12929-2-AP
antibody from Proteintech Group
Targeting: SRSF1
ASF, MGC5228, SF2, SF2p33, SFRS1, SRp30a
Antibody data
- Antibody Data
- Antigen structure
- References [30]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 12929-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12929-2-AP, RRID:AB_2187211
- Product name
- ASF/SF2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ASF/SF2 antibody (Cat. #12929-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references High expression of SRSF1 facilitates osteosarcoma progression and unveils its potential mechanisms.
TIM22 and TIM29 inhibit HBV replication by up-regulating SRSF1 expression.
LncRNA HOTAIR accelerates free fatty acid-induced inflammatory response in HepG2 cells by recruiting SRSF1 to stabilize MLXIPL mRNA.
SRSF1-mediated alternative splicing is required for spermatogenesis.
Long-read sequencing reveals the landscape of aberrant alternative splicing and novel therapeutic target in colorectal cancer.
SRSF1 is essential for primary follicle development by regulating granulosa cell survival via mRNA alternative splicing.
Targeting PRMT1-mediated SRSF1 methylation to suppress oncogenic exon inclusion events and breast tumorigenesis.
RNF125 attenuates hepatocellular carcinoma progression by downregulating SRSF1-ERK pathway.
HLTF promotes hepatocellular carcinoma progression by enhancing SRSF1 stability and activating ERK/MAPK pathway.
Photobiomodulation Drives MiR-136-5p Expression to Promote Injury Repair after Myocardial Infarction.
LncRNA DACH1 protects against pulmonary fibrosis by binding to SRSF1 to suppress CTNNB1 accumulation.
circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells.
NSrp70 suppresses metastasis in triple-negative breast cancer by modulating Numb/TβR1/EMT axis.
circSLC41A1 Resists Porcine Granulosa Cell Apoptosis and Follicular Atresia by Promoting SRSF1 through miR-9820-5p Sponging.
Extracellular matrix stiffness controls VEGF(165) secretion and neuroblastoma angiogenesis via the YAP/RUNX2/SRSF1 axis.
The long non-coding RNA PFI protects against pulmonary fibrosis by interacting with splicing regulator SRSF1.
SRSF protein kinase 1 modulates RAN translation and suppresses CGG repeat toxicity.
Sequence-dependent recruitment of SRSF1 and SRSF7 to intronless lncRNA NKILA promotes nuclear export via the TREX/TAP pathway.
An APEX2 proximity ligation method for mapping interactions with the nuclear lamina.
The SRSF1/circATP5B/miR-185-5p/HOXB5 feedback loop regulates the proliferation of glioma stem cells via the IL6-mediated JAK2/STAT3 signaling pathway.
LncRNA HOTAIR aggravates myocardial ischemia-reperfusion injury by sponging microRNA-126 to upregulate SRSF1.
CD63(+) Cancer-Associated Fibroblasts Confer Tamoxifen Resistance to Breast Cancer Cells through Exosomal miR-22.
CircFOXK2 Promotes Growth and Metastasis of Pancreatic Ductal Adenocarcinoma by Complexing with RNA-Binding Proteins and Sponging MiR-942.
Long noncoding RNA HOXA11-AS promotes gastric cancer cell proliferation and invasion via SRSF1 and functions as a biomarker in gastric cancer.
SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE.
Defensive effect of microRNA-200b/c against amyloid-beta peptide-induced toxicity in Alzheimer's disease models.
Zc3h13 Regulates Nuclear RNA m(6)A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth.
PP1γ functionally augments the alternative splicing of CaMKIIδ through interaction with ASF.
Rescue of cardiac failing and remodelling by inhibition of protein phosphatase 1γ is associated with suppression of the alternative splicing factor-mediated splicing of Ca2+/calmodulin-dependent protein kinase δ.
Li S, Huang X, Zheng S, Zhang W, Liu F, Cao Q
BMC cancer 2024 May 12;24(1):580
BMC cancer 2024 May 12;24(1):580
TIM22 and TIM29 inhibit HBV replication by up-regulating SRSF1 expression.
Guo L, Liu JJ, Long SY, Wang PY, Li S, Wang JL, Wei XF, Li J, Lei L, Huang AL, Hu JL
Journal of medical virology 2024 Feb;96(2):e29439
Journal of medical virology 2024 Feb;96(2):e29439
LncRNA HOTAIR accelerates free fatty acid-induced inflammatory response in HepG2 cells by recruiting SRSF1 to stabilize MLXIPL mRNA.
Guo B, Yan S, Zhai L, Cheng Y
Cytotechnology 2024 Apr;76(2):259-269
Cytotechnology 2024 Apr;76(2):259-269
SRSF1-mediated alternative splicing is required for spermatogenesis.
Lei WL, Li YY, Du Z, Su R, Meng TG, Ning Y, Hou G, Schatten H, Wang ZB, Han Z, Sun F, Qian WP, Liu C, Sun QY
International journal of biological sciences 2023;19(15):4883-4897
International journal of biological sciences 2023;19(15):4883-4897
Long-read sequencing reveals the landscape of aberrant alternative splicing and novel therapeutic target in colorectal cancer.
