Antibody data

Product number
BS9188
Provider
Bioworld Technology, Inc
Product name
IRAK 2 (V235) polyclonal antibody
Provider product page
Bioworld Technology, Inc - BS9188
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 211-260 of Human IRAK-2.
Description
The interleukin-1 receptor-associated kinases (IRAKs) are important downstream signaling components of Toll-like receptors (TLRs). Four mammalian IRAKs have been found, namely IRAK-1, IRAK-2, IRAK-4, and IRAK-M, all of which share sequence homology to the Drosophila melanogaster protein kinase Pelle, and all contain a death domain (DD). The DD is used for protein-protein interactions with the DDs of other molecules, IRAK2 uses its DD to mediate its interaction with MyD88. The IRAKs have putative kinase domains, although IRAK1 has dispensable kinase activity because interleukin-1-induced NF-B activation could still be driven by a kinase-inactive mutant.Due to the absence of certain key residues within their putative kinase domains, both IRAK2 and IRAK-M are catalytically inactive.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Provider Type Product Number
- No reagents -