Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [16]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 15707-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15707-1-AP, RRID:AB_2133202
- Product name
- L2HGDH antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated L2HGDH antibody (Cat. #15707-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Blockage of L2HGDH-mediated S-2HG catabolism orchestrates macrophage polarization to elicit antitumor immunity.
L-2hydroxyglutaric acid rewires amino acid metabolism in colorectal cancer via the mTOR-ATF4 axis.
Renal oncometabolite L-2-hydroxyglutarate imposes a block in kidney tubulogenesis: Evidence for an epigenetic basis for the L-2HG-induced impairment of differentiation.
Oncometabolite d-2HG alters T cell metabolism to impair CD8(+) T cell function.
MYC, mitochondrial metabolism and O-GlcNAcylation converge to modulate the activity and subcellular localization of DNA and RNA demethylases.
Metabolic remodelling during early mouse embryo development.
Urinary 2-Hydroxyglutarate Enantiomers Are Markedly Elevated in a Murine Model of Type 2 Diabetic Kidney Disease.
MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome.
Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer.
2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.
L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration.
Hypoxia Induces Production of L-2-Hydroxyglutarate.
Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress.
D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth.
L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer.
Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH mutations in glioblastoma.
Feng S, Wang D, Jin Y, Huang S, Liang T, Sun W, Du X, Zhuo L, Shan C, Zhang W, Jing T, Zhao S, Hong R, You L, Liu G, Chen L, Ye D, Li X, Yang Y
Cell reports 2024 Jun 25;43(6):114300
Cell reports 2024 Jun 25;43(6):114300
L-2hydroxyglutaric acid rewires amino acid metabolism in colorectal cancer via the mTOR-ATF4 axis.
Tabata S, Kojima Y, Sakamoto T, Igarashi K, Umetsu K, Ishikawa T, Hirayama A, Kajino-Sakamoto R, Sakamoto N, Yasumoto KI, Okano K, Suzuki Y, Yachida S, Aoki M, Soga T
Oncogene 2023 Apr;42(16):1294-1307
Oncogene 2023 Apr;42(16):1294-1307
Renal oncometabolite L-2-hydroxyglutarate imposes a block in kidney tubulogenesis: Evidence for an epigenetic basis for the L-2HG-induced impairment of differentiation.
Taub M, Mahmoudzadeh NH, Tennessen JM, Sudarshan S
Frontiers in endocrinology 2022;13:932286
Frontiers in endocrinology 2022;13:932286
Oncometabolite d-2HG alters T cell metabolism to impair CD8(+) T cell function.
Notarangelo G, Spinelli JB, Perez EM, Baker GJ, Kurmi K, Elia I, Stopka SA, Baquer G, Lin JR, Golby AJ, Joshi S, Baron HF, Drijvers JM, Georgiev P, Ringel AE, Zaganjor E, McBrayer SK, Sorger PK, Sharpe AH, Wucherpfennig KW, Santagata S, Agar NYR, Suvà ML, Haigis MC
Science (New York, N.Y.) 2022 Sep 30;377(6614):1519-1529
Science (New York, N.Y.) 2022 Sep 30;377(6614):1519-1529
MYC, mitochondrial metabolism and O-GlcNAcylation converge to modulate the activity and subcellular localization of DNA and RNA demethylases.
Lin AP, Qiu Z, Ethiraj P, Sasi B, Jaafar C, Rakheja D, Aguiar RCT
Leukemia 2022 Apr;36(4):1150-1159
Leukemia 2022 Apr;36(4):1150-1159
Metabolic remodelling during early mouse embryo development.
Zhao J, Yao K, Yu H, Zhang L, Xu Y, Chen L, Sun Z, Zhu Y, Zhang C, Qian Y, Ji S, Pan H, Zhang M, Chen J, Correia C, Weiskittel T, Lin DW, Zhao Y, Chandrasekaran S, Fu X, Zhang D, Fan HY, Xie W, Li H, Hu Z, Zhang J
Nature metabolism 2021 Oct;3(10):1372-1384
Nature metabolism 2021 Oct;3(10):1372-1384
Urinary 2-Hydroxyglutarate Enantiomers Are Markedly Elevated in a Murine Model of Type 2 Diabetic Kidney Disease.
