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Learn11733-1-AP
antibody from Proteintech Group
Targeting: CUX1
CASP, CDP, CDP/Cut, CDP/Cux, CDP1, Clox, CUT, CUTL1, CUX, Cux/CDP, GOLIM6
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [113]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- 11733-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11733-1-AP, RRID:AB_2086995
- Product name
- CUX1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CUX1 antibody (Cat. #11733-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A new mouse mutant with a discrete mutation in Pcdhgc5 reveals that the Protocadherin γC5 isoform is not essential for dendrite arborization in the cerebral cortex.
Nonsense-mediated mRNA decay orchestrates neuronal migration and cortical lamination while modulating Reelin and ciliary gene regulatory networks.
Protocol for mouse vascular dementia model and evaluation of progressive tissue damage in subcortical white matter and adjacent cortex.
Early Isoflurane Exposure Is Associated With Delayed Adolescent Neurobehavioral Deficits, Accompanied by Dysregulation of FOXG1 and EB3.
ZNF280A and ACRV1 enhance aerobic glycolysis and drive ovarian cancer progression via the PI3K/AKT signaling pathway.
Anxiety-Associated Behaviors Following Ablation of Miro1 from Cortical Excitatory Neurons.
The transcription factor CUX1 exerts opposing roles in human and mouse adipocyte differentiation.
LPLAT11/MBOAT7-driven phosphatidylinositol remodeling ensures radial glial cell integrity in developing neocortex.
Biallelic variants in CELSR1 cause brain malformations, neurodevelopmental disorders and epilepsy in humans.
NG2-Glia Heterogeneity Across Cortical Layers.
Junction-mediating and regulatory protein (JMY) is a promoting protein for radial migration of cortical neurons.
Functional characterization of CASP, a CUX1 isoform, reveals its tumor-promoting role in colorectal cancer via TRIM21-mediated signaling.
Reducing methylation of histone 3.3 lysine 4 in the medial ganglionic eminence and hypothalamus recapitulates neurodevelopmental disorder phenotypes.
The G-Protein-Coupled Receptor Kinase 2 Orchestrates Hair Follicle Homeostasis.
Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs-cAMP Signaling.
In rats, neurodevelopmental disorders induced by maternal hypoxia are associated with attenuated excitatory neurotransmission in the cingulate cortex.
Uncoupling neocortical neuron fate and migration via a Let-7-RBX2 axis.
DNA damage burden causes selective CUX2 neuron loss in neuroinflammation.
Porphyromonas gingivalis outer membrane vesicles alter cortical neurons and Tau phosphorylation in the embryonic mouse brain.
Uncoupling Neocortical Neuron Fate and Migration via a Let-7-RBX2 Axis.
Cadherin-6 controls neuronal migration during mouse neocortical development via an integrin-mediated pathway.
Imp1 acts as a dosage- and stage-dependent temporal rheostat orchestrating radial glial fate transitions and cortical morphogenesis.
IFITM2 Modulates Endocytosis Maintaining Neural Stem Cells in Developing Neocortex.
Proteomic profiling of primary cilia in the developing brain uncovers new regulators of cortical development.
miR-29a-3p compositely regulates the COL6A6/PTEN-PI3K/Akt/CUX1 feedback loop to participate in the proliferation and invasion of pituitary adenomas.
Duplication of the autism-related gene Chd8 leads to behavioral hyperactivity and neurodevelopmental defects in mice.
Mef2c Controls Postnatal Callosal Axon Targeting by Regulating Sensitivity to Ephrin Repulsion.
Perturbed cell fate decision by schizophrenia-associated AS3MT(d2d3) isoform during corticogenesis.
Cell-type-specific roles of FOXP1 in the excitatory neuronal lineage during early neocortical murine development.
Foxg1 gene mutation impairs auditory cortex response and reduces sound tolerance.
Novel mouse model reveals neurodevelopmental origin of PMM2-CDG brain pathology.
Extended NGN2 Expression in iPSCs Dramatically Enhances Purity of Neuronal Cultures.
Impact of ATF6 deletion on the embryonic brain development.
Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2.
Cyclin-dependent kinase inhibitor p18 regulates lineage transitions of excitatory neurons, astrocytes, and interneurons in the mouse cortex.
Mef2c Controls Postnatal Callosal Axon Targeting by Regulating Sensitivity to Ephrin Repulsion.
NUBP2 deficiency disrupts the centrosome-check point in the brain and causes primary microcephaly.
Schizophrenia-related Xpo7 haploinsufficiency leads to behavioral and nuclear transport pathologies.
Differential neurogenic patterns underlie the formation of primary and secondary areas in the developing somatosensory cortex.
Cortex-Specific Tmem169 Deficiency Induces Defects in Cortical Neuron Development and Autism-Like Behaviors in Mice.
Cell type-specific roles of FOXP1 in the excitatory neuronal lineage during early neocortical murine development.
Axon initial segment damage and hyperexcitability in a mutant mouse with increased calpain-dependent cleavage of αII-Spectrin.
Syngap1 and the development of murine neocortical progenitor cells.
Human CLOCK enhances neocortical function.
Aberrant generation of dentate gyrus granule cells is associated with epileptic susceptibility in p53 conditional knockout mice.
Fully defined NGN2 neuron protocol reveals diverse signatures of neuronal maturation.
Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion.
Cortico-thalamic communication for action coordination in a skilled motor sequence.
Loss of TET Activity in the Postnatal Mouse Brain Perturbs Synaptic Gene Expression and Impairs Cognitive Function.
Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition.
BRN1/2 Function in Neocortical Size Determination and Microcephaly.
A C-terminal motif containing a PKC phosphorylation site regulates γ-Protocadherin-mediated dendrite arborization in the cerebral cortex in vivo.
iPSC-derived models of PACS1 syndrome reveal transcriptional and functional deficits in neuron activity.
A C-terminal motif containing a PKC phosphorylation site regulates γ-Protocadherin-mediated dendrite arborization in the cerebral cortex in vivo.
Disruption of lysosomal nutrient sensing scaffold contributes to pathogenesis of a fatal neurodegenerative lysosomal storage disease.
Neonatal brain injury unravels transcriptional and signaling changes underlying the reactivation of cortical progenitors.
The GDNF-gel/HA-Mg conduit promotes the repair of peripheral nerve defects by regulating PPAR-γ/RhoA/ROCK signaling pathway.
Syngap1 and the development of murine neocortical progenitor cells.
DCX knockout ferret reveals a neurogenic mechanism in cortical development.
Loss of Zmiz1 in mice leads to impaired cortical development and autistic-like behaviors.
Dissecting reactive astrocyte responses: lineage tracing and morphology-based clustering.
Antisense oligonucleotides restore excitability, GABA signalling and sodium current density in a Dravet syndrome model.
P53 independent pathogenic mechanisms contribute to BubR1 microcephaly.
Taok1 haploinsufficiency leads to autistic-like behaviors in mice via the dorsal raphe nucleus.
