11332-1-AP
antibody from Proteintech Group
Targeting: EIF2B4
DKFZP586J0119, EIF-2B, EIF2B, EIF2Bdelta
Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
Reference
Comment
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- Product number
- 11332-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11332-1-AP, RRID:AB_2277640
- Product name
- EIF2B4 antibody
- Antibody type
- Polyclonal
- Description
- EIF2B4 antibody (Cat. #11332-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The HRI branch of the integrated stress response selectively triggers mitophagy.
eIF2B conformation and assembly state regulate the integrated stress response.
Sugar phosphate activation of the stress sensor eIF2B.
Comparative Nucleotide-Dependent Interactome Analysis Reveals Shared and Differential Properties of KRas4a and KRas4b.
The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes.
Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells.
Stoichiometry of the eIF2B complex is maintained by mutual stabilization of subunits.
Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.
Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation.
Chakrabarty Y, Yang Z, Chen H, Chan DC
Molecular cell 2024 Mar 21;84(6):1090-1100.e6
Molecular cell 2024 Mar 21;84(6):1090-1100.e6
eIF2B conformation and assembly state regulate the integrated stress response.
Schoof M, Boone M, Wang L, Lawrence R, Frost A, Walter P
eLife 2021 Mar 10;10
eLife 2021 Mar 10;10
Sugar phosphate activation of the stress sensor eIF2B.
Hao Q, Heo JM, Nocek BP, Hicks KG, Stoll VS, Remarcik C, Hackett S, LeBon L, Jain R, Eaton D, Rutter J, Wong YL, Sidrauski C
Nature communications 2021 Jun 8;12(1):3440
Nature communications 2021 Jun 8;12(1):3440
Comparative Nucleotide-Dependent Interactome Analysis Reveals Shared and Differential Properties of KRas4a and KRas4b.
Zhang X, Cao J, Miller SP, Jing H, Lin H
ACS central science 2018 Jan 24;4(1):71-80
ACS central science 2018 Jan 24;4(1):71-80
The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes.
Wong YL, LeBon L, Edalji R, Lim HB, Sun C, Sidrauski C
eLife 2018 Feb 28;7
eLife 2018 Feb 28;7
Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells.
Sekine Y, Zyryanova A, Crespillo-Casado A, Amin-Wetzel N, Harding HP, Ron D
PloS one 2016;11(11):e0166278
PloS one 2016;11(11):e0166278
Stoichiometry of the eIF2B complex is maintained by mutual stabilization of subunits.
Wortham NC, Stewart JD, Harris S, Coldwell MJ, Proud CG
The Biochemical journal 2016 Mar 1;473(5):571-80
The Biochemical journal 2016 Mar 1;473(5):571-80
Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.
Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P
eLife 2015 Apr 15;4:e07314
eLife 2015 Apr 15;4:e07314
Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation.
Wortham NC, Martinez M, Gordiyenko Y, Robinson CV, Proud CG
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 May;28(5):2225-37
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 May;28(5):2225-37
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 11332-1-AP(EIF2B4 antibody) at dilution of 1:400
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The EIF2B4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human EIF2B4. This antibody recognizes human,mouse,rat antigen. The EIF2B4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.