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- Antibody Data
- Antigen structure
- References [26]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 19704-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19704-1-AP, RRID:AB_10638920
- Product name
- ND2 antibody
- Antibody type
- Polyclonal
- Description
- ND2 antibody (Cat. #19704-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Aging-induced tRNA(Glu)-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization.
TAX1BP1 contributes to deoxypodophyllotoxin-induced glioma cell parthanatos via inducing nuclear translocation of AIF by activation of mitochondrial respiratory chain complex I.
Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1.
Mitochondrial DNA breaks activate an integrated stress response to reestablish homeostasis.
Decreased expression of mitochondrial aminoacyl-tRNA synthetases causes downregulation of OXPHOS subunits in type 2 diabetic muscle.
Identification of a weight loss-associated causal eQTL in MTIF3 and the effects of MTIF3 deficiency on human adipocyte function.
A conditional knockout rat resource of mitochondrial protein-coding genes via a DdCBE-induced premature stop codon.
Aberrant RNA processing contributes to the pathogenesis of mitochondrial diseases in trans-mitochondrial mouse model carrying mitochondrial tRNALeu(UUR) with a pathogenic A2748G mutation.
DJ-1 regulates mitochondrial gene expression during ischemia and reperfusion.
Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells.
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
HIF-1-induced mitochondrial ribosome protein L52: a mechanism for breast cancer cellular adaptation and metastatic initiation in response to hypoxia.
Transcription of MRPL12 regulated by Nrf2 contributes to the mitochondrial dysfunction in diabetic kidney disease.
Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain.
MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex.
SQSTM1/p62 Controls mtDNA Expression and Participates in Mitochondrial Energetic Adaption via MRPL12.
Hypertension-associated mitochondrial DNA 4401A>G mutation caused the aberrant processing of tRNAMet, all 8 tRNAs and ND6 mRNA in the light-strand transcript.
Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3.
The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα.
CO(2)-sensitive tRNA modification associated with human mitochondrial disease.
Metabolic and chemical regulation of tRNA modification associated with taurine deficiency and human disease.
NSUN3 methylase initiates 5-formylcytidine biogenesis in human mitochondrial tRNA(Met).
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.
EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
Li D, Gao X, Ma X, Wang M, Cheng C, Xue T, Gao F, Shen Y, Zhang J, Liu Q
Cell metabolism 2024 May 7;36(5):1059-1075.e9
Cell metabolism 2024 May 7;36(5):1059-1075.e9
TAX1BP1 contributes to deoxypodophyllotoxin-induced glioma cell parthanatos via inducing nuclear translocation of AIF by activation of mitochondrial respiratory chain complex I.
Wang XZ, Liang SP, Chen X, Wang ZC, Li C, Feng CS, Lu S, He C, Wang YB, Chi GF, Ge PF
Acta pharmacologica Sinica 2023 Sep;44(9):1906-1919
Acta pharmacologica Sinica 2023 Sep;44(9):1906-1919
Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1.
Liu Y, Zhang H, Liu Y, Zhang S, Su P, Wang L, Li Y, Liang Y, Wang X, Zhao W, Chen B, Luo D, Zhang N, Yang Q
Autophagy 2023 Sep;19(9):2443-2463
Autophagy 2023 Sep;19(9):2443-2463
Mitochondrial DNA breaks activate an integrated stress response to reestablish homeostasis.
Fu Y, Sacco O, DeBitetto E, Kanshin E, Ueberheide B, Sfeir A
Molecular cell 2023 Oct 19;83(20):3740-3753.e9
Molecular cell 2023 Oct 19;83(20):3740-3753.e9
Decreased expression of mitochondrial aminoacyl-tRNA synthetases causes downregulation of OXPHOS subunits in type 2 diabetic muscle.
