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- References [28]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 14716-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14716-1-AP, RRID:AB_10640526
- Product name
- KLF6 antibody
- Antibody type
- Polyclonal
- Description
- KLF6 antibody (Cat. #14716-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references RBM3-mediated m6A modification of KLF6 promotes ACSL4-driven ferroptosis in ulcerative colitis.
Network medicine modeling of the m⁶A regulatory landscape identifies a KLF6-WTAP axis as a therapeutic target in pulmonary fibrosis.
JAM-C prevents ocular fibrosis by suppressing the TAZ/KLF6 pathway.
M1 macrophage exosomes inhibit lung adenocarcinoma growth by up-regulating KLF6 via the reduction of ALKBH5-mediated KLF6 demethylation.
SDC1(+) CAFs secreting CTGF drive tumour metastasis via FGFR3 signalling in cancers.
Exploring miR-3148's impact on Krüppel-like factor 6-driven mitophagy and apoptosis in myocardial ischemic injury.
MiRNA-24 downregulates KLF6 affecting STAT3 protein expression and phosphorylation regulating melanogenesis in cashmere goat coat.
A Preliminary Study of Effect of Melatonin on Inflammation and Hypoxia-Related Factors in a Mouse Model of Elastase-Induced Intracranial Aneurysm.
RBM15 promotes m6A methylation and stability of KLF6 mRNA to accelerate pyroptosis of retinal ganglion cells in early-stage diabetic retinopathy.
Knockdown of KLF6 ameliorates myocardial infarction by regulating autophagy via transcriptional regulation of PTTG1.
KLF6-mediated glutamine metabolism governs odontogenic differentiation and matrix mineralization of dental pulp stem cells.
Silencing KLF6 Alleviates Cigarette Smoke Extract-Induced Mitochondrial Dysfunction in Bronchial Epithelial Cells by SIRT4 Upregulation.
KLF6 silencing attenuates MCAO-induced brain injury and cognitive dysfunction via targeting ferroptosis and activating the Nrf2/HO-1 pathway.
Exploring the roles and therapeutic implications of melatonin-mediated KLF6 in the development of intracranial aneurysm.
The Krüppel-like factor 6 represses proliferation and invasion of cutaneous malignant melanoma.
Klf6 aggravates myocardial ischemia/reperfusion injury by activating Acsl4-mediated ferroptosis.
MicroRNA-22-3p Regulates the Apoptosis of Lens Epithelial Cells Through Targeting KLF6 in Diabetic Cataracts.
Exosomal miR-181d-5p Derived from Rapamycin-Conditioned MDSC Alleviated Allograft Rejection by Targeting KLF6.
Succinylation of CTBP1 mediated by KAT2A suppresses its inhibitory activity on the transcription of CDH1 to promote the progression of prostate cancer.
Revealing Potential Spinal Cord Injury Biomarkers and Immune Cell Infiltration Characteristics in Mice.
MicroRNA-124 modulates neuroinflammation in acute methanol poisoning rats via targeting Krüppel-like factor-6.
Bone marrow mesenchymal stem cell-derived extracellular vesicles containing miR-181d protect rats against renal fibrosis by inhibiting KLF6 and the NF-κB signaling pathway.
MiR-181d-5p Targets KLF6 to Improve Ischemia/Reperfusion-Induced AKI Through Effects on Renal Function, Apoptosis, and Inflammation.
Salvia miltiorrhiza bunge exerts anti-oxidative effects through inhibiting KLF10 expression in vascular smooth muscle cells exposed to high glucose.
Hotspot mutant p53-R273H inhibits KLF6 expression to promote cell migration and tumor metastasis.
Artesunate induces mitochondria-mediated apoptosis of human retinoblastoma cells by upregulating Kruppel-like factor 6.
Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes.
The Growth of SGC-7901 Tumor Xenografts Was Suppressed by Chinese Bayberry Anthocyanin Extract through Upregulating KLF6 Gene Expression.
Leng X, Wang A, Wu Y, Wang H, Chen B, Long G, Yu P
Immunology and cell biology 2026 Mar;104(3):249-264
Immunology and cell biology 2026 Mar;104(3):249-264
Network medicine modeling of the m⁶A regulatory landscape identifies a KLF6-WTAP axis as a therapeutic target in pulmonary fibrosis.
Xu C, Zhou Z, Lin Y, Zhang S, Cai S, Li B, Wang Z
Journal of translational medicine 2026 Mar 5;24(1)
Journal of translational medicine 2026 Mar 5;24(1)
JAM-C prevents ocular fibrosis by suppressing the TAZ/KLF6 pathway.