CUX1-related neurodevelopmental disorder: deep insights into phenotype-genotype spectrum and underlying pathology.
Pituitary adenylate cyclase-activating polypeptide deficient mice show length abnormalities of the axon initial segment.
Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development.
Neuroanatomical Alterations in the CNTNAP2 Mouse Model of Autism Spectrum Disorder.
Notch directs telencephalic development and controls neocortical neuron fate determination by regulating microRNA levels.
A Robust Pipeline for the Multi-Stage Accelerated Differentiation of Functional 3D Cortical Organoids from Human Pluripotent Stem Cells.
An entosis-like process induces mitotic disruption in Pals1 microcephaly pathogenesis.
Effect of CUX1 on the Proliferation of Hu Sheep Dermal Papilla Cells and on the Wnt/β-Catenin Signaling Pathway.
RNA methylation-related genes of m6A, m5C, and m1A predict prognosis and immunotherapy response in cervical cancer.
An adhesion signaling axis involving Dystroglycan, β1-Integrin, and Cas adaptor proteins regulates the establishment of the cortical glial scaffold.
XLF/Cernunnos loss impairs mouse brain development by altering symmetric proliferative divisions of neural progenitors.
Npas3 regulates stemness maintenance of radial glial cells and neuronal migration in the developing mouse cerebral cortex.
Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions.
Increased glycine contributes to synaptic dysfunction and early mortality in Nprl2 seizure model.
TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss.
Divergent transcriptional regulation of astrocyte reactivity across disorders.
CUX1 promotes epithelial-mesenchymal transition (EMT) in renal fibrosis of UUO model by targeting MMP7.
Post-GWAS functional analysis identifies CUX1 as a regulator of p16(INK4a) and cellular senescence.
Length impairments of the axon initial segment in rodent models of attention-deficit hyperactivity disorder and autism spectrum disorder.
Merkel cell polyomavirus small T antigen is a viral transcription activator that is essential for viral genome maintenance.
GRN-/- iPSC-derived cortical neurons recapitulate the pathological findings of both frontotemporal lobar degeneration and neuronal ceroidolipofuscinosis.
Single-Cell Transcriptomics Reveals the Molecular Anatomy of Sheep Hair Follicle Heterogeneity and Wool Curvature.
Restoration of Visual Function and Cortical Connectivity After Ischemic Injury Through NeuroD1-Mediated Gene Therapy.
CUX1 Facilitates the Development of Oncogenic Properties Via Activating Wnt/β-Catenin Signaling Pathway in Glioma.
Neuroserpin Is Strongly Expressed in the Developing and Adult Mouse Neocortex but Its Absence Does Not Perturb Cortical Lamination and Synaptic Proteome.
RHEB/mTOR hyperactivity causes cortical malformations and epileptic seizures through increased axonal connectivity.
IgSF11 homophilic adhesion proteins promote layer-specific synaptic assembly of the cortical interneuron subtype.
Cellular and Behavioral Characterization of Pcdh19 Mutant Mice: subtle Molecular Changes, Increased Exploratory Behavior and an Impact of Social Environment.
Centrosome defects cause microcephaly by activating the 53BP1-USP28-TP53 mitotic surveillance pathway.
Overexpressed P75CUX1 promotes EMT in glioma infiltration by activating β-catenin.
Astragalus polysaccharide regulates brown adipogenic differentiation through miR-1258-5p-modulated cut-like homeobox 1 expression.
miR-143 Targeting CUX1 to Regulate Proliferation of Dermal Papilla Cells in Hu Sheep.
Differential Expression Levels of Sox9 in Early Neocortical Radial Glial Cells Regulate the Decision between Stem Cell Maintenance and Differentiation.
ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.
Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia.
AIF3 splicing switch triggers neurodegeneration.
Liquid Biopsy of Extracellular Vesicle-Derived miR-193a-5p in Colorectal Cancer and Discovery of Its Tumor-Suppressor Functions.
GDE2-Dependent Activation of Canonical Wnt Signaling in Neurons Regulates Oligodendrocyte Maturation.
hGFAP-Positive Stem Cells Depend on Brg1 for Proper Formation of Cerebral and Cerebellar Structures.
Reversing a model of Parkinson's disease with in situ converted nigral neurons.
The basic helix-loop-helix transcription factor TCF4 impacts brain architecture as well as neuronal morphology and differentiation.
PRISM: A Progenitor-Restricted Intersectional Fate Mapping Approach Redefines Forebrain Lineages.
Large-Area Fluorescence and Electron Microscopic Correlative Imaging With Multibeam Scanning Electron Microscopy.
TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.
A trap mutant reveals the physiological client spectrum of TRC40.
Upregulated Expression of CUX1 Correlates with Poor Prognosis in Glioma Patients: a Bioinformatic Analysis.
Loss of homeoprotein Msx1 and Msx2 leading to athletic and kinematic impairment related to the increasing neural excitability of neurons in aberrant neocortex in mice.
Inactivating CUX1 mutations promote tumorigenesis.
Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.
Hanes CM, Steffen DM, Murray GC, Burgess RW, Weiner JA, Garrett AM
PloS one 2026;21(3):e0344863
PloS one 2026;21(3):e0344863
Nonsense-mediated mRNA decay orchestrates neuronal migration and cortical lamination while modulating Reelin and ciliary gene regulatory networks.
Lin L, Kubota N, Lam YL, Song MM, Zhang M, Zheng S
Cell reports 2026 Mar 24;45(3):117027
Cell reports 2026 Mar 24;45(3):117027
Protocol for mouse vascular dementia model and evaluation of progressive tissue damage in subcortical white matter and adjacent cortex.
Tian M, Llorente IL, Carmichael ST
STAR protocols 2026 Mar 20;7(1):104396
STAR protocols 2026 Mar 20;7(1):104396
Early Isoflurane Exposure Is Associated With Delayed Adolescent Neurobehavioral Deficits, Accompanied by Dysregulation of FOXG1 and EB3.
Chen K, Xia M, Li C, Ren Z, Li X
Developmental neurobiology 2026 Jul;86(3):e70033
Developmental neurobiology 2026 Jul;86(3):e70033
ZNF280A and ACRV1 enhance aerobic glycolysis and drive ovarian cancer progression via the PI3K/AKT signaling pathway.
Zhu D, Chen P, Yu L, Gao S, Liu Y, Pan S, Li L
The Journal of biological chemistry 2026 Jan;302(1):110993
The Journal of biological chemistry 2026 Jan;302(1):110993
Anxiety-Associated Behaviors Following Ablation of Miro1 from Cortical Excitatory Neurons.
Myers AK, Sakheim M, Rivell C, Fengler C, Festa LK, Guerra KM, Jarrahy L, Shin R, Case M, Chapman C, Basel L, Springer S, Kern N, Gidicsin J, Cho G, Kim S, Tighiouart M, Golden JA
eNeuro 2026 Jan;13(1)
eNeuro 2026 Jan;13(1)
The transcription factor CUX1 exerts opposing roles in human and mouse adipocyte differentiation.
