis.
FTO-associated osteoclastogenesis promotes alveolar bone resorption in apical periodontitis male rat via the HK1/USP14/RANK pathway.
Non-catalytic mechanisms of KMT5C regulating hepatic gluconeogenesis.
HDAC1-3 inhibition triggers NEDD4-mediated CCR2 downregulation and attenuates immunosuppression in myeloid-derived suppressor cells.
The functional study of novel KLHL3 missense mutations associated with pseudohypoaldosteronism type II.
SIRT5 Facilitates Liver Steatosis Progression via Promoting SDH Desuccinylation During High-Fat Diet Feeding.
MARCH8/NSUN6/ROS-mediated DNA damage positive feedback loop regulates cisplatin resistance in osteosarcoma.
Mechanism of NUMBL enhancing axitinib resistance in clear cell renal cell carcinoma by UCHL1-mediated deubiquitination of MMP9.
Astragalus Polysaccharide Enhances O-GlcNAcylation Through OGT to Improve Intervertebral Disc Degeneration in Rats.
CRIP1 exacerbates osteoarthritis progression by recruiting UBE3A to induce the ubiquitination-mediated degradation of MFGE8.
Tauroursodeoxycholic acid ameliorates palmitic acid induced endoplasmic reticulum stress and impaired autophagy via IRE1- XBP1-FoxO1 pathway in KGN cells.
Overcoming ELDR-mediated cancer cell survival in vitro and in vivo via sphingomyelin-driven TRPML1 inactivation and TFEB suppression through lysosomal HSP70 targeting.
1,8-Cineole ameliorates vascular endothelial senescence in diabetes mellitus by directly targeting and deubiquitinating PPAR-γ in vivo and in vitro.
Bax inhibitor-1 like (CmoBI1L) functions in pumpkin salt tolerance by stabilizing Na(+) transporters and modulating the transcription of peroxidases.
Homocysteine Exacerbates Pulmonary Fibrosis via Orchestrating Syntaxin 17 Homocysteinylation of Alveolar Type II Cells.
UBE2M inhibits neoplastic cell proliferation via MKK7-JNK-EGR1 axis in melanoma.
Lysophosphatidylethanolamine 18:1 drives clear cell renal cell carcinoma by stabilizing SIRT6 to reprogram lipid metabolism.
STUB1-mediated PGC-1α ubiquitination promotes postoperative cognitive dysfunction in aged mice via modulating autophagy-lysosome machinery.
Lathyrol Exerts Anti-Pulmonary Fibrosis Effects by Activating PPARγ to Inhibit the TGF-β/Smad Pathway.
LRRC1 Promotes Angiogenesis Through Regulating AKT/GSK3β/β-Catenin/VEGFA Signaling Pathway in Hepatocellular Carcinoma.
Decitabine promotes degradation of DNMT1 and EZH2 via the ubiquitination pathway and inhibits colorectal cancer progression.
Liquid-liquid phase separation of ATXN2L enhances mRNA translation in hepatocellular carcinoma.
TRIM16 mediates YAP1 K63-linked ubiquitination to alleviate sepsis-induced acute liver injury through YAP/Nrf2 axis in mice.
Exploratory Analysis of Autophagy-Lysosomal Pathway Proteins in Dermal Fibroblasts as Potential Peripheral Biomarkers for Alzheimer's Disease: A Pilot Study.
FLASH-AWAY: Intrabody-Directed Targeting of Optogenetic Tools for Protein Degradation.
RNF152-mediated, ubiquitin-dependent degradation of HSP27 activates the PI3K/AKT pathway, driving synovial inflammatory cascades in TMJOA.
WWP2-induced inhibition of hepatocellular carcinoma cellular senescence via the ubiquitination and degradation of p21.
FBXW7 regulates MAP7 through ubiquitination to affect the phenotypic characteristics and paclitaxel sensitivity of paclitaxel-resistant lung adenocarcinoma cells.
Inhibitors of the 20S proteasome β5 subunit as potent and selective agents against Trichomonas vaginalis.
Upregulation of E3 ligase UBR2 in acetaldehyde-treated C2C12 myotubes and its potential involvement in fast-twitch muscle atrophy in alcohol-fed rats.
KLX ameliorates liver cancer progression by mediating ZBP1 transcription and ubiquitination and increasing ZBP1-induced PANoptosis.
Otubain 2 stabilizes TNF‑receptor associated factor 3 to accelerate bone fracture healing.
A novel designed fully peptide-based PROTAC, FPP29, demonstrates its potent cytotoxic effects to liver cancer HCCLM3 cells by targeting FOXM1.
Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis.
USP5-Rich Apoptotic Extracellular Vesicles Regulate Nucleus Pulposus Cells Apoptosis and DNA Damage Repair by Preventing E2F1 Proteasomal Degradation.
Circ847 upregulation via CAFs suppresses salivary adenoid cystic carcinoma progression through VIM-EMT.
Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8-AS1/GPX4 Axis in Intrahepatic Cholangiocarcinoma.
Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia-Inducible Factor-1 Signaling Pathway.
Teniposide Triggers DNA Repair Inhibition by Binding and Ubiquitination of Apurinic/Apyrimidinic Endonuclease 1 to Boost Oxidative DNA Damage for Lung Cancer Destruction.
Machine learning-based proteomics profiling of ALS identifies downregulation of RPS29 that maintains protein homeostasis and STMN2 level.
Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis.
Targeting the SYVN1-EGFR axis: a breakthrough strategy for TKI-resistant NSCLC.
Nascent liver proteome reveals enzymes and transcription regulators under physiological and alcohol exposure conditions.
NR3C1/GLMN-Mediated FKBP12.6 Ubiquitination Disrupts Calcium Homeostasis and Impairs Mitochondrial Quality Control in Stress-Induced Myocardial Damage.
CX26 promotes pancreatic cancer progression by competitively inhibiting interaction of c-Myc with PSMD2 and enhancing c-Myc stability.
Oroxin A suppresses colorectal tumor growth by regulating the TRIM24-mediated ferroptosis and TSPO pathway.
Synthesis of USP5-IN-1 derivatives as novel USP5 inhibitors with potent activity against cholangiocarcinoma cells.
SKP2 ubiquitylation modifies IDH1 to regulate hepatoblastoma cell cycle and glucose metabolism.
Tobacco Smoking Rewires Cell Metabolism by Inducing GAPDH Succinylation to Promote Lung Cancer Progression.
Quercetin alleviates LPS/iE-DAP-induced liver injury by suppressing ferroptosis via regulating ferritinophagy and intracellular iron efflux.
PLEKHA4 knockdown induces apoptosis in melanoma cells through the MAPK and β‑catenin signaling pathways.
Long noncoding RNA USP30-AS1 promotes influenza A virus replication by enhancing PHB1 function.
NLRC3 affects the development of psoriasis by modulating the NF-κB signaling pathway mediated inflammatory response through its interaction with TRAF6.
CKAP4 in hepatocellular carcinoma: competitive RETREG1/FAM134B binding, reticulophagy regulation, and cancer progression.
USP4 depletion-driven RAB7A ubiquitylation impairs autophagosome-lysosome fusion and aggravates periodontitis.
SAE1 promotes tumor cell malignancy via SUMOylation and liquid-liquid phase separation facilitated nuclear export of p27.
Bruceine A Inhibits Cell Proliferation by Targeting the USP13/PARP1 Signalling Pathway in Multiple Myeloma.
LINC00323 knockdown suppresses the proliferation, migration, and vascular mimicry of non-small cell lung cancer cells by promoting ubiquitinated degradation of AKAP1.
TCDD inhibits the proliferation of C17.2 cells through the activation of the c-Cbl/β-catenin signaling pathway.
Cannabidiol Enhances the Anticancer Activity of Etoposide on Prostate Cancer Cells.
Plant salicylic acid signaling is inhibited by a cooperative strategy of two powdery mildew effectors.
ELANE enhances KEAP1 protein stability and reduces NRF2-mediated ferroptosis inhibition in metabolic dysfunction-associated fatty liver disease.
Endothelial USP11 drives VEGFR2 signaling and angiogenesis via PRDX2/c-MYC axis.
The Role and Mechanism of TRIM13 Regulation of TRAF6 Ubiquitination in the Synergy of Inflammatory Responses and Neurotoxicity Induced by METH and HIV- 1 Tat Protein in Astrocytes.
SIRT5-mediated BCAT1 desuccinylation and stabilization leads to ferroptosis insensitivity and promotes cell proliferation in glioma.
Trifluridine/tipiracil induces ferroptosis by targeting p53 via the p53-SLC7A11 axis in colorectal cancer 3D organoids.
USP2-induced upregulation of LEF1 through deubiquitination relieves osteoporosis development by promoting the osteogenic differentiation of bone marrow mesenchymal stem cells.
PYK2 promotes cell proliferation and epithelial-mesenchymal transition in endometriosis by phosphorylating Snail1.
Glucosidase alpha neutral C promotes influenza virus replication by inhibiting proteosome-dependent degradation of hemagglutinin.
Y4 RNA fragment alleviates myocardial injury in heart transplantation via SNRNP200 to enhance IL-10 mRNA splicing.
TMEM160 inhibits KEAP1 to suppress ferroptosis and induce chemoresistance in gastric cancer.
CircPRKCA facilitates esophageal squamous cell carcinoma metastasis via m5C-dependent CSF2 mRNA stabilization.
Berberine Alleviates Ischemic Brain Injury by Enhancing Autophagic Flux via Facilitation of TFEB Nuclear Translocation.
O-GlcNAcylated RALY Contributes to Hepatocellular Carcinoma Cells Proliferation by Regulating USP22 mRNA Nuclear Export.
The m6A modification-mediated positive feedback between glycolytic lncRNA SLC2A1-DT and c-Myc promotes tumorigenesis of hepatocellular carcinoma.
Mechanistic study of celastrol-mediated inhibition of proinflammatory activation of macrophages in IgA nephropathy via down-regulating ECM1.
HSPD1 Supports Osteosarcoma Progression through Stabilizing ATP5A1 and thus Activation of AKT/mTOR Signaling.
Vaginal Tritrichomonas foetus infection in mice as an in vivo model for drug development against Trichomonas vaginalis.
α-Synuclein-mediated mitochondrial translocation of cofilin-1 leads to oxidative stress and cell apoptosis in PD.
Ubiquitination contributes to the regulation of GDP-mannose pyrophosphorylase B activity.
USP50 regulates NLRP3 inflammasome activation in duodenogastric reflux-induced gastric tumorigenesis.
Abnormal mitochondrial iron metabolism damages alveolar type II epithelial cells involved in bleomycin-induced pulmonary fibrosis.
Photoreceptor-targeted extracellular vesicles-mediated delivery of Cul7 siRNA for retinal degeneration therapy.
GSDMD suppresses keratinocyte differentiation by inhibiting FLG expression and attenuating KCTD6-mediated HDAC1 degradation in atopic dermatitis.
LACTB suppresses liver cancer progression through regulation of ferroptosis.
The mechanism of RGS5 regulating gastric cancer mismatch repair protein.
USP18 Stabilized FTO Protein to Activate Mitophagy in Ischemic Stroke Through Repressing m6A Modification of SIRT6.
LUCAT1 Activates the Malignant Phenotypes of Lung Cancer Cells via Regulating P53 Ubiquitination.
Increased CCT5 expression is a potential unfavourable factor promoting the growth of nasopharyngeal carcinoma.
Phosphorylation of RasGRP1 by Shc3 prevents RasGRP1 degradation and contributes to Ras/c-Jun activation in hepatocellular carcinoma.
Ubiquitination of p21 by E3 ligase RNF135 promotes the proliferation of human glioblastoma cells.
KIAA0753 enhances osteoblast differentiation suppressed by diabetes.
Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH.
Gentiopicroside ameliorates glucose and lipid metabolism in T2DM via targeting FGFR1.
CCDC68 Maintains Mitotic Checkpoint Activation by Promoting CDC20 Integration into the MCC.
Uremic Toxin Receptor AhR Facilitates Renal Senescence and Fibrosis via Suppressing Mitochondrial Biogenesis.
Tudor-SN exacerbates pathological vascular remodeling by promoting the polyubiquitination of PTEN via NEDD4-1.
RNA binding protein ELAVL1-mediated USP33 stabilizes HIF1A to promote pathological proliferation, migration and angiogenesis of RECs.
Nogo-B inhibition facilitates cholesterol metabolism to reduce hypercholesterolemia.
gp78-regulated KAP1 phosphorylation induces radioresistance in breast cancer by facilitating PPP1CC/PPP2CA ubiquitination.
Deubiquitinase USP10 promotes osteosarcoma autophagy and progression through regulating GSK3β-ULK1 axis.
ARMCX1 inhibits lung adenocarcinoma progression by recruiting FBXW7 for c-Myc degradation.
Promotion of endoplasmic reticulum retrotranslocation by overexpression of E3 ubiquitin-protein ligase synoviolin 1 reduces endoplasmic reticulum stress and preserves cone photoreceptors in cyclic nucleotide-gated channel deficiency.
Molecular basis of CX-5461-induced DNA damage response in primary vascular smooth muscle cells.
Translation stalling induced mitochondrial entrapment of ribosomal quality control related proteins offers cancer cell vulnerability.
The Syvn1 inhibits neuronal cell ferroptosis by activating Stat3/Gpx4 axis in rat with spinal cord injury.
The tumor suppressor Parkin exerts anticancer effects through regulating mitochondrial GAPDH activity.
UBE2S promotes glycolysis in hepatocellular carcinoma by enhancing E3 enzyme-independent polyubiquitination of VHL.
LncRNA MAAMT facilitates macrophage recruitment and proinflammatory activation and exacerbates autoimmune myocarditis through the SRSF1/NF-κB axis.
Genetic and pharmacological targeting of XBP1 alleviates hepatic ischemia reperfusion injury by enhancing FoxO1-dependent mitophagy.
The suppression of OTUD7B by miR-491-5p enhances the ubiquitination of VEGFA to suppress vascular mimicry in non-small cell lung cancer.
UBE2C orchestrates bone formation through stabilization of SMAD1/5.
Targeting SMYD2 promotes ferroptosis and impacts the progression of pancreatic cancer through the c-Myc/NCOA4 axis-mediated ferritinophagy.
Paeoniflorin suppresses ferroptosis after traumatic brain injury by antagonizing P53 acetylation.
Cinnamaldehyde activates AMPK/PGC-1α pathway via targeting GRK2 to ameliorate heart failure.
CDK4/6 Inhibitors Impede Chemoresistance and Inhibit Tumor Growth of Small Cell Lung Cancer.
Hypoxia-induced DTL promotes the proliferation, metastasis, and sorafenib resistance of hepatocellular carcinoma through ubiquitin-mediated degradation of SLTM and subsequent Notch pathway activation.
Ubiquitin-mediated degradation of SlPsbS regulates low night temperature tolerance in tomatoes.
Lysosomal Ca(2+) release-facilitated TFEB nuclear translocation alleviates ischemic brain injury by attenuating autophagic/lysosomal dysfunction in neurons.
Interplay between acetylation and ubiquitination controls PSAT1 protein stability in lung adenocarcinoma.
Superenhancer-driven circRNA Myst4 involves in pulmonary artery smooth muscle cell ferroptosis in pulmonary hypertension.
Nesfatin-1 enhances vascular smooth muscle calcification through facilitating BMP-2 osteogenic signaling.
Tumor-associated macrophages/C-X-C motif chemokine ligand 1 promotes breast cancer autophagy-mediated chemoresistance via IGF1R/STAT3/HMGB1 signaling.
O-GlcNAcylation regulation of RIPK1-dependent apoptosis dictates sensitivity to sunitinib in renal cell carcinoma.
MDM2 accelerated renal senescence via ubiquitination and degradation of HDAC1.
O-GlcNAcylation of circadian clock protein Bmal1 impairs cognitive function in diabetic mice.
Rack1 regulates B-cell development and function by binding to and stabilizing the transcription factor Pax5.
CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity.
Activation of BK channels prevents diabetes-induced osteopenia by regulating mitochondrial Ca(2+) and SLC25A5/ANT2-PINK1-PRKN-mediated mitophagy.
Targeting USP11 regulation by a novel lithium-organic coordination compound improves neuropathologies and cognitive functions in Alzheimer transgenic mice.
Luteolin detoxifies DEHP and prevents liver injury by degrading Uroc1 protein in mice.
CaMKII Exacerbates Doxorubicin-Induced Cardiotoxicity by Promoting Ubiquitination Through USP10 Inhibition.
Mitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 Deubiquitination.
Psmb8 inhibits mitochondrial fission and alleviates myocardial ischaemia/reperfusion injury by targeting Drp1 degradation.
ΔNp63α promotes radioresistance in esophageal squamous cell carcinoma through the PLEC-KEAP1-NRF2 feedback loop.
Lactylation stabilizes TFEB to elevate autophagy and lysosomal activity.
14-3-3 proteins inhibit autophagy by regulating SINAT-mediated proteolysis of ATG6 in Arabidopsis.
CLIP170 enhancing FOSL1 expression via attenuating ubiquitin-mediated degradation of β-catenin drives renal cell carcinoma progression.
Mitophagy-Enhanced Nanoparticle-Engineered Mitochondria Restore Homeostasis of Mitochondrial Pool for Alleviating Pulmonary Fibrosis.
Arginine methylation-dependent TRIM47 stability mediated by CARM1 promotes the metastasis of hepatocellular carcinoma.
Tripartite motif 25 inhibits protein aggregate degradation during PRRSV infection by suppressing p62-mediated autophagy.
SPIN1 accelerates tumorigenesis and confers radioresistance in non-small cell lung cancer by orchestrating the FOXO3a/FOXM1 axis.
MDM4 inhibits ferroptosis in p53 mutant colon cancer via regulating TRIM21/GPX4 expression.
Gaudichaudione H ameliorates liver fibrosis and inflammation by targeting NRF2 signaling pathway.
Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes.
N6-Methyladenosine Modification of lncCCKAR-5 Regulates Autophagy in Human Umbilical Cord Mesenchymal Stem Cells by Destabilizing LMNA and Inhibits Diabetic Wound Healing.
Phosphorylated SHMT2 Regulates Oncogenesis Through m(6)A Modification in Lung Adenocarcinoma.
MiR-31-5p alleviates septic cardiomyopathy by targeting BAP1 to inhibit SLC7A11 deubiquitination and ferroptosis.
LncRNA RGMB-AS1 inhibits HMOX1 ubiquitination and NAA10 activation to induce ferroptosis in non-small cell lung cancer.
Contrasting Impacts of Ubiquitin Overexpression on Arabidopsis Growth and Development.
ECHDC2 inhibits the proliferation of gastric cancer cells by binding with NEDD4 to degrade MCCC2 and reduce aerobic glycolysis.
Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop.
RNF125‑mediated ubiquitination of MCM6 regulates the proliferation of human liver hepatocellular carcinoma cells.
Integrin β8 prevents pericyte-myofibroblast transition and renal fibrosis through inhibiting the TGF-β1/TGFBR1/Smad3 pathway in diabetic kidney disease.
β-Sitosterol targets ASS1 for Nrf2 ubiquitin-dependent degradation, inducing ROS-mediated apoptosis via the PTEN/PI3K/AKT signaling pathway in ovarian cancer.
USP46 enhances tamoxifen resistance in breast cancer cells by stabilizing PTBP1 to facilitate glycolysis.
Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy.
BRCC36 Deubiquitinates HMGCR to Regulate the Interplay Between Ferroptosis and Pyroptosis.
A regulatory module comprising G3BP1-FBXL5-IRP2 axis determines sodium arsenite-induced ferroptosis.
Cardiac injury activates STING signaling via upregulating SIRT6 in macrophages after myocardial infarction.
NSP6 inhibits the production of ACE2-containing exosomes to promote SARS-CoV-2 infectivity.
UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5.
Ubiquitin-specific protease 54 regulates GLUT1-mediated aerobic glycolysis to inhibit lung adenocarcinoma progression by modifying p53 degradation.
MGMT activated by Wnt pathway promotes cisplatin tolerance through inducing slow-cycling cells and nonhomologous end joining in colorectal cancer.
Chaperones Hsc70 and Hsp70 play distinct roles in the replication of bocaparvovirus minute virus of canines.
E3 ubiquitin ligase CHIP interacts with transferrin receptor 1 for degradation and promotes cell proliferation through inhibiting ferroptosis in hepatocellular carcinoma.
OLFM4 promotes the progression of intestinal metaplasia through activation of the MYH9/GSK3β/β-catenin pathway.
P53 upregulation by USP7-engaging molecular glues.
Novel TUBA4A variant causes congenital myopathy with focal myofibrillar disorganisation.
RUNX1 regulates MCM2/CDC20 to promote COAD progression modified by deubiquitination of USP31.
The COP9 signalosome stabilized MALT1 promotes Non-Small Cell Lung Cancer progression through activation of NF-κB pathway.
Smooth muscle NF90 deficiency ameliorates diabetic atherosclerotic calcification in male mice via FBXW7-AGER1-AGEs axis.
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway.
CBLC promotes the development of colorectal cancer by promoting ABI1 degradation to activate the ERK signaling pathway.
Neuronal activity promotes secretory autophagy for the extracellular release of α-synuclein.
USP7 promotes cardiometabolic disorders and mitochondrial homeostasis dysfunction in diabetic mice via stabilizing PGC1β.
RACK1 enhances STAT3 stability and promotes T follicular helper cell development and function during blood-stage Plasmodium infection in mice.
USP9X regulates the proliferation, survival, migration and invasion of gastric cancer cells by stabilizing MTH1.
CHIP-mediated ubiquitin degradation of BCAT1 regulates glioma cell proliferation and temozolomide sensitivity.
Identification of mechanism of the oncogenic role of FGFR1 in papillary thyroid carcinoma.
Dual-Responsive Epigenetic Inhibitor Nanoprodrug Combined with Oncolytic Virus Synergistically Boost Cancer Immunotherapy by Igniting Gasdermin E-Mediated Pyroptosis.
CircSMAD3 represses SMAD3 phosphorylation and ameliorates cardiac remodeling by recruiting YBX1.
WWP1 inhibition increases SHP2 inhibitor efficacy in colorectal cancer.
An engineered DNA aptamer-based PROTAC for precise therapy of p53-R175H hotspot mutant-driven cancer.
NEDD4L Promotes IκBα Ubiquitination and Degradation in the Pathogenesis of Diabetic Retinopathy.
New mode of action of curcumin on prostate cancer cells: Modulation of endoplasmic reticulum-associated degradation mechanism and estrogenic signaling.
Pseudorabies virus inhibits progesterone-induced inactivation of TRPML1 to facilitate viral entry.
IL-22-Induced Ubiquitin-Specific Protease 15 Promotes Proliferation and Inflammation of Keratinocytes through Stabilization of Squamous Cell Carcinoma Antigen 2.
Taxifolin inhibits melanoma proliferation/migration impeding USP18/Rac1/JNK/β-catenin oncogenic signaling.
Stability and function of RCL1 are dependent on the interaction with BMS1.
Nicotinamide mononucleotide attenuates airway epithelial barrier dysfunction via inhibiting SIRT3 SUMOylation in asthma.
The feedback loop of EFTUD2/c-MYC impedes chemotherapeutic efficacy by enhancing EFTUD2 transcription and stabilizing c-MYC protein in colorectal cancer.
TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.
Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells.
LINC00571 drives tricarboxylic acid cycle metabolism in triple-negative breast cancer through HNRNPK/ILF2/IDH2 axis.
N-arachidonoylphenolamine alleviates ischaemia/reperfusion-induced cardiomyocyte necroptosis by restoring proteasomal activity.
Natural Product Baohuoside I Impairs the Stability and Membrane Location of MRP2 Reciprocally Regulated by SUMOylation and Ubiquitination in Hepatocytes.
PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer.
miR-26a exerts broad-spectrum antiviral effects via the enhancement of RIG-I-mediated type I interferon response by targeting USP15.
Acylated Ghrelin Activates PI3K/mTOR Signaling Pathway by Promoting ThPOK Acetylation to Promote Milk Fat Synthesis in Bovine Mammary Epithelial Cells.
Shank3 ameliorates neuronal injury after cerebral ischemia/reperfusion via inhibiting oxidative stress and inflammation.
Degradation of AZGP1 suppresses the progression of breast cancer cells via TRIM25.
ABLIM1, a novel ubiquitin E3 ligase, promotes growth and metastasis of colorectal cancer through targeting IĸBα ubiquitination and activating NF-ĸB signaling.
Upregulation of TRIM16 mitigates doxorubicin-induced cardiotoxicity by modulating TAK1 and YAP/Nrf2 pathways in mice.
WWP2 protects against sepsis-induced cardiac injury through inhibiting cardiomyocyte ferroptosis.
Regulator of Ribosome Synthesis 1 (RRS1) Stabilizes GRP78 and Promotes Breast Cancer Progression.
The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3.
KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC.
WSB1, as an E3 ligase, restrains myocardial ischemia-reperfusion injury by activating β-catenin signaling via promoting GSK3β ubiquitination.
The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer.
Inhibition of RIPK1 alleviating vascular smooth muscle cells osteogenic transdifferentiation via Runx2.
HECW1 restrains cervical cancer cell growth by promoting DVL1 ubiquitination and downregulating the activation of Wnt/β-catenin signaling.
Hypothermic oxygenated perfusion inhibits CLIP1-mediated TIRAP ubiquitination via TFPI2 to reduce ischemia‒reperfusion injury of the fatty liver.
USP28 promotes tumor progression and glycolysis by stabilizing PKM2/Hif1-α in cholangiocarcinoma.
ITFG2 as a NEDD4-2 inhibitor: Preserving calcium homeostasis to prevent myocardial ischemic injury.
Discovery of novel 20S proteasome subunit β5 PROTAC degraders as potential therapeutics for pharyngeal carcinoma and Bortezomib-resistant multiple myeloma.
Cepharanthine sensitizes gastric cancer cells to chemotherapy by targeting TRIB3-FOXO3-FOXM1 axis to inhibit autophagy.
Aloe Emodin Alleviates Radiation-Induced Heart Disease via Blocking P4HB Lactylation and Mitigating Kynurenine Metabolic Disruption.
CDK9 recruits HUWE1 to degrade RARα and offers therapeutic opportunities for cutaneous T-cell lymphoma.
The role of the PI3K/AKT/mTOR pathway in mediating PD-L1 upregulation during fibroblast transdifferentiation.
The facilitating effects of KRT80 on chemoresistance, lipogenesis, and invasion of esophageal cancer.
PTGES3 proteolysis using the liposomal peptide-PROTAC approach.
Pyroptosis mediated by Parkin-NLRP3 negative feedback loop contributed to Parkinson's disease induced by rotenone.
Transcription factors PuNAC37/PuWRKY74 and E3 ubiquitin ligase PuRDUF2 inhibit volatile ester synthesis in 'Nanguo' pear.
Nrf2/NRF1 signaling activation and crosstalk amplify mitochondrial biogenesis in the treatment of triptolide-induced cardiotoxicity using calycosin.
NIR-715 photodynamic therapy induces immunogenic cancer cell death by enhancing the endoplasmic reticulum stress response.
RRM1 promotes homologous recombination and radio/chemo-sensitivity via enhancing USP11 and E2F1-mediated RAD51AP1 transcription.
Development of Novel Silicon-Based Hydrophobic Tags (SiHyT) for Targeted Proteins Degradation.
GDF15 induces chemoresistance to oxaliplatin by forming a reciprocal feedback loop with Nrf2 to maintain redox homeostasis in colorectal cancer.
USP19 Stabilizes TAK1 to Regulate High Glucose/Free Fatty Acid-induced Dysfunction in HK-2 Cells.
Deubiquitinating enzyme OTUD4 stabilizes RBM47 to induce ATF3 transcription: a novel mechanism underlying the restrained malignant properties of ccRCC cells.
Polydatin attenuates diabetic renal inflammatory fibrosis via the inhibition of STING pathway.
Ubiquitin-specific peptidase 15 regulates the TFAP4/PCGF1 axis facilitating liver metastasis of colorectal cancer and cell stemness.
The Deubiquitinase USP22-Stabilized COL17A1 Promotes Lung Adenocarcinoma Progression.
CircNCX1 modulates cardiomyocyte proliferation through promoting ubiquitination of BRG1.
Melatonin alleviates palmitic acid-induced mitochondrial dysfunction by reducing oxidative stress and enhancing autophagy in bovine endometrial epithelial cells.
A clinical-stage Nrf2 activator suppresses osteoclast differentiation via the iron-ornithine axis.
N-ethylmaleimide-sensitive factor elicits a neuroprotection against ischemic neuronal injury by restoring autophagic/lysosomal dysfunction.
SERPINH1 modulates apoptosis by inhibiting P62 ubiquitination degradation to promote bone metastasis of prostate cancer.
Pyrogallol promotes growth arrest by activating the p53-mediated up-regulation of p21 and p62/SQSTM1-dependent degradation of β-catenin in nonsmall cell lung cancer cells.
APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy.
STING deficiency alleviates ferroptosis through FPN1 stabilization in diabetic kidney disease.
Hydrogen sulfide improves endothelial barrier function by modulating the ubiquitination degradation of KLF4 through TRAF7 S-sulfhydration in diabetic aorta.
p53 accelerates endothelial cell senescence in diabetic retinopathy by enhancing FoxO3a ubiquitylation and degradation via UBE2L6.
Spinal sirtuin 2 attenuates bone cancer pain by deacetylating FoxO3a.
Chronic Rapamycin administration via drinking water mitigates the pathological phenotype in a Krabbe disease mouse model through autophagy activation.
Fn-OMV potentiates ZBP1-mediated PANoptosis triggered by oncolytic HSV-1 to fuel antitumor immunity.
Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome.
N6-methyladenosine-modified circSLCO1B3 promotes intrahepatic cholangiocarcinoma progression via regulating HOXC8 and PD-L1.
Physalin H ameliorates LPS-induced acute lung injury via KEAP1/NRF2 axis.
Fatty liver disease protective MTARC1 p.A165T variant reduces the protein stability of MTARC1.
An LRPPRC-HAPSTR1-PSMD14 interaction regulates tumor progression in ovarian cancer.
Circ_005077 accelerates myocardial lipotoxicity induced by high-fat diet via CyPA/p47PHOX mediated ferroptosis.
FBXL8 inhibits post-myocardial infarction cardiac fibrosis by targeting Snail1 for ubiquitin-proteasome degradation.
Acidosis activates breast cancer ferroptosis through ZFAND5/SLC3A2 signaling axis and elicits M1 macrophage polarization.
Murine Myoblasts Exposed to SYUIQ-5 Acquire Senescence Phenotype and Differentiate into Sarcopenic-Like Myotubes, an In Vitro Study.
Phosphorylation by IKKβ Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer.
NLRP3 Regulates Mandibular Healing through Interaction with UCHL5 in MSCs.
Nicotinamide adenine dinucleotide kinase promotes lymph node metastasis of NSCLC via activating ID1 expression through BMP pathway.
Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6.
UBE2S targets RPL26 for ubiquitination and degradation to promote non-small cell lung cancer progression via regulating c-Myc.
NPM1 promotes nasopharyngeal carcinoma metastasis and stemness by recruiting Mdm2 to induce the ubiquitination-mediated degradation of p53.
Fangchinoline alleviates cognitive impairments through enhancing autophagy and mitigating oxidative stress in Alzheimer's disease models.
EVC-EVC2 complex stability and ciliary targeting are regulated by modification with ubiquitin and SUMO.
E3 ligase ATL5 positively regulates seed longevity by mediating the degradation of ABT1 in Arabidopsis.
EGFR-T790M Mutation-Derived Interactome Rerouted EGFR Translocation Contributing to Gefitinib Resistance in Non-Small Cell Lung Cancer.
Hepatocyte CD36 modulates UBQLN1-mediated proteasomal degradation of autophagic SNARE proteins contributing to septic liver injury.
Triiodothyronine positively regulates endoplasmic reticulum-associated degradation (ERAD) and promotes androgenic signaling in androgen-dependent prostate cancer cells.
GART Functions as a Novel Methyltransferase in the RUVBL1/β-Catenin Signaling Pathway to Promote Tumor Stemness in Colorectal Cancer.
The NLRP11 Protein Bridges the Histone Lysine Acetyltransferase KAT7 to Acetylate Vimentin in the Early Stage of Lung Adenocarcinoma.
Phosphorylation of PPDPF via IL6-JAK2 activates the Wnt/β-catenin pathway in colorectal cancer.
MDM2 upregulation induces mitophagy deficiency via Mic60 ubiquitination in fetal microglial inflammation and consequently neuronal DNA damage caused by exposure to ZnO-NPs during pregnancy.
Arabidopsis PLANT U-BOX44 down-regulates osmotic stress signaling by mediating Ca2+-DEPENDENT PROTEIN KINASE4 degradation.
ITCH-Mediated Ubiquitylation of ITGB3 Promotes Cell Proliferation and Invasion of Ectopic Endometrial Stromal Cells in Ovarian Endometriosis.
Loss of hepatic FTCD promotes lipid accumulation and hepatocarcinogenesis by upregulating PPARγ and SREBP2.
TMED2 Induces Cisplatin Resistance in Breast Cancer via Targeting the KEAP1-Nrf2 Pathway.
Parkin regulates IGF2BP3 through ubiquitination in the tumourigenesis of cervical cancer.
UV-B irradiation-activated E3 ligase GmILPA1 modulates gibberellin catabolism to increase plant height in soybean.
Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.
TRIM21 mediates the synergistic effect of Olaparib and Sorafenib by degrading BRCA1 through ubiquitination in TNBC.
PIWI-interacting RNA expression regulates pathogenesis in a Caenorhabditis elegans model of Lewy body disease.
TRAF7-targeted HOXA5 acts as a tumor suppressor in prostate cancer progression and stemness via transcriptionally activating SPRY2 and regulating MEK/ERK signaling.
Mitigating a TDP-43 proteinopathy by targeting ataxin-2 using RNA-targeting CRISPR effector proteins.
DEPDC1B-mediated USP5 deubiquitination of β-catenin promotes breast cancer metastasis by activating the wnt/β-catenin pathway.
Polydopamine-loaded prunetin nanomaterials activate DRD2 to reduce UV-induced inflammation by stabilizing and promoting Nrf2 nuclear translocation.
UFMylation of HRD1 regulates endoplasmic reticulum homeostasis.
USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A.
Targeting TLK2 inhibits the progression of gastric cancer by reprogramming amino acid metabolism through the mTOR/ASNS axis.
Orosomucoid proteins limit endoplasmic reticulum stress in plants.
Dl-3-n-butylphthalide exerts neuroprotective effects by modulating hypoxia-inducible factor 1-alpha ubiquitination to attenuate oxidative stress-induced apoptosis.
Combination of PARP inhibitor and CDK4/6 inhibitor modulates cGAS/STING-dependent therapy-induced senescence and provides "one-two punch" opportunity with anti-PD-L1 therapy in colorectal cancer.
Downregulation of pro-surfactant protein B contributes to the recurrence of early-stage non-small cell lung cancer by activating PGK1-mediated Akt signaling.
The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer.
Fucoidan Ameliorates Ferroptosis in Ischemia-reperfusion-induced Liver Injury through Nrf2/HO-1/GPX4 Activation.
Metformin Suppresses Stemness of Non-Small-Cell Lung Cancer Induced by Paclitaxel through FOXO3a.
Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway.
FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression.
Cullin 5 aggravates hypoxic pulmonary hypertension by activating TRAF6/NF-κB/HIF-1α/VEGF.
CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signaling pathway.
Intrathecal delivery of AAV-NDNF ameliorates disease progression of ALS mice.
FGF21 protects against doxorubicin-induced cardiotoxicity by inhibiting connexin 43 ubiquitination.
Molecular functions of the double-sided and inverted ubiquitin-interacting motif found in Xenopus tropicalis cryptochrome 6.
OTUB1 Catalytic-Independently Deubiquitinates TGFBI and Mediates the Angiogenesis in Infantile Hemangioma by Regulating Glycolysis.
Polydopamine Nanoparticles Targeting Ferroptosis Mitigate Intervertebral Disc Degeneration Via Reactive Oxygen Species Depletion, Iron Ions Chelation, and GPX4 Ubiquitination Suppression.
miR-137-LAPTM4B regulates cytoskeleton organization and cancer metastasis via the RhoA-LIMK-Cofilin pathway in osteosarcoma.
The oncogenic role of NF1 in gallbladder cancer through regulation of YAP1 stability by direct interaction with YAP1.
SYTL2 promotes metastasis of prostate cancer cells by enhancing FSCN1-mediated pseudopodia formation and invasion.
HDAC4 mediated LHPP deacetylation enhances its destabilization and promotes the proliferation and metastasis of nasopharyngeal carcinoma.
RSL1D1 knockdown induces ferroptosis and mediates ferrous iron accumulation in senescent cells by inhibiting FTH1 mRNA stability.
Downregulation of Histone H4 Lysine 16 Acetylation Ameliorates Autophagic Flux by Resuming Lysosomal Functions in Ischemic Neurons.
TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury.
p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors.
Deubiquitinating enzyme USP11 promotes renal tubular cell senescence and fibrosis via inhibiting the ubiquitin degradation of TGF-β receptor II.
MYB30 integrates light signals with antioxidant biosynthesis to regulate plant responses during postsubmergence recovery.
S1PR1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lung.
1,25(OH)(2) D(3) induced vitamin D receptor signaling negatively regulates endoplasmic reticulum-associated degradation (ERAD) and androgen receptor signaling in human prostate cancer cells.
Ribosome Biogenesis Regulator 1 Homolog (RRS1) Promotes Cisplatin Resistance by Regulating AEG-1 Abundance in Breast Cancer Cells.
De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics.
Potent carotenoid astaxanthin expands the anti-cancer activity of cisplatin in human prostate cancer cells.
The Valsa Mali effector Vm1G-1794 protects the aggregated MdEF-Tu from autophagic degradation to promote infection in apple.
Intrahippocampal injection of IL-1β upregulates Siah1-mediated degradation of synaptophysin by activation of the ERK signaling in male rat.
Apo- and holo-transferrin differentially interact with hephaestin and ferroportin in a novel mechanism of cellular iron release regulation.
Albumosomes formed by cytoplasmic pre-folding albumin maintain mitochondrial homeostasis and inhibit nonalcoholic fatty liver disease.
Cathepsin K promotes the proliferation of hepatocellular carcinoma cells through induction of SIAH1 ubiquitination and degradation.
Selenoprotein P deficiency protects against immobilization-induced muscle atrophy by suppressing atrophy-related E3 ubiquitin ligases.
ASPM promotes migration and invasion of anaplastic thyroid carcinoma by stabilizing KIF11.
Dexamethasone-stimulated glucocorticoid receptor signaling positively regulates the endoplasmic reticulum-associated degradation (ERAD) mechanism in hepatocellular carcinoma cells.
Complex metabolic disharmony in PMM2-CDG paves the way to new therapeutic approaches.
USP51 promotes non-small cell lung carcinoma cell stemness by deubiquitinating TWIST1.
Polyphyllin D punctures hypertrophic lysosomes to reverse drug resistance of hepatocellular carcinoma by targeting acid sphingomyelinase.
Kaempferol inhibits non-homologous end joining repair via regulating Ku80 stability in glioma cancer.
STUB1-mediated ubiquitination regulates the stability of GLUD1 in lung adenocarcinoma.
A novel variant in the FBP1 gene causes fructose-1,6-bisphosphatase deficiency through increased ubiquitination.
Combinations of ivermectin with proteasome inhibitors induce synergistic lethality in multiple myeloma.
CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization.
Multi-proteomic Analysis Revealed Distinct Protein Profiles in Cerebrospinal Fluid of Patients Between Anti-NMDAR Encephalitis NORSE and Cryptogenic NORSE.
Fzr regulates silk gland growth by promoting endoreplication and protein synthesis in the silkworm.
PD-L1 upregulation promotes drug-induced pulmonary fibrosis by inhibiting vimentin degradation.
PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms.
Ring domains are essential for GATOR2-dependent mTORC1 activation.
UCHL3 promotes cervical cancer development and metastasis by stabilizing NRF2 via deubiquitination.
Progesterone regulates the endoplasmic reticulum-associated degradation and Unfolded Protein Response axis by mimicking the androgenic stimulation in prostate cancer cells.
Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.
SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1.
mascRNA alleviates STING-TBK1 signaling-mediated immune response through promoting ubiquitination of STING.
Neocryptotanshinone protects against myocardial ischemia-reperfusion injury by promoting autolysosome degradation of protein aggregates via the ERK1/2-Nrf2-LAMP2 pathway.
RBX1 regulates PKM alternative splicing to facilitate anaplastic thyroid carcinoma metastasis and aerobic glycolysis by destroying the SMAR1/HDAC6 complex.
Rho A/ROCK1 signaling-mediated metabolic reprogramming of valvular interstitial cells toward Warburg effect accelerates aortic valve calcification via AMPK/RUNX2 axis.
UBE2E2 enhances Snail-mediated epithelial-mesenchymal transition and Nrf2-mediated antioxidant activity in ovarian cancer.
FSIP1 enhances the therapeutic sensitivity to CDK4/6 inhibitors in triple-negative breast cancer patients by activating the Nanog pathway.
USP10 promotes intrahepatic cholangiocarcinoma cell survival and stemness via SNAI1 deubiquitination.
Mutual regulation between TRIM21 and TRIM8 via K48-linked ubiquitination.
Hypoxia-sensing VGLL4 promotes LDHA-driven lactate production to ameliorate neuronal dysfunction in a cellular model relevant to Alzheimer's disease.
Exogenous H(2) S promotes ubiquitin-mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S-sulfhydration.
Stimulator of interferon genes promotes diabetic sarcopenia by targeting peroxisome proliferator activated receptors γ degradation and inhibiting fatty acid oxidation.
CoCl(2) -triggered pseudohypoxic stress induces proteasomal degradation of SIRT4 via polyubiquitination of lysines K78 and K299.
RNF125, transcriptionally regulated by NFATC2, alleviates osteoarthritis via inhibiting the Wnt/β-catenin signaling pathway through degrading TRIM14.
Sesamol serves as a p53 stabilizer to relieve rheumatoid arthritis progression and inhibits the growth of synovial organoids.
VAMP8 suppresses the metastasis via DDX5/β-catenin signal pathway in osteosarcoma.
E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC.
Salvianolic acid B ameliorates myocardial fibrosis in diabetic cardiomyopathy by deubiquitinating Smad7.
circRPS19 affects HK2‑mediated aerobic glycolysis and cell viability via the miR‑125a‑5p/USP7 pathway in gastric cancer.
The ubiquitin-specific protease 5 mediated deubiquitination of LSH links metabolic regulation of ferroptosis to hepatocellular carcinoma progression.
Wnt/β-Catenin Promotes the Osteoblastic Potential of BMP9 Through Down-Regulating Cyp26b1 in Mesenchymal Stem Cells.
O-GlcNAcylation enhances Reticulon 2 protein stability and its promotive effects on gastric cancer progression.
IRF5 promotes glycolysis in the progression of hepatocellular carcinoma and is regulated by TRIM35.
Liquiritigenin Confers Liver Protection by Enhancing NRF2 Signaling through Both Canonical and Non-canonical Signaling Pathways.
BDE209-promoted Dio2 degradation in H4 glioma cells through the autophagy pathway, resulting in hypothyroidism and leading to neurotoxicity.
Persistent activation of Nrf2 in a p62-dependent non-canonical manner aggravates lead-induced kidney injury by promoting apoptosis and inhibiting autophagy.
E3 ligase MAEA-mediated ubiquitination and degradation of PHD3 promotes glioblastoma progression.
CEBPB upregulates P4HA2 to promote the malignant biological behavior in IDH1 wildtype glioma.
Bone-targeted bortezomib increases bone formation within Calvarial trans-sutural distraction osteogenesis.
Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells.
SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions.
Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS.
Antitumoral effects of Bortezomib in malignant mesothelioma: evidence of mild endoplasmic reticulum stress in vitro and activation of T cell response in vivo.
IKZF1 selectively enhances homologous recombination repair by interacting with CtIP and USP7 in multiple myeloma.
Pantothenate Kinase 1 Inhibits the Progression of Hepatocellular Carcinoma by Negatively Regulating Wnt/β-catenin Signaling.
The lncRNA BDNF-AS/WDR5/FBXW7 axis mediates ferroptosis in gastric cancer peritoneal metastasis by regulating VDAC3 ubiquitination.
Deacetylation of Glutaminase by HDAC4 contributes to Lung Cancer Tumorigenesis.
PPDPF Promotes the Progression and acts as an Antiapoptotic Protein in Non-Small Cell Lung Cancer.
CHIP Decline Is Associated With Isoflurane-Induced Neurodegeneration in Aged Mice.
Nedd4-2 Haploinsufficiency in Mice Impairs the Ubiquitination of Rer1 and Increases the Susceptibility to Endoplasmic Reticulum Stress and Seizures.
Paeoniflorin directly binds to TNFR1 to regulate podocyte necroptosis in diabetic kidney disease.
Honokiol Inhibits HIF-1α-Mediated Glycolysis to Halt Breast Cancer Growth.
Dual Effects: Intrastriatal Injection of α-syn N103/tau N368 Preformed Fibrils Promotes Endogenous α-synuclein Aggregates in the Proximal Colon.
Hepatic RACK1 deficiency protects against fulminant hepatitis through myeloid-derived suppressor cells.
Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation.
Ring finger protein 128 promotes, rather than inhibits, colorectal cancer progression by regulating the Hippo signaling pathway.
Tubuloside B, isolated from Cistanche tubulosa, a promising agent against M1 macrophage activation via synergistically targeting Mob1 and ERK1/2.
The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells by encoding a novel protein NTRK2-243aa.
LINC01194 recruits NUMA1 to promote ubiquitination of RYR2 to enhance malignant progression in triple-negative breast cancer.
Capsaicin ameliorates diabetic retinopathy by inhibiting poldip2-induced oxidative stress.
Dihydroartemisinin suppresses renal fibrosis in mice by inhibiting DNA-methyltransferase 1 and increasing Klotho.
Linear ubiquitination of PTEN impairs its function to promote prostate cancer progression.
Bortezomib prodrug catalytic nanoreactor for chemo/chemodynamic therapy and macrophage re-education.
The HN1/HMGB1 axis promotes the proliferation and metastasis of hepatocellular carcinoma and attenuates the chemosensitivity to oxaliplatin.
Pyrogallol enhances therapeutic effect of human umbilical cord mesenchymal stem cells against LPS-mediated inflammation and lung injury via activation of Nrf2/HO-1 signaling.
The feedback loop of METTL14 and USP38 regulates cell migration, invasion and EMT as well as metastasis in bladder cancer.
Deletion of Smurf1 attenuates liver steatosis via stabilization of p53.
MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer.
ARHGEF3 regulates the stability of ACLY to promote the proliferation of lung cancer.
CGG repeat expansion in NOTCH2NLC causes mitochondrial dysfunction and progressive neurodegeneration in Drosophila model.
Capsaicin suppresses hepatocarcinogenesis by inhibiting the stemness of hepatic progenitor cells via SIRT1/SOX2 signaling pathway.
Identification of circular RNA BTBD7_hsa_circ_0000563 as a novel biomarker for coronary artery disease and the functional discovery of BTBD7_hsa_circ_0000563 based on peripheral blood mononuclear cells: a case control study.
14-3-3 proteins contribute to autophagy by modulating SINAT-mediated degradation of ATG13.
Hydrogen Sulfide Regulates SERCA2a Ubiquitylation via Muscle RING Finger-1 S-Sulfhydration to Affect Cardiac Contractility in db/db Mice.
Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis.
Ubiquitination regulates cytoophidium assembly in Schizosaccharomyces pombe.
UBE2L3 promotes squamous cell carcinoma progression in the oral cavity and hypopharynx via activating the NF-κB signaling by increasing IκBα degradation.
Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension.
CCDC50 suppresses NLRP3 inflammasome activity by mediating autophagic degradation of NLRP3.
Rho family GTPase 1 (RND1), a novel regulator of p53, enhances ferroptosis in glioblastoma.
Gamma frequency light flicker regulates amyloid precursor protein trafficking for reducing β-amyloid load in Alzheimer's disease model.
A novel protein encoded by circHNRNPU promotes multiple myeloma progression by regulating the bone marrow microenvironment and alternative splicing.
Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide.
Inhibition of USP7 suppresses advanced glycation end-induced cell cycle arrest and senescence of human umbilical vein endothelial cells through ubiquitination of p53.
lncRNA SNHG26 promoted the growth, metastasis, and cisplatin resistance of tongue squamous cell carcinoma through PGK1/Akt/mTOR signal pathway.
HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway.
GSK-3β inhibition elicits a neuroprotection by restoring lysosomal dysfunction in neurons via facilitation of TFEB nuclear translocation after ischemic stroke.
AAA-ATPase valosin-containing protein binds the transcription factor SREBP1 and promotes its proteolytic activation by rhomboid protease RHBDL4.
The role of NOTCH2NLC in Parkinson's disease: A clinical, neuroimaging, and pathological study.
Hsa_circ_0072309 enhances autophagy and TMZ sensitivity in glioblastoma.
Stress-induced epinephrine promotes epithelial-to-mesenchymal transition and stemness of CRC through the CEBPB/TRIM2/P53 axis.
Mistargeting of aggregation prone mitochondrial proteins activates a nucleus-mediated posttranscriptional quality control pathway in trypanosomes.
Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death.
A novel circular RNA confers trastuzumab resistance in human epidermal growth factor receptor 2-positive breast cancer through regulating ferroptosis.
Cyclo(-Phe-Phe) alleviates chick embryo liver injury via activating the Nrf2 pathway.
SNHG25 facilitates SNORA50C accumulation to stabilize HDAC1 in neuroblastoma cells.
Glutathione-responsive copper-disulfiram nanoparticles for enhanced tumor chemotherapy.
RNF2 promotes the progression of colon cancer by regulating ubiquitination and degradation of IRF4.
Choline-induced SLC5A7 impairs colorectal cancer growth by stabilizing p53 protein.
MF-094, a potent and selective USP30 inhibitor, accelerates diabetic wound healing by inhibiting the NLRP3 inflammasome.
Phosphorylation-Induced Ubiquitination and Degradation of PXR through CDK2-TRIM21 Axis.
Hemin enhances radiosensitivity of lung cancer cells through ferroptosis.
SPOCK1 promotes metastasis in pancreatic cancer via NF-κB-dependent epithelial-mesenchymal transition by interacting with IκB-α.
RNF6 promotes the migration and invasion of breast cancer by promoting the ubiquitination and degradation of MST1.
Ubiquitinated gasdermin D mediates arsenic-induced pyroptosis and hepatic insulin resistance in rat liver.
Splicing factor arginine/serine-rich 8 promotes multiple myeloma malignancy and bone lesion through alternative splicing of CACYBP and exosome-based cellular communication.
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy.
The dual role of p62 in ferroptosis of glioblastoma according to p53 status.
Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway.
The deubiquitinating enzyme USP20 regulates the stability of the MCL1 protein.
4EBP1 senses extracellular glucose deprivation and initiates cell death signaling in lung cancer.
Acetylation of Checkpoint suppressor 1 enhances its stability and promotes the progression of triple-negative breast cancer.
The SPATA2/CYLD pathway contributes to doxorubicin-induced cardiomyocyte ferroptosis via enhancing ferritinophagy.
The daily caloric restriction and alternate-day fasting ameliorated lipid dysregulation in type 2 diabetic mice by downregulating hepatic pescadillo 1.
E3 ubiquitin ligase NEURL3 promotes innate antiviral response through catalyzing K63-linked ubiquitination of IRF7.
Melatonin inhibits angiotensin II-induced atrial fibrillation through preventing degradation of Ang II Type I Receptor-Associated Protein (ATRAP).
Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation.
Pharmacological induction of AMFR increases functional EAAT2 oligomer levels and reduces epileptic seizures in mice.
GNIP1 functions both as a scaffold protein and an E3 ubiquitin ligase to regulate autophagy in lung cancer.
PGE(2) -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.
CRIP1 suppresses BBOX1-mediated carnitine metabolism to promote stemness in hepatocellular carcinoma.
A small molecule inhibitor of caspase-1 inhibits NLRP3 inflammasome activation and pyroptosis to alleviate gouty inflammation.
UBE4B promotes the development of lung adenocarcinoma by enhancing proliferation, migration and glycolysis via PP2A/AKT signaling.
Circular RNA MTCL1 promotes advanced laryngeal squamous cell carcinoma progression by inhibiting C1QBP ubiquitin degradation and mediating beta-catenin activation.
circFAM120B functions as a tumor suppressor in esophageal squamous cell carcinoma via the miR-661/PPM1L axis and the PKR/p38 MAPK/EMT pathway.
Proteasome 26S subunit, non-ATPase 1 (PSMD1) facilitated the progression of lung adenocarcinoma by the de-ubiquitination and stability of PTEN-induced kinase 1 (PINK1).
Golgi Phosphoprotein 3 Confers Radioresistance via Stabilizing EGFR in Lung Adenocarcinoma.
Nuclear Receptor Interacting Protein-2 Mediates the Stabilization and Activation of β-Catenin During Podocyte Injury.
Autophagy Regulates VDAC3 Ubiquitination by FBXW7 to Promote Erastin-Induced Ferroptosis in Acute Lymphoblastic Leukemia.
ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells.
UBC Mediated by SEPT6 Inhibited the Progression of Prostate Cancer.
Simultaneous silencing Aurora-A and UHRF1 inhibits colorectal cancer cell growth through regulating expression of DNMT1 and STAT1.
MAD2B-mediated cell cycle reentry of podocytes is involved in the pathogenesis of FSGS.
Pentamidine Inhibits Ovarian Cancer Cell Proliferation and Migration by Maintaining Stability of PTEN in vitro.
Deltex3 inhibits Epithelial Mesenchymal Transition in Papillary Thyroid Carcinoma via promoting ubiquitination of XRCC5 to regulate the AKT signal pathway.
Nogo-B receptor is required for stabilizing TGF-β type I receptor and promotes the TGF-β1-induced epithelial-to-mesenchymal transition of non-small cell lung cancer.
Tetrandrine Modulates Rheb-mTOR Signaling-Mediated Selective Autophagy and Protects Pulmonary Fibrosis.
Samotolisib Attenuates Acute Liver Injury Through Inhibiting Caspase-11-Mediated Pyroptosis Via Regulating E3 Ubiquitin Ligase Nedd4.
Autophagic Inhibition of Caveolin-1 by Compound Phyllanthus urinaria L. Activates Ubiquitination and Proteasome Degradation of β-catenin to Suppress Metastasis of Hepatitis B-Associated Hepatocellular Carcinoma.
Hepatitis B Surface Antigen Suppresses the Activation of Nuclear Factor Kappa B Pathway via Interaction With the TAK1-TAB2 Complex.
YY1-mediated reticulocalbin-2 upregulation promotes the hepatocellular carcinoma progression via activating MYC signaling.
TRIM50 Suppresses Pancreatic Cancer Progression and Reverses the Epithelial-Mesenchymal Transition via Facilitating the Ubiquitous Degradation of Snail1.
CDC20 promotes bone formation via APC/C dependent ubiquitination and degradation of p65.
Proteasome inhibition by bortezomib parallels a reduction in head and neck cancer cells growth, and an increase in tumor-infiltrating immune cells.
Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex.
Hydrogen sulphide reduced the accumulation of lipid droplets in cardiac tissues of db/db mice via Hrd1 S-sulfhydration.
Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy: Dynamic analysis on cytotoxic effects of LW-218.
Melatonin potentiates the cytotoxic effect of Neratinib in HER2(+) breast cancer through promoting endocytosis and lysosomal degradation of HER2.
NudCL2 is an autophagy receptor that mediates selective autophagic degradation of CP110 at mother centrioles to promote ciliogenesis.
DOC-2/DAB2 interactive protein destabilizes c-Myc to impair the growth and self-renewal of colon tumor-repopulating cells.
Efficacy and long-term safety of CRISPR/Cas9 genome editing in the SOD1-linked mouse models of ALS.
Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2/ARE axis.
Osteocrin, a novel myokine, prevents diabetic cardiomyopathy via restoring proteasomal activity.
PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53.
Nedd4-2 haploinsufficiency in mice causes increased seizure susceptibility and impaired Kir4.1 ubiquitination.
Gankyrin activates the hedgehog signalling to drive metastasis in osteosarcoma.
USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites.
Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/TfR1 pathway in the rat hearts after ischemia/reperfusion.
Baicalein suppresses growth of non-small cell lung carcinoma by targeting MAP4K3.
Polyglucosan body myopathy 1 may cause cognitive impairment: a case report from China.
Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice.
FV-429 induces autophagy blockage and lysosome-dependent cell death of T-cell malignancies via lysosomal dysregulation.
Dysregulation of USP18/FTO/PYCR1 signaling network promotes bladder cancer development and progression.
Role of the E3 ubiquitin ligase HRD1 in the regulation of serotonin transporter function.
FAT10 promotes the progression of bladder cancer by upregulating HK2 through the EGFR/AKT pathway.
SQSTM1/ p62 oligomerization contributes to Aβ-induced inhibition of Nrf2 signaling.
The novel ZEB1-upregulated protein PRTG induced by Helicobacter pylori infection promotes gastric carcinogenesis through the cGMP/PKG signaling pathway.
DUOX2 promotes the progression of colorectal cancer cells by regulating the AKT pathway and interacting with RPL3.
Upstream open reading frame with NOTCH2NLC GGC expansion generates polyglycine aggregates and disrupts nucleocytoplasmic transport: implications for polyglycine diseases.
Hsa_circ_0024093 accelerates VSMC proliferation via miR-4677-3p/miR-889-3p/USP9X/YAP1 axis in in vitro model of lower extremity ASO.
CCT8 recovers WTp53-suppressed cell cycle evolution and EMT to promote colorectal cancer progression.
USP3 promotes gastric cancer progression and metastasis by deubiquitination-dependent COL9A3/COL6A5 stabilisation.
Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling.
Increased AT(1) receptor expression mediates vasoconstriction leading to hypertension in Snx1(-/-) mice.
Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage.
Ubiquitin-dependent Argonauteprotein MEL1 degradation is essential for rice sporogenesis and phasiRNA target regulation.
Anaplasma phagocytophilum AptA enhances the UPS, autophagy, and anti-apoptosis of host cells by PSMG3.
Anti-tumor activity of a novel proteasome inhibitor D395 against multiple myeloma and its lower cardiotoxicity compared with carfilzomib.
Tauroursodeoxycholic acid attenuates cisplatin-induced ototoxicity by inhibiting the accumulation and aggregation of unfolded or misfolded proteins in the endoplasmic reticulum.
FBXL10 promotes ERRα protein stability and proliferation of breast cancer cells by enhancing the mono-ubiquitylation of ERRα.
Cancer Cell enters reversible quiescence through Intracellular Acidification to resist Paclitaxel Cytotoxicity.
Parkin interacts with Mitofilin to increase dopaminergic neuron death in response to Parkinson's disease-related stressors.
HDAC6, A Novel Cargo for Autophagic Clearance of Stress Granules, Mediates the Repression of the Type I Interferon Response During Coxsackievirus A16 Infection.
Ubiquitin E3 Ligase c-Cbl Is a Host Negative Regulator of Nef Protein of HIV-1.
SPOP attenuates migration and invasion of choriocarcinoma cells by promoting DHX9 degradation.
WDHD1 Leads to Cisplatin Resistance by Promoting MAPRE2 Ubiquitination in Lung Adenocarcinoma.
p53 Affects PGC1α Stability Through AKT/GSK-3β to Enhance Cisplatin Sensitivity in Non-Small Cell Lung Cancer.
Tobramycin suppresses HUWE1 degradation to control MCL-1 stability during tumour development.
Crosstalk between cardiomyocytes and noncardiomyocytes is essential to prevent cardiomyocyte apoptosis induced by proteasome inhibition.
The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models.
Involvement of p53 Acetylation in Growth Suppression of Cutaneous T-Cell Lymphomas Induced by HDAC Inhibition.
LINC00452 promotes ovarian carcinogenesis through increasing ROCK1 by sponging miR-501-3p and suppressing ubiquitin-mediated degradation.
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis.
SUMOylation Protects FASN Against Proteasomal Degradation in Breast Cancer Cells Treated with Grape Leaf Extract.
α-synuclein strains that cause distinct pathologies differentially inhibit proteasome.
Arabidopsis SINAT Proteins Control Autophagy by Mediating Ubiquitylation and Degradation of ATG13.
Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages.
A robust TDP-43 knock-in mouse model of ALS.
Voltage-gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation.
Lanosterol modulates proteostasis via dissolving cytosolic sequestosomes/aggresome-like induced structures.
Hydrogen sulfide regulates muscle RING finger-1 protein S-sulfhydration at Cys(44) to prevent cardiac structural damage in diabetic cardiomyopathy.
Down-Regulated CUEDC2 Increases GDNF Expression by Stabilizing CREB Through Reducing Its Ubiquitination in Glioma.
MAFG-AS1 promotes tumor progression via regulation of the HuR/PTBP1 axis in bladder urothelial carcinoma.
PHLDA1 promotes microglia-mediated neuroinflammation via regulating K63-linked ubiquitination of TRAF6.
Hydrogen sulphide ameliorating skeletal muscle atrophy in db/db mice via Muscle RING finger 1 S-sulfhydration.
Long non-coding RNA LOC100133669 promotes cell proliferation in oesophageal squamous cell carcinoma.
Exogenous H(2)S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.
Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6/TAK1/MAPK and Nrf2 Signaling Pathway.
The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein.
STAT3 Regulates the Type I IFN-Mediated Antiviral Response by Interfering with the Nuclear Entry of STAT1.
Long Noncoding RNA-DACH1 (Dachshund Homolog 1) Regulates Cardiac Function by Inhibiting SERCA2a (Sarcoplasmic Reticulum Calcium ATPase 2a).
Cinobufotalin powerfully reversed EBV-miR-BART22-induced cisplatin resistance via stimulating MAP2K4 to antagonize non-muscle myosin heavy chain IIA/glycogen synthase 3β/β-catenin signaling pathway.
Autophagy protects HUVECs against ER stress-mediated apoptosis under simulated microgravity.
The immunoproteasome catalytic β5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation.
Nilotinib: A Tyrosine Kinase Inhibitor Mediates Resistance to Intracellular Mycobacterium Via Regulating Autophagy.
The endogenous retrovirus-derived long noncoding RNA TROJAN promotes triple-negative breast cancer progression via ZMYND8 degradation.
THZ1 suppresses human non-small-cell lung cancer cells in vitro through interference with cancer metabolism.
Fludarabine as an Adjuvant Improves Newcastle Disease Virus-Mediated Antitumor Immunity in Hepatocellular Carcinoma.
Autosomal dominant mitochondrial membrane protein-associated neurodegeneration (MPAN).
TRIM28 protects CARM1 from proteasome-mediated degradation to prevent colorectal cancer metastasis.
Hsp90ab1 stabilizes LRP5 to promote epithelial-mesenchymal transition via activating of AKT and Wnt/β-catenin signaling pathways in gastric cancer progression.
YY1-regulated LINC00152 promotes triple negative breast cancer progression by affecting on stability of PTEN protein.
Kindlin-2 links mechano-environment to proline synthesis and tumor growth.
Downregulation of MUTYH contributes to cisplatin‑resistance of esophageal squamous cell carcinoma cells by promoting Twist‑mediated EMT.
USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication.
Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy.
Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice.
TRIM59 regulates autophagy through modulating both the transcription and the ubiquitination of BECN1.
M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole.
Pyk2 deficiency potentiates osteoblast differentiation and mineralizing activity in response to estrogen or raloxifene.
14-3-3ζ binds to hepatitis B virus protein X and maintains its protein stability in hepatocellular carcinoma cells.
Downregulation of glycine decarboxylase enhanced cofilin-mediated migration in hepatocellular carcinoma cells.
Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation.
Identification of Residues Controlling Restriction versus Enhancing Activities of IFITM Proteins on Entry of Human Coronaviruses.
CRISPR/Cas9-Targeted Deletion of Polyglutamine in Spinocerebellar Ataxia Type 3-Derived Induced Pluripotent Stem Cells.
Ubiquitin-Specific Protease USP6 Regulates the Stability of the c-Jun Protein.
SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer.
The N-terminal ubiquitin-associated domain of Cezanne is crucial for its function to suppress NF-κB pathway.
Temozolomide-perillyl alcohol conjugate downregulates O(6)-methylguanin DNA methltransferase via inducing ubiquitination-dependent proteolysis in non-small cell lung cancer.
The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma.
Role of the Ubiquitin C-Terminal Hydrolase L1-Modulated Ubiquitin Proteasome System in Auditory Cortex Senescence.
Endoplasmic Reticulum Stress Is Involved in Cochlear Cell Apoptosis in a Cisplatin-Induced Ototoxicity Rat Model.
HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway.
MDM2 Contributes to High Glucose-Induced Glomerular Mesangial Cell Proliferation and Extracellular Matrix Accumulation via Notch1.
Liposomal honokiol induced lysosomal degradation of Hsp90 client proteins and protective autophagy in both gefitinib-sensitive and gefitinib-resistant NSCLC cells.
Exogenous H(2)S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.
AMPK Serves as a Therapeutic Target Against Anemia of Inflammation.
A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer.
TRAF Family Proteins Regulate Autophagy Dynamics by Modulating AUTOPHAGY PROTEIN6 Stability in Arabidopsis.
A novel glutaminase inhibitor-968 inhibits the migration and proliferation of non-small cell lung cancer cells by targeting EGFR/ERK signaling pathway.
The N-Terminal of Aquareovirus NS80 Is Required for Interacting with Viral Proteins and Viral Replication.
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness.
Far-infrared promotes burn wound healing by suppressing NLRP3 inflammasome caused by enhanced autophagy.
Nogo-B receptor promotes the chemoresistance of human hepatocellular carcinoma via the ubiquitination of p53 protein.
Proteomic analysis of apoptosis induction by lariciresinol in human HepG2 cells.
The Ubiquitin-like Protein FAT10 Stabilizes eEF1A1 Expression to Promote Tumor Proliferation in a Complex Manner.
Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon.
The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.
DEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase.
The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer.
Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins.
Rock2 promotes the invasion and metastasis of hepatocellular carcinoma by modifying MMP2 ubiquitination and degradation.
Clinicopathologic report of ocular involvement in ALS patients with C9orf72 mutation.
Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility.
Ubiquitin B in cervical cancer: critical for the maintenance of cancer stem-like cell characters.
Downregulation of the ubiquitin-proteasome system in normal colonic macrophages and reinduction in inflammatory bowel disease.
Amyloid precursor protein accumulates in aggresomes in response to proteasome inhibitor.
Guo X, Lin Y, Jiang Y, Wang M, Li Y, Gao Y, Chen B, Bao Z, Tian H, Chu X, Zhang Z, Shao J, Zhang F, Wang H, Xuan J, Xu X, Zheng S
International journal of biological sciences 2026;22(3):1648-1673
International journal of biological sciences 2026;22(3):1648-1673
NEDD4 promotes reactive astrogliosis by enhancing K63-linked ubiquitination and inhibiting chaperone-mediated autophagy degradation of YAP1.
Ye W, Li Y, Wang W, Pan D, Wang X, Gu Y, Zhu Y, Wang H, Lu X, Jiang D, Tang P, Shu H, Ma J, Cai W
International journal of biological sciences 2026;22(2):858-875
International journal of biological sciences 2026;22(2):858-875
Potential Anti-Cancer Drug 6RK73 Suppresses Ovarian Cancer Growth by Inactivating the AKT1/Sp1 Induced c-Myc Signaling Pathway.
Kuang S, Feng W, He S, Meng W, Yang C, Ning Y
Journal of Cancer 2026;17(2):245-256
Journal of Cancer 2026;17(2):245-256
Curcumin enhances GSDME-mediated pyroptosis to potentiate PD-1/PD-L1 immune checkpoint blockade in colorectal cancer.
Tan D, Li G, Li X, Zhai W, Jing L
Frontiers in pharmacology 2026;17:1734653
Frontiers in pharmacology 2026;17:1734653
PLK1 stabilizes β-catenin to drive colorectal carcinogenesis through NFKB2-mediated transcriptional activation of USP2a and site-specific phosphorylation.
Li Y, Zhao L, Deng J, Lu S, Du J, Chen C, Zhao L, Xu Z, Wang W, Wang Y, Zou F
Theranostics 2026;16(7):3488-3506
Theranostics 2026;16(7):3488-3506
BPGM as an intrinsic brake to constrain metastasis through phospho-epigenetic-mediated carnitine biosynthesis suppression.
Wu MZ, Feng D, Liu WP, Huang WL, Wu Q, Chou TS, Xiao WH, Yao ZZ, Li ZJ, Xie TT, Chen CH, Yang ZY, Mao RW, Wu CC, Wang JC, Zhang YJ, Kellems RE, Xia Y
Neoplasia (New York, N.Y.) 2026 May;75:101299
Neoplasia (New York, N.Y.) 2026 May;75:101299
RNF220 mediates K63-linked polyubiquitination of STAT3 and aggravates pathological cardiac hypertrophy.
Gao Y, Zhao Z, Chen X, Li N, Li Y, Guan J, Dai H
Cell death and differentiation 2026 May;33(5):945-958
Cell death and differentiation 2026 May;33(5):945-958
SIRT3 promotes oxaliplatin sensitivity in hepatocellular carcinoma by promoting ferroptosis through endoplasmic reticulum stress response.
Xu Y, Ma C, Xu X, Tu J, Chen X, Yang X, Sun D, Liu S, Wan Y, Qin L, Gu W, Qian H
Pathology, research and practice 2026 May;281:156400
Pathology, research and practice 2026 May;281:156400
USP18 mediates high glucose-induced cardiomyocyte injury by regulating the JAK/STAT signaling pathway through stabilizing FOXC2 expression.
Xu Z, Ren W, Gu J, Deng W, Zuo L
Journal of diabetes investigation 2026 May;17(5):729-738
Journal of diabetes investigation 2026 May;17(5):729-738
Curcumin augments mitophagy via Nrf2-PINK1-mediated, Parkin-dependent ubiquitination to suppress ferroptosis in post-cardiac arrest brain injury.
Li Z, Xu W, Ren S, Zheng Q, Xing J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158035
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158035
NUP62 promotes breast cancer progression and inhibits ferroptosis by stabilizing NRF2 in a KEAP1-dependent way.
Qiu Z, Lin Y, Chen S, Cao W, Yang J, Li R, Chen Y, Yao X, Fu S, Jin N
iScience 2026 May 15;29(5):115484
iScience 2026 May 15;29(5):115484
Phenylephrine attenuates LPS-induced lung injury via Foxh1/GSK-3β/β-catenin-mediated alveolar epithelial cell differentiation in ARDS.
Zeng Z, Yin Y, Cong Z, Wei S, Wei X, Shen Z, Ge Q, Zhu X
International immunopharmacology 2026 May 15;177:116541
International immunopharmacology 2026 May 15;177:116541
TRIM24-mediated K27-linked ubiquitination of ULK1 alleviates energy stress-induced autophagy and promote prostate cancer growth in the context of SPOP mutation.
Chen S, Lin J, Yang Z, Wang Y, Wang Q, Wang D, Qu Y, Lin Q, Liu J, Yan S, Wang Z, Qian X, Xiao Y, Li X, Chen Y, Fang W, Zhao J, Lu Z, Ren H, Zhu Y, Ma L
Cell death and differentiation 2026 Mar;33(3):480-495
Cell death and differentiation 2026 Mar;33(3):480-495
Hypoxia-inducible factor 1αa regulates lipid metabolism to coordinate adipocyte hypertrophy and hyperplasia in grass carp.
Wei M, Tian Z, Song L, Xue R, Li H, Ji H, Sun J
The Journal of biological chemistry 2026 Mar;302(3):111195
The Journal of biological chemistry 2026 Mar;302(3):111195
Restricting intracellular Salmonella proliferation by coordinating p-TBK1 mediated mitophagy and xenophagy.
Li J, Yang Y, Ge Y, Zhang X, Liu H, Chen Y, Yang Y, Wu Z
Autophagy 2026 Mar;22(3):445-467
Autophagy 2026 Mar;22(3):445-467
Inhibition of PGK1 enhances sensitivity to tyrosine kinase inhibitor in T315I-mutant leukemia.
Wang H, Jiang F, Pan A, Jin C, Xue Y, Liu W, Gu R, Zhou Y, Shen Q, Ma T, Yu X
Acta pharmaceutica Sinica. B 2026 Mar;16(3):1449-1465
Acta pharmaceutica Sinica. B 2026 Mar;16(3):1449-1465
YTHDF3-TRIM2-P53 axis promotes malignant progression in uveal melanoma (UVM).
Li H, Chen Y, Chen W, Li D, Hao R, Zhang W
Cellular signalling 2026 Mar;139:112316
Cellular signalling 2026 Mar;139:112316
Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome-Mediated Colitis and Mood Disorder.
Gai W, Wu M, Wu A, Jing Z, Ye Z, Jin J, Zhang Y, Zhao M, Liu G, Wang X, Yang X, Dong J, Xu Y, Zhang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(16):e05906
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(16):e05906
CircIQGAP1-CARM1 axis promotes renal cell carcinoma progression through glycolytic reprogramming.
Jia R, Zou B, Liang Y, Chen Q, Chen T, Li X, Zhang C, Pei F, Zhu X, Bian J, Guo R
Cell death & disease 2026 Mar 27;17(1)
Cell death & disease 2026 Mar 27;17(1)
Downregulation of B7-H4 contributes to the synergistic effect of USP2a-targeted/anti-PD-1 combination therapy in EGFR mutant lung cancer.
Sun B, Kong M, Jiang X, Zhu L, Zhang J, Tan L, Wang C, Yuan Z, Chen S, Wang C, Jiang Y, Zhang L
Cancer immunology, immunotherapy : CII 2026 Mar 26;75(4)
Cancer immunology, immunotherapy : CII 2026 Mar 26;75(4)
Design and Synthesis of Pyrrolo[3,4-d]pyrimidine-Based ATR Degraders for Effective Treatment of Colorectal Cancer in Mouse Model.
Mao ND, Hui Z, Wang CC, He ML, Li SR, Yu MQ, Ye L, Zhou JW, Wang ZH, Du BQ, Ye GW, Zhang YQ, Yao X, Feng XL, Lirussi F, Garrido C, Gao Y, Luo H, Ye XY
Journal of medicinal chemistry 2026 Mar 26;69(6):6902-6928
Journal of medicinal chemistry 2026 Mar 26;69(6):6902-6928
Stigmasterol upregulates Akt/mTOR/p70S6K signaling through SYVN1 to alleviate osteoporosis in ovariectomized rats.
Zhu F, Li W, Cao Y, Dai B, Wu H, Zhu Y, Liu H
European journal of nutrition 2026 Mar 26;65(3)
European journal of nutrition 2026 Mar 26;65(3)
Cannabidiol attenuates the LPS/D-Galactosamine-induced acute liver injury by inhibiting parkin-mediated ubiquitination of MFN2.
Zhan Z, Jiang Y, Chen S, Yang Q, Pan G, Liu Y, Fang W, Chen R, Tang L, Lin C
Journal of ethnopharmacology 2026 Mar 25;359:121067
Journal of ethnopharmacology 2026 Mar 25;359:121067
CDH4/UBA1/RBMX axis promotes polycystic ovary syndrome progression through YAP1 activation.
Xu N, Yu B, Li Y, Yang Y, Wang Y, Fang L, Wu H, Luan Y, Yin C
Cellular & molecular biology letters 2026 Mar 25;31(1)
Cellular & molecular biology letters 2026 Mar 25;31(1)
FAM83D facilitates EMT and metastasis of cervical cancer via interaction with GSK3β and inactivation of GSK3β/stabilization of Snail signaling.
Li J, Li F, Meng X, Yang Z, Li Z, Tang H, Zhu W, Li H, He X, Lin X, Han Z, Chen M, Yang Y, Wang J, Zhang K
Biology direct 2026 Mar 25;21(1)
Biology direct 2026 Mar 25;21(1)
USP5-mediated CD73 deubiquitination drives osimertinib resistance via PI3K/AKT and glycolysis activation in LUAD.
Chen R, Han XH, Zhang Z, Han XJ, Xie J
iScience 2026 Mar 20;29(3):114916
iScience 2026 Mar 20;29(3):114916
UBA1 promotes cardiac hypertrophy by suppressing autophagy via targeting ATG5 for ubiquitination.
Lin QY, Yu WJ, Li JX, Jiang WX, Liu SJ, Bi HL, Li HH
Cell communication and signaling : CCS 2026 Mar 2;24(1)
Cell communication and signaling : CCS 2026 Mar 2;24(1)
Deubiquitination and stabilization of EIF4A3 by OTUB2 contributes to TPI1-mediated glycolysis and TNBC progression.
Wang Z, Chen X, Han X, Cao X, Wang X
Breast cancer research : BCR 2026 Mar 19;28(1)
Breast cancer research : BCR 2026 Mar 19;28(1)
UBE2M promotes malignant phenotypes of prostate cancer through mediating NAA10 neddylation.
Wang Q, Zhang J, Lin X, Shi R, Pan C, Hu Q, Xu L, Chen Q, Xue D, Yin J, Fu Q, Huang S
Journal of translational medicine 2026 Mar 19;24(1)
Journal of translational medicine 2026 Mar 19;24(1)
Lipotoxic hepatocyte-derived UBQLN1-enriched small extracellular vesicles activate hepatic stellate cells to promote hepatic fibrosis.
Yang F, Chen Y, Wang Y, Zheng G, Abouelnazar F, Fan L, Wang Y, Yan Y
Autophagy 2026 Mar 13;:1-23
Autophagy 2026 Mar 13;:1-23
Inhibition of ZBTB7B-mediated ADPGK transcription by NEDD4 impedes glycolysis and progression of lung adenocarcinoma.
Liu FP, Huang T, Yang HY, Zha JH, Xu C, Qiu CP, Wang X, Lu Z, Wang T
Oncogenesis 2026 Mar 11;15(1)
Oncogenesis 2026 Mar 11;15(1)
Suppression of LRRC41-mediated oncogenicity in hepatocellular carcinoma via USP7-targeted small molecule inhibitors.
Huang Y, Xi Y, Nie H, Wang Y, Hu J, Gao Y, Li J, Ma Y, Chu J, Tu L, Huang D, Cheng L
British journal of cancer 2026 Jun;134(11):1658-1670
British journal of cancer 2026 Jun;134(11):1658-1670
Semaglutide ameliorates aortic endothelial cell dysfunction in sarcopenia through the SIRT1/cGAS-STING signaling axis.
Liu Y, Sun W, Huang Z, Qiao G, Tang L, Huang T, Wang X, Li L, Zhang X, Ye X, Yang P, Wu H
Free radical biology & medicine 2026 Jul;250:352-369
Free radical biology & medicine 2026 Jul;250:352-369
Endothelial cells sense temozolomide resistance to facilitate monocyte-derived macrophage infiltration in glioblastoma.
Gao W, Huang J, Deng K, Lin X, Long X, Li X, Huang M, Wang X, She X, Liu Q, Wu M
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2026 Jan;84:101329
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2026 Jan;84:101329
MG53 protects against septic cardiac dysfunction by ubiquitinating ATF2.
Tian M, Shi Y, Gong X, Tan W, Guo X, Chen Y, Yang P, Ren H, Cai Q, Ma J, Zeng C, Wu G
Journal of advanced research 2026 Jan;79:263-275
Journal of advanced research 2026 Jan;79:263-275
HERC4 downregulates KRT19 to promote lung adenocarcinoma, migration, invasion and EMT.
Sun HJ, Peng MH, Feng ZY, Fu H, Liu XW
Translational oncology 2026 Jan;63:102593
Translational oncology 2026 Jan;63:102593
SLC7A5-ERBB2 axis drives olaparib resistance via de novo lipid synthesis in ovarian cancer.
Liu S, He Y, Ning X, Xu W, Hu X, Qin L, Yang Y, Chen X, Ma R
Oncogene 2026 Jan;45(2):140-263
Oncogene 2026 Jan;45(2):140-263
E3 ubiquitin ligase TRIM47 promotes intrahepatic cholangiocarcinoma progression by ubiquitinating fumarate hydratase and modulating macrophage polarization.
Fu Y, Wu J, Shi J, Jia C
The Journal of biological chemistry 2026 Jan;302(1):111035
The Journal of biological chemistry 2026 Jan;302(1):111035
Bushen Huoxue formula component β-Estradiol 3-acetate treats osteoarthritis through enhancing the TLR4 ubiquitination.
Liu X, Wang S, Kuang C, Deng Y, Yuan S, Zou J
The Journal of steroid biochemistry and molecular biology 2026 Jan;255:106862
The Journal of steroid biochemistry and molecular biology 2026 Jan;255:106862
Erbin destabilization by O-GlcNAcylation promotes 5-FU resistance via homologous recombination activation in colorectal cancer.
Zhang J, Liu C, Tang Y, Gao K, Xu W, Zhang J, Zhao L, Wang G
Biochemical pharmacology 2026 Jan;243(Pt 1):117400
Biochemical pharmacology 2026 Jan;243(Pt 1):117400
PIM1 protects pancreatic ductal cancer cells from glucose deprivation-induced oxidative stress via OXR1 phosphorylation.
Wang J, Yu W, Cai S, Wei H, Peng B, Qian J, Chen Y, Zheng F, Jiang H, Xie Q, Zhou H, Fang H, Lyu J
Biochimica et biophysica acta. Molecular basis of disease 2026 Jan;1872(1):168031
Biochimica et biophysica acta. Molecular basis of disease 2026 Jan;1872(1):168031
CypA Mediates Non-Small Cell Lung Cancer Chemoresistance by Attenuating Ferroptosis via Stabilizing SLC7A11.
Wang Z, Li A, Song Z, Liu X, Ge Y, Chen Z, Liu Y, Zhang B, Zhang H, Lan T
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(4):e11947
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(4):e11947
REEP1 Accumulation Disrupts ER Integrity and Drives Spinal Motoneuron Degeneration in Distal Hereditary Motor Neuropathy.
Bock A, Schurig M, Willoughby M, Mirecki A, Seemann E, Lohachova K, Katona I, Mittag S, Liebmann L, Franzka P, Heidari Horestani M, Khundadze M, Mosler T, Louie T, de Visser M, Weterman MAJ, Kiehntopf M, Beetz C, Nietzsche S, Huber O, Weis J, Kessels MM, Bhaskara RM, Qualmann B, Đikić I, Hübner CA
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(2):e11483
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(2):e11483
USP11-PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA-cGAS-STING Pathway After Intracerebral Hemorrhage.
He J, Qin Z, Cai Y, Liu H, Wang T, Hu Q, Xu Y, Yang P, Wu X, Qu Y, Guo W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e14283
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e14283
Type II Alveolar Epithelial Cells Promote Sepsis-Induced Immunosuppression in Alveolar Macrophages via Exosomal lncRNA Rmrp Release.
Liu C, Xuan W, Cao S, Jia H, Wu Q, Tan X, Wang Q, Li X, Ding L, Xiong Y, Zhao M, Zheng L, Xi Y, Tan J, Li R, Zhang X, Liu W, Wu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e00376
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e00376
Targeting VCP with V8 suppresses glioblastoma development via formation of aggregates and disruption of mitophagy flux.
Cao X, Li Y, Guo B, Liu Y, Wang B, Wang H, Lu J, Wei L, Gao Y, Guo Y, Wu T
Cellular oncology (Dordrecht, Netherlands) 2026 Jan 8;49(1):21
Cellular oncology (Dordrecht, Netherlands) 2026 Jan 8;49(1):21
TGF-β1/SMAD signaling downregulates KLF4 expression via direct transcriptional suppression and FAT10-mediated proteasomal degradation in hepatocellular carcinoma.
Chen Z, Zhao S, Chen D, Lou Y, Lu H, Yao Q, Lu J, Sun H
Cell & bioscience 2026 Jan 6;16(1):15
Cell & bioscience 2026 Jan 6;16(1):15
USP5 inhibition stimulates immunogenic ferroptosis that enhances immunotherapy in diffuse large B-cell lymphoma.
Wu J, Liu C, Chen Q, Deng Y, Wang J, Gao Y, Wei B
Cell communication and signaling : CCS 2026 Jan 5;24(1):93
Cell communication and signaling : CCS 2026 Jan 5;24(1):93
Indirect ubiquitination independent of endogenous ubiquitination machinery for targeted protein degradation.
Furuhata T, Yoshida K, Fujita R, Miyamoto J, Moriyama C, Masuda-Ozawa T, Tsuchiya H, Saeki Y, Okamoto A
Communications chemistry 2026 Jan 29;9(1):52
Communications chemistry 2026 Jan 29;9(1):52
MYC-driven TRIM27 upregulation promotes prostate cancer progression by enhancing CANX ubiquitination and activating PI3K/AKT signaling.
Wang Z, Ning J, Xu L, Cheng F
Functional & integrative genomics 2026 Jan 20;26(1):29
Functional & integrative genomics 2026 Jan 20;26(1):29
Intravesical instillation of pirfenidone/polydopamine nanoparticles for managing neurogenic bladder post-spinal cord injury by alleviating bladder inflammation and fibrosis.
Zhang J, Li H, Zhang L, Lv L, Zang M, Wang X, Wang S, Chen L, Yang Z, Yang L, Zhao J, Gao X, Guo D, Shi B, Zhang Z, Li Y
Journal of nanobiotechnology 2026 Jan 17;24(1):154
Journal of nanobiotechnology 2026 Jan 17;24(1):154
MCM8 promotes colorectal cancer progression by competitively inhibiting HRD1-mediated CDC42 ubiquitination and degradation.
Qian S, Zeng L, Chen F, Tian Y, Zhao B, Liu Q, Zhang B
Journal of translational medicine 2026 Jan 16;24(1)
Journal of translational medicine 2026 Jan 16;24(1)
The ER membrane protein complex acts as a chaperone to promote the biogenesis of multi-bundle membrane proteins.
Stanton M, Singal B, Biswal M, Agarwal M, Scheuing CE, Vargas GD, Gao A, Gifford CA, Pleiner T
bioRxiv : the preprint server for biology 2026 Jan 15;
bioRxiv : the preprint server for biology 2026 Jan 15;
Upregulated ARMCX1 suppresses nasopharyngeal carcinoma progression by promoting TRIM21-mediated β-catenin degradation.
Hu Z, Zhuo E, Guo J, Wu Y, Sun X, Qiu H, Zhou Y, Tan X, Zhang X
Cellular oncology (Dordrecht, Netherlands) 2026 Jan 14;49(1):25
Cellular oncology (Dordrecht, Netherlands) 2026 Jan 14;49(1):25
ASF1B promotes gastric cancer liver metastasis through inhibiting ZDHHC9/PCBP1/ SLC7A11 signaling axis mediated ferroptosis.
Wang M, Yu K, Ma M, Li J, Zhang Y, Ke Z, Wang H, Li Y
NPJ precision oncology 2026 Jan 14;10(1):66
NPJ precision oncology 2026 Jan 14;10(1):66
G3BP2 facilitates abnormal activation of fibroblast-like synoviocytes through p53 signaling pathway in rheumatoid arthritis.
Wu Q, Qin Y, Chen Y, Cheng N, Hu Z, Zheng Y, Wei X, Zhang W, Fang Y, Zhao Y, Zhou R, Hu W, Yao F
International immunopharmacology 2026 Jan 1;168(Pt 2):115961
International immunopharmacology 2026 Jan 1;168(Pt 2):115961
LAMA4, regulated by the transcription factor SP1 or the ubiquitin ligase NEDD4, mediates HUVEC dysfunction under hypoxia/reoxygenation conditions.
Zhang W, Lu D
Cytotechnology 2026 Feb;78(1):4
Cytotechnology 2026 Feb;78(1):4
Spatiotemporally controlled ferritin-targeting PROTAC nanoplatform for visualized manipulation of endogenous "Iron pool" in pancreatic cancer therapy.
Yang X, Luo W, Wang Y, Lu Y, Yu J, Liu C, Wang W, Du Y, Yu R
Materials today. Bio 2026 Feb;36:102661
Materials today. Bio 2026 Feb;36:102661
A novel lncRNA, lncMCL1, modulates neural pyroptosis associated with epilepsy via stabilizing DDX3X.
Wang H, Wu L, Liu C, Zhao X, Cui L, Gao J, Zhang C, Du T, Shi L, Ji Y, Xiao Y, Zhang J, Tu W, Meng F, Han C
Cell death and differentiation 2026 Feb;33(2):374-391
Cell death and differentiation 2026 Feb;33(2):374-391
Activation of mitophagy antagonizes high uric acid-induced hepatic lipid accumulation.
Chen J, Zhao H, Xi Y, Fu S, Xie D, Yu L, Wang Q, Chen B, Zhang Q, Zhang M, Ye X, Wu M, Que W, Chen S, Liu Y, Yamamoto T, Koyama H, Zhao H, Cheng J
The Journal of biological chemistry 2026 Feb;302(2):111054
The Journal of biological chemistry 2026 Feb;302(2):111054
Progressive rod bipolar cell loss, ubiquitin accumulation, and subretinal drusenoid deposits in Cln3Δex7/8 mice: New insights into juvenile neuronal ceroid lipofuscinosis pathogenesis.
Torsti T, Tamminen T, Toropainen E, Jalkanen A, Kauppinen A, Kaarniranta K, Forsberg MM
Experimental eye research 2026 Feb;263:110766
Experimental eye research 2026 Feb;263:110766
Reduced Proteasome Degradation of HSF-1 Shifts Protein Stress Management With Age in Caenorhabditis elegans.
Wang H, Sun F, He Z, Wang X, Liu H, Song M, Chen Q, Li Z, Wu L, Yan X, Zhu X, Shen Y
Aging cell 2026 Feb;25(2):e70399
Aging cell 2026 Feb;25(2):e70399
The UBC/SIRT5/DRP1 axis regulates mitochondrial dynamics to alleviate Staphylococcus aureus-induced oxidative stress and senescence in bovine mammary epithelial cells.
Hu H, Jiang N, Liu J, Bi J, Liu X, Xu B, Cao Y, Guo W, Fu S
PLoS pathogens 2026 Feb;22(2):e1013975
PLoS pathogens 2026 Feb;22(2):e1013975
CHB-Induced Immune Zonation Chaos Elicited LXRα-mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation.
Shi J, Li Q, Li J, Bai J, Xi J, He Q, Zhou J, Wang X, Song X, Li X, Yue X, Zhang X, Sun Z, Li J, Yang W, Cui Y, Shu W, Guo L, Wang S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e10275
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e10275
SREBF2 enhances lipid metabolism and represses anti-tumor immune responses in cervical cancer by increasing ACAT2.
Zhang Y, Shao Y, Li X, Zhou D, Zhou J, Yan Q, Gao W, Yang L
Communications biology 2026 Feb 7;9(1)
Communications biology 2026 Feb 7;9(1)
The GFPT2/O-GlcNAcylation/c-Myc axis promotes bladder cancer progression.
Xie H, Liao T, Tang H, Ban C, Cheng Z, Liao K, Li Y, Wei W, Zhou L, Yi X
Journal of translational medicine 2026 Feb 7;24(1)
Journal of translational medicine 2026 Feb 7;24(1)
PyHAT5 regulates anthocyanin biosynthesis in red-fleshed pear and undergoes ubiquitination and degradation by PyAIP2.
Chen G, Liu Y, Li J, Lin-Wang K, Espley RV, Brewer L, Allan AC, Yang G, Wei W, Zhao Y, Xue Z, Wu J
Plant physiology 2026 Feb 6;200(2)
Plant physiology 2026 Feb 6;200(2)
Wogonin derivative V8 enhances bortezomib efficacy in gastric carcinoma by disrupting lysosome-mediated drug resistance.
Li SC, Shao SZ, Zhang YH, Zhou Y, Shang WT, Gao Y, He QB, Guo QL, Guo CY, Zhang XB
World journal of gastroenterology 2026 Feb 28;32(8):113299
World journal of gastroenterology 2026 Feb 28;32(8):113299
A peptide immunomodulator activates MST1 to expand and stabilize murine and human regulatory T cells for immune tolerance.
Wang Y, Liu X, Li X, Zhao L, Chen H, Gong X, Xu J, Zhang J, Liu Z, Sun Y
Science translational medicine 2026 Feb 25;18(838):eadz0672
Science translational medicine 2026 Feb 25;18(838):eadz0672
Anti-Protein-Adsorption Nano-Proteolysis Targeting Chimeras as a Potent Platform for Efficient Programmed Cell Death Ligand 1 Degradation.
Lu X, Song S, Qiu F, Zhang H, Shi J, Wang B
ACS nano 2026 Feb 24;20(7):6110-6124
ACS nano 2026 Feb 24;20(7):6110-6124
TIGAR maintains intestinal epithelial regeneration by stabilizing HMGCL and promoting β-catenin β-hydroxybutyrylation in burn-induced sepsis.
Zhang P, Wu D, Wei Y, Su S, Zha X, Liu X, Zhang T, Huang Q, Chen Q, Bao Z, Fan S, Xia L, Peng X
Cell death & disease 2026 Feb 19;17(1)
Cell death & disease 2026 Feb 19;17(1)
CircRNA-TMEM71 Inhibits Human Aortic Smooth Muscle Cell Ferroptosis and Prevents Aortic Dissection Formation Through IGF2BP3-Mediated Stability of FSP1.
Zhu L, He C, Shi H, Shao G, Sun L
Journal of the American Heart Association 2026 Feb 17;15(4):e043108
Journal of the American Heart Association 2026 Feb 17;15(4):e043108
KIF20A inhibits TRIM21-dependent ubiquitination of DHX9 to boost SOX2 stability, enhancing OSCC stemness and ferroptosis resistance.
Zhang Z, Li Y, Hu J, Tang X, Li Z, Sun X, Feng D, Yao Y, Mao C, Tao Y, Xie L, Luo H, Li Y, Yu X, Peng X, Cong L, Jiang Y
Cell death & disease 2026 Feb 11;17(1):218
Cell death & disease 2026 Feb 11;17(1):218
Stabilization of IQGAP1 by the mTORC2 component PRR5 mediates mitogenic LINC01133-to-ERK signaling in triple-negative breast cancer.
Tu Z, Moses L, Hu Y, Sapkota S, Quintana LM, Guerrero L, Bell GW, Karnoub AE
Science signaling 2026 Feb 10;19(924):eadr4063
Science signaling 2026 Feb 10;19(924):eadr4063
USP14-mediated inhibition of CDH11 ubiquitination propels IL-1β-induced chondrocyte injury.
Hu K, Li J, Xia C, Gan K
Clinical rheumatology 2026 Apr;45(4):2401-2411
Clinical rheumatology 2026 Apr;45(4):2401-2411
Non-classic deubiquitinase USP13 inhibits bladder cancer metastasis through destabilizing cytoplasmic KDM3A.
Hu H, Zhan X, Xiong Y, Yuan R, Du Y, Dong Q, Li S, Guo B, Li Z, Feng J, Xiong S, Xiong J, Li D, Fu B, Xu S, Guo J
Oncogene 2026 Apr;45(15):1324-1337
Oncogene 2026 Apr;45(15):1324-1337
Core fucosylation of NCEH1 by FUT8 promotes progression of high-grade serous ovarian cancer by driving tumor-associated macrophage M2 polarization.
Pei X, Wang F, Liu X, Lei Y, Chen Y, Liu B, Sun R, Li P, Bi J, Liu S
Oncogene 2026 Apr;45(12):1128-1144
Oncogene 2026 Apr;45(12):1128-1144
Nanomagnetic Hyperthermia Sensitizes Gemcitabine Chemosensitivity in Pancreatic Cancer by Inhibiting HSPB1 to Amplify ACSL4-Mediated Ferroptosis.
Ren J, Wu S, Su T, Li H, Ding J, Chen F, Mo J, Li J, Wang Z, Han L, Wu Z
Small (Weinheim an der Bergstrasse, Germany) 2026 Apr;22(22):e14973
Small (Weinheim an der Bergstrasse, Germany) 2026 Apr;22(22):e14973
CircRNA0052011 modulates DNA damage and repair via FEN1 ubiquitination to mitigate polystyrene nanoplastics-induced genotoxicity in the lung.
