21175-1-AP

antibody from Proteintech Group

Targeting: LRPPRC GP130, LRP130, LSFC

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

21175-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#21175-1-AP, RRID:AB_10733879

Product name

LRPPRC antibody

Antibody type

Polyclonal

Description

LRPPRC antibody (Cat. #21175-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Suppressive Genetic Interactions Between Haploinsufficient Mitochondrial Genes Encoded in the 22q11.2 Microdeletion Locus Define Brain and Cardiac Phenotypes.

Wynne M, Zlatic SA, Park AS, Crocker A, Mendez-Vazquez H, Liporace E, Gokhale A, Tower-Gilchrist C, Robinette M, Purcell RH, Bassell GJ, Werner E, Kwong JQ, Faundez V
bioRxiv : the preprint server for biology 2026 Jan 9;

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Mitochondria-located circRCP regulates redox homeostasis via stabilizing LRPPRC/SLIRP complex to promote bladder urothelial carcinoma tumorigenesis.

Zhou ZH, Wen JH, Zhang YZ, Yao K, Li ZY, Li XD, Wang YJ, Jiang LJ, Ye YL, Qin Z, Liu ZW, Zhou FJ, Chen RX, Xie D, Wei WS
Cancer letters 2026 Jan 28;638:218157

---

Prognostic and Immunologic Characteristics of Head and Neck Squamous Cell Carcinoma Based on Disulfidptosis-Related lncRNAs.

Liang S, Yang X, Wang J, Yu M, Gong ZP
Molecular biotechnology 2026 Apr;68(4):1902-1920

---

Hyperglycemia impairs cognitive function by inducing mitochondrial damage through lactylation of LRPPRC at K223.

Xu J, Hao Y, Cao J, Yang X, Gao Y, Sun X, Nie R, Zhong Q, Zhong Y, Zhong J, Zheng T
EMBO molecular medicine 2026 Apr 6;

---

Machine learning-based prediction model for lung ischemia-reperfusion injury: insights from disulfidptosis-related genes.

Zhang Y, Sun J, Lin Y, Jiang R, Dong N, Dong H, Li P, Feng J, Zhu Z, Zhang G
Frontiers in pharmacology 2025;16:1545111

---

C19orf12 inhibits mitochondrial function and enhances the antitumor effects of metformin in non-small cell lung cancer.

Liu R, Zhao M, Zhang X, Wu H, Ren L, Lv J, Liu Z, Wang Q, Yao Z
Cell reports 2025 Sep 23;44(9):116163

---

Suppression of SREBP by a transmembrane protein mutated in cardiomyopathy.

Takemoto Y, Tserendagva M, Uesugi M
The Journal of biological chemistry 2025 Oct;301(10):110644

---

Intrinsic errors in mitochondrial translation trigger a decline in cell fitness.

Bal GL, Ng KY, Berzell E, Akpinar A, Ekvik AE, Koludarova L, Naddafi S, Raths C, Vane-Tempest T, VanPortfliet JJ, O'Keefe S, Najumudeen AK, Nyman TA, Stewart JB, West AP, Battersby BJ
bioRxiv : the preprint server for biology 2025 Oct 15;

---

Machine learning analysis facilitates the identification of liver biomarkers in postmortem diagnosis of heat stroke.

Pan M, Liu H, Ma C, Dong Y, Dong H
Legal medicine (Tokyo, Japan) 2025 Nov;79:102739

---

Targeting COPA to Enhance Erdafitinib Sensitivity in FGFR-Altered Bladder Cancer.

Zhao H, Gao X, Jiang Y, Yu Y, Wang L, Sun J, Wang M, Xiong X, Huang C, Zhang H, Jiang G
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(18):e2413209

---

An RNA transmethylation pathway governs kidney nephrogenic potential.

Ramalingam H, Alvarez J, Flaten A, Cobo-Stark P, Foster N, Grilli E, Lakhia R, Aboudehen K, Carroll T, Patel V
Nature communications 2025 May 28;16(1):4930

---

Deciphering m6A signatures in hepatocellular carcinoma: Single-cell insights, immune landscape, and the protective role of IGFBP3.

Chen S, Liu J, Zhang S, Zhao L, Zhang J, Han P, Zhang Q, Liu Y, Wang F, Li J
Environmental toxicology 2025 Mar;40(3):367-383

---

Leucine-rich pentatricopeptide repeat-containing protein (LRPPRC)-stabilized lncRNA small nucleolar RNA host gene 15 (Snhg15) modulates hematopoietic injury induced by γ-ray irradiation via m(6)A modification.

