Antibody data
- Antibody Data
- Antigen structure
- References [18]
- Comments [0]
- Validations [0]
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- Product number
- HPA002847 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA002847, RRID:AB_1080107
- Product name
- Anti-CDKL5
- Antibody type
- Polyclonal
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Antigen sequence
AARANSLQLLSPQPGEQLPPEMTVARSSVKETSRE
GTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYN
DPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLP
SESSSGTNHSKRQPAFDP- Isotype
- IgG
- Vial size
- 100 µl
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Submitted references Cell type-specific expression, regulation and compensation of CDKL5 activity in mouse brain
Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorder
A new knockin mouse carrying the E364X patient mutation for CDKL5 deficiency disorder: neurological, behavioral and molecular profiling
Epilepsy-Related CDKL5 Deficiency Slows Synaptic Vesicle Endocytosis in Central Nerve Terminals
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective
Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability
Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology
Loss of CDKL5 Causes Synaptic GABAergic Defects That Can Be Restored with the Neuroactive Steroid Pregnenolone-Methyl-Ether
Phenotypic characterization of Cdkl5-knockdown neurons establishes elongated cilia as a functional assay for CDKL5 Deficiency Disorder
Cyclin-dependent–like kinase 5 is required for pain signaling in human sensory neurons and mouse models
Splicing Mutations Impairing CDKL5 Expression and Activity Can be Efficiently Rescued by U1snRNA-Based Therapy
Aminoglycoside drugs induce efficient read-through ofCDKL5nonsense mutations, slightly restoring its kinase activity
Chemical genetic identification of CDKL 5 substrates reveals its role in neuronal microtubule dynamics
CDKL5 localizes at the centrosome and midbody and is required for faithful cell division
CDKL5 and Shootin1 Interact and Concur in Regulating Neuronal Polarization
Synaptic Synthesis, Dephosphorylation, and Degradation
CDKL5 ensures excitatory synapse stability by reinforcing NGL-1–PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons
Silvestre M, Dempster K, Mihaylov S, Claxton S, Ultanir S
Molecular Psychiatry 2024;29(6):1844-1856
Molecular Psychiatry 2024;29(6):1844-1856
Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorder
Simões de Oliveira L, O’Leary H, Nawaz S, Loureiro R, Davenport E, Baxter P, Louros S, Dando O, Perkins E, Peltier J, Trost M, Osterweil E, Hardingham G, Cousin M, Chattarji S, Booker S, Benke T, Wyllie D, Kind P
Molecular Autism 2024;15(1)
Molecular Autism 2024;15(1)
A new knockin mouse carrying the E364X patient mutation for CDKL5 deficiency disorder: neurological, behavioral and molecular profiling
Quadalti C, Sannia M, Humphreys N, Baldassarro V, Gurgone A, Ascolani M, Zanella L, Giardino L, Gross C, Croci S, Meloni I, Giustetto M, Renieri A, Lorenzini L, Calzà L
Heliyon 2024;10(21):e40165
Heliyon 2024;10(21):e40165
Epilepsy-Related CDKL5 Deficiency Slows Synaptic Vesicle Endocytosis in Central Nerve Terminals
Kontaxi C, Ivanova D, Davenport E, Kind P, Cousin M
The Journal of Neuroscience 2023;43(11):2002-2020
The Journal of Neuroscience 2023;43(11):2002-2020
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective
Ong H, Liang Y, Richardson W, Lowry E, Wells C, Chen X, Silvestre M, Dempster K, Silvaroli J, Smith J, Wichterle H, Pabla N, Ultanir S, Bullock A, Drewry D, Axtman A
ACS Chemical Neuroscience 2023;14(9):1672-1685
ACS Chemical Neuroscience 2023;14(9):1672-1685
Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability
Sampedro-Castañeda M, Baltussen L, Lopes A, Qiu Y, Sirvio L, Mihaylov S, Claxton S, Richardson J, Lignani G, Ultanir S
Nature Communications 2023;14(1)
Nature Communications 2023;14(1)
Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology
Silvestre M, Castano A, Wells C, Sanderson J, Ferrer C, Ong H, Lang Y, Richardson W, Silvaroli J, Bashore F, Smith J, Genereux I, Dempster K, Drewry D, Pabla N, Bullock A, Benke T, Ultanir S, Axtman A
eLife 2023;12
eLife 2023;12
Ong H, Liang Y, Richardson W, Lowry E, Wells C, Chen X, Silvestre M, Dempster K, Silvaroli J, Smith J, Wichterle H, Pabla N, Ultanir S, Bullock A, Drewry D, Axtman A
2023
2023
Loss of CDKL5 Causes Synaptic GABAergic Defects That Can Be Restored with the Neuroactive Steroid Pregnenolone-Methyl-Ether
De Rosa R, Valastro S, Cambria C, Barbiero I, Puricelli C, Tramarin M, Randi S, Bianchi M, Antonucci F, Kilstrup-Nielsen C
International Journal of Molecular Sciences 2022;24(1):68
International Journal of Molecular Sciences 2022;24(1):68
Phenotypic characterization of Cdkl5-knockdown neurons establishes elongated cilia as a functional assay for CDKL5 Deficiency Disorder
Di Nardo A, Rühmkorf A, Award P, Brennecke A, Fagiolini M, Sahin M
Neuroscience Research 2022;176
Neuroscience Research 2022;176
Cyclin-dependent–like kinase 5 is required for pain signaling in human sensory neurons and mouse models
La Montanara P, Hervera A, Baltussen L, Hutson T, Palmisano I, De Virgiliis F, Kong G, Chadwick J, Gao Y, Bartus K, Majid Q, Gorgoraptis N, Wong K, Downs J, Pizzorusso T, Ultanir S, Leonard H, Yu H, Millar D, Istvan N, Mazarakis N, Di Giovanni S
Science Translational Medicine 2020;12(551)
Science Translational Medicine 2020;12(551)
Splicing Mutations Impairing CDKL5 Expression and Activity Can be Efficiently Rescued by U1snRNA-Based Therapy
Balestra D, Giorgio D, Bizzotto M, Fazzari M, Ben Zeev B, Pinotti M, Landsberger N, Frasca A
International Journal of Molecular Sciences 2019;20(17):4130
International Journal of Molecular Sciences 2019;20(17):4130
Aminoglycoside drugs induce efficient read-through ofCDKL5nonsense mutations, slightly restoring its kinase activity
Fazzari M, Frasca A, Bifari F, Landsberger N
RNA Biology 2019;16(10):1414-1423
RNA Biology 2019;16(10):1414-1423
Chemical genetic identification of CDKL 5 substrates reveals its role in neuronal microtubule dynamics
Baltussen L, Negraes P, Silvestre M, Claxton S, Moeskops M, Christodoulou E, Flynn H, Snijders A, Muotri A, Ultanir S
The EMBO Journal 2018;37(24)
The EMBO Journal 2018;37(24)
CDKL5 localizes at the centrosome and midbody and is required for faithful cell division
Barbiero I, Valente D, Chandola C, Magi F, Bergo A, Monteonofrio L, Tramarin M, Fazzari M, Soddu S, Landsberger N, Rinaldo C, Kilstrup-Nielsen C
Scientific Reports 2017;7(1)
Scientific Reports 2017;7(1)
CDKL5 and Shootin1 Interact and Concur in Regulating Neuronal Polarization
Blum R, Nawaz M, Giarda E, Bedogni F, La Montanara P, Ricciardi S, Ciceri D, Alberio T, Landsberger N, Rusconi L, Kilstrup-Nielsen C
PLOS ONE 2016;11(2):e0148634
PLOS ONE 2016;11(2):e0148634
Synaptic Synthesis, Dephosphorylation, and Degradation
La Montanara P, Rusconi L, Locarno A, Forti L, Barbiero I, Tramarin M, Chandola C, Kilstrup-Nielsen C, Landsberger N
Journal of Biological Chemistry 2015;290(7):4512-4527
Journal of Biological Chemistry 2015;290(7):4512-4527
CDKL5 ensures excitatory synapse stability by reinforcing NGL-1–PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons
Ricciardi S, Ungaro F, Hambrock M, Rademacher N, Stefanelli G, Brambilla D, Sessa A, Magagnotti C, Bachi A, Giarda E, Verpelli C, Kilstrup-Nielsen C, Sala C, Kalscheuer V, Broccoli V
Nature Cell Biology 2012;14(9):911-923
Nature Cell Biology 2012;14(9):911-923
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