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- Antibody Data
- Antigen structure
- References [40]
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- Product number
- 17116-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17116-1-AP, RRID:AB_2299053
- Product name
- OMA1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated OMA1 antibody (Cat. #17116-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Targeting prohibitins activates the ISR through DELE1-HRI by impairing protein import into the mitochondrial matrix.
Dynamin-Related Protein 1-Dependent Disruption of Mitochondrial Homeostasis Drives Blue Light-Induced Epithelial-Mesenchymal Transition in Retinal Aging.
The integrated stress response suppresses PINK1-dependent mitophagy by preserving mitochondrial import efficiency.
Targeting Dio3 to enhance mitophagy and ameliorate skeletal muscle wasting in sepsis.
Hepatocyte FAM210A deficiency disrupts mitochondrial function and triggers juvenile steatosis with compensatory repair in adulthood.
ER stress-related mitochondrial protein-coding gene risk model and in vitro experiments unveil OMA1 as a novel prognostic and therapeutic biomarker for low-grade glioma.
Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway.
mTOR inhibition triggers mitochondrial fragmentation in cardiomyocytes through proteosome-dependent prohibitin degradation and OPA-1 cleavage.
Compound heterozygous mutation of AFG3L2 causes autosomal recessive spinocerebellar ataxia through mitochondrial impairment and MICU1 mediated Ca(2+) overload.
The contributory role of GSK3β in hypertension exacerbating atherosclerosis by regulating the OMA1/PGC1α pathway.
An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière's disease.
PGAM5 aggravated doxorubicin-induced cardiotoxicity by disturbing mitochondrial dynamics and exacerbating cardiomyocytes apoptosis.
Clioquinol induces mitochondrial toxicity in SH-SY5Y neuroblastoma cells by affecting the respiratory chain complex IV and OPA1 dynamin-like GTPase.
Cardiac effects of OPA1 protein promotion in a transgenic animal model.
The Novel Anticancer Aryl-Ureido Fatty Acid CTU Increases Reactive Oxygen Species Production That Impairs Mitochondrial Fusion Mechanisms and Promotes MDA-MB-231 Cell Death.
Ancestral retrovirus envelope protein ERVWE1 upregulates circ_0001810, a potential biomarker for schizophrenia, and induces neuronal mitochondrial dysfunction via activating AK2.
DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML.
High fat diet ameliorates mitochondrial cardiomyopathy in CHCHD10 mutant mice.
Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease.
Metabolic dysfunction induced by HFD + L-NAME preferentially affects hippocampal mitochondria, impacting spatial memory in rats.
FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes.
TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria.
A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion.
Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line.
Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.
Peroxiredoxin 3 deficiency induces cardiac hypertrophy and dysfunction by impaired mitochondrial quality control.
The adenosine A(2A) receptor antagonist protects against retinal mitochondrial injury in association with an altered network of competing endogenous RNAs.
Environmental cadmium impairs blood-testis barrier via activating HRI-responsive mitochondrial stress in mice.
The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer.
Niclosamide inhibits ovarian carcinoma growth by interrupting cellular bioenergetics.
A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.
Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations.
Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1.
Coenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle.
Mice harbouring a SCA28 patient mutation in AFG3L2 develop late-onset ataxia associated with enhanced mitochondrial proteotoxicity.
Nitric oxide triggers the assembly of "type II" stress granules linked to decreased cell viability.
Laminar shear stress promotes mitochondrial homeostasis in endothelial cells.
Adult-onset obesity is triggered by impaired mitochondrial gene expression.
Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury.
The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis.
Sánchez-Vera I, Cosialls AM, Maritorena-Hualde N, Schuler MH, Lavilla R, Pons G, Jae LT, Iglesias-Serret D, Gil J
Cell death and differentiation 2026 May;33(5):1081-1095
Cell death and differentiation 2026 May;33(5):1081-1095
Dynamin-Related Protein 1-Dependent Disruption of Mitochondrial Homeostasis Drives Blue Light-Induced Epithelial-Mesenchymal Transition in Retinal Aging.
Li ZY, Yang D, Huang Y, Li Y, Zhao T, Xu Y
Aging cell 2026 Feb;25(2):e70416
Aging cell 2026 Feb;25(2):e70416
The integrated stress response suppresses PINK1-dependent mitophagy by preserving mitochondrial import efficiency.
Yang M, Mo Z, Walsh K, Liu W, Irahal IN, Arnoult D, Guo X
Nature communications 2026 Apr 9;
Nature communications 2026 Apr 9;
Targeting Dio3 to enhance mitophagy and ameliorate skeletal muscle wasting in sepsis.