Lan M, Zhong C, Xu X, He M, Fan L, Lu W, Qiu L, Fang J, Wang J, Wang S, Deng Z, Chen Y, Qiu L, Chen X, Jiang Y, Zhou Y
Environment international 2026 Apr;210:110211
Environment international 2026 Apr;210:110211
A Novel GmSIN1-GmRNF1a-GmCSN5a Module Determines Soybean Salt Tolerance and Yield Under Saline Soil Conditions.
Xu J, Shan M, Yang X, Zhao R, Zhang M, Bao G, Wang L, Li M, Zhi W, Wang M, Liu T, Zheng X, Zheng W, Lu Q, Li S, Xiang F
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(21):e74216
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(21):e74216
Citrulline Modulates Milk Fat Metabolism via the RTN3-FABP5 Axis in Bovine Mammary Epithelial Cells.
Cheng J, Ren K, Shi Y, Wang L, Li L, Yang Y, Kuang T, Pan S
Journal of agricultural and food chemistry 2026 Apr 8;74(13):11079-11091
Journal of agricultural and food chemistry 2026 Apr 8;74(13):11079-11091
Erianin facilitates pyroptosis in endometrial cancer via targeting m6A reader YTHDF1.
Shu W, Zhou X, Zhao R, Dong K, Shen X, Chen G, Cheng S, Zhang Q, Zhou T, Zhang J, Zhang T, Yu S, Li H, Yao Y, Liu Y, Zhang J, Wang H
Chinese medicine 2026 Apr 7;21(1)
Chinese medicine 2026 Apr 7;21(1)
HAO2 inhibits the growth and lipid metabolism of head and neck squamous cell carcinoma by enhancing MYH9 ubiquitination mediated by STUB1 and USP14.
Yan D, Tong W, You W, Zhou W, Huang S, Liu H, Huang X, Luo Q, Ye J
Biochimica et biophysica acta. Molecular basis of disease 2026 Apr 7;1872(6):168239
Biochimica et biophysica acta. Molecular basis of disease 2026 Apr 7;1872(6):168239
USP10 from Human Umbilical Cord Mesenchymal Stem Cells-Derived Extracellular Vesicles Mediates SCL7A11 Deubiquitination in Epithelial Cells: A Key to Anti-ferroptosis and Anti-fibrosis in Pulmonary Fibrosis.
Zhuo Y, Lin L, Lin N, Lai F
Lung 2026 Apr 29;204(1)
Lung 2026 Apr 29;204(1)
Targeting WWP1 ameliorates osteoarthritis by suppressing KLF15 ubiquitination to restore mtDNA and mitochondrial function.
Li Z, Lan W, Luo Y, Liu P, Li X, Li H
Molecular genetics and genomics : MGG 2026 Apr 24;301(1)
Molecular genetics and genomics : MGG 2026 Apr 24;301(1)
18-β-glycyrrhetinic acid facilitates nuclear-mitochondrial communications to alleviate oxidative stress through HMGB1-cGAS-Mul1 axis in tendinopathy.
Gao YY, Sun WS, Sun ZY, Wang JR, Lv ZY, Li YJ, Tian HY, Bao ZY, Qiu XR, Wang Z, Zheng SZ, Shao JJ, Zhang ZL, Meng J
Journal of translational medicine 2026 Apr 17;24(1)
Journal of translational medicine 2026 Apr 17;24(1)
Pellino1 Exacerbates Diabetic Kidney Disease Through NLRP3 Inflammasome Driven Pyroptosis in Renal Tubular Epithelial Cells.
Zhou X, Zhang R, Guo Z, Yang Y, Yan R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 15;40(7):e71721
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 15;40(7):e71721
Pathogenic mechanisms of amyotrophic lateral sclerosis-linked VAPB P56S mutation in the degeneration of corticospinal motor neurons.
Yang X, Zheng J, Wang X, Cai H, Yu J
Ageing and neurodegenerative diseases 2025;5(3)
Ageing and neurodegenerative diseases 2025;5(3)
TRIM32 promotes neuronal ferroptosis by enhancing K63-linked ubiquitination and subsequent p62-selective autophagic degradation of GPX4.
Zhou X, Zhao Y, Huang S, Shu H, Zhang Y, Yang H, Ren Y, Zhou X, Liu W, Song T, Zhao J, Ma J
International journal of biological sciences 2025;21(3):1259-1274
International journal of biological sciences 2025;21(3):1259-1274
Heat acclimation mediates cellular protection via HSP70 stabilization of HIF-1α protein in extreme environments.
Li C, Wen J, Wang L, Lei J, Lin Z, Zou Y, Cheng J, Wan X, Liu J, Wu J
International journal of biological sciences 2025;21(1):175-188
International journal of biological sciences 2025;21(1):175-188
Integrated Analysis of Single-Cell RNA Sequencing and Machine Learning Reveals a T Cell-Specific PANoptosis Signature Predicting Prognosis and Immunotherapy in Prostate Cancer.
Wang H, Li W, Deng W, Wu J, Li K, Huang X
Human mutation 2025;2025:8889021
Human mutation 2025;2025:8889021
cnnm-5 knockdown improves proteostasis of mutant Huntingtin protein in C. elegans.
Hull M, Mills J
microPublication biology 2025;2025
microPublication biology 2025;2025
Inhibition of HPSE/SDC-2 axis-induced epithelial-mesenchymal transition for treating IC/BPS.
Chen Z, He Y, Zhang J, Ge Q, Du T, Fan Z, Zhou J, Yang X, Shen B, Wei Z
PloS one 2025;20(5):e0321730
PloS one 2025;20(5):e0321730
TRIM37-mediated stabilization of PEX5 via monoubiquitination attenuates oxidative stress and demyelination in multiple sclerosis insights from EAE and LPC-induced experimental models.
Jiang L, Jin Y, Han Y, Fu J
PloS one 2025;20(10):e0335198
PloS one 2025;20(10):e0335198
Over-expressed Phospholamban in Cancer-associated Fibroblasts Is a Driver for CMS4 Subtype Colorectal Cancer Formation.
Li T, Fei Y, Sun X, Zhu J, Fang X, Meng F, Wang D, Zhang X, Liu C, Du Q
Cellular and molecular gastroenterology and hepatology 2025;19(9):101524
Cellular and molecular gastroenterology and hepatology 2025;19(9):101524
Elevated Bile Acids Induce Circadian Rhythm Sleep Disorders in Chronic Liver Diseases.
Zhou L, Yan M, Luo Q, Qiu W, Guo YR, Guo XQ, Yu HB, Huo JR, Feng YL, Wang DP, Sun T, Wang KF, Shi JY, Shang X, Wu MN, Wang L, Cao JM
Cellular and molecular gastroenterology and hepatology 2025;19(3):101439
Cellular and molecular gastroenterology and hepatology 2025;19(3):101439
Parishin A ameliorates cognitive decline by promoting PS1 autophagy in Alzheimer's disease.
Guo S, Yi L, Luo M, Dong Z, Du Y
Frontiers in aging neuroscience 2025;17:1516190
Frontiers in aging neuroscience 2025;17:1516190
Farrerol inhibits ferroptosis and protects against LPS-induced acute lung injury by targeting the RUNX1/SLC7A11 axis.
Yang Y, Deng S, Liu T, Yin Q, Yang M, Zhang X, Jiang Z, Wang X, Zhang S, Zhang T, Wu D, Xu Y
Frontiers in immunology 2025;16:1720843
Frontiers in immunology 2025;16:1720843
PSMD12 promotes hepatocellular carcinoma progression by stabilizing CDK1.
Peng X, Liu Z, Luo C, Sun R, Zhang Y, Li B, Zou Y, Zhu J, Yuan R
Frontiers in immunology 2025;16:1581398
Frontiers in immunology 2025;16:1581398
TFEB promotes Ginkgetin-induced ferroptosis via TRIM25 mediated GPX4 lysosomal degradation in EGFR wide-type lung adenocarcinoma.
Wang HJ, Dong LF, Ding LL, Miao XY, Zhang YW, Zhao LP, Yu LH, Guan ZR, Jiang YP, Tang XQ, Yan YX, Lou JS
Theranostics 2025;15(7):2991-3012
Theranostics 2025;15(7):2991-3012
PINX1 inhibits proliferation and cisplatin resistance in nasopharyngeal carcinoma by promoting ILF3 ubiquitination.
Zhou N, Gong P, Wang S, He C, Hu L, Peng H
American journal of cancer research 2025;15(6):2518-2534
American journal of cancer research 2025;15(6):2518-2534
The status of p53 affects the efficacy of PLK1 inhibitor BI6727 in prostate cancer cells.
Li W, Wang Y, Guo W, Wen D
Frontiers in cell and developmental biology 2025;13:1602693
Frontiers in cell and developmental biology 2025;13:1602693
Tetrahydrocurcumin targets TRIP13 inhibiting the interaction of TRIP13/USP7/c-FLIP to mediate c-FLIP ubiquitination in triple-negative breast cancer.
Sun YJ, Zhang Q, Cao SJ, Sun XH, Zhang JC, Zhang BY, Shang ZB, Zhao CY, Cao ZY, Zhang QJ, Gao XM, Qiu F, Kang N
Journal of advanced research 2025 Sep;75:591-605
Journal of advanced research 2025 Sep;75:591-605
Phytosphingosine Alleviates Cigarette Smoke-Induced Bronchial Epithelial Cell Senescence in Chronic Obstructive Pulmonary Disease by Targeting the Free Fatty Acid Receptor 4.
Zhan Y, Deng Z, Yang R, Chen S, Zhang J, Zhang Y, Fu H, Huang Q, Gu Y, Zeng Z, Chen J, Zhang J, Wu J, Xie J
MedComm 2025 Sep;6(9):e70345
MedComm 2025 Sep;6(9):e70345
HDAC1/2-mediated deacetylation of KLF9 promotes the malignant progression of nasopharyngeal carcinoma via CDH17.
Zhang K, Peng X, Zhou P, Li X, Shen L, Yang L, Zhou Q
Oncogene 2025 Sep;44(35):3183-3198
Oncogene 2025 Sep;44(35):3183-3198
Interplay mechanism of virus latency-reactivation by human cytomegalovirus UL82 protein with the host core histone H3K27 methyltransferase EZH2 of polycomb repressive complex 2.
Huo X, Xia S, Cheng B, Xiong W, Li Q, Yang X, Ran Y, Li H, Chen J
International journal of biological macromolecules 2025 Sep;322(Pt 3):146753
International journal of biological macromolecules 2025 Sep;322(Pt 3):146753
Inhibition of USP5 Attenuates Atherosclerosis by Suppressing PDCD4-Mediated Endothelial Dysfunction: Evidence from In Vitro HUVEC and In Vivo Models.
Chen Y, Wang Y, Wu T, Guo X, Bai X, Wang L, Yan P, Zheng Z, Xiao L, Li L
Cardiovascular toxicology 2025 Sep;25(9):1272-1287
Cardiovascular toxicology 2025 Sep;25(9):1272-1287
Triflupromazine and tranylcypromine alleviate primary cisplatin resistance in lung adenocarcinoma by promoting LDHA-mediated AMBRA1 ubiquitination.
Wang Q, Zhang Y, Zhang Y, Zhai Y, Zhou X, Qin Y, Ding M, Tian Y, Zhang Z, Zhang P, Xu F
Biochemical pharmacology 2025 Sep;239:117073
Biochemical pharmacology 2025 Sep;239:117073
USP48 protects against myocardial ischemia-reperfusion injury by stabilizing and upregulating CNN1 in type 1 diabetes mice.
Su JB, Chen G, Sun QY, Fu X, Wu LX, Qiu HB, Lv ZL, Hu JY, Wang Y, Zhuang YY, Sun HJ, Lu QB, Zhang JR, Zhu XX
Metabolism: clinical and experimental 2025 Sep;170:156326
Metabolism: clinical and experimental 2025 Sep;170:156326
ANAPC5 mitigates acute lung injury through regulating macrophage M1/M2 polarization via the EGFR/CD24 axis.
Wang Y, Zhang X, Zhang J, Zhao M, Chong Y, Gu Q, Meng X, Zhao M
Cellular immunology 2025 Sep-Oct;415-416:105013
Cellular immunology 2025 Sep-Oct;415-416:105013
Targeting the IRS1 macromolecular signaling node by Trienomycin a triggers cytoprotective autophagy in pancreatic adenocarcinoma.
Li MJ, Zhang R, Sheikho A, Tang JJ, Gao YQ, Huang WW, Gao JM
International journal of biological macromolecules 2025 Sep 8;328(Pt 2):147547
International journal of biological macromolecules 2025 Sep 8;328(Pt 2):147547
Fine particulate matter exacerbates asthma by activating STC2-mediated mitophagy through METTL3/YTHDF2-dependent m6A methylation.
Liu Y, Li G, Xiong A, Liu J, Zeng R, Zhang L, Wang J, Jiang M, Gao J, Xiong Y, He X
Journal of hazardous materials 2025 Sep 5;495:138854
Journal of hazardous materials 2025 Sep 5;495:138854
The E3 ubiquitin ligase SCFLAO1 promotes NITRITE REDUCTASE degradation to modulate growth and oilseed production in Brassica napus.
Li Y, Cheng S, Xu Y, Sun N, Dong J
Plant physiology 2025 Sep 30;199(2)
Plant physiology 2025 Sep 30;199(2)
CHD4 drives gastric cancer metastasis via MYH9/GSK3β/β-catenin axis and WNT/EMT pathway activation.
Shi Y, Zhao Z, Zhou S, Zhou Z, Huang Z, Zhou Z, Zhang C
Cancer letters 2025 Sep 28;628:217813
Cancer letters 2025 Sep 28;628:217813
USP5 inhibition enables potential therapy for t(8;21) AML through ubiquitin-mediated AML1-ETO degradation in patient-derived xenografts.
Ma L, Zhang K, Zhang Z, Wang C, Ma M, Liu Y, Zhao Y, Gong Z, Liu N, Wei M, Liu X, Zhou J, Liu S, Yang C, Yang G
Science translational medicine 2025 Sep 24;17(817):eadt9100
Science translational medicine 2025 Sep 24;17(817):eadt9100
Cancer-associated fibroblast derived CXCL14 drives cisplatin chemoresistance by enhancing nucleotide excision repair in bladder cancer.
Li T, Zhu K, Tong H, Sun Y, Zhu J, Qin Z, Chen J, Wu L, Zhang X, Wang A, Gou X, Yin H, He W
Journal of experimental & clinical cancer research : CR 2025 Sep 2;44(1):265
Journal of experimental & clinical cancer research : CR 2025 Sep 2;44(1):265
METTL3-mediated m6A modification of FUNDC1/IP3R2 pathway facilitates cardiac hypertrophy in obesity hypertension.
Ma Y, Li D, Zhou X, Chen X, Hou C, Li Y, Zhao Y, Gui M, Yao L, Li J, Wang M, Fu D, Lu B
Life sciences 2025 Sep 15;377:123780
Life sciences 2025 Sep 15;377:123780
ASS1 inhibits liver cancer by promoting CAD ubiquitination and reversing the urea cycle and pyrimidine synthesis imbalance.
Ming Z, Luo T, Zou Z, Luo W, Hu X, Chen L, Zhou J, Liu X, Liu M, Li J, Luo J, Ma D, Liu S, Luo Z
Hepatology communications 2025 Sep 1;9(9)
Hepatology communications 2025 Sep 1;9(9)
Environmental aminomethylphosphonic acid (AMPA) exposure increased the risk of spontaneous abortion through lactate-induced JunB lactylation in trophoblast.
Kong C, Li R, Wang X, Li L, Kang N, Zhen X, Dong Y, Yan G
Ecotoxicology and environmental safety 2025 Sep 1;302:118743
Ecotoxicology and environmental safety 2025 Sep 1;302:118743
YY1-induced USP43 drives ferroptosis suppression by FASN stabilization and subsequent activation of SLC7A11 in ovarian cancer.
Zhao T, Chen X, Wu J, Chen S, Gan Y, Liu C, Ha X, Wu Y, Zhou X, Wu Y, Wu X
Cell death & disease 2025 Sep 1;16(1):589
Cell death & disease 2025 Sep 1;16(1):589
Parkin modulates the hepatocellular carcinoma microenvironment by regulating PD-1/PD-L1 signalling.
Ye G, Sun X, Li J, Pu M, Zhang J
Journal of advanced research 2025 Oct;76:731-744
Journal of advanced research 2025 Oct;76:731-744
USP47 Regulates Excitatory Synaptic Plasticity and Modulates Seizures in Murine Models by Blocking Ubiquitinated AMPAR Degradation.
Yang J, Zhang H, Wang Y, Luo Y, Zheng W, Liu Y, Jiang Q, Deng J, Liu Q, Zhang P, Huang H, Yu C, Xu Z, Chen Y
Neuroscience bulletin 2025 Oct;41(10):1805-1823
Neuroscience bulletin 2025 Oct;41(10):1805-1823
SUMOylation of ZEB1 Modulates PANoptosis in Burn-Induced Early Acute Kidney Injury.
Zhang J, Huang Z, Lin Q, Zhong H, Hu W, Zhang F, Huang J
Journal of cellular and molecular medicine 2025 Oct;29(20):e70865
Journal of cellular and molecular medicine 2025 Oct;29(20):e70865
FATS alleviates ulcerative colitis by inhibiting M1 macrophage polarization and aerobic glycolysis through promoting the ubiquitination-mediated degradation of HIF-1α.
Han Y, Xun J, Li T, Jiang X, Liu B, Hu Z, Yang H, Gao Q, Wu Z, Wu X, Zhang A, Wang X, Guan Z, Yu X, Zhang Q
Biochemical pharmacology 2025 Oct;240:117053
Biochemical pharmacology 2025 Oct;240:117053
Mouse mesenchymal stem cell-derived exosomal miR-205-5p modulates LPS-induced macrophage polarization and alleviates lung injury by regulating the USP7/FOXM1 axis.
Feng Y, Tang M, Li H, Yao S, Li B
Drug delivery and translational research 2025 Oct;15(10):3480-3496
Drug delivery and translational research 2025 Oct;15(10):3480-3496
Tumor suppressor FBXO11 drives ubiquitin proteasomal degradation of KIF2C to limit ovarian cancer progression and is transcriptionally repressed by ZNF217.
Chen Q, Ouyang L
Cellular signalling 2025 Oct;134:111910
Cellular signalling 2025 Oct;134:111910
Fusidic Acid Reverses Chemoresistance in Breast Cancer via Targeting DDX6 to Downregulate GSK-3β/β-Catenin Signaling.
Fan X, Guo D, Li S, Tian J, Zhang C, Li Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e04680
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e04680
Clathrin light chain 2 is a substrate of ubiquitin ligase ATL5 and negatively regulates seed longevity in Arabidopsis.
Lyu Y, He W, Zhou X, Gao X, Fan M, Chen D, Chen X
Journal of experimental botany 2025 Oct 9;76(16):4684-4695
Journal of experimental botany 2025 Oct 9;76(16):4684-4695
Degradation of NLRP3 by selective ROCK2 inhibitor alleviates acute lung injury.
Zhan S, Zhang N, Lou Y, Ding X, Chen Z, Huang Y, Ding W
European journal of pharmacology 2025 Oct 5;1004:178009
European journal of pharmacology 2025 Oct 5;1004:178009
Pupylation-based proximity labeling reveals APC/C-mediated ubiquitination and degradation of PEROXIN11C in soybean abiotic stress responses.
Zhang Y, Yang X, Chen T, Su K, Zhu Y, Li S, Xiang F, Lu Q
Cell reports 2025 Oct 28;44(10):116331
Cell reports 2025 Oct 28;44(10):116331
Ubiquitin-specific protease 7 regulates macrophage polarization via pyruvate kinase M2-mediated metabolic reprogramming in severe acute pancreatitis.
Wu Y, Yao X, Yu Q, Yan Q, Huang X, Ke H, Peng C, Xia L
Cell death & disease 2025 Oct 27;16(1):764
Cell death & disease 2025 Oct 27;16(1):764
The deubiquitination enzyme USP14 promotes the tumourigenesis of gastric cancer by enhancing c-MYC nuclear translocation through deubiquitination of KPNA2.
Li J, Tang H, Chang H, Du Y, Du L, Zhao E
Cell death & disease 2025 Oct 21;16(1):737
Cell death & disease 2025 Oct 21;16(1):737
E3 ubiquitin ligase BTRC inhibits the proliferation and tumor growth of glioma cells through the NFAT5/AQP4 axis.
Li Y, Tang S, Jiang K, Deng P, Hu X
Journal of cancer research and clinical oncology 2025 Oct 21;151(12):301
Journal of cancer research and clinical oncology 2025 Oct 21;151(12):301
Nephroprotective mechanism of Kunkui Baoshen decoction in diabetic kidney disease: Targeting the HERC2/NCOA4-mediated autophagy-dependent ferroptosis pathway.
Song SY, Shan CC, Zhou PP, Xu WL, Tan Y, Zhou XQ, Huang LJ, Yan QH, Yu JY
World journal of diabetes 2025 Oct 15;16(10):109568
World journal of diabetes 2025 Oct 15;16(10):109568
PDLIM4 drives gastric cancer malignant progression and cisplatin resistance by inhibiting HSP70 ubiquitination and degradation via competitive interaction with STUB1.
Zhu C, Chen M, Fan L, Wang Y, Liu M, Kang G, Yin F, Tang H, He Y, Zhang S, Zeng L, Liu W, Yu K, Le A
Journal of nanobiotechnology 2025 Oct 11;23(1):661
Journal of nanobiotechnology 2025 Oct 11;23(1):661
Albiflorin attenuates post-myocardial infarction cardiac fibrosis through inhibiting the RAS-ERK/MAPK signaling pathway.
Lv M, Yu Y, Niu H, Yu D
Biochemical and biophysical research communications 2025 Oct 1;783:152644
Biochemical and biophysical research communications 2025 Oct 1;783:152644
TRIM39-mediated deubiquitination upregulates RNF168 to evade autophagy-ferroptosis in triple-negative breast cancer.
Yao X, Shen X, Fan Y, Wang H
NPJ breast cancer 2025 Oct 1;11(1):108
NPJ breast cancer 2025 Oct 1;11(1):108
Development of an efficient mice model of cancer-associated cardiac cachexia.
Xiong S, Zheng H, Wu T, Tan J, Huang T, Shen C, Ji Y, Liu M, Wan J, Cai W
Animal models and experimental medicine 2025 Nov;8(11):1960-1970
Animal models and experimental medicine 2025 Nov;8(11):1960-1970
Aging-associated ZNF573 methylation regulates RNF19B-PIK3CA ubiquitination to promote prostate cancer.
Ge Y, Han P, Sun Y, Chen Y, Shi Q, Cui L, Yuan Q, Ma G
Oncogene 2025 Nov;44(44):4298-4308
Oncogene 2025 Nov;44(44):4298-4308
NMRK2 leads to the depletion of CD8(+)T cells by mediating the enhancement of NAD(+)-SIRT1-CD38 axis in PRCC-TFE3 rRCC.
Chen Y, Liu X, Wu M, Dong X, Ma W, Feng F, Ding Y, Dong P, Ding W, Zhang L, Liu N, Gan W, Li D
Oncogene 2025 Nov;44(44):4223-4238
Oncogene 2025 Nov;44(44):4223-4238
13-Docosenamide Enhances Oligodendrocyte Precursor Cell Differentiation via USP33-Mediated Deubiquitination of CNR1 in Chronic Cerebral Hypoperfusion.
Xu Y, Tan Y, Zhang Z, Chen D, Zhou C, Sun L, Xia S, Bao X, Yang H, Xu Y
Neuroscience bulletin 2025 Nov;41(11):1939-1956
Neuroscience bulletin 2025 Nov;41(11):1939-1956
MiR-126-5p Derived From Bone Marrow Mesenchymal Stem Cell Exosomes Promotes Skeletal Muscle Regeneration by Regulating FBXO32/MyoD Signaling.
Yan Y, Zheng M, Wang X, Fu T, Qi J, Wei X, Sun Y, Lu J, Luo X, Wang Y, Wang H
Acta physiologica (Oxford, England) 2025 Nov;241(11):e70114
Acta physiologica (Oxford, England) 2025 Nov;241(11):e70114
Sinapic acid and glabridin synergistically mitigate androgenetic alopecia by modulating ferroptosis through stabilization of β-catenin against ubiquitin-dependent degradation.
Huang Z, Weng Z, Yuan J, Liu Y, Fu H, Xie Y, Li Y, Feng S, Mao Q, Luo K, Ding B
Biochemical pharmacology 2025 Nov;241:117171
Biochemical pharmacology 2025 Nov;241:117171
Silymarin ameliorates diet-induced gallstone formation by regulating gut microbiota-derived GCDCA to suppress ferroptosis-ROS-NFκB signaling pathway.
Wang Q, Han C, Zheng Y, Liu X, Lv Z, Du Z, Liu T, Hao C, Meng X, Li T, Xue D
Free radical biology & medicine 2025 Nov;239:496-512
Free radical biology & medicine 2025 Nov;239:496-512
Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.
Liu R, Chen Y, Huang H, Li X, Lv J, Jiang L, Jiang H, Wu C, Chen W, Xu H, Zhu Z, Cai H, Xiao J, Yin L, Ni W
British journal of pharmacology 2025 Nov;182(22):5489-5516
British journal of pharmacology 2025 Nov;182(22):5489-5516
CERKL Reduced PI3P/Autophagy to Promote Pancreatic Cancer.
Zeng W, Yang Y, Li W, Pan J, Huang B, Zhang P, Xiao J
Cancer medicine 2025 Nov;14(22):e71402
Cancer medicine 2025 Nov;14(22):e71402
O-GlcNAcylation of PRDX1 enhances its stability and promotes liver cancer progression via activating LRP6-mediated Wnt signaling.
Dai L, Xu Z, Fan Y, Gao W, Yuan G, He S, Mao L
Cellular signalling 2025 Nov;135:112055
Cellular signalling 2025 Nov;135:112055
Role of EZH2 in regulating c-Myc stability through the E3 ubiquitin ligase HUWE1 in heart failure and its mechanisms.
Yan L, Xie D, Huang T, Zheng H, Huang J, Chen H, Xie Q, Weng G, Zheng F
Cellular signalling 2025 Nov;135:111968
Cellular signalling 2025 Nov;135:111968
APOL2 Stabilizes Ku80 to Confer NHEJ-Mediated Radioresistance in Gastric Cancer.
Zu D, Bao Q, He H, Zhong Y, Deng M, Hu Y, Zhang C, Liang C, Huang Y, Liu H, Li X, He Y, Luo G, Wu W, Guan F, Xu S, Liu M, Bacolla A, Jing J, Du Y, Tainer JA, Shi Y, Ye Z, Cheng X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e06294
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e06294
NCOA4-dependent ferritinophagy drives perfluorooctanoic acid-triggered renal ferroptosis in chicken embryos.
Yang J, Wen X, Fu YT, Li C, Chang HL, Lu YY, Li XR, Fan RF
Journal of hazardous materials 2025 Nov 5;499:140112
Journal of hazardous materials 2025 Nov 5;499:140112
SUN5 interacts with TRIM28, enhancing IκBα ubiquitination to promote glycolysis in colorectal cancer cells.
Chen J, Yang Y, Liu G, Huang L, Zhang Y, Wang Y, Xu X, Xing X
Acta biochimica et biophysica Sinica 2025 Nov 27;57(12):2094-109
Acta biochimica et biophysica Sinica 2025 Nov 27;57(12):2094-109
Oxidative stress reactivates androgen receptor signaling via USP36 to drive castration resistance in prostate cancer.
Fan C, Huang Z, Gao J, Gu Y, Wang N, Zhou B
Scientific reports 2025 Nov 26;15(1):42185
Scientific reports 2025 Nov 26;15(1):42185
Activation of the aryl hydrocarbon receptor relieves acute pancreatitis via the RBX1/HSF1 pathway.
Fang Y, Zhang C, Yu J, Shen X
Journal of inflammation (London, England) 2025 Nov 22;22(1):54
Journal of inflammation (London, England) 2025 Nov 22;22(1):54
CDC26 facilitates ferroptosis through SLC7A11 degradation and cell cycle arrest.
Lin J, Chen F, Tang H, Cai X, Huang M, Liang R, Kang R, Tang D, Liu J
Clinical and experimental medicine 2025 Nov 18;26(1):11
Clinical and experimental medicine 2025 Nov 18;26(1):11
BRD4 inhibition suppresses histone H4 UFMylation to increase ferroptosis sensitivity through TXNIP.
Yang Z, Wang B, Guo B, Sun S, Li Y, Lu J, Cao X, Wang H, Wang X, Guo Y, Wu T
Cell death & disease 2025 Nov 17;16(1):843
Cell death & disease 2025 Nov 17;16(1):843
CNOT7 facilitates radiation resistance in colorectal cancer through TRIM21/XRCC6-mediated non-homologous end joining repair.
Li Y, Cui L, Wang S, Zhao Q, Du F, Du S, Yu C, Xia M, Zhao S, Luan T, Liu Y, Cui B
Cell death & disease 2025 Nov 17;16(1):833
Cell death & disease 2025 Nov 17;16(1):833
INHBA promotes chemoresistance in pancreatic cancer by enhancing CTPS1 stability and mediating pyrimidine metabolism.
Sun X, Wei Z, Liao X, Zheng D, Li F, Chen L, Gong Y, Ran S, Han X, He Z, Yu C
Cancer cell international 2025 Nov 14;25(1):403
Cancer cell international 2025 Nov 14;25(1):403
PNMA4 enhances anti-RNA virus immunity by promoting RIG-I signaling pathway.
Song H, Li ZW, Xie YT, Tang X, Hu YT, Tan Y, Huang Y, Cheng YL, Pei G, Kuang M
International immunopharmacology 2025 Nov 14;165:115446
International immunopharmacology 2025 Nov 14;165:115446
RNF180 suppressed aggressiveness by degrading NOTCH1, TRIM24 and FOXC1, and chemoresistance by degrading ACC1 and ACLY in colorectal cancer.
Li N, Zhang R, Zhao XX, Zhou L, Li YL, Cui ZG, Zheng HC
International immunopharmacology 2025 Nov 14;165:115445
International immunopharmacology 2025 Nov 14;165:115445
Poricoic Acid A attenuated TGF-β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells through SPRY2/ERK signaling pathway.
Xiang M, Chen H, Lin X
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2025 Nov 1;29(6):727-739
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2025 Nov 1;29(6):727-739
ELK1 inhibition alleviates amyloid pathology and memory decline by promoting the SYVN1-mediated ubiquitination and degradation of PS1 in Alzheimer's disease.
Yi L, Li J, He Y, Wang J, Wang M, Guo S, Luo M, Wu B, Xu M, Tian Q, Fan Y, Chen M, Xu B, Xia L, Song W, He G, Du Y, Dong Z
Experimental & molecular medicine 2025 May;57(5):1032-1046
Experimental & molecular medicine 2025 May;57(5):1032-1046
Bacteria escape macrophage-mediated phagocytosis via targeting apurinic/apyrimidinic endonuclease 1 in sepsis.
Zhou Y, Yan X, Wu Y, Qi Y, Yu T, Pan F, He L, Guo Z, Hu Z
International journal of biological macromolecules 2025 May;305(Pt 2):141278
International journal of biological macromolecules 2025 May;305(Pt 2):141278
Dihydroartemisinin requires NR1D1 mediated Rab7 ubiquitination to regulate hepatic stellate cells lipophagy in liver fibrosis.
Bao Z, Xu M, Kan Y, Guo X, Li M, Wang J, Zhou Y, Zhang Z, Shao J, Zhang F, Chen L, Zheng S, Xuan J
International journal of biological macromolecules 2025 May;305(Pt 1):141055
International journal of biological macromolecules 2025 May;305(Pt 1):141055
KIF9 Ameliorates Neuropathology and Cognitive Dysfunction by Promoting Macroautophagy in a Mouse Model of Alzheimer's Disease.
Wang M, Guo S, Yi L, Li Z, Shi X, Fan Y, Luo M, He Y, Song W, Du Y, Dong Z
Aging cell 2025 May;24(5):e14490
Aging cell 2025 May;24(5):e14490
EPIC-1042 alleviates cerebral ischemic/reperfusion injury through TAX1BP1-induced mitophagy.
Ju J, Cheng C, Cui L, Hong B, Zhan Q, Wang Q, Cui X, Su D, Huang Y, Kang C
Free radical biology & medicine 2025 May;232:367-381
Free radical biology & medicine 2025 May;232:367-381
METTL7B-induced histone lactylation prevents heart failure by ameliorating cardiac remodelling.
Chen Z, Zhong M, Lin Y, Zhang W, Zhu Y, Chen L, Huang Z, Luo K, Lu Z, Huang Z, Yan Y
Journal of molecular and cellular cardiology 2025 May;202:64-80
Journal of molecular and cellular cardiology 2025 May;202:64-80
The Novel Dual GIP and GLP-1 Receptor Agonist Tirzepatide Attenuates Colon Cancer Development by Regulating Glucose Metabolism.
Zhang Y, Xie Y, Xia S, Ge X, Li J, Liu F, Jia F, Wang S, Zhou Q, Gao M, Fang W, Zheng C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2411980
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2411980
DAPK3 is Essential for DBP-Induced Autophagy of Mouse Leydig Cells.
Yang S, Yang Y, Xu L, Hao C, Chen J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2413936
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2413936
SIZ1 SUMOylates and stabilizes WRI1 to safeguard seed filling and fatty acid biosynthesis under high-temperature stress.
Huang R, Wen M, Feng B, Wu P, Zhong X, Yang Y, Liu M, Li H, Yang C, Peng C, Zhang S
The Plant cell 2025 May 9;37(5)
The Plant cell 2025 May 9;37(5)
HucMSCs-Derived Extracellular Vesicles Deliver RPS27A Protein to Manipulate the MDM2-P53 Axis and Ameliorate Neurological Dysfunction in Parkinson's Disease.
Xu J, Lei H, Yang C, Qiu Y, Wu X
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 May 8;20(1):52
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 May 8;20(1):52
Forsythoside A Alleviates Acute Alcoholic Liver Injury by Binding to TLR4 to Inhibit the Activation of the NF-κB Pathway.
Wang Y, Ma Y, Tuo P, Naeem A, Tang Y, Su Q, Li H, Gao X, Wang X
Phytotherapy research : PTR 2025 May 8;
Phytotherapy research : PTR 2025 May 8;
Tspan9 Exacerbates Cardiac Hypertrophy by Impairing Cardiac Autophagy.
Jiang S, Bu S, Kang X, Dong Y, Chen L, Yuan L, Shi M, Du M, Liang M, Huang K, Yang L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 31;39(10):e70670
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 31;39(10):e70670
LM2I leads to CAD ubiquitination and liver cancer suppression through activation of ASS1.
Ming Z, Luo T, Zou Z, Luo W, Hu X, Chen L, Zhou J, Liu X, Liu M, Li J, Ma D, Liu S, Luo Z
Acta biochimica et biophysica Sinica 2025 May 30;58(3):551-561
Acta biochimica et biophysica Sinica 2025 May 30;58(3):551-561
PICK1 overexpression ameliorates endotoxin-induced acute lung injury by regulating mitochondrial quality control via maintaining Nrf-2 stabilization through activating the PI3K/Akt/GSK-3β pathway and disrupting the E3 ubiquitin ligase adapter β-TrCP.
Qian M, Zhu Y, Lin W, Lian H, Xia Y, Papadimos T, Wang J
International immunopharmacology 2025 May 27;156:114685
International immunopharmacology 2025 May 27;156:114685
NAP1L1 degradation by FBXW7 reduces the deubiquitination of HDGF-p62 signaling to stimulate autophagy and induce primary cisplatin chemosensitivity in nasopharyngeal carcinoma.
Gong B, Liu Y, Yan W, Cheng C, Yang H, Huang J, Liu Q, Liu Y, Guo J, Deng X, Zhou B, Zheng D, Liu X, Liu Z, Fang W
Molecular cancer 2025 May 26;24(1):152
Molecular cancer 2025 May 26;24(1):152
The novel tRNA-derived fragment, tiRNA-Met, inhibits the malignant progression of triple-negative breast cancer by regulating RANBP3L via a targeted interaction with SNRPA.
Lu J, Sun Y, Zhang X, Xu B, Zhu P, Zeng L, Wang X, Zhu W, Zhou P
Cellular & molecular biology letters 2025 May 23;30(1):62
Cellular & molecular biology letters 2025 May 23;30(1):62
USP14 inhibits mitophagy and promotes tumorigenesis and chemosensitivity through deubiquitinating BAG4 in microsatellite instability-high colorectal cancer.
Wang Z, Yu C, Xie G, Tao K, Yin Z, Lv Q
Molecular medicine (Cambridge, Mass.) 2025 May 2;31(1):163
Molecular medicine (Cambridge, Mass.) 2025 May 2;31(1):163
ANXA1 promotes intrahepatic cholangiocarcinoma proliferation and growth by regulating glutamine metabolism through GOT1 stabilization.
Gong Y, Chen L, Wang H, Zheng D, Li F, Wu C, Li Y, Deng Y, He Z, Yu C
Journal of experimental & clinical cancer research : CR 2025 May 19;44(1):151
Journal of experimental & clinical cancer research : CR 2025 May 19;44(1):151
Perfluorooctane sulfonate induced ferritinophagy via detyrosinated alpha tubulin-TRIM21-HERC2-regulated NCOA4 degradation in hepatocytes.
Feng R, Hu L, Yang W, Liang P, Li Y, Tian K, Wang K, Qiu T, Zhang J, Sun X, Yao X
Environmental pollution (Barking, Essex : 1987) 2025 May 15;373:126101
Environmental pollution (Barking, Essex : 1987) 2025 May 15;373:126101
Engineered Spirulina platensis for treating rheumatoid arthritis and restoring bone homeostasis.
Yang X, Rong K, Fu S, Yang Y, Liu S, Zhang C, Xu K, Zhang K, Zhu Y, Hao Y, Zhao J, Fu J
Nature communications 2025 May 13;16(1):4434
Nature communications 2025 May 13;16(1):4434
CPT1A/HIF-1α positive feedback loop induced fatty acid oxidation metabolic pathway contributes to the L-ascorbic acid-driven angiogenesis in breast cancer.
Ma X, Zhang B, Yin X, Yang S, Lin Z, Yang Y, Zhou X
Breast cancer research : BCR 2025 May 12;27(1):74
Breast cancer research : BCR 2025 May 12;27(1):74
HBV core protein enhances WDR46 stabilization to upregulate NUSAP1 and promote HCC progression.
Kong F, Bao E, Zhong Y, Wang Y, Liu R, Zhang H, Yang L, Jiang R, Liu X, Li C, Liu X, Pan X, Zheng K, You H, Tang R
Hepatology communications 2025 May 1;9(5)
Hepatology communications 2025 May 1;9(5)
Noncanonical feedback loop between "RIP3-MLKL" and "4EBP1-eIF4E" promotes neuronal necroptosis.
Wang S, Zhang Y, Wang M, Zhai Z, Tan Y, Xu W, Ren X, Hu X, Mo J, Liu J, Yang Y, Chen D, Jiang B, Huang H, Huang J, Xiong K
MedComm 2025 Mar;6(3):e70107
MedComm 2025 Mar;6(3):e70107
Down-regulation of Selenoprotein K impairs the proliferation and differentiation of chicken skeletal muscle satellite cells by inhibiting the Nrf2 antioxidant signaling pathway.
Chen XW, Li Y, Fu YT, Xu WX, Yang J, Wen X, Fan RF
Free radical research 2025 Mar;59(3):215-225
Free radical research 2025 Mar;59(3):215-225
The MCM6-c-Myc positive feedback loop mediates bladder cancer progression and cisplatin resistance.
Wang J, Li X, Zhao L, Fan X, Cao J, Wang S, Li K, Wang H, Zhang Y, Wang H, Xu C, Ding L, Che T, Chen S, Yang L
International journal of biological macromolecules 2025 Mar;296:139777
International journal of biological macromolecules 2025 Mar;296:139777
Extracellular Ubiquitin Enhances Autophagy and Inhibits Mitochondrial Apoptosis Pathway to Protect Neurons Against Spinal Cord Ischemic Injury via CXCR4.
Feng H, Chen D, Chen H, Wu D, Wang D, Yu Z, Zhou L, Wang Z, Liu W
Neurospine 2025 Mar;22(1):157-172
Neurospine 2025 Mar;22(1):157-172
Mitochondrial ROS-associated integrated stress response is involved in arsenic-induced blood-testis barrier disruption and protective effect of melatonin.
Niu FW, Liu MD, Yao K, Yang R, Gao L, Zhai JX, Wang C, Zhang SH, Xu DX, Zhang ZH
Environment international 2025 Mar;197:109346
Environment international 2025 Mar;197:109346
Renal tubular S100A7a impairs fatty acid oxidation and exacerbates renal fibrosis via both intracellular and extracellular pathway.
Sun P, Chen Q, Chen X, Zhou J, Long T, Ma Y, Zhou M, Hu Z, Tian J, Zhu F, Yang Z, Xie L, Wu Q, Nie J
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167656
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167656
Targeting YBX1-m5C mediates RNF115 mRNA circularisation and translation to enhance vulnerability of ferroptosis in hepatocellular carcinoma.
Li O, An K, Wang H, Li X, Wang Y, Huang L, Du Y, Qin N, Dong J, Wei J, Sun R, Shi Y, Guo Y, Sun X, Yang Y, Yang YG, Kan Q, Tian X
Clinical and translational medicine 2025 Mar;15(3):e70270
Clinical and translational medicine 2025 Mar;15(3):e70270
4-Octyl Itaconate Alleviates Myocardial Ischemia-Reperfusion Injury Through Promoting Angiogenesis via ERK Signaling Activation.
Yang J, Duan C, Wang P, Zhang S, Gao Y, Lu S, Ji Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(10):e2411554
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(10):e2411554
HAT1/HDAC2 mediated ACSL4 acetylation confers radiosensitivity by inducing ferroptosis in nasopharyngeal carcinoma.
Zhou P, Peng X, Zhang K, Cheng J, Tang M, Shen L, Zhou Q, Li D, Yang L
Cell death & disease 2025 Mar 6;16(1):160
Cell death & disease 2025 Mar 6;16(1):160
Neutrophil-derived heparin-binding protein increases endothelial permeability in acute lung injury by promoting TRIM21 and the ubiquitination of P65.
Zhang J, Cao Y, Shu W, Dong S, Sun Y, Ma X
Cell biology and toxicology 2025 Mar 5;41(1):55
Cell biology and toxicology 2025 Mar 5;41(1):55
CDC20 protects the heart from doxorubicin-induced cardiotoxicity by modulating CCDC69 degradation.
Feng Z, Zhang N, Wang L, Guan X, Xie Y, Xia YL
Cellular & molecular biology letters 2025 Mar 5;30(1):29
Cellular & molecular biology letters 2025 Mar 5;30(1):29
Lactylation increases the stability of RBM15 to drives m6A modification in non-small-cell lung cancer cells.
Zhao Z, Zhang Z, Cai Q, Yang R, Liang H, Qian B, Xiao B, Jiang Y, Wang L, Wang X, Cai J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Mar 31;39(6):e70493
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Mar 31;39(6):e70493
Designer polyQ fusion proteins sequester USP7/HDM2 for modulating P53 functionality.
Zhang XL, Yue HW, Liu YJ, Wang JY, Duan HT, Liu YH, Jiang LL, Hu HY
iScience 2025 Mar 21;28(3):112025
iScience 2025 Mar 21;28(3):112025
USP8 and Hsp70 regulate endoreplication by synergistically promoting Fzr deubiquitination and stabilization.
Qian W, Zhang X, Yuan D, Wu Y, Li H, Wei L, Li Z, Dai Z, Song P, Sun Q, Zhou Z, Xia Q, Cheng D
Science advances 2025 Mar 21;11(12):eadq9111
Science advances 2025 Mar 21;11(12):eadq9111
TRIM22 inhibits the metastasis of colorectal cancer through facilitating β-Catenin degradation.
Hu H, Li W, Ma P, Song J, Zhang X, Ruan L, Zhang J, Zheng Y
Experimental cell research 2025 Mar 15;446(2):114473
Experimental cell research 2025 Mar 15;446(2):114473
A novel mechanism in regulating drug sensitivity, growth, and apoptosis of bortezomib-resistant multiple myeloma cells: the USP4/KLF2/HMGA2 cascade.
Liu Z, Li X, He Y, Xie F, Zhang Y, Huang M, Wang Y, Zhu W
Journal of orthopaedic surgery and research 2025 Mar 1;20(1):220
Journal of orthopaedic surgery and research 2025 Mar 1;20(1):220
YTHDC1 promotes postnatal brown adipose tissue development and thermogenesis by stabilizing PPARγ.
Wang L, Wang Y, Ding K, Li Z, Zhang Z, Li X, Song Y, Xie L, Chen Z
The EMBO journal 2025 Jun;44(12):3360-3380
The EMBO journal 2025 Jun;44(12):3360-3380
Exosomal miR-196a-5p Secreted by Bone Marrow Mesenchymal Stem Cells Inhibits Ferroptosis and Promotes Drug Resistance of Acute Myeloid Leukemia.
Fan B, Wang L, Hu T, Zheng L, Wang J
Antioxidants & redox signaling 2025 Jun;42(16-18):933-953
Antioxidants & redox signaling 2025 Jun;42(16-18):933-953
Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression.
Ma Z, Xu Y, Lian P, Wu Y, Liu K, Zhang Z, Tang Z, Yang X, Cao X
Neuroscience bulletin 2025 Jun;41(6):951-969
Neuroscience bulletin 2025 Jun;41(6):951-969
Redox regulation of TRIM28 facilitates neuronal ferroptosis by promoting SUMOylation and inhibiting OPTN-selective autophagic degradation of ACSL4.
Liu W, Zhu Y, Ye W, Xiong J, Wang H, Gao Y, Huang S, Zhang Y, Zhou X, Zhou X, Ge X, Cai W, Zheng X
Cell death and differentiation 2025 Jun;32(6):1041-1057
Cell death and differentiation 2025 Jun;32(6):1041-1057
Suppression of NRF2 by photodynamic action to enhance bortezomib-triggered DNA damage for synergistic colorectal cancer therapy.
Li LG, Chen H, Yu TT, Liu RL, Kong C, Leng F, Xiao RC, Lu YH, Han N, Hu J, Hui YJ, Li TF
Journal of photochemistry and photobiology. B, Biology 2025 Jun;267:113162
Journal of photochemistry and photobiology. B, Biology 2025 Jun;267:113162
A bacterial RING ubiquitin ligase triggering stepwise degradation of BRISC via TOLLIP-mediated selective autophagy manipulates host inflammatory response.
Pan X, Sun Y, Liu J, Chen R, Zhang Z, Li C, Yao H, Ma J
Autophagy 2025 Jun;21(6):1353-1372
Autophagy 2025 Jun;21(6):1353-1372
Indole-3-carbinol inhibits PD-L1-mediated immune evasion in hepatocellular carcinoma via suppressing NF-κB p105 Ubiquitination.
Wu Y, Tao Q, Xie J, Liu X, Zhou Y, Wei C, Zhang C, Wang J, Jin Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156692
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156692
CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1-Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis.
Han J, Hong R, Cao C, Feng W, Zhuang W, Wang G, Tang J, Yang Y, Zhang C, Zhou A, Qu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2414550
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2414550
CIP2A promotes inflammation and exacerbates osteoarthritis by targeting CEMIP.
Su J, Sun X, Chen X, Wei K, Luo D, Yang S, Zhang C, Xu J, Deng Z
Cellular & molecular biology letters 2025 Jun 9;30(1):67
Cellular & molecular biology letters 2025 Jun 9;30(1):67
Lactate programs PBX1 lactylation and mesangial proliferation in lupus nephritis.
Liu E, Weng C, Yan C, Zhu X, Li X, Liu M, Wen Z, Liu Z
JCI insight 2025 Jun 9;10(11)
JCI insight 2025 Jun 9;10(11)
LMNB2-mediated high PD-L1 transcription triggers the immune escape of hepatocellular carcinoma.
Li Y, Zhu J, Zhai F, Ge Y, Zhan Z, Wang S, Kong L, Zhao J, Hu L, Wang S, Shi J, Mao J, Yu Z, Wang H, Jin J, Zhao M, Li H, Jin X
Cell death discovery 2025 Jun 7;11(1):269
Cell death discovery 2025 Jun 7;11(1):269
GART promotes multiple myeloma malignancy via tumor stemness mediated by activating the HSP90α/CDK6/β-catenin axis.