Chen Y, Liu L, Calhoun RP, Cheng L, Steger D, Seale P
Molecular metabolism 2026 Jan;103:102290
Molecular metabolism 2026 Jan;103:102290
LPLAT11/MBOAT7-driven phosphatidylinositol remodeling ensures radial glial cell integrity in developing neocortex.
Ishino Y, Kishi Y, Iwama T, Kuwayama N, Arai H, Gotoh Y, Aoki J, Kono N
iScience 2026 Jan 16;29(1):114248
iScience 2026 Jan 16;29(1):114248
Biallelic variants in CELSR1 cause brain malformations, neurodevelopmental disorders and epilepsy in humans.
Bonardi CM, Møller RS, Ruiz-Reig N, Chai G, Madsen CG, Bayat A, Hammer TB, Fenger CD, Gardella E, Gawlinski P, Dawidziuk M, Wiszniewski W, Bekiesinska-Figatowska M, Cabet S, Rossi M, Lesca G, Gouy E, Jepsen B, Mieszczanek TS, Sanchez Russo R, Barr EE, Õunap K, Ilves P, Wojcik MH, Aittaleb M, Brusgaard K, Tissir F, Rubboli G
Nature communications 2026 Jan 13;17(1):862
Nature communications 2026 Jan 13;17(1):862
NG2-Glia Heterogeneity Across Cortical Layers.
Barriola S, Delgado-García LM, Ojalvo-Sanz AC, Pernia-Solanilla C, Figueres-Oñate M, López-Mascaraque L
Glia 2026 Feb;74(2):e70108
Glia 2026 Feb;74(2):e70108
Junction-mediating and regulatory protein (JMY) is a promoting protein for radial migration of cortical neurons.
Chen XR, Chen ZY, Qi SY, Huang QY, Wei LH, Chen MY, Li H, Huang N, Kang YX, Guo ZX, Jing XC, Tan GH, Liu YY
Cell death discovery 2026 Feb 26;12(1)
Cell death discovery 2026 Feb 26;12(1)
Functional characterization of CASP, a CUX1 isoform, reveals its tumor-promoting role in colorectal cancer via TRIM21-mediated signaling.
Zhou B, Hu W, Dai W, Xu K, Liu L, Zheng S, Wei Q, Chen T
iScience 2026 Feb 20;29(2):114783
iScience 2026 Feb 20;29(2):114783
Reducing methylation of histone 3.3 lysine 4 in the medial ganglionic eminence and hypothalamus recapitulates neurodevelopmental disorder phenotypes.
Li J, Tanzillo AF, Pizzirusso G, Caccavano A, Chittajallu R, Sohn M, Abebe D, Zhang Y, Pelkey KA, Dale RK, McBain CJ, Petros TJ
Nature communications 2026 Feb 20;17(1)
Nature communications 2026 Feb 20;17(1)
The G-Protein-Coupled Receptor Kinase 2 Orchestrates Hair Follicle Homeostasis.
Asensio A, Sanz-Flores M, Liakath-Ali K, Romo-Gallo A, Palacios-García J, Paramio JM, García-Escudero R, Mayor F Jr, Ribas C
The Journal of investigative dermatology 2026 Apr;146(4):930-953.e9
The Journal of investigative dermatology 2026 Apr;146(4):930-953.e9
Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs-cAMP Signaling.
Liu WT, Hu ZB, Hu L, Wang YB, Zhang Q, Song NN, Liu XY, Chen JY, Zhu HW, Zhou BY, Tao YC, Zhao L, Li ZX, Li YW, Chen JQ, Tu SX, Qi CC, Ding SD, Peng G, Xu L, Ding YQ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(21):e19388
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(21):e19388
In rats, neurodevelopmental disorders induced by maternal hypoxia are associated with attenuated excitatory neurotransmission in the cingulate cortex.
Tokudome K, Ueki M, Homma T, Matsunaga S, Shimizu S, Ohno Y, Tomita S
British journal of pharmacology 2026 Apr 8;
British journal of pharmacology 2026 Apr 8;
Uncoupling neocortical neuron fate and migration via a Let-7-RBX2 axis.
Decker SC, Hino K, La Torre A, Simó S
Proceedings of the National Academy of Sciences of the United States of America 2026 Apr 28;123(17):e2528396123
Proceedings of the National Academy of Sciences of the United States of America 2026 Apr 28;123(17):e2528396123
DNA damage burden causes selective CUX2 neuron loss in neuroinflammation.
Morcom L, Xia W, Xu Z, Awasthi Y, Geywitz C, Ellis MO, Noli T, Zulji A, Yamamoto D, Girdler GC, Kai L, Zhu K, Wei M, Tang XY, Hoi KK, Gonzalez-Maya J, Duncan GJ, Vaquie AM, Gold Diaz D, Kawaguchi R, Liu E, Sun Y, Yang D, Jordan GD, Lu IL, Holmqvist S, Bartels T, Ridley K, Choi JJ, Franco SJ, Huang EJ, Emery B, Geschwind D, Schirmer L, Balmus G, Popko B, Fancy SPJ, Rowitch DH
Nature 2026 Apr 1;
Nature 2026 Apr 1;
Porphyromonas gingivalis outer membrane vesicles alter cortical neurons and Tau phosphorylation in the embryonic mouse brain.
J Bradley A, Mashburn-Warren L, Blalock LC, Scarpetti F, Lauber CL
PloS one 2025;20(3):e0310482
PloS one 2025;20(3):e0310482
Uncoupling Neocortical Neuron Fate and Migration via a Let-7-RBX2 Axis.
Decker S, Hino K, La Torre A, Simó S
bioRxiv : the preprint server for biology 2025 Sep 16;
bioRxiv : the preprint server for biology 2025 Sep 16;
Cadherin-6 controls neuronal migration during mouse neocortical development via an integrin-mediated pathway.
Hirota Y, Saito R, Honda T, Sano H, Hotta M, Inoue YU, Inoue T, Nakajima K
The FEBS journal 2025 Oct;292(20):5382-5397
The FEBS journal 2025 Oct;292(20):5382-5397
Imp1 acts as a dosage- and stage-dependent temporal rheostat orchestrating radial glial fate transitions and cortical morphogenesis.
Azur RAG, Feliciano D, Espinosa-Medina I, Adhikari R, Lilao-Garzón J, Jensen E, Yang CP, Lee T
bioRxiv : the preprint server for biology 2025 Nov 18;
bioRxiv : the preprint server for biology 2025 Nov 18;
IFITM2 Modulates Endocytosis Maintaining Neural Stem Cells in Developing Neocortex.
Lv Y, Zou W, Li L, Zhang S, Liang J, Pu J, Jiao J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2501593
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2501593
Proteomic profiling of primary cilia in the developing brain uncovers new regulators of cortical development.