Wang G, Chen M, Zhang Y, Wang D, Gao T, Duan J, Lu H, Cheng M, Xu Y, Li X, Wang Y, Cao K, Yu W
Redox biology 2025 Sep;85:103751
Redox biology 2025 Sep;85:103751
Hepatocyte FAM210A deficiency disrupts mitochondrial function and triggers juvenile steatosis with compensatory repair in adulthood.
Wang Y, Chu L, Zhou Y, Jin Z, Kim K, Heiden K, Gutierrez-Monreal MA, Ren J, Li Y, Cheng Z, Basso KB, Esser KA, Ryan TE, Yue F
bioRxiv : the preprint server for biology 2025 Sep 4;
bioRxiv : the preprint server for biology 2025 Sep 4;
ER stress-related mitochondrial protein-coding gene risk model and in vitro experiments unveil OMA1 as a novel prognostic and therapeutic biomarker for low-grade glioma.
Qin C, Feng Y, Wang J, Huang W, Jiang L, Li Y
Life sciences 2025 Sep 15;377:123773
Life sciences 2025 Sep 15;377:123773
Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway.
Guo QQ, Wang SS, Jiang XY, Xie XC, Zou Y, Liu JW, Guo Y, Li YH, Liu XY, Hao S, Zhang XY, Wu XX, Lu SM, Xu HD, Guo WD, Feng YL, Wang CG, Zhang SP, Li JB, Liu C, Song XY, Finkel T, Cao L
Proceedings of the National Academy of Sciences of the United States of America 2025 Oct 7;122(40):e2502841122
Proceedings of the National Academy of Sciences of the United States of America 2025 Oct 7;122(40):e2502841122
mTOR inhibition triggers mitochondrial fragmentation in cardiomyocytes through proteosome-dependent prohibitin degradation and OPA-1 cleavage.
Verdejo HE, Parra V, Del Campo A, Vasquez-Trincado C, Gatica D, Lopez-Crisosto C, Kuzmicic J, Venegas-Zamora L, Zuñiga-Cuevas U, Troncoso MF, Troncoso R, Rothermel BA, Chiong M, Abel ED, Lavandero S
Cell communication and signaling : CCS 2025 May 31;23(1):256
Cell communication and signaling : CCS 2025 May 31;23(1):256
Compound heterozygous mutation of AFG3L2 causes autosomal recessive spinocerebellar ataxia through mitochondrial impairment and MICU1 mediated Ca(2+) overload.
Li H, Ma Q, Xue Y, Cai L, Bao L, Hong L, Zeng Y, Huang SZ, Finnell RH, Zeng F
Science China. Life sciences 2025 Feb;68(2):484-501
Science China. Life sciences 2025 Feb;68(2):484-501
The contributory role of GSK3β in hypertension exacerbating atherosclerosis by regulating the OMA1/PGC1α pathway.
Bao H, Wang C, Jin Y, Meng Q, Wu J, Liu Q, Sun H
Apoptosis : an international journal on programmed cell death 2025 Feb;30(1-2):117-130
Apoptosis : an international journal on programmed cell death 2025 Feb;30(1-2):117-130
An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière's disease.
Harhai M, Foged MM, Zarges C, Landoni JC, Chollet S, Simonelli M, Recazens E, Lisci M, Laban N, Manley S, Riemer J, Lopez-Escamez JA, Lysakowski A, Jourdain AA
Cell reports 2025 Aug 26;44(8):116069
Cell reports 2025 Aug 26;44(8):116069
PGAM5 aggravated doxorubicin-induced cardiotoxicity by disturbing mitochondrial dynamics and exacerbating cardiomyocytes apoptosis.
He W, Wang J, He W, Zeng L, Zhao R, Qiu K, Tong G, Sun Z, He P
Free radical biology & medicine 2025 Aug 1;235:95-108
Free radical biology & medicine 2025 Aug 1;235:95-108
Clioquinol induces mitochondrial toxicity in SH-SY5Y neuroblastoma cells by affecting the respiratory chain complex IV and OPA1 dynamin-like GTPase.
Katsuyama M, Arakawa N, Yaoi T, Kimura E, Matsumoto M, Iwata K, Umemura A, Yabe-Nishimura C
FEBS letters 2025 Apr;599(8):1135-1145
FEBS letters 2025 Apr;599(8):1135-1145
Cardiac effects of OPA1 protein promotion in a transgenic animal model.
Bruszt K, Horvath O, Ordog K, Toth S, Juhasz K, Vamos E, Fekete K, Gallyas F, Toth K, Halmosi R, Deres L
PloS one 2024;19(11):e0310394
PloS one 2024;19(11):e0310394
The Novel Anticancer Aryl-Ureido Fatty Acid CTU Increases Reactive Oxygen Species Production That Impairs Mitochondrial Fusion Mechanisms and Promotes MDA-MB-231 Cell Death.