Sun Q, Han Y, He J, Wang J, Ma X, Ning Q, Zhao Q, Jin Q, Yang L, Li S, Li Y, Zhi Q, Zheng J, Dong D
Genome medicine 2023 Sep 21;15(1):76
Genome medicine 2023 Sep 21;15(1):76
SRSF1 is essential for primary follicle development by regulating granulosa cell survival via mRNA alternative splicing.
Yao X, Wang C, Yu W, Sun L, Lv Z, Xie X, Tian S, Yan L, Zhang H, Liu J
Cellular and molecular life sciences : CMLS 2023 Oct 31;80(11):343
Cellular and molecular life sciences : CMLS 2023 Oct 31;80(11):343
Targeting PRMT1-mediated SRSF1 methylation to suppress oncogenic exon inclusion events and breast tumorigenesis.
Li WJ, Huang Y, Lin YA, Zhang BD, Li MY, Zou YQ, Hu GS, He YH, Yang JJ, Xie BL, Huang HH, Deng X, Liu W
Cell reports 2023 Nov 28;42(11):113385
Cell reports 2023 Nov 28;42(11):113385
RNF125 attenuates hepatocellular carcinoma progression by downregulating SRSF1-ERK pathway.
Feng Z, Ke S, Wang C, Lu S, Xu Y, Yu H, Li Z, Yin B, Li X, Hua Y, Qian B, Bai M, Fu Y, Zhang Y, Wu Y, Ma Y
Oncogene 2023 Jun;42(24):2017-2030
Oncogene 2023 Jun;42(24):2017-2030
HLTF promotes hepatocellular carcinoma progression by enhancing SRSF1 stability and activating ERK/MAPK pathway.
Xu Y, Ke S, Lu S, Wang C, Li Z, Feng Z, Yu H, Bai M, Qian B, Yin B, Li X, Hua Y, Jiang H, Ma Y
Oncogenesis 2023 Jan 20;12(1):2
Oncogenesis 2023 Jan 20;12(1):2
Photobiomodulation Drives MiR-136-5p Expression to Promote Injury Repair after Myocardial Infarction.
Gao X, Li H, Zhang W, Wang X, Sun H, Cao Y, Zhao Y, Ji H, Yang F, Ma W, Liu Y, Yang B, Cai B
International journal of biological sciences 2022;18(7):2980-2993
International journal of biological sciences 2022;18(7):2980-2993
LncRNA DACH1 protects against pulmonary fibrosis by binding to SRSF1 to suppress CTNNB1 accumulation.
Sun J, Jin T, Niu Z, Guo J, Guo Y, Yang R, Wang Q, Gao H, Zhang Y, Li T, He W, Li Z, Ma W, Su W, Li L, Fan X, Shan H, Liang H
Acta pharmaceutica Sinica. B 2022 Sep;12(9):3602-3617
Acta pharmaceutica Sinica. B 2022 Sep;12(9):3602-3617
circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells.
Li Q, Yao H, Wang Y, Wu Y, Thorne RF, Zhu Y, Wu M, Liu L
Cell reports 2022 Nov 22;41(8):111707
Cell reports 2022 Nov 22;41(8):111707
NSrp70 suppresses metastasis in triple-negative breast cancer by modulating Numb/TβR1/EMT axis.
Zhao Y, Sun H, Zhao Y, Liu Q, Liu Y, Hou Y, Jin W
Oncogene 2022 Jun;41(25):3409-3422
Oncogene 2022 Jun;41(25):3409-3422
circSLC41A1 Resists Porcine Granulosa Cell Apoptosis and Follicular Atresia by Promoting SRSF1 through miR-9820-5p Sponging.
Wang H, Zhang Y, Zhang J, Du X, Li Q, Pan Z
International journal of molecular sciences 2022 Jan 28;23(3)
International journal of molecular sciences 2022 Jan 28;23(3)
Extracellular matrix stiffness controls VEGF(165) secretion and neuroblastoma angiogenesis via the YAP/RUNX2/SRSF1 axis.
Bao M, Chen Y, Liu JT, Bao H, Wang WB, Qi YX, Lv F
Angiogenesis 2022 Feb;25(1):71-86
Angiogenesis 2022 Feb;25(1):71-86
The long non-coding RNA PFI protects against pulmonary fibrosis by interacting with splicing regulator SRSF1.
Sun J, Jin T, Su W, Guo Y, Niu Z, Guo J, Li L, Wang J, Ma L, Yu T, Li X, Zhou Y, Shan H, Liang H
Cell death and differentiation 2021 Oct;28(10):2916-2930
Cell death and differentiation 2021 Oct;28(10):2916-2930
SRSF protein kinase 1 modulates RAN translation and suppresses CGG repeat toxicity.
Malik I, Tseng YJ, Wright SE, Zheng K, Ramaiyer P, Green KM, Todd PK
EMBO molecular medicine 2021 Nov 8;13(11):e14163
EMBO molecular medicine 2021 Nov 8;13(11):e14163
Sequence-dependent recruitment of SRSF1 and SRSF7 to intronless lncRNA NKILA promotes nuclear export via the TREX/TAP pathway.