Baek J, Pennathur S
Metabolites 2021 Jul 21;11(8)
Metabolites 2021 Jul 21;11(8)
MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome.
Qiu Z, Lin AP, Jiang S, Elkashef SM, Myers J, Srikantan S, Sasi B, Cao JZ, Godley LA, Rakheja D, Lyu Y, Zheng S, Madesh M, Shiio Y, Dahia PLM, Aguiar RCT
Cell chemical biology 2020 May 21;27(5):538-550.e7
Cell chemical biology 2020 May 21;27(5):538-550.e7
Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer.
Shelar S, Shim EH, Brinkley GJ, Kundu A, Carobbio F, Poston T, Tan J, Parekh V, Benson D, Crossman DK, Buckhaults PJ, Rakheja D, Kirkman R, Sato Y, Ogawa S, Dutta S, Velu SE, Emberley E, Pan A, Chen J, Huang T, Absher D, Becker A, Kunick C, Sudarshan S
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Dec 15;24(24):6433-6446
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Dec 15;24(24):6433-6446
2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.
Sulkowski PL, Corso CD, Robinson ND, Scanlon SE, Purshouse KR, Bai H, Liu Y, Sundaram RK, Hegan DC, Fons NR, Breuer GA, Song Y, Mishra-Gorur K, De Feyter HM, de Graaf RA, Surovtseva YV, Kachman M, Halene S, Günel M, Glazer PM, Bindra RS
Science translational medicine 2017 Feb 1;9(375)
Science translational medicine 2017 Feb 1;9(375)
L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration.
Ma S, Sun R, Jiang B, Gao J, Deng W, Liu P, He R, Cui J, Ji M, Yi W, Yang P, Wu X, Xiong Y, Qiu Z, Ye D, Guan KL
Molecular and cellular biology 2017 Apr 15;37(8)
Molecular and cellular biology 2017 Apr 15;37(8)
Hypoxia Induces Production of L-2-Hydroxyglutarate.
Intlekofer AM, Dematteo RG, Venneti S, Finley LW, Lu C, Judkins AR, Rustenburg AS, Grinaway PB, Chodera JD, Cross JR, Thompson CB
Cell metabolism 2015 Aug 4;22(2):304-11
Cell metabolism 2015 Aug 4;22(2):304-11
Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress.
Oldham WM, Clish CB, Yang Y, Loscalzo J
Cell metabolism 2015 Aug 4;22(2):291-303
Cell metabolism 2015 Aug 4;22(2):291-303
D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth.
Ma S, Jiang B, Deng W, Gu ZK, Wu FZ, Li T, Xia Y, Yang H, Ye D, Xiong Y, Guan KL
Oncotarget 2015 Apr 20;6(11):8606-20
Oncotarget 2015 Apr 20;6(11):8606-20
L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer.
Shim EH, Livi CB, Rakheja D, Tan J, Benson D, Parekh V, Kho EY, Ghosh AP, Kirkman R, Velu S, Dutta S, Chenna B, Rea SL, Mishur RJ, Li Q, Johnson-Pais TL, Guo L, Bae S, Wei S, Block K, Sudarshan S
Cancer discovery 2014 Nov;4(11):1290-8
Cancer discovery 2014 Nov;4(11):1290-8
Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH mutations in glioblastoma.
Krell D, Assoku M, Galloway M, Mulholland P, Tomlinson I, Bardella C
PloS one 2011;6(5):e19868
PloS one 2011;6(5):e19868
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse small intestine tissue were subjected to SDS PAGE followed by western blot with 15707-1-AP(L2HGDH antibody) at dilution of 1:800
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 15707-1-AP(L2HGDH antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The L2HGDH antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human L2HGDH. This antibody recognizes human,mouse,rat antigen. The L2HGDH antibody has been validated for the following applications: ELISA, WB, IHC analysis.