López-Soldado I, Torres AG, Ventura R, Martínez-Ruiz I, Díaz-Ramos A, Planet E, Cooper D, Pazderska A, Wanic K, O'Hanlon D, O'Gorman DJ, Carbonell T, Ribas de Pouplana L, Nolan JJ, Zorzano A, Hernández-Alvarez MI
Redox biology 2023 May;61:102630
Redox biology 2023 May;61:102630
Identification of a weight loss-associated causal eQTL in MTIF3 and the effects of MTIF3 deficiency on human adipocyte function.
Huang M, Coral D, Ardalani H, Spegel P, Saadat A, Claussnitzer M, Mulder H, Franks PW, Kalamajski S
eLife 2023 Mar 6;12
eLife 2023 Mar 6;12
A conditional knockout rat resource of mitochondrial protein-coding genes via a DdCBE-induced premature stop codon.
Tan L, Qi X, Kong W, Jin J, Lu D, Zhang X, Wang Y, Wang S, Dong W, Shi X, Chen W, Wang J, Li K, Xie Y, Gao L, Guan F, Gao K, Li C, Wang C, Hu Z, Zhang L, Guo X, Shen B, Ma Y
Science advances 2023 Apr 14;9(15):eadf2695
Science advances 2023 Apr 14;9(15):eadf2695
Aberrant RNA processing contributes to the pathogenesis of mitochondrial diseases in trans-mitochondrial mouse model carrying mitochondrial tRNALeu(UUR) with a pathogenic A2748G mutation.
Tani H, Ishikawa K, Tamashiro H, Ogasawara E, Yasukawa T, Matsuda S, Shimizu A, Kang D, Hayashi JI, Wei FY, Nakada K
Nucleic acids research 2022 Sep 9;50(16):9382-9396
Nucleic acids research 2022 Sep 9;50(16):9382-9396
DJ-1 regulates mitochondrial gene expression during ischemia and reperfusion.
Gallinat A, Rakovic A, Klein C, Badimon L
Free radical biology & medicine 2022 Nov 20;193(Pt 1):430-436
Free radical biology & medicine 2022 Nov 20;193(Pt 1):430-436
Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.
Jiang B, Zhang J, Zhao G, Liu M, Hu J, Lin F, Wang J, Zhao W, Ma H, Zhang C, Wu C, Yao L, Liu Q, Chen X, Cao Y, Zheng Y, Zhang C, Han A, Lin D, Li Q
Molecular cell 2022 May 19;82(10):1821-1835.e6
Molecular cell 2022 May 19;82(10):1821-1835.e6
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
Shu Y, Hao Y, Feng J, Liu H, Li ST, Feng J, Jiang Z, Ye L, Zhou Y, Sun Y, Zhou Z, Wei H, Gao P, Zhang H, Sun L
The EMBO journal 2022 Dec 1;41(23):e111550
The EMBO journal 2022 Dec 1;41(23):e111550
ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells.
Yang Y, Li C, Gu X, Zhen J, Zhu S, Lv T, Wan Q, Liu Y
Frontiers in cell and developmental biology 2021;9:700195
Frontiers in cell and developmental biology 2021;9:700195
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
Sun D, Niu Z, Zheng HX, Wu F, Jiang L, Han TQ, Wei Y, Wang J, Jin L
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15
HIF-1-induced mitochondrial ribosome protein L52: a mechanism for breast cancer cellular adaptation and metastatic initiation in response to hypoxia.
Li X, Wang M, Li S, Chen Y, Wang M, Wu Z, Sun X, Yao L, Dong H, Song Y, Xu Y
Theranostics 2021;11(15):7337-7359
Theranostics 2021;11(15):7337-7359
Transcription of MRPL12 regulated by Nrf2 contributes to the mitochondrial dysfunction in diabetic kidney disease.
Gu X, Liu Y, Wang N, Zhen J, Zhang B, Hou S, Cui Z, Wan Q, Feng H
Free radical biology & medicine 2021 Feb 20;164:329-340
Free radical biology & medicine 2021 Feb 20;164:329-340
Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain.
