Antibody data
- Antibody Data
- Antigen structure
- References [25]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 11115-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11115-1-AP, RRID:AB_10896499
- Product name
- DDX3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DDX3 antibody (Cat. #11115-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references NR4A1 depletion inhibits colorectal cancer progression by promoting necroptosis via the RIG-I-like receptor pathway.
A novel stroke rehabilitation strategy and underlying stress granule regulations through inhibition of NLRP3 inflammasome activation.
Kindlin-2 enhances c-Myc translation through association with DDX3X to promote pancreatic ductal adenocarcinoma progression.
HPV E7-drived ALKBH5 promotes cervical cancer progression by modulating m6A modification of PAK5.
Altered splicing factor and alternative splicing events in a mouse model of diet- and polychlorinated biphenyl-induced liver disease.
Aluminum exposure induces central nervous system impairment via activating NLRP3-medicated pyroptosis pathway.
AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironments.
The involvement of DDX3X in compression-induced nucleus pulposus pyroptosis.
The proteome and transcriptome of stress granules and P bodies during human T lymphocyte activation.
The ototoxic drug cisplatin localises to stress granules altering their dynamics and composition.
TM4SF1-AS1 inhibits apoptosis by promoting stress granule formation in cancer cells.
Long noncoding RNA RFPL1S-202 inhibits ovarian cancer progression by downregulating the IFN-β/STAT1 signaling.
DDX3X Is Hijacked by Snakehead Vesiculovirus Phosphoprotein To Facilitate Virus Replication via Stabilization of the Phosphoprotein.
Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules.
DDX3 acts as a tumor suppressor in colorectal cancer as loss of DDX3 in advanced cancer promotes tumor progression by activating the MAPK pathway.
Overexpressed DDX3x promotes abdominal aortic aneurysm formation and activates AKT in ApoE knockout mice.
DDX3X alleviates doxorubicin-induced cardiotoxicity by regulating Wnt/β-catenin signaling pathway in an in vitro model.
Circular EZH2-encoded EZH2-92aa mediates immune evasion in glioblastoma via inhibition of surface NKG2D ligands.
DEAD-Box Helicase 3 X-Linked Promotes Metastasis by Inducing Epithelial-Mesenchymal Transition via p62/Sequestosome-1.
Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.
DDX3X deficiency alleviates LPS-induced H9c2 cardiomyocytes pyroptosis by suppressing activation of NLRP3 inflammasome.
Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development.
CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation.
Tumor-suppressive miRNA-135a inhibits breast cancer cell proliferation by targeting ELK1 and ELK3 oncogenes.
(DEAD)-box RNA helicase 3 modulates NF-κB signal pathway by controlling the phosphorylation of PP2A-C subunit.
Zhu J, Li J, Yang K, Chen Y, Wang J, He Y, Shen K, Wang K, Shi T, Chen W
Cancer letters 2024 Mar 31;585:216693
Cancer letters 2024 Mar 31;585:216693
A novel stroke rehabilitation strategy and underlying stress granule regulations through inhibition of NLRP3 inflammasome activation.
Wang Q, Kohls W, Wills M, Li F, Pang Q, Geng X, Ding Y
CNS neuroscience & therapeutics 2024 Jan;30(1):e14405
CNS neuroscience & therapeutics 2024 Jan;30(1):e14405
Kindlin-2 enhances c-Myc translation through association with DDX3X to promote pancreatic ductal adenocarcinoma progression.
Liu C, Jiang K, Ding Y, Yang A, Cai R, Bai P, Xiong M, Fu C, Quan M, Xiong Z, Deng Y, Tian R, Wu C, Sun Y
Theranostics 2023;13(13):4333-4355
Theranostics 2023;13(13):4333-4355
HPV E7-drived ALKBH5 promotes cervical cancer progression by modulating m6A modification of PAK5.
Huo FC, Zhu ZM, Du WQ, Pan YJ, Jiang X, Kang MJ, Liu BW, Mou J, Pei DS
Pharmacological research 2023 Sep;195:106863
Pharmacological research 2023 Sep;195:106863
Altered splicing factor and alternative splicing events in a mouse model of diet- and polychlorinated biphenyl-induced liver disease.