Liu X, Gutierrez OT, Kaur G, Al-Issa Y, Baboo S, Diedrich JK, Cai E, Yates JR 3rd, Ge X
bioRxiv : the preprint server for biology 2025 May 4;
bioRxiv : the preprint server for biology 2025 May 4;
miR-29a-3p compositely regulates the COL6A6/PTEN-PI3K/Akt/CUX1 feedback loop to participate in the proliferation and invasion of pituitary adenomas.
Liu Z, Liao X, Zhao H, Ruan B, Jia F, He X, Long R
Journal of molecular histology 2025 May 27;56(3):172
Journal of molecular histology 2025 May 27;56(3):172
Duplication of the autism-related gene Chd8 leads to behavioral hyperactivity and neurodevelopmental defects in mice.
Kawamura A, Fujii K, Tamada K, Abe Y, Nitahara K, Iwasaki T, Yagishita S, Tanaka KF, Takumi T, Takao K, Nishiyama M
Nature communications 2025 May 26;16(1):4641
Nature communications 2025 May 26;16(1):4641
Mef2c Controls Postnatal Callosal Axon Targeting by Regulating Sensitivity to Ephrin Repulsion.
Sudarsanam S, Guzman-Clavel LE, Dar N, Ziak J, Shahid N, Jin XO, Kolodkin AL
The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 May 21;45(21)
The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 May 21;45(21)
Perturbed cell fate decision by schizophrenia-associated AS3MT(d2d3) isoform during corticogenesis.
Kim S, Woo Y, Um D, Chun I, Noh SJ, Ji HA, Jung N, Goo BS, Yoo JY, Mun DJ, Nghi TD, Nhung TTM, Han SH, Lee SB, Lee W, Yun J, So KH, Kim DK, Jang H, Suh Y, Rah JC, Baek ST, Yoon KJ, Kim MS, Kim TK, Park SK
Science advances 2025 Mar 28;11(13):eadp8271
Science advances 2025 Mar 28;11(13):eadp8271
Cell-type-specific roles of FOXP1 in the excitatory neuronal lineage during early neocortical murine development.
Ortiz A, Ayhan F, Khandelwal N, Outland E, Jankovic M, Harper M, Konopka G
Cell reports 2025 Mar 25;44(3):115384
Cell reports 2025 Mar 25;44(3):115384
Foxg1 gene mutation impairs auditory cortex response and reduces sound tolerance.
Xu F, Chen G, Jeon S, Ling L, Manohar S, Ding D, Auerbach BD, Lee J, Lee SK, Sun W
Cerebral cortex (New York, N.Y. : 1991) 2025 Jun 4;35(6)
Cerebral cortex (New York, N.Y. : 1991) 2025 Jun 4;35(6)
Novel mouse model reveals neurodevelopmental origin of PMM2-CDG brain pathology.
Edmondson AC, Budhraja R, Xia Z, Melendez-Perez A, Cai C, Radenkovic S, Collins AM, Shiplett EJ, Hill SF, Somarowthu A, Dam J, Pai LL, Santi M, Kim S, He M, Goldberg EM, Kozicz T, Morava E, Pandey A, Zhou Z
bioRxiv : the preprint server for biology 2025 Jun 3;
bioRxiv : the preprint server for biology 2025 Jun 3;
Extended NGN2 Expression in iPSCs Dramatically Enhances Purity of Neuronal Cultures.
Muñoz-Estrada J, Mostafania A, Halwatura L, Haghani A, Jiang Y, Meyer JG
bioRxiv : the preprint server for biology 2025 Jun 21;
bioRxiv : the preprint server for biology 2025 Jun 21;
Impact of ATF6 deletion on the embryonic brain development.
Nguyen LD, Nguyen LH, Dao DX, Hattori T, Takarada-Iemata M, Ishii H, Tamatani T, Kawasaki H, Shinmyo Y, Onoue K, Yonemura S, Zhang J, Miyake M, Oyadomari S, Mori K, Hori O
iScience 2025 Jun 20;28(6):112569
iScience 2025 Jun 20;28(6):112569
Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2.
He Q, Wang Z, Wang Y, Zhu M, Liang Z, Zhang K, Xu Y, Chen G
Neural regeneration research 2025 Jun 1;20(6):1801-1815
Neural regeneration research 2025 Jun 1;20(6):1801-1815
Cyclin-dependent kinase inhibitor p18 regulates lineage transitions of excitatory neurons, astrocytes, and interneurons in the mouse cortex.
Lee W, Kang B, Kim HM, Ishida T, Shin M, Iwashita M, Nitta M, Shiraishi A, Kiyonari H, Shimoya K, Masamoto K, Roh TY, Kosodo Y
The EMBO journal 2025 Jan;44(2):382-412
The EMBO journal 2025 Jan;44(2):382-412
Mef2c Controls Postnatal Callosal Axon Targeting by Regulating Sensitivity to Ephrin Repulsion.
Sudarsanam S, Guzman-Clavel L, Dar N, Ziak J, Shahid N, Jin XO, Kolodkin AL
bioRxiv : the preprint server for biology 2025 Jan 22;
bioRxiv : the preprint server for biology 2025 Jan 22;
NUBP2 deficiency disrupts the centrosome-check point in the brain and causes primary microcephaly.
Rushforth R, Shamseldin HE, Costantino N, Michaels JR, Sawyer SL, Osmond M, Kurdi W, Abdulwahab F, DiStasio A, Care4Rare Canada Consortium, Boycott KM, Alkuraya FS, Stottmann RW
medRxiv : the preprint server for health sciences 2025 Jan 17;
medRxiv : the preprint server for health sciences 2025 Jan 17;
Schizophrenia-related Xpo7 haploinsufficiency leads to behavioral and nuclear transport pathologies.
Toyoda S, Kikuchi M, Abe Y, Tashiro K, Handa T, Katayama S, Motokawa Y, Tanaka KF, Takahashi H, Shiwaku H
EMBO reports 2025 Feb;26(4):948-981
EMBO reports 2025 Feb;26(4):948-981
Differential neurogenic patterns underlie the formation of primary and secondary areas in the developing somatosensory cortex.
Ohte N, Kimura T, Sekine R, Yoshizawa S, Furusho Y, Sato D, Nishiyama C, Hanashima C
Cerebral cortex (New York, N.Y. : 1991) 2025 Feb 5;35(2)
Cerebral cortex (New York, N.Y. : 1991) 2025 Feb 5;35(2)
Cortex-Specific Tmem169 Deficiency Induces Defects in Cortical Neuron Development and Autism-Like Behaviors in Mice.
Wang J, Zhang J, Li J, Gao Q, Chen J, Jia C, Gu X
The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 Feb 26;45(9)
The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 Feb 26;45(9)
Cell type-specific roles of FOXP1 in the excitatory neuronal lineage during early neocortical murine development.
