12-4776-42
antibody from Invitrogen Antibodies
Targeting: FOXP3
AIID, DIETER, IPEX, JM2, PIDX, SCURFIN, XPID
Antibody data
- Antibody Data
- Antigen structure
- References [145]
- Comments [0]
- Validations
- Flow cytometry [2]
- Other assay [22]
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Validation data
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- Product number
- 12-4776-42 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- FOXP3 Monoclonal Antibody (PCH101), PE, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: eBioscience offers a panel of monoclonal antibodies to different epitopes of human Foxp3, providing useful tools for investigating the complete expression pattern of Foxp3 at the protein level, and discerning the precise subsets of Foxp3^+ cells.
- Conjugate
- Yellow dye
- Antibody clone number
- PCH101
- Concentration
- 5 µL/Test
Submitted references Heterozygous premature termination in zinc-finger domain of Krüppel-like factor 2 gene associates with dysregulated immunity.
Quantitative genome-scale metabolic modeling of human CD4(+) T cell differentiation reveals subset-specific regulation of glycosphingolipid pathways.
Taurine promotes the production of CD4(+)CD25(+)FOXP3(+) Treg cells through regulating IL-35/STAT1 pathway in a mouse allergic rhinitis model.
Potential of neutrophil to lymphocyte ratio in predicting sustained remission in rheumatoid arthritis compared to other immune activation markers.
Comparative Study of Immunomodulatory Agents to Induce Human T Regulatory (Treg) Cells: Preferential Treg-Stimulatory Effect of Prednisolone and Rapamycin.
Changes in lung immune cells related to clinical outcome during treatment with infliximab for sarcoidosis.
Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4(+) T Cells.
Role of Vitamins A and D in BCR-ABL Arf(-/-) Acute Lymphoblastic Leukemia.
The effect of everolimus and low-dose cyclophosphamide on immune cell subsets in patients with metastatic renal cell carcinoma: results from a phase I clinical trial.
T-Lymphocyte Subset Distribution and Activity in Patients With Glaucoma.
Bioinformatic analysis of peripheral blood RNA-sequencing sensitively detects the cause of late graft loss following overt hyperglycemia in pig-to-nonhuman primate islet xenotransplantation.
Regulatory T cells from patients with end-stage organ disease can be isolated, expanded and cryopreserved according good manufacturing practice improving their function.
The Effect of Age on the Immunogenicity of the Live Attenuated Zoster Vaccine Is Predicted by Baseline Regulatory T Cells and Varicella-Zoster Virus-Specific T Cell Immunity.
Human Immunodeficiency Virus Type-1 Elite Controllers Maintain Low Co-Expression of Inhibitory Receptors on CD4+ T Cells.
The Genetic Polymorphisms of NLRP3 Inflammasome Associated with T Helper Cells in Patients with Multiple Myeloma.
Mesenchymal stromal cells from myelodysplastic and acute myeloid leukemia patients display in vitro reduced proliferative potential and similar capacity to support leukemia cell survival.
CD226 opposes TIGIT to disrupt Tregs in melanoma.
Vitamin D supplementation during pregnancy: Effect on the neonatal immune system in a randomized controlled trial.
IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells.
A highly potent and selective inhibitor Roxyl-WL targeting IDO1 promotes immune response against melanoma.
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.
Differences in Peripheral Blood Lymphocytes between Brand-Name and Generic Tacrolimus Used in Stable Liver Transplant Recipients.
Cytomegalovirus infection in HIV-infected and uninfected individuals is characterized by circulating regulatory T cells of unconstrained antigenic specificity.
Decidual T Cells Exhibit a Highly Differentiated Phenotype and Demonstrate Potential Fetal Specificity and a Strong Transcriptional Response to IFN.
Bilirubin suppresses Th17 immunity in colitis by upregulating CD39.
TGF-beta/atRA-induced Tregs express a selected set of microRNAs involved in the repression of transcripts related to Th17 differentiation.
Analysis of long term CD4+CD25highCD127- T-reg cells kinetics in peripheral blood of lung transplant recipients.
HDAC inhibition potentiates immunotherapy in triple negative breast cancer.
Therapeutic immune monitoring of CD4(+)CD25(+) T cells in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors.
Augmented Th17-type immune responses in preterm neonates exposed to histologic chorioamnionitis.
Blocking the recruitment of naive CD4(+) T cells reverses immunosuppression in breast cancer.
Human ectonucleotidase-expressing CD25(high) Th17 cells accumulate in breast cancer tumors and exert immunosuppressive functions.
Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy.
Regulatory T Cells and Vitamin D Status in Children with Chronic Autoimmune Thyroiditis.
FOXP3(+) associated with the pro-inflammatory regulatory T and T helper 17 effector cells in asthma patients.
Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy.
Earlier infantile immune maturation is related to higher DTP vaccine responses in children.
Dexamethasone co-medication in cancer patients undergoing chemotherapy causes substantial immunomodulatory effects with implications for chemo-immunotherapy strategies.
Equilibrium of Treg/Th17 cells of peripheral blood in syphilitic patients with sero-resistance.
Regulatory T Cells in Patients with Idiopathic Thrombocytopenic Purpura.
CCL20-CCR6 Cytokine Network Facilitate Treg Activity in Advanced Grades and Metastatic Variants of Hepatocellular Carcinoma.
Function of Treg Cells Decreased in Patients With Systemic Lupus Erythematosus Due To the Effect of Prolactin.
Pulmonary sarcoidosis is associated with high-level inducible co-stimulator (ICOS) expression on lung regulatory T cells--possible implications for the ICOS/ICOS-ligand axis in disease course and resolution.
The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements.
Human Head and Neck Squamous Cell Carcinoma-Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells.
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
Development of Type 2, But Not Type 1, Leprosy Reactions is Associated with a Severe Reduction of Circulating and In situ Regulatory T-Cells.
Delayed adaptive immunity is related to higher MMR vaccine-induced antibody titers in children.
Distribution of Peripheral Memory T Follicular Helper Cells in Patients with Schistosomiasis Japonica.
Durable complete responses off all treatment in patients with metastatic malignant melanoma after sequential immunotherapy followed by a finite course of BRAF inhibitor therapy.
Enhancement of the immunoregulatory potency of mesenchymal stromal cells by treatment with immunosuppressive drugs.
Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry.
Increased Intraepithelial Vα24 Invariant NKT Cells in the Celiac Duodenum.
Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants.
The immunosuppressive enzyme IL4I1 promotes FoxP3(+) regulatory T lymphocyte differentiation.
Improved Natural Killer cell activity and retained anti-tumor CD8(+) T cell responses contribute to the induction of a pathological complete response in HER2-positive breast cancer patients undergoing neoadjuvant chemotherapy.
Decline of FoxP3+ Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria.
CD4+CD25hiFOXP3+ Regulatory T Cells and Cytokine Responses in Human Schistosomiasis before and after Treatment with Praziquantel.
An increased abundance of tumor-infiltrating regulatory T cells is correlated with the progression and prognosis of pancreatic ductal adenocarcinoma.
Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production.
Regulatory T cells expanded from HIV-1-infected individuals maintain phenotype, TCR repertoire and suppressive capacity.
A method for conducting suppression assays using small numbers of tissue-isolated regulatory T cells.
Adoptive immunotherapy with MUC1-mRNA transfected dendritic cells and cytotoxic lymphocytes plus gemcitabine for unresectable pancreatic cancer.
High proportions of FOXP3(+) CD25(high) T cells in neonates are positively associated with allergic sensitization later in childhood.
The disturbance of TH17-Treg cell balance in adenomyosis.
Elevated levels of CD4(+)CD25(+)FoxP3(+) T cells in systemic sclerosis patients contribute to the secretion of IL-17 and immunosuppression dysfunction.
Human T cells upregulate CD69 after coculture with xenogeneic genetically-modified pig mesenchymal stromal cells.
Protein kinase C inhibitor generates stable human tolerogenic dendritic cells.
Cross talk between follicular Th cells and tumor cells in human follicular lymphoma promotes immune evasion in the tumor microenvironment.
Ribavirin Does Not Impair the Suppressive Activity of Foxp3(+)CD4(+)CD25(+) Regulatory T Cells.
Subinfectious hepatitis C virus exposures suppress T cell responses against subsequent acute infection.
Lymphocyte subpopulations in lymph nodes and peripheral blood: a comparison between patients with stable angina and acute coronary syndrome.
Seasonal variation in vitamin D₃ levels is paralleled by changes in the peripheral blood human T cell compartment.
The impact of vitamin D deficiency on immune T cells in asthmatic children: a case-control study.
Impaired function of regulatory T cells in cord blood of children of allergic mothers.
Infant B cell memory differentiation and early gut bacterial colonization.
Programmed death-1+ T cells and regulatory T cells are enriched in tumor-involved lymph nodes and associated with aggressive features in papillary thyroid cancer.
Induction of endometriosis alters the peripheral and endometrial regulatory T cell population in the non-human primate.
Whole-body UVB irradiation during allogeneic hematopoietic cell transplantation is safe and decreases acute graft-versus-host disease.
Prolactin down-regulates CD4+CD25hiCD127low/- regulatory T cell function in humans.
Phenotypic complexity of T regulatory subsets in patients with B-chronic lymphocytic leukemia.
Absolute lymphocyte count is associated with survival in ovarian cancer independent of tumor-infiltrating lymphocytes.
OMIP-006: phenotypic subset analysis of human T regulatory cells via polychromatic flow cytometry.
Naive T cells are dispensable for memory CD4+ T cell homeostasis in progressive simian immunodeficiency virus infection.
Frequency of circulating regulatory T cells increases during chronic HIV infection and is largely controlled by highly active antiretroviral therapy.
Choice of resident costimulatory molecule can influence cell fate in human naïve CD4+ T cell differentiation.
A different immunologic profile characterizes patients with HER-2-overexpressing and HER-2-negative locally advanced breast cancer: implications for immune-based therapies.
Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses.
CD4+ T cells, including Th17 and cycling subsets, are intact in the gut mucosa of HIV-1-infected long-term nonprogressors.
Separation of human CD4+CD39+ T cells by magnetic beads reveals two phenotypically and functionally different subsets.
Anticardiac myosin immunity and chronic allograft vasculopathy in heart transplant recipients.
Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies.
Hypoxia potentiates glioma-mediated immunosuppression.
miR-155, a Modulator of FOXO3a Protein Expression, Is Underexpressed and Cannot Be Upregulated by Stimulation of HOZOT, a Line of Multifunctional Treg.
Higher proportions of circulating FOXP3+ and CTLA-4+ regulatory T cells are associated with lower fractions of memory CD4+ T cells in infants.
T cells expressing constitutively active Akt resist multiple tumor-associated inhibitory mechanisms.
Differential but direct abolishment of human regulatory T cell suppressive capacity by various TLR2 ligands.
Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.
PGE(2) contributes to TGF-beta induced T regulatory cell function in human non-small cell lung cancer.
In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia.
CD40 signalling induces IL-10-producing, tolerogenic dendritic cells.
Effects of nilotinib on regulatory T cells: the dose matters.
Glioma-associated cancer-initiating cells induce immunosuppression.
Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.
Photodepletion differentially affects CD4+ Tregs versus CD4+ effector T cells from patients with chronic graft-versus-host disease.
Peroxisome proliferator-activated receptor α and γ agonists together with TGF-β convert human CD4+CD25- T cells into functional Foxp3+ regulatory T cells.
Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis.
FOXP3+ regulatory T cells and T helper 1, T helper 2, and T helper 17 cells in human early pregnancy decidua.
Fludarabine modulates immune response and extends in vivo survival of adoptively transferred CD8 T cells in patients with metastatic melanoma.
Regulatory T cell (Treg) subsets return in patients with refractory lupus following stem cell transplantation, and TGF-beta-producing CD8+ Treg cells are associated with immunological remission of lupus.
The role of the CD58 locus in multiple sclerosis.
Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells.
Determinants of in vitro expansion of different human virus-specific FoxP3+ regulatory CD8+ T cells in chronic hepatitis C virus infection.
Intratumoral immune cell infiltrates, FoxP3, and indoleamine 2,3-dioxygenase in patients with melanoma undergoing CTLA4 blockade.
Unique phenotype of human tonsillar and in vitro-induced FOXP3+CD8+ T cells.
The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4+CD25+Foxp3+ regulatory T cells.
CD13+CD4+CD25hi regulatory T cells exhibit higher suppressive function and increase with tumor stage in non-small cell lung cancer patients.
Immune mediated autologous cytotoxicity against hematopoietic precursor cells in patients with myelodysplastic syndrome.
Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria.
Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation.
Naturally occurring regulatory T cells show reduced sensitivity toward oxidative stress-induced cell death.
The effects of trastuzumab on the CD4+CD25+FoxP3+ and CD4+IL17A+ T-cell axis in patients with breast cancer.
Comparative study of regulatory T cell function of human CD25CD4 T cells from thymocytes, cord blood, and adult peripheral blood.
Expression and function of PDCD1 at the human maternal-fetal interface.
Reciprocal CD4+ T-cell balance of effector CD62Llow CD4+ and CD62LhighCD25+ CD4+ regulatory T cells in small cell lung cancer reflects disease stage.
Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin's lymphoma cells mediates Up-regulation of CCL20 and the migration of regulatory T cells.
IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes.
Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype.
Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells.
Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta.
IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin.
GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells.
Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25- T cells.
FOXP3 regulates TLR10 expression in human T regulatory cells.
IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo.
Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART.
Isolation of CD4+CD25+ regulatory T cells for clinical trials.
IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients.
Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C.
Transient accumulation of human mature thymocytes and regulatory T cells with CD28 superagonist in "human immune system" Rag2(-/-)gammac(-/-) mice.
Depletion of alloreactive T cells via CD69: implications on antiviral, antileukemic and immunoregulatory T lymphocytes.
Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion.
Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells.
Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells.
Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4+CD25+ T regulatory cells.
Pernaa N, Keskitalo S, Chowdhury I, Nissinen A, Glumoff V, Keski-Filppula R, Junttila J, Eklund KK, Santaniemi W, Siitonen S, Seppänen MR, Vähäsalo P, Varjosalo M, Åström P, Hautala T
Frontiers in immunology 2022;13:819929
Frontiers in immunology 2022;13:819929
Quantitative genome-scale metabolic modeling of human CD4(+) T cell differentiation reveals subset-specific regulation of glycosphingolipid pathways.
Sen P, Andrabi SBA, Buchacher T, Khan MM, Kalim UU, Lindeman TM, Alves MA, Hinkkanen V, Kemppainen E, Dickens AM, Rasool O, Hyötyläinen T, Lahesmaa R, Orešič M
Cell reports 2021 Nov 9;37(6):109973
Cell reports 2021 Nov 9;37(6):109973
Taurine promotes the production of CD4(+)CD25(+)FOXP3(+) Treg cells through regulating IL-35/STAT1 pathway in a mouse allergic rhinitis model.
Zhou J, Lu Y, Wu W, Feng Y
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2021 Jun 19;17(1):59
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2021 Jun 19;17(1):59
Potential of neutrophil to lymphocyte ratio in predicting sustained remission in rheumatoid arthritis compared to other immune activation markers.
Chandrashekara S, Lingaraju DC, Renuka P, Anupama KR
The Indian journal of medical research 2020 Sep;152(3):234-243
The Indian journal of medical research 2020 Sep;152(3):234-243
Comparative Study of Immunomodulatory Agents to Induce Human T Regulatory (Treg) Cells: Preferential Treg-Stimulatory Effect of Prednisolone and Rapamycin.
Janyst M, Kaleta B, Janyst K, Zagożdżon R, Kozlowska E, Lasek W
Archivum immunologiae et therapiae experimentalis 2020 Jun 12;68(4):20
Archivum immunologiae et therapiae experimentalis 2020 Jun 12;68(4):20
Changes in lung immune cells related to clinical outcome during treatment with infliximab for sarcoidosis.
Kullberg S, Rivera NV, Abo Al Hayja M, Grunewald J, Eklund A
Clinical and experimental immunology 2020 Jul;201(1):85-93
Clinical and experimental immunology 2020 Jul;201(1):85-93
Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4(+) T Cells.
Śledzińska A, Vila de Mucha M, Bergerhoff K, Hotblack A, Demane DF, Ghorani E, Akarca AU, Marzolini MAV, Solomon I, Vargas FA, Pule M, Ono M, Seddon B, Kassiotis G, Ariyan CE, Korn T, Marafioti T, Lord GM, Stauss H, Jenner RG, Peggs KS, Quezada SA
Immunity 2020 Jan 14;52(1):151-166.e6
Immunity 2020 Jan 14;52(1):151-166.e6
Role of Vitamins A and D in BCR-ABL Arf(-/-) Acute Lymphoblastic Leukemia.
Annu K, Cline C, Yasuda K, Ganguly S, Pesch A, Cooper B, Janke L, Payton M, Mukherjee K, Surman SL, Hurwitz JL, Schuetz EG
Scientific reports 2020 Feb 11;10(1):2359
Scientific reports 2020 Feb 11;10(1):2359
The effect of everolimus and low-dose cyclophosphamide on immune cell subsets in patients with metastatic renal cell carcinoma: results from a phase I clinical trial.
Huijts CM, Lougheed SM, Bodalal Z, van Herpen CM, Hamberg P, Tascilar M, Haanen JB, Verheul HM, de Gruijl TD, van der Vliet HJ, Dutch WIN-O Consortium
Cancer immunology, immunotherapy : CII 2019 Mar;68(3):503-515
Cancer immunology, immunotherapy : CII 2019 Mar;68(3):503-515
T-Lymphocyte Subset Distribution and Activity in Patients With Glaucoma.
Yang X, Zeng Q, Göktas E, Gopal K, Al-Aswad L, Blumberg DM, Cioffi GA, Liebmann JM, Tezel G
Investigative ophthalmology & visual science 2019 Mar 1;60(4):877-888
Investigative ophthalmology & visual science 2019 Mar 1;60(4):877-888
Bioinformatic analysis of peripheral blood RNA-sequencing sensitively detects the cause of late graft loss following overt hyperglycemia in pig-to-nonhuman primate islet xenotransplantation.
Kim HJ, Moon JH, Chung H, Shin JS, Kim B, Kim JM, Kim JS, Yoon IH, Min BH, Kang SJ, Kim YH, Jo K, Choi J, Chae H, Lee WW, Kim S, Park CG
Scientific reports 2019 Dec 11;9(1):18835
Scientific reports 2019 Dec 11;9(1):18835
Regulatory T cells from patients with end-stage organ disease can be isolated, expanded and cryopreserved according good manufacturing practice improving their function.
Ulbar F, Montemurro T, Jofra T, Capri M, Comai G, Bertuzzo V, Lavazza C, Mandelli A, Viganò M, Budelli S, Bacalini MG, Pirazzini C, Garagnani P, Giudice V, Sollazzo D, Curti A, Arpinati M, La Manna G, Cescon M, Pinna AD, Franceschi C, Battaglia M, Giordano R, Catani L, Lemoli RM
Journal of translational medicine 2019 Aug 5;17(1):250
Journal of translational medicine 2019 Aug 5;17(1):250
The Effect of Age on the Immunogenicity of the Live Attenuated Zoster Vaccine Is Predicted by Baseline Regulatory T Cells and Varicella-Zoster Virus-Specific T Cell Immunity.
Weinberg A, Pang L, Johnson MJ, Caldas Y, Cho A, Tovar-Salazar A, Canniff J, Schmader KE, Popmihajlov Z, Levin MJ
Journal of virology 2019 Aug 1;93(15)
Journal of virology 2019 Aug 1;93(15)
Human Immunodeficiency Virus Type-1 Elite Controllers Maintain Low Co-Expression of Inhibitory Receptors on CD4+ T Cells.
Noyan K, Nguyen S, Betts MR, Sönnerborg A, Buggert M
Frontiers in immunology 2018;9:19
Frontiers in immunology 2018;9:19
The Genetic Polymorphisms of NLRP3 Inflammasome Associated with T Helper Cells in Patients with Multiple Myeloma.
Zhao X, Hua M, Yan S, Yu J, Han F, Zhong C, Wang R, Zhang C, Hou M, Ma D
Journal of immunology research 2018;2018:7569809
Journal of immunology research 2018;2018:7569809
Mesenchymal stromal cells from myelodysplastic and acute myeloid leukemia patients display in vitro reduced proliferative potential and similar capacity to support leukemia cell survival.