Qian J, Meng H, Wang Z, Sun Y, Xu X, Shi H, Wang C, Zhou L, Lv X, Yang Y, Gu C
European journal of pharmacology 2025 Jun 5;996:177584
European journal of pharmacology 2025 Jun 5;996:177584
ERK1-mediated GLYCTK2 phosphorylation promotes fructolysis to sustain glioblastoma survival under glucose deprivation.
Li Y, Zhang F, Hu F, Tong R, Wen Y, Fu G, Bian X
Cell death discovery 2025 Jun 4;11(1):266
Cell death discovery 2025 Jun 4;11(1):266
UBE3C promotes pancreatic ductal adenocarcinoma progression by catalysing p53 ubiquitination.
Shi Y, Wang J, Cheng Q, Wu S, Qin X, Yang Z
Molecular biology reports 2025 Jun 24;52(1):633
Molecular biology reports 2025 Jun 24;52(1):633
Cullin 3-mediated ubiquitination restricts enterovirus D68 replication and is counteracted by viral protease 3C.
Li Y, Qu L, Tang Y, Ni F, Shen S, Guo H, Yu X-F, Wei W
Journal of virology 2025 Jun 17;99(6):e0035425
Journal of virology 2025 Jun 17;99(6):e0035425
DTX2 attenuates Lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal β-oxidation in hepatocellular carcinoma.
Zhang Z, Zhou Q, Li Z, Huang F, Mo K, Shen C, Niu X, Hou B, Zhang C, Huang S
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2025 Jul;81:101224
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2025 Jul;81:101224
Inhibition of CDC27 O-GlcNAcylation coordinates the antitumor efficacy in multiple myeloma through the autophagy-lysosome pathway.
Wu HQ, Qin RC, Li WJ, Liu JN, Deng C, Zheng ZH, Zheng JP, Liu Y, Meng YF, Tang C, Tan HM, Duan FF, Tang Y, Xiao F, Lu LW, Dai XY, Ma KY
Acta pharmacologica Sinica 2025 Jul;46(7):2041-2055
Acta pharmacologica Sinica 2025 Jul;46(7):2041-2055
Non-classic deubiquitinase USP13 inhibits bladder cancer metastasis through destabilizing cytoplasmic KDM3A.
Hu H, Zhan X, Xiong Y, Yuan R, Du Y, Dong Q, Li S, Guo B, Li Z, Feng J, Xiong S, Xiong J, Li D, Fu B, Xu S, Guo J
Oncogene 2025 Jul;44(28):2372-2385
Oncogene 2025 Jul;44(28):2372-2385
COTE1 Regulates AMPKα2 Deubiquitination by Targeting WWP1 Activation to Promote Proliferation and Autophagy in Small Cell Lung Cancer.
Ma Y, Song B, Guo H, Chen Y, Cao C, Hao Y, Zheng Y, Li X
Journal of biochemical and molecular toxicology 2025 Jul;39(7):e70342
Journal of biochemical and molecular toxicology 2025 Jul;39(7):e70342
DSK2-mediated degradation of F-box protein LAO1 and class I TCPs modulates the nitrogen starvation response.
Li Y, Cheng S, Jin X, Wu R, Guo Y, Wu D, Dong J
EMBO reports 2025 Jul;26(14):3614-3639
EMBO reports 2025 Jul;26(14):3614-3639
OsbHLH062 negatively regulates Fe homeostasis by enhancing OsHRZ1 targeting OsPRIs for degradation.
Li C, Zhao J, Ping H, Li Y, Lei R, Pan B, Liang G
The New phytologist 2025 Jul;247(1):160-177
The New phytologist 2025 Jul;247(1):160-177
SARS-CoV-2 encoded ORF3a interacts with YY1 to promote latent HCMV reactivation.
Xia S, Huo X, Liu N, Liu X, Wang T, Guo M, Zeng C, Wan P, Chen J
PLoS pathogens 2025 Jul;21(7):e1013344
PLoS pathogens 2025 Jul;21(7):e1013344
Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration.
Tang Q, Tang K, Markby GR, Parys M, Phadwal K, MacRae VE, Corcoran BM
Autophagy 2025 Jul;21(7):1433-1455
Autophagy 2025 Jul;21(7):1433-1455
SIRT5 promotes the osteo-inductive potential of BMP9 by stabilizing the HIF-1α protein in mouse embryonic fibroblasts.
Liu L, Ye F, Jiang Y, Liu W, He D, He W, Gao X, Liu H, Liao J, He B, He F
Genes & diseases 2025 Jul;12(4):101563
Genes & diseases 2025 Jul;12(4):101563
Neoadjuvant Chemotherapy With Cisplatin Up-Regulates GSDMD to Enhance Oral Squamous Cell Carcinoma Metastasis Through MMP14-Mediated EMT Activation.
Huang Z, Jiang Q, Zhang Q, Lu N, Rui X, Chen R, Wang Y, Wang Y, Xu X, Huang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(25):e2501149
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(25):e2501149
Ubiquitin Specific Protease 9X Regulates the Activation of ARK5 and Promotes Progression of Fibrotic Remodeling.
Li X, Jiang S, Yang W, Zhu X, Zhang F, Li Z, Guo X, Wei Y
JACC. Basic to translational science 2025 Jul;10(7):101255
JACC. Basic to translational science 2025 Jul;10(7):101255
Deciphering the molecular mechanism of YY1/HIF1A modulating ovarian cancer angiogenesis based on single-cell transcriptomics technology.
Quan X, Yi H, Huang M, Chen D
Mutation research 2025 Jul-Dec;831:111916
Mutation research 2025 Jul-Dec;831:111916
Erdafitinib inhibits the tumorigenicity of MDA-MB-231 triple-negative breast cancer cells by inducing TRIM25/ubiquitin-dependent degradation of FGFR4.
Luo Q, Zhang L, Hao Y, Xu C, Wang X, Jia Z, Xie X, Huang Z, Gao X, Chen Y, Zhu X, Fang J, Wang K, Yin Y
Breast cancer research : BCR 2025 Jul 9;27(1):128
Breast cancer research : BCR 2025 Jul 9;27(1):128
YY1 enhances HIF-1α stability in tumor-associated macrophages to suppress anti-tumor immunity of prostate cancer in mice.
Li W, Chen S, Lu J, Mao W, Zheng S, Zhang M, Wu T, Chen Y, Lu K, Chu C, Shu C, Hou Y, Yang X, Shi N, Chen Z, Zhang L, Zhang L, Na R, Chen M, Ju S, Zhang D, Ma Y, Xu B
Nature communications 2025 Jul 7;16(1):6261
Nature communications 2025 Jul 7;16(1):6261
Aquaglyceroporin-7 ameliorates sorafenib resistance and immune evasion in hepatocellular carcinoma through inhibition of lipid accumulation.
He G, Shao W, Wang W, Sun L, Gao B, Wei J
Cellular and molecular life sciences : CMLS 2025 Jul 3;82(1):270
Cellular and molecular life sciences : CMLS 2025 Jul 3;82(1):270
Porcine reproductive and respiratory syndrome virus NSP5 exploited UBE2L6 to promote viral replication via antagonising host RLRs and ISGylation.
Zhu Z, Chen L, Zhang M, Lin Q, Yan Y, Wang W, Wen W, Zhang Z, Li X
Veterinary research 2025 Jul 3;56(1):136
Veterinary research 2025 Jul 3;56(1):136
Pantothenic acid ameliorates hepatic fibrosis by targeting IGFBP6 to regulate the TGF-β/SMADs pathway.
Jin Z, Jin Z, Liu Z, Yin Y, Zhang Y, Zhang Y, Kang J, Fang Y, Jiang W, Ning B
Communications biology 2025 Jul 29;8(1):1127
Communications biology 2025 Jul 29;8(1):1127
Genetic modulation of lncPSMB1 confers non-syndromic cleft lip with or without cleft palate susceptibility by promoting cell apoptosis.
Li X, Gao Y, Cheng T, Lin J, Lou S, Wang L, Mi C, Ding X, Du M, Pan Y
Communications biology 2025 Jul 29;8(1):1123
Communications biology 2025 Jul 29;8(1):1123
Renal tubular GSDME protects cisplatin nephrotoxicity by impeding OGT-STAT3-S100A7A axis in male mice.
Chen Q, Sun P, Zhou J, Long T, Xiao A, Liu Z, Xu S, Lei W, Zhang R, Tian J, Zhou M, Hu Z, Zhu F, Nie J
Nature communications 2025 Jul 24;16(1):6807
Nature communications 2025 Jul 24;16(1):6807
Cathepsin B deficiency disrupts cortical development via PEG3, leading to depression-like behavior.
Xie Z, Yang Q, Lan F, Kong W, Zhao S, Sun J, Yan Y, Quan Z, Bai Z, Qing H, Mao J, Ni J
Communications biology 2025 Jul 23;8(1):1097
Communications biology 2025 Jul 23;8(1):1097
Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice.
Wu Y, Zhang Y, Yu Y, Wang X, Zhen Z, Yuan Y, Xie B, Han M, Wang M, Zhang X, Sun X, Wen X, Hashimoto K, Shang Y, Yuan S, Zhang J
Nature communications 2025 Jul 23;16(1):6779
Nature communications 2025 Jul 23;16(1):6779
UBE4B promotes gastric cancer proliferation and metastasis by mediating FAT4 ubiquitination and degradation.
Wu K, Guo Z, Fu Y, Yang S, Pan Y, Yan R, Zhou X
Cell death & disease 2025 Jul 23;16(1):551
Cell death & disease 2025 Jul 23;16(1):551
ILF3 promotes colorectal cancer cell resistance to ferroptosis by enhancing cysteine uptake and GSH synthesis via stabilizing SLC3A2 mRNA.
Wang S, Zhu L, Wang Y, Han Y, Wang Q, Yang W, Zhao L, Zhang Y, Pei D, Huang W, Jin A, Lin Z, Piao J
Cell death & disease 2025 Jul 23;16(1):549
Cell death & disease 2025 Jul 23;16(1):549
circFTO binding with IGF2BP2 regulates trophoblast cells proliferation, migration, and invasion while mediating m6A modification of CCAR1 mRNA in spontaneous abortion.
Zhang Y, Wu M, Lin X, Lu B, Chen X, Li Q, Jiang Y, Li B, Zhou D, Sheng X
BMC molecular and cell biology 2025 Jul 2;26(1):21
BMC molecular and cell biology 2025 Jul 2;26(1):21
SIGLEC1 ubiquitination and degradation induced by MARCHF3 protects ARPE19 retinal cells from high glucose-induced oxidative stress, inflammation, and apoptosis.
Rong X, Jiang Y, Qi M, Gao W, Rao Y
International ophthalmology 2025 Jul 19;45(1):298
International ophthalmology 2025 Jul 19;45(1):298
Activated TBK1 promotes ACSL1-mediated microglia lipid droplet accumulation and neuroinflammation in Parkinson's disease.
Han C, Wang H, Zhang M, Wu L, Wang A, Yang P, Gao Y, Zhang C, Gao J, Xue T, Du T, Ji Y, Shi L, Zhang C, Li R, Xiao Y, Zhang J, Meng F
Journal of neuroinflammation 2025 Jul 19;22(1):190
Journal of neuroinflammation 2025 Jul 19;22(1):190
FXR acts as a therapeutic target for ulcerative colitis via suppressing ferroptosis.
Zhao C, Li X, Mu M, Quan L, Yuan H, Zheng J, Zhao W, Sun X, Yu J
Molecular medicine (Cambridge, Mass.) 2025 Jul 18;31(1):258
Molecular medicine (Cambridge, Mass.) 2025 Jul 18;31(1):258
Timosaponin AIII alleviates type 2 diabetes-induced cardiomyopathy by targeting galectin-3 (LGALS3).
Yin J, Yu C, Zhang Z, Cong J
Experimental cell research 2025 Jul 15;450(2):114665
Experimental cell research 2025 Jul 15;450(2):114665
Poldip2 Aggravates inflammation in diabetic retinopathy by impairing mitophagy via the AMPK/ULK1/Pink1 pathway.
Lin S, Ji Z, Gao J, Fan J, Hou J, Liu S, Wang C, Chen K, Tao L, Jiang Z
Life sciences 2025 Jul 15;373:123681
Life sciences 2025 Jul 15;373:123681
Pembrolizumab promotes degradation of cyclin dependent kinase 6 and suppresses ovarian cancer progression in vitro.
Wu Y, Xu Z, Kou Z, Ye Q, Chen L, Gou B
Scientific reports 2025 Jul 12;15(1):25283
Scientific reports 2025 Jul 12;15(1):25283
MTMR14 depletion aggravates intrapulmonary inflammation and emphysema in experimental COPD through activating macrophage M1 polarization.
Zhang J, Zhan Y, Deng Z, Chen S, Yang R, Zhang Y, Fu H, Huang Q, Wu J, Gu Y, Xie J
Respiratory research 2025 Jul 10;26(1):238
Respiratory research 2025 Jul 10;26(1):238
Trim65 mitigates doxorubicin-induced myocardial injury by reducing ferroptosis.
Ma X, Chen W, Hu Z, Xie L, Li Z, Liu H, Li Z, Jiang Z, Huang J, Jiang C, Huang K, Xiao S
Experimental cell research 2025 Jul 1;450(1):114613
Experimental cell research 2025 Jul 1;450(1):114613
USP7 promotes PINK1/Parkin-dependent mitophagy to ameliorate cerebral ischemia-reperfusion injury by deubiquitinating and stabilizing SIRT1.
Hou D, Hu Y, Yun T, Yu D, Yang G
Brain research 2025 Jul 1;1858:149638
Brain research 2025 Jul 1;1858:149638
Impact of N-acetyltransferase 10 on macrophage activation and inflammation-induced cardiac dysfunction.
Xiao Z, Wei X, Li P, Chen R, Yu Z, Liang Y, Su Y, Ge J
Cell death & disease 2025 Jul 1;16(1):471
Cell death & disease 2025 Jul 1;16(1):471
SLC44A2 negatively regulates mitochondrial fatty acid oxidation to suppress colorectal progression by blocking the MUL1-CPT2 interaction.
Yang Y, Zheng L, He J, Wu T, Yang H, Zhang B, Zhou S, Lu Y, He X, Li J, Wang N
Cell death & disease 2025 Jul 1;16(1):468
Cell death & disease 2025 Jul 1;16(1):468
E3 ligase TRIM22 promotes melanoma proliferation by regulating cell cycle progression through K63-linked ubiquitination of p21.
Jin CX, Feng TZ, Ji X, Liu YS, Qin HN, Teng YB, Sampson C, Xia T, Piao HL, Liu JW
Scientific reports 2025 Jul 1;15(1):22311
Scientific reports 2025 Jul 1;15(1):22311
Dehydrocostus lactone suppresses gastric cancer progression by targeting ACLY to inhibit fatty acid synthesis and autophagic flux.
Chen Y, Shen J, Yuan M, Li H, Li Y, Zheng S, Han B, Zhang C, Liu S, Sun Q, Wu J
Journal of advanced research 2025 Jan;67:331-348
Journal of advanced research 2025 Jan;67:331-348
LRRC45 accelerates bladder cancer development and ferroptosis inhibition via stabilizing NRF2 by competitively KEAP1 interaction.
Fan L, Guo D, Zhu C, Gao C, Wang Y, Yin F, Liu M, Zhou Y, Wei T, Xiong X, Yu K, Le A
Free radical biology & medicine 2025 Jan;226:29-42
Free radical biology & medicine 2025 Jan;226:29-42
USP7 facilitates deubiquitination of LRRC42 in colorectal cancer to accelerate tumorigenesis and augment Wnt/β-catenin signaling.
Li Y, Sun X, Huang Z
Biochimica et biophysica acta. Molecular cell research 2025 Jan;1872(1):119859
Biochimica et biophysica acta. Molecular cell research 2025 Jan;1872(1):119859
Vitamin K-dependent gamma-carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGFR.
Wu Z, Ye Q, Zhang S, Hu LP, Wang XQ, Yao LL, Zhu L, Xiao SY, Duan ZH, Zhang XL, Jiang SH, Zhang ZG, Liu DJ, Li DX, Yang XM
Clinical and translational medicine 2025 Jan;15(1):e70191
Clinical and translational medicine 2025 Jan;15(1):e70191
Inhibitory effects of circR-127aa on gastric cancer progression and tumor growth.
Qiao L, Pan W, Yang J, Cheng Y, Han Y, Zhu Q, Liu R, Zhang H, Ba Y
Cellular signalling 2025 Jan;125:111520
Cellular signalling 2025 Jan;125:111520
Revealing the Mechanism of Protein Degradation in Postmortem Meat: The Role of Phosphorylation and Ubiquitination.
Zhao X, Wu S, Ren C, Bai Y, Hou C, Li X, Wang Z, Zhang D
Foods (Basel, Switzerland) 2025 Jan 9;14(2)
Foods (Basel, Switzerland) 2025 Jan 9;14(2)
NEK8 promotes the progression of gastric cancer by reprogramming asparagine metabolism.
Wang M, Yu K, Meng F, Wang H, Li Y
Molecular medicine (Cambridge, Mass.) 2025 Jan 6;31(1):3
Molecular medicine (Cambridge, Mass.) 2025 Jan 6;31(1):3
TRIM38 Inhibits Zika Virus by Upregulating RIG-I/MDA5 Pathway and Promoting Ubiquitin-Mediated Degradation of Viral NS3 Protein.
He J, Kuang Y, Xu K, Huang R, Yang X, Deng L, Feng X, Ren Y, Yang J, Yuan L
Viruses 2025 Jan 30;17(2)
Viruses 2025 Jan 30;17(2)
Nuclear farnesoid X receptor protects against bone loss by driving osteoblast differentiation through stabilizing RUNX2.
Dong Q, Fu H, Li W, Ji X, Yin Y, Zhang Y, Zhu Y, Li G, Jia H, Zhang H, Wang H, Hu J, Wang G, Wu Z, Zhang Y, Xu S, Hou Z
Bone research 2025 Jan 30;13(1):20
Bone research 2025 Jan 30;13(1):20
Deciphering transcription activity of mammalian early embryos unveils on/off of zygotic genome activation by protein translation/degradation.
Zhang YR, Guo SM, Shi XY, Ding YW, Li HB, Li L, Xu JW, He X, Ma BX, Yin Y, Zhou LQ
Cell reports 2025 Jan 28;44(1):115215
Cell reports 2025 Jan 28;44(1):115215
A novel peptide encoded by circSRCAP confers resistance to enzalutamide by inhibiting the ubiquitin-dependent degradation of AR-V7 in castration-resistant prostate cancer.
Meng X, Wu Q, Cao C, Yang W, Chu S, Guo H, Qi S, Bai J
Journal of translational medicine 2025 Jan 23;23(1):108
Journal of translational medicine 2025 Jan 23;23(1):108
PLAC8 attenuates pulmonary fibrosis and inhibits apoptosis of alveolar epithelial cells via facilitating autophagy.
Sun W, Zhao B, He Z, Chang L, Song W, Chen Y
Communications biology 2025 Jan 14;8(1):48
Communications biology 2025 Jan 14;8(1):48
COPS5 regulates osteosarcoma progression by upregulating KHSRP to promote Per2 mRNA decay.
Bu J, Xu X, Luo Y, Liu J, Yao X
Experimental cell research 2025 Jan 1;444(1):114358
Experimental cell research 2025 Jan 1;444(1):114358
NUC7738 Induces Apoptosis Through Modulating Stability of P53 in Esophageal Cancer Cells.
Wu LF, Ren CH, Xu JC, Zhang YF, Liu YB, Zhou PH, Zhang YQ
Journal of biochemical and molecular toxicology 2025 Feb;39(2):e70175
Journal of biochemical and molecular toxicology 2025 Feb;39(2):e70175
Modulation of the local angiotensin II: Suppression of ferroptosis and radiosensitivity in nasopharyngeal carcinoma via the HIF-1α-HILPDA axis.
Huang X, Lin K, Chen W, Zhang D, Khan M, Ye X, Wang B, Chen C, Tian Y, Yuan Y, Lin J
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2025 Feb;203:110686
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2025 Feb;203:110686
METTL14-mediated m6A modification of ZFP14 inhibits clear cell renal cell carcinoma progression via promoting STAT3 ubiquitination.
Liu Z, Sun T, Zhang Z, Piao C, Kong C, Zhang X
Clinical and translational medicine 2025 Feb;15(2):e70232
Clinical and translational medicine 2025 Feb;15(2):e70232
N(6)-Methyladenosine modification mediated by METTL3 promotes DNA-PKcs expression to induce anlotinib resistance in osteosarcoma.
Zhang Y, Shen G, Zhang D, Meng T, Lv Z, Chen L, Li J, Li K
Clinical and translational medicine 2025 Feb;15(2):e70228
Clinical and translational medicine 2025 Feb;15(2):e70228
Targeting CDK2 Confers Vulnerability to Lenvatinib Via Driving Senescence in Anaplastic Thyroid Cancer.
Ma B, Sang Y, Du X, Zhang Y, Yin M, Xu W, Liu W, Lu J, Guan Q, Wang Y, Liao T, Wang Y, Xiang J, Shi R, Qu N, Ji Q, Zhang J, Ji D, Wang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2413514
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2413514
Ubiquitination of CD47 Regulates Innate Anti-Tumor Immune Response.
Gou Q, Yan B, Duan Y, Guo Y, Qian J, Shi J, Hou Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2412205
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2412205
HECW1-Mediated Ubiquitination of HIPK2 Drives Metastasis in Gastric Cancer Through the AKT Signaling Pathway.
Zhang G, Qu W, Huang X, Yi J, Gao H, He J, Xue W
Laboratory investigation; a journal of technical methods and pathology 2025 Feb;105(2):102202
Laboratory investigation; a journal of technical methods and pathology 2025 Feb;105(2):102202
RNF167 mediates atypical ubiquitylation and degradation of RLRs via two distinct proteolytic pathways.
He M, Yang Z, Xie L, Chen J, Liu S, Lu L, Li Z, Zheng B, Ye Y, Lin Y, Bu L, Xiao J, Zhong Y, Jia P, Li Q, Liang Y, Guo D, Li CM, Hou P
Nature communications 2025 Feb 24;16(1):1920
Nature communications 2025 Feb 24;16(1):1920
Identification of a Potent and Selective CDK9 Degrader as a Targeted Therapeutic Option for the Treatment of Small-Cell Lung Cancer.
Wang Y, Wang M, Ma L, Zhang Y, Jiao Y, Zhang S, Yang Y, Li J, Wei M, Cao S, Zhang K, Liu S, Yang G
Journal of medicinal chemistry 2025 Feb 13;68(3):2528-2550
Journal of medicinal chemistry 2025 Feb 13;68(3):2528-2550
Rack1 promotes breast cancer stemness properties and tumorigenesis through the E2F1-SOX2 axis.
Jia Y, Zhang L, Zhou W, Chen S, Zhang H, Liu L, Guo H, Wang Z, Cui Y, Niu R, Zhang F
Cancer cell international 2025 Feb 12;25(1):40
Cancer cell international 2025 Feb 12;25(1):40
FTO-associated osteoclastogenesis promotes alveolar bone resorption in apical periodontitis male rat via the HK1/USP14/RANK pathway.
Qian Y, Wu J, Yang W, Lyu R, You Q, Li J, He Q, Zhuang Y, Wang W, Wang Y, Zhu Y, Wu Z, Chen D
Nature communications 2025 Feb 11;16(1):1519
Nature communications 2025 Feb 11;16(1):1519
Non-catalytic mechanisms of KMT5C regulating hepatic gluconeogenesis.
Zhao Q, Cui X, Zhu Q, Li F, Bao R, Shi T, Liu H, Lv W, Xu Y, Gao Y, Tang QQ, Zhang M, Pan D
Nature communications 2025 Feb 10;16(1):1483
Nature communications 2025 Feb 10;16(1):1483
HDAC1-3 inhibition triggers NEDD4-mediated CCR2 downregulation and attenuates immunosuppression in myeloid-derived suppressor cells.
Xie Z, Shao J, Shen Z, Ye Z, Okada Y, Okuzaki D, Okada N, Tachibana M
Cancer immunology, immunotherapy : CII 2025 Feb 1;74(3):81
Cancer immunology, immunotherapy : CII 2025 Feb 1;74(3):81
The functional study of novel KLHL3 missense mutations associated with pseudohypoaldosteronism type II.
Zhang T, Liu Y, Li X, Xue K, Wu J, Lyu J
Endocrine 2025 Dec;90(3):1527-1534
Endocrine 2025 Dec;90(3):1527-1534
SIRT5 Facilitates Liver Steatosis Progression via Promoting SDH Desuccinylation During High-Fat Diet Feeding.
Liu Z, Hu J, Lin Y, Ge C, Shao Y, Bao M, Liu M, Jia S, Li Y, Xu X, Li R, Jiang Q, Yan F, Xiao F, Ye J
Liver international : official journal of the International Association for the Study of the Liver 2025 Dec;45(12):e70433
Liver international : official journal of the International Association for the Study of the Liver 2025 Dec;45(12):e70433
MARCH8/NSUN6/ROS-mediated DNA damage positive feedback loop regulates cisplatin resistance in osteosarcoma.
He M, Li T, Wang A, Liu Y, Wang X, Liu Z, Xie J, Wang Y, Wang Y, Ren Z, Ge S, Yang L, Yuan Y
Cell death and differentiation 2025 Dec;32(12):2412-2426
Cell death and differentiation 2025 Dec;32(12):2412-2426
Mechanism of NUMBL enhancing axitinib resistance in clear cell renal cell carcinoma by UCHL1-mediated deubiquitination of MMP9.
Wang Z, Chen L, Zhang H, Yan Z, Liu K, Qi J, Lu B, Yin Y, Zhao C, Niu Y, Li W
The Journal of biological chemistry 2025 Dec;301(12):110873
The Journal of biological chemistry 2025 Dec;301(12):110873
Astragalus Polysaccharide Enhances O-GlcNAcylation Through OGT to Improve Intervertebral Disc Degeneration in Rats.
Tan H, Fang C, Tan Y, Wang Z, Zhou Y, Li X
Journal of cellular and molecular medicine 2025 Dec;29(23):e70940
Journal of cellular and molecular medicine 2025 Dec;29(23):e70940
CRIP1 exacerbates osteoarthritis progression by recruiting UBE3A to induce the ubiquitination-mediated degradation of MFGE8.
Li Y, Cheng C, Li M, Hou Y, Li J, Duan S, Gao E, Liu K, Dai Z
Biochemical pharmacology 2025 Dec;242(Pt 4):117407
Biochemical pharmacology 2025 Dec;242(Pt 4):117407
Tauroursodeoxycholic acid ameliorates palmitic acid induced endoplasmic reticulum stress and impaired autophagy via IRE1- XBP1-FoxO1 pathway in KGN cells.
Cao M, Qiao F, Wang Q, Luo J, Ju Y, Wang X, Chen X
Biochemical pharmacology 2025 Dec;242(Pt 4):117377
Biochemical pharmacology 2025 Dec;242(Pt 4):117377
Overcoming ELDR-mediated cancer cell survival in vitro and in vivo via sphingomyelin-driven TRPML1 inactivation and TFEB suppression through lysosomal HSP70 targeting.
Chen H, Zhu M, Zhao Z, Jiang Y, Wang H, Liu Y, Chen Y, Li H, Xun C, Hui H
Pharmacological research 2025 Dec;222:108050
Pharmacological research 2025 Dec;222:108050
1,8-Cineole ameliorates vascular endothelial senescence in diabetes mellitus by directly targeting and deubiquitinating PPAR-γ in vivo and in vitro.
Fu L, Tai S, Liao J, Du Y, Zhang G, Guo D, Chen X, Zheng T, Hu X, Yao W, Tao L, Wang X, Xu Y, Shen X
Journal of pharmaceutical analysis 2025 Dec;15(12):101307
Journal of pharmaceutical analysis 2025 Dec;15(12):101307
Bax inhibitor-1 like (CmoBI1L) functions in pumpkin salt tolerance by stabilizing Na(+) transporters and modulating the transcription of peroxidases.
Wei L, Luo S, Wang T, Xue S, Wang Y, Bie Z
The Plant journal : for cell and molecular biology 2025 Dec;124(5):e70595
The Plant journal : for cell and molecular biology 2025 Dec;124(5):e70595
Homocysteine Exacerbates Pulmonary Fibrosis via Orchestrating Syntaxin 17 Homocysteinylation of Alveolar Type II Cells.
Huang J, Fang K, Lu W, Wu R, Chen Y, Li L, Hu Z, Cai Z, Jiang Y, Fan X, Deng J, Liu G, Luo Z, Cui L, Li S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(46):e07803
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(46):e07803
UBE2M inhibits neoplastic cell proliferation via MKK7-JNK-EGR1 axis in melanoma.
Xu L, Pan C, Wang Y, Ni L, Zeng P, Lin X, Lyu X, Huang S, Dang N
Journal of translational medicine 2025 Dec 8;24(1):52
Journal of translational medicine 2025 Dec 8;24(1):52
Lysophosphatidylethanolamine 18:1 drives clear cell renal cell carcinoma by stabilizing SIRT6 to reprogram lipid metabolism.
Yue N, Zhao H, Zhang Y, Gu J, Qi J, Wen J, Wang W, Lv M, Sun H, Chen J, Yang C, Qu C, Chen X, Yang Z
Signal transduction and targeted therapy 2025 Dec 8;10(1):398
Signal transduction and targeted therapy 2025 Dec 8;10(1):398
STUB1-mediated PGC-1α ubiquitination promotes postoperative cognitive dysfunction in aged mice via modulating autophagy-lysosome machinery.
Shen QH, Xia JY, Ma Y, Xu SS
European journal of medical research 2025 Dec 30;31(1):173
European journal of medical research 2025 Dec 30;31(1):173
Lathyrol Exerts Anti-Pulmonary Fibrosis Effects by Activating PPARγ to Inhibit the TGF-β/Smad Pathway.
Zeng Q, Liao ML, Luo YY, Li S, You G, Huang CM, Liu MH, Liu W, Tang SY
International journal of molecular sciences 2025 Dec 30;27(1)
International journal of molecular sciences 2025 Dec 30;27(1)
LRRC1 Promotes Angiogenesis Through Regulating AKT/GSK3β/β-Catenin/VEGFA Signaling Pathway in Hepatocellular Carcinoma.
Liu H, Liu Z, Xie P, Liu Z, Zhang Y, Cao L, Shang N, Chen M, Feng H, Guan X, Dai G
Cells 2025 Dec 3;14(23)
Cells 2025 Dec 3;14(23)
Decitabine promotes degradation of DNMT1 and EZH2 via the ubiquitination pathway and inhibits colorectal cancer progression.
Peng XM, Shi XP, Chen H, Cao LY, Zuo HJ, Guo JQ, Jiang N, Luo XY
Cellular oncology (Dordrecht, Netherlands) 2025 Dec 29;49(1):9
Cellular oncology (Dordrecht, Netherlands) 2025 Dec 29;49(1):9
Liquid-liquid phase separation of ATXN2L enhances mRNA translation in hepatocellular carcinoma.
Wang S, Guo P, Ma W, Huang H, Zhang Q, Wolczynski S, Rahman N, Liu J, Tsang SY, Du X, Wang F, Gao J, Li X
Cell reports 2025 Dec 23;44(12):116588
Cell reports 2025 Dec 23;44(12):116588
TRIM16 mediates YAP1 K63-linked ubiquitination to alleviate sepsis-induced acute liver injury through YAP/Nrf2 axis in mice.
Zhang K, Liu M, Zheng Y, Gao Z, Dong Z, You M, Guo Y, Liang F, Zhao Z
Cell & bioscience 2025 Dec 23;16(1):7
Cell & bioscience 2025 Dec 23;16(1):7
Exploratory Analysis of Autophagy-Lysosomal Pathway Proteins in Dermal Fibroblasts as Potential Peripheral Biomarkers for Alzheimer's Disease: A Pilot Study.
Lee MS, Son SJ, Kim J, Go S, Hong CH, Roh HW, Chang J
Biomedicines 2025 Dec 23;14(1)
Biomedicines 2025 Dec 23;14(1)
FLASH-AWAY: Intrabody-Directed Targeting of Optogenetic Tools for Protein Degradation.
Zhuang Z, Li R, Wang B, Meng Y, Li Y, Nan J, Zhao X, Jing J
ACS synthetic biology 2025 Dec 19;14(12):4663-4674
ACS synthetic biology 2025 Dec 19;14(12):4663-4674
RNF152-mediated, ubiquitin-dependent degradation of HSP27 activates the PI3K/AKT pathway, driving synovial inflammatory cascades in TMJOA.
Zhang X, Jiang Q, Deng W, Tang H, Liu Y, Xu Z, Guo K, Liu N, Wang H, Cui T, Wang F, Qiu J
Arthritis research & therapy 2025 Dec 18;28(1):16
Arthritis research & therapy 2025 Dec 18;28(1):16
WWP2-induced inhibition of hepatocellular carcinoma cellular senescence via the ubiquitination and degradation of p21.
Chen X, Wang J, Yan Z, Du X, Zhang Z, Liu X, Hu L, He K, Zhang J, Han Y
Cell death & disease 2025 Dec 12;17(1):96
Cell death & disease 2025 Dec 12;17(1):96
FBXW7 regulates MAP7 through ubiquitination to affect the phenotypic characteristics and paclitaxel sensitivity of paclitaxel-resistant lung adenocarcinoma cells.
Zhang Y, Xu J, Sun W, Wei B, Zou J
European journal of medical research 2025 Dec 11;30(1):1230
European journal of medical research 2025 Dec 11;30(1):1230
Inhibitors of the 20S proteasome β5 subunit as potent and selective agents against Trichomonas vaginalis.
Miyamoto Y, Hurysz BM, Fajtova P, Eckmann P, Serafim MSM, Kronenberger T, Al-Hindy M, Dekker PM, Maurits E, Overkleeft HS, Bergdahl BM, Almaliti J, Gerwick WH, O'Donoghue AJ, Eckmann L
Antimicrobial agents and chemotherapy 2025 Dec 10;69(12):e0089325
Antimicrobial agents and chemotherapy 2025 Dec 10;69(12):e0089325
Upregulation of E3 ligase UBR2 in acetaldehyde-treated C2C12 myotubes and its potential involvement in fast-twitch muscle atrophy in alcohol-fed rats.
Shintani-Ishida K, Ikegaya H
Alcohol, clinical & experimental research 2025 Aug;49(8):1667-1677
Alcohol, clinical & experimental research 2025 Aug;49(8):1667-1677
KLX ameliorates liver cancer progression by mediating ZBP1 transcription and ubiquitination and increasing ZBP1-induced PANoptosis.
Wang Z, Yang Y, Yao FT, Zhang F, Lin KY, Diao HT, Zhao QY, Kong X, Si W, Xie YT, Song JL, Zeng LH, Wang CL, Xiong YT, Zou KK, Wang XM, Zhang XY, Wu H, Jiang WT, Bian Y, Yang BF
Acta pharmacologica Sinica 2025 Aug;46(8):2282-2295
Acta pharmacologica Sinica 2025 Aug;46(8):2282-2295
Otubain 2 stabilizes TNF‑receptor associated factor 3 to accelerate bone fracture healing.
Zhang L, Guo J, Feng S, Zheng Y, Wang H, Ma H, Chen W, Zhang Y, Hou Z
Molecular medicine reports 2025 Aug;32(2)
Molecular medicine reports 2025 Aug;32(2)
A novel designed fully peptide-based PROTAC, FPP29, demonstrates its potent cytotoxic effects to liver cancer HCCLM3 cells by targeting FOXM1.
Jia S, Qi H, Shang Z, Hua X, Liang A, Tian Y, Wu D, Jiang Y, Liu X, Mao C
Bioorganic chemistry 2025 Aug;163:108626
Bioorganic chemistry 2025 Aug;163:108626
Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis.
Yan J, Wang T, Yu R, Xu L, Shao H, Li T, Wang Z, Cha X, Miao Z, Xing C, Xu K, Liu H, Zhuang C
Acta pharmaceutica Sinica. B 2025 Aug;15(8):4137-4155
Acta pharmaceutica Sinica. B 2025 Aug;15(8):4137-4155
USP5-Rich Apoptotic Extracellular Vesicles Regulate Nucleus Pulposus Cells Apoptosis and DNA Damage Repair by Preventing E2F1 Proteasomal Degradation.
Shi P, Gao H, Cheng Z, Wu W, Zhang A, Chen X, Wu W, Zhang Y
Journal of extracellular vesicles 2025 Aug;14(8):e70148
Journal of extracellular vesicles 2025 Aug;14(8):e70148
Circ847 upregulation via CAFs suppresses salivary adenoid cystic carcinoma progression through VIM-EMT.
Liang Y, Zhou Y, Xu T, Wang Y, Xu X, Chen R, Jiang Q, Lu N, Zhao L, Huang Z, Huang Z
Cellular signalling 2025 Aug;132:111806
Cellular signalling 2025 Aug;132:111806
Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8-AS1/GPX4 Axis in Intrahepatic Cholangiocarcinoma.
Chen ZW, Shan JJ, Chen M, Wu Z, Zhao YM, Zhu HX, Jin X, Wang YX, Wu YB, Xiang Z, Ding ZW, Lin ZH, Wang LR, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(30):e01042
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(30):e01042
Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia-Inducible Factor-1 Signaling Pathway.
Zhao LN, Wang RL, Liu RX, Zheng MR, Zhao L, Li BF, Li JL, Liu DS, He XX, Peng QB, Li K, Lin TX, Liu YY, He SP, Lu J, Zheng SY, Liu X, Huang FZ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e17128
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e17128
Teniposide Triggers DNA Repair Inhibition by Binding and Ubiquitination of Apurinic/Apyrimidinic Endonuclease 1 to Boost Oxidative DNA Damage for Lung Cancer Destruction.
Han N, Hu J, Xie ZX, Zhang L, Li LG, Yu XR, Kong C, Leng F, Hu C, Zhang Q, Wang MF, Li TF
ACS pharmacology & translational science 2025 Aug 8;8(8):2710-2724
ACS pharmacology & translational science 2025 Aug 8;8(8):2710-2724
Machine learning-based proteomics profiling of ALS identifies downregulation of RPS29 that maintains protein homeostasis and STMN2 level.
Xu W, Guo Z, Guan Y, Lv S, Gao X, Luo W, Cheng T, Shao Z, Tao B, Wang T, Qiu Z
Communications biology 2025 Aug 7;8(1):1177
Communications biology 2025 Aug 7;8(1):1177
Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis.
Ma Q, Wang S, Xue H, Ni L, Yuan P, Shen Y, Zheng B, Wang Q, Zhang J, Wang H, Xie H, Jiang C, Qin A, Fan S, Xie Z, Jie Z
Nature communications 2025 Aug 6;16(1):7228
Nature communications 2025 Aug 6;16(1):7228
Targeting the SYVN1-EGFR axis: a breakthrough strategy for TKI-resistant NSCLC.
Xie X, Tong W, Xie Y, Jiang H, Jiang A, Huang J, Liu Z, Yu J
Cell death & disease 2025 Aug 28;16(1):655
Cell death & disease 2025 Aug 28;16(1):655
Nascent liver proteome reveals enzymes and transcription regulators under physiological and alcohol exposure conditions.
Gu J, Lao L, Hu L, Zang J, Liu C, Wan R, Tang L, Yuan Y, Chen Y, Lin S
Nature communications 2025 Aug 26;16(1):7945
Nature communications 2025 Aug 26;16(1):7945
NR3C1/GLMN-Mediated FKBP12.6 Ubiquitination Disrupts Calcium Homeostasis and Impairs Mitochondrial Quality Control in Stress-Induced Myocardial Damage.
Cong J, Liu L, Shi R, He M, An Y, Feng X, Yin X, Li Y, Cong B, Shi W
International journal of molecular sciences 2025 Aug 25;26(17)
International journal of molecular sciences 2025 Aug 25;26(17)
CX26 promotes pancreatic cancer progression by competitively inhibiting interaction of c-Myc with PSMD2 and enhancing c-Myc stability.
He C, Tang C, Guo J, Yin X, Zhu Q, Fang C
Journal of translational medicine 2025 Aug 19;23(1):939
Journal of translational medicine 2025 Aug 19;23(1):939
Oroxin A suppresses colorectal tumor growth by regulating the TRIM24-mediated ferroptosis and TSPO pathway.
He C, Weng C, Lai Z, Luo H, Chen K, Li T, Li W, Li G
iScience 2025 Aug 15;28(8):113196
iScience 2025 Aug 15;28(8):113196
Synthesis of USP5-IN-1 derivatives as novel USP5 inhibitors with potent activity against cholangiocarcinoma cells.
Hu X, Yu Z, Zhu H, Cui H, Ning F, Dai J, Zhang J, Li Y, Zhang X
Bioorganic & medicinal chemistry 2025 Aug 15;126:118213
Bioorganic & medicinal chemistry 2025 Aug 15;126:118213
SKP2 ubiquitylation modifies IDH1 to regulate hepatoblastoma cell cycle and glucose metabolism.
Yu P, Li J, Feng W, Lei T, Jia W, He Y, Bi Y
BMC cancer 2025 Aug 11;25(1):1304
BMC cancer 2025 Aug 11;25(1):1304
Tobacco Smoking Rewires Cell Metabolism by Inducing GAPDH Succinylation to Promote Lung Cancer Progression.
Wang K, Li J, Zhang H, Ma H, Cui HY, Ju HQ, Zhang J, Ma QZ, Zhao M, Zeng QM, Zou J, Sun XX, Nan G, Qian M, Jing L, Li Y, Xiong CF, Yang QZ, Wang H, Jiang JL, Chen ZN, Chen L, Huang W
Cancer research 2025 Aug 1;85(15):2838-2857
Cancer research 2025 Aug 1;85(15):2838-2857
Quercetin alleviates LPS/iE-DAP-induced liver injury by suppressing ferroptosis via regulating ferritinophagy and intracellular iron efflux.
Zhang H, Shi H, Li X, Zhou S, Song X, Ma N, Meng M, Chang G, Shen X
Redox biology 2025 Apr;81:103557
Redox biology 2025 Apr;81:103557
PLEKHA4 knockdown induces apoptosis in melanoma cells through the MAPK and β‑catenin signaling pathways.
Yue Y, An G, Cao S, Li X, Du L, Xu D, Liu L
Molecular medicine reports 2025 Apr;31(4)
Molecular medicine reports 2025 Apr;31(4)
Long noncoding RNA USP30-AS1 promotes influenza A virus replication by enhancing PHB1 function.
Yu X, Su N, Luo J, Zhang D, Zhang H, Duan M, Shi N
Veterinary microbiology 2025 Apr;303:110444
Veterinary microbiology 2025 Apr;303:110444
NLRC3 affects the development of psoriasis by modulating the NF-κB signaling pathway mediated inflammatory response through its interaction with TRAF6.
Zhang W, Zhu G, Sun H, Jiang C
Immunology letters 2025 Apr;272:106949
Immunology letters 2025 Apr;272:106949
CKAP4 in hepatocellular carcinoma: competitive RETREG1/FAM134B binding, reticulophagy regulation, and cancer progression.
Mo J, Su C, Li P, Yang Z, Tao R, Liu Q, Yuan C, Xu L, Ge Q, Ning D, Liang H, Zhu H, Luo Y, Chen X, Chen J, Zhang B
Autophagy 2025 Apr;21(4):840-859
Autophagy 2025 Apr;21(4):840-859
USP4 depletion-driven RAB7A ubiquitylation impairs autophagosome-lysosome fusion and aggravates periodontitis.
Kang S, Liu S, Dong X, Li H, Qian Y, Dai A, He W, Li X, Chen Q, Wang H, Ding PH
Autophagy 2025 Apr;21(4):771-788
Autophagy 2025 Apr;21(4):771-788
SAE1 promotes tumor cell malignancy via SUMOylation and liquid-liquid phase separation facilitated nuclear export of p27.
Wang L, Min J, Qian J, Huang X, Yu X, Cao Y, Sun S, Ke M, Lv X, Su W, Guo M, Li N, Qi S, Huang H, Gu C, Yang Y
Acta pharmaceutica Sinica. B 2025 Apr;15(4):1991-2007
Acta pharmaceutica Sinica. B 2025 Apr;15(4):1991-2007
Bruceine A Inhibits Cell Proliferation by Targeting the USP13/PARP1 Signalling Pathway in Multiple Myeloma.
Guo M, Meng H, Sun Y, Zhou L, Hu T, Yu T, Bai H, Zhang Y, Gu C, Yang Y
Basic & clinical pharmacology & toxicology 2025 Apr;136(5):e70027
Basic & clinical pharmacology & toxicology 2025 Apr;136(5):e70027
LINC00323 knockdown suppresses the proliferation, migration, and vascular mimicry of non-small cell lung cancer cells by promoting ubiquitinated degradation of AKAP1.
Ke B, Zhong H, Gong Y, Chen X, Yan C, Shi L
Non-coding RNA research 2025 Apr;11:131-140
Non-coding RNA research 2025 Apr;11:131-140
TCDD inhibits the proliferation of C17.2 cells through the activation of the c-Cbl/β-catenin signaling pathway.
Cong Y, Wu Y, Liu Y, Ai Y, Wang X, Wei C, Ding H, Xu G, Sun W
Toxicology in vitro : an international journal published in association with BIBRA 2025 Apr;104:106014
Toxicology in vitro : an international journal published in association with BIBRA 2025 Apr;104:106014
Cannabidiol Enhances the Anticancer Activity of Etoposide on Prostate Cancer Cells.
Erzurumlu Y, Catakli D
Cannabis and cannabinoid research 2025 Apr;10(2):258-276
Cannabis and cannabinoid research 2025 Apr;10(2):258-276
Plant salicylic acid signaling is inhibited by a cooperative strategy of two powdery mildew effectors.
Liu Y, Li X, He Q, Zuo M, Guo Y, Liu L, Yin J, He L, Li X, Shan J, Liu W, Lin C, Miao W
mBio 2025 Apr 9;16(4):e0395924
mBio 2025 Apr 9;16(4):e0395924
ELANE enhances KEAP1 protein stability and reduces NRF2-mediated ferroptosis inhibition in metabolic dysfunction-associated fatty liver disease.
Yang Q, Shen X, Luo Y, Li R, Meng X, Xu P, Liu X, Bian D, Wang J, Shi J, Chen J
Cell death & disease 2025 Apr 9;16(1):266
Cell death & disease 2025 Apr 9;16(1):266
Endothelial USP11 drives VEGFR2 signaling and angiogenesis via PRDX2/c-MYC axis.
Chen C, Chen Z, Luo R, Tu W, Long M, Liang M, Cheng M, Wang Z, Huang K, Wang C
Angiogenesis 2025 Apr 8;28(2):23
Angiogenesis 2025 Apr 8;28(2):23
The Role and Mechanism of TRIM13 Regulation of TRAF6 Ubiquitination in the Synergy of Inflammatory Responses and Neurotoxicity Induced by METH and HIV- 1 Tat Protein in Astrocytes.
Tan Y, Miao L, Wang C, Wang H, Li Y, Huang Y, Teng H, Tian Y, Yang G, Zeng X, Li J
Neurotoxicity research 2025 Apr 7;43(2):21
Neurotoxicity research 2025 Apr 7;43(2):21
SIRT5-mediated BCAT1 desuccinylation and stabilization leads to ferroptosis insensitivity and promotes cell proliferation in glioma.
Wang T, Han XH, Chen JJ, Wang X, Zhang Z, Han XJ, Lu Z
Cell death & disease 2025 Apr 7;16(1):261
Cell death & disease 2025 Apr 7;16(1):261
Trifluridine/tipiracil induces ferroptosis by targeting p53 via the p53-SLC7A11 axis in colorectal cancer 3D organoids.
Huang M, Wu Y, Wei X, Cheng L, Fu L, Yan H, Wei W, Li B, Ru H, Mo X, Tang W, Su Z, Yan L
Cell death & disease 2025 Apr 5;16(1):255
Cell death & disease 2025 Apr 5;16(1):255
USP2-induced upregulation of LEF1 through deubiquitination relieves osteoporosis development by promoting the osteogenic differentiation of bone marrow mesenchymal stem cells.