Ortiz A, Ayhan F, Khandelwal N, Outland E, Jankovic M, Harper M, Konopka G
bioRxiv : the preprint server for biology 2025 Feb 20;
bioRxiv : the preprint server for biology 2025 Feb 20;
Axon initial segment damage and hyperexcitability in a mutant mouse with increased calpain-dependent cleavage of αII-Spectrin.
Hobbib RL, Vakilzadeh G, Barriendos DF, Del Angel YC, González MI
Neurobiology of disease 2025 Dec;217:107156
Neurobiology of disease 2025 Dec;217:107156
Syngap1 and the development of murine neocortical progenitor cells.
Barão S, Xu Y, Hong I, Müller U, Huganir RL
Nature communications 2025 Dec 11;16(1):11060
Nature communications 2025 Dec 11;16(1):11060
Human CLOCK enhances neocortical function.
Liu Y, Fontenot MR, Kulkarni A, Khandelwal N, Voth Park SHE, Criswell C, Harper M, Xu P, Gupta N, Gibson JR, Takahashi JS, Konopka G
Nature neuroscience 2025 Aug;28(8):1716-1728
Nature neuroscience 2025 Aug;28(8):1716-1728
Aberrant generation of dentate gyrus granule cells is associated with epileptic susceptibility in p53 conditional knockout mice.
Ruiz-Reig N, Chehade G, Yerna X, Durá I, Gailly P, Tissir F
Frontiers in neuroscience 2024;18:1418973
Frontiers in neuroscience 2024;18:1418973
Fully defined NGN2 neuron protocol reveals diverse signatures of neuronal maturation.
Shan X, Zhang A, Rezzonico MG, Tsai MC, Sanchez-Priego C, Zhang Y, Chen MB, Choi M, Andrade López JM, Phu L, Cramer AL, Zhang Q, Pattison JM, Rose CM, Hoogenraad CC, Jeong CG
Cell reports methods 2024 Sep 16;4(9):100858
Cell reports methods 2024 Sep 16;4(9):100858
Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion.
Barão S, Xu Y, Llongueras JP, Vistein R, Goff L, Nielsen KJ, Bae BI, Smith RS, Walsh CA, Stein-O'Brien G, Müller U
Nature communications 2024 Sep 14;15(1):8043
Nature communications 2024 Sep 14;15(1):8043
Cortico-thalamic communication for action coordination in a skilled motor sequence.
Li Y, An X, Mulcahey PJ, Qian Y, Xu XH, Zhao S, Mohan H, Suryanarayana SM, Bachschmid-Romano L, Brunel N, Whishaw IQ, Huang ZJ
bioRxiv : the preprint server for biology 2024 Oct 30;
bioRxiv : the preprint server for biology 2024 Oct 30;
Loss of TET Activity in the Postnatal Mouse Brain Perturbs Synaptic Gene Expression and Impairs Cognitive Function.
Liu JW, Zhang ZQ, Zhu ZC, Li K, Xu Q, Zhang J, Cheng XW, Li H, Sun Y, Wang JJ, Hu LL, Xiong ZQ, Zhu Y
Neuroscience bulletin 2024 Nov;40(11):1699-1712
Neuroscience bulletin 2024 Nov;40(11):1699-1712
Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition.
Libé-Philippot B, Iwata R, Recupero AJ, Wierda K, Bernal Garcia S, Hammond L, van Benthem A, Limame R, Ditkowska M, Beckers S, Gaspariunaite V, Peze-Heidsieck E, Remans D, Charrier C, Theys T, Polleux F, Vanderhaeghen P
Neuron 2024 Nov 6;112(21):3602-3617.e9
Neuron 2024 Nov 6;112(21):3602-3617.e9
BRN1/2 Function in Neocortical Size Determination and Microcephaly.
Barão S, Xu Y, Llongueras JP, Vistein R, Goff L, Nielsen K, Bae BI, Smith RS, Walsh CA, Stein-O'Brien G, Müller U
bioRxiv : the preprint server for biology 2024 May 15;
bioRxiv : the preprint server for biology 2024 May 15;
A C-terminal motif containing a PKC phosphorylation site regulates γ-Protocadherin-mediated dendrite arborization in the cerebral cortex in vivo.
Hanes CM, Mah KM, Steffen DM, McLeod CM, Marcucci CG, Fuller LC, Burgess RW, Garrett AM, Weiner JA
Developmental neurobiology 2024 Jul;84(3):217-235
Developmental neurobiology 2024 Jul;84(3):217-235
iPSC-derived models of PACS1 syndrome reveal transcriptional and functional deficits in neuron activity.
Rylaarsdam L, Rakotomamonjy J, Pope E, Guemez-Gamboa A
Nature communications 2024 Jan 27;15(1):827
Nature communications 2024 Jan 27;15(1):827
A C-terminal motif containing a PKC phosphorylation site regulates γ-Protocadherin-mediated dendrite arborization in the cerebral cortex in vivo.
Hanes CM, Mah KM, Steffen DM, Marcucci CG, Fuller LC, Burgess RW, Garrett AM, Weiner JA
bioRxiv : the preprint server for biology 2024 Jan 25;
bioRxiv : the preprint server for biology 2024 Jan 25;
Disruption of lysosomal nutrient sensing scaffold contributes to pathogenesis of a fatal neurodegenerative lysosomal storage disease.
Bagh MB, Appu AP, Sadhukhan T, Mondal A, Plavelil N, Raghavankutty M, Supran AM, Sadhukhan S, Liu A, Mukherjee AB
The Journal of biological chemistry 2024 Feb;300(2):105641
The Journal of biological chemistry 2024 Feb;300(2):105641
Neonatal brain injury unravels transcriptional and signaling changes underlying the reactivation of cortical progenitors.
Foucault L, Capeliez T, Angonin D, Lentini C, Bezin L, Heinrich C, Parras C, Donega V, Marcy G, Raineteau O
Cell reports 2024 Feb 27;43(2):113734
Cell reports 2024 Feb 27;43(2):113734
The GDNF-gel/HA-Mg conduit promotes the repair of peripheral nerve defects by regulating PPAR-γ/RhoA/ROCK signaling pathway.
Cai Y, Chen Y, Zhang G, Lin Y, Zhang J, Liang J, Lv L, Wang Y, Fang X, Dang X
iScience 2024 Feb 16;27(2):108969
iScience 2024 Feb 16;27(2):108969
Syngap1 and the development of murine neocortical progenitor cells.
Barão S, Hong I, Müller U, Huganir RL
bioRxiv : the preprint server for biology 2024 Dec 20;
bioRxiv : the preprint server for biology 2024 Dec 20;
DCX knockout ferret reveals a neurogenic mechanism in cortical development.
Wang W, Yin C, Wen S, Liu Z, Wang B, Zeng B, Sun L, Zhou X, Zhong S, Zhang J, Ma W, Wu Q, Wang X
Cell reports 2024 Aug 27;43(8):114508
Cell reports 2024 Aug 27;43(8):114508
Loss of Zmiz1 in mice leads to impaired cortical development and autistic-like behaviors.