Corradi G, Baldazzi C, Očadlíková D, Marconi G, Parisi S, Testoni N, Finelli C, Cavo M, Curti A, Ciciarello M
Stem cell research & therapy 2018 Oct 25;9(1):271
Stem cell research & therapy 2018 Oct 25;9(1):271
CD226 opposes TIGIT to disrupt Tregs in melanoma.
Fourcade J, Sun Z, Chauvin JM, Ka M, Davar D, Pagliano O, Wang H, Saada S, Menna C, Amin R, Sander C, Kirkwood JM, Korman AJ, Zarour HM
JCI insight 2018 Jul 26;3(14)
JCI insight 2018 Jul 26;3(14)
Vitamin D supplementation during pregnancy: Effect on the neonatal immune system in a randomized controlled trial.
Hornsby E, Pfeffer PE, Laranjo N, Cruikshank W, Tuzova M, Litonjua AA, Weiss ST, Carey VJ, O'Connor G, Hawrylowicz C
The Journal of allergy and clinical immunology 2018 Jan;141(1):269-278.e1
The Journal of allergy and clinical immunology 2018 Jan;141(1):269-278.e1
IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells.
Hsieh WC, Hsu TS, Chang YJ, Lai MZ
Nature communications 2018 Jan 31;9(1):463
Nature communications 2018 Jan 31;9(1):463
A highly potent and selective inhibitor Roxyl-WL targeting IDO1 promotes immune response against melanoma.
Xu G, Wang T, Li Y, Huang Z, Wang X, Zheng J, Yang S, Fan Y, Xiang R
Journal of enzyme inhibition and medicinal chemistry 2018 Dec;33(1):1089-1094
Journal of enzyme inhibition and medicinal chemistry 2018 Dec;33(1):1089-1094
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.
Arce Vargas F, Furness AJS, Litchfield K, Joshi K, Rosenthal R, Ghorani E, Solomon I, Lesko MH, Ruef N, Roddie C, Henry JY, Spain L, Ben Aissa A, Georgiou A, Wong YNS, Smith M, Strauss D, Hayes A, Nicol D, O'Brien T, Mårtensson L, Ljungars A, Teige I, Frendéus B, TRACERx Melanoma, TRACERx Renal, TRACERx Lung consortia, Pule M, Marafioti T, Gore M, Larkin J, Turajlic S, Swanton C, Peggs KS, Quezada SA
Cancer cell 2018 Apr 9;33(4):649-663.e4
Cancer cell 2018 Apr 9;33(4):649-663.e4
Differences in Peripheral Blood Lymphocytes between Brand-Name and Generic Tacrolimus Used in Stable Liver Transplant Recipients.
Kim JM, Kwon CHD, Joh JW, Sinn DH, Choi GS, Park JB, Kang ES, Lee SK
Medical principles and practice : international journal of the Kuwait University, Health Science Centre 2017;26(3):221-228
Medical principles and practice : international journal of the Kuwait University, Health Science Centre 2017;26(3):221-228
Cytomegalovirus infection in HIV-infected and uninfected individuals is characterized by circulating regulatory T cells of unconstrained antigenic specificity.
Tovar-Salazar A, Weinberg A
PloS one 2017;12(7):e0180691
PloS one 2017;12(7):e0180691
Decidual T Cells Exhibit a Highly Differentiated Phenotype and Demonstrate Potential Fetal Specificity and a Strong Transcriptional Response to IFN.
Powell RM, Lissauer D, Tamblyn J, Beggs A, Cox P, Moss P, Kilby MD
Journal of immunology (Baltimore, Md. : 1950) 2017 Nov 15;199(10):3406-3417
Journal of immunology (Baltimore, Md. : 1950) 2017 Nov 15;199(10):3406-3417
Bilirubin suppresses Th17 immunity in colitis by upregulating CD39.
Longhi MS, Vuerich M, Kalbasi A, Kenison JE, Yeste A, Csizmadia E, Vaughn B, Feldbrugge L, Mitsuhashi S, Wegiel B, Otterbein L, Moss A, Quintana FJ, Robson SC
JCI insight 2017 May 4;2(9)
JCI insight 2017 May 4;2(9)
TGF-beta/atRA-induced Tregs express a selected set of microRNAs involved in the repression of transcripts related to Th17 differentiation.
Schiavinato JLDS, Haddad R, Saldanha-Araujo F, Baiochi J, Araujo AG, Santos Scheucher P, Covas DT, Zago MA, Panepucci RA
Scientific reports 2017 Jun 15;7(1):3627
Scientific reports 2017 Jun 15;7(1):3627
Analysis of long term CD4+CD25highCD127- T-reg cells kinetics in peripheral blood of lung transplant recipients.
Piloni D, Morosini M, Magni S, Balderacchi A, Scudeller L, Cova E, Oggionni T, Stella G, Tinelli C, Antonacci F, D'Armini AM, Meloni F
BMC pulmonary medicine 2017 Jul 18;17(1):102
BMC pulmonary medicine 2017 Jul 18;17(1):102
HDAC inhibition potentiates immunotherapy in triple negative breast cancer.
Terranova-Barberio M, Thomas S, Ali N, Pawlowska N, Park J, Krings G, Rosenblum MD, Budillon A, Munster PN
Oncotarget 2017 Dec 26;8(69):114156-114172
Oncotarget 2017 Dec 26;8(69):114156-114172
Therapeutic immune monitoring of CD4(+)CD25(+) T cells in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors.
Lu Z, Xu N, Zhou X, Gao G, Li L, Huang J, Li Y, Lu Q, He B, Pan C, Liu X
Oncology letters 2017 Aug;14(2):1363-1372
Oncology letters 2017 Aug;14(2):1363-1372
Augmented Th17-type immune responses in preterm neonates exposed to histologic chorioamnionitis.
Rito DC, Viehl LT, Buchanan PM, Haridas S, Koenig JM
Pediatric research 2017 Apr;81(4):639-645
Pediatric research 2017 Apr;81(4):639-645
Blocking the recruitment of naive CD4(+) T cells reverses immunosuppression in breast cancer.
Su S, Liao J, Liu J, Huang D, He C, Chen F, Yang L, Wu W, Chen J, Lin L, Zeng Y, Ouyang N, Cui X, Yao H, Su F, Huang JD, Lieberman J, Liu Q, Song E
Cell research 2017 Apr;27(4):461-482
Cell research 2017 Apr;27(4):461-482
Human ectonucleotidase-expressing CD25(high) Th17 cells accumulate in breast cancer tumors and exert immunosuppressive functions.
Thibaudin M, Chaix M, Boidot R, Végran F, Derangère V, Limagne E, Berger H, Ladoire S, Apetoh L, Ghiringhelli F
Oncoimmunology 2016;5(1):e1055444
Oncoimmunology 2016;5(1):e1055444
Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy.
Wang L, Zhang Y, Li H, Hong J, Chen X, Li M, Bai W, Wang J, Liu Y, Wu M
Stem cells international 2016;2016:9165267
Stem cells international 2016;2016:9165267
Regulatory T Cells and Vitamin D Status in Children with Chronic Autoimmune Thyroiditis.