Petri BJ, Piell KM, Wahlang B, Head KZ, Rouchka EC, Park JW, Hwang JY, Banerjee M, Cave MC, Klinge CM
Environmental toxicology and pharmacology 2023 Oct;103:104260
Environmental toxicology and pharmacology 2023 Oct;103:104260
Aluminum exposure induces central nervous system impairment via activating NLRP3-medicated pyroptosis pathway.
Hao W, Zhu X, Liu Z, Song Y, Wu S, Lu X, Yang J, Jin C
Ecotoxicology and environmental safety 2023 Oct 1;264:115401
Ecotoxicology and environmental safety 2023 Oct 1;264:115401
AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironments.
Zhang W, Cao L, Yang J, Zhang S, Zhao J, Shi Z, Liao K, Wang H, Chen B, Qian Z, Xu H, Wu L, Liu H, Wang H, Ma C, Qiu Y, Ge J, Chen J, Lin Y
The Journal of clinical investigation 2023 Nov 21;134(3)
The Journal of clinical investigation 2023 Nov 21;134(3)
The involvement of DDX3X in compression-induced nucleus pulposus pyroptosis.
Chi S, Li S, Xu Z, Yang G, Song Y, Liao Z, Yang C, Wu X
Biochemical and biophysical research communications 2023 May 7;655:1-10
Biochemical and biophysical research communications 2023 May 7;655:1-10
The proteome and transcriptome of stress granules and P bodies during human T lymphocyte activation.
Curdy N, Lanvin O, Cerapio JP, Pont F, Tosolini M, Sarot E, Valle C, Saint-Laurent N, Lhuillier E, Laurent C, Fournié JJ, Franchini DM
Cell reports 2023 Mar 28;42(3):112211
Cell reports 2023 Mar 28;42(3):112211
The ototoxic drug cisplatin localises to stress granules altering their dynamics and composition.
Martin JL, Terry SJ, Gale JE, Dawson SJ
Journal of cell science 2023 Jul 15;136(14)
Journal of cell science 2023 Jul 15;136(14)
TM4SF1-AS1 inhibits apoptosis by promoting stress granule formation in cancer cells.
Kitajima H, Maruyama R, Niinuma T, Yamamoto E, Takasawa A, Takasawa K, Ishiguro K, Tsuyada A, Suzuki R, Sudo G, Kubo T, Mitsuhashi K, Idogawa M, Tange S, Toyota M, Yoshido A, Kumegawa K, Kai M, Yanagihara K, Tokino T, Osanai M, Nakase H, Suzuki H
Cell death & disease 2023 Jul 13;14(7):424
Cell death & disease 2023 Jul 13;14(7):424
Long noncoding RNA RFPL1S-202 inhibits ovarian cancer progression by downregulating the IFN-β/STAT1 signaling.
Liu S, Chen X, Huang K, Xiong X, Shi Y, Wang X, Pan X, Cong Y, Sun Y, Ge L, Xu J, Jia X
Experimental cell research 2023 Jan 15;422(2):113438
Experimental cell research 2023 Jan 15;422(2):113438
DDX3X Is Hijacked by Snakehead Vesiculovirus Phosphoprotein To Facilitate Virus Replication via Stabilization of the Phosphoprotein.
Bei C, Zhang C, Wu H, Feng H, Zhang YA, Tu J
Journal of virology 2023 Feb 28;97(2):e0003523
Journal of virology 2023 Feb 28;97(2):e0003523
Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules.
Cui Q, Bi H, Lv Z, Wu Q, Hua J, Gu B, Huo C, Tang M, Chen Y, Chen C, Chen S, Zhang X, Wu Z, Lao Z, Sheng N, Shen C, Zhang Y, Wu ZY, Jin Z, Yang P, Liu H, Li J, Bai G
Cell 2023 Feb 16;186(4):803-820.e25
Cell 2023 Feb 16;186(4):803-820.e25
DDX3 acts as a tumor suppressor in colorectal cancer as loss of DDX3 in advanced cancer promotes tumor progression by activating the MAPK pathway.
Shen L, Zhang J, Xu M, Zheng Y, Wang M, Yang S, Qin B, Li S, Dong L, Dai F
International journal of biological sciences 2022;18(10):3918-3933
International journal of biological sciences 2022;18(10):3918-3933
Overexpressed DDX3x promotes abdominal aortic aneurysm formation and activates AKT in ApoE knockout mice.