K C R, Patel NR, Thurmon AN, Lorino MG, Tiemroth AS, Kulstad I, Morrison V, Akumuo M, Shenoy A, Meadows SM, Galazo MJ
bioRxiv : the preprint server for biology 2024 Aug 18;
bioRxiv : the preprint server for biology 2024 Aug 18;
Dissecting reactive astrocyte responses: lineage tracing and morphology-based clustering.
Delgado-García LM, Ojalvo-Sanz AC, Nakamura TKE, Martín-López E, Porcionatto M, Lopez-Mascaraque L
Biological research 2024 Aug 14;57(1):54
Biological research 2024 Aug 14;57(1):54
Antisense oligonucleotides restore excitability, GABA signalling and sodium current density in a Dravet syndrome model.
Yuan Y, Lopez-Santiago L, Denomme N, Chen C, O'Malley HA, Hodges SL, Ji S, Han Z, Christiansen A, Isom LL
Brain : a journal of neurology 2024 Apr 4;147(4):1231-1246
Brain : a journal of neurology 2024 Apr 4;147(4):1231-1246
P53 independent pathogenic mechanisms contribute to BubR1 microcephaly.
Sterling NA, Terry BK, McDonnell JM, Kim S
Frontiers in cell and developmental biology 2023;11:1282182
Frontiers in cell and developmental biology 2023;11:1282182
Taok1 haploinsufficiency leads to autistic-like behaviors in mice via the dorsal raphe nucleus.
Wang J, Li W, Li Z, Xue Z, Zhang Y, Yuan Y, Shi Y, Shan S, Han W, Li F, Qiu Z
Cell reports 2023 Sep 26;42(9):113078
Cell reports 2023 Sep 26;42(9):113078
CUX1-related neurodevelopmental disorder: deep insights into phenotype-genotype spectrum and underlying pathology.
Oppermann H, Marcos-Grañeda E, Weiss LA, Gurnett CA, Jelsig AM, Vineke SH, Isidor B, Mercier S, Magnussen K, Zacher P, Hashim M, Pagnamenta AT, Race S, Srivastava S, Frazier Z, Maiwald R, Pergande M, Milani D, Rinelli M, Levy J, Krey I, Fontana P, Lonardo F, Riley S, Kretzer J, Rankin J, Reis LM, Semina EV, Reuter MS, Scherer SW, Iascone M, Weis D, Fagerberg CR, Brasch-Andersen C, Hansen LK, Kuechler A, Noble N, Gardham A, Tenney J, Rathore G, Beck-Woedl S, Haack TB, Pavlidou DC, Atallah I, Vodopiutz J, Janecke AR, Hsieh TC, Lesmann H, Klinkhammer H, Krawitz PM, Lemke JR, Jamra RA, Nieto M, Tümer Z, Platzer K
European journal of human genetics : EJHG 2023 Nov;31(11):1251-1260
European journal of human genetics : EJHG 2023 Nov;31(11):1251-1260
Pituitary adenylate cyclase-activating polypeptide deficient mice show length abnormalities of the axon initial segment.
Iwahashi M, Yoshimura T, Harigai W, Takuma K, Hashimoto H, Katayama T, Hayata-Takano A
Journal of pharmacological sciences 2023 Nov;153(3):175-182
Journal of pharmacological sciences 2023 Nov;153(3):175-182
Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development.
Sun XL, Chen ZH, Guo X, Wang J, Ge M, Wong SZH, Wang T, Li S, Yao M, Johnston LA, Wu QF
Developmental cell 2023 May 8;58(9):744-759.e11
Developmental cell 2023 May 8;58(9):744-759.e11
Neuroanatomical Alterations in the CNTNAP2 Mouse Model of Autism Spectrum Disorder.
Gandhi T, Canepa CR, Adeyelu TT, Adeniyi PA, Lee CC
Brain sciences 2023 May 31;13(6)
Brain sciences 2023 May 31;13(6)
Notch directs telencephalic development and controls neocortical neuron fate determination by regulating microRNA levels.
Han JS, Fishman-Williams E, Decker SC, Hino K, Reyes RV, Brown NL, Simó S, Torre A
Development (Cambridge, England) 2023 Jun 1;150(11)
Development (Cambridge, England) 2023 Jun 1;150(11)
A Robust Pipeline for the Multi-Stage Accelerated Differentiation of Functional 3D Cortical Organoids from Human Pluripotent Stem Cells.
Whye D, Wood D, Saber WA, Norabuena EM, Makhortova NR, Sahin M, Buttermore ED
Current protocols 2023 Jan;3(1):e641
Current protocols 2023 Jan;3(1):e641
An entosis-like process induces mitotic disruption in Pals1 microcephaly pathogenesis.
Sterling NA, Park JY, Park R, Cho SH, Kim S
Nature communications 2023 Jan 5;14(1):82
Nature communications 2023 Jan 5;14(1):82
Effect of CUX1 on the Proliferation of Hu Sheep Dermal Papilla Cells and on the Wnt/β-Catenin Signaling Pathway.
Zhou H, Huang S, Lv X, Wang S, Cao X, Yuan Z, Getachew T, Mwacharo JM, Haile A, Quan K, Li Y, Reverter A, Sun W
Genes 2023 Feb 7;14(2)
Genes 2023 Feb 7;14(2)
RNA methylation-related genes of m6A, m5C, and m1A predict prognosis and immunotherapy response in cervical cancer.
Wang Y, Mao Y, Wang C, Jiang X, Tang Q, Wang L, Zhu J, Zhao M
Annals of medicine 2023 Dec;55(1):2190618
Annals of medicine 2023 Dec;55(1):2190618
An adhesion signaling axis involving Dystroglycan, β1-Integrin, and Cas adaptor proteins regulates the establishment of the cortical glial scaffold.
Wong W, Estep JA, Treptow AM, Rajabli N, Jahncke JN, Ubina T, Wright KM, Riccomagno MM
PLoS biology 2023 Aug;21(8):e3002212
PLoS biology 2023 Aug;21(8):e3002212
XLF/Cernunnos loss impairs mouse brain development by altering symmetric proliferative divisions of neural progenitors.
Bery A, Etienne O, Mouton L, Mokrani S, Granotier-Beckers C, Gauthier LR, Feat-Vetel J, Kortulewski T, Pérès EA, Desmaze C, Lestaveal P, Barroca V, Laugeray A, Boumezbeur F, Abramovski V, Mortaud S, Menuet A, Le Bihan D, Villartay JP, Boussin FD
Cell reports 2023 Apr 25;42(4):112342
Cell reports 2023 Apr 25;42(4):112342
Npas3 regulates stemness maintenance of radial glial cells and neuronal migration in the developing mouse cerebral cortex.
Liu JW, Li H, Zhang Y
Frontiers in cellular neuroscience 2022;16:865681
Frontiers in cellular neuroscience 2022;16:865681
Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions.
