EVPL

This gene encodes a member of the plakin family of proteins that forms a component of desmosomes and the epidermal cornified envelope. This gene is located in the tylosis oesophageal cancer locus on chromosome 17q25, and its deletion is associated with both familial and sporadic forms of oesophageal squamous cell carcinoma. Patients suffering from the autoimmune mucocutaneous disorder, paraneoplastic pemphigus, develop antibodies against the encoded protein. [provided by RefSeq, Jul 2016]

Description

Envoplakin

Tissue specificity

Group enriched (esophagus, skin , vagina)

Subcell location

Intermediate filaments, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17 (76004502 - 76027306)

Ensembl ID

ENSG00000167880  (ver. 103.38)

Orthologs

Mouse Evpl: ENSMUSG00000034282

UniProt

Q92817

neXtProt

NX_Q92817

Human splice variants
Mouse splice variants

Protein structure