Zhang S, Cheng Y, Gao Y, Xu F, Wang Y, Zhang J, Shang Y, Li D, Fan S
Molecular biomedicine 2025 Jun 25;6(1):44

---

STAT3-controlled CHI3L1/SPP1 positive feedback loop demonstrates the spatial heterogeneity and immune characteristics of glioblastoma.

Yu W, Gui S, Peng L, Luo H, Xie J, Xiao J, Yilamu Y, Sun Y, Cai S, Cheng Z, Tao Z
Developmental cell 2025 Jun 23;60(12):1751-1767.e9

---

Identification and validation of the m6A-binding protein LRPPRC to promote tumorigenesis in multiple myeloma.

Tang J, Li J, Qin S, Xiao Y, Liu J, Chen X, Zhang Y
Hematology (Amsterdam, Netherlands) 2025 Dec;30(1):2523082

---

ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution.

McKenna MJ, Kraus F, Coelho JPL, Vasandani M, Zhang J, Adams BM, Paulo JA, Harper JW, Shao S
Science advances 2025 Apr 11;11(15):eadu5091

---

Correlation of disulfidptosis and periodontitis: New insights and clinical significance.

Fan Y, Liu W, Qi L, Zhao Q, Li S, Zou H, Kong C, Li Z, Ren J, Liu Z, Wang B
Archives of oral biology 2024 Oct;166:106046

---

Comprehensive analysis of disulfidptosis-related genes reveals the effect of disulfidptosis in ulcerative colitis.

Song H, Zhang F, Bai X, Liang H, Niu J, Miao Y
Scientific reports 2024 Jul 8;14(1):15705

---

A Comprehensive Prognostic Model for Colon Adenocarcinoma Depending on Nuclear-Mitochondrial-Related Genes.

Lv L, Huang Y, Li Q, Wu Y, Zheng L
Technology in cancer research & treatment 2024 Jan-Dec;23:15330338241258570

---

Targeted therapies of inflammatory diseases with intracellularly gelated macrophages in mice and rats.

Gao C, Wang Q, Ding Y, Kwong CHT, Liu J, Xie B, Wei J, Lee SMY, Mok GSP, Wang R
Nature communications 2024 Jan 6;15(1):328

---

LRPPRC promotes glycolysis by stabilising LDHA mRNA and its knockdown plus glutamine inhibitor induces synthetic lethality via m(6) A modification in triple-negative breast cancer.

Yu Y, Deng H, Wang W, Xiao S, Zheng R, Lv L, Wang H, Chen J, Zhang B
Clinical and translational medicine 2024 Feb;14(2):e1583

---

Transcriptome-Wide N6-Methyladenosine Alternations in Pulmonary Arteries of Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats and Novel Therapeutic Targets.

Feng Y, Yu Z, Tang M, Li J, Peng B, Juaiti M, Tang Y, Liang B, Ouyang M, Liu Q, Song J
Biomedicines 2024 Feb 4;12(2)

---

Structural basis of LRPPRC-SLIRP-dependent translation by the mitoribosome.

Singh V, Moran JC, Itoh Y, Soto IC, Fontanesi F, Couvillion M, Huynen MA, Churchman LS, Barrientos A, Amunts A
Nature structural & molecular biology 2024 Dec;31(12):1838-1847

---

Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome.

Wu S, Dai X, Xia Y, Zhao Q, Zhao H, Shi Z, Yin X, Liu X, Zhang A, Yao Z, Zhang H, Li Q, Thorne RF, Zhang S, Sheng W, Hu W, Gu H
Cell reports 2024 Apr 23;43(4):114111

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An LRPPRC-HAPSTR1-PSMD14 interaction regulates tumor progression in ovarian cancer.

Li D, Wang M
Aging 2024 Apr 18;16(8):6773-6795

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Sucrose Gradient Analysis of Human Mitochondrial Ribosomes and RNA.

Ng KY, Battersby BJ
Methods in molecular biology (Clifton, N.J.) 2023;2661:101-117

---

Localization of Mitochondrial Nucleoids by Transmission Electron Microscopy Using the Transgenic Expression of the Mitochondrial Helicase Twinkle and APEX2.

Pla-Martín D, Babatz F, Schauss AC
Methods in molecular biology (Clifton, N.J.) 2023;2615:173-188

---

Comprehensive analyses of m6A RNA methylation patterns and related immune microenvironment in idiopathic pulmonary arterial hypertension.