Chi S, Cui Y, Wang H, Jiang J, Zhang T, Sun S, Zhou Z, Zhong Y, Xiao B
Neuron 2022 Sep 21;110(18):2984-2999.e8
Neuron 2022 Sep 21;110(18):2984-2999.e8
Increased glycine contributes to synaptic dysfunction and early mortality in Nprl2 seizure model.
Dentel B, Angeles-Perez L, Ren C, Jakkamsetti V, Holley AJ, Caballero D, Oh E, Gibson J, Pascual JM, Huber KM, Tu BP, Tsai PT
iScience 2022 May 20;25(5):104334
iScience 2022 May 20;25(5):104334
TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss.
Feng T, Luan L, Katz II, Ullah M, Van Deerlin VM, Trojanowski JQ, Lee EB, Hu F
Acta neuropathologica communications 2022 Mar 14;10(1):33
Acta neuropathologica communications 2022 Mar 14;10(1):33
Divergent transcriptional regulation of astrocyte reactivity across disorders.
Burda JE, O'Shea TM, Ao Y, Suresh KB, Wang S, Bernstein AM, Chandra A, Deverasetty S, Kawaguchi R, Kim JH, McCallum S, Rogers A, Wahane S, Sofroniew MV
Nature 2022 Jun;606(7914):557-564
Nature 2022 Jun;606(7914):557-564
CUX1 promotes epithelial-mesenchymal transition (EMT) in renal fibrosis of UUO model by targeting MMP7.
Teng S, Liu G, Li L, Ou J, Yu Y
Biochemical and biophysical research communications 2022 Jun 11;608:128-134
Biochemical and biophysical research communications 2022 Jun 11;608:128-134
Post-GWAS functional analysis identifies CUX1 as a regulator of p16(INK4a) and cellular senescence.
Jiang D, Sun W, Wu T, Zou M, Vasamsetti SB, Zhang X, Zhao Y, Phillippi JA, Sawalha AH, Tavakoli S, Dutta P, Florentin J, Chan SY, Tollison TS, Di Wu, Cui J, Huntress I, Peng X, Finkel T, Li G
Nature aging 2022 Feb;2(2):140-154
Nature aging 2022 Feb;2(2):140-154
Length impairments of the axon initial segment in rodent models of attention-deficit hyperactivity disorder and autism spectrum disorder.
Usui N, Tian X, Harigai W, Togawa S, Utsunomiya R, Doi T, Miyoshi K, Shinoda K, Tanaka J, Shimada S, Katayama T, Yoshimura T
Neurochemistry international 2022 Feb;153:105273
Neurochemistry international 2022 Feb;153:105273
Merkel cell polyomavirus small T antigen is a viral transcription activator that is essential for viral genome maintenance.
Rapchak K, Yagobian SD, Moore J, Khattri M, Shuda M
PLoS pathogens 2022 Dec;18(12):e1011039
PLoS pathogens 2022 Dec;18(12):e1011039
GRN-/- iPSC-derived cortical neurons recapitulate the pathological findings of both frontotemporal lobar degeneration and neuronal ceroidolipofuscinosis.
Bossolasco P, Cimini S, Maderna E, Bardelli D, Canafoglia L, Cavallaro T, Ricci M, Silani V, Marucci G, Rossi G
Neurobiology of disease 2022 Dec;175:105891
Neurobiology of disease 2022 Dec;175:105891
Single-Cell Transcriptomics Reveals the Molecular Anatomy of Sheep Hair Follicle Heterogeneity and Wool Curvature.
Wang S, Wu T, Sun J, Li Y, Yuan Z, Sun W
Frontiers in cell and developmental biology 2021;9:800157
Frontiers in cell and developmental biology 2021;9:800157
Restoration of Visual Function and Cortical Connectivity After Ischemic Injury Through NeuroD1-Mediated Gene Therapy.
Tang Y, Wu Q, Gao M, Ryu E, Pei Z, Kissinger ST, Chen Y, Rao AK, Xiang Z, Wang T, Li W, Chen G, Chubykin AA
Frontiers in cell and developmental biology 2021;9:720078
Frontiers in cell and developmental biology 2021;9:720078
CUX1 Facilitates the Development of Oncogenic Properties Via Activating Wnt/β-Catenin Signaling Pathway in Glioma.
Feng F, Zhao Z, Zhou Y, Cheng Y, Wu X, Heng X
Frontiers in molecular biosciences 2021;8:705008
Frontiers in molecular biosciences 2021;8:705008
Neuroserpin Is Strongly Expressed in the Developing and Adult Mouse Neocortex but Its Absence Does Not Perturb Cortical Lamination and Synaptic Proteome.
Kement D, Reumann R, Schostak K, Voß H, Douceau S, Dottermusch M, Schweizer M, Schlüter H, Vivien D, Glatzel M, Galliciotti G
Frontiers in neuroanatomy 2021;15:627896
Frontiers in neuroanatomy 2021;15:627896
RHEB/mTOR hyperactivity causes cortical malformations and epileptic seizures through increased axonal connectivity.
Proietti Onori M, Koene LMC, Schäfer CB, Nellist M, de Brito van Velze M, Gao Z, Elgersma Y, van Woerden GM
PLoS biology 2021 May;19(5):e3001279
PLoS biology 2021 May;19(5):e3001279
IgSF11 homophilic adhesion proteins promote layer-specific synaptic assembly of the cortical interneuron subtype.
Hayano Y, Ishino Y, Hyun JH, Orozco CG, Steinecke A, Potts E, Oisi Y, Thomas CI, Guerrero-Given D, Kim E, Kwon HB, Kamasawa N, Taniguchi H
Science advances 2021 Jul;7(29)
Science advances 2021 Jul;7(29)
Cellular and Behavioral Characterization of Pcdh19 Mutant Mice: subtle Molecular Changes, Increased Exploratory Behavior and an Impact of Social Environment.
Galindo-Riera N, Newbold SA, Sledziowska M, Llinares-Benadero C, Griffiths J, Mire E, Martinez-Garay I
eNeuro 2021 Jul-Aug;8(4)
eNeuro 2021 Jul-Aug;8(4)
Centrosome defects cause microcephaly by activating the 53BP1-USP28-TP53 mitotic surveillance pathway.
Phan TP, Maryniak AL, Boatwright CA, Lee J, Atkins A, Tijhuis A, Spierings DC, Bazzi H, Foijer F, Jordan PW, Stracker TH, Holland AJ
The EMBO journal 2021 Jan 4;40(1):e106118
The EMBO journal 2021 Jan 4;40(1):e106118
Overexpressed P75CUX1 promotes EMT in glioma infiltration by activating β-catenin.
Xu A, Wang X, Luo J, Zhou M, Yi R, Huang T, Lin J, Wu Z, Xie C, Ding S, Zeng Y, Song Y
Cell death & disease 2021 Feb 4;12(2):157
Cell death & disease 2021 Feb 4;12(2):157
Astragalus polysaccharide regulates brown adipogenic differentiation through miR-1258-5p-modulated cut-like homeobox 1 expression.
