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- References [21]
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- Product number
- 17116-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17116-1-AP, RRID:AB_2299053
- Product name
- OMA1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated OMA1 antibody (Cat. #17116-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML.
High fat diet ameliorates mitochondrial cardiomyopathy in CHCHD10 mutant mice.
Metabolic dysfunction induced by HFD + L-NAME preferentially affects hippocampal mitochondria, impacting spatial memory in rats.
FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes.
TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria.
A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion.
Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line.
Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.
Peroxiredoxin 3 deficiency induces cardiac hypertrophy and dysfunction by impaired mitochondrial quality control.
The adenosine A(2A) receptor antagonist protects against retinal mitochondrial injury in association with an altered network of competing endogenous RNAs.
Environmental cadmium impairs blood-testis barrier via activating HRI-responsive mitochondrial stress in mice.
The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer.
Niclosamide inhibits ovarian carcinoma growth by interrupting cellular bioenergetics.
A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.
Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations.
Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1.
Nitric oxide triggers the assembly of "type II" stress granules linked to decreased cell viability.
Laminar shear stress promotes mitochondrial homeostasis in endothelial cells.
Adult-onset obesity is triggered by impaired mitochondrial gene expression.
Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury.
The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis.
Spinella JF, Chagraoui J, Moison C, Lavallée VP, Boivin I, Gracias D, Lavallée S, Carpentier GR, Beliveau F, Hébert J, Sauvageau G
Leukemia 2024 Mar;38(3):530-537
Leukemia 2024 Mar;38(3):530-537
High fat diet ameliorates mitochondrial cardiomyopathy in CHCHD10 mutant mice.
Southwell N, Manzo O, Bacman S, Zhao D, Sayles NM, Dash J, Fujita K, D'Aurelio M, Di Lorenzo A, Manfredi G, Kawamata H
EMBO molecular medicine 2024 Jun;16(6):1352-1378
EMBO molecular medicine 2024 Jun;16(6):1352-1378
Metabolic dysfunction induced by HFD + L-NAME preferentially affects hippocampal mitochondria, impacting spatial memory in rats.
Vilela WR, Ramalho LS, Bechara LRG, Cabral-Costa JV, Serna JDC, Kowaltowski AJ, Xavier GF, Ferreira JCB, de Bem AF
Journal of bioenergetics and biomembranes 2024 Apr;56(2):87-99
Journal of bioenergetics and biomembranes 2024 Apr;56(2):87-99
FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes.
Qiu J, Yue F, Zhu P, Chen J, Xu F, Zhang L, Kim KH, Snyder MM, Luo N, Xu HW, Huang F, Tao WA, Kuang S
Nature communications 2023 Oct 10;14(1):6344
Nature communications 2023 Oct 10;14(1):6344
TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria.
Akabane S, Watanabe K, Kosako H, Yamashita SI, Nishino K, Kato M, Sekine S, Kanki T, Matsuda N, Endo T, Oka T
Cell reports 2023 May 30;42(5):112454
Cell reports 2023 May 30;42(5):112454
A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion.
Mann JP, Duan X, Patel S, Tábara LC, Scurria F, Alvarez-Guaita A, Haider A, Luijten I, Page M, Protasoni M, Lim K, Virtue S, O'Rahilly S, Armstrong M, Prudent J, Semple RK, Savage DB
eLife 2023 Feb 1;12
eLife 2023 Feb 1;12
Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line.
Noguchi M, Kohno S, Pellattiero A, Machida Y, Shibata K, Shintani N, Kohno T, Gotoh N, Takahashi C, Hirao A, Scorrano L, Kasahara A
Cell death & disease 2023 Apr 5;14(4):241
Cell death & disease 2023 Apr 5;14(4):241
Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.
Sun H, Shen L, Zhang P, Lin F, Ma J, Wu Y, Yu H, Sun L
International journal of molecular sciences 2022 Oct 4;23(19)
International journal of molecular sciences 2022 Oct 4;23(19)
Peroxiredoxin 3 deficiency induces cardiac hypertrophy and dysfunction by impaired mitochondrial quality control.
