12715-1-AP

antibody from Proteintech Group

Targeting: DMD BMD, DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272, MRX85

Provider product page for 12715-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [39]
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Validations
Western blot [1]

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Product number: 12715-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12715-1-AP, RRID:AB_10640422
Product name: Dystrophin antibody
Antibody type: Polyclonal
Description: KD/KO validated Dystrophin antibody (Cat. #12715-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

DMD protein structure - 12715-1-AP shown in red.

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Methylprednisolone Restores Cognitive Impairment in mdx Mice by Inhibiting NF-κB/CCL5-mediated Neuroinflammation.

Zhang X, Han Z, Wang L, Luo H, Chen H, Cheng L, Jiang L
Molecular neurobiology 2025 Nov 21;63(1):122

Characterization of Dystrophin Dp71 Expression and Interaction Partners in Embryonic Brain Development: Implications for Duchenne/Becker Muscular Dystrophy.

Fujimoto T, Mori M, Tonosaki M, Yaoi T, Nakano K, Okamura T, Itoh K
Molecular neurobiology 2025 May;62(5):6256-6272

Intramuscular Reactivity of the Modified Graphene Oxides and Their Bio-Reactivity in Aging Muscle.

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Journal of functional biomaterials 2025 Mar 25;16(4)

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Disease models & mechanisms 2025 Jun 1;18(6)

Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy.

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The Journal of biological chemistry 2025 Jul;301(7):110296

Aldehyde Oxidase 1 Deficiency Enhances Aerobic Exercise Performance by Promoting Skeletal Muscle Adaptation and Improving Mitochondrial Function.

Liu Y, Wang QQ, Huang TE, Yao M, Wang BH, Huang CP, Wang S, Lu YF, Lan XQ, Tian XL, Xiang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 31;39(14):e70815

Endurance exercise has a negative impact on the onset of SOD1-G93A ALS in female mice and affects the entire skeletal muscle-motor neuron axis.

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Frontiers in pharmacology 2024;15:1360099

Inhibition of MAT2A Impairs Skeletal Muscle Repair Function.

Xiao W, Huang TE, Zhou J, Wang B, Wang X, Zeng W, Wang Q, Lan X, Xiang Y
Biomolecules 2024 Sep 2;14(9)

AQP4 Endocytosis-Lysosome Degradation Mediated by MMP-9/β-DG Involved in Diabetes Cognitive Impairment.

Yuan Y, Peng W, Lei J, Zhao Y, Zhao B, Li Y, Wang J, Qu Q
Molecular neurobiology 2024 Oct;61(10):8438-8453

Extraction method combining saponin and trehalose useful for analyzing fragile intermolecular association.

Fujimoto T, Okamura T, Itoh K
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Transient induction of actin cytoskeletal remodeling associated with dedifferentiation, proliferation, and redifferentiation stimulates cardiac regeneration.

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Acta pharmaceutica Sinica. B 2024 Jun;14(6):2537-2553

P23H rhodopsin aggregation in the ER causes synaptic protein imbalance in rod photoreceptors.

Thompson SL, Crowder SM, Hekmatara M, Sechrest ER, Deng WT, Robichaux MA
bioRxiv : the preprint server for biology 2024 Dec 16;

Inhibitor of FTO, Rhein, Restrains the Differentiation of Myoblasts and Delays Skeletal Muscle Regeneration.

Li R, Cao Y, Wu W, Liu H, Xu S
Animals : an open access journal from MDPI 2024 Aug 22;14(16)

A highly sensitive and quantitative assay for dystrophin protein using Single Molecule Count Technology.

Ishii MN, Quinton M, Kamiguchi H
Neuromuscular disorders : NMD 2023 Oct;33(10):737-743

Extracellular vesicles derived from human ESC-MSCs target macrophage and promote anti-inflammation process, angiogenesis, and functional recovery in ACS-induced severe skeletal muscle injury.

Jiang X, Yang J, Lin Y, Liu F, Tao J, Zhang W, Xu J, Zhang M
Stem cell research & therapy 2023 Nov 14;14(1):331

Adeno-associated viral delivery of engineered tRNA-enzyme pairs into nonsense mutation mouse models.

Zheng Z, Shi N, Xia Q
STAR protocols 2023 Mar 17;4(1):101950

Dystrophin Short Product, Dp71, Interacts with AQP4 and Kir4.1 Channels in the Mouse Cerebellar Glial Cells in Contrast to Dp427 at Inhibitory Postsynapses in the Purkinje Neurons.

Fujimoto T, Stam K, Yaoi T, Nakano K, Arai T, Okamura T, Itoh K
Molecular neurobiology 2023 Jul;60(7):3664-3677

Muscle cytotoxicity and immuno-reactivity analysis of the porous carbon nanospheres fabricated by high temperature calcination.

Huang J, Jian X, Xu M, Wang H, Liao Z, Lan H, Wang L, Hu J, Yu Q, Liao H
Nanomedicine : nanotechnology, biology, and medicine 2023 Feb;48:102632

Evaluation of Cardiac Function in Young Mdx Mice Using MRI with Feature Tracking and Self-Gated Magnetic Resonance Cine Imaging.

Ueda J, Saito S
Diagnostics (Basel, Switzerland) 2023 Apr 19;13(8)

Semirational bioengineering of AAV vectors with increased potency and specificity for systemic gene therapy of muscle disorders.