Zhou Y, Chai H, Hu Y, Liu R, Jiang H, Fan R, Chen W, Chen X, Huang F
Biochemical and biophysical research communications 2022 Dec 17;634:138-144
Biochemical and biophysical research communications 2022 Dec 17;634:138-144
DDX3X alleviates doxorubicin-induced cardiotoxicity by regulating Wnt/β-catenin signaling pathway in an in vitro model.
Feng D, Li J, Guo L, Liu J, Wang S, Ma X, Song Y, Liu J, Hao E
Journal of biochemical and molecular toxicology 2022 Aug;36(8):e23077
Journal of biochemical and molecular toxicology 2022 Aug;36(8):e23077
Circular EZH2-encoded EZH2-92aa mediates immune evasion in glioblastoma via inhibition of surface NKG2D ligands.
Zhong J, Yang X, Chen J, He K, Gao X, Wu X, Zhang M, Zhou H, Xiao F, An L, Wang X, Shi Y, Zhang N
Nature communications 2022 Aug 15;13(1):4795
Nature communications 2022 Aug 15;13(1):4795
DEAD-Box Helicase 3 X-Linked Promotes Metastasis by Inducing Epithelial-Mesenchymal Transition via p62/Sequestosome-1.
Zheng Y, Xu B, Zhao Y, Yang S, Wang S, Ma L, Dong L
Digestive diseases and sciences 2021 Nov;66(11):3893-3902
Digestive diseases and sciences 2021 Nov;66(11):3893-3902
Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.
Hao W, Hao C, Wu C, Xu Y, Wu S, Lu X, Yang J, Jin C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112591
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112591
DDX3X deficiency alleviates LPS-induced H9c2 cardiomyocytes pyroptosis by suppressing activation of NLRP3 inflammasome.
Feng D, Guo L, Liu J, Song Y, Ma X, Hu H, Liu J, Hao E
Experimental and therapeutic medicine 2021 Dec;22(6):1389
Experimental and therapeutic medicine 2021 Dec;22(6):1389
Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development.
Lennox AL, Hoye ML, Jiang R, Johnson-Kerner BL, Suit LA, Venkataramanan S, Sheehan CJ, Alsina FC, Fregeau B, Aldinger KA, Moey C, Lobach I, Afenjar A, Babovic-Vuksanovic D, Bézieau S, Blackburn PR, Bunt J, Burglen L, Campeau PM, Charles P, Chung BHY, Cogné B, Curry C, D'Agostino MD, Di Donato N, Faivre L, Héron D, Innes AM, Isidor B, Keren B, Kimball A, Klee EW, Kuentz P, Küry S, Martin-Coignard D, Mirzaa G, Mignot C, Miyake N, Matsumoto N, Fujita A, Nava C, Nizon M, Rodriguez D, Blok LS, Thauvin-Robinet C, Thevenon J, Vincent M, Ziegler A, Dobyns W, Richards LJ, Barkovich AJ, Floor SN, Silver DL, Sherr EH
Neuron 2020 May 6;106(3):404-420.e8
Neuron 2020 May 6;106(3):404-420.e8
CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation.
Cheng W, Wang S, Zhang Z, Morgens DW, Hayes LR, Lee S, Portz B, Xie Y, Nguyen BV, Haney MS, Yan S, Dong D, Coyne AN, Yang J, Xian F, Cleveland DW, Qiu Z, Rothstein JD, Shorter J, Gao FB, Bassik MC, Sun S
Neuron 2019 Dec 4;104(5):885-898.e8
Neuron 2019 Dec 4;104(5):885-898.e8
Tumor-suppressive miRNA-135a inhibits breast cancer cell proliferation by targeting ELK1 and ELK3 oncogenes.
Ahmad A, Zhang W, Wu M, Tan S, Zhu T
Genes & genomics 2018 Mar;40(3):243-251
Genes & genomics 2018 Mar;40(3):243-251
(DEAD)-box RNA helicase 3 modulates NF-κB signal pathway by controlling the phosphorylation of PP2A-C subunit.
Wang X, Wang R, Luo M, Li C, Wang HX, Huan CC, Qu YR, Liao Y, Mao X
Oncotarget 2017 May 16;8(20):33197-33213
Oncotarget 2017 May 16;8(20):33197-33213
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- C6 cells were subjected to SDS PAGE followed by western blot with 11115-1-AP(DDX3 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The DDX3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human DDX3. This antibody recognizes human,mouse,rat antigen. The DDX3 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 11115-1-AP(DDX3 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue