PSENEN

gene product
PEN2
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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238 antibodies from 32 providers.

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Antibody
Novus Biologicals
8 antibodies
antibodies-online
82 antibodies
GeneTex
2 antibodies
Abnova Corporation
6 antibodies
OriGene
5 antibodies
LifeSpan BioSciences, Inc.
39 antibodies
NovoPro Bioscience Inc.
1 antibody
Invitrogen Antibodies
5 antibodies
Rockland Immunochemicals, Inc.
2 antibodies
Enzo Life Sciences
1 antibody
Acris Antibodies GmbH
12 antibodies
Biorbyt
11 antibodies
Abgent
3 antibodies
ProSci
2 antibodies
Cell Signaling Technology, Inc
3 antibodies
Boster Biological Technology
1 antibody
Creative Biolabs
9 antibodies
Aviva Systems Biology
4 antibodies
Creative Diagnostics
5 antibodies
Atlas Antibodies
1 antibody
R&D Systems
1 antibody
RabMAbs
1 antibody
Abbiotec
2 antibodies
MyBioSource
4 antibodies
EMD Millipore
1 antibody
RayBiotech, Inc.
1 antibody
St John's Laboratory
1 antibody
United States Biological
4 antibodies
Sigma-Aldrich
2 antibodies
BioLegend (formerly Covance Antibody Products)
1 antibody
GenWay
2 antibodies