Şıklar Z, Karataş D, Doğu F, Hacıhamdioğlu B, İkincioğulları A, Berberoğlu M
Journal of clinical research in pediatric endocrinology 2016 Sep 1;8(3):276-81
Journal of clinical research in pediatric endocrinology 2016 Sep 1;8(3):276-81
FOXP3(+) associated with the pro-inflammatory regulatory T and T helper 17 effector cells in asthma patients.
Zhang JG, Chen XJ, Liu T, Jiang SJ
Experimental and therapeutic medicine 2016 Oct;12(4):2753-2758
Experimental and therapeutic medicine 2016 Oct;12(4):2753-2758
Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy.
Williams GS, Mistry B, Guillard S, Ulrichsen JC, Sandercock AM, Wang J, González-Muñoz A, Parmentier J, Black C, Soden J, Freeth J, Jovanović J, Leyland R, Al-Lamki RS, Leishman AJ, Rust SJ, Stewart R, Jermutus L, Bradley JR, Bedian V, Valge-Archer V, Minter R, Wilkinson RW
Oncotarget 2016 Oct 18;7(42):68278-68291
Oncotarget 2016 Oct 18;7(42):68278-68291
Earlier infantile immune maturation is related to higher DTP vaccine responses in children.
Strömbeck A, Lundell AC, Nordström I, Andersson K, Adlerberth I, Wold AE, Rudin A
Clinical & translational immunology 2016 Mar;5(3):e65
Clinical & translational immunology 2016 Mar;5(3):e65
Dexamethasone co-medication in cancer patients undergoing chemotherapy causes substantial immunomodulatory effects with implications for chemo-immunotherapy strategies.
Cook AM, McDonnell AM, Lake RA, Nowak AK
Oncoimmunology 2016 Mar;5(3):e1066062
Oncoimmunology 2016 Mar;5(3):e1066062
Equilibrium of Treg/Th17 cells of peripheral blood in syphilitic patients with sero-resistance.
Zhao J, Ma J, Zhang X, Li Q, Yang X
Experimental and therapeutic medicine 2016 Jun;11(6):2300-2304
Experimental and therapeutic medicine 2016 Jun;11(6):2300-2304
Regulatory T Cells in Patients with Idiopathic Thrombocytopenic Purpura.
Akyol Erikçi A, Karagöz B, Bilgi O
Turkish journal of haematology : official journal of Turkish Society of Haematology 2016 Jun 5;33(2):153-5
Turkish journal of haematology : official journal of Turkish Society of Haematology 2016 Jun 5;33(2):153-5
CCL20-CCR6 Cytokine Network Facilitate Treg Activity in Advanced Grades and Metastatic Variants of Hepatocellular Carcinoma.
Li WM, Liu HR
Scandinavian journal of immunology 2016 Jan;83(1):33-7
Scandinavian journal of immunology 2016 Jan;83(1):33-7
Function of Treg Cells Decreased in Patients With Systemic Lupus Erythematosus Due To the Effect of Prolactin.
Legorreta-Haquet MV, Chávez-Rueda K, Chávez-Sánchez L, Cervera-Castillo H, Zenteno-Galindo E, Barile-Fabris L, Burgos-Vargas R, Álvarez-Hernández E, Blanco-Favela F
Medicine 2016 Feb;95(5):e2384
Medicine 2016 Feb;95(5):e2384
Pulmonary sarcoidosis is associated with high-level inducible co-stimulator (ICOS) expression on lung regulatory T cells--possible implications for the ICOS/ICOS-ligand axis in disease course and resolution.
Sakthivel P, Grunewald J, Eklund A, Bruder D, Wahlström J
Clinical and experimental immunology 2016 Feb;183(2):294-306
Clinical and experimental immunology 2016 Feb;183(2):294-306
The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements.
Procaccini C, Carbone F, Di Silvestre D, Brambilla F, De Rosa V, Galgani M, Faicchia D, Marone G, Tramontano D, Corona M, Alviggi C, Porcellini A, La Cava A, Mauri P, Matarese G
Immunity 2016 Feb 16;44(2):406-21
Immunity 2016 Feb 16;44(2):406-21
Human Head and Neck Squamous Cell Carcinoma-Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells.
Younis RH, Han KL, Webb TJ
Journal of immunology (Baltimore, Md. : 1950) 2016 Feb 1;196(3):1419-29
Journal of immunology (Baltimore, Md. : 1950) 2016 Feb 1;196(3):1419-29
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
Clever D, Roychoudhuri R, Constantinides MG, Askenase MH, Sukumar M, Klebanoff CA, Eil RL, Hickman HD, Yu Z, Pan JH, Palmer DC, Phan AT, Goulding J, Gattinoni L, Goldrath AW, Belkaid Y, Restifo NP
Cell 2016 Aug 25;166(5):1117-1131.e14
Cell 2016 Aug 25;166(5):1117-1131.e14
Development of Type 2, But Not Type 1, Leprosy Reactions is Associated with a Severe Reduction of Circulating and In situ Regulatory T-Cells.
Vieira AP, Trindade MÂ, Pagliari C, Avancini J, Sakai-Valente NY, Duarte AJ, Benard G
The American journal of tropical medicine and hygiene 2016 Apr;94(4):721-7
The American journal of tropical medicine and hygiene 2016 Apr;94(4):721-7
Delayed adaptive immunity is related to higher MMR vaccine-induced antibody titers in children.
Strömbeck A, Lundell AC, Nordström I, Andersson K, Adlerberth I, Wold AE, Rudin A
Clinical & translational immunology 2016 Apr;5(4):e75
Clinical & translational immunology 2016 Apr;5(4):e75
Distribution of Peripheral Memory T Follicular Helper Cells in Patients with Schistosomiasis Japonica.
Chen X, Li W, Zhang Y, Song X, Xu L, Xu Z, Zhou S, Zhu J, Jin X, Liu F, Chen G, Su C
PLoS neglected tropical diseases 2015;9(8):e0004015
PLoS neglected tropical diseases 2015;9(8):e0004015
Durable complete responses off all treatment in patients with metastatic malignant melanoma after sequential immunotherapy followed by a finite course of BRAF inhibitor therapy.
Wyluda EJ, Cheng J, Schell TD, Haley JS, Mallon C, Neves RI, Robertson G, Sivik J, Mackley H, Talamo G, Drabick JJ
Cancer biology & therapy 2015;16(5):662-70
Cancer biology & therapy 2015;16(5):662-70
Enhancement of the immunoregulatory potency of mesenchymal stromal cells by treatment with immunosuppressive drugs.
Girdlestone J, Pido-Lopez J, Srivastava S, Chai J, Leaver N, Galleu A, Lombardi G, Navarrete CV
Cytotherapy 2015 Sep;17(9):1188-99
Cytotherapy 2015 Sep;17(9):1188-99
Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry.
