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- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 15666-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15666-1-AP, RRID:AB_2201149
- Product name
- SYNJ2BP antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SYNJ2BP antibody (Cat. #15666-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons.
SYNJ2BP ameliorates intervertebral disc degeneration by facilitating mitochondria-associated endoplasmic reticulum membrane formation and mitochondrial Zn(2+) homeostasis.
MTCH2 is a mitochondrial outer membrane protein insertase.
ATP13A1 prevents ERAD of folding-competent mislocalized and misoriented proteins.
Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy.
Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex.
Serine palmitoyltransferase assembles at ER-mitochondria contact sites.
The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase.
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
SYNJ2BP promotes the degradation of PTEN through the lysosome-pathway and enhances breast tumor metastasis via PI3K/AKT/SNAI1 signaling.
SYNJ2BP inhibits tumor growth and metastasis by activating DLL4 pathway in hepatocellular carcinoma.
Hees JT, Wanderoy S, Lindner J, Helms M, Murali Mahadevan H, Harbauer AB
Nature metabolism 2024 Mar;6(3):514-530
Nature metabolism 2024 Mar;6(3):514-530
SYNJ2BP ameliorates intervertebral disc degeneration by facilitating mitochondria-associated endoplasmic reticulum membrane formation and mitochondrial Zn(2+) homeostasis.
Song Y, Geng W, Zhu D, Liang H, Du Z, Tong B, Wang K, Li S, Gao Y, Feng X, Liao Z, Mei R, Yang C
Free radical biology & medicine 2024 Feb 20;212:220-233
Free radical biology & medicine 2024 Feb 20;212:220-233
MTCH2 is a mitochondrial outer membrane protein insertase.
Guna A, Stevens TA, Inglis AJ, Replogle JM, Esantsi TK, Muthukumar G, Shaffer KCL, Wang ML, Pogson AN, Jones JJ, Lomenick B, Chou TF, Weissman JS, Voorhees RM
Science (New York, N.Y.) 2022 Oct 21;378(6617):317-322
Science (New York, N.Y.) 2022 Oct 21;378(6617):317-322
ATP13A1 prevents ERAD of folding-competent mislocalized and misoriented proteins.
McKenna MJ, Adams BM, Chu V, Paulo JA, Shao S
Molecular cell 2022 Nov 17;82(22):4277-4289.e10
Molecular cell 2022 Nov 17;82(22):4277-4289.e10
Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy.
Harbauer AB, Hees JT, Wanderoy S, Segura I, Gibbs W, Cheng Y, Ordonez M, Cai Z, Cartoni R, Ashrafi G, Wang C, Perocchi F, He Z, Schwarz TL
Neuron 2022 May 4;110(9):1516-1531.e9
Neuron 2022 May 4;110(9):1516-1531.e9
Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex.
Roboti P, Lawless C, High S
Journal of cell science 2022 May 1;135(9)
Journal of cell science 2022 May 1;135(9)
Serine palmitoyltransferase assembles at ER-mitochondria contact sites.
Aaltonen MJ, Alecu I, König T, Bennett SA, Shoubridge EA
Life science alliance 2022 Feb;5(2)
Life science alliance 2022 Feb;5(2)
The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase.
McKenna MJ, Sim SI, Ordureau A, Wei L, Harper JW, Shao S, Park E
Science (New York, N.Y.) 2020 Sep 25;369(6511)
Science (New York, N.Y.) 2020 Sep 25;369(6511)
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
Jian F, Chen D, Chen L, Yan C, Lu B, Zhu Y, Chen S, Shi A, Chan DC, Song Z
Cell reports 2018 Jun 5;23(10):2989-3005
Cell reports 2018 Jun 5;23(10):2989-3005
SYNJ2BP promotes the degradation of PTEN through the lysosome-pathway and enhances breast tumor metastasis via PI3K/AKT/SNAI1 signaling.
Wang M, Wu H, Li S, Xu Z, Li X, Yang Y, Li B, Li Y, Guo J, Chen H
Oncotarget 2017 Oct 27;8(52):89692-89706
Oncotarget 2017 Oct 27;8(52):89692-89706
SYNJ2BP inhibits tumor growth and metastasis by activating DLL4 pathway in hepatocellular carcinoma.
Liu X, Zhou J, Zhou N, Zhu J, Feng Y, Miao X
Journal of experimental & clinical cancer research : CR 2016 Jul 20;35(1):115
Journal of experimental & clinical cancer research : CR 2016 Jul 20;35(1):115
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human heart tissue were subjected to SDS PAGE followed by western blot with 15666-1-AP(ARIP2; SYNJ2BP antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of MCF-7 cells, using SYNJ2BP antibody 15666-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-ARIP2; SYNJ2BP (IP:15666-1-AP, 3ug; Detection:15666-1-AP 1:500) with mouse lung tissue lysate 4000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human stomach cancer using 15666-1-AP(ARIP2; SYNJ2BP antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