Khan M, Hou S, Azam S, Lei H
Nucleic acids research 2021 Jun 21;49(11):6420-6436
Nucleic acids research 2021 Jun 21;49(11):6420-6436
An APEX2 proximity ligation method for mapping interactions with the nuclear lamina.
Tran JR, Paulson DI, Moresco JJ, Adam SA, Yates JR, Goldman RD, Zheng Y
The Journal of cell biology 2021 Jan 4;220(1)
The Journal of cell biology 2021 Jan 4;220(1)
The SRSF1/circATP5B/miR-185-5p/HOXB5 feedback loop regulates the proliferation of glioma stem cells via the IL6-mediated JAK2/STAT3 signaling pathway.
Zhao J, Jiang Y, Zhang H, Zhou J, Chen L, Li H, Xu J, Zhang G, Jing Z
Journal of experimental & clinical cancer research : CR 2021 Apr 15;40(1):134
Journal of experimental & clinical cancer research : CR 2021 Apr 15;40(1):134
LncRNA HOTAIR aggravates myocardial ischemia-reperfusion injury by sponging microRNA-126 to upregulate SRSF1.
Sun Y, Hu ZQ
European review for medical and pharmacological sciences 2020 Sep;24(17):9046-9054
European review for medical and pharmacological sciences 2020 Sep;24(17):9046-9054
CD63(+) Cancer-Associated Fibroblasts Confer Tamoxifen Resistance to Breast Cancer Cells through Exosomal miR-22.
Gao Y, Li X, Zeng C, Liu C, Hao Q, Li W, Zhang K, Zhang W, Wang S, Zhao H, Fan D, Li M, Zhang Y, Zhang W, Zhang C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2020 Nov;7(21):2002518
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2020 Nov;7(21):2002518
CircFOXK2 Promotes Growth and Metastasis of Pancreatic Ductal Adenocarcinoma by Complexing with RNA-Binding Proteins and Sponging MiR-942.
Wong CH, Lou UK, Li Y, Chan SL, Tong JH, To KF, Chen Y
Cancer research 2020 Jun 1;80(11):2138-2149
Cancer research 2020 Jun 1;80(11):2138-2149
Long noncoding RNA HOXA11-AS promotes gastric cancer cell proliferation and invasion via SRSF1 and functions as a biomarker in gastric cancer.
Liu Y, Zhang YM, Ma FB, Pan SR, Liu BZ
World journal of gastroenterology 2019 Jun 14;25(22):2763-2775
World journal of gastroenterology 2019 Jun 14;25(22):2763-2775
SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE.
Raihan O, Brishti A, Li Q, Zhang Q, Li D, Li X, Zhang Q, Xie Z, Li J, Zhang J, Liu Q
Cell reports 2019 Jul 2;28(1):78-90.e6
Cell reports 2019 Jul 2;28(1):78-90.e6
Defensive effect of microRNA-200b/c against amyloid-beta peptide-induced toxicity in Alzheimer's disease models.
Higaki S, Muramatsu M, Matsuda A, Matsumoto K, Satoh JI, Michikawa M, Niida S
PloS one 2018;13(5):e0196929
PloS one 2018;13(5):e0196929
Zc3h13 Regulates Nuclear RNA m(6)A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Wen J, Lv R, Ma H, Shen H, He C, Wang J, Jiao F, Liu H, Yang P, Tan L, Lan F, Shi YG, He C, Shi Y, Diao J
Molecular cell 2018 Mar 15;69(6):1028-1038.e6
Molecular cell 2018 Mar 15;69(6):1028-1038.e6
Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth.
Chen Y, Huang Q, Liu W, Zhu Q, Cui CP, Xu L, Guo X, Wang P, Liu J, Dong G, Wei W, Liu CH, Feng Z, He F, Zhang L
Nature communications 2018 Jun 25;9(1):2464
Nature communications 2018 Jun 25;9(1):2464
PP1γ functionally augments the alternative splicing of CaMKIIδ through interaction with ASF.
Huang C, Cao W, Liao R, Wang J, Wang Y, Tong L, Chen X, Zhu W, Zhang W
American journal of physiology. Cell physiology 2014 Jan 15;306(2):C167-77
American journal of physiology. Cell physiology 2014 Jan 15;306(2):C167-77
Rescue of cardiac failing and remodelling by inhibition of protein phosphatase 1γ is associated with suppression of the alternative splicing factor-mediated splicing of Ca2+/calmodulin-dependent protein kinase δ.
Liao RJ, Tong LJ, Huang C, Cao WW, Wang YZ, Wang J, Chen XF, Zhu WZ, Zhang W
Clinical and experimental pharmacology & physiology 2014 Dec;41(12):976-85
Clinical and experimental pharmacology & physiology 2014 Dec;41(12):976-85
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ASF/SF2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ASF/SF2. This antibody recognizes human,mouse,rat antigen. The ASF/SF2 antibody has been validated for the following applications: ELISA, WB analysis.