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Science advances 2022 Sep 23;8(38):eabn4704

Two-dimensional speckle tracking echocardiography demonstrates improved myocardial function after intravenous infusion of bone marrow mesenchymal stem in the X-Linked muscular dystrophy mice.

Liu X, Yao S, Pan M, Cai Y, Shentu W, Cai W, Yu H
BMC cardiovascular disorders 2022 Nov 3;22(1):461

Liraglutide Improves the Angiogenic Capability of EPC and Promotes Ischemic Angiogenesis in Mice under Diabetic Conditions through an Nrf2-Dependent Mechanism.

Yan X, Su Y, Fan X, Chen H, Lu Z, Liu Z, Li Y, Yi M, Zhang G, Gu C, Wang K, Wu J, Sun D, Zhang Y, Zhang C, Dai X, Zheng C
Cells 2022 Nov 29;11(23)

Dystrophin deficiency affects human astrocyte properties and response to damage.

Lange J, Gillham O, Alkharji R, Eaton S, Ferrari G, Madej M, Flower M, Tedesco FS, Muntoni F, Ferretti P
Glia 2022 Mar;70(3):466-490

Human umbilical cord-derived mesenchymal stromal cells ameliorate aging-associated skeletal muscle atrophy and dysfunction by modulating apoptosis and mitochondrial damage in SAMP10 mice.

Piao L, Huang Z, Inoue A, Kuzuya M, Cheng XW
Stem cell research & therapy 2022 Jun 3;13(1):226

Amyloids facilitate DNA transfection in vivo.

Imamura Y, Hiyama A, Miyazaki H, Yamanaka T, Nukina N
Neuroscience research 2022 Jul;180:99-107

Embryonic stem cell-derived mesenchymal stem cells alleviate skeletal muscle injury induced by acute compartment syndrome.

Jiang X, Yang J, Liu F, Tao J, Xu J, Zhang M
Stem cell research & therapy 2022 Jul 15;13(1):313

Restoration of dystrophin expression in mice by suppressing a nonsense mutation through the incorporation of unnatural amino acids.

Shi N, Yang Q, Zhang H, Lu J, Lin H, Yang X, Abulimiti A, Cheng J, Wang Y, Tong L, Wang T, Zhang X, Chen H, Xia Q
Nature biomedical engineering 2022 Feb;6(2):195-206

Knockdown of Salusin-β Improves Cardiovascular Function in Myocardial Infarction-Induced Chronic Heart Failure Rats.

Xu Y, Pan Y, Wang X, Chen A, Tang X, Liu X, Han Y
Oxidative medicine and cellular longevity 2021;2021:8896226

Targeting the Ang2/Tie2 Axis with Tanshinone IIA Elicits Vascular Normalization in Ischemic Injury and Colon Cancer.

Zou W, Qian C, Zhang S, Wan X, Wei Z, Li X, Wu Y, Chen W, Wang A, Zhao Y, Lu Y
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FGF21 promotes ischaemic angiogenesis and endothelial progenitor cells function under diabetic conditions in an AMPK/NAD+-dependent manner.

Dai Q, Fan X, Meng X, Sun S, Su Y, Ling X, Chen X, Wang K, Dai X, Zhang C, Da S, Zhang G, Gu C, Chen H, He J, Hu H, Yu L, Pan X, Tan Y, Yan X
Journal of cellular and molecular medicine 2021 Mar;25(6):3091-3102

Protective Effects of Rocuronium Bromide on Ischemia-Reperfusion Injury in Skeletal Muscle Induced by Tourniquet in Patients Undergoing Elective Unilateral Total Knee Arthroplasty: A Prospective, Double Blind, Randomized, Controlled Study.

Chen H, Wei JQ, Wang YW, Zhou KP, He Y, Liu H, Zhang YY
Drug design, development and therapy 2020;14:3373-3384

Dystroglycan regulates proper expression, submembranous localization and subsequent phosphorylation of Dp71 through physical interaction.

Fujimoto T, Yaoi T, Tanaka H, Itoh K
Human molecular genetics 2020 Nov 25;29(19):3312-3326

The exocyst complex regulates insulin-stimulated glucose uptake of skeletal muscle cells.

Fujimoto BA, Young M, Carter L, Pang APS, Corley MJ, Fogelgren B, Polgar N
American journal of physiology. Endocrinology and metabolism 2019 Dec 1;317(6):E957-E972

New insights into meningitic Escherichia coli infection of brain microvascular endothelial cells from quantitative proteomics analysis.

Liu WT, Lv YJ, Yang RC, Fu JY, Liu L, Wang H, Cao Q, Tan C, Chen HC, Wang XR
Journal of neuroinflammation 2018 Oct 19;15(1):291

Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice.

Lu IL, Chen C, Tung CY, Chen HH, Pan JP, Chang CH, Cheng JS, Chen YA, Wang CH, Huang CW, Kang YN, Chang HY, Li LL, Chang KP, Shih YH, Lin CH, Kwan SY, Tsai JW
Nature communications 2018 Jun 27;9(1):2498

Dp71 is regulated by phosphorylation and ubiquitin-proteasome system in neuronal cells.

Fujimoto T, Yaoi T, Fushiki S, Itoh K
Biochemical and biophysical research communications 2017 Oct 21;492(3):349-355

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Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse brain tissue were subjected to SDS PAGE followed by western blot with 12715-1-AP(DMD antibody) at dilution of 1:1500
Sample type: tissue