Tam S, Umashankar B, Rahman MK, Choucair H, Rawling T, Murray M
International journal of molecular sciences 2024 Oct 1;25(19)
International journal of molecular sciences 2024 Oct 1;25(19)
Ancestral retrovirus envelope protein ERVWE1 upregulates circ_0001810, a potential biomarker for schizophrenia, and induces neuronal mitochondrial dysfunction via activating AK2.
Li W, Xue X, Li X, Wu X, Zhou P, Xia Y, Zhang J, Zhang M, Zhu F
Cell & bioscience 2024 Nov 14;14(1):138
Cell & bioscience 2024 Nov 14;14(1):138
DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML.
Spinella JF, Chagraoui J, Moison C, Lavallée VP, Boivin I, Gracias D, Lavallée S, Carpentier GR, Beliveau F, Hébert J, Sauvageau G
Leukemia 2024 Mar;38(3):530-537
Leukemia 2024 Mar;38(3):530-537
High fat diet ameliorates mitochondrial cardiomyopathy in CHCHD10 mutant mice.
Southwell N, Manzo O, Bacman S, Zhao D, Sayles NM, Dash J, Fujita K, D'Aurelio M, Di Lorenzo A, Manfredi G, Kawamata H
EMBO molecular medicine 2024 Jun;16(6):1352-1378
EMBO molecular medicine 2024 Jun;16(6):1352-1378
Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease.
Dong J, Chen L, Ye F, Tang J, Liu B, Lin J, Zhou PH, Lu B, Wu M, Lu JH, He JJ, Engelender S, Meng Q, Song Z, He H
Nature communications 2024 Jan 2;15(1):168
Nature communications 2024 Jan 2;15(1):168
Metabolic dysfunction induced by HFD + L-NAME preferentially affects hippocampal mitochondria, impacting spatial memory in rats.
Vilela WR, Ramalho LS, Bechara LRG, Cabral-Costa JV, Serna JDC, Kowaltowski AJ, Xavier GF, Ferreira JCB, de Bem AF
Journal of bioenergetics and biomembranes 2024 Apr;56(2):87-99
Journal of bioenergetics and biomembranes 2024 Apr;56(2):87-99
FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes.
Qiu J, Yue F, Zhu P, Chen J, Xu F, Zhang L, Kim KH, Snyder MM, Luo N, Xu HW, Huang F, Tao WA, Kuang S
Nature communications 2023 Oct 10;14(1):6344
Nature communications 2023 Oct 10;14(1):6344
TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria.
Akabane S, Watanabe K, Kosako H, Yamashita SI, Nishino K, Kato M, Sekine S, Kanki T, Matsuda N, Endo T, Oka T
Cell reports 2023 May 30;42(5):112454
Cell reports 2023 May 30;42(5):112454
A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion.
Mann JP, Duan X, Patel S, Tábara LC, Scurria F, Alvarez-Guaita A, Haider A, Luijten I, Page M, Protasoni M, Lim K, Virtue S, O'Rahilly S, Armstrong M, Prudent J, Semple RK, Savage DB
eLife 2023 Feb 1;12
eLife 2023 Feb 1;12
Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line.
Noguchi M, Kohno S, Pellattiero A, Machida Y, Shibata K, Shintani N, Kohno T, Gotoh N, Takahashi C, Hirao A, Scorrano L, Kasahara A
Cell death & disease 2023 Apr 5;14(4):241
Cell death & disease 2023 Apr 5;14(4):241
Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.
Sun H, Shen L, Zhang P, Lin F, Ma J, Wu Y, Yu H, Sun L
International journal of molecular sciences 2022 Oct 4;23(19)
International journal of molecular sciences 2022 Oct 4;23(19)
Peroxiredoxin 3 deficiency induces cardiac hypertrophy and dysfunction by impaired mitochondrial quality control.
Sonn SK, Song EJ, Seo S, Kim YY, Um JH, Yeo FJ, Lee DS, Jeon S, Lee MN, Jin J, Kweon HY, Kim TK, Kim S, Moon SH, Rhee SG, Chung J, Yang J, Han J, Choi EY, Lee SB, Yun J, Oh GT
Redox biology 2022 May;51:102275
Redox biology 2022 May;51:102275
The adenosine A(2A) receptor antagonist protects against retinal mitochondrial injury in association with an altered network of competing endogenous RNAs.
