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Learn16820-1-AP
antibody from Proteintech Group
Targeting: ZC3HAV1
ARTD13, FLB6421, FLJ13288, MGC48898, PARP13, ZAP, ZC3H2, ZC3HDC2
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [30]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 16820-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16820-1-AP, RRID:AB_2728733
- Product name
- ZC3HAV1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ZC3HAV1 antibody (Cat. #16820-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references FEAR antiviral response pathway is independent of interferons and countered by poxvirus proteins.
Transcriptome regulation by PARP13 in basal and antiviral states in human cells.
ZCCHC3 is a stress granule zinc knuckle protein that strongly suppresses LINE-1 retrotransposition.
Rational attenuation of RNA viruses with zinc finger antiviral protein.
STING pathway contributes to the prognosis of hepatocellular carcinoma and identification of prognostic gene signatures correlated to tumor microenvironment.
A novel IFNbeta-induced long non-coding RNA ZAP-IT1 interrupts Zika virus replication in A549 cells.
Development and Validation of Ten-RNA Binding Protein Signature Predicts Overall Survival in Osteosarcoma.
The antiviral state has shaped the CpG composition of the vertebrate interferome to avoid self-targeting.
HIV-1 matrix-tRNA complex structure reveals basis for host control of Gag localization.
The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4/UL5 Transcripts.
Association of Zinc Finger Antiviral Protein Binding to Viral Genomic RNA with Attenuation of Replication of Echovirus 7.
Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets.
The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting.
Origin and evolution of the zinc finger antiviral protein.
Zinc Finger CCCH-Type Antiviral Protein 1 Restricts the Viral Replication by Positively Regulating Type I Interferon Response.
Porcine reproductive and respiratory syndrome virus Nsp4 cleaves ZAP to antagonize its antiviral activity.
Zinc-finger antiviral protein (ZAP) is a restriction factor for replication of modified vaccinia virus Ankara (MVA) in human cells.
CpG-Recoding in Zika Virus Genome Causes Host-Age-Dependent Attenuation of Infection With Protection Against Lethal Heterologous Challenge in Mice.
The role of ZAP and OAS3/RNAseL pathways in the attenuation of an RNA virus with elevated frequencies of CpG and UpA dinucleotides.
ZAP, a CCCH-Type Zinc Finger Protein, Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication and Interacts with Viral Nsp9.
SCAF4 and SCAF8, mRNA Anti-Terminator Proteins.
Comprehensive analysis of the BC200 ribonucleoprotein reveals a reciprocal regulatory function with CSDE1/UNR.
Inhibition of Japanese encephalitis virus infection by the host zinc-finger antiviral protein.
A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV.
CG dinucleotide suppression enables antiviral defence targeting non-self RNA.
RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination.
Zinc finger antiviral protein inhibits coxsackievirus B3 virus replication and protects against viral myocarditis.
The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition.
The Zinc-Finger Antiviral Protein ZAP Inhibits LINE and Alu Retrotransposition.
Inhibition of hepatitis B virus replication by the host zinc finger antiviral protein.
Rex EA, Seo D, Chappidi S, Pinkham C, Brito Oliveira S, Embry A, Heisler D, Liu Y, Munir M, Luger K, Alto NM, da Fonseca FG, Orchard R, Hancks DC, Gammon DB
Nature microbiology 2024 Apr;9(4):988-1006
Nature microbiology 2024 Apr;9(4):988-1006
Transcriptome regulation by PARP13 in basal and antiviral states in human cells.
Busa VF, Ando Y, Aigner S, Yee BA, Yeo GW, Leung AKL
iScience 2024 Apr 19;27(4):109251
iScience 2024 Apr 19;27(4):109251
ZCCHC3 is a stress granule zinc knuckle protein that strongly suppresses LINE-1 retrotransposition.
Goodier JL, Wan H, Soares AO, Sanchez L, Selser JM, Pereira GC, Karma S, García-Pérez JL, Kazazian HH Jr, García Cañadas MM
PLoS genetics 2023 Jul;19(7):e1010795
PLoS genetics 2023 Jul;19(7):e1010795
Rational attenuation of RNA viruses with zinc finger antiviral protein.
Gonçalves-Carneiro D, Mastrocola E, Lei X, DaSilva J, Chan YF, Bieniasz PD
Nature microbiology 2022 Oct;7(10):1558-1567
Nature microbiology 2022 Oct;7(10):1558-1567
STING pathway contributes to the prognosis of hepatocellular carcinoma and identification of prognostic gene signatures correlated to tumor microenvironment.
Pu Z, Liu J, Liu Z, Peng F, Zhu Y, Wang X, He J, Yi P, Hu X, Fan X, Chen J
Cancer cell international 2022 Oct 12;22(1):314
Cancer cell international 2022 Oct 12;22(1):314
A novel IFNbeta-induced long non-coding RNA ZAP-IT1 interrupts Zika virus replication in A549 cells.
Huang Y, Su Y, Shen L, Huo Z, Chen C, Sun T, Tian X, Li N, Yang C
Virologica Sinica 2022 Dec;37(6):904-912
Virologica Sinica 2022 Dec;37(6):904-912
Development and Validation of Ten-RNA Binding Protein Signature Predicts Overall Survival in Osteosarcoma.
Zhang J, Miao X, Wu T, Jia J, Cheng X
Frontiers in molecular biosciences 2021;8:751842
Frontiers in molecular biosciences 2021;8:751842
The antiviral state has shaped the CpG composition of the vertebrate interferome to avoid self-targeting.
Shaw AE, Rihn SJ, Mollentze N, Wickenhagen A, Stewart DG, Orton RJ, Kuchi S, Bakshi S, Collados MR, Turnbull ML, Busby J, Gu Q, Smollett K, Bamford CGG, Sugrue E, Johnson PCD, Da Silva AF, Castello A, Streicker DG, Robertson DL, Palmarini M, Wilson SJ
PLoS biology 2021 Sep;19(9):e3001352
PLoS biology 2021 Sep;19(9):e3001352
HIV-1 matrix-tRNA complex structure reveals basis for host control of Gag localization.
Bou-Nader C, Muecksch F, Brown JB, Gordon JM, York A, Peng C, Ghirlando R, Summers MF, Bieniasz PD, Zhang J
Cell host & microbe 2021 Sep 8;29(9):1421-1436.e7
Cell host & microbe 2021 Sep 8;29(9):1421-1436.e7
The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4/UL5 Transcripts.
Gonzalez-Perez AC, Stempel M, Wyler E, Urban C, Piras A, Hennig T, Ganskih S, Wei Y, Heim A, Landthaler M, Pichlmair A, Dölken L, Munschauer M, Erhard F, Brinkmann MM
mBio 2021 May 4;12(3)
mBio 2021 May 4;12(3)
Association of Zinc Finger Antiviral Protein Binding to Viral Genomic RNA with Attenuation of Replication of Echovirus 7.
Goonawardane N, Nguyen D, Simmonds P
mSphere 2021 Jan 6;6(1)
mSphere 2021 Jan 6;6(1)
Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets.
Rodriguez KM, Buch-Larsen SC, Kirby IT, Siordia IR, Hutin D, Rasmussen M, Grant DM, David LL, Matthews J, Nielsen ML, Cohen MS
eLife 2021 Jan 21;10
eLife 2021 Jan 21;10
The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting.
Zimmer MM, Kibe A, Rand U, Pekarek L, Ye L, Buck S, Smyth RP, Cicin-Sain L, Caliskan N
Nature communications 2021 Dec 10;12(1):7193
Nature communications 2021 Dec 10;12(1):7193
Origin and evolution of the zinc finger antiviral protein.
Gonçalves-Carneiro D, Takata MA, Ong H, Shilton A, Bieniasz PD
PLoS pathogens 2021 Apr;17(4):e1009545
PLoS pathogens 2021 Apr;17(4):e1009545
Zinc Finger CCCH-Type Antiviral Protein 1 Restricts the Viral Replication by Positively Regulating Type I Interferon Response.
Zhang B, Goraya MU, Chen N, Xu L, Hong Y, Zhu M, Chen JL
Frontiers in microbiology 2020;11:1912
Frontiers in microbiology 2020;11:1912
Porcine reproductive and respiratory syndrome virus Nsp4 cleaves ZAP to antagonize its antiviral activity.
Zhao Y, Song Z, Bai J, Liu X, Nauwynck H, Jiang P
Veterinary microbiology 2020 Nov;250:108863
Veterinary microbiology 2020 Nov;250:108863
Zinc-finger antiviral protein (ZAP) is a restriction factor for replication of modified vaccinia virus Ankara (MVA) in human cells.
Peng C, Wyatt LS, Glushakow-Smith SG, Lal-Nag M, Weisberg AS, Moss B
PLoS pathogens 2020 Aug;16(8):e1008845
PLoS pathogens 2020 Aug;16(8):e1008845
CpG-Recoding in Zika Virus Genome Causes Host-Age-Dependent Attenuation of Infection With Protection Against Lethal Heterologous Challenge in Mice.
Trus I, Udenze D, Berube N, Wheler C, Martel MJ, Gerdts V, Karniychuk U
Frontiers in immunology 2019;10:3077
Frontiers in immunology 2019;10:3077
The role of ZAP and OAS3/RNAseL pathways in the attenuation of an RNA virus with elevated frequencies of CpG and UpA dinucleotides.
Odon V, Fros JJ, Goonawardane N, Dietrich I, Ibrahim A, Alshaikhahmed K, Nguyen D, Simmonds P
Nucleic acids research 2019 Sep 5;47(15):8061-8083
Nucleic acids research 2019 Sep 5;47(15):8061-8083
ZAP, a CCCH-Type Zinc Finger Protein, Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication and Interacts with Viral Nsp9.
Zhao Y, Song Z, Bai J, Liu X, Nauwynck H, Jiang P
Journal of virology 2019 May 15;93(10)
Journal of virology 2019 May 15;93(10)
SCAF4 and SCAF8, mRNA Anti-Terminator Proteins.
Gregersen LH, Mitter R, Ugalde AP, Nojima T, Proudfoot NJ, Agami R, Stewart A, Svejstrup JQ
Cell 2019 Jun 13;177(7):1797-1813.e18
Cell 2019 Jun 13;177(7):1797-1813.e18
Comprehensive analysis of the BC200 ribonucleoprotein reveals a reciprocal regulatory function with CSDE1/UNR.
Booy EP, McRae EK, Ezzati P, Choi T, Gussakovsky D, McKenna SA
Nucleic acids research 2018 Nov 30;46(21):11575-11591
Nucleic acids research 2018 Nov 30;46(21):11575-11591
Inhibition of Japanese encephalitis virus infection by the host zinc-finger antiviral protein.
Chiu HP, Chiu H, Yang CF, Lee YL, Chiu FL, Kuo HC, Lin RJ, Lin YL
PLoS pathogens 2018 Jul;14(7):e1007166
PLoS pathogens 2018 Jul;14(7):e1007166
A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV.
OhAinle M, Helms L, Vermeire J, Roesch F, Humes D, Basom R, Delrow JJ, Overbaugh J, Emerman M
eLife 2018 Dec 6;7
eLife 2018 Dec 6;7
CG dinucleotide suppression enables antiviral defence targeting non-self RNA.
Takata MA, Gonçalves-Carneiro D, Zang TM, Soll SJ, York A, Blanco-Melo D, Bieniasz PD
Nature 2017 Oct 5;550(7674):124-127
Nature 2017 Oct 5;550(7674):124-127
RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination.
Choudhury NR, Heikel G, Trubitsyna M, Kubik P, Nowak JS, Webb S, Granneman S, Spanos C, Rappsilber J, Castello A, Michlewski G
BMC biology 2017 Nov 8;15(1):105
BMC biology 2017 Nov 8;15(1):105
Zinc finger antiviral protein inhibits coxsackievirus B3 virus replication and protects against viral myocarditis.
Li M, Yan K, Wei L, Yang J, Lu C, Xiong F, Zheng C, Xu W
Antiviral research 2015 Nov;123:50-61
Antiviral research 2015 Nov;123:50-61
The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition.
Goodier JL, Pereira GC, Cheung LE, Rose RJ, Kazazian HH Jr
PLoS genetics 2015 May;11(5):e1005252
PLoS genetics 2015 May;11(5):e1005252
The Zinc-Finger Antiviral Protein ZAP Inhibits LINE and Alu Retrotransposition.
Moldovan JB, Moran JV
PLoS genetics 2015 May;11(5):e1005121
PLoS genetics 2015 May;11(5):e1005121
Inhibition of hepatitis B virus replication by the host zinc finger antiviral protein.
Mao R, Nie H, Cai D, Zhang J, Liu H, Yan R, Cuconati A, Block TM, Guo JT, Guo H
PLoS pathogens 2013;9(7):e1003494
PLoS pathogens 2013;9(7):e1003494
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 16820-1-AP( ZC3HAV1 Antibody) at dilution of 1:4000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ZC3HAV1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human ZC3HAV1. This antibody recognizes human,mouse,rat antigen. The ZC3HAV1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