Zhang Z, Cao J, Xing H, Liu J, Li L, Zhang Y
Journal of orthopaedic surgery and research 2025 Apr 29;20(1):430
Journal of orthopaedic surgery and research 2025 Apr 29;20(1):430
PYK2 promotes cell proliferation and epithelial-mesenchymal transition in endometriosis by phosphorylating Snail1.
Liu L, Liu L, Yue C, Du S, Liu J, Yu Z
Molecular medicine (Cambridge, Mass.) 2025 Apr 27;31(1):155
Molecular medicine (Cambridge, Mass.) 2025 Apr 27;31(1):155
Glucosidase alpha neutral C promotes influenza virus replication by inhibiting proteosome-dependent degradation of hemagglutinin.
Liao X, Xie Q, Liang M, Liao Q, Huang B, Zhang S, Zhang F, Wang L, Yuan L, Liu X, Wen S, Luo C, Wang D, Chen Y, Luo H, Shu Y
Signal transduction and targeted therapy 2025 Apr 23;10(1):131
Signal transduction and targeted therapy 2025 Apr 23;10(1):131
Y4 RNA fragment alleviates myocardial injury in heart transplantation via SNRNP200 to enhance IL-10 mRNA splicing.
Lu C, Meng Z, Tang S, Wei H, Hu Y, Chen D, Liu D, Wen H, Dong K, Na N, Huang F, Zeng Z
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Apr 2;33(4):1735-1748
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Apr 2;33(4):1735-1748
TMEM160 inhibits KEAP1 to suppress ferroptosis and induce chemoresistance in gastric cancer.
Huang C, Zeng Q, Chen J, Wen Q, Jin W, Dai X, Ruan R, Zhong H, Xia Y, Wu Z, Huang R, Zhang J, Yao Y, Li L, Lei W, Xiong J, Deng J
Cell death & disease 2025 Apr 13;16(1):287
Cell death & disease 2025 Apr 13;16(1):287
CircPRKCA facilitates esophageal squamous cell carcinoma metastasis via m5C-dependent CSF2 mRNA stabilization.
Wu L, Gu L, Zheng Y, Liu J, Wei Z, Liu F, Li J, Meng L, Sang Y, Sang M, Zhao L, Shan B
Journal of translational medicine 2025 Apr 1;23(1):385
Journal of translational medicine 2025 Apr 1;23(1):385
Berberine Alleviates Ischemic Brain Injury by Enhancing Autophagic Flux via Facilitation of TFEB Nuclear Translocation.
Liu YL, Guo T, Zhang YJ, Tang SC, Zhao XM, He HY, Yu CL, Deng YH
The American journal of Chinese medicine 2024;52(1):231-252
The American journal of Chinese medicine 2024;52(1):231-252
O-GlcNAcylated RALY Contributes to Hepatocellular Carcinoma Cells Proliferation by Regulating USP22 mRNA Nuclear Export.
Liu S, Lv Q, Mao X, Dong H, Xu W, Du X, Jia W, Feng K, Zhang J, Zhang Y
International journal of biological sciences 2024;20(9):3675-3690
International journal of biological sciences 2024;20(9):3675-3690
The m6A modification-mediated positive feedback between glycolytic lncRNA SLC2A1-DT and c-Myc promotes tumorigenesis of hepatocellular carcinoma.
Zeng Z, Wang J, Xu F, Hu P, Hu Y, Zhuo W, Chen D, Han S, Wang F, Zhao Y, Huang Y, Zhao G
International journal of biological sciences 2024;20(5):1744-1762
International journal of biological sciences 2024;20(5):1744-1762
Mechanistic study of celastrol-mediated inhibition of proinflammatory activation of macrophages in IgA nephropathy via down-regulating ECM1.
Zhao J, Liu H, Chen Q, Xia M, Wan L, Yu W, Liu C, Hao X, Tang C, Chen G, Liu Y, Yuan F, Liu H
International journal of biological sciences 2024;20(14):5731-5746
International journal of biological sciences 2024;20(14):5731-5746
HSPD1 Supports Osteosarcoma Progression through Stabilizing ATP5A1 and thus Activation of AKT/mTOR Signaling.
Zhang Y, Pan R, Li K, Cheang LH, Zhao J, Zhong Z, Li S, Wang J, Zhang X, Cheng Y, Zheng X, He R, Wang H
International journal of biological sciences 2024;20(13):5162-5190
International journal of biological sciences 2024;20(13):5162-5190
Vaginal Tritrichomonas foetus infection in mice as an in vivo model for drug development against Trichomonas vaginalis.
Nieskens NM, Miyamoto Y, Hurysz BM, O'Donoghue AJ, Eckmann L
PloS one 2024;19(10):e0308672
PloS one 2024;19(10):e0308672
α-Synuclein-mediated mitochondrial translocation of cofilin-1 leads to oxidative stress and cell apoptosis in PD.
Yan M, Zhang Q, Chen Y, Zhu C, Wang D, Tan J, He B, Li Q, Deng X, Wan Y
Frontiers in neuroscience 2024;18:1420507
Frontiers in neuroscience 2024;18:1420507
Ubiquitination contributes to the regulation of GDP-mannose pyrophosphorylase B activity.
Franzka P, Mittag S, Chakraborty A, Huber O, Hübner CA
Frontiers in molecular neuroscience 2024;17:1375297
Frontiers in molecular neuroscience 2024;17:1375297
USP50 regulates NLRP3 inflammasome activation in duodenogastric reflux-induced gastric tumorigenesis.
Zhao C, Mu M, Li X, Dong Z, Wang J, Yao C, Zheng J, Sun X, Yu J
Frontiers in immunology 2024;15:1326137
Frontiers in immunology 2024;15:1326137
Abnormal mitochondrial iron metabolism damages alveolar type II epithelial cells involved in bleomycin-induced pulmonary fibrosis.
Shao M, Cheng H, Li X, Qiu Y, Zhang Y, Chang Y, Fu J, Shen M, Xu X, Feng D, Han Y, Yue S, Zhou Y, Luo Z
Theranostics 2024;14(7):2687-2705
Theranostics 2024;14(7):2687-2705
Photoreceptor-targeted extracellular vesicles-mediated delivery of Cul7 siRNA for retinal degeneration therapy.
Guo D, Sun Y, Wu J, Ding L, Jiang Y, Xue Y, Ma Y, Sun F
Theranostics 2024;14(13):4916-4932
Theranostics 2024;14(13):4916-4932
GSDMD suppresses keratinocyte differentiation by inhibiting FLG expression and attenuating KCTD6-mediated HDAC1 degradation in atopic dermatitis.
Zhong Y, Huang T, Li X, Luo P, Zhang B
PeerJ 2024;12:e16768
PeerJ 2024;12:e16768
LACTB suppresses liver cancer progression through regulation of ferroptosis.
Zeng K, Huang N, Liu N, Deng X, Mu Y, Zhang X, Zhang J, Zhang C, Li Y, Li Z
Redox biology 2024 Sep;75:103270
Redox biology 2024 Sep;75:103270
The mechanism of RGS5 regulating gastric cancer mismatch repair protein.
Yang Z, Zhang R, Liu J, Tian S, Zhang H, Zeng L, Zhang Y, Gao L, Wang M, Shan W, Liu J
Molecular carcinogenesis 2024 Sep;63(9):1750-1767
Molecular carcinogenesis 2024 Sep;63(9):1750-1767
USP18 Stabilized FTO Protein to Activate Mitophagy in Ischemic Stroke Through Repressing m6A Modification of SIRT6.
Song M, Yi F, Zeng F, Zheng L, Huang L, Sun X, Huang Q, Deng J, Wang H, Gu W
Molecular neurobiology 2024 Sep;61(9):6658-6674
Molecular neurobiology 2024 Sep;61(9):6658-6674
LUCAT1 Activates the Malignant Phenotypes of Lung Cancer Cells via Regulating P53 Ubiquitination.
Zhang J, Gong W, Wang X, Yang L
Iranian journal of public health 2024 Sep;53(9):2049-2058
Iranian journal of public health 2024 Sep;53(9):2049-2058
Increased CCT5 expression is a potential unfavourable factor promoting the growth of nasopharyngeal carcinoma.
Wu S, Peng L
The Journal of international medical research 2024 Sep;52(9):3000605241271754
The Journal of international medical research 2024 Sep;52(9):3000605241271754
Phosphorylation of RasGRP1 by Shc3 prevents RasGRP1 degradation and contributes to Ras/c-Jun activation in hepatocellular carcinoma.
Zhang X, Liu Y, Yang R, Guo Y, Yan M, Xiao Y, Dong Y, Zhang R, Qin Y, Bu Y, Zhang Y, Gao H
Molecular and cellular biochemistry 2024 Sep;479(9):2307-2321
Molecular and cellular biochemistry 2024 Sep;479(9):2307-2321
Ubiquitination of p21 by E3 ligase RNF135 promotes the proliferation of human glioblastoma cells.
Gu W, Wang M, Wu Z, Cai Y
Oncology letters 2024 Sep;28(3):406
Oncology letters 2024 Sep;28(3):406
KIAA0753 enhances osteoblast differentiation suppressed by diabetes.
Li M, Wang Y, Wu X, Chen Q, Huang J, Zhu H, Yang S, Wang J, Li LT, Liu X, Fu K, Song F, Wang C
Journal of cellular and molecular medicine 2024 Sep;28(17):e70035
Journal of cellular and molecular medicine 2024 Sep;28(17):e70035
Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH.
Huang Z, Zhang K, Jiang Y, Wang M, Li M, Guo Y, Gao R, Li N, Wang C, Chen J, Wang J, Liu N, Liu X, Liu S, Wei M, Yang C, Yang G
Acta pharmaceutica Sinica. B 2024 Sep;14(9):4001-4013
Acta pharmaceutica Sinica. B 2024 Sep;14(9):4001-4013
Gentiopicroside ameliorates glucose and lipid metabolism in T2DM via targeting FGFR1.
Xu Z, Huang J, Wen M, Zhang X, Lyu D, Li S, Xiao H, Li M, Shen C, Huang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155780
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155780
CCDC68 Maintains Mitotic Checkpoint Activation by Promoting CDC20 Integration into the MCC.
Li Q, Chen Q, Zheng T, Wang F, Teng J, Zhou H, Chen J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(35):e2406009
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(35):e2406009
Uremic Toxin Receptor AhR Facilitates Renal Senescence and Fibrosis via Suppressing Mitochondrial Biogenesis.
Xie H, Yang N, Lu L, Sun X, Li J, Wang X, Guo H, Zhou L, Liu J, Wu H, Yu C, Zhang W, Lu L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(33):e2402066
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(33):e2402066
Tudor-SN exacerbates pathological vascular remodeling by promoting the polyubiquitination of PTEN via NEDD4-1.
Wu Y, Chen Z, Zheng Z, Li X, Shu J, Mao R, An J, Fan S, Luo R, Guo Y, Xu W, Liang M, Huang K, Wang C
Journal of biomedical science 2024 Sep 5;31(1):88
Journal of biomedical science 2024 Sep 5;31(1):88
RNA binding protein ELAVL1-mediated USP33 stabilizes HIF1A to promote pathological proliferation, migration and angiogenesis of RECs.
Xie J, Jiang J, Wang X, Zuo X, Jia Y
International ophthalmology 2024 Sep 25;44(1):393
International ophthalmology 2024 Sep 25;44(1):393
Nogo-B inhibition facilitates cholesterol metabolism to reduce hypercholesterolemia.
Xue C, Zeng P, Gong K, Li Q, Feng Z, Wang M, Chen S, Yang Y, Li J, Zhang S, Yin Z, Liang Y, Yan T, Yu M, Feng K, Zhao D, Yang X, Zhang X, Ma L, Iwakiri Y, Chen L, Tang X, Chen Y, Chen H, Duan Y
Cell reports 2024 Sep 24;43(9):114691
Cell reports 2024 Sep 24;43(9):114691
gp78-regulated KAP1 phosphorylation induces radioresistance in breast cancer by facilitating PPP1CC/PPP2CA ubiquitination.
Han Y, Xiao M, Zhao S, Wang H, Li R, Xu B
iScience 2024 Sep 20;27(9):110847
iScience 2024 Sep 20;27(9):110847
Deubiquitinase USP10 promotes osteosarcoma autophagy and progression through regulating GSK3β-ULK1 axis.
Feng Z, Ou Y, Deng X, Deng M, Yan X, Chen L, Zhou F, Hao L
Cell & bioscience 2024 Sep 2;14(1):111
Cell & bioscience 2024 Sep 2;14(1):111
ARMCX1 inhibits lung adenocarcinoma progression by recruiting FBXW7 for c-Myc degradation.
Hu Z, Wu Y, Sun X, Tong Y, Qiu H, Zhuo E
Biology direct 2024 Sep 16;19(1):82
Biology direct 2024 Sep 16;19(1):82
Promotion of endoplasmic reticulum retrotranslocation by overexpression of E3 ubiquitin-protein ligase synoviolin 1 reduces endoplasmic reticulum stress and preserves cone photoreceptors in cyclic nucleotide-gated channel deficiency.
Yang F, Ma H, Boye SL, Boye SE, Ding XQ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 15;38(17):e70021
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 15;38(17):e70021
Molecular basis of CX-5461-induced DNA damage response in primary vascular smooth muscle cells.
Liu T, Pan G, Zhang J, Wang J, Guo X, Chen Y, Wang X, Cui X, Liu H, Jiang F
Heliyon 2024 Sep 15;10(17):e37227
Heliyon 2024 Sep 15;10(17):e37227
Translation stalling induced mitochondrial entrapment of ribosomal quality control related proteins offers cancer cell vulnerability.
Ojha R, Tantray I, Banerjee S, Rimal S, Thirunavukkarasu S, Srikrishna S, Chiu W, Mete U, Sharma A, Kakkar N, Lu B
Research square 2024 Sep 13;
Research square 2024 Sep 13;
The Syvn1 inhibits neuronal cell ferroptosis by activating Stat3/Gpx4 axis in rat with spinal cord injury.
Xiao S, Zhang Y, Wang S, Liu J, Dan F, Yang F, Hong S, Liu N, Zeng Y, Huang K, Xie X, Zhong Y, Liu Z
Cell proliferation 2024 Oct;57(10):e13658
Cell proliferation 2024 Oct;57(10):e13658
The tumor suppressor Parkin exerts anticancer effects through regulating mitochondrial GAPDH activity.
Sun X, Ye G, Li J, Yuan L, Bai G, Xu YJ, Zhang J
Oncogene 2024 Oct;43(44):3215-3226
Oncogene 2024 Oct;43(44):3215-3226
UBE2S promotes glycolysis in hepatocellular carcinoma by enhancing E3 enzyme-independent polyubiquitination of VHL.
Zhang R, Li C, Zhang S, Kong L, Liu Z, Guo Y, Sun Y, Zhang C, Yong Y, Lv J, Lu M, Liu M, Wu D, Zhang T, Yang H, Wei D, Chen Z, Bian H
Clinical and molecular hepatology 2024 Oct;30(4):771-792
Clinical and molecular hepatology 2024 Oct;30(4):771-792
LncRNA MAAMT facilitates macrophage recruitment and proinflammatory activation and exacerbates autoimmune myocarditis through the SRSF1/NF-κB axis.
Gan T, Liu W, Wang Y, Huang D, Hu J, Wang Y, Xiong J, Wang X, Xu Q, Xiong N, Lu S, Wang Z
International journal of biological macromolecules 2024 Oct;278(Pt 1):134193
International journal of biological macromolecules 2024 Oct;278(Pt 1):134193
Genetic and pharmacological targeting of XBP1 alleviates hepatic ischemia reperfusion injury by enhancing FoxO1-dependent mitophagy.
Kuang B, Wang M, Yan H, Jiang Q, Wang Z, Ni H, Hou S, Peng X, Gu S, Zhao Y, Ou T, Gong N
Translational research : the journal of laboratory and clinical medicine 2024 Oct;272:162-176
Translational research : the journal of laboratory and clinical medicine 2024 Oct;272:162-176
The suppression of OTUD7B by miR-491-5p enhances the ubiquitination of VEGFA to suppress vascular mimicry in non-small cell lung cancer.
Chen X, He L, Zhong H, Yan C, Ke B, Shi L
The journal of gene medicine 2024 Oct;26(10):e3743
The journal of gene medicine 2024 Oct;26(10):e3743
UBE2C orchestrates bone formation through stabilization of SMAD1/5.
Zhang H, Du Y, Lu D, Wang X, Li Y, Qing J, Zhang Y, Liu H, Lv L, Zhang X, Liu Y, Zhou Y, Zhang P
Bone 2024 Oct;187:117175
Bone 2024 Oct;187:117175
Targeting SMYD2 promotes ferroptosis and impacts the progression of pancreatic cancer through the c-Myc/NCOA4 axis-mediated ferritinophagy.
Tan J, Liao S, Yuan B, Liu X, Yu W, Zhan H, Jiang Y, Liu Y
Biochimica et biophysica acta. General subjects 2024 Oct;1868(10):130683
Biochimica et biophysica acta. General subjects 2024 Oct;1868(10):130683
Paeoniflorin suppresses ferroptosis after traumatic brain injury by antagonizing P53 acetylation.
Zhi SM, Cui Y, Liu Y, Zhang JT, Li XJ, Sheng B, Chen XX, Yan CL, Li W, Mao JN, Yan HY, Jin W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155940
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155940
Cinnamaldehyde activates AMPK/PGC-1α pathway via targeting GRK2 to ameliorate heart failure.
Xu Z, Li M, Lyu D, Xiao H, Li S, Li Z, Li M, Xiao J, Huang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155894
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155894
CDK4/6 Inhibitors Impede Chemoresistance and Inhibit Tumor Growth of Small Cell Lung Cancer.
Wen Y, Sun X, Zeng L, Liang S, Li D, Chen X, Zeng F, Zhang C, Wang Q, Zhong Q, Deng L, Guo L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(38):e2400666
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(38):e2400666
Hypoxia-induced DTL promotes the proliferation, metastasis, and sorafenib resistance of hepatocellular carcinoma through ubiquitin-mediated degradation of SLTM and subsequent Notch pathway activation.
Chen ZX, Mu MY, Yang G, Qi H, Fu XB, Wang GS, Jiang WW, Huang BJ, Gao F
Cell death & disease 2024 Oct 9;15(10):734
Cell death & disease 2024 Oct 9;15(10):734
Ubiquitin-mediated degradation of SlPsbS regulates low night temperature tolerance in tomatoes.
Lu J, Yu J, Liu P, Gu J, Chen Y, Zhang T, Li J, Wang T, Yang W, Lin R, Wang F, Qi M, Li T, Liu Y
Cell reports 2024 Oct 22;43(10):114757
Cell reports 2024 Oct 22;43(10):114757
Lysosomal Ca(2+) release-facilitated TFEB nuclear translocation alleviates ischemic brain injury by attenuating autophagic/lysosomal dysfunction in neurons.
Lei Q, Chen X, Xiong Y, Li S, Wang J, He H, Deng Y
Scientific reports 2024 Oct 22;14(1):24836
Scientific reports 2024 Oct 22;14(1):24836
Interplay between acetylation and ubiquitination controls PSAT1 protein stability in lung adenocarcinoma.
Liu Y, Xun W, Zhao T, Huang M, Sun L, Wen G, Kang X, Wang J, Han T
Communications biology 2024 Oct 21;7(1):1365
Communications biology 2024 Oct 21;7(1):1365
Superenhancer-driven circRNA Myst4 involves in pulmonary artery smooth muscle cell ferroptosis in pulmonary hypertension.
He S, Bai J, Zhang L, Yuan H, Ma C, Wang X, Guan X, Mei J, Zhu X, Xin W, Zhu D
iScience 2024 Oct 18;27(10):110900
iScience 2024 Oct 18;27(10):110900
Nesfatin-1 enhances vascular smooth muscle calcification through facilitating BMP-2 osteogenic signaling.
Zhu XX, Meng XY, Chen G, Su JB, Fu X, Xu AJ, Liu Y, Hou XH, Qiu HB, Sun QY, Hu JY, Lv ZL, Sun HJ, Jiang HB, Han ZJ, Zhu J, Lu QB
Cell communication and signaling : CCS 2024 Oct 11;22(1):488
Cell communication and signaling : CCS 2024 Oct 11;22(1):488
Tumor-associated macrophages/C-X-C motif chemokine ligand 1 promotes breast cancer autophagy-mediated chemoresistance via IGF1R/STAT3/HMGB1 signaling.
Yang B, Li G, Wang S, Zheng Y, Zhang J, Pan B, Wang N, Wang Z
Cell death & disease 2024 Oct 11;15(10):743
Cell death & disease 2024 Oct 11;15(10):743
O-GlcNAcylation regulation of RIPK1-dependent apoptosis dictates sensitivity to sunitinib in renal cell carcinoma.
Zeng X, Chen Z, Zhu Y, Liu L, Zhang Z, Xiao Y, Wang Q, Pang S, Zhao F, Xu B, Leng M, Liu X, Hu C, Zeng S, Li F, Xie W, Tan W, Zheng Z
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Nov;77:101150
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Nov;77:101150
MDM2 accelerated renal senescence via ubiquitination and degradation of HDAC1.
Xiang HL, Yuan Q, Zeng JY, Xu ZY, Zhang HZ, Huang J, Song AN, Xiong J, Zhang C
Acta pharmacologica Sinica 2024 Nov;45(11):2328-2338
Acta pharmacologica Sinica 2024 Nov;45(11):2328-2338
O-GlcNAcylation of circadian clock protein Bmal1 impairs cognitive function in diabetic mice.
Hui Y, Zhong Y, Kuang L, Xu J, Hao Y, Cao J, Zheng T
The EMBO journal 2024 Nov;43(22):5667-5689
The EMBO journal 2024 Nov;43(22):5667-5689
Rack1 regulates B-cell development and function by binding to and stabilizing the transcription factor Pax5.
Zhang X, Ma C, Lu Y, Wang J, Yun H, Jiang H, Wu M, Feng X, Gai W, Xu G, Deng H, Feng J, Liu W, Shi T, Cheng Q, Zhang J
Cellular & molecular immunology 2024 Nov;21(11):1282-1295
Cellular & molecular immunology 2024 Nov;21(11):1282-1295
CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity.
Ye Y, Jia P, Miao J, Wang Y, Li Z, Lin Y, He M, Liu S, Zheng BR, Wu J, Pan J, Li CM, Hou P, Guo D
Autophagy 2024 Nov;20(11):2529-2539
Autophagy 2024 Nov;20(11):2529-2539
Activation of BK channels prevents diabetes-induced osteopenia by regulating mitochondrial Ca(2+) and SLC25A5/ANT2-PINK1-PRKN-mediated mitophagy.
Jiang L, He H, Tang Y, Li J, Reilly S, Xin H, Li Z, Cai H, Zhang X
Autophagy 2024 Nov;20(11):2388-2404
Autophagy 2024 Nov;20(11):2388-2404
Targeting USP11 regulation by a novel lithium-organic coordination compound improves neuropathologies and cognitive functions in Alzheimer transgenic mice.
Guo Y, Cai C, Zhang B, Tan B, Tang Q, Lei Z, Qi X, Chen J, Zheng X, Zi D, Li S, Tan J
EMBO molecular medicine 2024 Nov;16(11):2856-2881
EMBO molecular medicine 2024 Nov;16(11):2856-2881
Luteolin detoxifies DEHP and prevents liver injury by degrading Uroc1 protein in mice.
Wang H, Zhao Z, Song M, Zhang W, Liu C, Chen S
EMBO molecular medicine 2024 Nov;16(11):2699-2724
EMBO molecular medicine 2024 Nov;16(11):2699-2724
CaMKII Exacerbates Doxorubicin-Induced Cardiotoxicity by Promoting Ubiquitination Through USP10 Inhibition.
Yang Y, Wang Z, Wang N, Yang J, Yang L
Cancer medicine 2024 Nov;13(21):e70286
Cancer medicine 2024 Nov;13(21):e70286
Mitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 Deubiquitination.
Yin Y, Li Y, Ma B, Ren C, Zhao S, Li J, Gong Y, Yang H, Li J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(43):e2405620
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(43):e2405620
Psmb8 inhibits mitochondrial fission and alleviates myocardial ischaemia/reperfusion injury by targeting Drp1 degradation.
Su HX, Xu LL, Li PB, Bi HL, Jiang WX, Li HH
Cell death & disease 2024 Nov 8;15(11):803
Cell death & disease 2024 Nov 8;15(11):803
ΔNp63α promotes radioresistance in esophageal squamous cell carcinoma through the PLEC-KEAP1-NRF2 feedback loop.
Tao J, Mao M, Lu Y, Deng L, Yu S, Zeng X, Jia W, Wu Z, Li C, Ma R, Chen H
Cell death & disease 2024 Nov 5;15(11):793
Cell death & disease 2024 Nov 5;15(11):793
Lactylation stabilizes TFEB to elevate autophagy and lysosomal activity.
Huang Y, Luo G, Peng K, Song Y, Wang Y, Zhang H, Li J, Qiu X, Pu M, Liu X, Peng C, Neculai D, Sun Q, Zhou T, Huang P, Liu W
The Journal of cell biology 2024 Nov 4;223(11)
The Journal of cell biology 2024 Nov 4;223(11)
14-3-3 proteins inhibit autophagy by regulating SINAT-mediated proteolysis of ATG6 in Arabidopsis.
Liu T, Zheng Y, Zhou S, Wang Y, Lei X, Xie L, Lin Q, Chang C, Xiao S, Qiu R, Qi H
BMC plant biology 2024 Nov 29;24(1):1148
BMC plant biology 2024 Nov 29;24(1):1148
CLIP170 enhancing FOSL1 expression via attenuating ubiquitin-mediated degradation of β-catenin drives renal cell carcinoma progression.
Huang Y, Wen Z, Tao S, Yu Z, Wang X, Li X, Gao L
Cellular and molecular life sciences : CMLS 2024 Nov 28;81(1):467
Cellular and molecular life sciences : CMLS 2024 Nov 28;81(1):467
Mitophagy-Enhanced Nanoparticle-Engineered Mitochondria Restore Homeostasis of Mitochondrial Pool for Alleviating Pulmonary Fibrosis.
Wang Y, Hu LF, Liu NH, Yang JS, Xing L, Jeong JH, Li L, Jiang HL
ACS nano 2024 Nov 26;18(47):32705-32722
ACS nano 2024 Nov 26;18(47):32705-32722
Arginine methylation-dependent TRIM47 stability mediated by CARM1 promotes the metastasis of hepatocellular carcinoma.
Tang Y, Meng X, Luo X, Yao W, Tian L, Zhang Z, Zhao Y, Xiao J, Zhu H, Hu J
Cell death discovery 2024 Nov 20;10(1):477
Cell death discovery 2024 Nov 20;10(1):477
Tripartite motif 25 inhibits protein aggregate degradation during PRRSV infection by suppressing p62-mediated autophagy.
Ren J, Pei Q, Dong H, Wei X, Li L, Duan H, Zhang G, Zhang A
Journal of virology 2024 Nov 19;98(11):e0143724
Journal of virology 2024 Nov 19;98(11):e0143724
SPIN1 accelerates tumorigenesis and confers radioresistance in non-small cell lung cancer by orchestrating the FOXO3a/FOXM1 axis.
Zhong M, Fang Z, Zou J, Chen X, Qiu Z, Zhou L, Le Y, Chen Z, Liao Y, Nie F, Wei X, Zhan J, Xiong J, Xiang X, Fang Z
Cell death & disease 2024 Nov 15;15(11):832
Cell death & disease 2024 Nov 15;15(11):832
MDM4 inhibits ferroptosis in p53 mutant colon cancer via regulating TRIM21/GPX4 expression.
Liu J, Wei X, Xie Y, Yan Y, Xue S, Wang X, Chen H, Pan Q, Yan S, Zheng X, Huang Q
Cell death & disease 2024 Nov 14;15(11):825
Cell death & disease 2024 Nov 14;15(11):825
Gaudichaudione H ameliorates liver fibrosis and inflammation by targeting NRF2 signaling pathway.
Shi M, Guo Y, Xu J, Yan L, Li X, Liu R, Feng Y, Zhang Y, Zhao Y, Zhang C, Du K, Li M, Zhang Y, Zhang J, Li Z, Ren D, Liu P
Free radical biology & medicine 2024 Nov 1;224:770-784
Free radical biology & medicine 2024 Nov 1;224:770-784
Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes.
Huang W, Wu D, Cai C, Yao H, Tian Z, Yang Y, Pang M, Rong L, Liu B
Redox biology 2024 May;71:103104
Redox biology 2024 May;71:103104
N6-Methyladenosine Modification of lncCCKAR-5 Regulates Autophagy in Human Umbilical Cord Mesenchymal Stem Cells by Destabilizing LMNA and Inhibits Diabetic Wound Healing.
Wang J, Wang X, Chen F, Ning Q, Liu Y, Zhu Y, Wei W, Leng M, Wang Z, Jin P, Li Q
The Journal of investigative dermatology 2024 May;144(5):1148-1160.e15
The Journal of investigative dermatology 2024 May;144(5):1148-1160.e15
Phosphorylated SHMT2 Regulates Oncogenesis Through m(6)A Modification in Lung Adenocarcinoma.
Han T, Wang Y, Cheng M, Hu Q, Wan X, Huang M, Liu Y, Xun W, Xu J, Wang L, Luo R, Yuan Y, Wang K, Wang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(18):e2307834
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(18):e2307834
MiR-31-5p alleviates septic cardiomyopathy by targeting BAP1 to inhibit SLC7A11 deubiquitination and ferroptosis.
Liu Y, Hu N, Ai B, Xia H, Li W
BMC cardiovascular disorders 2024 May 30;24(1):286
BMC cardiovascular disorders 2024 May 30;24(1):286
LncRNA RGMB-AS1 inhibits HMOX1 ubiquitination and NAA10 activation to induce ferroptosis in non-small cell lung cancer.
Gao GB, Chen L, Pan JF, Lei T, Cai X, Hao Z, Wang Q, Shan G, Li J
Cancer letters 2024 May 28;590:216826
Cancer letters 2024 May 28;590:216826
Contrasting Impacts of Ubiquitin Overexpression on Arabidopsis Growth and Development.
Yu P, Gao Z, Hua Z
Plants (Basel, Switzerland) 2024 May 28;13(11)
Plants (Basel, Switzerland) 2024 May 28;13(11)
ECHDC2 inhibits the proliferation of gastric cancer cells by binding with NEDD4 to degrade MCCC2 and reduce aerobic glycolysis.
He J, Yi J, Ji L, Dai L, Chen Y, Xue W
Molecular medicine (Cambridge, Mass.) 2024 May 23;30(1):69
Molecular medicine (Cambridge, Mass.) 2024 May 23;30(1):69
Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop.
Yang S, Xie J, Pan Z, Guan H, Tu Y, Ye Y, Huang S, Fu S, Li K, Huang Z, Li X, Shi Z, Li L, Zhang Y
Experimental & molecular medicine 2024 Mar;56(3):630-645
Experimental & molecular medicine 2024 Mar;56(3):630-645
RNF125‑mediated ubiquitination of MCM6 regulates the proliferation of human liver hepatocellular carcinoma cells.
Feng X, Song D, Liu X, Liang Y, Jiang P, Wu S, Liu F
Oncology letters 2024 Mar;27(3):105
Oncology letters 2024 Mar;27(3):105
Integrin β8 prevents pericyte-myofibroblast transition and renal fibrosis through inhibiting the TGF-β1/TGFBR1/Smad3 pathway in diabetic kidney disease.
Cao Y, Su H, Zeng J, Xie Y, Liu Z, Liu F, Qiu Y, Yi F, Lin J, Hammes HP, Zhang C
Translational research : the journal of laboratory and clinical medicine 2024 Mar;265:36-50
Translational research : the journal of laboratory and clinical medicine 2024 Mar;265:36-50
β-Sitosterol targets ASS1 for Nrf2 ubiquitin-dependent degradation, inducing ROS-mediated apoptosis via the PTEN/PI3K/AKT signaling pathway in ovarian cancer.
Wang H, Liu J, Zhang Z, Peng J, Wang Z, Yang L, Wang X, Hu S, Hong L
Free radical biology & medicine 2024 Mar;214:137-157
Free radical biology & medicine 2024 Mar;214:137-157
USP46 enhances tamoxifen resistance in breast cancer cells by stabilizing PTBP1 to facilitate glycolysis.
Gao S, Wang Y, Xu Y, Liu L, Liu S
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167011
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167011
Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy.
Linghu KG, Zhang T, Zhang GT, Lv P, Zhang WJ, Zhao GD, Xiong SH, Ma QS, Zhao MM, Chen M, Hu YJ, Zhang CS, Yu H
Journal of pharmaceutical analysis 2024 Mar;14(3):401-415
Journal of pharmaceutical analysis 2024 Mar;14(3):401-415
BRCC36 Deubiquitinates HMGCR to Regulate the Interplay Between Ferroptosis and Pyroptosis.
Wang H, Shu L, Lv C, Liu N, Long Y, Peng X, Ling H, Tao T, Tang J, Cheng Y, Liu S, Xiao D, Tao Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(11):e2304263
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(11):e2304263
A regulatory module comprising G3BP1-FBXL5-IRP2 axis determines sodium arsenite-induced ferroptosis.
Liu Q, Wang F, Chen Y, Cui H, Wu H
Journal of hazardous materials 2024 Mar 5;465:133038
Journal of hazardous materials 2024 Mar 5;465:133038
Cardiac injury activates STING signaling via upregulating SIRT6 in macrophages after myocardial infarction.
Kong W, Chen J, Ruan X, Xu X, Li X, Bao M, Shao Y, Bian X, Li R, Jiang Q, Zhang Y, Li Z, Yan F, Ye J
Life sciences 2024 Mar 15;341:122474
Life sciences 2024 Mar 15;341:122474
NSP6 inhibits the production of ACE2-containing exosomes to promote SARS-CoV-2 infectivity.
Lv X, Chen R, Liang T, Peng H, Fang Q, Xiao S, Liu S, Hu M, Yu F, Cao L, Zhang Y, Pan T, Xi Z, Ding Y, Feng L, Zeng T, Huang W, Zhang H, Ma X
mBio 2024 Mar 13;15(3):e0335823
mBio 2024 Mar 13;15(3):e0335823
UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5.
Li J, Liang Y, Zhou S, Chen J, Wu C
Breast cancer research : BCR 2024 Mar 11;26(1):44
Breast cancer research : BCR 2024 Mar 11;26(1):44
Ubiquitin-specific protease 54 regulates GLUT1-mediated aerobic glycolysis to inhibit lung adenocarcinoma progression by modifying p53 degradation.
Chen L, Zhang L, He H, Shao F, Yu Z, Gao Y, He J
Oncogene 2024 Jun;43(26):2025-2037
Oncogene 2024 Jun;43(26):2025-2037
MGMT activated by Wnt pathway promotes cisplatin tolerance through inducing slow-cycling cells and nonhomologous end joining in colorectal cancer.
Zhang H, Li Q, Guo X, Wu H, Hu C, Liu G, Yu T, Hu X, Qiu Q, Guo G, She J, Chen Y
Journal of pharmaceutical analysis 2024 Jun;14(6):100950
Journal of pharmaceutical analysis 2024 Jun;14(6):100950
Chaperones Hsc70 and Hsp70 play distinct roles in the replication of bocaparvovirus minute virus of canines.
Guo J, Yan Y, Sun J, Ji K, Hei Z, Zeng L, Xu H, Ren X, Sun Y
Molecular microbiology 2024 Jun;121(6):1127-1147
Molecular microbiology 2024 Jun;121(6):1127-1147
E3 ubiquitin ligase CHIP interacts with transferrin receptor 1 for degradation and promotes cell proliferation through inhibiting ferroptosis in hepatocellular carcinoma.
Shao M, Qi K, Wang L, Yu X, Zhang Q, Yu L, Wang L, Yang C, Fan L
Cellular signalling 2024 Jun;118:111148
Cellular signalling 2024 Jun;118:111148
OLFM4 promotes the progression of intestinal metaplasia through activation of the MYH9/GSK3β/β-catenin pathway.
Wei H, Li W, Zeng L, Ding N, Li K, Yu H, Jiang F, Yin H, Xia Y, Deng C, Cai N, Chen X, Gu L, Chen H, Zhang F, He Y, Li J, Zhang C
Molecular cancer 2024 Jun 7;23(1):124
Molecular cancer 2024 Jun 7;23(1):124
P53 upregulation by USP7-engaging molecular glues.
Li Z, Wang Z, Zhong C, Zhang H, Liu R, An P, Ma Z, Lu J, Pan C, Zhang Z, Cao Z, Hu J, Xing D, Fei Y, Ding Y, Lu B
Science bulletin 2024 Jun 30;69(12):1936-1953
Science bulletin 2024 Jun 30;69(12):1936-1953
Novel TUBA4A variant causes congenital myopathy with focal myofibrillar disorganisation.
Wan Y, Zhou C, Chang X, Wu L, Zheng Y, Yu J, Bai L, Luan M, Yu M, Wang Q, Zhang W, Yuan Y, Deng J, Wang Z
Journal of medical genetics 2024 Jun 20;61(7):626-632
Journal of medical genetics 2024 Jun 20;61(7):626-632
RUNX1 regulates MCM2/CDC20 to promote COAD progression modified by deubiquitination of USP31.
Tian W, Zhao J, Zhang X, Li P, Li X, Hong Y, Li S
Scientific reports 2024 Jun 17;14(1):13906
Scientific reports 2024 Jun 17;14(1):13906
The COP9 signalosome stabilized MALT1 promotes Non-Small Cell Lung Cancer progression through activation of NF-κB pathway.
Wang Y, Deng X, Xie J, Lu T, Qian R, Guo Z, Zeng X, Liao J, Ding Z, Zhou M, Niu X
Cell biology and toxicology 2024 Jun 12;40(1):45
Cell biology and toxicology 2024 Jun 12;40(1):45
Smooth muscle NF90 deficiency ameliorates diabetic atherosclerotic calcification in male mice via FBXW7-AGER1-AGEs axis.
Xie F, Liu B, Qiao W, He JZ, Cheng J, Wang ZY, Hou YM, Zhang X, Xu BH, Zhang Y, Chen YG, Zhang MX
Nature communications 2024 Jun 11;15(1):4985
Nature communications 2024 Jun 11;15(1):4985
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway.
Su Q, Wang JJ, Ren JY, Wu Q, Chen K, Tu KH, Zhang Y, Leong SW, Sarwar A, Han X, Zhang M, Dai WF, Zhang YM
Acta pharmacologica Sinica 2024 Jul;45(7):1520-1529
Acta pharmacologica Sinica 2024 Jul;45(7):1520-1529
CBLC promotes the development of colorectal cancer by promoting ABI1 degradation to activate the ERK signaling pathway.
Li Z, Yan G, Yang M, Liu X, Lian Y, Sun M, Pan W
Translational oncology 2024 Jul;45:101992
Translational oncology 2024 Jul;45:101992
Neuronal activity promotes secretory autophagy for the extracellular release of α-synuclein.
Nakamura Y, Sawai T, Kakiuchi K, Arawaka S
The Journal of biological chemistry 2024 Jul;300(7):107419
The Journal of biological chemistry 2024 Jul;300(7):107419
USP7 promotes cardiometabolic disorders and mitochondrial homeostasis dysfunction in diabetic mice via stabilizing PGC1β.
Yan M, Su L, Wu K, Mei Y, Liu Z, Chen Y, Zeng W, Xiao Y, Zhang J, Cai G, Bai Y
Pharmacological research 2024 Jul;205:107235
Pharmacological research 2024 Jul;205:107235
RACK1 enhances STAT3 stability and promotes T follicular helper cell development and function during blood-stage Plasmodium infection in mice.
Cheng Q, Yang X, Zou T, Sun L, Zhang X, Deng L, Wu M, Gai W, Jiang H, Guo T, Lu Y, Dong J, Niu C, Pan W, Zhang J
PLoS pathogens 2024 Jul;20(7):e1012352
PLoS pathogens 2024 Jul;20(7):e1012352
USP9X regulates the proliferation, survival, migration and invasion of gastric cancer cells by stabilizing MTH1.
Xu W, Zhang Y, Su Y, Li L, Yang X, Wang L, Gao H
BMC gastroenterology 2024 Jul 29;24(1):239
BMC gastroenterology 2024 Jul 29;24(1):239
CHIP-mediated ubiquitin degradation of BCAT1 regulates glioma cell proliferation and temozolomide sensitivity.
Lu Z, Wang XY, He KY, Han XH, Wang X, Zhang Z, Qu XH, Chen ZP, Han XJ, Wang T
Cell death & disease 2024 Jul 29;15(7):538
Cell death & disease 2024 Jul 29;15(7):538
Identification of mechanism of the oncogenic role of FGFR1 in papillary thyroid carcinoma.
Li XB, Li JL, Wang C, Zhang Y, Li J
European journal of histochemistry : EJH 2024 Jul 22;68(3)
European journal of histochemistry : EJH 2024 Jul 22;68(3)
Dual-Responsive Epigenetic Inhibitor Nanoprodrug Combined with Oncolytic Virus Synergistically Boost Cancer Immunotherapy by Igniting Gasdermin E-Mediated Pyroptosis.
Wang YY, Wang J, Wang S, Yang QC, Song A, Zhang MJ, Wang WD, Liu YT, Zhang J, Wang WM, Xu Z, Sun ZJ
ACS nano 2024 Jul 22;
ACS nano 2024 Jul 22;
CircSMAD3 represses SMAD3 phosphorylation and ameliorates cardiac remodeling by recruiting YBX1.
Mei S, Ma X, Zhou L, Wuyun Q, Wang J, Xiao Q, Wang M, Zhang K, Chen C, Yan J, Ding H
iScience 2024 Jul 19;27(7):110200
iScience 2024 Jul 19;27(7):110200
WWP1 inhibition increases SHP2 inhibitor efficacy in colorectal cancer.
Fan H, Hu X, Cao F, Zhou L, Wen R, Shen H, Fu Y, Zhu X, Jia H, Liu Z, Wang G, Yu G, Chang W, Zhang W
NPJ precision oncology 2024 Jul 16;8(1):144
NPJ precision oncology 2024 Jul 16;8(1):144
An engineered DNA aptamer-based PROTAC for precise therapy of p53-R175H hotspot mutant-driven cancer.
Kong L, Meng F, Zhou P, Ge R, Geng X, Yang Z, Li G, Zhang L, Wang J, Ma J, Dong C, Zhou J, Wu S, Zhong D, Xie S
Science bulletin 2024 Jul 15;69(13):2122-2135
Science bulletin 2024 Jul 15;69(13):2122-2135
NEDD4L Promotes IκBα Ubiquitination and Degradation in the Pathogenesis of Diabetic Retinopathy.
Cui L, Ma J
Current eye research 2024 Jan;49(1):62-72
Current eye research 2024 Jan;49(1):62-72
New mode of action of curcumin on prostate cancer cells: Modulation of endoplasmic reticulum-associated degradation mechanism and estrogenic signaling.
Erzurumlu Y, Dogan HK, Catakli D
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23636
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23636
Pseudorabies virus inhibits progesterone-induced inactivation of TRPML1 to facilitate viral entry.
Su BQ, Yang GY, Wang J, Ming SL, Chu BB
PLoS pathogens 2024 Jan;20(1):e1011956
PLoS pathogens 2024 Jan;20(1):e1011956
IL-22-Induced Ubiquitin-Specific Protease 15 Promotes Proliferation and Inflammation of Keratinocytes through Stabilization of Squamous Cell Carcinoma Antigen 2.
Chen F, Wu S, Zhan J, Jin Y, Xuan X, Cao J, Wu T, Liang Y, Zhao X, Li Z, Wang Y, Chen L, Li Y, El Ghalbzouri A, Huang C
The Journal of investigative dermatology 2024 Jan;144(1):63-72.e4
The Journal of investigative dermatology 2024 Jan;144(1):63-72.e4
Taxifolin inhibits melanoma proliferation/migration impeding USP18/Rac1/JNK/β-catenin oncogenic signaling.
Xu L, Zhang L, Zhang S, Yang J, Zhu A, Sun J, Kalvakolanu DV, Cong X, Zhang J, Tang J, Guo B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155199
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155199
Stability and function of RCL1 are dependent on the interaction with BMS1.
Wang Y, Zhao Z, Yu H, Shi H, Tao B, He Y, Chen J, Peng J, Gan M, Lo LJ
Journal of molecular cell biology 2024 Jan 5;15(7)
Journal of molecular cell biology 2024 Jan 5;15(7)
Nicotinamide mononucleotide attenuates airway epithelial barrier dysfunction via inhibiting SIRT3 SUMOylation in asthma.
Liang J, Zhou C, Zhang C, Liang S, Zhou Z, Zhou Z, Wu C, Zhao H, Meng X, Zou F, Yu C, Cai S
International immunopharmacology 2024 Jan 25;127:111328
International immunopharmacology 2024 Jan 25;127:111328
The feedback loop of EFTUD2/c-MYC impedes chemotherapeutic efficacy by enhancing EFTUD2 transcription and stabilizing c-MYC protein in colorectal cancer.
Zhu X, Li C, Gao Y, Zhang Q, Wang T, Zhou H, Bu F, Chen J, Mao X, He Y, Wu K, Li N, Luo H
Journal of experimental & clinical cancer research : CR 2024 Jan 2;43(1):7
Journal of experimental & clinical cancer research : CR 2024 Jan 2;43(1):7
TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.
Hao XL, Lv YF, Li DF, Bai FH, Gong J, Pan GQ, Su LX, Wang YL, Fu WL, Liu B, Huang L, Yan D, Tan QL, Liu JY, Guo QN
Journal of translational medicine 2024 Jan 2;22(1):6
Journal of translational medicine 2024 Jan 2;22(1):6
Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells.
Zhu Q, Liang P, Meng H, Li F, Miao W, Chu C, Wang W, Li D, Chen C, Shi Y, Yu X, Ping Y, Niu C, Wu HB, Zhang A, Bian XW, Zhou W
Nature communications 2024 Jan 2;15(1):40
Nature communications 2024 Jan 2;15(1):40
LINC00571 drives tricarboxylic acid cycle metabolism in triple-negative breast cancer through HNRNPK/ILF2/IDH2 axis.
Xi Z, Huang H, Hu J, Yu Y, Ma X, Xu M, Ming J, Li L, Zhang H, Chen H, Huang T
Journal of experimental & clinical cancer research : CR 2024 Jan 18;43(1):22
Journal of experimental & clinical cancer research : CR 2024 Jan 18;43(1):22
N-arachidonoylphenolamine alleviates ischaemia/reperfusion-induced cardiomyocyte necroptosis by restoring proteasomal activity.
Bai JQ, Li PB, Li CM, Li HH
European journal of pharmacology 2024 Jan 15;963:176235
European journal of pharmacology 2024 Jan 15;963:176235
Natural Product Baohuoside I Impairs the Stability and Membrane Location of MRP2 Reciprocally Regulated by SUMOylation and Ubiquitination in Hepatocytes.
Zhao Z, Du JF, Wang QL, Qiu FN, Li P, Jiang Y, Li HJ
Chemical research in toxicology 2024 Jan 15;37(1):57-71
Chemical research in toxicology 2024 Jan 15;37(1):57-71
PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer.
Xu L, Xiang W, Yang J, Gao J, Wang X, Meng L, Ye K, Zhao XH, Zhang XD, Jin L, Ye Y
Journal of experimental & clinical cancer research : CR 2024 Jan 11;43(1):17
Journal of experimental & clinical cancer research : CR 2024 Jan 11;43(1):17
miR-26a exerts broad-spectrum antiviral effects via the enhancement of RIG-I-mediated type I interferon response by targeting USP15.
Zhang J, Li C, Hou Y, Liu D, Li Q, Wang Z, Tang R, Zheng K, Guo H, Wang W
Microbiology spectrum 2024 Jan 11;12(1):e0312423
Microbiology spectrum 2024 Jan 11;12(1):e0312423
Acylated Ghrelin Activates PI3K/mTOR Signaling Pathway by Promoting ThPOK Acetylation to Promote Milk Fat Synthesis in Bovine Mammary Epithelial Cells.
