17215-1-AP

antibody from Proteintech Group

Targeting: NLRX1 CLR11.3, NOD9

Provider product page for 17215-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [19]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 17215-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#17215-1-AP, RRID:AB_2236031
Product name: NLRX1 antibody
Antibody type: Polyclonal
Description: KD/KO validated NLRX1 antibody (Cat. #17215-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

NLRX1 protein structure - 17215-1-AP shown in red.

Submitted references NLRX1 knockdown attenuates pro-apoptotic signaling and cell death in pulmonary hyperoxic acute injury.

Kim HR, Kim MN, Kim EG, Leem JS, Baek SM, Lee YJ, Kim KW, Kang MJ, Song TW, Sohn MH
Scientific reports 2023 Mar 1;13(1):3441

Sex-Biased Control of Inflammation and Metabolism by a Mitochondrial Nod-Like Receptor.

Snäkä T, Bekkar A, Desponds C, Prével F, Claudinot S, Isorce N, Teixeira F, Grasset C, Xenarios I, Lopez-Mejia IC, Fajas L, Fasel N
Frontiers in immunology 2022;13:882867

The interaction of O-GlcNAc-modified NLRX1 and IKK-α modulates IL-1β expression in M1 macrophages.

Chen L, Li Y, Zeng S, Duan S, Huang Z, Liang Y
In vitro cellular & developmental biology. Animal 2022 May;58(5):408-418

Daming capsule protects against myocardial infarction by promoting mitophagy via the SIRT1/AMPK signaling pathway.

Sun X, Han Y, Dong C, Qu H, Yu Y, Ju J, Bai Y, Yang B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113162

Mitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1.

Killackey SA, Bi Y, Soares F, Hammi I, Winsor NJ, Abdul-Sater AA, Philpott DJ, Arnoult D, Girardin SE
Molecular cell 2022 Aug 4;82(15):2815-2831.e5

Xu X, Zhang D, Ding W, Wang W, Jin N, Ding Z
Veterinary microbiology 2021 Sep;260:109167

NLRX1 can counteract innate immune response induced by an external stimulus favoring HBV infection by competitive inhibition of MAVS-RLRs signaling in HepG2-NTCP cells.

Jiao Q, Xu W, Guo X, Liu H, Liao B, Zhu X, Chen C, Yang F, Wu L, Xie C, Peng L
Science progress 2021 Oct;104(4):368504211058036

The mitochondrial Nod-like receptor NLRX1 modifies apoptosis through SARM1.

Killackey SA, Rahman MA, Soares F, Zhang AB, Abdel-Nour M, Philpott DJ, Girardin SE
Molecular and cellular biochemistry 2019 Mar;453(1-2):187-196

Nucleotide-binding oligomerization domain-like receptor X1 restricts porcine reproductive and respiratory syndrome virus-2 replication by interacting with viral Nsp9.

Jing H, Song T, Cao S, Sun Y, Wang J, Dong W, Zhang Y, Ding Z, Wang T, Xing Z, Bao W
Virus research 2019 Jul 15;268:18-26

NLRX1 Facilitates Histoplasma capsulatum-Induced LC3-Associated Phagocytosis for Cytokine Production in Macrophages.

Huang JH, Liu CY, Wu SY, Chen WY, Chang TH, Kan HW, Hsieh ST, Ting JP, Wu-Hsieh BA
Frontiers in immunology 2018;9:2761

Regulatory NLRs Control the RLR-Mediated Type I Interferon and Inflammatory Responses in Human Dendritic Cells.

Fekete T, Bencze D, Szabo A, Csoma E, Biro T, Bacsi A, Pazmandi K
Frontiers in immunology 2018;9:2314

Activation of NLRX1-mediated autophagy accelerates the ototoxic potential of cisplatin in auditory cells.

Yin H, Yang Q, Cao Z, Li H, Yu Z, Zhang G, Sun G, Man R, Wang H, Li J
Toxicology and applied pharmacology 2018 Mar 15;343:16-28

FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1.

Kim JH, Park ME, Nikapitiya C, Kim TH, Uddin MB, Lee HC, Kim E, Ma JY, Jung JU, Kim CJ, Lee JS
PLoS pathogens 2017 May;13(5):e1006398

NLRX1 accelerates cisplatin-induced ototoxity in HEI-OC1 cells via promoting generation of ROS and activation of JNK signaling pathway.

Yin H, Sun G, Yang Q, Chen C, Qi Q, Wang H, Li J
Scientific reports 2017 Mar 13;7:44311

NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity.

Stokman G, Kors L, Bakker PJ, Rampanelli E, Claessen N, Teske GJD, Butter L, van Andel H, van den Bergh Weerman MA, Larsen PWB, Dessing MC, Zuurbier CJ, Girardin SE, Florquin S, Leemans JC
The Journal of experimental medicine 2017 Aug 7;214(8):2405-2420

Mitochondrial DNA stress primes the antiviral innate immune response.

West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, MacDuff DA, Kaech SM, Smiley JR, Means RE, Iwasaki A, Shadel GS
Nature 2015 Apr 23;520(7548):553-7

The mitochondrial protein NLRX1 controls the balance between extrinsic and intrinsic apoptosis.

Soares F, Tattoli I, Rahman MA, Robertson SJ, Belcheva A, Liu D, Streutker C, Winer S, Winer DA, Martin A, Philpott DJ, Arnoult D, Girardin SE
The Journal of biological chemistry 2014 Jul 11;289(28):19317-30

Nlrx1 regulates neuronal cell death.

Imbeault E, Mahvelati TM, Braun R, Gris P, Gris D
Molecular brain 2014 Dec 24;7:90

NLRX1 does not inhibit MAVS-dependent antiviral signalling.

Soares F, Tattoli I, Wortzman ME, Arnoult D, Philpott DJ, Girardin SE
Innate immunity 2013;19(4):438-48

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HEK-293 cells were subjected to SDS PAGE followed by western blot with 17215-1-AP(NLRX1 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using NLRX1 antibody 17215-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line