Santegoets SJ, Dijkgraaf EM, Battaglia A, Beckhove P, Britten CM, Gallimore A, Godkin A, Gouttefangeas C, de Gruijl TD, Koenen HJ, Scheffold A, Shevach EM, Staats J, Taskén K, Whiteside TL, Kroep JR, Welters MJ, van der Burg SH
Cancer immunology, immunotherapy : CII 2015 Oct;64(10):1271-86
Cancer immunology, immunotherapy : CII 2015 Oct;64(10):1271-86
Increased Intraepithelial Vα24 Invariant NKT Cells in the Celiac Duodenum.
Montalvillo E, Bernardo D, Martínez-Abad B, Allegretti Y, Fernández-Salazar L, Calvo C, Chirdo FG, Garrote JA, Arranz E
Nutrients 2015 Oct 30;7(11):8960-76
Nutrients 2015 Oct 30;7(11):8960-76
Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants.
De Rosa V, Galgani M, Porcellini A, Colamatteo A, Santopaolo M, Zuchegna C, Romano A, De Simone S, Procaccini C, La Rocca C, Carrieri PB, Maniscalco GT, Salvetti M, Buscarinu MC, Franzese A, Mozzillo E, La Cava A, Matarese G
Nature immunology 2015 Nov;16(11):1174-84
Nature immunology 2015 Nov;16(11):1174-84
The immunosuppressive enzyme IL4I1 promotes FoxP3(+) regulatory T lymphocyte differentiation.
Cousin C, Aubatin A, Le Gouvello S, Apetoh L, Castellano F, Molinier-Frenkel V
European journal of immunology 2015 Jun;45(6):1772-82
European journal of immunology 2015 Jun;45(6):1772-82
Improved Natural Killer cell activity and retained anti-tumor CD8(+) T cell responses contribute to the induction of a pathological complete response in HER2-positive breast cancer patients undergoing neoadjuvant chemotherapy.
Muraro E, Comaro E, Talamini R, Turchet E, Miolo G, Scalone S, Militello L, Lombardi D, Spazzapan S, Perin T, Massarut S, Crivellari D, Dolcetti R, Martorelli D
Journal of translational medicine 2015 Jun 27;13:204
Journal of translational medicine 2015 Jun 27;13:204
Decline of FoxP3+ Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria.
Boyle MJ, Jagannathan P, Farrington LA, Eccles-James I, Wamala S, McIntyre TI, Vance HM, Bowen K, Nankya F, Auma A, Nalubega M, Sikyomu E, Naluwu K, Rek J, Katureebe A, Bigira V, Kapisi J, Tappero J, Muhindo MK, Greenhouse B, Arinaitwe E, Dorsey G, Kamya MR, Feeney ME
PLoS pathogens 2015 Jul;11(7):e1005041
PLoS pathogens 2015 Jul;11(7):e1005041
CD4+CD25hiFOXP3+ Regulatory T Cells and Cytokine Responses in Human Schistosomiasis before and after Treatment with Praziquantel.
Schmiedel Y, Mombo-Ngoma G, Labuda LA, Janse JJ, de Gier B, Adegnika AA, Issifou S, Kremsner PG, Smits HH, Yazdanbakhsh M
PLoS neglected tropical diseases 2015 Aug;9(8):e0003995
PLoS neglected tropical diseases 2015 Aug;9(8):e0003995
An increased abundance of tumor-infiltrating regulatory T cells is correlated with the progression and prognosis of pancreatic ductal adenocarcinoma.
Tang Y, Xu X, Guo S, Zhang C, Tang Y, Tian Y, Ni B, Lu B, Wang H
PloS one 2014;9(3):e91551
PloS one 2014;9(3):e91551
Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production.
Lowe MM, Mold JE, Kanwar B, Huang Y, Louie A, Pollastri MP, Wang C, Patel G, Franks DG, Schlezinger J, Sherr DH, Silverstone AE, Hahn ME, McCune JM
PloS one 2014;9(2):e87877
PloS one 2014;9(2):e87877
Regulatory T cells expanded from HIV-1-infected individuals maintain phenotype, TCR repertoire and suppressive capacity.
Angin M, Klarenbeek PL, King M, Sharma SM, Moodley ES, Rezai A, Piechocka-Trocha A, Toth I, Chan AT, Goulder PJ, Ndung'u T, Kwon DS, Addo MM
PloS one 2014;9(2):e86920
PloS one 2014;9(2):e86920
A method for conducting suppression assays using small numbers of tissue-isolated regulatory T cells.
Ward ST, Li KK, Curbishley SM
MethodsX 2014;1:168-174
MethodsX 2014;1:168-174
Adoptive immunotherapy with MUC1-mRNA transfected dendritic cells and cytotoxic lymphocytes plus gemcitabine for unresectable pancreatic cancer.
Shindo Y, Hazama S, Maeda Y, Matsui H, Iida M, Suzuki N, Yoshimura K, Ueno T, Yoshino S, Sakai K, Suehiro Y, Yamasaki T, Hinoda Y, Oka M
Journal of translational medicine 2014 Jun 19;12:175
Journal of translational medicine 2014 Jun 19;12:175
High proportions of FOXP3(+) CD25(high) T cells in neonates are positively associated with allergic sensitization later in childhood.
Strömbeck A, Rabe H, Lundell AC, Andersson K, Johansen S, Adlerberth I, Wold AE, Hesselmar B, Rudin A
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2014 Jul;44(7):940-52
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2014 Jul;44(7):940-52
The disturbance of TH17-Treg cell balance in adenomyosis.
Gui T, Chen C, Zhang Z, Tang W, Qian R, Ma X, Cao P, Wan G
Fertility and sterility 2014 Feb;101(2):506-14
Fertility and sterility 2014 Feb;101(2):506-14
Elevated levels of CD4(+)CD25(+)FoxP3(+) T cells in systemic sclerosis patients contribute to the secretion of IL-17 and immunosuppression dysfunction.
Liu X, Gao N, Li M, Xu D, Hou Y, Wang Q, Zhang G, Sun Q, Zhang H, Zeng X
PloS one 2013;8(6):e64531
PloS one 2013;8(6):e64531
Human T cells upregulate CD69 after coculture with xenogeneic genetically-modified pig mesenchymal stromal cells.
Li J, Andreyev O, Chen M, Marco M, Iwase H, Long C, Ayares D, Shen Z, Cooper DK, Ezzelarab MB
Cellular immunology 2013 Sep-Oct;285(1-2):23-30
Cellular immunology 2013 Sep-Oct;285(1-2):23-30
Protein kinase C inhibitor generates stable human tolerogenic dendritic cells.
Matsumoto T, Hasegawa H, Onishi S, Ishizaki J, Suemori K, Yasukawa M
Journal of immunology (Baltimore, Md. : 1950) 2013 Sep 1;191(5):2247-57
Journal of immunology (Baltimore, Md. : 1950) 2013 Sep 1;191(5):2247-57
Cross talk between follicular Th cells and tumor cells in human follicular lymphoma promotes immune evasion in the tumor microenvironment.