Fang G, Zhou Y, Zhou X, Zhou H, Ge YY, Luo S, Chen JF, Zhang L
Neuropharmacology 2022 May 1;208:108981
Neuropharmacology 2022 May 1;208:108981
Environmental cadmium impairs blood-testis barrier via activating HRI-responsive mitochondrial stress in mice.
Zhou GX, Liu WB, Dai LM, Zhu HL, Xiong YW, Li DX, Xu DX, Wang H
The Science of the total environment 2022 Mar 1;810:152247
The Science of the total environment 2022 Mar 1;810:152247
The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer.
Cheng M, Yu H, Kong Q, Wang B, Shen L, Dong D, Sun L
International journal of molecular sciences 2022 Jan 25;23(3)
International journal of molecular sciences 2022 Jan 25;23(3)
Niclosamide inhibits ovarian carcinoma growth by interrupting cellular bioenergetics.
Shangguan F, Liu Y, Ma L, Qu G, Lv Q, An J, Yang S, Lu B, Cao Q
Journal of Cancer 2020;11(12):3454-3466
Journal of Cancer 2020;11(12):3454-3466
A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.
Fessler E, Eckl EM, Schmitt S, Mancilla IA, Meyer-Bender MF, Hanf M, Philippou-Massier J, Krebs S, Zischka H, Jae LT
Nature 2020 Mar;579(7799):433-437
Nature 2020 Mar;579(7799):433-437
Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations.
Liu YT, Huang X, Nguyen D, Shammas MK, Wu BP, Dombi E, Springer DA, Poulton J, Sekine S, Narendra DP
Human molecular genetics 2020 Jun 3;29(9):1547-1567
Human molecular genetics 2020 Jun 3;29(9):1547-1567
Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1.
Sekine S, Wang C, Sideris DP, Bunker E, Zhang Z, Youle RJ
Molecular cell 2019 Mar 7;73(5):1028-1043.e5
Molecular cell 2019 Mar 7;73(5):1028-1043.e5
Coenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle.
Nakazawa H, Ikeda K, Shinozaki S, Yasuhara S, Yu YM, Martyn JAJ, Tompkins RG, Yorozu T, Inoue S, Kaneki M
FEBS open bio 2019 Feb;9(2):348-363
FEBS open bio 2019 Feb;9(2):348-363
Mice harbouring a SCA28 patient mutation in AFG3L2 develop late-onset ataxia associated with enhanced mitochondrial proteotoxicity.
Mancini C, Hoxha E, Iommarini L, Brussino A, Richter U, Montarolo F, Cagnoli C, Parolisi R, Gondor Morosini DI, Nicolò V, Maltecca F, Muratori L, Ronchi G, Geuna S, Arnaboldi F, Donetti E, Giorgio E, Cavalieri S, Di Gregorio E, Pozzi E, Ferrero M, Riberi E, Casari G, Altruda F, Turco E, Gasparre G, Battersby BJ, Porcelli AM, Ferrero E, Brusco A, Tempia F
Neurobiology of disease 2019 Apr;124:14-28
Neurobiology of disease 2019 Apr;124:14-28
Nitric oxide triggers the assembly of "type II" stress granules linked to decreased cell viability.
Aulas A, Lyons SM, Fay MM, Anderson P, Ivanov P
Cell death & disease 2018 Nov 13;9(11):1129
Cell death & disease 2018 Nov 13;9(11):1129
Laminar shear stress promotes mitochondrial homeostasis in endothelial cells.
Wu LH, Chang HC, Ting PC, Wang DL
Journal of cellular physiology 2018 Jun;233(6):5058-5069
Journal of cellular physiology 2018 Jun;233(6):5058-5069
Adult-onset obesity is triggered by impaired mitochondrial gene expression.
Perks KL, Ferreira N, Richman TR, Ermer JA, Kuznetsova I, Shearwood AJ, Lee RG, Viola HM, Johnstone VPA, Matthews V, Hool LC, Rackham O, Filipovska A
Science advances 2017 Aug;3(8):e1700677
Science advances 2017 Aug;3(8):e1700677
Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury.
Baburamani AA, Hurling C, Stolp H, Sobotka K, Gressens P, Hagberg H, Thornton C
International journal of molecular sciences 2015 Sep 17;16(9):22509-26
International journal of molecular sciences 2015 Sep 17;16(9):22509-26
The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis.
Joshi S, Tolkunov D, Aviv H, Hakimi AA, Yao M, Hsieh JJ, Ganesan S, Chan CS, White E
Cell reports 2015 Dec 1;13(9):1895-908
Cell reports 2015 Dec 1;13(9):1895-908
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The OMA1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human OMA1. This antibody recognizes human, mouse, rat antigen. The OMA1 antibody has been validated for the following applications: ELISA, WB analysis.