Cao Y, Deng B, Zhang S, Gao H, Song P, Zhang J, Zhao J
Acta biochimica et biophysica Sinica 2021 Dec 8;53(12):1713-1722
Acta biochimica et biophysica Sinica 2021 Dec 8;53(12):1713-1722
miR-143 Targeting CUX1 to Regulate Proliferation of Dermal Papilla Cells in Hu Sheep.
Hu T, Huang S, Lv X, Wang S, Getachew T, Mwacharo JM, Haile A, Sun W
Genes 2021 Dec 18;12(12)
Genes 2021 Dec 18;12(12)
Differential Expression Levels of Sox9 in Early Neocortical Radial Glial Cells Regulate the Decision between Stem Cell Maintenance and Differentiation.
Fabra-Beser J, Alves Medeiros de Araujo J, Marques-Coelho D, Goff LA, Costa MR, Müller U, Gil-Sanz C
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Aug 18;41(33):6969-6986
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Aug 18;41(33):6969-6986
ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.
Medeiros de Araújo JA, Barão S, Mateos-White I, Espinosa A, Costa MR, Gil-Sanz C, Müller U
Development (Cambridge, England) 2021 Aug 15;148(16)
Development (Cambridge, England) 2021 Aug 15;148(16)
Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia.
Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella JF, Thomas P, Sauvageau G, Adams DJ, Wong CC
Nature communications 2021 Apr 30;12(1):2482
Nature communications 2021 Apr 30;12(1):2482
AIF3 splicing switch triggers neurodegeneration.
Liu S, Zhou M, Ruan Z, Wang Y, Chang C, Sasaki M, Rajaram V, Lemoff A, Nambiar K, Wang JE, Hatanpaa KJ, Luo W, Dawson TM, Dawson VL, Wang Y
Molecular neurodegeneration 2021 Apr 14;16(1):25
Molecular neurodegeneration 2021 Apr 14;16(1):25
Liquid Biopsy of Extracellular Vesicle-Derived miR-193a-5p in Colorectal Cancer and Discovery of Its Tumor-Suppressor Functions.
Wei R, Chen L, Qin D, Guo Q, Zhu S, Li P, Min L, Zhang S
Frontiers in oncology 2020;10:1372
Frontiers in oncology 2020;10:1372
GDE2-Dependent Activation of Canonical Wnt Signaling in Neurons Regulates Oligodendrocyte Maturation.
Choi BR, Cave C, Na CH, Sockanathan S
Cell reports 2020 May 5;31(5):107540
Cell reports 2020 May 5;31(5):107540
hGFAP-Positive Stem Cells Depend on Brg1 for Proper Formation of Cerebral and Cerebellar Structures.
Holdhof D, Schoof M, Hellwig M, Holdhof NH, Niesen J, Schüller U
Cerebral cortex (New York, N.Y. : 1991) 2020 Mar 14;30(3):1382-1392
Cerebral cortex (New York, N.Y. : 1991) 2020 Mar 14;30(3):1382-1392
Reversing a model of Parkinson's disease with in situ converted nigral neurons.
Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD
Nature 2020 Jun;582(7813):550-556
Nature 2020 Jun;582(7813):550-556
The basic helix-loop-helix transcription factor TCF4 impacts brain architecture as well as neuronal morphology and differentiation.
Schoof M, Hellwig M, Harrison L, Holdhof D, Lauffer MC, Niesen J, Virdi S, Indenbirken D, Schüller U
The European journal of neuroscience 2020 Jun;51(11):2219-2235
The European journal of neuroscience 2020 Jun;51(11):2219-2235
PRISM: A Progenitor-Restricted Intersectional Fate Mapping Approach Redefines Forebrain Lineages.
Poulin JF, Luppi MP, Hofer C, Caronia G, Hsu PK, Chan CS, Awatramani R
Developmental cell 2020 Jun 22;53(6):740-753.e3
Developmental cell 2020 Jun 22;53(6):740-753.e3
Large-Area Fluorescence and Electron Microscopic Correlative Imaging With Multibeam Scanning Electron Microscopy.
Shibata S, Iseda T, Mitsuhashi T, Oka A, Shindo T, Moritoki N, Nagai T, Otsubo S, Inoue T, Sasaki E, Akazawa C, Takahashi T, Schalek R, Lichtman JW, Okano H
Frontiers in neural circuits 2019;13:29
Frontiers in neural circuits 2019;13:29
TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.
Ivanova EL, Gilet JG, Sulimenko V, Duchon A, Rudolf G, Runge K, Collins SC, Asselin L, Broix L, Drouot N, Tilly P, Nusbaum P, Vincent A, Magnant W, Skory V, Birling MC, Pavlovic G, Godin JD, Yalcin B, Hérault Y, Dráber P, Chelly J, Hinckelmann MV
Nature communications 2019 May 13;10(1):2129
Nature communications 2019 May 13;10(1):2129
A trap mutant reveals the physiological client spectrum of TRC40.
Coy-Vergara J, Rivera-Monroy J, Urlaub H, Lenz C, Schwappach B
Journal of cell science 2019 Jul 1;132(13)
Journal of cell science 2019 Jul 1;132(13)
Upregulated Expression of CUX1 Correlates with Poor Prognosis in Glioma Patients: a Bioinformatic Analysis.
Wu X, Feng F, Yang C, Zhang M, Cheng Y, Zhao Y, Wang Y, Che F, Zhang J, Heng X
Journal of molecular neuroscience : MN 2019 Dec;69(4):527-537
Journal of molecular neuroscience : MN 2019 Dec;69(4):527-537
Loss of homeoprotein Msx1 and Msx2 leading to athletic and kinematic impairment related to the increasing neural excitability of neurons in aberrant neocortex in mice.
Yu B, Jin Y, Shen Y, Yang Y, Wang G, Zhu H, Yu Y, Wang J
Biochemical and biophysical research communications 2019 Aug 13;516(1):229-235
Biochemical and biophysical research communications 2019 Aug 13;516(1):229-235
Inactivating CUX1 mutations promote tumorigenesis.
Wong CC, Martincorena I, Rust AG, Rashid M, Alifrangis C, Alexandrov LB, Tiffen JC, Kober C, Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium, Green AR, Massie CE, Nangalia J, Lempidaki S, Döhner H, Döhner K, Bray SJ, McDermott U, Papaemmanuil E, Campbell PJ, Adams DJ
Nature genetics 2014 Jan;46(1):33-8
Nature genetics 2014 Jan;46(1):33-8
Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.
Gokhale A, Larimore J, Werner E, So L, Moreno-De-Luca A, Lese-Martin C, Lupashin VV, Smith Y, Faundez V
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Mar 14;32(11):3697-711
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Mar 14;32(11):3697-711
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 11733-1-AP(CUX1 antibody) at dilution of 1:2000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using CUX1 antibody 11733-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