Rawal S, Chu F, Zhang M, Park HJ, Nattamai D, Kannan S, Sharma R, Delgado D, Chou T, Lin HY, Baladandayuthapani V, Luong A, Vega F, Fowler N, Dong C, Davis RE, Neelapu SS
Journal of immunology (Baltimore, Md. : 1950) 2013 Jun 15;190(12):6681-93
Journal of immunology (Baltimore, Md. : 1950) 2013 Jun 15;190(12):6681-93
Ribavirin Does Not Impair the Suppressive Activity of Foxp3(+)CD4(+)CD25(+) Regulatory T Cells.
Lee J, Choi YS, Shin EC
Immune network 2013 Feb;13(1):25-9
Immune network 2013 Feb;13(1):25-9
Subinfectious hepatitis C virus exposures suppress T cell responses against subsequent acute infection.
Park SH, Veerapu NS, Shin EC, Biancotto A, McCoy JP, Capone S, Folgori A, Rehermann B
Nature medicine 2013 Dec;19(12):1638-42
Nature medicine 2013 Dec;19(12):1638-42
Lymphocyte subpopulations in lymph nodes and peripheral blood: a comparison between patients with stable angina and acute coronary syndrome.
Backteman K, Andersson C, Dahlin LG, Ernerudh J, Jonasson L
PloS one 2012;7(3):e32691
PloS one 2012;7(3):e32691
Seasonal variation in vitamin D₃ levels is paralleled by changes in the peripheral blood human T cell compartment.
Khoo AL, Koenen HJ, Chai LY, Sweep FC, Netea MG, van der Ven AJ, Joosten I
PloS one 2012;7(1):e29250
PloS one 2012;7(1):e29250
The impact of vitamin D deficiency on immune T cells in asthmatic children: a case-control study.
Maalmi H, Berraïes A, Tangour E, Ammar J, Abid H, Hamzaoui K, Hamzaoui A
Journal of asthma and allergy 2012;5:11-9
Journal of asthma and allergy 2012;5:11-9
Impaired function of regulatory T cells in cord blood of children of allergic mothers.
Hrdý J, Kocourková I, Prokešová L
Clinical and experimental immunology 2012 Oct;170(1):10-7
Clinical and experimental immunology 2012 Oct;170(1):10-7
Infant B cell memory differentiation and early gut bacterial colonization.
Lundell AC, Björnsson V, Ljung A, Ceder M, Johansen S, Lindhagen G, Törnhage CJ, Adlerberth I, Wold AE, Rudin A
Journal of immunology (Baltimore, Md. : 1950) 2012 May 1;188(9):4315-22
Journal of immunology (Baltimore, Md. : 1950) 2012 May 1;188(9):4315-22
Programmed death-1+ T cells and regulatory T cells are enriched in tumor-involved lymph nodes and associated with aggressive features in papillary thyroid cancer.
French JD, Kotnis GR, Said S, Raeburn CD, McIntyre RC Jr, Klopper JP, Haugen BR
The Journal of clinical endocrinology and metabolism 2012 Jun;97(6):E934-43
The Journal of clinical endocrinology and metabolism 2012 Jun;97(6):E934-43
Induction of endometriosis alters the peripheral and endometrial regulatory T cell population in the non-human primate.
Braundmeier A, Jackson K, Hastings J, Koehler J, Nowak R, Fazleabas A
Human reproduction (Oxford, England) 2012 Jun;27(6):1712-22
Human reproduction (Oxford, England) 2012 Jun;27(6):1712-22
Whole-body UVB irradiation during allogeneic hematopoietic cell transplantation is safe and decreases acute graft-versus-host disease.
Kreutz M, Karrer S, Hoffmann P, Gottfried E, Szeimies RM, Hahn J, Edinger M, Landthaler M, Andreesen R, Merad M, Holler E
The Journal of investigative dermatology 2012 Jan;132(1):179-87
The Journal of investigative dermatology 2012 Jan;132(1):179-87
Prolactin down-regulates CD4+CD25hiCD127low/- regulatory T cell function in humans.
Legorreta-Haquet MV, Chávez-Rueda K, Montoya-Díaz E, Arriaga-Pizano L, Silva-García R, Chávez-Sánchez L, Moreno-Lafont M, Zenteno-Galindo E, Blanco-Favela F
Journal of molecular endocrinology 2012 Feb;48(1):77-85
Journal of molecular endocrinology 2012 Feb;48(1):77-85
Phenotypic complexity of T regulatory subsets in patients with B-chronic lymphocytic leukemia.
Biancotto A, Dagur PK, Fuchs JC, Wiestner A, Bagwell CB, McCoy JP Jr
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2012 Feb;25(2):246-59
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2012 Feb;25(2):246-59
Absolute lymphocyte count is associated with survival in ovarian cancer independent of tumor-infiltrating lymphocytes.
Milne K, Alexander C, Webb JR, Sun W, Dillon K, Kalloger SE, Gilks CB, Clarke B, Köbel M, Nelson BH
Journal of translational medicine 2012 Feb 27;10:33
Journal of translational medicine 2012 Feb 27;10:33
OMIP-006: phenotypic subset analysis of human T regulatory cells via polychromatic flow cytometry.
Murdoch DM, Staats JS, Weinhold KJ
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2012 Apr;81(4):281-3
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2012 Apr;81(4):281-3
Naive T cells are dispensable for memory CD4+ T cell homeostasis in progressive simian immunodeficiency virus infection.
Okoye AA, Rohankhedkar M, Abana C, Pattenn A, Reyes M, Pexton C, Lum R, Sylwester A, Planer SL, Legasse A, Park BS, Piatak M Jr, Lifson JD, Axthelm MK, Picker LJ
The Journal of experimental medicine 2012 Apr 9;209(4):641-51
The Journal of experimental medicine 2012 Apr 9;209(4):641-51
Frequency of circulating regulatory T cells increases during chronic HIV infection and is largely controlled by highly active antiretroviral therapy.
Presicce P, Orsborn K, King E, Pratt J, Fichtenbaum CJ, Chougnet CA
PloS one 2011;6(12):e28118
PloS one 2011;6(12):e28118
Choice of resident costimulatory molecule can influence cell fate in human naïve CD4+ T cell differentiation.
Williams KM, Dotson AL, Otto AR, Kohlmeier JE, Benedict SH
Cellular immunology 2011;271(2):418-27
Cellular immunology 2011;271(2):418-27
A different immunologic profile characterizes patients with HER-2-overexpressing and HER-2-negative locally advanced breast cancer: implications for immune-based therapies.
Muraro E, Martorelli D, Turchet E, Miolo G, Scalone S, Comaro E, Talamini R, Mastorci K, Lombardi D, Perin T, Carbone A, Veronesi A, Crivellari D, Dolcetti R
Breast cancer research : BCR 2011;13(6):R117
Breast cancer research : BCR 2011;13(6):R117
Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses.