Wang J, Cao Y, Long X, Li F, Jiang N, Sun M, Xie Y, Ge Y, Guo W, Liu J, Fu S
Journal of agricultural and food chemistry 2024 Jan 10;72(1):390-404
Journal of agricultural and food chemistry 2024 Jan 10;72(1):390-404
Shank3 ameliorates neuronal injury after cerebral ischemia/reperfusion via inhibiting oxidative stress and inflammation.
Zhang H, Feng Y, Si Y, Lu C, Wang J, Wang S, Li L, Xie W, Yue Z, Yong J, Dai S, Zhang L, Li X
Redox biology 2024 Feb;69:102983
Redox biology 2024 Feb;69:102983
Degradation of AZGP1 suppresses the progression of breast cancer cells via TRIM25.
Qin H, Yuan Y, Yuan M, Wang H, Yang Y
Environmental toxicology 2024 Feb;39(2):882-889
Environmental toxicology 2024 Feb;39(2):882-889
ABLIM1, a novel ubiquitin E3 ligase, promotes growth and metastasis of colorectal cancer through targeting IĸBα ubiquitination and activating NF-ĸB signaling.
He Y, Shi Q, Ling Y, Guo H, Fei Y, Wu R, Tang C, Zhang X, Yao L
Cell death and differentiation 2024 Feb;31(2):203-216
Cell death and differentiation 2024 Feb;31(2):203-216
Upregulation of TRIM16 mitigates doxorubicin-induced cardiotoxicity by modulating TAK1 and YAP/Nrf2 pathways in mice.
Guo X, Liu M, Han B, Zheng Y, Zhang K, Bao G, Gao C, Shi H, Sun Q, Zhao Z
Biochemical pharmacology 2024 Feb;220:116009
Biochemical pharmacology 2024 Feb;220:116009
WWP2 protects against sepsis-induced cardiac injury through inhibiting cardiomyocyte ferroptosis.
Li Z, Wu B, Chen J, Ye N, Ma R, Song C, Sun Y, Zhang X, Sun G
Journal of translational internal medicine 2024 Feb;12(1):35-50
Journal of translational internal medicine 2024 Feb;12(1):35-50
Regulator of Ribosome Synthesis 1 (RRS1) Stabilizes GRP78 and Promotes Breast Cancer Progression.
Sun W, Song J, Wu Q, Deng L, Zhang T, Zhang L, Hua Y, Cao Y, Hou L
Molecules (Basel, Switzerland) 2024 Feb 28;29(5)
Molecules (Basel, Switzerland) 2024 Feb 28;29(5)
The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3.
Wang Y, Li X, Guan X, Song Z, Liu H, Guan Z, Wang J, Zhu L, Zhang D, Zhao L, Xie P, Wei X, Shang N, Liu Y, Jin Z, Ji Z, Dai G
International journal of molecular sciences 2024 Feb 27;25(5)
International journal of molecular sciences 2024 Feb 27;25(5)
KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC.
Li J, Shi D, Li S, Shi X, Liu Y, Zhang Y, Wang G, Zhang C, Xia T, Piao HL, Liu HX
Cell death & disease 2024 Feb 27;15(2):175
Cell death & disease 2024 Feb 27;15(2):175
WSB1, as an E3 ligase, restrains myocardial ischemia-reperfusion injury by activating β-catenin signaling via promoting GSK3β ubiquitination.
Fang L, Tao Y, Che G, Yun Y, Ren M, Liu Y
Molecular medicine (Cambridge, Mass.) 2024 Feb 23;30(1):31
Molecular medicine (Cambridge, Mass.) 2024 Feb 23;30(1):31
The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer.
Khalil MI, Yang C, Vu L, Chadha S, Nabors H, James CD, Morgan IM, Pyeon D
Journal of virology 2024 Feb 20;98(2):e0172623
Journal of virology 2024 Feb 20;98(2):e0172623
Inhibition of RIPK1 alleviating vascular smooth muscle cells osteogenic transdifferentiation via Runx2.
Li Y, Jie W, Qi Y, Mo M, Lian Y, Yin L, Huang H
iScience 2024 Feb 16;27(2):108766
iScience 2024 Feb 16;27(2):108766
HECW1 restrains cervical cancer cell growth by promoting DVL1 ubiquitination and downregulating the activation of Wnt/β-catenin signaling.
Xu Z, Guo Y, Wang L, Cui J
Experimental cell research 2024 Feb 15;435(2):113949
Experimental cell research 2024 Feb 15;435(2):113949
Hypothermic oxygenated perfusion inhibits CLIP1-mediated TIRAP ubiquitination via TFPI2 to reduce ischemia‒reperfusion injury of the fatty liver.
Yue P, Lv X, Cao H, Zou Y, You J, Luo J, Lu Z, Chen H, Liu Z, Zhong Z, Xiong Y, Fan X, Ye Q
Experimental & molecular medicine 2024 Dec;56(12):2588-2601
Experimental & molecular medicine 2024 Dec;56(12):2588-2601
USP28 promotes tumor progression and glycolysis by stabilizing PKM2/Hif1-α in cholangiocarcinoma.
Qiao Q, Wang J, Liu S, Chang J, Zhou T, Li C, Zhang Y, Jiang W, Chen Y, Xu X, Wu M, Li X
Cellular oncology (Dordrecht, Netherlands) 2024 Dec;47(6):2217-2231
Cellular oncology (Dordrecht, Netherlands) 2024 Dec;47(6):2217-2231
ITFG2 as a NEDD4-2 inhibitor: Preserving calcium homeostasis to prevent myocardial ischemic injury.
Liu F, Lv LF, Bi FF, Pan QM, Jing ZH, Cui C, Cao M, Yu T, Li J, He YJ, Xiao HW, Tian H, Wu Y, Shan HL, Zhou YH
Biochemical pharmacology 2024 Dec;230(Pt 2):116597
Biochemical pharmacology 2024 Dec;230(Pt 2):116597
Discovery of novel 20S proteasome subunit β5 PROTAC degraders as potential therapeutics for pharyngeal carcinoma and Bortezomib-resistant multiple myeloma.
Wang S, Li Z, Ma S, Zhang S, Guo S, Ma Z, Du L, Li M
Bioorganic chemistry 2024 Dec;153:107801
Bioorganic chemistry 2024 Dec;153:107801
Cepharanthine sensitizes gastric cancer cells to chemotherapy by targeting TRIB3-FOXO3-FOXM1 axis to inhibit autophagy.
Lu YY, Fang YY, Wang SS, Guo J, Song JL, Zhu L, Lin ZK, Wang R, Zhang SY, Qiu WS, Qi WW
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156161
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156161
Aloe Emodin Alleviates Radiation-Induced Heart Disease via Blocking P4HB Lactylation and Mitigating Kynurenine Metabolic Disruption.
Ouyang F, Li Y, Wang H, Liu X, Tan X, Xie G, Zeng J, Zeng G, Luo Q, Zhou H, Chen S, Hou K, Fang J, Zhang X, Zhou L, Li Y, Gao A
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(47):e2406026
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(47):e2406026
CDK9 recruits HUWE1 to degrade RARα and offers therapeutic opportunities for cutaneous T-cell lymphoma.
Luo CH, Hu LH, Liu JY, Xia L, Zhou L, Sun RH, Lin CC, Qiu X, Jiang B, Yang MY, Zhang XH, Yang XB, Chen GQ, Lu Y
Nature communications 2024 Dec 5;15(1):10594
Nature communications 2024 Dec 5;15(1):10594
The role of the PI3K/AKT/mTOR pathway in mediating PD-L1 upregulation during fibroblast transdifferentiation.
Zhao Y, Qi Y, Xia J, Duan M, Hao C, Yao W
International immunopharmacology 2024 Dec 5;142(Pt B):113186
International immunopharmacology 2024 Dec 5;142(Pt B):113186
The facilitating effects of KRT80 on chemoresistance, lipogenesis, and invasion of esophageal cancer.
Yun WJ, Li J, Yin NC, Zhang CY, Cui ZG, Zhang L, Zheng HC
Cancer biology & therapy 2024 Dec 31;25(1):2302162
Cancer biology & therapy 2024 Dec 31;25(1):2302162
PTGES3 proteolysis using the liposomal peptide-PROTAC approach.
Liu S, Yuan F, Dong H, Zhang J, Mao X, Liu Y, Li H
Biology direct 2024 Dec 26;19(1):144
Biology direct 2024 Dec 26;19(1):144
Pyroptosis mediated by Parkin-NLRP3 negative feedback loop contributed to Parkinson's disease induced by rotenone.
Zheng D, Lai Y, Huang K, Guan D, Xie Z, Fu C, Liu L, Huang J, Gong L, Li J, Zhang H, Chen J
International immunopharmacology 2024 Dec 25;143(Pt 3):113608
International immunopharmacology 2024 Dec 25;143(Pt 3):113608
Transcription factors PuNAC37/PuWRKY74 and E3 ubiquitin ligase PuRDUF2 inhibit volatile ester synthesis in 'Nanguo' pear.
Zang N, Li X, Zhang Z, Liu W, Qi L, Yang Y, Sun Q, Yin Z, Wang A
Plant physiology 2024 Dec 23;197(1)
Plant physiology 2024 Dec 23;197(1)
Nrf2/NRF1 signaling activation and crosstalk amplify mitochondrial biogenesis in the treatment of triptolide-induced cardiotoxicity using calycosin.
Qi XM, Zhang WZ, Zuo YQ, Qiao YB, Zhang YL, Ren JH, Li QS
Cell biology and toxicology 2024 Dec 20;41(1):2
Cell biology and toxicology 2024 Dec 20;41(1):2
NIR-715 photodynamic therapy induces immunogenic cancer cell death by enhancing the endoplasmic reticulum stress response.
Zheng ZY, Lin W, Su JW, Huang QF, Zhang C, Pan WX, Li EM, Zhang HF, Xu LY
Cell death & disease 2024 Dec 18;15(12):890
Cell death & disease 2024 Dec 18;15(12):890
RRM1 promotes homologous recombination and radio/chemo-sensitivity via enhancing USP11 and E2F1-mediated RAD51AP1 transcription.
Yang S, Wang R, Liu L, Xu F, Zhao X, Yao Z, Zhang J, Cheng X, Xu A, Wu L, Zhao G
Cell death discovery 2024 Dec 18;10(1):496
Cell death discovery 2024 Dec 18;10(1):496
Development of Novel Silicon-Based Hydrophobic Tags (SiHyT) for Targeted Proteins Degradation.
Ma L, Zhang K, Huang Z, Guo Y, Liu N, Chen J, Wang X, Liu Y, Li M, Li J, Yang C, Liu S, Yang G
Journal of medicinal chemistry 2024 Dec 12;67(23):21344-21363
Journal of medicinal chemistry 2024 Dec 12;67(23):21344-21363
GDF15 induces chemoresistance to oxaliplatin by forming a reciprocal feedback loop with Nrf2 to maintain redox homeostasis in colorectal cancer.
Lin H, Luo Y, Gong T, Fang H, Li H, Ye G, Zhang Y, Zhong M
Cellular oncology (Dordrecht, Netherlands) 2024 Aug;47(4):1149-1165
Cellular oncology (Dordrecht, Netherlands) 2024 Aug;47(4):1149-1165
USP19 Stabilizes TAK1 to Regulate High Glucose/Free Fatty Acid-induced Dysfunction in HK-2 Cells.
Yan XH, Zhu YN, Zhu YT
Current medical science 2024 Aug;44(4):707-717
Current medical science 2024 Aug;44(4):707-717
Deubiquitinating enzyme OTUD4 stabilizes RBM47 to induce ATF3 transcription: a novel mechanism underlying the restrained malignant properties of ccRCC cells.
Li Z, Tian Y, Zong H, Wang X, Li D, Keranmu A, Xin S, Ye B, Bai R, Chen W, Yang G, Ye L, Wang S
Apoptosis : an international journal on programmed cell death 2024 Aug;29(7-8):1051-1069
Apoptosis : an international journal on programmed cell death 2024 Aug;29(7-8):1051-1069
Polydatin attenuates diabetic renal inflammatory fibrosis via the inhibition of STING pathway.
Liang L, Zeng J, Liu R, Zheng Z, Lyu D, Zhang X, Wen M, Li M, Xiao H, Sun X, Li M, Huang H
Biochemical pharmacology 2024 Aug;226:116373
Biochemical pharmacology 2024 Aug;226:116373
Ubiquitin-specific peptidase 15 regulates the TFAP4/PCGF1 axis facilitating liver metastasis of colorectal cancer and cell stemness.
Yin H, Wu D, Qu Q, Li Z, Zhao L
Biochemical pharmacology 2024 Aug;226:116319
Biochemical pharmacology 2024 Aug;226:116319
The Deubiquitinase USP22-Stabilized COL17A1 Promotes Lung Adenocarcinoma Progression.
Chen G, Du D, Wang H, Li H
The clinical respiratory journal 2024 Aug;18(8):e13824
The clinical respiratory journal 2024 Aug;18(8):e13824
CircNCX1 modulates cardiomyocyte proliferation through promoting ubiquitination of BRG1.
Yijian L, Weihan S, Lin Y, Heng Z, Yu W, Lin S, Shuo M, Mengyang L, Jianxun W
Cellular signalling 2024 Aug;120:111193
Cellular signalling 2024 Aug;120:111193
Melatonin alleviates palmitic acid-induced mitochondrial dysfunction by reducing oxidative stress and enhancing autophagy in bovine endometrial epithelial cells.
Wang Y, Gong J, Heng N, Hu Y, Wang R, Wang H, He W, Zhu N, Hu Z, Hao H, Zhu H, Zhao S
Journal of animal science and biotechnology 2024 Aug 8;15(1):108
Journal of animal science and biotechnology 2024 Aug 8;15(1):108
A clinical-stage Nrf2 activator suppresses osteoclast differentiation via the iron-ornithine axis.
Dong Y, Kang H, Peng R, Liu Z, Liao F, Hu SA, Ding W, Wang P, Yang P, Zhu M, Wang S, Wu M, Ye D, Gan X, Li F, Song K
Cell metabolism 2024 Aug 6;36(8):1679-1695.e6
Cell metabolism 2024 Aug 6;36(8):1679-1695.e6
N-ethylmaleimide-sensitive factor elicits a neuroprotection against ischemic neuronal injury by restoring autophagic/lysosomal dysfunction.
Qiu M, Zhao X, Guo T, He H, Deng Y
Cell death discovery 2024 Aug 18;10(1):368
Cell death discovery 2024 Aug 18;10(1):368
SERPINH1 modulates apoptosis by inhibiting P62 ubiquitination degradation to promote bone metastasis of prostate cancer.
Tang C, Lai Y, Li L, Situ MY, Li S, Cheng B, Chen Y, Lei Z, Ren Y, Zhou J, Wu Y, Zhong H, Li K, Zeng L, Guo Z, Peng S, Huang H
iScience 2024 Aug 16;27(8):110427
iScience 2024 Aug 16;27(8):110427
Pyrogallol promotes growth arrest by activating the p53-mediated up-regulation of p21 and p62/SQSTM1-dependent degradation of β-catenin in nonsmall cell lung cancer cells.
Zhou B, Wang L, Ren Z, Liang Y, Yang S, Zhang Y, Che S, Fang W
Environmental toxicology 2024 Apr;39(4):2150-2165
Environmental toxicology 2024 Apr;39(4):2150-2165
APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy.
Du Y, Zhou Y, Yan X, Pan F, He L, Guo Z, Hu Z
Cell death and differentiation 2024 Apr;31(4):431-446
Cell death and differentiation 2024 Apr;31(4):431-446
STING deficiency alleviates ferroptosis through FPN1 stabilization in diabetic kidney disease.
Zhao QX, Yan SB, Wang F, Li XX, Shang GK, Zheng ZJ, Xiao J, Lin ZW, Li CB, Ji XP
Biochemical pharmacology 2024 Apr;222:116102
Biochemical pharmacology 2024 Apr;222:116102
Hydrogen sulfide improves endothelial barrier function by modulating the ubiquitination degradation of KLF4 through TRAF7 S-sulfhydration in diabetic aorta.
Li Q, Kang J, Liu N, Huang J, Zhang X, Pang K, Zhang S, Wang M, Zhao Y, Dong S, Li H, Zhao D, Lu F, Zhang W
Free radical biology & medicine 2024 Apr;216:118-138
Free radical biology & medicine 2024 Apr;216:118-138
p53 accelerates endothelial cell senescence in diabetic retinopathy by enhancing FoxO3a ubiquitylation and degradation via UBE2L6.
Cheng Y, Zhang M, Xu R, Fu L, Xue M, Xu C, Tang C, Fang T, Liu X, Sun B, Chen L
Experimental gerontology 2024 Apr;188:112391
Experimental gerontology 2024 Apr;188:112391
Spinal sirtuin 2 attenuates bone cancer pain by deacetylating FoxO3a.
Yang C, Kang F, Huang X, Wu W, Hou G, Zheng K, Han M, Kan B, Zhang Z, Li J
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167129
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167129
Chronic Rapamycin administration via drinking water mitigates the pathological phenotype in a Krabbe disease mouse model through autophagy activation.
Del Grosso A, Carpi S, De Sarlo M, Scaccini L, Colagiorgio L, Alabed HBR, Angella L, Pellegrino RM, Tonazzini I, Emiliani C, Cecchini M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Apr;173:116351
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Apr;173:116351
Fn-OMV potentiates ZBP1-mediated PANoptosis triggered by oncolytic HSV-1 to fuel antitumor immunity.
Wang S, Song A, Xie J, Wang YY, Wang WD, Zhang MJ, Wu ZZ, Yang QC, Li H, Zhang J, Sun ZJ
Nature communications 2024 Apr 30;15(1):3669
Nature communications 2024 Apr 30;15(1):3669
Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome.
Wu S, Dai X, Xia Y, Zhao Q, Zhao H, Shi Z, Yin X, Liu X, Zhang A, Yao Z, Zhang H, Li Q, Thorne RF, Zhang S, Sheng W, Hu W, Gu H
Cell reports 2024 Apr 23;43(4):114111
Cell reports 2024 Apr 23;43(4):114111
N6-methyladenosine-modified circSLCO1B3 promotes intrahepatic cholangiocarcinoma progression via regulating HOXC8 and PD-L1.
Li J, Xu X, Xu K, Zhou X, Wu K, Yao Y, Liu Z, Chen C, Wang L, Sun Z, Jiao D, Han X
Journal of experimental & clinical cancer research : CR 2024 Apr 20;43(1):119
Journal of experimental & clinical cancer research : CR 2024 Apr 20;43(1):119
Physalin H ameliorates LPS-induced acute lung injury via KEAP1/NRF2 axis.
Cai Y, Zhu J, Zhu L, Hong L, Zhang J, Kong L, Chen C, Luo J
International immunopharmacology 2024 Apr 20;131:111789
International immunopharmacology 2024 Apr 20;131:111789
Fatty liver disease protective MTARC1 p.A165T variant reduces the protein stability of MTARC1.
Wu M, Tie M, Hu L, Yang Y, Chen Y, Ferguson D, Chen Y, He A
Biochemical and biophysical research communications 2024 Apr 2;702:149655
Biochemical and biophysical research communications 2024 Apr 2;702:149655
An LRPPRC-HAPSTR1-PSMD14 interaction regulates tumor progression in ovarian cancer.
Li D, Wang M
Aging 2024 Apr 18;16(8):6773-6795
Aging 2024 Apr 18;16(8):6773-6795
Circ_005077 accelerates myocardial lipotoxicity induced by high-fat diet via CyPA/p47PHOX mediated ferroptosis.
Ni X, Duan L, Bao Y, Li J, Zhang X, Jia D, Wu N
Cardiovascular diabetology 2024 Apr 15;23(1):129
Cardiovascular diabetology 2024 Apr 15;23(1):129
FBXL8 inhibits post-myocardial infarction cardiac fibrosis by targeting Snail1 for ubiquitin-proteasome degradation.
Li Y, Zuo C, Wu X, Ding Y, Wei Y, Chen S, Lu X, Xu J, Liu S, Zhou G, Cai L
Cell death & disease 2024 Apr 13;15(4):263
Cell death & disease 2024 Apr 13;15(4):263
Acidosis activates breast cancer ferroptosis through ZFAND5/SLC3A2 signaling axis and elicits M1 macrophage polarization.
Xiong H, Zhai Y, Meng Y, Wu Z, Qiu A, Cai Y, Wang G, Yang L
Cancer letters 2024 Apr 10;587:216732
Cancer letters 2024 Apr 10;587:216732
Murine Myoblasts Exposed to SYUIQ-5 Acquire Senescence Phenotype and Differentiate into Sarcopenic-Like Myotubes, an In Vitro Study.
Gerosa L, Malvandi AM, Gomarasca M, Verdelli C, Sansoni V, Faraldi M, Ziemann E, Olivieri F, Banfi G, Lombardi G
The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Apr 1;79(4)
The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Apr 1;79(4)
Phosphorylation by IKKβ Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer.
Zhong C, Xiong G, Yang H, Du X, Du J, Yao F, Fang W, Deng Y
International journal of biological sciences 2023;19(4):1110-1122
International journal of biological sciences 2023;19(4):1110-1122
NLRP3 Regulates Mandibular Healing through Interaction with UCHL5 in MSCs.
Zhao W, Cao Y, Chen Y, Chen Y, Wang T, Li L, Xu Y, Yuan H, Wang H, Wang R, Sun W
International journal of biological sciences 2023;19(3):936-949
International journal of biological sciences 2023;19(3):936-949
Nicotinamide adenine dinucleotide kinase promotes lymph node metastasis of NSCLC via activating ID1 expression through BMP pathway.
Zeng Z, Gao J, Chen T, Zhang Z, Li M, Fan Q, Liu G, Li X, Li Z, Zhong C, Yao F, Sun L, Deng Y, Li M
International journal of biological sciences 2023;19(10):3184-3199
International journal of biological sciences 2023;19(10):3184-3199
Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6.
Yu C, Zhu Q, Ma C, Luo C, Nie L, Cai H, Wang Q, Wang F, Ren H, Yan H, Xu K, Zhou L, Zhang C, Lu G, Lu Z, Zhu Y, Liu S
Frontiers in immunology 2023;14:1289795
Frontiers in immunology 2023;14:1289795
UBE2S targets RPL26 for ubiquitination and degradation to promote non-small cell lung cancer progression via regulating c-Myc.
Gong D, Rao X, Min Z, Liu X, Xin H, Zhou P, Yang L, Li D
American journal of cancer research 2023;13(8):3705-3720
American journal of cancer research 2023;13(8):3705-3720
NPM1 promotes nasopharyngeal carcinoma metastasis and stemness by recruiting Mdm2 to induce the ubiquitination-mediated degradation of p53.
Hu L, Gong P, Zhou N, Wang S, He C, Zhou Y, Li Q, Zhao X, Peng H
American journal of cancer research 2023;13(5):1766-1785
American journal of cancer research 2023;13(5):1766-1785
Fangchinoline alleviates cognitive impairments through enhancing autophagy and mitigating oxidative stress in Alzheimer's disease models.
Yi L, Luo M, Wang M, Dong Z, Du Y
Frontiers in cell and developmental biology 2023;11:1288506
Frontiers in cell and developmental biology 2023;11:1288506
EVC-EVC2 complex stability and ciliary targeting are regulated by modification with ubiquitin and SUMO.
Barbeito P, Martin-Morales R, Palencia-Campos A, Cerrolaza J, Rivas-Santos C, Gallego-Colastra L, Caparros-Martin JA, Martin-Bravo C, Martin-Hurtado A, Sánchez-Bellver L, Marfany G, Ruiz-Perez VL, Garcia-Gonzalo FR
Frontiers in cell and developmental biology 2023;11:1190258
Frontiers in cell and developmental biology 2023;11:1190258
E3 ligase ATL5 positively regulates seed longevity by mediating the degradation of ABT1 in Arabidopsis.
He W, Wang R, Zhang Q, Fan M, Lyu Y, Chen S, Chen D, Chen X
The New phytologist 2023 Sep;239(5):1754-1770
The New phytologist 2023 Sep;239(5):1754-1770
EGFR-T790M Mutation-Derived Interactome Rerouted EGFR Translocation Contributing to Gefitinib Resistance in Non-Small Cell Lung Cancer.
Wu PS, Lin MH, Hsiao JC, Lin PY, Pan SH, Chen YJ
Molecular & cellular proteomics : MCP 2023 Sep;22(9):100624
Molecular & cellular proteomics : MCP 2023 Sep;22(9):100624
Hepatocyte CD36 modulates UBQLN1-mediated proteasomal degradation of autophagic SNARE proteins contributing to septic liver injury.
Li Y, Xu J, Chen W, Wang X, Zhao Z, Li Y, Zhang L, Jiao J, Yang Q, Ding Q, Yang P, Wei L, Chen Y, Chen Y, Ruan XZ, Zhao L
Autophagy 2023 Sep;19(9):2504-2519
Autophagy 2023 Sep;19(9):2504-2519
Triiodothyronine positively regulates endoplasmic reticulum-associated degradation (ERAD) and promotes androgenic signaling in androgen-dependent prostate cancer cells.
Erzurumlu Y, Muhammed MT
Cellular signalling 2023 Sep;109:110745
Cellular signalling 2023 Sep;109:110745
GART Functions as a Novel Methyltransferase in the RUVBL1/β-Catenin Signaling Pathway to Promote Tumor Stemness in Colorectal Cancer.
Tang C, Ke M, Yu X, Sun S, Luo X, Liu X, Zhou Y, Wang Z, Cui X, Gu C, Yang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(25):e2301264
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(25):e2301264
The NLRP11 Protein Bridges the Histone Lysine Acetyltransferase KAT7 to Acetylate Vimentin in the Early Stage of Lung Adenocarcinoma.
Yang R, Peng W, Shi S, Peng X, Cai Q, Zhao Z, He B, Tu G, Yin W, Chen Y, Zhang Y, Liu F, Wang X, Xiao D, Tao Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(25):e2300971
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(25):e2300971
Phosphorylation of PPDPF via IL6-JAK2 activates the Wnt/β-catenin pathway in colorectal cancer.
Zi Y, Liu L, Gao J, Xu X, Guan Y, Rong Z, Cao Z, Li M, Zeng Z, Fan Q, Tang F, He J, Feng D, Chen J, Dai Y, Huang Y, Nie Y, Pei H, Cai Q, Li Z, Sun L, Deng Y
EMBO reports 2023 Sep 6;24(9):e55060
EMBO reports 2023 Sep 6;24(9):e55060
MDM2 upregulation induces mitophagy deficiency via Mic60 ubiquitination in fetal microglial inflammation and consequently neuronal DNA damage caused by exposure to ZnO-NPs during pregnancy.
Zhang Y, Zhang Y, Lei Y, Wu J, Kang Y, Zheng S, Shao L
Journal of hazardous materials 2023 Sep 5;457:131750
Journal of hazardous materials 2023 Sep 5;457:131750
Arabidopsis PLANT U-BOX44 down-regulates osmotic stress signaling by mediating Ca2+-DEPENDENT PROTEIN KINASE4 degradation.
Fan W, Liao X, Tan Y, Wang X, Schroeder JI, Li Z
The Plant cell 2023 Sep 27;35(10):3870-3888
The Plant cell 2023 Sep 27;35(10):3870-3888
ITCH-Mediated Ubiquitylation of ITGB3 Promotes Cell Proliferation and Invasion of Ectopic Endometrial Stromal Cells in Ovarian Endometriosis.
Zhang L, Shao W, Li M, Liu S
Biomedicines 2023 Sep 11;11(9)
Biomedicines 2023 Sep 11;11(9)
Loss of hepatic FTCD promotes lipid accumulation and hepatocarcinogenesis by upregulating PPARγ and SREBP2.
Wang S, Zhou Y, Yu R, Ling J, Li B, Yang C, Cheng Z, Qian R, Lin Z, Yu C, Zheng J, Zheng X, Jia Q, Wu W, Wu Q, Chen M, Yuan S, Dong W, Shi Y, Jansen R, Yang C, Hao Y, Yao M, Qin W, Jin H
JHEP reports : innovation in hepatology 2023 Oct;5(10):100843
JHEP reports : innovation in hepatology 2023 Oct;5(10):100843
TMED2 Induces Cisplatin Resistance in Breast Cancer via Targeting the KEAP1-Nrf2 Pathway.
Liang C, Zhang HY, Wang YQ, Yang LA, Du YS, Luo Y, Zhang TC, Xu Y
Current medical science 2023 Oct;43(5):1023-1032
Current medical science 2023 Oct;43(5):1023-1032
Parkin regulates IGF2BP3 through ubiquitination in the tumourigenesis of cervical cancer.
Sun X, Ye G, Li J, Shou H, Bai G, Zhang J
Clinical and translational medicine 2023 Oct;13(10):e1457
Clinical and translational medicine 2023 Oct;13(10):e1457
UV-B irradiation-activated E3 ligase GmILPA1 modulates gibberellin catabolism to increase plant height in soybean.
Sun J, Huang S, Lu Q, Li S, Zhao S, Zheng X, Zhou Q, Zhang W, Li J, Wang L, Zhang K, Zheng W, Feng X, Liu B, Kong F, Xiang F
Nature communications 2023 Oct 7;14(1):6262
Nature communications 2023 Oct 7;14(1):6262
Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.
Wang M, Tang J, Zhang S, Pang K, Zhao Y, Liu N, Huang J, Kang J, Dong S, Li H, Tian Z, Duan B, Lu F, Zhang W
Cell death discovery 2023 Oct 24;9(1):394
Cell death discovery 2023 Oct 24;9(1):394
TRIM21 mediates the synergistic effect of Olaparib and Sorafenib by degrading BRCA1 through ubiquitination in TNBC.
Huang N, Li P, Sun X, Tong L, Dong X, Zhang X, Duan J, Sheng X, Xin H
NPJ breast cancer 2023 Oct 20;9(1):85
NPJ breast cancer 2023 Oct 20;9(1):85
PIWI-interacting RNA expression regulates pathogenesis in a Caenorhabditis elegans model of Lewy body disease.
Huang X, Wang C, Zhang T, Li R, Chen L, Leung KL, Lakso M, Zhou Q, Zhang H, Wong G
Nature communications 2023 Oct 2;14(1):6137
Nature communications 2023 Oct 2;14(1):6137
TRAF7-targeted HOXA5 acts as a tumor suppressor in prostate cancer progression and stemness via transcriptionally activating SPRY2 and regulating MEK/ERK signaling.
Ye J, Liu W, Yu X, Wu L, Chen Z, Yu Y, Wang J, Bai S, Zhang M
Cell death discovery 2023 Oct 16;9(1):378
Cell death discovery 2023 Oct 16;9(1):378
Mitigating a TDP-43 proteinopathy by targeting ataxin-2 using RNA-targeting CRISPR effector proteins.
Zeballos C MA, Moore HJ, Smith TJ, Powell JE, Ahsan NS, Zhang S, Gaj T
Nature communications 2023 Oct 14;14(1):6492
Nature communications 2023 Oct 14;14(1):6492
DEPDC1B-mediated USP5 deubiquitination of β-catenin promotes breast cancer metastasis by activating the wnt/β-catenin pathway.
Wang Q, Chen F, Yang N, Xu L, Yu X, Wu M, Zhou Y
American journal of physiology. Cell physiology 2023 Oct 1;325(4):C833-C848
American journal of physiology. Cell physiology 2023 Oct 1;325(4):C833-C848
Polydopamine-loaded prunetin nanomaterials activate DRD2 to reduce UV-induced inflammation by stabilizing and promoting Nrf2 nuclear translocation.
Han J, Zheng S, Jin J, Wu T, Shi Y, Yang K, Zhang H, Li Y, Sun Y, Lv Y, Yao C, Lin T, Zhu C, Liu H
Acta biomaterialia 2023 Oct 1;169:556-565
Acta biomaterialia 2023 Oct 1;169:556-565
UFMylation of HRD1 regulates endoplasmic reticulum homeostasis.
Luo H, Jiao QB, Shen CB, Gong WY, Yuan JH, Liu YY, Chen Z, Liu J, Xu XL, Cong YS, Zhang XW
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Nov;37(11):e23221
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Nov;37(11):e23221
USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A.
Mu M, Zhang Q, Li J, Zhao C, Li X, Chen Z, Sun X, Yu J
Cell death and differentiation 2023 Nov;30(11):2393-2407
Cell death and differentiation 2023 Nov;30(11):2393-2407
Targeting TLK2 inhibits the progression of gastric cancer by reprogramming amino acid metabolism through the mTOR/ASNS axis.
Wang M, Li J, Yang X, Yan Q, Wang H, Xu X, Lu Y, Li D, Wang Y, Sun R, Zhang S, Zhang Y, Zhang Z, Meng F, Li Y
Cancer gene therapy 2023 Nov;30(11):1485-1497
Cancer gene therapy 2023 Nov;30(11):1485-1497
Orosomucoid proteins limit endoplasmic reticulum stress in plants.
Wang LY, Li J, Gong B, Wang RH, Chen YL, Yin J, Yang C, Lin JT, Liu HZ, Yang Y, Li J, Li C, Yao N
The New phytologist 2023 Nov;240(3):1134-1148
The New phytologist 2023 Nov;240(3):1134-1148
Dl-3-n-butylphthalide exerts neuroprotective effects by modulating hypoxia-inducible factor 1-alpha ubiquitination to attenuate oxidative stress-induced apoptosis.
Li S, Zhao J, Xi Y, Ren J, Zhu Y, Lu Y, Dong D
Neural regeneration research 2023 Nov;18(11):2424-2428
Neural regeneration research 2023 Nov;18(11):2424-2428
Combination of PARP inhibitor and CDK4/6 inhibitor modulates cGAS/STING-dependent therapy-induced senescence and provides "one-two punch" opportunity with anti-PD-L1 therapy in colorectal cancer.
Wang T, Liu W, Shen Q, Tao R, Li C, Shen Q, Lin Y, Huang Y, Yang L, Xie G, Bai J, Li R, Wang L, Tao K, Yin Y
Cancer science 2023 Nov;114(11):4184-4201
Cancer science 2023 Nov;114(11):4184-4201
Downregulation of pro-surfactant protein B contributes to the recurrence of early-stage non-small cell lung cancer by activating PGK1-mediated Akt signaling.
Luo H, Li Q, Wang RT, Zhang L, Zhang W, Deng MS, Luo YY, Ji X, Wen Y, Zhou XR, Xu B, Wang D, Hu B, Jin H, Xu CX
Experimental hematology & oncology 2023 Nov 9;12(1):94
Experimental hematology & oncology 2023 Nov 9;12(1):94
The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer.
Khalil MI, Yang C, Vu L, Chadha S, Nabors H, James CD, Morgan IM, Pyeon D
bioRxiv : the preprint server for biology 2023 Nov 4;
bioRxiv : the preprint server for biology 2023 Nov 4;
Fucoidan Ameliorates Ferroptosis in Ischemia-reperfusion-induced Liver Injury through Nrf2/HO-1/GPX4 Activation.
Li JJ, Dai WQ, Mo WH, Xu WQ, Li YY, Guo CY, Xu XF
Journal of clinical and translational hepatology 2023 Nov 28;11(6):1341-1354
Journal of clinical and translational hepatology 2023 Nov 28;11(6):1341-1354
Metformin Suppresses Stemness of Non-Small-Cell Lung Cancer Induced by Paclitaxel through FOXO3a.
Tang Z, Zhang Y, Yu Z, Luo Z
International journal of molecular sciences 2023 Nov 22;24(23)
International journal of molecular sciences 2023 Nov 22;24(23)
Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway.
Fu Y, Jia Q, Ren M, Bie H, Zhang X, Zhang Q, He S, Li C, Zhou H, Wang Y, Gan X, Tao Z, Chen X, Jia E
Immunity & ageing : I & A 2023 Nov 21;20(1):66
Immunity & ageing : I & A 2023 Nov 21;20(1):66
FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression.
Hu WM, Li M, Ning JZ, Tang YQ, Song TB, Li LZ, Zou F, Cheng F, Yu WM
Journal of experimental & clinical cancer research : CR 2023 Nov 2;42(1):290
Journal of experimental & clinical cancer research : CR 2023 Nov 2;42(1):290
Cullin 5 aggravates hypoxic pulmonary hypertension by activating TRAF6/NF-κB/HIF-1α/VEGF.
Wang L, Huang J, Zhang R, Zhang M, Guo Y, Liu Y, Li C, Wang W, Ying S, Liu J, Wang C
iScience 2023 Nov 17;26(11):108199
iScience 2023 Nov 17;26(11):108199
CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signaling pathway.
Li Y, Fan S, Kong L, Hao Z, Zhou Y, Shangguan J, Gao L, Wang M, Kang Y, Li X, Huang K, Zhang C, Liu Z
iScience 2023 Nov 17;26(11):108070
iScience 2023 Nov 17;26(11):108070
Intrathecal delivery of AAV-NDNF ameliorates disease progression of ALS mice.
Cheng W, Huang J, Fu XQ, Tian WY, Zeng PM, Li Y, Luo ZG
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Nov 1;31(11):3277-3289
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Nov 1;31(11):3277-3289
FGF21 protects against doxorubicin-induced cardiotoxicity by inhibiting connexin 43 ubiquitination.
Huang Y, Wei C, Li P, Shao Y, Wang M, Wang F, Niu G, Sun K, Zhang Q, Gou Z, Yan X
Free radical biology & medicine 2023 Nov 1;208:748-758
Free radical biology & medicine 2023 Nov 1;208:748-758
Molecular functions of the double-sided and inverted ubiquitin-interacting motif found in Xenopus tropicalis cryptochrome 6.
Okano K, Otsuka H, Nakagawa M, Okano T
Development, growth & differentiation 2023 May;65(4):203-214
Development, growth & differentiation 2023 May;65(4):203-214
OTUB1 Catalytic-Independently Deubiquitinates TGFBI and Mediates the Angiogenesis in Infantile Hemangioma by Regulating Glycolysis.
Li M, Wang X, Yang E, Li Y, Geng Y, Chen Z, Huang S, Zhang D, Wu H
Arteriosclerosis, thrombosis, and vascular biology 2023 May;43(5):654-673
Arteriosclerosis, thrombosis, and vascular biology 2023 May;43(5):654-673
Polydopamine Nanoparticles Targeting Ferroptosis Mitigate Intervertebral Disc Degeneration Via Reactive Oxygen Species Depletion, Iron Ions Chelation, and GPX4 Ubiquitination Suppression.
Yang X, Chen Y, Guo J, Li J, Zhang P, Yang H, Rong K, Zhou T, Fu J, Zhao J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(13):e2207216
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(13):e2207216
miR-137-LAPTM4B regulates cytoskeleton organization and cancer metastasis via the RhoA-LIMK-Cofilin pathway in osteosarcoma.
Yan R, Liu D, Wang J, Liu M, Guo H, Bai J, Yang S, Chang J, Yao Z, Yang Z, Blom T, Zhou K
Oncogenesis 2023 May 6;12(1):25
Oncogenesis 2023 May 6;12(1):25
The oncogenic role of NF1 in gallbladder cancer through regulation of YAP1 stability by direct interaction with YAP1.
Zhang L, Jiang L, Zeng L, Jin Z, Dong X, Zhang Y, Chen L, Shu Y, Liu Y, Huang Y
Journal of translational medicine 2023 May 5;21(1):306
Journal of translational medicine 2023 May 5;21(1):306
SYTL2 promotes metastasis of prostate cancer cells by enhancing FSCN1-mediated pseudopodia formation and invasion.
Li Z, Tao Y, Gao Z, Peng S, Lai Y, Li K, Chen X, Huang H
Journal of translational medicine 2023 May 5;21(1):303
Journal of translational medicine 2023 May 5;21(1):303
HDAC4 mediated LHPP deacetylation enhances its destabilization and promotes the proliferation and metastasis of nasopharyngeal carcinoma.
Sun X, Zhang K, Peng X, Zhou P, Qu C, Yang L, Shen L
Cancer letters 2023 May 28;562:216158
Cancer letters 2023 May 28;562:216158
RSL1D1 knockdown induces ferroptosis and mediates ferrous iron accumulation in senescent cells by inhibiting FTH1 mRNA stability.
Jin Y, Zhao L, Wang S, Zhang X, Quan J, Lin Z, Piao J
Carcinogenesis 2023 May 26;44(2):129-142
Carcinogenesis 2023 May 26;44(2):129-142
Downregulation of Histone H4 Lysine 16 Acetylation Ameliorates Autophagic Flux by Resuming Lysosomal Functions in Ischemic Neurons.
Yuyuan L, Xiaoming Z, Lei Z, Tao G, Hongyun H, Yihao D
ACS chemical neuroscience 2023 May 17;14(10):1834-1844
ACS chemical neuroscience 2023 May 17;14(10):1834-1844
TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury.
Sun X, Huang N, Li P, Dong X, Yang J, Zhang X, Zong WX, Gao S, Xin H
Life sciences 2023 May 15;321:121608
Life sciences 2023 May 15;321:121608
p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors.
Li WF, Alfason L, Huang C, Tang Y, Qiu L, Miyagishi M, Wu SR, Kasim V
Acta pharmacologica Sinica 2023 Mar;44(3):647-660
Acta pharmacologica Sinica 2023 Mar;44(3):647-660
Deubiquitinating enzyme USP11 promotes renal tubular cell senescence and fibrosis via inhibiting the ubiquitin degradation of TGF-β receptor II.
Ni JY, Wang X, Xie HY, Yang NH, Li JY, Sun XA, Guo HJ, Zhou L, Zhang W, Liu J, Lu LM
Acta pharmacologica Sinica 2023 Mar;44(3):584-595
Acta pharmacologica Sinica 2023 Mar;44(3):584-595
MYB30 integrates light signals with antioxidant biosynthesis to regulate plant responses during postsubmergence recovery.
Xie LJ, Wang JH, Liu HS, Yuan LB, Tan YF, Tan WJ, Zhou Y, Chen QF, Qi H, Li JF, Chen YQ, Qiu RL, Chen MX, Xiao S
The New phytologist 2023 Mar;237(6):2238-2254
The New phytologist 2023 Mar;237(6):2238-2254
S1PR1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lung.
Hao M, Fu R, Tai J, Tian Z, Yuan X, Chen Y, Wang M, Jiang H, Ji M, Lai F, Xue N, Bai L, Zhu Y, Lv X, Chen X, Jin J
Acta pharmaceutica Sinica. B 2023 Mar;13(3):1110-1127
Acta pharmaceutica Sinica. B 2023 Mar;13(3):1110-1127
1,25(OH)(2) D(3) induced vitamin D receptor signaling negatively regulates endoplasmic reticulum-associated degradation (ERAD) and androgen receptor signaling in human prostate cancer cells.
Erzurumlu Y, Aydogdu E, Dogan HK, Catakli D, Muhammed MT, Buyuksandic B
Cellular signalling 2023 Mar;103:110577
Cellular signalling 2023 Mar;103:110577
Ribosome Biogenesis Regulator 1 Homolog (RRS1) Promotes Cisplatin Resistance by Regulating AEG-1 Abundance in Breast Cancer Cells.
Song J, Peng C, Wang R, Hua Y, Wu Q, Deng L, Cao Y, Zhang L, Hou L
Molecules (Basel, Switzerland) 2023 Mar 25;28(7)
Molecules (Basel, Switzerland) 2023 Mar 25;28(7)
De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics.
Rowland LA, Guilherme A, Henriques F, DiMarzio C, Munroe S, Wetoska N, Kelly M, Reddig K, Hendricks G, Pan M, Han X, Ilkayeva OR, Newgard CB, Czech MP
Nature communications 2023 Mar 13;14(1):1362
Nature communications 2023 Mar 13;14(1):1362
Potent carotenoid astaxanthin expands the anti-cancer activity of cisplatin in human prostate cancer cells.
Erzurumlu Y, Catakli D, Dogan HK
Journal of natural medicines 2023 Jun;77(3):572-583
Journal of natural medicines 2023 Jun;77(3):572-583
The Valsa Mali effector Vm1G-1794 protects the aggregated MdEF-Tu from autophagic degradation to promote infection in apple.
Che R, Liu C, Wang Q, Tu W, Wang P, Li C, Gong X, Mao K, Feng H, Huang L, Li P, Ma F
Autophagy 2023 Jun;19(6):1745-1763
Autophagy 2023 Jun;19(6):1745-1763
Intrahippocampal injection of IL-1β upregulates Siah1-mediated degradation of synaptophysin by activation of the ERK signaling in male rat.
Zhou Q, Lin L, Li H, Li Y, Liu N, Wang H, Jiang S, Li Q, Chen Z, Lin Y, Jin H, Deng Y
Journal of neuroscience research 2023 Jun;101(6):930-951
Journal of neuroscience research 2023 Jun;101(6):930-951
Apo- and holo-transferrin differentially interact with hephaestin and ferroportin in a novel mechanism of cellular iron release regulation.
Baringer SL, Palsa K, Spiegelman VS, Simpson IA, Connor JR
Journal of biomedical science 2023 Jun 6;30(1):36
Journal of biomedical science 2023 Jun 6;30(1):36
Albumosomes formed by cytoplasmic pre-folding albumin maintain mitochondrial homeostasis and inhibit nonalcoholic fatty liver disease.
Ma B, Ju A, Zhang S, An Q, Xu S, Liu J, Yu L, Fu Y, Luo Y
Signal transduction and targeted therapy 2023 Jun 16;8(1):229
Signal transduction and targeted therapy 2023 Jun 16;8(1):229
Cathepsin K promotes the proliferation of hepatocellular carcinoma cells through induction of SIAH1 ubiquitination and degradation.
Zhang C, Liu Z, Wang X, Zhang B, Cui L, Hu Q, Hu B, Cao K, Shan W, Shi H, Wang R
iScience 2023 Jun 16;26(6):106852
iScience 2023 Jun 16;26(6):106852
Selenoprotein P deficiency protects against immobilization-induced muscle atrophy by suppressing atrophy-related E3 ubiquitin ligases.
Abuduwaili H, Kamoshita K, Ishii KA, Takahashi K, Abuduyimiti T, Qifang L, Isobe Y, Goto H, Nakano Y, Takeshita Y, Takayama H, Harada K, Takamura T
American journal of physiology. Endocrinology and metabolism 2023 Jun 1;324(6):E542-E552
American journal of physiology. Endocrinology and metabolism 2023 Jun 1;324(6):E542-E552
ASPM promotes migration and invasion of anaplastic thyroid carcinoma by stabilizing KIF11.
Fang Q, Li Q, Qi Y, Pan Z, Feng T, Xin W
Cell biology international 2023 Jul;47(7):1209-1221
Cell biology international 2023 Jul;47(7):1209-1221
Dexamethasone-stimulated glucocorticoid receptor signaling positively regulates the endoplasmic reticulum-associated degradation (ERAD) mechanism in hepatocellular carcinoma cells.
Erzurumlu Y, Dogan HK, Cataklı D
Steroids 2023 Jul;195:109238
Steroids 2023 Jul;195:109238
Complex metabolic disharmony in PMM2-CDG paves the way to new therapeutic approaches.
Himmelreich N, Kikul F, Zdrazilova L, Honzik T, Hecker A, Poschet G, Lüchtenborg C, Brügger B, Strahl S, Bürger F, Okun JG, Hansikova H, Thiel C
Molecular genetics and metabolism 2023 Jul;139(3):107610
Molecular genetics and metabolism 2023 Jul;139(3):107610
USP51 promotes non-small cell lung carcinoma cell stemness by deubiquitinating TWIST1.
Chen J, Wu Z, Deng W, Tang M, Wu L, Lin N, Chen L, Fu Y, Zhao M, Chen C, Li W
Journal of translational medicine 2023 Jul 8;21(1):453
Journal of translational medicine 2023 Jul 8;21(1):453
Polyphyllin D punctures hypertrophic lysosomes to reverse drug resistance of hepatocellular carcinoma by targeting acid sphingomyelinase.
Wang Y, Chen YY, Gao GB, Zheng YH, Yu NN, Ouyang L, Gao X, Li N, Wen SY, Huang S, Zhao Q, Liu L, Cao M, Zhang S, Zhang J, He QY
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Jul 5;31(7):2169-2187
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Jul 5;31(7):2169-2187
Kaempferol inhibits non-homologous end joining repair via regulating Ku80 stability in glioma cancer.
