11733-1-AP

antibody from Proteintech Group

Targeting: CUX1 CASP, CDP, CDP/Cut, CDP/Cux, CDP1, Clox, CUT, CUTL1, CUX, Cux/CDP, GOLIM6

Provider product page for 11733-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [58]
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Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 11733-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11733-1-AP, RRID:AB_2086995
Product name: CUX1 antibody
Antibody type: Polyclonal
Description: KD/KO validated CUX1 antibody (Cat. #11733-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CUX1 protein structure - 11733-1-AP shown in red.

Submitted references Cortico-thalamic communication for action coordination in a skilled motor sequence.

Li Y, An X, Mulcahey PJ, Qian Y, Xu XH, Zhao S, Mohan H, Suryanarayana SM, Bachschmid-Romano L, Brunel N, Whishaw IQ, Huang ZJ
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BRN1/2 Function in Neocortical Size Determination and Microcephaly.

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Cell type specific roles of FOXP1 during early neocortical murine development.

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iPSC-derived models of PACS1 syndrome reveal transcriptional and functional deficits in neuron activity.

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A C-terminal motif containing a PKC phosphorylation site regulates γ-Protocadherin-mediated dendrite arborization in the cerebral cortex in vivo.

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bioRxiv : the preprint server for biology 2024 Jan 25;

Disruption of lysosomal nutrient sensing scaffold contributes to pathogenesis of a fatal neurodegenerative lysosomal storage disease.

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Neonatal brain injury unravels transcriptional and signaling changes underlying the reactivation of cortical progenitors.

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P53 independent pathogenic mechanisms contribute to BubR1 microcephaly.

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Frontiers in cell and developmental biology 2023;11:1282182

Taok1 haploinsufficiency leads to autistic-like behaviors in mice via the dorsal raphe nucleus.

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Cell reports 2023 Sep 26;42(9):113078

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European journal of human genetics : EJHG 2023 Nov;31(11):1251-1260

Pituitary adenylate cyclase-activating polypeptide deficient mice show length abnormalities of the axon initial segment.

Iwahashi M, Yoshimura T, Harigai W, Takuma K, Hashimoto H, Katayama T, Hayata-Takano A
Journal of pharmacological sciences 2023 Nov;153(3):175-182

Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development.

Sun XL, Chen ZH, Guo X, Wang J, Ge M, Wong SZH, Wang T, Li S, Yao M, Johnston LA, Wu QF
Developmental cell 2023 May 8;58(9):744-759.e11

Neuroanatomical Alterations in the CNTNAP2 Mouse Model of Autism Spectrum Disorder.

Gandhi T, Canepa CR, Adeyelu TT, Adeniyi PA, Lee CC
Brain sciences 2023 May 31;13(6)

Notch directs telencephalic development and controls neocortical neuron fate determination by regulating microRNA levels.

Han JS, Fishman-Williams E, Decker SC, Hino K, Reyes RV, Brown NL, Simó S, Torre A
Development (Cambridge, England) 2023 Jun 1;150(11)

A Robust Pipeline for the Multi-Stage Accelerated Differentiation of Functional 3D Cortical Organoids from Human Pluripotent Stem Cells.

Whye D, Wood D, Saber WA, Norabuena EM, Makhortova NR, Sahin M, Buttermore ED
Current protocols 2023 Jan;3(1):e641

An entosis-like process induces mitotic disruption in Pals1 microcephaly pathogenesis.

Sterling NA, Park JY, Park R, Cho SH, Kim S
Nature communications 2023 Jan 5;14(1):82

Effect of CUX1 on the Proliferation of Hu Sheep Dermal Papilla Cells and on the Wnt/β-Catenin Signaling Pathway.

Zhou H, Huang S, Lv X, Wang S, Cao X, Yuan Z, Getachew T, Mwacharo JM, Haile A, Quan K, Li Y, Reverter A, Sun W
Genes 2023 Feb 7;14(2)

RNA methylation-related genes of m6A, m5C, and m1A predict prognosis and immunotherapy response in cervical cancer.