Sonn SK, Song EJ, Seo S, Kim YY, Um JH, Yeo FJ, Lee DS, Jeon S, Lee MN, Jin J, Kweon HY, Kim TK, Kim S, Moon SH, Rhee SG, Chung J, Yang J, Han J, Choi EY, Lee SB, Yun J, Oh GT
Redox biology 2022 May;51:102275
Redox biology 2022 May;51:102275
The adenosine A(2A) receptor antagonist protects against retinal mitochondrial injury in association with an altered network of competing endogenous RNAs.
Fang G, Zhou Y, Zhou X, Zhou H, Ge YY, Luo S, Chen JF, Zhang L
Neuropharmacology 2022 May 1;208:108981
Neuropharmacology 2022 May 1;208:108981
Environmental cadmium impairs blood-testis barrier via activating HRI-responsive mitochondrial stress in mice.
Zhou GX, Liu WB, Dai LM, Zhu HL, Xiong YW, Li DX, Xu DX, Wang H
The Science of the total environment 2022 Mar 1;810:152247
The Science of the total environment 2022 Mar 1;810:152247
The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer.
Cheng M, Yu H, Kong Q, Wang B, Shen L, Dong D, Sun L
International journal of molecular sciences 2022 Jan 25;23(3)
International journal of molecular sciences 2022 Jan 25;23(3)
Niclosamide inhibits ovarian carcinoma growth by interrupting cellular bioenergetics.
Shangguan F, Liu Y, Ma L, Qu G, Lv Q, An J, Yang S, Lu B, Cao Q
Journal of Cancer 2020;11(12):3454-3466
Journal of Cancer 2020;11(12):3454-3466
A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.
Fessler E, Eckl EM, Schmitt S, Mancilla IA, Meyer-Bender MF, Hanf M, Philippou-Massier J, Krebs S, Zischka H, Jae LT
Nature 2020 Mar;579(7799):433-437
Nature 2020 Mar;579(7799):433-437
Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations.
Liu YT, Huang X, Nguyen D, Shammas MK, Wu BP, Dombi E, Springer DA, Poulton J, Sekine S, Narendra DP
Human molecular genetics 2020 Jun 3;29(9):1547-1567
Human molecular genetics 2020 Jun 3;29(9):1547-1567
Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1.
Sekine S, Wang C, Sideris DP, Bunker E, Zhang Z, Youle RJ
Molecular cell 2019 Mar 7;73(5):1028-1043.e5
Molecular cell 2019 Mar 7;73(5):1028-1043.e5
Nitric oxide triggers the assembly of "type II" stress granules linked to decreased cell viability.
Aulas A, Lyons SM, Fay MM, Anderson P, Ivanov P
Cell death & disease 2018 Nov 13;9(11):1129
Cell death & disease 2018 Nov 13;9(11):1129
Laminar shear stress promotes mitochondrial homeostasis in endothelial cells.
Wu LH, Chang HC, Ting PC, Wang DL
Journal of cellular physiology 2018 Jun;233(6):5058-5069
Journal of cellular physiology 2018 Jun;233(6):5058-5069
Adult-onset obesity is triggered by impaired mitochondrial gene expression.
Perks KL, Ferreira N, Richman TR, Ermer JA, Kuznetsova I, Shearwood AJ, Lee RG, Viola HM, Johnstone VPA, Matthews V, Hool LC, Rackham O, Filipovska A
Science advances 2017 Aug;3(8):e1700677
Science advances 2017 Aug;3(8):e1700677
Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury.
Baburamani AA, Hurling C, Stolp H, Sobotka K, Gressens P, Hagberg H, Thornton C
International journal of molecular sciences 2015 Sep 17;16(9):22509-26
International journal of molecular sciences 2015 Sep 17;16(9):22509-26
The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis.
Joshi S, Tolkunov D, Aviv H, Hakimi AA, Yao M, Hsieh JJ, Ganesan S, Chan CS, White E
Cell reports 2015 Dec 1;13(9):1895-908
Cell reports 2015 Dec 1;13(9):1895-908
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The OMA1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human OMA1. This antibody recognizes human, mouse, rat antigen. The OMA1 antibody has been validated for the following applications: ELISA, WB analysis.