Chen M, Zhao E, Li M, Xu M, Hao S, Gao Y, Wu X, Li X, Yu Y, Yu Z, Yin Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154876
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154876
STUB1-mediated ubiquitination regulates the stability of GLUD1 in lung adenocarcinoma.
Hu Q, Lei J, Cheng Z, Xu J, Wang L, Yuan Y, Gan M, Wang Y, Xie Y, Yao L, Wang K, Liu Y, Xun W, Wang JB, Han T
iScience 2023 Jul 21;26(7):107151
iScience 2023 Jul 21;26(7):107151
A novel variant in the FBP1 gene causes fructose-1,6-bisphosphatase deficiency through increased ubiquitination.
Liang X, Liu X, Li W, Zhang L, Zhang B, Lai G, Zhao Y
Archives of biochemistry and biophysics 2023 Jul 1;742:109619
Archives of biochemistry and biophysics 2023 Jul 1;742:109619
Combinations of ivermectin with proteasome inhibitors induce synergistic lethality in multiple myeloma.
Luo H, Feng Y, Wang F, Lin Z, Huang J, Li Q, Wang X, Liu X, Zhai X, Gao Q, Li L, Zhang Y, Wen J, Zhang L, Niu T, Zheng Y
Cancer letters 2023 Jul 1;565:216218
Cancer letters 2023 Jul 1;565:216218
CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization.
Qian K, Tol MJ, Wu J, Uchiyama LF, Xiao X, Cui L, Bedard AH, Weston TA, Rajendran PS, Vergnes L, Shimanaka Y, Yin Y, Jami-Alahmadi Y, Cohn W, Bajar BT, Lin CH, Jin B, DeNardo LA, Black DL, Whitelegge JP, Wohlschlegel JA, Reue K, Shivkumar K, Chen FJ, Young SG, Li P, Tontonoz P
Nature 2023 Jan;613(7942):160-168
Nature 2023 Jan;613(7942):160-168
Multi-proteomic Analysis Revealed Distinct Protein Profiles in Cerebrospinal Fluid of Patients Between Anti-NMDAR Encephalitis NORSE and Cryptogenic NORSE.
Wang D, Wu Y, Pan Y, Wang S, Liu G, Gao Y, Xu K
Molecular neurobiology 2023 Jan;60(1):98-115
Molecular neurobiology 2023 Jan;60(1):98-115
Fzr regulates silk gland growth by promoting endoreplication and protein synthesis in the silkworm.
Qian W, Li H, Zhang X, Tang Y, Yuan D, Huang Z, Cheng D
PLoS genetics 2023 Jan;19(1):e1010602
PLoS genetics 2023 Jan;19(1):e1010602
PD-L1 upregulation promotes drug-induced pulmonary fibrosis by inhibiting vimentin degradation.
Li Q, Deng MS, Wang RT, Luo H, Luo YY, Zhang DD, Chen KJ, Cao XF, Yang GM, Zhao TM, Xu B, Xu CX, Wang JM
Pharmacological research 2023 Jan;187:106636
Pharmacological research 2023 Jan;187:106636
PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms.
He Y, B'nai Taub A, Yu L, Yao Y, Zhang R, Zahr T, Aaron N, LeSauter J, Fan L, Liu L, Tazebay R, Que J, Pajvani U, Wang L, Silver R, Qiang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jan;10(2):e2204190
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jan;10(2):e2204190
Ring domains are essential for GATOR2-dependent mTORC1 activation.
Jiang C, Dai X, He S, Zhou H, Fang L, Guo J, Liu S, Zhang T, Pan W, Yu H, Fu T, Li D, Inuzuka H, Wang P, Xiao J, Wei W
Molecular cell 2023 Jan 5;83(1):74-89.e9
Molecular cell 2023 Jan 5;83(1):74-89.e9
UCHL3 promotes cervical cancer development and metastasis by stabilizing NRF2 via deubiquitination.
Zhang Y, Liu JB, Liu J, Liu M, Liu HL, Zhang J
Biochemical and biophysical research communications 2023 Jan 22;641:132-138
Biochemical and biophysical research communications 2023 Jan 22;641:132-138
Progesterone regulates the endoplasmic reticulum-associated degradation and Unfolded Protein Response axis by mimicking the androgenic stimulation in prostate cancer cells.
Erzurumlu Y, Dogan HK, Catakli D
Molecular biology reports 2023 Feb;50(2):1253-1265
Molecular biology reports 2023 Feb;50(2):1253-1265
Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.
Cao YF, Xie L, Tong BB, Chu MY, Shi WQ, Li X, He JZ, Wang SH, Wu ZY, Deng DX, Zheng YQ, Li ZM, Xu XE, Liao LD, Cheng YW, Li LY, Xu LY, Li EM
Cell death and differentiation 2023 Feb;30(2):527-543
Cell death and differentiation 2023 Feb;30(2):527-543
SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1.
Wang D, Liang W, Huo D, Wang H, Wang Y, Cong C, Zhang C, Yan S, Gao M, Su X, Tan X, Zhang W, Han L, Zhang D, Feng H
Cell death and differentiation 2023 Feb;30(2):369-382
Cell death and differentiation 2023 Feb;30(2):369-382
mascRNA alleviates STING-TBK1 signaling-mediated immune response through promoting ubiquitination of STING.
Hu Y, Li X, Wang D, Mao X
Molecular immunology 2023 Feb;154:45-53
Molecular immunology 2023 Feb;154:45-53
Neocryptotanshinone protects against myocardial ischemia-reperfusion injury by promoting autolysosome degradation of protein aggregates via the ERK1/2-Nrf2-LAMP2 pathway.
Yang Y, Shao M, Yao J, Yang S, Cheng W, Ma L, Li W, Cao J, Zhang Y, Hu Y, Li C, Wang Y, Wang W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154625
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154625
RBX1 regulates PKM alternative splicing to facilitate anaplastic thyroid carcinoma metastasis and aerobic glycolysis by destroying the SMAR1/HDAC6 complex.
Xu D, Yu J, Yang Y, Du Y, Lu H, Zhang S, Feng Q, Yu Y, Hao L, Shao J, Chen L
Cell & bioscience 2023 Feb 21;13(1):36
Cell & bioscience 2023 Feb 21;13(1):36
Rho A/ROCK1 signaling-mediated metabolic reprogramming of valvular interstitial cells toward Warburg effect accelerates aortic valve calcification via AMPK/RUNX2 axis.
Liu H, Yin H, Wang Z, Yuan Q, Xu F, Chen Y, Li C
Cell death & disease 2023 Feb 11;14(2):108
Cell death & disease 2023 Feb 11;14(2):108
UBE2E2 enhances Snail-mediated epithelial-mesenchymal transition and Nrf2-mediated antioxidant activity in ovarian cancer.
Hong X, Ma N, Li D, Zhang M, Dong W, Huang J, Ci X, Zhang S
Cell death & disease 2023 Feb 10;14(2):100
Cell death & disease 2023 Feb 10;14(2):100
FSIP1 enhances the therapeutic sensitivity to CDK4/6 inhibitors in triple-negative breast cancer patients by activating the Nanog pathway.
Chen G, Sun L, Gu X, Ai L, Yang J, Zhang Z, Hou P, Wang Y, Ou X, Jiang X, Qiao X, Ma Q, Niu N, Xue J, Zhang H, Yang Y, Liu C
Science China. Life sciences 2023 Dec;66(12):2805-2817
Science China. Life sciences 2023 Dec;66(12):2805-2817
USP10 promotes intrahepatic cholangiocarcinoma cell survival and stemness via SNAI1 deubiquitination.
Zhu W, Ye B, Yang S, Li Y
Journal of molecular histology 2023 Dec;54(6):703-714
Journal of molecular histology 2023 Dec;54(6):703-714
Mutual regulation between TRIM21 and TRIM8 via K48-linked ubiquitination.
Wang L, Li H, Huang A, Zhao Y, Xiao C, Dong J, Liu X, Shao N
Oncogene 2023 Dec;42(50):3708-3718
Oncogene 2023 Dec;42(50):3708-3718
Hypoxia-sensing VGLL4 promotes LDHA-driven lactate production to ameliorate neuronal dysfunction in a cellular model relevant to Alzheimer's disease.
Tian Q, Li J, Wu B, Wang J, Xiao Q, Tian N, Yi L, Luo M, Li Z, Pang Y, Shi X, Dong Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23290
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23290
Exogenous H(2) S promotes ubiquitin-mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S-sulfhydration.
Zhang S, Wang M, Li H, Li Q, Liu N, Dong S, Zhao Y, Pang K, Huang J, Ren C, Wang Y, Tian Z, Lu F, Zhang W
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2719-2732
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2719-2732
Stimulator of interferon genes promotes diabetic sarcopenia by targeting peroxisome proliferator activated receptors γ degradation and inhibiting fatty acid oxidation.
Yan SB, Liang H, Zhan P, Zheng H, Zhao QX, Zheng ZJ, Lu HX, Shang GK, Ji XP
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2623-2641
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2623-2641
CoCl(2) -triggered pseudohypoxic stress induces proteasomal degradation of SIRT4 via polyubiquitination of lysines K78 and K299.
Hampel N, Georgy J, Mehrabipour M, Lang A, Lehmkuhl I, Scheller J, Ahmadian MR, Floss DM, Piekorz RP
FEBS open bio 2023 Dec;13(12):2187-2199
FEBS open bio 2023 Dec;13(12):2187-2199
RNF125, transcriptionally regulated by NFATC2, alleviates osteoarthritis via inhibiting the Wnt/β-catenin signaling pathway through degrading TRIM14.
Lv R, Du L, Bai L
International immunopharmacology 2023 Dec;125(Pt B):111191
International immunopharmacology 2023 Dec;125(Pt B):111191
Sesamol serves as a p53 stabilizer to relieve rheumatoid arthritis progression and inhibits the growth of synovial organoids.
Lin X, Lin T, Wang X, He J, Gao X, Lyu S, Wang Q, Chen J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155109
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155109
VAMP8 suppresses the metastasis via DDX5/β-catenin signal pathway in osteosarcoma.
Yang S, Zhou P, Zhang L, Xie X, Zhang Y, Bo K, Xue J, Zhang W, Liao F, Xu P, Hu Y, Yan R, Liu D, Chang J, Zhou K
Cancer biology & therapy 2023 Dec 31;24(1):2230641
Cancer biology & therapy 2023 Dec 31;24(1):2230641
E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC.
Tang F, Lu C, He X, Lin W, Xie B, Gao X, Peng Y, Yang D, Sun L, Weng L
Cell reports 2023 Dec 26;42(12):113477
Cell reports 2023 Dec 26;42(12):113477
Salvianolic acid B ameliorates myocardial fibrosis in diabetic cardiomyopathy by deubiquitinating Smad7.
Luo H, Fu L, Wang X, Yini Xu, Ling Tao, Shen X
Chinese medicine 2023 Dec 10;18(1):161
Chinese medicine 2023 Dec 10;18(1):161
circRPS19 affects HK2‑mediated aerobic glycolysis and cell viability via the miR‑125a‑5p/USP7 pathway in gastric cancer.
Zheng X, Shao J, Qian J, Liu S
International journal of oncology 2023 Aug;63(2)
International journal of oncology 2023 Aug;63(2)
The ubiquitin-specific protease 5 mediated deubiquitination of LSH links metabolic regulation of ferroptosis to hepatocellular carcinoma progression.
Yan B, Guo J, Wang Z, Ning J, Wang H, Shu L, Hu K, Chen L, Shi Y, Zhang L, Liu S, Tao Y, Xiao D
MedComm 2023 Aug;4(4):e337
MedComm 2023 Aug;4(4):e337
Wnt/β-Catenin Promotes the Osteoblastic Potential of BMP9 Through Down-Regulating Cyp26b1 in Mesenchymal Stem Cells.
Yao XT, Li PP, Liu J, Yang YY, Luo ZL, Jiang HT, He WG, Luo HH, Deng YX, He BC
Tissue engineering and regenerative medicine 2023 Aug;20(5):705-723
Tissue engineering and regenerative medicine 2023 Aug;20(5):705-723
O-GlcNAcylation enhances Reticulon 2 protein stability and its promotive effects on gastric cancer progression.
Wang G, Xu Z, Sun J, Liu B, Ruan Y, Gu J, Song S
Cellular signalling 2023 Aug;108:110718
Cellular signalling 2023 Aug;108:110718
IRF5 promotes glycolysis in the progression of hepatocellular carcinoma and is regulated by TRIM35.
Fang Y, Lu ZH, Liu BZ, Li N, Yang MZ, Wang P
Journal of digestive diseases 2023 Aug-Sep;24(8-9):480-490
Journal of digestive diseases 2023 Aug-Sep;24(8-9):480-490
Liquiritigenin Confers Liver Protection by Enhancing NRF2 Signaling through Both Canonical and Non-canonical Signaling Pathways.
Shi M, Zhang J, Li M, Zhao Y, Guo Y, Xu J, Liu R, Li Z, Ren D, Liu P
Journal of medicinal chemistry 2023 Aug 24;66(16):11324-11334
Journal of medicinal chemistry 2023 Aug 24;66(16):11324-11334
BDE209-promoted Dio2 degradation in H4 glioma cells through the autophagy pathway, resulting in hypothyroidism and leading to neurotoxicity.
Liu M, Yu Z, Yang F, Zhao Z, Zhou M, Wang C, Zhang B, Liang G, Liu X, Shao J
Toxicology 2023 Aug 1;494:153581
Toxicology 2023 Aug 1;494:153581
Persistent activation of Nrf2 in a p62-dependent non-canonical manner aggravates lead-induced kidney injury by promoting apoptosis and inhibiting autophagy.
Lian CY, Chu BX, Xia WH, Wang ZY, Fan RF, Wang L
Journal of advanced research 2023 Apr;46:87-100
Journal of advanced research 2023 Apr;46:87-100
E3 ligase MAEA-mediated ubiquitination and degradation of PHD3 promotes glioblastoma progression.
Zhou P, Peng X, Tang S, Zhang K, Tan Z, Li D, Shen L, Peng J, Yang L
Oncogene 2023 Apr;42(16):1308-1320
Oncogene 2023 Apr;42(16):1308-1320
CEBPB upregulates P4HA2 to promote the malignant biological behavior in IDH1 wildtype glioma.
Wang S, Wu J, Zhao W, Li M, Li S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Apr;37(4):e22848
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Apr;37(4):e22848
Bone-targeted bortezomib increases bone formation within Calvarial trans-sutural distraction osteogenesis.
Chen H, Cai G, Ruan X, Lu Y, Li G, Chen Z, Guan Z, Zhang H, Sun W, Wang H
Bone 2023 Apr;169:116677
Bone 2023 Apr;169:116677
Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells.
Li J, Sun Y, Zhao X, Ma Y, Xie Y, Liu S, Hui B, Shi X, Sun X, Zhang X
Cell death & disease 2023 Apr 8;14(4):259
Cell death & disease 2023 Apr 8;14(4):259
SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions.
Zhou H, Feng W, Yu J, Shafiq TA, Paulo JA, Zhang J, Luo Z, Gygi SP, Moazed D
Cell reports 2023 Apr 25;42(4):112339
Cell reports 2023 Apr 25;42(4):112339
Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS.
Lyu H, Sun L, Guan Z, Li J, Yin C, Zhang Y, Jiang H
Cell reports 2023 Apr 25;42(4):112309
Cell reports 2023 Apr 25;42(4):112309
Antitumoral effects of Bortezomib in malignant mesothelioma: evidence of mild endoplasmic reticulum stress in vitro and activation of T cell response in vivo.
Benvenuto M, Angiolini V, Focaccetti C, Nardozi D, Palumbo C, Carrano R, Rufini A, Bei R, Miele MT, Mancini P, Barillari G, Cirone M, Ferretti E, Tundo GR, Mutti L, Masuelli L, Bei R
Biology direct 2023 Apr 17;18(1):17
Biology direct 2023 Apr 17;18(1):17
IKZF1 selectively enhances homologous recombination repair by interacting with CtIP and USP7 in multiple myeloma.
Liu M, Zhang Y, Wu Y, Jin J, Cao Y, Fang Z, Geng L, Yang L, Yu M, Bu Z, Ji Y, Shan H, Zou Z, Liu L, Wang Y, Zhang Y, Tong Y, Xu H, Lei H, Liu W, Gao F, Wu Y
International journal of biological sciences 2022;18(6):2515-2526
International journal of biological sciences 2022;18(6):2515-2526
Pantothenate Kinase 1 Inhibits the Progression of Hepatocellular Carcinoma by Negatively Regulating Wnt/β-catenin Signaling.
Zi Y, Gao J, Wang C, Guan Y, Li L, Ren X, Zhu L, Mu Y, Chen SH, Zeng Z, Cao Z, Rong Z, Chen P, Zhang X, Chen T, Xin H, Li X, Li Z, Sun L, Deng Y, Li N, Nie Y
International journal of biological sciences 2022;18(4):1539-1554
International journal of biological sciences 2022;18(4):1539-1554
The lncRNA BDNF-AS/WDR5/FBXW7 axis mediates ferroptosis in gastric cancer peritoneal metastasis by regulating VDAC3 ubiquitination.
Huang G, Xiang Z, Wu H, He Q, Dou R, Lin Z, Yang C, Huang S, Song J, Di Z, Wang S, Xiong B
International journal of biological sciences 2022;18(4):1415-1433
International journal of biological sciences 2022;18(4):1415-1433
Deacetylation of Glutaminase by HDAC4 contributes to Lung Cancer Tumorigenesis.
Wang T, Lu Z, Han T, Wang Y, Gan M, Wang JB
International journal of biological sciences 2022;18(11):4452-4465
International journal of biological sciences 2022;18(11):4452-4465
PPDPF Promotes the Progression and acts as an Antiapoptotic Protein in Non-Small Cell Lung Cancer.
Yun M, Yingzi L, Jie G, Guanxin L, Zimei Z, Zhen C, Zhi L, Yingjie N, Lunquan S, Tao C, Yuezhen D, Chengzhi Z
International journal of biological sciences 2022;18(1):214-228
International journal of biological sciences 2022;18(1):214-228
CHIP Decline Is Associated With Isoflurane-Induced Neurodegeneration in Aged Mice.
Xu Q, Xiong J, Xu L, Wu Y, Li M, Li Q, Jiang T, Luo A, Zhang Y
Frontiers in neuroscience 2022;16:824871
Frontiers in neuroscience 2022;16:824871
Nedd4-2 Haploinsufficiency in Mice Impairs the Ubiquitination of Rer1 and Increases the Susceptibility to Endoplasmic Reticulum Stress and Seizures.
Liu X, Zhang L, Zhang H, Liang X, Zhang B, Tu J, Zhao Y
Frontiers in molecular neuroscience 2022;15:919718
Frontiers in molecular neuroscience 2022;15:919718
Paeoniflorin directly binds to TNFR1 to regulate podocyte necroptosis in diabetic kidney disease.
Wang X, Liu XQ, Jiang L, Huang YB, Zeng HX, Zhu QJ, Qi XM, Wu YG
Frontiers in pharmacology 2022;13:966645
Frontiers in pharmacology 2022;13:966645
Honokiol Inhibits HIF-1α-Mediated Glycolysis to Halt Breast Cancer Growth.
Yi X, Qi M, Huang M, Zhou S, Xiong J
Frontiers in pharmacology 2022;13:796763
Frontiers in pharmacology 2022;13:796763
Dual Effects: Intrastriatal Injection of α-syn N103/tau N368 Preformed Fibrils Promotes Endogenous α-synuclein Aggregates in the Proximal Colon.
Wang J, Yang X, Zeng W, Zhang X, Yang X, Xu Y, Liu K, Zhang Z, Xu Y, Cao X
Journal of Parkinson's disease 2022;12(7):2097-2116
Journal of Parkinson's disease 2022;12(7):2097-2116
Hepatic RACK1 deficiency protects against fulminant hepatitis through myeloid-derived suppressor cells.
Liu G, Wang Q, Deng L, Huang X, Yang G, Cheng Q, Guo T, Guo L, Niu C, Yang X, Dong J, Zhang J
Theranostics 2022;12(5):2248-2265
Theranostics 2022;12(5):2248-2265
Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation.
Li R, Li X, Zhao J, Meng F, Yao C, Bao E, Sun N, Chen X, Cheng W, Hua H, Li X, Wang B, Wang H, Pan X, You H, Yang J, Ikezoe T
Theranostics 2022;12(2):976-998
Theranostics 2022;12(2):976-998
Ring finger protein 128 promotes, rather than inhibits, colorectal cancer progression by regulating the Hippo signaling pathway.
Ning S, Chen Y, Wang G, Liu Y, Yang Y, Zhang Z
Frontiers in oncology 2022;12:1031160
Frontiers in oncology 2022;12:1031160
Tubuloside B, isolated from Cistanche tubulosa, a promising agent against M1 macrophage activation via synergistically targeting Mob1 and ERK1/2.
Xiao L, Yao J, Miao Y, Ou B, Wang J, Huang Y, Zhou B, Ge L, Tian J, Zeng X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113414
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113414
The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells by encoding a novel protein NTRK2-243aa.
Zhao Y, Song J, Dong W, Liu X, Yang C, Wang D, Xue Y, Ruan X, Liu L, Wang P, Zhang M, Liu Y
Cell death & disease 2022 Sep 5;13(9):767
Cell death & disease 2022 Sep 5;13(9):767
LINC01194 recruits NUMA1 to promote ubiquitination of RYR2 to enhance malignant progression in triple-negative breast cancer.
Zhai D, Zhang M, Li Y, Bi J, Kuang X, Shan Z, Shao N, Lin Y
Cancer letters 2022 Sep 28;544:215797
Cancer letters 2022 Sep 28;544:215797
Capsaicin ameliorates diabetic retinopathy by inhibiting poldip2-induced oxidative stress.
Liu K, Gao X, Hu C, Gui Y, Gui S, Ni Q, Tao L, Jiang Z
Redox biology 2022 Oct;56:102460
Redox biology 2022 Oct;56:102460
Dihydroartemisinin suppresses renal fibrosis in mice by inhibiting DNA-methyltransferase 1 and increasing Klotho.
Zhou W, Chen MM, Liu HL, Si ZL, Wu WH, Jiang H, Wang LX, Vaziri ND, An XF, Su K, Chen C, Tan NH, Zhang ZH
Acta pharmacologica Sinica 2022 Oct;43(10):2609-2623
Acta pharmacologica Sinica 2022 Oct;43(10):2609-2623
Linear ubiquitination of PTEN impairs its function to promote prostate cancer progression.
Guo Y, He J, Zhang H, Chen R, Li L, Liu X, Huang C, Qiang Z, Zhou Z, Wang Y, Huang J, Zhao X, Zheng J, Chen GQ, Yu J
Oncogene 2022 Oct;41(44):4877-4892
Oncogene 2022 Oct;41(44):4877-4892
Bortezomib prodrug catalytic nanoreactor for chemo/chemodynamic therapy and macrophage re-education.
Huang Y, Guan Z, Ren L, Luo Y, Chen M, Sun Y, He Y, Zeng Z, Dai X, Jiang J, Huang Z, Zhao C
Journal of controlled release : official journal of the Controlled Release Society 2022 Oct;350:332-349
Journal of controlled release : official journal of the Controlled Release Society 2022 Oct;350:332-349
The HN1/HMGB1 axis promotes the proliferation and metastasis of hepatocellular carcinoma and attenuates the chemosensitivity to oxaliplatin.
Wang R, Fu Y, Yao M, Cui X, Zhao Y, Lu X, Li Y, Lin Y, He S
The FEBS journal 2022 Oct;289(20):6400-6419
The FEBS journal 2022 Oct;289(20):6400-6419
Pyrogallol enhances therapeutic effect of human umbilical cord mesenchymal stem cells against LPS-mediated inflammation and lung injury via activation of Nrf2/HO-1 signaling.
Zhang Y, Yang S, Qiu Z, Huang L, Huang L, Liang Y, Liu X, Wang M, Zhou B
Free radical biology & medicine 2022 Oct;191:66-81
Free radical biology & medicine 2022 Oct;191:66-81
The feedback loop of METTL14 and USP38 regulates cell migration, invasion and EMT as well as metastasis in bladder cancer.
Huang J, Zhou W, Hao C, He Q, Tu X
PLoS genetics 2022 Oct;18(10):e1010366
PLoS genetics 2022 Oct;18(10):e1010366
Deletion of Smurf1 attenuates liver steatosis via stabilization of p53.
Lin W, Zhang X, Zhang C, Li L, Zhang J, Xie P, Zhan Y, An W
Laboratory investigation; a journal of technical methods and pathology 2022 Oct;102(10):1075-1087
Laboratory investigation; a journal of technical methods and pathology 2022 Oct;102(10):1075-1087
MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer.
Wen P, Wang H, Li Y, Sui X, Hou Z, Guo X, Xue W, Liu D, Wang Y, Gao J
Cell communication and signaling : CCS 2022 Oct 28;20(1):170
Cell communication and signaling : CCS 2022 Oct 28;20(1):170
ARHGEF3 regulates the stability of ACLY to promote the proliferation of lung cancer.
Zhou F, Ai W, Zhang Y, Hu Q, Gan M, Wang JB, Han T
Cell death & disease 2022 Oct 14;13(10):870
Cell death & disease 2022 Oct 14;13(10):870
CGG repeat expansion in NOTCH2NLC causes mitochondrial dysfunction and progressive neurodegeneration in Drosophila model.
Yu J, Liufu T, Zheng Y, Xu J, Meng L, Zhang W, Yuan Y, Hong D, Charlet-Berguerand N, Wang Z, Deng J
Proceedings of the National Academy of Sciences of the United States of America 2022 Oct 11;119(41):e2208649119
Proceedings of the National Academy of Sciences of the United States of America 2022 Oct 11;119(41):e2208649119
Capsaicin suppresses hepatocarcinogenesis by inhibiting the stemness of hepatic progenitor cells via SIRT1/SOX2 signaling pathway.
Xie ZQ, Li HX, Hou XJ, Huang MY, Zhu ZM, Wei LX, Tang CX
Cancer medicine 2022 Nov;11(22):4283-4296
Cancer medicine 2022 Nov;11(22):4283-4296
Identification of circular RNA BTBD7_hsa_circ_0000563 as a novel biomarker for coronary artery disease and the functional discovery of BTBD7_hsa_circ_0000563 based on peripheral blood mononuclear cells: a case control study.
Zhou H, Gan X, He S, Wang Y, Zhang S, Chen J, Zhou Y, Hou C, Hua L, Zhang Q, Jia E
Clinical proteomics 2022 Nov 3;19(1):37
Clinical proteomics 2022 Nov 3;19(1):37
14-3-3 proteins contribute to autophagy by modulating SINAT-mediated degradation of ATG13.
Qi H, Lei X, Wang Y, Yu S, Liu T, Zhou SK, Chen JY, Chen QF, Qiu RL, Jiang L, Xiao S
The Plant cell 2022 Nov 29;34(12):4857-4876
The Plant cell 2022 Nov 29;34(12):4857-4876
Hydrogen Sulfide Regulates SERCA2a Ubiquitylation via Muscle RING Finger-1 S-Sulfhydration to Affect Cardiac Contractility in db/db Mice.
Peng S, Zhao D, Li Q, Wang M, Zhang S, Pang K, Huang J, Lu F, Chen H, Zhang W
Cells 2022 Nov 2;11(21)
Cells 2022 Nov 2;11(21)
Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis.
Ling X, Lu J, Wang X, Liu L, Liu L, Wang Y, Sun Y, Ren C, Lu C, Yu Z
iScience 2022 Nov 18;25(11):105363
iScience 2022 Nov 18;25(11):105363
Ubiquitination regulates cytoophidium assembly in Schizosaccharomyces pombe.
Andreadis C, Li T, Liu JL
Experimental cell research 2022 Nov 1;420(1):113337
Experimental cell research 2022 Nov 1;420(1):113337
UBE2L3 promotes squamous cell carcinoma progression in the oral cavity and hypopharynx via activating the NF-κB signaling by increasing IκBα degradation.
Cui Z, Sun S, Li J, Li J, Sha T, He J, Zuo L
Cell biology international 2022 May;46(5):806-818
Cell biology international 2022 May;46(5):806-818
Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension.
Xiang G, Ying K, Jiang P, Jia M, Sun Y, Li S, Wu X, Hao S
Skeletal muscle 2022 May 6;12(1):10
Skeletal muscle 2022 May 6;12(1):10
CCDC50 suppresses NLRP3 inflammasome activity by mediating autophagic degradation of NLRP3.
Lin Y, Li Z, Wang Y, Tian T, Jia P, Ye Y, He M, Yang Z, Li C, Guo D, Hou P
EMBO reports 2022 May 4;23(5):e54453
EMBO reports 2022 May 4;23(5):e54453
Rho family GTPase 1 (RND1), a novel regulator of p53, enhances ferroptosis in glioblastoma.
Sun Q, Xu Y, Yuan F, Qi Y, Wang Y, Chen Q, Liu B
Cell & bioscience 2022 May 3;12(1):53
Cell & bioscience 2022 May 3;12(1):53
Gamma frequency light flicker regulates amyloid precursor protein trafficking for reducing β-amyloid load in Alzheimer's disease model.
Shen Q, Wu X, Zhang Z, Zhang D, Yang S, Xing D
Aging cell 2022 Mar;21(3):e13573
Aging cell 2022 Mar;21(3):e13573
A novel protein encoded by circHNRNPU promotes multiple myeloma progression by regulating the bone marrow microenvironment and alternative splicing.
Tang X, Deng Z, Ding P, Qiang W, Lu Y, Gao S, Hu Y, Yang Y, Du J, Gu C
Journal of experimental & clinical cancer research : CR 2022 Mar 8;41(1):85
Journal of experimental & clinical cancer research : CR 2022 Mar 8;41(1):85
Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide.
Song H, Wang C, Zhu C, Wang Z, Yang H, Wu P, Cui X, Botas J, Dang Y, Ding Y, Fei Y, Lu B
Proceedings of the National Academy of Sciences of the United States of America 2022 Mar 8;119(10):e2114303119
Proceedings of the National Academy of Sciences of the United States of America 2022 Mar 8;119(10):e2114303119
Inhibition of USP7 suppresses advanced glycation end-induced cell cycle arrest and senescence of human umbilical vein endothelial cells through ubiquitination of p53.
Li X, Wang T, Tao Y, Wang X, Li L, Liu J
Acta biochimica et biophysica Sinica 2022 Mar 25;54(3):311-320
Acta biochimica et biophysica Sinica 2022 Mar 25;54(3):311-320
lncRNA SNHG26 promoted the growth, metastasis, and cisplatin resistance of tongue squamous cell carcinoma through PGK1/Akt/mTOR signal pathway.
Jiang Q, Wang Z, Qi Q, Li J, Xin Y, Qiu J
Molecular therapy oncolytics 2022 Mar 17;24:355-370
Molecular therapy oncolytics 2022 Mar 17;24:355-370
HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway.
Guo K, Ma Z, Zhang Y, Han L, Shao C, Feng Y, Gao F, Di S, Zhang Z, Zhang J, Tabbò F, Ekman S, Suda K, Cappuzzo F, Han J, Li X, Yan X
Journal of experimental & clinical cancer research : CR 2022 Mar 11;41(1):91
Journal of experimental & clinical cancer research : CR 2022 Mar 11;41(1):91
GSK-3β inhibition elicits a neuroprotection by restoring lysosomal dysfunction in neurons via facilitation of TFEB nuclear translocation after ischemic stroke.
Zhang Y, Wu Z, Huang Z, Liu Y, Chen X, Zhao X, He H, Deng Y
Brain research 2022 Mar 1;1778:147768
Brain research 2022 Mar 1;1778:147768
AAA-ATPase valosin-containing protein binds the transcription factor SREBP1 and promotes its proteolytic activation by rhomboid protease RHBDL4.
Shibuya K, Ebihara K, Ebihara C, Sawayama N, Isoda M, Yamamuro D, Takahashi M, Nagashima S, Ishibashi S
The Journal of biological chemistry 2022 Jun;298(6):101936
The Journal of biological chemistry 2022 Jun;298(6):101936
The role of NOTCH2NLC in Parkinson's disease: A clinical, neuroimaging, and pathological study.
Liu P, Yang D, Zhang F, Chen S, Xie F, Luo Y, Wang H, Chen Y, Lin Z, Wang L, Chen X, Wang B, Wu S, Ouyang Z, Cen Z, Luo W
European journal of neurology 2022 Jun;29(6):1610-1618
European journal of neurology 2022 Jun;29(6):1610-1618
Hsa_circ_0072309 enhances autophagy and TMZ sensitivity in glioblastoma.
Yuan F, Zhang S, Sun Q, Ye L, Xu Y, Xu Z, Deng G, Zhang S, Liu B, Chen Q
CNS neuroscience & therapeutics 2022 Jun;28(6):897-912
CNS neuroscience & therapeutics 2022 Jun;28(6):897-912
Stress-induced epinephrine promotes epithelial-to-mesenchymal transition and stemness of CRC through the CEBPB/TRIM2/P53 axis.
Zhou Z, Shu Y, Bao H, Han S, Liu Z, Zhao N, Yuan W, Jian C, Shu X
Journal of translational medicine 2022 Jun 7;20(1):262
Journal of translational medicine 2022 Jun 7;20(1):262
Mistargeting of aggregation prone mitochondrial proteins activates a nucleus-mediated posttranscriptional quality control pathway in trypanosomes.
Dewar CE, Oeljeklaus S, Mani J, Mühlhäuser WWD, von Känel C, Zimmermann J, Ochsenreiter T, Warscheid B, Schneider A
Nature communications 2022 Jun 2;13(1):3084
Nature communications 2022 Jun 2;13(1):3084
Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death.
Sun Y, Yang YM, Hu YY, Ouyang L, Sun ZH, Yin XF, Li N, He QY, Wang Y
Redox biology 2022 Jul;53:102334
Redox biology 2022 Jul;53:102334
A novel circular RNA confers trastuzumab resistance in human epidermal growth factor receptor 2-positive breast cancer through regulating ferroptosis.
Wang S, Wang Y, Li Q, Li X, Feng X
Environmental toxicology 2022 Jul;37(7):1597-1607
Environmental toxicology 2022 Jul;37(7):1597-1607
Cyclo(-Phe-Phe) alleviates chick embryo liver injury via activating the Nrf2 pathway.
Zhang QY, Han SC, Huang RP, Jiang MY, Yan CY, Li XY, Zhan YJ, Li XM, Li YF, Kurihara H, Tan RR, Li WX, He RR
Food & function 2022 Jul 4;13(13):6962-6974
Food & function 2022 Jul 4;13(13):6962-6974
SNHG25 facilitates SNORA50C accumulation to stabilize HDAC1 in neuroblastoma cells.
Zeng H, Pan J, Hu C, Yang J, Li J, Tan T, Zheng M, Shen Y, Yang T, Deng Y, Zou Y
Cell death & disease 2022 Jul 11;13(7):597
Cell death & disease 2022 Jul 11;13(7):597
Glutathione-responsive copper-disulfiram nanoparticles for enhanced tumor chemotherapy.
Chen M, Huang Z, Xia M, Ding Y, Shan T, Guan Z, Dai X, Xu X, Huang Y, Huang M, Zhao C
Journal of controlled release : official journal of the Controlled Release Society 2022 Jan;341:351-363
Journal of controlled release : official journal of the Controlled Release Society 2022 Jan;341:351-363
RNF2 promotes the progression of colon cancer by regulating ubiquitination and degradation of IRF4.
Wang J, Ouyang X, Zhou Z, Mao S, Niu X, Li H, Xu W, Song Y, Cao J, Lai B
Biochimica et biophysica acta. Molecular cell research 2022 Jan;1869(1):119162
Biochimica et biophysica acta. Molecular cell research 2022 Jan;1869(1):119162
Choline-induced SLC5A7 impairs colorectal cancer growth by stabilizing p53 protein.
Yin Y, Jiang Z, Fu J, Li Y, Fang C, Yin X, Chen Y, Chen N, Li J, Ji Y, Su X, Qiu M, Huang W, Zhang B, Deng H, Dai L
Cancer letters 2022 Jan 28;525:55-66
Cancer letters 2022 Jan 28;525:55-66
MF-094, a potent and selective USP30 inhibitor, accelerates diabetic wound healing by inhibiting the NLRP3 inflammasome.
Li X, Wang T, Tao Y, Wang X, Li L, Liu J
Experimental cell research 2022 Jan 15;410(2):112967
Experimental cell research 2022 Jan 15;410(2):112967
Phosphorylation-Induced Ubiquitination and Degradation of PXR through CDK2-TRIM21 Axis.
Qin M, Xin Y, Bian Y, Yang X, Xi T, Xiong J
Cells 2022 Jan 13;11(2)
Cells 2022 Jan 13;11(2)
Hemin enhances radiosensitivity of lung cancer cells through ferroptosis.
Almahi WA, Yu KN, Mohammed F, Kong P, Han W
Experimental cell research 2022 Jan 1;410(1):112946
Experimental cell research 2022 Jan 1;410(1):112946
SPOCK1 promotes metastasis in pancreatic cancer via NF-κB-dependent epithelial-mesenchymal transition by interacting with IκB-α.
Cui X, Wang Y, Lan W, Wang S, Cui Y, Zhang X, Lin Z, Piao J
Cellular oncology (Dordrecht, Netherlands) 2022 Feb;45(1):69-84
Cellular oncology (Dordrecht, Netherlands) 2022 Feb;45(1):69-84
RNF6 promotes the migration and invasion of breast cancer by promoting the ubiquitination and degradation of MST1.
Huang Y, Zou Y, Jie Z
Experimental and therapeutic medicine 2022 Feb;23(2):118
Experimental and therapeutic medicine 2022 Feb;23(2):118
Ubiquitinated gasdermin D mediates arsenic-induced pyroptosis and hepatic insulin resistance in rat liver.
Zhu Y, Zhang J, Yao X, Qiu T, Jiang L, Wang N, Shi Y, Wu C, Yuan W, Yang G, Liu X, Bai J, Men L, Sun X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Feb;160:112771
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Feb;160:112771
Splicing factor arginine/serine-rich 8 promotes multiple myeloma malignancy and bone lesion through alternative splicing of CACYBP and exosome-based cellular communication.
Zhang Y, Yu X, Sun R, Min J, Tang X, Lin Z, Xie S, Li X, Lu S, Tian Z, Gu C, Teng L, Yang Y
Clinical and translational medicine 2022 Feb;12(2):e684
Clinical and translational medicine 2022 Feb;12(2):e684
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy.
Sun X, Shu Y, Ye G, Wu C, Xu M, Gao R, Huang D, Zhang J
Acta pharmaceutica Sinica. B 2022 Feb;12(2):838-852
Acta pharmaceutica Sinica. B 2022 Feb;12(2):838-852
The dual role of p62 in ferroptosis of glioblastoma according to p53 status.
Yuan F, Sun Q, Zhang S, Ye L, Xu Y, Deng G, Xu Z, Zhang S, Liu B, Chen Q
Cell & bioscience 2022 Feb 25;12(1):20
Cell & bioscience 2022 Feb 25;12(1):20
Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway.
Chen GH, Song CC, Pantopoulos K, Wei XL, Zheng H, Luo Z
Free radical biology & medicine 2022 Feb 20;180:95-107
Free radical biology & medicine 2022 Feb 20;180:95-107
The deubiquitinating enzyme USP20 regulates the stability of the MCL1 protein.
Feng J, Liu P, Li X, Zhang D, Lin H, Hou Z, Guo C, Niu Y, Dai B, Wang O, Qi M, Wang H, Zhou H
Biochemical and biophysical research communications 2022 Feb 19;593:122-128
Biochemical and biophysical research communications 2022 Feb 19;593:122-128
4EBP1 senses extracellular glucose deprivation and initiates cell death signaling in lung cancer.
Wang Y, Lei J, Zhang S, Wang X, Jin J, Liu Y, Gan M, Yuan Y, Sun L, Li X, Han T, Wang JB
Cell death & disease 2022 Dec 27;13(12):1075
Cell death & disease 2022 Dec 27;13(12):1075
Acetylation of Checkpoint suppressor 1 enhances its stability and promotes the progression of triple-negative breast cancer.
Xu Z, Liu S, Feng C, Xu F, Kong D, Mi J, Yang C, Zhang G, Wei P, Orgil BO, Bergquist J, Tian G
Cell death discovery 2022 Dec 1;8(1):474
Cell death discovery 2022 Dec 1;8(1):474
The SPATA2/CYLD pathway contributes to doxorubicin-induced cardiomyocyte ferroptosis via enhancing ferritinophagy.
Zhou YJ, Duan DQ, Lu LQ, Tang LJ, Zhang XJ, Luo XJ, Peng J
Chemico-biological interactions 2022 Dec 1;368:110205
Chemico-biological interactions 2022 Dec 1;368:110205
The daily caloric restriction and alternate-day fasting ameliorated lipid dysregulation in type 2 diabetic mice by downregulating hepatic pescadillo 1.
Zhou J, Jiang Z, Lin Y, Li C, Liu J, Tian M, Liu Y, Chen K
European journal of nutrition 2022 Aug;61(5):2775-2797
European journal of nutrition 2022 Aug;61(5):2775-2797
E3 ubiquitin ligase NEURL3 promotes innate antiviral response through catalyzing K63-linked ubiquitination of IRF7.
Qi F, Zhang X, Wang L, Ren C, Zhao X, Luo J, Lu D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Aug;36(8):e22409
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Aug;36(8):e22409
Melatonin inhibits angiotensin II-induced atrial fibrillation through preventing degradation of Ang II Type I Receptor-Associated Protein (ATRAP).
Xie X, Shen TT, Bi HL, Su ZL, Liao ZQ, Zhang Y, Shi L, Xia YL
Biochemical pharmacology 2022 Aug;202:115146
Biochemical pharmacology 2022 Aug;202:115146
Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation.
Li X, Zhang Y, Zhao Y, Zhou Y, Han Q, Yang Y, Zhang L, Shi L, Jin X, Zhang R, Gao H, Xue G, Li D, Zhang ZR, Lu Y, Yang B, Pan Z
Pharmacological research 2022 Aug;182:106284
Pharmacological research 2022 Aug;182:106284
Pharmacological induction of AMFR increases functional EAAT2 oligomer levels and reduces epileptic seizures in mice.
Sha L, Li G, Zhang X, Lin Y, Qiu Y, Deng Y, Zhu W, Xu Q
JCI insight 2022 Aug 8;7(15)
JCI insight 2022 Aug 8;7(15)
GNIP1 functions both as a scaffold protein and an E3 ubiquitin ligase to regulate autophagy in lung cancer.
Zhou F, Liu Y, Ai W, Wang Y, Gan M, Jiang Q, Han T, Wang JB
Cell communication and signaling : CCS 2022 Aug 30;20(1):133
Cell communication and signaling : CCS 2022 Aug 30;20(1):133
PGE(2) -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.
Tao X, Du R, Guo S, Feng X, Yu T, OuYang Q, Chen Q, Fan X, Wang X, Guo C, Li X, Xue F, Chen S, Tong M, Lazarus M, Zuo S, Yu Y, Shen Y
The EMBO journal 2022 Aug 16;41(16):e110439
The EMBO journal 2022 Aug 16;41(16):e110439
CRIP1 suppresses BBOX1-mediated carnitine metabolism to promote stemness in hepatocellular carcinoma.
Wang J, Zhou Y, Zhang D, Zhao W, Lu Y, Liu C, Lin W, Zhang Y, Chen K, Wang H, Zhao L
The EMBO journal 2022 Aug 1;41(15):e110218
The EMBO journal 2022 Aug 1;41(15):e110218
A small molecule inhibitor of caspase-1 inhibits NLRP3 inflammasome activation and pyroptosis to alleviate gouty inflammation.
Cao DY, Zhang ZH, Li RZ, Shi XK, Xi RY, Zhang GL, Li F, Wang F
Immunology letters 2022 Apr;244:28-39
Immunology letters 2022 Apr;244:28-39
UBE4B promotes the development of lung adenocarcinoma by enhancing proliferation, migration and glycolysis via PP2A/AKT signaling.
Wu S, Xie L, Cheng S, Fan Z, Sang H, Li Q
Pathology, research and practice 2022 Apr;232:153762
Pathology, research and practice 2022 Apr;232:153762
Circular RNA MTCL1 promotes advanced laryngeal squamous cell carcinoma progression by inhibiting C1QBP ubiquitin degradation and mediating beta-catenin activation.
Wang Z, Sun A, Yan A, Yao J, Huang H, Gao Z, Han T, Gu J, Li N, Wu H, Li K
Molecular cancer 2022 Apr 2;21(1):92
Molecular cancer 2022 Apr 2;21(1):92
circFAM120B functions as a tumor suppressor in esophageal squamous cell carcinoma via the miR-661/PPM1L axis and the PKR/p38 MAPK/EMT pathway.
Song H, Tian D, Sun J, Mao X, Kong W, Xu D, Ji Y, Qiu B, Zhan M, Wang J
Cell death & disease 2022 Apr 18;13(4):361
Cell death & disease 2022 Apr 18;13(4):361
Proteasome 26S subunit, non-ATPase 1 (PSMD1) facilitated the progression of lung adenocarcinoma by the de-ubiquitination and stability of PTEN-induced kinase 1 (PINK1).
Liu L, Liu A, Dong J, Zuo Z, Liu X
Experimental cell research 2022 Apr 15;413(2):113075
Experimental cell research 2022 Apr 15;413(2):113075
Golgi Phosphoprotein 3 Confers Radioresistance via Stabilizing EGFR in Lung Adenocarcinoma.
Chen G, Kong P, Yang M, Hu W, Prise KM, Yu KN, Cui S, Qin F, Meng G, Almahi WA, Nie L, Han W
International journal of radiation oncology, biology, physics 2022 Apr 1;112(5):1216-1228
International journal of radiation oncology, biology, physics 2022 Apr 1;112(5):1216-1228
Nuclear Receptor Interacting Protein-2 Mediates the Stabilization and Activation of β-Catenin During Podocyte Injury.
Hou Q, Le W, Kan S, Shi J, Lang Y, Liu Z, Chen Z
Frontiers in cell and developmental biology 2021;9:781792
Frontiers in cell and developmental biology 2021;9:781792
Autophagy Regulates VDAC3 Ubiquitination by FBXW7 to Promote Erastin-Induced Ferroptosis in Acute Lymphoblastic Leukemia.
Zhu T, Liu B, Wu D, Xu G, Fan Y
Frontiers in cell and developmental biology 2021;9:740884
Frontiers in cell and developmental biology 2021;9:740884
ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells.
Yang Y, Li C, Gu X, Zhen J, Zhu S, Lv T, Wan Q, Liu Y
Frontiers in cell and developmental biology 2021;9:700195
Frontiers in cell and developmental biology 2021;9:700195
UBC Mediated by SEPT6 Inhibited the Progression of Prostate Cancer.
Zhang R, Yang Y, Huang H, Li T, Ye L, Lin L, Wei Y
Mediators of inflammation 2021;2021:7393029
Mediators of inflammation 2021;2021:7393029
Simultaneous silencing Aurora-A and UHRF1 inhibits colorectal cancer cell growth through regulating expression of DNMT1 and STAT1.
Han J, Chen X, Xu J, Chu L, Li R, Sun N, Jiang Z, Liu H, Ge X, Zheng J, Yang J, Ikezoe T
International journal of medical sciences 2021;18(15):3437-3451
International journal of medical sciences 2021;18(15):3437-3451
MAD2B-mediated cell cycle reentry of podocytes is involved in the pathogenesis of FSGS.
Bao D, Su H, Lei CT, Tang H, Ye C, Xiong W, He FF, Lin JH, Hammes HP, Zhang C
International journal of biological sciences 2021;17(15):4396-4408
International journal of biological sciences 2021;17(15):4396-4408
Pentamidine Inhibits Ovarian Cancer Cell Proliferation and Migration by Maintaining Stability of PTEN in vitro.
Wu Y, Zhang Z, Kou Z
Drug design, development and therapy 2021;15:2857-2868
Drug design, development and therapy 2021;15:2857-2868
Deltex3 inhibits Epithelial Mesenchymal Transition in Papillary Thyroid Carcinoma via promoting ubiquitination of XRCC5 to regulate the AKT signal pathway.
Wang L, Huang Y, Liu C, Guo M, Ma Z, He J, Wang A, Sun X, Liu Z
Journal of Cancer 2021;12(3):860-873
Journal of Cancer 2021;12(3):860-873
Nogo-B receptor is required for stabilizing TGF-β type I receptor and promotes the TGF-β1-induced epithelial-to-mesenchymal transition of non-small cell lung cancer.
Wu D, Zhao B, Song Y, Chi X, Fu H, Guan T, Zhang L, Yang X, Hu K, Huang R, Jin X, Miao QR, Shao S
Journal of Cancer 2021;12(3):717-725
Journal of Cancer 2021;12(3):717-725
Tetrandrine Modulates Rheb-mTOR Signaling-Mediated Selective Autophagy and Protects Pulmonary Fibrosis.
Liu Y, Zhong W, Zhang J, Chen W, Lu Y, Qiao Y, Zeng Z, Huang H, Cai S, Dong H
Frontiers in pharmacology 2021;12:739220
Frontiers in pharmacology 2021;12:739220
Samotolisib Attenuates Acute Liver Injury Through Inhibiting Caspase-11-Mediated Pyroptosis Via Regulating E3 Ubiquitin Ligase Nedd4.
Zhao YY, Wu DM, He M, Zhang F, Zhang T, Liu T, Li J, Li L, Xu Y
Frontiers in pharmacology 2021;12:726198
Frontiers in pharmacology 2021;12:726198
Autophagic Inhibition of Caveolin-1 by Compound Phyllanthus urinaria L. Activates Ubiquitination and Proteasome Degradation of β-catenin to Suppress Metastasis of Hepatitis B-Associated Hepatocellular Carcinoma.
Huang D, Yang B, Yao Y, Liao M, Zhang Y, Zeng Y, Zhang F, Wang N, Tong G
Frontiers in pharmacology 2021;12:659325
Frontiers in pharmacology 2021;12:659325
Hepatitis B Surface Antigen Suppresses the Activation of Nuclear Factor Kappa B Pathway via Interaction With the TAK1-TAB2 Complex.
Deng F, Xu G, Cheng Z, Huang Y, Ma C, Luo C, Yu C, Wang J, Xu X, Liu S, Zhu Y
Frontiers in immunology 2021;12:618196
Frontiers in immunology 2021;12:618196
YY1-mediated reticulocalbin-2 upregulation promotes the hepatocellular carcinoma progression via activating MYC signaling.
Mei C, Jiang X, Gu Y, Wu X, Ma W, Chen X, Wang G, Yao Y, Liu Y, Zhang Z, Yuan Y
American journal of cancer research 2021;11(5):2238-2251
American journal of cancer research 2021;11(5):2238-2251
TRIM50 Suppresses Pancreatic Cancer Progression and Reverses the Epithelial-Mesenchymal Transition via Facilitating the Ubiquitous Degradation of Snail1.
Li R, Zhu L, Peng Y, Zhang X, Dai C, Liu D
Frontiers in oncology 2021;11:695740
Frontiers in oncology 2021;11:695740
CDC20 promotes bone formation via APC/C dependent ubiquitination and degradation of p65.
Du Y, Zhang M, Liu X, Li Z, Hu M, Tian Y, Lv L, Zhang X, Liu Y, Zhang P, Zhou Y
EMBO reports 2021 Sep 6;22(9):e52576
EMBO reports 2021 Sep 6;22(9):e52576
Proteasome inhibition by bortezomib parallels a reduction in head and neck cancer cells growth, and an increase in tumor-infiltrating immune cells.
Benvenuto M, Ciuffa S, Focaccetti C, Sbardella D, Fazi S, Scimeca M, Tundo GR, Barillari G, Segni M, Bonanno E, Manzari V, Modesti A, Masuelli L, Coletta M, Bei R
Scientific reports 2021 Sep 24;11(1):19051
Scientific reports 2021 Sep 24;11(1):19051
Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex.
Li XJ, Zhang YY, Fu YH, Zhang H, Li HX, Li QF, Li HL, Tan RK, Jiang CX, Jiang W, Li ZX, Luo C, Lu BX, Dang YJ
Acta pharmacologica Sinica 2021 Oct;42(10):1556-1566
Acta pharmacologica Sinica 2021 Oct;42(10):1556-1566
Hydrogen sulphide reduced the accumulation of lipid droplets in cardiac tissues of db/db mice via Hrd1 S-sulfhydration.
Sun Y, Zhang L, Lu B, Wen J, Wang M, Zhang S, Li Q, Shu F, Lu F, Liu N, Peng S, Zhao Y, Dong S, Lu F, Zhang W, Wang Y
Journal of cellular and molecular medicine 2021 Oct;25(19):9154-9167
Journal of cellular and molecular medicine 2021 Oct;25(19):9154-9167
Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy: Dynamic analysis on cytotoxic effects of LW-218.
Hu P, Li H, Sun W, Wang H, Yu X, Qing Y, Wang Z, Zhu M, Xu J, Guo Q, Hui H
Acta pharmaceutica Sinica. B 2021 Oct;11(10):3178-3192
Acta pharmaceutica Sinica. B 2021 Oct;11(10):3178-3192
Melatonin potentiates the cytotoxic effect of Neratinib in HER2(+) breast cancer through promoting endocytosis and lysosomal degradation of HER2.
Liu Z, Sang X, Wang M, Liu Y, Liu J, Wang X, Liu P, Cheng H
Oncogene 2021 Nov;40(44):6273-6283
Oncogene 2021 Nov;40(44):6273-6283
NudCL2 is an autophagy receptor that mediates selective autophagic degradation of CP110 at mother centrioles to promote ciliogenesis.
Liu M, Zhang W, Li M, Feng J, Kuang W, Chen X, Yang F, Sun Q, Xu Z, Hua J, Yang C, Liu W, Shu Q, Yang Y, Zhou T, Xie S
Cell research 2021 Nov;31(11):1199-1211
Cell research 2021 Nov;31(11):1199-1211
DOC-2/DAB2 interactive protein destabilizes c-Myc to impair the growth and self-renewal of colon tumor-repopulating cells.
Li H, Zhou Y, Wang M, Wang H, Zhang Y, Peng R, Zhang R, Zhang M, Zhang M, Qiu P, Liu L, Zhao Q, Liu J
Cancer science 2021 Nov;112(11):4593-4603
Cancer science 2021 Nov;112(11):4593-4603
Efficacy and long-term safety of CRISPR/Cas9 genome editing in the SOD1-linked mouse models of ALS.
Deng HX, Zhai H, Shi Y, Liu G, Lowry J, Liu B, Ryan ÉB, Yan J, Yang Y, Zhang N, Yang Z, Liu E, Ma YC, Siddique T
Communications biology 2021 Mar 25;4(1):396
Communications biology 2021 Mar 25;4(1):396
Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2/ARE axis.
Liu Z, He Q, Liu Y, Zhang Y, Cui M, Peng H, Wang Y, Chen S, Li D, Chen L, Xiao Y, Chen W, Wang Q
Toxicology 2021 Jun 30;458:152838
Toxicology 2021 Jun 30;458:152838
Osteocrin, a novel myokine, prevents diabetic cardiomyopathy via restoring proteasomal activity.
Zhang X, Hu C, Yuan XP, Yuan YP, Song P, Kong CY, Teng T, Hu M, Xu SC, Ma ZG, Tang QZ
Cell death & disease 2021 Jun 16;12(7):624
Cell death & disease 2021 Jun 16;12(7):624
PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53.
Wang W, Wei J, Zhang H, Zheng X, Zhou H, Luo Y, Yang J, Deng Q, Huang S, Fu Z
Cell death & disease 2021 Jun 11;12(6):605
Cell death & disease 2021 Jun 11;12(6):605
Nedd4-2 haploinsufficiency in mice causes increased seizure susceptibility and impaired Kir4.1 ubiquitination.
Liu X, Zhang H, Zhang B, Tu J, Li X, Zhao Y
Biochimica et biophysica acta. Molecular basis of disease 2021 Jun 1;1867(6):166128
Biochimica et biophysica acta. Molecular basis of disease 2021 Jun 1;1867(6):166128
Gankyrin activates the hedgehog signalling to drive metastasis in osteosarcoma.
Wang C, Jing J, Hu X, Yu S, Yao F, Li Z, Cheng L
Journal of cellular and molecular medicine 2021 Jul;25(13):6232-6241
Journal of cellular and molecular medicine 2021 Jul;25(13):6232-6241
USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites.
Chai P, Cheng Y, Hou C, Yin L, Zhang D, Hu Y, Chen Q, Zheng P, Teng J, Chen J
The Journal of cell biology 2021 Jul 5;220(7)
The Journal of cell biology 2021 Jul 5;220(7)
Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/TfR1 pathway in the rat hearts after ischemia/reperfusion.
Tang LJ, Zhou YJ, Xiong XM, Li NS, Zhang JJ, Luo XJ, Peng J
Free radical biology & medicine 2021 Jan;162:339-352
Free radical biology & medicine 2021 Jan;162:339-352
Baicalein suppresses growth of non-small cell lung carcinoma by targeting MAP4K3.
Li J, Yan L, Luo J, Tong L, Gao Y, Feng W, Wang F, Cui W, Li S, Sun Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:110965
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:110965
Polyglucosan body myopathy 1 may cause cognitive impairment: a case report from China.
Chen L, Wang N, Hu W, Yu X, Yang R, Han Y, Yan Y, Nian N, Sha C
BMC musculoskeletal disorders 2021 Jan 7;22(1):35
BMC musculoskeletal disorders 2021 Jan 7;22(1):35
Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice.
Ding X, Xiang Z, Qin C, Chen Y, Tian H, Meng L, Xia D, Liu H, Song J, Fu J, Ma M, Wang X
Acta neuropathologica communications 2021 Jan 18;9(1):15
Acta neuropathologica communications 2021 Jan 18;9(1):15
FV-429 induces autophagy blockage and lysosome-dependent cell death of T-cell malignancies via lysosomal dysregulation.
Hu P, Wang J, Qing Y, Li H, Sun W, Yu X, Hui H, Guo Q, Xu J
Cell death & disease 2021 Jan 13;12(1):80
Cell death & disease 2021 Jan 13;12(1):80
Dysregulation of USP18/FTO/PYCR1 signaling network promotes bladder cancer development and progression.
Song W, Yang K, Luo J, Gao Z, Gao Y
Aging 2021 Jan 10;13(3):3909-3925
Aging 2021 Jan 10;13(3):3909-3925
Role of the E3 ubiquitin ligase HRD1 in the regulation of serotonin transporter function.
Taguchi K, Kaneko M, Motoike S, Harada K, Hide I, Tanaka S, Sakai N
Biochemical and biophysical research communications 2021 Jan 1;534:583-589
Biochemical and biophysical research communications 2021 Jan 1;534:583-589
FAT10 promotes the progression of bladder cancer by upregulating HK2 through the EGFR/AKT pathway.
Zou Y, Du Y, Cheng C, Deng X, Shi Z, Lu X, Hu H, Qiu J, Jiang W
Experimental cell research 2021 Jan 1;398(1):112401
Experimental cell research 2021 Jan 1;398(1):112401
SQSTM1/ p62 oligomerization contributes to Aβ-induced inhibition of Nrf2 signaling.
Guo C, Zhang Y, Nie Q, Cao D, Wang X, Wan X, Liu M, Cui J, Sun J, Bai Y, Li L
Neurobiology of aging 2021 Feb;98:10-20
Neurobiology of aging 2021 Feb;98:10-20
The novel ZEB1-upregulated protein PRTG induced by Helicobacter pylori infection promotes gastric carcinogenesis through the cGMP/PKG signaling pathway.
Xiang T, Yuan C, Guo X, Wang H, Cai Q, Xiang Y, Luo W, Liu G
Cell death & disease 2021 Feb 4;12(2):150
Cell death & disease 2021 Feb 4;12(2):150
DUOX2 promotes the progression of colorectal cancer cells by regulating the AKT pathway and interacting with RPL3.
Zhang X, Han J, Feng L, Zhi L, Jiang D, Yu B, Zhang Z, Gao B, Zhang C, Li M, Zhao L, Wang G
Carcinogenesis 2021 Feb 11;42(1):105-117
Carcinogenesis 2021 Feb 11;42(1):105-117
Upstream open reading frame with NOTCH2NLC GGC expansion generates polyglycine aggregates and disrupts nucleocytoplasmic transport: implications for polyglycine diseases.
Zhong S, Lian Y, Luo W, Luo R, Wu X, Ji J, Ji Y, Ding J, Wang X
Acta neuropathologica 2021 Dec;142(6):1003-1023
Acta neuropathologica 2021 Dec;142(6):1003-1023
Hsa_circ_0024093 accelerates VSMC proliferation via miR-4677-3p/miR-889-3p/USP9X/YAP1 axis in in vitro model of lower extremity ASO.
Zhang X, Wang P, Yuan K, Li M, Shen Y, Que H, Wang Y, Liang W
Molecular therapy. Nucleic acids 2021 Dec 3;26:511-522
Molecular therapy. Nucleic acids 2021 Dec 3;26:511-522
CCT8 recovers WTp53-suppressed cell cycle evolution and EMT to promote colorectal cancer progression.
Liao Q, Ren Y, Yang Y, Zhu X, Zhi Y, Zhang Y, Chen Y, Ding Y, Zhao L
Oncogenesis 2021 Dec 3;10(12):84
Oncogenesis 2021 Dec 3;10(12):84
USP3 promotes gastric cancer progression and metastasis by deubiquitination-dependent COL9A3/COL6A5 stabilisation.
Wu X, Wang H, Zhu D, Chai Y, Wang J, Dai W, Xiao Y, Tang W, Li J, Hong L, Pei M, Zhang J, Lin Z, Wang J, Li A, Liu S
Cell death & disease 2021 Dec 20;13(1):10
Cell death & disease 2021 Dec 20;13(1):10
Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling.
Cao P, Yang A, Li P, Xia X, Han Y, Zhou G, Wang R, Yang F, Li Y, Zhang Y, Cui Y, Ji H, Lu L, He F, Zhou G
Science advances 2021 Aug;7(35)
Science advances 2021 Aug;7(35)
Increased AT(1) receptor expression mediates vasoconstriction leading to hypertension in Snx1(-/-) mice.
Liu C, Li X, Fu J, Chen K, Liao Q, Wang J, Chen C, Luo H, Jose PA, Yang Y, Yang J, Zeng C
Hypertension research : official journal of the Japanese Society of Hypertension 2021 Aug;44(8):906-917
Hypertension research : official journal of the Japanese Society of Hypertension 2021 Aug;44(8):906-917
Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage.
Dai C, Wu B, Chen Y, Li X, Bai Y, Du Y, Pang Y, Wang YT, Dong Z
Cell death and differentiation 2021 Aug;28(8):2367-2384
Cell death and differentiation 2021 Aug;28(8):2367-2384
Ubiquitin-dependent Argonauteprotein MEL1 degradation is essential for rice sporogenesis and phasiRNA target regulation.
Lian JP, Yang YW, He RR, Yang L, Zhou YF, Lei MQ, Zhang Z, Huang JH, Cheng Y, Liu YW, Zhang YC, Chen YQ
The Plant cell 2021 Aug 31;33(8):2685-2700
The Plant cell 2021 Aug 31;33(8):2685-2700
Anaplasma phagocytophilum AptA enhances the UPS, autophagy, and anti-apoptosis of host cells by PSMG3.
Ma Z, Li R, Hu R, Zheng W, Yu S, Cheng K, Zhang H, Xiao Y, Yi J, Wang Z, Wang Y, Chen C
International journal of biological macromolecules 2021 Aug 1;184:497-508
International journal of biological macromolecules 2021 Aug 1;184:497-508
Anti-tumor activity of a novel proteasome inhibitor D395 against multiple myeloma and its lower cardiotoxicity compared with carfilzomib.
Shen X, Wu C, Lei M, Yan Q, Zhang H, Zhang L, Wang X, Yang Y, Li J, Zhu Y, Chen L
Cell death & disease 2021 Apr 30;12(5):429
Cell death & disease 2021 Apr 30;12(5):429
Tauroursodeoxycholic acid attenuates cisplatin-induced ototoxicity by inhibiting the accumulation and aggregation of unfolded or misfolded proteins in the endoplasmic reticulum.
Wen Y, Zong S, Liu T, Du P, Li H, Xiao H
Toxicology 2021 Apr 15;453:152736
Toxicology 2021 Apr 15;453:152736
FBXL10 promotes ERRα protein stability and proliferation of breast cancer cells by enhancing the mono-ubiquitylation of ERRα.
Yang Y, Li S, Li B, Li Y, Xia K, Aman S, Yang Y, Ahmad B, Zhao B, Wu H
Cancer letters 2021 Apr 1;502:108-119
Cancer letters 2021 Apr 1;502:108-119
Cancer Cell enters reversible quiescence through Intracellular Acidification to resist Paclitaxel Cytotoxicity.
Jia M, Zheng D, Wang X, Zhang Y, Chen S, Cai X, Mo L, Hu Z, Li H, Zhou Z, Li J
International journal of medical sciences 2020;17(11):1652-1664
International journal of medical sciences 2020;17(11):1652-1664
Parkin interacts with Mitofilin to increase dopaminergic neuron death in response to Parkinson's disease-related stressors.
Imam Aliagan AD, Ahwazi MD, Tombo N, Feng Y, Bopassa JC
American journal of translational research 2020;12(11):7542-7564
American journal of translational research 2020;12(11):7542-7564
HDAC6, A Novel Cargo for Autophagic Clearance of Stress Granules, Mediates the Repression of the Type I Interferon Response During Coxsackievirus A16 Infection.
Zheng Y, Zhu G, Tang Y, Yan J, Han S, Yin J, Peng B, He X, Liu W
Frontiers in microbiology 2020;11:78
Frontiers in microbiology 2020;11:78
Ubiquitin E3 Ligase c-Cbl Is a Host Negative Regulator of Nef Protein of HIV-1.
Zhang HG, Guo J, Yuan Y, Zuo Y, Liu J, Zhu L, Miao Y, Chen X, Jin L, Huang F, Ren T, He J, Shi W, Wen Z, Zhu C, Zheng H, Dong C, Qian F
Frontiers in microbiology 2020;11:597972
Frontiers in microbiology 2020;11:597972
SPOP attenuates migration and invasion of choriocarcinoma cells by promoting DHX9 degradation.
Yuan D, Chen Y, Yang Z, Li G, Wu M, Jiang J, Li D, Yu Q
American journal of cancer research 2020;10(8):2428-2445
American journal of cancer research 2020;10(8):2428-2445
WDHD1 Leads to Cisplatin Resistance by Promoting MAPRE2 Ubiquitination in Lung Adenocarcinoma.
Gong L, Xiao M, He D, Hu Y, Zhu Y, Xiang L, Bao Y, Liu X, Zeng Q, Liu J, Zhou M, Zhou Y, Cheng Y, Zhang Y, Deng L, Zhu R, Lan H, Cao K
Frontiers in oncology 2020;10:461
Frontiers in oncology 2020;10:461
p53 Affects PGC1α Stability Through AKT/GSK-3β to Enhance Cisplatin Sensitivity in Non-Small Cell Lung Cancer.
Deng X, Li Y, Gu S, Chen Y, Yu B, Su J, Sun L, Liu Y
Frontiers in oncology 2020;10:1252
Frontiers in oncology 2020;10:1252
Tobramycin suppresses HUWE1 degradation to control MCL-1 stability during tumour development.
He J, Wu S, Li X, Tang L, Chen H, Qin L, Xie J, Lu T, Xu W
Clinical and experimental pharmacology & physiology 2020 Sep;47(9):1600-1610
Clinical and experimental pharmacology & physiology 2020 Sep;47(9):1600-1610
Crosstalk between cardiomyocytes and noncardiomyocytes is essential to prevent cardiomyocyte apoptosis induced by proteasome inhibition.
Guo F, Zhang CC, Yin XH, Li T, Fang CH, He XB
Cell death & disease 2020 Sep 19;11(9):783
Cell death & disease 2020 Sep 19;11(9):783
The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models.
Wu H, Sun H, He Z, Chen X, Li Y, Zhao X, Kong W, Kong W
Experimental cell research 2020 Sep 1;394(1):112093
Experimental cell research 2020 Sep 1;394(1):112093
Involvement of p53 Acetylation in Growth Suppression of Cutaneous T-Cell Lymphomas Induced by HDAC Inhibition.
Yu X, Li H, Zhu M, Hu P, Liu X, Qing Y, Wang X, Wang H, Wang Z, Xu J, Tan R, Guo Q, Hui H
The Journal of investigative dermatology 2020 Oct;140(10):2009-2022.e4
The Journal of investigative dermatology 2020 Oct;140(10):2009-2022.e4
LINC00452 promotes ovarian carcinogenesis through increasing ROCK1 by sponging miR-501-3p and suppressing ubiquitin-mediated degradation.
Yang J, Wang WG, Zhang KQ
Aging 2020 Nov 9;12(21):21129-21146
Aging 2020 Nov 9;12(21):21129-21146
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis.
Li ST, Huang D, Shen S, Cai Y, Xing S, Wu G, Jiang Z, Hao Y, Yuan M, Wang N, Zhu L, Yan R, Yang D, Wang L, Liu Z, Hu X, Zhou R, Qu K, Li A, Duan X, Zhang H, Gao P
Nature metabolism 2020 Mar;2(3):256-269
Nature metabolism 2020 Mar;2(3):256-269
SUMOylation Protects FASN Against Proteasomal Degradation in Breast Cancer Cells Treated with Grape Leaf Extract.
Floris A, Mazarei M, Yang X, Robinson AE, Zhou J, Barberis A, D'hallewin G, Azara E, Spissu Y, Iglesias-Ara A, Orrù S, Tomasi ML
Biomolecules 2020 Mar 31;10(4)
Biomolecules 2020 Mar 31;10(4)
α-synuclein strains that cause distinct pathologies differentially inhibit proteasome.
Suzuki G, Imura S, Hosokawa M, Katsumata R, Nonaka T, Hisanaga SI, Saeki Y, Hasegawa M
eLife 2020 Jul 22;9
eLife 2020 Jul 22;9
Arabidopsis SINAT Proteins Control Autophagy by Mediating Ubiquitylation and Degradation of ATG13.
Qi H, Li J, Xia FN, Chen JY, Lei X, Han MQ, Xie LJ, Zhou QM, Xiao S
The Plant cell 2020 Jan;32(1):263-284
The Plant cell 2020 Jan;32(1):263-284
Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages.
He X, Chen S, Li C, Ban J, Wei Y, He Y, Liu F, Chen Y, Chen J
Cells 2020 Jan 4;9(1)
Cells 2020 Jan 4;9(1)
A robust TDP-43 knock-in mouse model of ALS.
Huang SL, Wu LS, Lee M, Chang CW, Cheng WC, Fang YS, Chen YR, Cheng PL, Shen CJ
Acta neuropathologica communications 2020 Jan 21;8(1):3
Acta neuropathologica communications 2020 Jan 21;8(1):3
Voltage-gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation.
Li S, Han J, Guo G, Sun Y, Zhang T, Zhao M, Xu Y, Cui Y, Liu Y, Zhang J
FEBS letters 2020 Feb;594(3):497-508
FEBS letters 2020 Feb;594(3):497-508
Lanosterol modulates proteostasis via dissolving cytosolic sequestosomes/aggresome-like induced structures.
Hu LD, Wang J, Chen XJ, Yan YB
Biochimica et biophysica acta. Molecular cell research 2020 Feb;1867(2):118617
Biochimica et biophysica acta. Molecular cell research 2020 Feb;1867(2):118617
Hydrogen sulfide regulates muscle RING finger-1 protein S-sulfhydration at Cys(44) to prevent cardiac structural damage in diabetic cardiomyopathy.
Sun X, Zhao D, Lu F, Peng S, Yu M, Liu N, Sun Y, Du H, Wang B, Chen J, Dong S, Lu F, Zhang W
British journal of pharmacology 2020 Feb;177(4):836-856
British journal of pharmacology 2020 Feb;177(4):836-856
Down-Regulated CUEDC2 Increases GDNF Expression by Stabilizing CREB Through Reducing Its Ubiquitination in Glioma.
Liu XF, Tang CX, Zhang L, Tong SY, Wang Y, Abdulrahman AA, Ji GQ, Gao Y, Gao DS, Zhang BL
Neurochemical research 2020 Dec;45(12):2915-2925
Neurochemical research 2020 Dec;45(12):2915-2925
MAFG-AS1 promotes tumor progression via regulation of the HuR/PTBP1 axis in bladder urothelial carcinoma.
Xiao M, Liu J, Xiang L, Zhao K, He D, Zeng Q, Zhang Q, Xie D, Deng M, Zhu Y, Zhang Y, Liu Y, Bo H, Liu X, Chen X, Gong L, Bao Y, Hu Y, Cheng Y, Deng L, Zhu R, Xing X, Zhou M, Xiong W, Zhou Y, Zhou J, Li X, Cao K
Clinical and translational medicine 2020 Dec;10(8):e241
Clinical and translational medicine 2020 Dec;10(8):e241
PHLDA1 promotes microglia-mediated neuroinflammation via regulating K63-linked ubiquitination of TRAF6.
Han C, Yan P, He T, Cheng J, Zheng W, Zheng LT, Zhen X
Brain, behavior, and immunity 2020 Aug;88:640-653
Brain, behavior, and immunity 2020 Aug;88:640-653
Hydrogen sulphide ameliorating skeletal muscle atrophy in db/db mice via Muscle RING finger 1 S-sulfhydration.
Lu F, Lu B, Zhang L, Wen J, Wang M, Zhang S, Li Q, Shu F, Sun Y, Liu N, Peng S, Zhao Y, Dong S, Zhao D, Lu F, Zhang W
Journal of cellular and molecular medicine 2020 Aug;24(16):9362-9377
Journal of cellular and molecular medicine 2020 Aug;24(16):9362-9377
Long non-coding RNA LOC100133669 promotes cell proliferation in oesophageal squamous cell carcinoma.
Guan Z, Wang Y, Wang Y, Liu X, Wang Y, Zhang W, Chi X, Dong Y, Liu X, Shao S, Zhan Q
Cell proliferation 2020 Apr;53(4):e12750
Cell proliferation 2020 Apr;53(4):e12750
Exogenous H(2)S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.
Sun Y, Lu F, Yu X, Wang B, Chen J, Lu F, Peng S, Sun X, Yu M, Chen H, Wang Y, Zhang L, Liu N, Du H, Zhao D, Zhang W
Aging and disease 2020 Apr;11(2):269-285
Aging and disease 2020 Apr;11(2):269-285
Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6/TAK1/MAPK and Nrf2 Signaling Pathway.
Liao HH, Zhang N, Meng YY, Feng H, Yang JJ, Li WJ, Chen S, Wu HM, Deng W, Tang QZ
Oxidative medicine and cellular longevity 2019;2019:6304058
Oxidative medicine and cellular longevity 2019;2019:6304058
The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein.
Wu L, Lin Y, Feng J, Qi Y, Wang X, Lin Q, Shi W, Zheng E, Wang W, Hou Z, Lin H, Yu C, He Y, Xu Y, Yang H, Lin L, Li L
Cancer cell international 2019;19:222
Cancer cell international 2019;19:222
STAT3 Regulates the Type I IFN-Mediated Antiviral Response by Interfering with the Nuclear Entry of STAT1.
Wang H, Yuan M, Wang S, Zhang L, Zhang R, Zou X, Wang X, Chen D, Wu Z
International journal of molecular sciences 2019 Sep 30;20(19)
International journal of molecular sciences 2019 Sep 30;20(19)
Long Noncoding RNA-DACH1 (Dachshund Homolog 1) Regulates Cardiac Function by Inhibiting SERCA2a (Sarcoplasmic Reticulum Calcium ATPase 2a).
Cai B, Zhang Y, Zhao Y, Wang J, Li T, Zhang Y, Jiang Y, Jin X, Xue G, Li P, Sun Y, Huang Q, Zhang X, Su W, Yang Y, Sun Y, Shi L, Li X, Lu Y, Yang B, Pan Z
Hypertension (Dallas, Tex. : 1979) 2019 Oct;74(4):833-842
Hypertension (Dallas, Tex. : 1979) 2019 Oct;74(4):833-842
Cinobufotalin powerfully reversed EBV-miR-BART22-induced cisplatin resistance via stimulating MAP2K4 to antagonize non-muscle myosin heavy chain IIA/glycogen synthase 3β/β-catenin signaling pathway.
Liu Y, Jiang Q, Liu X, Lin X, Tang Z, Liu C, Zhou J, Zhao M, Li X, Cheng Z, Li L, Xie Y, Liu Z, Fang W
EBioMedicine 2019 Oct;48:386-404
EBioMedicine 2019 Oct;48:386-404
Autophagy protects HUVECs against ER stress-mediated apoptosis under simulated microgravity.
Li CF, Pan YK, Gao Y, Shi F, Wang YC, Sun XQ
Apoptosis : an international journal on programmed cell death 2019 Oct;24(9-10):812-825
Apoptosis : an international journal on programmed cell death 2019 Oct;24(9-10):812-825
The immunoproteasome catalytic β5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation.
Xie X, Bi HL, Lai S, Zhang YL, Li N, Cao HJ, Han L, Wang HX, Li HH
Science advances 2019 May;5(5):eaau0495
Science advances 2019 May;5(5):eaau0495
Nilotinib: A Tyrosine Kinase Inhibitor Mediates Resistance to Intracellular Mycobacterium Via Regulating Autophagy.
Hussain T, Zhao D, Shah SZA, Sabir N, Wang J, Liao Y, Song Y, Dong H, Hussain Mangi M, Ni J, Yang L, Zhou X
Cells 2019 May 26;8(5)
Cells 2019 May 26;8(5)
The endogenous retrovirus-derived long noncoding RNA TROJAN promotes triple-negative breast cancer progression via ZMYND8 degradation.
Jin X, Xu XE, Jiang YZ, Liu YR, Sun W, Guo YJ, Ren YX, Zuo WJ, Hu X, Huang SL, Shen HJ, Lan F, He YF, Hu GH, Di GH, He XH, Li DQ, Liu S, Yu KD, Shao ZM
Science advances 2019 Mar;5(3):eaat9820
Science advances 2019 Mar;5(3):eaat9820
THZ1 suppresses human non-small-cell lung cancer cells in vitro through interference with cancer metabolism.
Cheng ZJ, Miao DL, Su QY, Tang XL, Wang XL, Deng LB, Shi HD, Xin HB
Acta pharmacologica Sinica 2019 Jun;40(6):814-822
Acta pharmacologica Sinica 2019 Jun;40(6):814-822
Fludarabine as an Adjuvant Improves Newcastle Disease Virus-Mediated Antitumor Immunity in Hepatocellular Carcinoma.
Meng G, Fei Z, Fang M, Li B, Chen A, Xu C, Xia M, Yu D, Wei J
Molecular therapy oncolytics 2019 Jun 28;13:22-34
Molecular therapy oncolytics 2019 Jun 28;13:22-34
Autosomal dominant mitochondrial membrane protein-associated neurodegeneration (MPAN).
Gregory A, Lotia M, Jeong SY, Fox R, Zhen D, Sanford L, Hamada J, Jahic A, Beetz C, Freed A, Kurian MA, Cullup T, van der Weijden MCM, Nguyen V, Setthavongsack N, Garcia D, Krajbich V, Pham T, Woltjer R, George BP, Minks KQ, Paciorkowski AR, Hogarth P, Jankovic J, Hayflick SJ
Molecular genetics & genomic medicine 2019 Jul;7(7):e00736
Molecular genetics & genomic medicine 2019 Jul;7(7):e00736
TRIM28 protects CARM1 from proteasome-mediated degradation to prevent colorectal cancer metastasis.
Cui J, Hu J, Ye Z, Fan Y, Li Y, Wang G, Wang L, Wang Z
Science bulletin 2019 Jul 30;64(14):986-997
Science bulletin 2019 Jul 30;64(14):986-997
Hsp90ab1 stabilizes LRP5 to promote epithelial-mesenchymal transition via activating of AKT and Wnt/β-catenin signaling pathways in gastric cancer progression.
Wang H, Deng G, Ai M, Xu Z, Mou T, Yu J, Liu H, Wang S, Li G
Oncogene 2019 Feb;38(9):1489-1507
Oncogene 2019 Feb;38(9):1489-1507
YY1-regulated LINC00152 promotes triple negative breast cancer progression by affecting on stability of PTEN protein.
Shen X, Zhong J, Yu P, Zhao Q, Huang T
Biochemical and biophysical research communications 2019 Feb 5;509(2):448-454
Biochemical and biophysical research communications 2019 Feb 5;509(2):448-454
Kindlin-2 links mechano-environment to proline synthesis and tumor growth.
Guo L, Cui C, Zhang K, Wang J, Wang Y, Lu Y, Chen K, Yuan J, Xiao G, Tang B, Sun Y, Wu C
Nature communications 2019 Feb 19;10(1):845
Nature communications 2019 Feb 19;10(1):845
Downregulation of MUTYH contributes to cisplatin‑resistance of esophageal squamous cell carcinoma cells by promoting Twist‑mediated EMT.
Guo Y, Jia Y, Wang S, Liu N, Gao D, Zhang L, Lin Z, Wang S, Kong F, Peng C, Liu Y
Oncology reports 2019 Dec;42(6):2716-2727
Oncology reports 2019 Dec;42(6):2716-2727
USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication.
Pan T, Song Z, Wu L, Liu G, Ma X, Peng Z, Zhou M, Liang L, Liu B, Liu J, Zhang J, Zhang X, Huang R, Zhao J, Li Y, Ling X, Luo Y, Tang X, Cai W, Deng K, Li L, Zhang H
eLife 2019 Aug 9;8
eLife 2019 Aug 9;8
Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy.
Cai Q, Wang S, Jin L, Weng M, Zhou D, Wang J, Tang Z, Quan Z
Molecular cancer 2019 Apr 5;18(1):82
Molecular cancer 2019 Apr 5;18(1):82
Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice.
Duan W, Guo M, Yi L, Zhang J, Bi Y, Liu Y, Li Y, Li Z, Ma Y, Zhang G, Liu Y, Song X, Li C
Aging 2019 Apr 30;11(8):2457-2476
Aging 2019 Apr 30;11(8):2457-2476
TRIM59 regulates autophagy through modulating both the transcription and the ubiquitination of BECN1.
Han T, Guo M, Gan M, Yu B, Tian X, Wang JB
Autophagy 2018;14(12):2035-2048
Autophagy 2018;14(12):2035-2048
M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole.
Huang N, Zhang D, Li F, Chai P, Wang S, Teng J, Chen J
Nature communications 2018 Oct 30;9(1):4511
Nature communications 2018 Oct 30;9(1):4511
Pyk2 deficiency potentiates osteoblast differentiation and mineralizing activity in response to estrogen or raloxifene.
Posritong S, Hong JM, Eleniste PP, McIntyre PW, Wu JL, Himes ER, Patel V, Kacena MA, Bruzzaniti A
Molecular and cellular endocrinology 2018 Oct 15;474:35-47
Molecular and cellular endocrinology 2018 Oct 15;474:35-47
14-3-3ζ binds to hepatitis B virus protein X and maintains its protein stability in hepatocellular carcinoma cells.
Tang Y, Zhang Y, Wang C, Sun Z, Li L, Dong J, Zhou W
Cancer medicine 2018 Nov;7(11):5543-5553
Cancer medicine 2018 Nov;7(11):5543-5553
Downregulation of glycine decarboxylase enhanced cofilin-mediated migration in hepatocellular carcinoma cells.
Zhuang H, Li Q, Zhang X, Ma X, Wang Z, Liu Y, Yi X, Chen R, Han F, Zhang N, Li Y
Free radical biology & medicine 2018 May 20;120:1-12
Free radical biology & medicine 2018 May 20;120:1-12
Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation.
Guo XB, Deng X, Wei Y
Stem cells (Dayton, Ohio) 2018 Mar;36(3):406-419
Stem cells (Dayton, Ohio) 2018 Mar;36(3):406-419
Identification of Residues Controlling Restriction versus Enhancing Activities of IFITM Proteins on Entry of Human Coronaviruses.
Zhao X, Sehgal M, Hou Z, Cheng J, Shu S, Wu S, Guo F, Le Marchand SJ, Lin H, Chang J, Guo JT
Journal of virology 2018 Mar 15;92(6)
Journal of virology 2018 Mar 15;92(6)
CRISPR/Cas9-Targeted Deletion of Polyglutamine in Spinocerebellar Ataxia Type 3-Derived Induced Pluripotent Stem Cells.
Ouyang S, Xie Y, Xiong Z, Yang Y, Xian Y, Ou Z, Song B, Chen Y, Xie Y, Li H, Sun X
Stem cells and development 2018 Jun 1;27(11):756-770
Stem cells and development 2018 Jun 1;27(11):756-770
Ubiquitin-Specific Protease USP6 Regulates the Stability of the c-Jun Protein.
Li L, Yang H, He Y, Li T, Feng J, Chen W, Ao L, Shi X, Lin Y, Liu H, Zheng E, Lin Q, Bu J, Zeng Y, Zheng M, Xu Y, Liao Z, Lin J, Lin D
Molecular and cellular biology 2018 Jan 15;38(2)
Molecular and cellular biology 2018 Jan 15;38(2)
SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer.
Xiong Y, Wang L, Wang S, Wang M, Zhao J, Zhang Z, Li X, Jia L, Han Y
Journal of cancer research and clinical oncology 2018 Feb;144(2):189-198
Journal of cancer research and clinical oncology 2018 Feb;144(2):189-198
The N-terminal ubiquitin-associated domain of Cezanne is crucial for its function to suppress NF-κB pathway.
Ji Y, Cao L, Zeng L, Zhang Z, Xiao Q, Guan P, Chen S, Chen Y, Wang M, Guo D
Journal of cellular biochemistry 2018 Feb;119(2):1979-1991
Journal of cellular biochemistry 2018 Feb;119(2):1979-1991
Temozolomide-perillyl alcohol conjugate downregulates O(6)-methylguanin DNA methltransferase via inducing ubiquitination-dependent proteolysis in non-small cell lung cancer.
Song X, Xie L, Chang M, Geng X, Wang X, Chen TC, Song X
Cell death & disease 2018 Feb 9;9(2):202
Cell death & disease 2018 Feb 9;9(2):202
The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma.
Li Z, Zhang J, Liu X, Li S, Wang Q, Di Chen, Hu Z, Yu T, Ding J, Li J, Yao M, Fan J, Huang S, Gao Q, Zhao Y, He X
Nature communications 2018 Apr 20;9(1):1572
Nature communications 2018 Apr 20;9(1):1572
Role of the Ubiquitin C-Terminal Hydrolase L1-Modulated Ubiquitin Proteasome System in Auditory Cortex Senescence.
Zhang Y, Huang X, Zhao XY, Hu YJ, Sun HY, Kong WJ
ORL; journal for oto-rhino-laryngology and its related specialties 2017;79(3):153-163
ORL; journal for oto-rhino-laryngology and its related specialties 2017;79(3):153-163
Endoplasmic Reticulum Stress Is Involved in Cochlear Cell Apoptosis in a Cisplatin-Induced Ototoxicity Rat Model.
Zong S, Liu T, Wan F, Chen P, Luo P, Xiao H
Audiology & neuro-otology 2017;22(3):160-168
Audiology & neuro-otology 2017;22(3):160-168
HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway.
Deng X, Song L, Zhao W, Wei Y, Guo XB
Frontiers in cellular neuroscience 2017;11:420
Frontiers in cellular neuroscience 2017;11:420
MDM2 Contributes to High Glucose-Induced Glomerular Mesangial Cell Proliferation and Extracellular Matrix Accumulation via Notch1.
Lei CT, Tang H, Ye C, You CQ, Zhang J, Zhang CY, Xiong W, Su H, Zhang C
Scientific reports 2017 Sep 4;7(1):10393
Scientific reports 2017 Sep 4;7(1):10393
Liposomal honokiol induced lysosomal degradation of Hsp90 client proteins and protective autophagy in both gefitinib-sensitive and gefitinib-resistant NSCLC cells.
Yang J, Wu W, Wen J, Ye H, Luo H, Bai P, Tang M, Wang F, Zheng L, Yang S, Li W, Peng A, Yang L, Wan L, Chen L
Biomaterials 2017 Oct;141:188-198
Biomaterials 2017 Oct;141:188-198
Exogenous H(2)S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.
Wu J, Tian Z, Sun Y, Lu C, Liu N, Gao Z, Zhang L, Dong S, Yang F, Zhong X, Xu C, Lu F, Zhang W
Cell death & disease 2017 Aug 10;8(8):e2992
Cell death & disease 2017 Aug 10;8(8):e2992
AMPK Serves as a Therapeutic Target Against Anemia of Inflammation.
Wang M, Xin H, Tang W, Li Y, Zhang Z, Fan L, Miao L, Tan B, Wang X, Zhu YZ
Antioxidants & redox signaling 2017 Aug 10;27(5):251-268
Antioxidants & redox signaling 2017 Aug 10;27(5):251-268
A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer.
Wu YH, Hong CW, Wang YC, Huang WJ, Yeh YL, Wang BJ, Wang YJ, Chiu HW
Cancer letters 2017 Aug 1;400:79-88
Cancer letters 2017 Aug 1;400:79-88
TRAF Family Proteins Regulate Autophagy Dynamics by Modulating AUTOPHAGY PROTEIN6 Stability in Arabidopsis.
Qi H, Xia FN, Xie LJ, Yu LJ, Chen QF, Zhuang XH, Wang Q, Li F, Jiang L, Xie Q, Xiao S
The Plant cell 2017 Apr;29(4):890-911
The Plant cell 2017 Apr;29(4):890-911
A novel glutaminase inhibitor-968 inhibits the migration and proliferation of non-small cell lung cancer cells by targeting EGFR/ERK signaling pathway.
Han T, Guo M, Zhang T, Gan M, Xie C, Wang JB
Oncotarget 2017 Apr 25;8(17):28063-28073
Oncotarget 2017 Apr 25;8(17):28063-28073
The N-Terminal of Aquareovirus NS80 Is Required for Interacting with Viral Proteins and Viral Replication.
Zhang J, Guo H, Chen Q, Zhang F, Fang Q
PloS one 2016;11(2):e0148550
PloS one 2016;11(2):e0148550
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness.
Khare S, Nagle AS, Biggart A, Lai YH, Liang F, Davis LC, Barnes SW, Mathison CJ, Myburgh E, Gao MY, Gillespie JR, Liu X, Tan JL, Stinson M, Rivera IC, Ballard J, Yeh V, Groessl T, Federe G, Koh HX, Venable JD, Bursulaya B, Shapiro M, Mishra PK, Spraggon G, Brock A, Mottram JC, Buckner FS, Rao SP, Wen BG, Walker JR, Tuntland T, Molteni V, Glynne RJ, Supek F
Nature 2016 Sep 8;537(7619):229-233
Nature 2016 Sep 8;537(7619):229-233
Far-infrared promotes burn wound healing by suppressing NLRP3 inflammasome caused by enhanced autophagy.
Chiu HW, Chen CH, Chang JN, Chen CH, Hsu YH
Journal of molecular medicine (Berlin, Germany) 2016 Jul;94(7):809-19
Journal of molecular medicine (Berlin, Germany) 2016 Jul;94(7):809-19
Nogo-B receptor promotes the chemoresistance of human hepatocellular carcinoma via the ubiquitination of p53 protein.
Dong C, Zhao B, Long F, Liu Y, Liu Z, Li S, Yang X, Sun D, Wang H, Liu Q, Liang R, Li Y, Gao Z, Shao S, Miao QR, Wang L
Oncotarget 2016 Feb 23;7(8):8850-65
Oncotarget 2016 Feb 23;7(8):8850-65
Proteomic analysis of apoptosis induction by lariciresinol in human HepG2 cells.
Ma ZJ, Wang XX, Su G, Yang JJ, Zhu YJ, Wu YW, Li J, Lu L, Zeng L, Pei HX
Chemico-biological interactions 2016 Aug 25;256:209-19
Chemico-biological interactions 2016 Aug 25;256:209-19
The Ubiquitin-like Protein FAT10 Stabilizes eEF1A1 Expression to Promote Tumor Proliferation in a Complex Manner.
Liu X, Chen L, Ge J, Yan C, Huang Z, Hu J, Wen C, Li M, Huang D, Qiu Y, Hao H, Yuan R, Lei J, Yu X, Shao J
Cancer research 2016 Aug 15;76(16):4897-907
Cancer research 2016 Aug 15;76(16):4897-907
Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon.
Xiao J, Duan Q, Wang Z, Yan W, Sun H, Xue P, Fan X, Zeng X, Chen J, Shao C, Zhu F
Oncotarget 2016 Apr 26;7(17):24483-94
Oncotarget 2016 Apr 26;7(17):24483-94
The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.
Liu F, Zhang W, You X, Liu Y, Li Y, Wang Z, Wang Y, Zhang X, Ye L
Oncotarget 2015 Sep 29;6(29):27199-213
Oncotarget 2015 Sep 29;6(29):27199-213
DEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase.
Bi H, Li S, Qu X, Wang M, Bai X, Xu Z, Ao X, Jia Z, Jiang X, Yang Y, Wu H
Cell death & disease 2015 Sep 24;6(9):e1891
Cell death & disease 2015 Sep 24;6(9):e1891
The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer.
Li H, Liu Q, Wang Z, Fang R, Shen Y, Cai X, Gao Y, Li Y, Zhang X, Ye L
The Journal of biological chemistry 2015 Sep 11;290(37):22649-61
The Journal of biological chemistry 2015 Sep 11;290(37):22649-61
Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins.
Zhang W, Zhang L, Zan Y, Du N, Yang Y, Tien P
The Journal of general virology 2015 Jan;96(Pt 1):170-182
The Journal of general virology 2015 Jan;96(Pt 1):170-182
Rock2 promotes the invasion and metastasis of hepatocellular carcinoma by modifying MMP2 ubiquitination and degradation.
Huang D, Du X, Yuan R, Chen L, Liu T, Wen C, Huang M, Li M, Hao L, Shao J
Biochemical and biophysical research communications 2014 Oct 10;453(1):49-56
Biochemical and biophysical research communications 2014 Oct 10;453(1):49-56
Clinicopathologic report of ocular involvement in ALS patients with C9orf72 mutation.
Fawzi AA, Simonett JM, Purta P, Moss HE, Lowry JL, Deng HX, Siddique N, Sufit R, Bigio EH, Volpe NJ, Siddique T
Amyotrophic lateral sclerosis & frontotemporal degeneration 2014 Dec;15(7-8):569-80
Amyotrophic lateral sclerosis & frontotemporal degeneration 2014 Dec;15(7-8):569-80
Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility.
Zhu Z, Liu Y, Li K, Liu J, Wang H, Sun B, Xiong Z, Jiang H, Zheng J, Hu Z
Carcinogenesis 2014 Aug;35(8):1901-10
Carcinogenesis 2014 Aug;35(8):1901-10
Ubiquitin B in cervical cancer: critical for the maintenance of cancer stem-like cell characters.
Tian Y, Ding W, Wang Y, Ji T, Sun S, Mo Q, Chen P, Fang Y, Liu J, Wang B, Zhou J, Ma D, Wu P
PloS one 2013;8(12):e84457
PloS one 2013;8(12):e84457
Downregulation of the ubiquitin-proteasome system in normal colonic macrophages and reinduction in inflammatory bowel disease.
Hetzenecker AM, Seidl MC, Kosovac K, Herfarth H, Kellermeier S, Obermeier F, Falk W, Schoelmerich J, Hausmann M, Rogler G
Digestion 2012;86(1):34-47
Digestion 2012;86(1):34-47
Amyloid precursor protein accumulates in aggresomes in response to proteasome inhibitor.
Dehvari N, Mahmud T, Persson J, Bengtsson T, Graff C, Winblad B, Rönnbäck A, Behbahani H
Neurochemistry international 2012 Apr;60(5):533-42
Neurochemistry international 2012 Apr;60(5):533-42
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 10201-2-AP( ubiquitin Antibody) at dilution of 1:600
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human ovary tumor using 10201-2-AP(ubiquitin antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ubiquitin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ubiquitin. This antibody recognizes human,mouse,rat antigen. The ubiquitin antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