Gao G, Chen A, Gong J, Lin W, Wu W, Mohammad Ismail Hajary S, Lian G, Luo L, Xie L
Frontiers in genetics 2023;14:1222368

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LRPPRC facilitates tumor progression and immune evasion through upregulation of m(6)A modification of PD-L1 mRNA in hepatocellular carcinoma.

Wang H, Tang A, Cui Y, Gong H, Li H
Frontiers in immunology 2023;14:1144774

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GREM1, LRPPRC and SLC39A4 as potential biomarkers of intervertebral disc degeneration: a bioinformatics analysis based on multiple microarray and single-cell sequencing data.

Zhang Z, Huo J, Ji X, Wei L, Zhang J
BMC musculoskeletal disorders 2023 Sep 12;24(1):729

---

A/(H1N1) pdm09 NS1 promotes viral replication by enhancing autophagy through hijacking the IAV negative regulatory factor LRPPRC.

Guo X, Zhang Z, Lin C, Ren H, Li Y, Zhang Y, Qu Y, Li H, Ma S, Xia H, Sun R, Zu H, Lin Y, Wang X
Autophagy 2023 May;19(5):1533-1550

---

Tetracycline-dependent inhibition of mitoribosome protein elongation in mitochondrial disease mutant cells suppresses IRE1α to promote cell survival.

Ronayne CT, Bennett CF, Perry EA, Kantorovich N, Puigserver P
bioRxiv : the preprint server for biology 2023 Mar 21;

---

QKI shuttles internal m(7)G-modified transcripts into stress granules and modulates mRNA metabolism.

Zhao Z, Qing Y, Dong L, Han L, Wu D, Li Y, Li W, Xue J, Zhou K, Sun M, Tan B, Chen Z, Shen C, Gao L, Small A, Wang K, Leung K, Zhang Z, Qin X, Deng X, Xia Q, Su R, Chen J
Cell 2023 Jul 20;186(15):3208-3226.e27

---

Deubiquitylase PSMD14 inhibits autophagy to promote ovarian cancer progression via stabilization of LRPPRC.

Zhao Z, Xu H, Wei Y, Sun L, Song Y
Biochimica et biophysica acta. Molecular basis of disease 2023 Feb;1869(2):166594

---

Tetracyclines activate mitoribosome quality control and reduce ER stress to promote cell survival.

Ronayne CT, Jackson TD, Bennett CF, Perry EA, Kantorovic N, Puigserver P
EMBO reports 2023 Dec 6;24(12):e57228

---

Oxymatrine suppresses colorectal cancer progression by inhibiting NLRP3 inflammasome activation through mitophagy induction in vitro and in vivo.

Liang L, Sun W, Wei X, Wang L, Ruan H, Zhang J, Li S, Zhao B, Li M, Cai Z, Huang J
Phytotherapy research : PTR 2023 Aug;37(8):3342-3362

---

Methylation Pattern Mediated by m(6)A Regulator and Tumor Microenvironment Invasion in Lung Adenocarcinoma.

Jiang F, Hu Y, Liu X, Wang M, Wu C
Oxidative medicine and cellular longevity 2022;2022:2930310

---

CGG repeat expansion in NOTCH2NLC causes mitochondrial dysfunction and progressive neurodegeneration in Drosophila model.

Yu J, Liufu T, Zheng Y, Xu J, Meng L, Zhang W, Yuan Y, Hong D, Charlet-Berguerand N, Wang Z, Deng J
Proceedings of the National Academy of Sciences of the United States of America 2022 Oct 11;119(41):e2208649119

---

Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA.

Sen A, Kallabis S, Gaedke F, Jüngst C, Boix J, Nüchel J, Maliphol K, Hofmann J, Schauss AC, Krüger M, Wiesner RJ, Pla-Martín D
Nature communications 2022 Nov 7;13(1):6704

---

Nonstop mRNAs generate a ground state of mitochondrial gene expression noise.

Ng KY, Lutfullahoglu Bal G, Richter U, Safronov O, Paulin L, Dunn CD, Paavilainen VO, Richer J, Newman WG, Taylor RW, Battersby BJ
Science advances 2022 Nov 16;8(46):eabq5234

---

LRPPRC inhibits autophagy and promotes foam cell formation in atherosclerosis.

Xu Z, Li X, Ding Z, Zhang Y, Peng Z, Yang X, Cao W, Du R
The FEBS journal 2022 Dec;289(23):7545-7560

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Balanced mitochondrial and cytosolic translatomes underlie the biogenesis of human respiratory complexes.

Soto I, Couvillion M, Hansen KG, McShane E, Moran JC, Barrientos A, Churchman LS
Genome biology 2022 Aug 9;23(1):170

---

Succinylation Regulators Promote Clear Cell Renal Cell Carcinoma by Immune Regulation and RNA N6-Methyladenosine Methylation.

Lu W, Che X, Qu X, Zheng C, Yang X, Bao B, Li Z, Wang D, Jin Y, Wang Y, Xiao J, Qi J, Liu Y
Frontiers in cell and developmental biology 2021;9:622198

---

Analysis of m6A-Related Signatures in the Tumor Immune Microenvironment and Identification of Clinical Prognostic Regulators in Adrenocortical Carcinoma.

Jin Y, Wang Z, He D, Zhu Y, Hu X, Gong L, Xiao M, Chen X, Cheng Y, Cao K
Frontiers in immunology 2021;12:637933

---

MgFe-LDH Nanoparticles: A Promising Leukemia Inhibitory Factor Replacement for Self-Renewal and Pluripotency Maintenance in Cultured Mouse Embryonic Stem Cells.

He X, Zhu Y, Yang L, Wang Z, Wang Z, Feng J, Wen X, Cheng L, Zhu R
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 May;8(9):2003535

---

Aptamer-SH2 superbinder-based targeted therapy for pancreatic ductal adenocarcinoma.

Liu AD, Zhou J, Bi XY, Hou GQ, Li SS, Chen Q, Xu H, Cao X
Clinical and translational medicine 2021 Mar;11(3):e337

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LRPPRC regulates redox homeostasis via the circANKHD1/FOXM1 axis to enhance bladder urothelial carcinoma tumorigenesis.

Wei WS, Wang N, Deng MH, Dong P, Liu JY, Xiang Z, Li XD, Li ZY, Liu ZH, Peng YL, Li Z, Jiang LJ, Yao K, Ye YL, Lu WH, Zhang ZL, Zhou FJ, Liu ZW, Xie D, Yu CP
Redox biology 2021 Dec;48:102201

---

A mosquito salivary protein promotes flavivirus transmission by activation of autophagy.

Sun P, Nie K, Zhu Y, Liu Y, Wu P, Liu Z, Du S, Fan H, Chen CH, Zhang R, Wang P, Cheng G
Nature communications 2020 Jan 14;11(1):260

---

Hot-water extract of ripened Pu-erh tea attenuates DSS-induced colitis through modulation of the NF-κB and HIF-1α signaling pathways in mice.

Huang Y, Qiu L, Mi X, Zhang Z, Xu D, Tao X, Xing K, Wu Q, Wei H
Food & function 2020 Apr 30;11(4):3459-3470

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LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1α-FOXO4-p21-dependent signaling axis.

Sun X, Thorne RF, Zhang XD, He M, Li J, Feng S, Liu X, Wu M
EMBO reports 2020 Apr 3;21(4):e48796

---

Toxicological exploration of peptide-based cationic liposomes in siRNA delivery.

Zhu Y, Meng Y, Zhao Y, Zhu J, Xu H, Zhang E, Shi L, Du L, Liu G, Zhang C, Xu X, Kang X, Zhen Y, Zhang S
Colloids and surfaces. B, Biointerfaces 2019 Jul 1;179:66-76

---

Cryo-EM structure of human mitochondrial trifunctional protein.

Liang K, Li N, Wang X, Dai J, Liu P, Wang C, Chen XW, Gao N, Xiao J
Proceedings of the National Academy of Sciences of the United States of America 2018 Jul 3;115(27):7039-7044

---

Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames.

Liang XH, Shen W, Sun H, Migawa MT, Vickers TA, Crooke ST
Nature biotechnology 2016 Aug;34(8):875-80

---

Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cells.

Ma Y, Yao N, Liu G, Dong L, Liu Y, Zhang M, Wang F, Wang B, Wei X, Dong H, Wang L, Ji S, Zhang J, Wang Y, Huang Y, Yu J
The EMBO journal 2015 Feb 3;34(3):361-78

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

HepG2 cells were subjected to SDS PAGE followed by western blot with 21175-1-AP(LRPPRC antibody) at dilution of 1:500

Sample type

cell line

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of HepG2 cells, using LRPPRC antibody 21175-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human heart using 21175-1-AP(LRPPRC antibody) at dilution of 1:100 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human heart using 21175-1-AP(LRPPRC antibody) at dilution of 1:100 (under 40x lens)

Sample type

tissue