Antibody data
- Antibody Data
- Antigen structure
- References [15]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [7]
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Validation data
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- Product number
- HPA001906 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA001906, RRID:AB_1078249
- Product name
- Anti-ATRX
- Antibody type
- Polyclonal
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Antigen sequence
AAWAEYEAEKKGLTMRFNIPTGTNLPPVSFNSQTP
YIPFNLGALSAMSNQQLEDLINQGREKVVEATNSV
TAVRIQPLEDIISAVWKENMNLSEAQVQALALSRQ
ASQELDVKRREAIYNDVLTKQQMLISCVQRILMNR
R- Isotype
- IgG
- Vial size
- 100 µl
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Submitted references TERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast.
ATRX represses alternative lengthening of telomeres.
Molecular-genetic and clinical characteristics of gliomas with astrocytic appearance and total 1p19q loss in a single institutional consecutive cohort.
Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas
Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas
Benefit From Procarbazine, Lomustine, and Vincristine in Oligodendroglial Tumors Is Associated With Mutation of IDH
Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells
Clinical Neuropathology practice news 2-2014: ATRX, a new candidate biomarker in gliomas
Molecular and Morphologic Correlates of the Alternative Lengthening of Telomeres Phenotype in High-Grade Astrocytomas
The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas
Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors
Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway
Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
Altered Telomeres in Tumors with ATRX and DAXX Mutations
Yoshida M, Ogawa R, Yoshida H, Maeshima A, Kanai Y, Kinoshita T, Hiraoka N, Sekine S
British journal of cancer 2015 Oct 20;113(8):1244-8
British journal of cancer 2015 Oct 20;113(8):1244-8
ATRX represses alternative lengthening of telomeres.
Napier CE, Huschtscha LI, Harvey A, Bower K, Noble JR, Hendrickson EA, Reddel RR
Oncotarget 2015 Jun 30;6(18):16543-58
Oncotarget 2015 Jun 30;6(18):16543-58
Molecular-genetic and clinical characteristics of gliomas with astrocytic appearance and total 1p19q loss in a single institutional consecutive cohort.
Hayashi S, Sasaki H, Kimura T, Abe T, Nakamura T, Kitamura Y, Miwa T, Kameyama K, Hirose Y, Yoshida K
Oncotarget 2015 Jun 30;6(18):15871-81
Oncotarget 2015 Jun 30;6(18):15871-81
Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas
Fishbein L, Khare S, Wubbenhorst B, DeSloover D, D’Andrea K, Merrill S, Cho N, Greenberg R, Else T, Montone K, LiVolsi V, Fraker D, Daber R, Cohen D, Nathanson K
Nature Communications 2015 January;6
Nature Communications 2015 January;6
Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas
Cryan J, Haidar S, Ramkissoon L, Linda Bi W, Knoff D, Schultz N, Abedalthagafi M, Brown L, Wen P, Reardon D, Dunn I, Folkerth R, Santagata S, Lindeman N, Ligon A, Beroukhim R, Hornick J, Alexander B, Ligon K, Ramkissoon S
Oncotarget 2014 October;5(18):8083-8092
Oncotarget 2014 October;5(18):8083-8092
Benefit From Procarbazine, Lomustine, and Vincristine in Oligodendroglial Tumors Is Associated With Mutation of IDH
Cairncross J, Wang M, Jenkins R, Shaw E, Giannini C, Brachman D, Buckner J, Fink K, Souhami L, Laperriere N, Huse J, Mehta M, Curran W
Journal of Clinical Oncology 2014 March;32(8):783-790
Journal of Clinical Oncology 2014 March;32(8):783-790
Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells
Barszczyk M, Buczkowicz P, Castelo-Branco P, Mack S, Ramaswamy V, Mangerel J, Agnihotri S, Remke M, Golbourn B, Pajovic S, Elizabeth C, Yu M, Luu B, Morrison A, Adamski J, Nethery-Brokx K, Li X, Van Meter T, Dirks P, Rutka J, Taylor M, Tabori U, Hawkins C
Acta Neuropathologica 2014 December;128(6):863-877
Acta Neuropathologica 2014 December;128(6):863-877
Clinical Neuropathology practice news 2-2014: ATRX, a new candidate biomarker in gliomas
Haberler C, Wöhrer A
Clinical Neuropathology 2014 ;33(03):108-111
Clinical Neuropathology 2014 ;33(03):108-111
Molecular and Morphologic Correlates of the Alternative Lengthening of Telomeres Phenotype in High-Grade Astrocytomas
Nguyen D, Heaphy C, de Wilde R, Orr B, Odia Y, Eberhart C, Meeker A, Rodriguez F
Brain Pathology 2013 May;23(3):237-243
Brain Pathology 2013 May;23(3):237-243
The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas
Abedalthagafi M, Phillips J, Kim G, Mueller S, Haas-Kogen D, Marshall R, Croul S, Santi M, Cheng J, Zhou S, Sullivan L, Martinez-Lage M, Judkins A, Perry A
Modern Pathology 2013 June;26(11):1425-1432
Modern Pathology 2013 June;26(11):1425-1432
Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors
de Wilde R, Heaphy C, Maitra A, Meeker A, Edil B, Wolfgang C, Ellison T, Schulick R, Molenaar I, Valk G, Vriens M, Borel Rinkes I, Offerhaus G, Hruban R, Matsukuma K
Modern Pathology 2012 May;25(7):1033-1039
Modern Pathology 2012 May;25(7):1033-1039
Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway
Lovejoy C, Li W, Reisenweber S, Thongthip S, Bruno J, de Lange T, De S, Petrini J, Sung P, Jasin M, Rosenbluh J, Zwang Y, Weir B, Hatton C, Ivanova E, Macconaill L, Hanna M, Hahn W, Lue N, Reddel R, Jiao Y, Kinzler K, Vogelstein B, Papadopoulos N, Meeker A, Scott H
PLoS Genetics 2012 July;8(7)
PLoS Genetics 2012 July;8(7)
Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas
Jiao Y, Killela P, Reitman Z, Rasheed B, Heaphy C, de Wilde R, Rodriguez F, Rosemberg S, Obashinjo S, Nagahashi Marie S, Bettegowda C, Agrawal N, Lipp E, Pirozzi C, Lopez G, He Y, Friedman H, Friedman A, Riggins G, Holdhoff M, Burger P, McLendon R, Bigner D, Vogelstein B, Meeker A, Kinzler K, Papadopoulos N, Diaz, Jr. L, Yan H
Oncotarget 2012 July;3(7):709-722
Oncotarget 2012 July;3(7):709-722
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
Schwartzentruber J, Korshunov A, Liu X, Jones D, Pfaff E, Jacob K, Sturm D, Fontebasso A, Quang D, Tönjes M, Hovestadt V, Albrecht S, Kool M, Nantel A, Konermann C, Lindroth A, Jäger N, Rausch T, Ryzhova M, Korbel J, Hielscher T, Hauser P, Garami M, Klekner A, Bognar L, Ebinger M, Schuhmann M, Scheurlen W, Pekrun A, Frühwald M, Roggendorf W, Kramm C, Dürken M, Atkinson J, Lepage P, Montpetit A, Zakrzewska M, Zakrzewski K, Liberski P, Dong Z, Siegel P, Kulozik A, Zapatka M, Guha A, Malkin D, Felsberg J, Reifenberger G, von Deimling A, Ichimura K, Collins V, Witt H, Milde T, Witt O, Zhang C, Castelo-Branco P, Lichter P, Faury D, Tabori U, Plass C, Majewski J, Pfister S, Jabado N
Nature 2012 January;482(7384):226-231
Nature 2012 January;482(7384):226-231
Altered Telomeres in Tumors with ATRX and DAXX Mutations
Heaphy C, de Wilde R, Jiao Y, Klein A, Edil B, Shi C, Bettegowda C, Rodriguez F, Eberhart C, Hebbar S, Offerhaus G, McLendon R, Rasheed B, He Y, Yan H, Bigner D, Oba-Shinjo S, Marie S, Riggins G, Kinzler K, Vogelstein B, Hruban R, Maitra A, Papadopoulos N, Meeker A
Science 2011 July;333(6041):425-425
Science 2011 July;333(6041):425-425
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Enhanced validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Genetic validation
- Main image
- Experimental details
- Western blot analysis in A-549 cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-ATRX antibody. Remaining relative intensity is presented. Loading control: Anti-GAPDH.
Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Main image
- Experimental details
- Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm and nuclear bodies.
- Sample type
- HUMAN
Enhanced validation
Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Orthogonal validation
- Main image
- Experimental details
- Immunohistochemistry analysis in human cerebral cortex and liver tissues using HPA001906 antibody. Corresponding ATRX RNA-seq data are presented for the same tissues.
- Sample type
- HUMAN
Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemical staining of human glioma shows moderate to strong nuclear positivity in tumor cells.
- Sample type
- HUMAN
- Submitted by
- Atlas Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemical staining of human cerebral cortex shows moderate nuclear positivity in neurons and glial cells.
- Sample type
- HUMAN
- Submitted by
- Atlas Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemical staining of human fallopian tube shows moderate to strong nuclear positivity in glandular cells.
- Submitted by
- Atlas Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemical staining of human testis shows moderate to strong nuclear positivity in a subset of cells in seminiferous ducts and Leydig cells.
- Sample type
- HUMAN
- Submitted by
- Atlas Antibodies (provider)
- Main image
- Experimental details
- Staining of human liver shows no positivity in hepatocytes as expected.
- Sample type
- HUMAN
- Submitted by
- Atlas Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemical staining of human uterine cervix shows moderate to strong nuclear positivity in squamous epithelial cells.
- Sample type
- HUMAN