18976-1-AP

antibody from Proteintech Group

Targeting: SH3PXD2A FISH, KIAA0418, SH3MD1

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

18976-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#18976-1-AP, RRID:AB_10598319

Product name

SH3PXD2A antibody

Antibody type

Polyclonal

Description

KD/KO validated SH3PXD2A antibody (Cat. #18976-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Expression of non-phosphorylatable S5A-L-plastin exerts phenotypes distinct from L-plastin deficiency during podosome formation and phagocytosis.

Lin X, Krishnamoorthy P, Walker EC, Joshi H, Morley SC
Frontiers in cell and developmental biology 2023;11:1020091

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Fiber Microarchitecture in Interpenetrating Collagen-Alginate Hydrogel with Tunable Mechanical Plasticity Regulates Tumor Cell Migration.

Wei Z, Liu J, Jia Y, Lei M, Zhang S, Xi P, Ma Y, Zhang M, Ma J, Wang L, Guo H, Xu F
Advanced healthcare materials 2023 Nov;12(29):e2301586

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Starvation-inactivated MTOR triggers cell migration via a ULK1-SH3PXD2A/TKS5-MMP14 pathway in ovarian carcinoma.

Lin CY, Wu KY, Chi LM, Tang YH, Huang HJ, Lai CH, Tsai CN, Tsai CL
Autophagy 2023 Dec;19(12):3151-3168

---

An oncogenic isoform of septin 9 promotes the formation of juxtanuclear invadopodia by reducing nuclear deformability.

Okletey J, Angelis D, Jones TM, Montagna C, Spiliotis ET
Cell reports 2023 Aug 29;42(8):112893

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Tumour: Fibroblast Interactions Promote Invadopodia-Mediated Migration and Invasion in Oral Squamous Cell Carcinoma.

Kato K, Miyazawa H, Kawashiri S, Lambert DW
Journal of oncology 2022;2022:5277440

---

Gab1 regulates invadopodia and autocrine VEGF through SHP2/ERK1/2 in hilar cholangiocarcinoma cells.

Li T, Tian Y, Ren W, Chen P, Luo M, Sang H
American journal of translational research 2022;14(12):8934-8946

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The clinicopathologic significance of Tks5 expression of peritoneal mesothelial cells in gastric cancer patients.

Sugimoto A, Okuno T, Tsujio G, Sera T, Yamamoto Y, Maruo K, Kushiyama S, Nishimura S, Kuroda K, Togano S, Miki Y, Yoshii M, Tamura T, Toyokawa T, Tanaka H, Muguruma K, Ohira M, Yashiro M
PloS one 2021;16(7):e0253702

---

IKKε phosphorylates kindlin-2 to induce invadopodia formation and promote colorectal cancer metastasis.

Liu G, Bao Y, Liu C, Zhu Q, Zhao L, Lu X, Zhu Q, Lv Y, Bai F, Wen H, Sun Y, Zhu WG
Theranostics 2020;10(5):2358-2373

---

Association of lncRNA SH3PXD2A-AS1 with preeclampsia and its function in invasion and migration of placental trophoblast cells.

Chen Q, Jiang S, Liu H, Gao Y, Yang X, Ren Z, Gao Y, Xiao L, Hu H, Yu Y, Yang X, Zhong M
Cell death & disease 2020 Jul 27;11(7):583

---

Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling.

Liu SC, Hsu T, Chang YS, Chung AK, Jiang SS, OuYang CN, Yuh CH, Hsueh C, Liu YP, Tsang NM
Nature communications 2018 Nov 30;9(1):5105

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Inhibition of KLF5-Myo9b-RhoA Pathway-Mediated Podosome Formation in Macrophages Ameliorates Abdominal Aortic Aneurysm.

Ma D, Zheng B, Suzuki T, Zhang R, Jiang C, Bai D, Yin W, Yang Z, Zhang X, Hou L, Zhan H, Wen JK
Circulation research 2017 Mar 3;120(5):799-815

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The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma.

Iizuka S, Abdullah C, Buschman MD, Diaz B, Courtneidge SA
Oncotarget 2016 Nov 29;7(48):78473-78486

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The invadopodia scaffold protein Tks5 is required for the growth of human breast cancer cells in vitro and in vivo.

Blouw B, Patel M, Iizuka S, Abdullah C, You WK, Huang X, Li JL, Diaz B, Stallcup WB, Courtneidge SA
PloS one 2015;10(3):e0121003

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Src-dependent Tks5 phosphorylation regulates invadopodia-associated invasion in prostate cancer cells.

Burger KL, Learman BS, Boucherle AK, Sirintrapun SJ, Isom S, Díaz B, Courtneidge SA, Seals DF
The Prostate 2014 Feb;74(2):134-48

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

HeLa cells were subjected to SDS PAGE followed by western blot with 18976-1-AP(SH3PXD2A antibody) at dilution of 1:500

Sample type

cell line

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The SH3PXD2A antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human SH3PXD2A. This antibody recognizes human,mouse,rat antigen. The SH3PXD2A antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.

Appendix

18976-1-AP.pdf

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Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human breast cancer using 18976-1-AP(SH3PXD2A antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human breast cancer using 18976-1-AP(SH3PXD2A antibody) at dilution of 1:50 (under 40x lens)

Sample type

tissue