Zhuang X, Chen Y, Wu Z, Xu Q, Chen M, Shao M, Cao X, Zhou Y, Xie M, Shi Y, Zeng Y, Bu H
Carcinogenesis 2020 Jul 14;41(7):972-983
Carcinogenesis 2020 Jul 14;41(7):972-983
MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex.
Wang C, Richter-Dennerlein R, Pacheu-Grau D, Liu F, Zhu Y, Dennerlein S, Rehling P
EMBO reports 2020 Jan 7;21(1):e48833
EMBO reports 2020 Jan 7;21(1):e48833
SQSTM1/p62 Controls mtDNA Expression and Participates in Mitochondrial Energetic Adaption via MRPL12.
Ma Y, Zhu S, Lv T, Gu X, Feng H, Zhen J, Xin W, Wan Q
iScience 2020 Aug 21;23(8):101428
iScience 2020 Aug 21;23(8):101428
Hypertension-associated mitochondrial DNA 4401A>G mutation caused the aberrant processing of tRNAMet, all 8 tRNAs and ND6 mRNA in the light-strand transcript.
Zhao X, Cui L, Xiao Y, Mao Q, Aishanjiang M, Kong W, Liu Y, Chen H, Hong F, Jia Z, Wang M, Jiang P, Guan MX
Nucleic acids research 2019 Nov 4;47(19):10340-10356
Nucleic acids research 2019 Nov 4;47(19):10340-10356
Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3.
Fu R, Yang P, Li Z, Liu W, Amin S, Li Z
Cell death & disease 2019 Aug 7;10(8):593
Cell death & disease 2019 Aug 7;10(8):593
The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα.
Iershov A, Nemazanyy I, Alkhoury C, Girard M, Barth E, Cagnard N, Montagner A, Chretien D, Rugarli EI, Guillou H, Pende M, Panasyuk G
Nature communications 2019 Apr 5;10(1):1566
Nature communications 2019 Apr 5;10(1):1566
CO(2)-sensitive tRNA modification associated with human mitochondrial disease.
Lin H, Miyauchi K, Harada T, Okita R, Takeshita E, Komaki H, Fujioka K, Yagasaki H, Goto YI, Yanaka K, Nakagawa S, Sakaguchi Y, Suzuki T
Nature communications 2018 May 14;9(1):1875
Nature communications 2018 May 14;9(1):1875
Metabolic and chemical regulation of tRNA modification associated with taurine deficiency and human disease.
Asano K, Suzuki T, Saito A, Wei FY, Ikeuchi Y, Numata T, Tanaka R, Yamane Y, Yamamoto T, Goto T, Kishita Y, Murayama K, Ohtake A, Okazaki Y, Tomizawa K, Sakaguchi Y, Suzuki T
Nucleic acids research 2018 Feb 28;46(4):1565-1583
Nucleic acids research 2018 Feb 28;46(4):1565-1583
NSUN3 methylase initiates 5-formylcytidine biogenesis in human mitochondrial tRNA(Met).
Nakano S, Suzuki T, Kawarada L, Iwata H, Asano K, Suzuki T
Nature chemical biology 2016 Jul;12(7):546-51
Nature chemical biology 2016 Jul;12(7):546-51
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.
Wang W, Wang L, Lu J, Siedlak SL, Fujioka H, Liang J, Jiang S, Ma X, Jiang Z, da Rocha EL, Sheng M, Choi H, Lerou PH, Li H, Wang X
Nature medicine 2016 Aug;22(8):869-78
Nature medicine 2016 Aug;22(8):869-78
EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
Zhang J, Wang C, Chen X, Takada M, Fan C, Zheng X, Wen H, Liu Y, Wang C, Pestell RG, Aird KM, Kaelin WG Jr, Liu XS, Zhang Q
The EMBO journal 2015 Dec 2;34(23):2953-70
The EMBO journal 2015 Dec 2;34(23):2953-70
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 19704-1-AP(ND2 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 19704-1-AP(ND2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ND2 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human ND2. This antibody recognizes human, mouse antigen. The ND2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
