Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS60691 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- PODXL2 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human PODXL2
- Description
- Endoglycan, also known as podocalyxin-like 2, exists as a disulfide-dependent homodimer and belongs to the CD34 family of proteins. It is a proteoglycan modified with chondroitin sulfate chains and (with appropriate post-translational modifications) functions as an L-selectin ligand, interacting via sulfation on two tyrosine residues. Endoglycan contains a membrane proximal globular domain, a single pass transmembrane domain, a mucin-like domain and a highly acidic N-terminal with O-linked sLex structures. It is widely expressed with distribution including endothelial cells, hematopoietic precursors and leukocyte subpopulations. Endoglycan is similar to PSGL-1 in that it also exhibits catch-slip transitional bonds. These bonds help to mediate the rolling and tethering of circulating leukocytes on vascular surfaces, typically during immune surveillance and inflammation. The ligand activity of Endoglycan is dependent on sialylation and fucosylation and may mediate adhesion events.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of PODXL2 pAb at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:Raw264.7 whole cell lysate Lane3:H9C2 whole cell lysate