Chen M, Li W, Du Y, Zhao Y, Guo Y, Li Y, Wang X, Huang L, Zeng X, Zhang Y, Huang G, Wang S, Kuang H, Sun G, Jiang Q, Li X, Lu W
Journal of advanced research 2026 Feb;80:961-975
Journal of advanced research 2026 Feb;80:961-975
M1 macrophage exosomes inhibit lung adenocarcinoma growth by up-regulating KLF6 via the reduction of ALKBH5-mediated KLF6 demethylation.
Gou J, Jia T, Song S, He J, Zhao D
Molecular and cellular biochemistry 2026 Feb;481(2):981-993
Molecular and cellular biochemistry 2026 Feb;481(2):981-993
SDC1(+) CAFs secreting CTGF drive tumour metastasis via FGFR3 signalling in cancers.
Gao GF, Ruan ZH, Zhang SB, He S, Li YQ, Lyu JL, Liu Y, Tan XL, Wang YJ, Liu ZW, Lv GZ, Chen G, Yu JH, Wei PP, Zhao JF, Sun ZT, Zhao Z, Shi Y, Liao W, Chen SW, Zhang N, Kuang DM, Guan XY, Peng RJ, Cai MY, Yao K, Bian XW, Ding PR, Luo CL, Bei JX
Gut 2026 Feb 10;
Gut 2026 Feb 10;
Exploring miR-3148's impact on Krüppel-like factor 6-driven mitophagy and apoptosis in myocardial ischemic injury.
Huang C, Li L, Deng H, Su J, Wei Q, He Y, Xian L
CytoJournal 2025;22:19
CytoJournal 2025;22:19
MiRNA-24 downregulates KLF6 affecting STAT3 protein expression and phosphorylation regulating melanogenesis in cashmere goat coat.
Zhang B, Liu R, Zhao Y, Li X, Su H, Li S, Li J, Jiang H, Zhang Q
Animal bioscience 2025 Sep;38(9):1984-1995
Animal bioscience 2025 Sep;38(9):1984-1995
A Preliminary Study of Effect of Melatonin on Inflammation and Hypoxia-Related Factors in a Mouse Model of Elastase-Induced Intracranial Aneurysm.
NarenYa, Feng Y, Su Y, Chen L, Liu Y, Sun Z, Ma Z
Brain and behavior 2025 Mar;15(3):e70371
Brain and behavior 2025 Mar;15(3):e70371
RBM15 promotes m6A methylation and stability of KLF6 mRNA to accelerate pyroptosis of retinal ganglion cells in early-stage diabetic retinopathy.
Zhou L, Zhang C, Cheng Q, Ma M, Fan X, Han Y, Zha X, Zhang Y
Journal of molecular histology 2025 Jun 4;56(3):183
Journal of molecular histology 2025 Jun 4;56(3):183
Knockdown of KLF6 ameliorates myocardial infarction by regulating autophagy via transcriptional regulation of PTTG1.
Chen Y, Zhao Q, Wu T, Sun F, Fu W
American journal of physiology. Cell physiology 2025 Jan 1;328(1):C115-C127
American journal of physiology. Cell physiology 2025 Jan 1;328(1):C115-C127
KLF6-mediated glutamine metabolism governs odontogenic differentiation and matrix mineralization of dental pulp stem cells.
Wu W, Xu Z, Zhang Y, Zhang X, Huang X, Xie Z, Chen Z
Stem cell research & therapy 2025 Apr 15;16(1):179
Stem cell research & therapy 2025 Apr 15;16(1):179
Silencing KLF6 Alleviates Cigarette Smoke Extract-Induced Mitochondrial Dysfunction in Bronchial Epithelial Cells by SIRT4 Upregulation.
Wan M, Wang C, Cui J, Xia Q, Zhang L
International journal of chronic obstructive pulmonary disease 2024;19:815-828
International journal of chronic obstructive pulmonary disease 2024;19:815-828
KLF6 silencing attenuates MCAO-induced brain injury and cognitive dysfunction via targeting ferroptosis and activating the Nrf2/HO-1 pathway.
Qian H, Zhou S, Qian R, Li Q, Zhang J, Ding Y, Wang C
Human & experimental toxicology 2024 Jan-Dec;43:9603271241304372
Human & experimental toxicology 2024 Jan-Dec;43:9603271241304372
Exploring the roles and therapeutic implications of melatonin-mediated KLF6 in the development of intracranial aneurysm.
Liu Y, Su Y, Chen L, Li A, Ma Z
Annals of medicine 2024 Dec;56(1):2397568
Annals of medicine 2024 Dec;56(1):2397568
The Krüppel-like factor 6 represses proliferation and invasion of cutaneous malignant melanoma.
Li YY, Zheng QM, Zhang N, Zhang M
Polish journal of pathology : official journal of the Polish Society of Pathologists 2023;74(3):194-202
Polish journal of pathology : official journal of the Polish Society of Pathologists 2023;74(3):194-202
Klf6 aggravates myocardial ischemia/reperfusion injury by activating Acsl4-mediated ferroptosis.
Qiu ML, Yan W, Liu MM
The Kaohsiung journal of medical sciences 2023 Oct;39(10):989-1001
The Kaohsiung journal of medical sciences 2023 Oct;39(10):989-1001
MicroRNA-22-3p Regulates the Apoptosis of Lens Epithelial Cells Through Targeting KLF6 in Diabetic Cataracts.
Yin X, Chen L, Shen J, Bi Z, Chen C, Zhao X, Liu S, Li Y
Translational vision science & technology 2023 May 1;12(5):9
Translational vision science & technology 2023 May 1;12(5):9
Exosomal miR-181d-5p Derived from Rapamycin-Conditioned MDSC Alleviated Allograft Rejection by Targeting KLF6.
Wei C, Sun Y, Zeng F, Chen X, Ma L, Liu X, Qi X, Shi W, Gao H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(34):e2304922
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(34):e2304922
Succinylation of CTBP1 mediated by KAT2A suppresses its inhibitory activity on the transcription of CDH1 to promote the progression of prostate cancer.
Zhou J, Yan X, Liu Y, Yang J
Biochemical and biophysical research communications 2023 Apr 2;650:9-16
Biochemical and biophysical research communications 2023 Apr 2;650:9-16
Revealing Potential Spinal Cord Injury Biomarkers and Immune Cell Infiltration Characteristics in Mice.
Cao L, Li Q
Frontiers in genetics 2022;13:883810
Frontiers in genetics 2022;13:883810
MicroRNA-124 modulates neuroinflammation in acute methanol poisoning rats via targeting Krüppel-like factor-6.
Zhou S, Li J, Zhang X, Xiong W
Bioengineered 2022 May;13(5):13507-13519
Bioengineered 2022 May;13(5):13507-13519
Bone marrow mesenchymal stem cell-derived extracellular vesicles containing miR-181d protect rats against renal fibrosis by inhibiting KLF6 and the NF-κB signaling pathway.
Wang SJ, Qiu ZZ, Chen FW, Mao AL, Bai JC, Hong YJ, Zhang ZP, Zhu WA, Zhang ZW, Zhou H
Cell death & disease 2022 Jun 7;13(6):535
Cell death & disease 2022 Jun 7;13(6):535
MiR-181d-5p Targets KLF6 to Improve Ischemia/Reperfusion-Induced AKI Through Effects on Renal Function, Apoptosis, and Inflammation.
Zhang Y, Li C, Guan C, Zhou B, Wang L, Yang C, Zhen L, Dai J, Zhao L, Jiang W, Xu Y
Frontiers in physiology 2020;11:510
Frontiers in physiology 2020;11:510
Salvia miltiorrhiza bunge exerts anti-oxidative effects through inhibiting KLF10 expression in vascular smooth muscle cells exposed to high glucose.
Zhou J, Zhang L, Zheng B, Zhang L, Qin Y, Zhang X, Yang Z, Nie Z, Yang G, Yu J, Wen J
Journal of ethnopharmacology 2020 Nov 15;262:113208
Journal of ethnopharmacology 2020 Nov 15;262:113208
Hotspot mutant p53-R273H inhibits KLF6 expression to promote cell migration and tumor metastasis.
Sun S, Chen H, Sun L, Wang M, Wu X, Xiao ZJ
Cell death & disease 2020 Jul 30;11(7):595
Cell death & disease 2020 Jul 30;11(7):595
Artesunate induces mitochondria-mediated apoptosis of human retinoblastoma cells by upregulating Kruppel-like factor 6.
Yang Y, Wu N, Wu Y, Chen H, Qiu J, Qian X, Zeng J, Chiu K, Gao Q, Zhuang J
Cell death & disease 2019 Nov 13;10(11):862
Cell death & disease 2019 Nov 13;10(11):862
Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes.
Suzuki T, Kikuguchi C, Nishijima S, Nagashima T, Takahashi A, Okada M, Yamamoto T
Development (Cambridge, England) 2019 Feb 15;146(4)
Development (Cambridge, England) 2019 Feb 15;146(4)
The Growth of SGC-7901 Tumor Xenografts Was Suppressed by Chinese Bayberry Anthocyanin Extract through Upregulating KLF6 Gene Expression.
Wang Y, Zhang XN, Xie WH, Zheng YX, Cao JP, Cao PR, Chen QJ, Li X, Sun CD
Nutrients 2016 Sep 27;8(10)
Nutrients 2016 Sep 27;8(10)
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 14716-1-AP(KLF6 antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The KLF6 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human KLF6. This antibody recognizes human,mouse,rat antigen. The KLF6 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