Wang Y, Mao Y, Wang C, Jiang X, Tang Q, Wang L, Zhu J, Zhao M
Annals of medicine 2023 Dec;55(1):2190618

An adhesion signaling axis involving Dystroglycan, β1-Integrin, and Cas adaptor proteins regulates the establishment of the cortical glial scaffold.

Wong W, Estep JA, Treptow AM, Rajabli N, Jahncke JN, Ubina T, Wright KM, Riccomagno MM
PLoS biology 2023 Aug;21(8):e3002212

Npas3 regulates stemness maintenance of radial glial cells and neuronal migration in the developing mouse cerebral cortex.

Liu JW, Li H, Zhang Y
Frontiers in cellular neuroscience 2022;16:865681

Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions.

Chi S, Cui Y, Wang H, Jiang J, Zhang T, Sun S, Zhou Z, Zhong Y, Xiao B
Neuron 2022 Sep 21;110(18):2984-2999.e8

Increased glycine contributes to synaptic dysfunction and early mortality in Nprl2 seizure model.

Dentel B, Angeles-Perez L, Ren C, Jakkamsetti V, Holley AJ, Caballero D, Oh E, Gibson J, Pascual JM, Huber KM, Tu BP, Tsai PT
iScience 2022 May 20;25(5):104334

TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss.

Feng T, Luan L, Katz II, Ullah M, Van Deerlin VM, Trojanowski JQ, Lee EB, Hu F
Acta neuropathologica communications 2022 Mar 14;10(1):33

Divergent transcriptional regulation of astrocyte reactivity across disorders.

Burda JE, O'Shea TM, Ao Y, Suresh KB, Wang S, Bernstein AM, Chandra A, Deverasetty S, Kawaguchi R, Kim JH, McCallum S, Rogers A, Wahane S, Sofroniew MV
Nature 2022 Jun;606(7914):557-564

CUX1 promotes epithelial-mesenchymal transition (EMT) in renal fibrosis of UUO model by targeting MMP7.

Teng S, Liu G, Li L, Ou J, Yu Y
Biochemical and biophysical research communications 2022 Jun 11;608:128-134

Post-GWAS functional analysis identifies CUX1 as a regulator of p16(INK4a) and cellular senescence.

Jiang D, Sun W, Wu T, Zou M, Vasamsetti SB, Zhang X, Zhao Y, Phillippi JA, Sawalha AH, Tavakoli S, Dutta P, Florentin J, Chan SY, Tollison TS, Di Wu, Cui J, Huntress I, Peng X, Finkel T, Li G
Nature aging 2022 Feb;2(2):140-154

Length impairments of the axon initial segment in rodent models of attention-deficit hyperactivity disorder and autism spectrum disorder.

Usui N, Tian X, Harigai W, Togawa S, Utsunomiya R, Doi T, Miyoshi K, Shinoda K, Tanaka J, Shimada S, Katayama T, Yoshimura T
Neurochemistry international 2022 Feb;153:105273

Merkel cell polyomavirus small T antigen is a viral transcription activator that is essential for viral genome maintenance.

Rapchak K, Yagobian SD, Moore J, Khattri M, Shuda M
PLoS pathogens 2022 Dec;18(12):e1011039

GRN-/- iPSC-derived cortical neurons recapitulate the pathological findings of both frontotemporal lobar degeneration and neuronal ceroidolipofuscinosis.

Bossolasco P, Cimini S, Maderna E, Bardelli D, Canafoglia L, Cavallaro T, Ricci M, Silani V, Marucci G, Rossi G
Neurobiology of disease 2022 Dec;175:105891

Single-Cell Transcriptomics Reveals the Molecular Anatomy of Sheep Hair Follicle Heterogeneity and Wool Curvature.

Wang S, Wu T, Sun J, Li Y, Yuan Z, Sun W
Frontiers in cell and developmental biology 2021;9:800157

Restoration of Visual Function and Cortical Connectivity After Ischemic Injury Through NeuroD1-Mediated Gene Therapy.

Tang Y, Wu Q, Gao M, Ryu E, Pei Z, Kissinger ST, Chen Y, Rao AK, Xiang Z, Wang T, Li W, Chen G, Chubykin AA
Frontiers in cell and developmental biology 2021;9:720078

CUX1 Facilitates the Development of Oncogenic Properties Via Activating Wnt/β-Catenin Signaling Pathway in Glioma.

Feng F, Zhao Z, Zhou Y, Cheng Y, Wu X, Heng X
Frontiers in molecular biosciences 2021;8:705008

Neuroserpin Is Strongly Expressed in the Developing and Adult Mouse Neocortex but Its Absence Does Not Perturb Cortical Lamination and Synaptic Proteome.

Kement D, Reumann R, Schostak K, Voß H, Douceau S, Dottermusch M, Schweizer M, Schlüter H, Vivien D, Glatzel M, Galliciotti G
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RHEB/mTOR hyperactivity causes cortical malformations and epileptic seizures through increased axonal connectivity.

Proietti Onori M, Koene LMC, Schäfer CB, Nellist M, de Brito van Velze M, Gao Z, Elgersma Y, van Woerden GM
PLoS biology 2021 May;19(5):e3001279

IgSF11 homophilic adhesion proteins promote layer-specific synaptic assembly of the cortical interneuron subtype.

Hayano Y, Ishino Y, Hyun JH, Orozco CG, Steinecke A, Potts E, Oisi Y, Thomas CI, Guerrero-Given D, Kim E, Kwon HB, Kamasawa N, Taniguchi H
Science advances 2021 Jul;7(29)

Cellular and Behavioral Characterization of Pcdh19 Mutant Mice: subtle Molecular Changes, Increased Exploratory Behavior and an Impact of Social Environment.

Galindo-Riera N, Newbold SA, Sledziowska M, Llinares-Benadero C, Griffiths J, Mire E, Martinez-Garay I
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Centrosome defects cause microcephaly by activating the 53BP1-USP28-TP53 mitotic surveillance pathway.

Phan TP, Maryniak AL, Boatwright CA, Lee J, Atkins A, Tijhuis A, Spierings DC, Bazzi H, Foijer F, Jordan PW, Stracker TH, Holland AJ
The EMBO journal 2021 Jan 4;40(1):e106118

Overexpressed P75CUX1 promotes EMT in glioma infiltration by activating β-catenin.

Xu A, Wang X, Luo J, Zhou M, Yi R, Huang T, Lin J, Wu Z, Xie C, Ding S, Zeng Y, Song Y
Cell death & disease 2021 Feb 4;12(2):157

Astragalus polysaccharide regulates brown adipogenic differentiation through miR-1258-5p-modulated cut-like homeobox 1 expression.

Cao Y, Deng B, Zhang S, Gao H, Song P, Zhang J, Zhao J
Acta biochimica et biophysica Sinica 2021 Dec 8;53(12):1713-1722

miR-143 Targeting CUX1 to Regulate Proliferation of Dermal Papilla Cells in Hu Sheep.

Hu T, Huang S, Lv X, Wang S, Getachew T, Mwacharo JM, Haile A, Sun W
Genes 2021 Dec 18;12(12)

Differential Expression Levels of Sox9 in Early Neocortical Radial Glial Cells Regulate the Decision between Stem Cell Maintenance and Differentiation.

Fabra-Beser J, Alves Medeiros de Araujo J, Marques-Coelho D, Goff LA, Costa MR, Müller U, Gil-Sanz C
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Aug 18;41(33):6969-6986

ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.

Medeiros de Araújo JA, Barão S, Mateos-White I, Espinosa A, Costa MR, Gil-Sanz C, Müller U
Development (Cambridge, England) 2021 Aug 15;148(16)

Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia.

Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella JF, Thomas P, Sauvageau G, Adams DJ, Wong CC
Nature communications 2021 Apr 30;12(1):2482

AIF3 splicing switch triggers neurodegeneration.

Liu S, Zhou M, Ruan Z, Wang Y, Chang C, Sasaki M, Rajaram V, Lemoff A, Nambiar K, Wang JE, Hatanpaa KJ, Luo W, Dawson TM, Dawson VL, Wang Y
Molecular neurodegeneration 2021 Apr 14;16(1):25

Liquid Biopsy of Extracellular Vesicle-Derived miR-193a-5p in Colorectal Cancer and Discovery of Its Tumor-Suppressor Functions.

Wei R, Chen L, Qin D, Guo Q, Zhu S, Li P, Min L, Zhang S
Frontiers in oncology 2020;10:1372

hGFAP-Positive Stem Cells Depend on Brg1 for Proper Formation of Cerebral and Cerebellar Structures.

Holdhof D, Schoof M, Hellwig M, Holdhof NH, Niesen J, Schüller U
Cerebral cortex (New York, N.Y. : 1991) 2020 Mar 14;30(3):1382-1392

Reversing a model of Parkinson's disease with in situ converted nigral neurons.

Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD
Nature 2020 Jun;582(7813):550-556

The basic helix-loop-helix transcription factor TCF4 impacts brain architecture as well as neuronal morphology and differentiation.

Schoof M, Hellwig M, Harrison L, Holdhof D, Lauffer MC, Niesen J, Virdi S, Indenbirken D, Schüller U
The European journal of neuroscience 2020 Jun;51(11):2219-2235

PRISM: A Progenitor-Restricted Intersectional Fate Mapping Approach Redefines Forebrain Lineages.

Poulin JF, Luppi MP, Hofer C, Caronia G, Hsu PK, Chan CS, Awatramani R
Developmental cell 2020 Jun 22;53(6):740-753.e3

Large-Area Fluorescence and Electron Microscopic Correlative Imaging With Multibeam Scanning Electron Microscopy.

Shibata S, Iseda T, Mitsuhashi T, Oka A, Shindo T, Moritoki N, Nagai T, Otsubo S, Inoue T, Sasaki E, Akazawa C, Takahashi T, Schalek R, Lichtman JW, Okano H
Frontiers in neural circuits 2019;13:29

TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.

Ivanova EL, Gilet JG, Sulimenko V, Duchon A, Rudolf G, Runge K, Collins SC, Asselin L, Broix L, Drouot N, Tilly P, Nusbaum P, Vincent A, Magnant W, Skory V, Birling MC, Pavlovic G, Godin JD, Yalcin B, Hérault Y, Dráber P, Chelly J, Hinckelmann MV
Nature communications 2019 May 13;10(1):2129

A trap mutant reveals the physiological client spectrum of TRC40.

Coy-Vergara J, Rivera-Monroy J, Urlaub H, Lenz C, Schwappach B
Journal of cell science 2019 Jul 1;132(13)

Upregulated Expression of CUX1 Correlates with Poor Prognosis in Glioma Patients: a Bioinformatic Analysis.

Wu X, Feng F, Yang C, Zhang M, Cheng Y, Zhao Y, Wang Y, Che F, Zhang J, Heng X
Journal of molecular neuroscience : MN 2019 Dec;69(4):527-537

Loss of homeoprotein Msx1 and Msx2 leading to athletic and kinematic impairment related to the increasing neural excitability of neurons in aberrant neocortex in mice.

Yu B, Jin Y, Shen Y, Yang Y, Wang G, Zhu H, Yu Y, Wang J
Biochemical and biophysical research communications 2019 Aug 13;516(1):229-235

Inactivating CUX1 mutations promote tumorigenesis.

Wong CC, Martincorena I, Rust AG, Rashid M, Alifrangis C, Alexandrov LB, Tiffen JC, Kober C, Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium, Green AR, Massie CE, Nangalia J, Lempidaki S, Döhner H, Döhner K, Bray SJ, McDermott U, Papaemmanuil E, Campbell PJ, Adams DJ
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Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human brain tissue were subjected to SDS PAGE followed by western blot with 11733-1-AP(CUX1 antibody) at dilution of 1:2000
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using CUX1 antibody 11733-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line