Dasgupta G, Chentoufi AA, You S, Falatoonzadeh P, Urbano LA, Akhtarmalik A, Nguyen K, Ablabutyan L, Nesburn AB, BenMohamed L
Investigative ophthalmology & visual science 2011 May 17;52(6):3321-33
Investigative ophthalmology & visual science 2011 May 17;52(6):3321-33
CD4+ T cells, including Th17 and cycling subsets, are intact in the gut mucosa of HIV-1-infected long-term nonprogressors.
Ciccone EJ, Greenwald JH, Lee PI, Biancotto A, Read SW, Yao MA, Hodge JN, Thompson WL, Kovacs SB, Chairez CL, Migueles SA, Kovacs JA, Margolis LB, Sereti I
Journal of virology 2011 Jun;85(12):5880-8
Journal of virology 2011 Jun;85(12):5880-8
Separation of human CD4+CD39+ T cells by magnetic beads reveals two phenotypically and functionally different subsets.
Schuler PJ, Harasymczuk M, Schilling B, Lang S, Whiteside TL
Journal of immunological methods 2011 Jun 30;369(1-2):59-68
Journal of immunological methods 2011 Jun 30;369(1-2):59-68
Anticardiac myosin immunity and chronic allograft vasculopathy in heart transplant recipients.
Kalache S, Dinavahi R, Pinney S, Mehrotra A, Cunningham MW, Heeger PS
Journal of immunology (Baltimore, Md. : 1950) 2011 Jul 15;187(2):1023-30
Journal of immunology (Baltimore, Md. : 1950) 2011 Jul 15;187(2):1023-30
Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies.
Jiang Y, Li W, Yu L, Liu J, Xin G, Yan H, Sun P, Zhang H, Xu D, Niu J
Cellular & molecular immunology 2011 Jan;8(1):75-82
Cellular & molecular immunology 2011 Jan;8(1):75-82
Hypoxia potentiates glioma-mediated immunosuppression.
Wei J, Wu A, Kong LY, Wang Y, Fuller G, Fokt I, Melillo G, Priebe W, Heimberger AB
PloS one 2011 Jan 20;6(1):e16195
PloS one 2011 Jan 20;6(1):e16195
miR-155, a Modulator of FOXO3a Protein Expression, Is Underexpressed and Cannot Be Upregulated by Stimulation of HOZOT, a Line of Multifunctional Treg.
Yamamoto M, Kondo E, Takeuchi M, Harashima A, Otani T, Tsuji-Takayama K, Yamasaki F, Kumon H, Kibata M, Nakamura S
PloS one 2011 Feb 3;6(2):e16841
PloS one 2011 Feb 3;6(2):e16841
Higher proportions of circulating FOXP3+ and CTLA-4+ regulatory T cells are associated with lower fractions of memory CD4+ T cells in infants.
Rabe H, Lundell AC, Andersson K, Adlerberth I, Wold AE, Rudin A
Journal of leukocyte biology 2011 Dec;90(6):1133-40
Journal of leukocyte biology 2011 Dec;90(6):1133-40
T cells expressing constitutively active Akt resist multiple tumor-associated inhibitory mechanisms.
Sun J, Dotti G, Huye LE, Foster AE, Savoldo B, Gramatges MM, Spencer DM, Rooney CM
Molecular therapy : the journal of the American Society of Gene Therapy 2010 Nov;18(11):2006-17
Molecular therapy : the journal of the American Society of Gene Therapy 2010 Nov;18(11):2006-17
Differential but direct abolishment of human regulatory T cell suppressive capacity by various TLR2 ligands.
Oberg HH, Ly TT, Ussat S, Meyer T, Kabelitz D, Wesch D
Journal of immunology (Baltimore, Md. : 1950) 2010 May 1;184(9):4733-40
Journal of immunology (Baltimore, Md. : 1950) 2010 May 1;184(9):4733-40
Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.
Oo YH, Weston CJ, Lalor PF, Curbishley SM, Withers DR, Reynolds GM, Shetty S, Harki J, Shaw JC, Eksteen B, Hubscher SG, Walker LS, Adams DH
Journal of immunology (Baltimore, Md. : 1950) 2010 Mar 15;184(6):2886-98
Journal of immunology (Baltimore, Md. : 1950) 2010 Mar 15;184(6):2886-98
PGE(2) contributes to TGF-beta induced T regulatory cell function in human non-small cell lung cancer.
Baratelli F, Lee JM, Hazra S, Lin Y, Walser TC, Schaue D, Pak PS, Elashoff D, Reckamp K, Zhang L, Fishbein MC, Sharma S, Dubinett SM
American journal of translational research 2010 Jun 30;2(4):356-67
American journal of translational research 2010 Jun 30;2(4):356-67
In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia.
Choi J, Ritchey J, Prior JL, Holt M, Shannon WD, Deych E, Piwnica-Worms DR, DiPersio JF
Blood 2010 Jul 8;116(1):129-39
Blood 2010 Jul 8;116(1):129-39
CD40 signalling induces IL-10-producing, tolerogenic dendritic cells.
Tuettenberg A, Fondel S, Steinbrink K, Enk AH, Jonuleit H
Experimental dermatology 2010 Jan;19(1):44-53
Experimental dermatology 2010 Jan;19(1):44-53
Effects of nilotinib on regulatory T cells: the dose matters.
Fei F, Yu Y, Schmitt A, Rojewski MT, Chen B, Greiner J, Götz M, Bunjes D, Schmitt M
Molecular cancer 2010 Jan 29;9:22
Molecular cancer 2010 Jan 29;9:22
Glioma-associated cancer-initiating cells induce immunosuppression.
Wei J, Barr J, Kong LY, Wang Y, Wu A, Sharma AK, Gumin J, Henry V, Colman H, Sawaya R, Lang FF, Heimberger AB
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Jan 15;16(2):461-73
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Jan 15;16(2):461-73
Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.
Amarnath S, Costanzo CM, Mariotti J, Ullman JL, Telford WG, Kapoor V, Riley JL, Levine BL, June CH, Fong T, Warner NL, Fowler DH
PLoS biology 2010 Feb 2;8(2):e1000302
PLoS biology 2010 Feb 2;8(2):e1000302
Photodepletion differentially affects CD4+ Tregs versus CD4+ effector T cells from patients with chronic graft-versus-host disease.
Bastien JP, Krosl G, Therien C, Rashkovan M, Scotto C, Cohen S, Allan DS, Hogge D, Egeler RM, Perreault C, Roy DC
Blood 2010 Dec 2;116(23):4859-69
Blood 2010 Dec 2;116(23):4859-69
Peroxisome proliferator-activated receptor α and γ agonists together with TGF-β convert human CD4+CD25- T cells into functional Foxp3+ regulatory T cells.
Lei J, Hasegawa H, Matsumoto T, Yasukawa M
Journal of immunology (Baltimore, Md. : 1950) 2010 Dec 15;185(12):7186-98
Journal of immunology (Baltimore, Md. : 1950) 2010 Dec 15;185(12):7186-98
Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis.
Smolders J, Peelen E, Thewissen M, Cohen Tervaert JW, Menheere P, Hupperts R, Damoiseaux J
PloS one 2010 Dec 13;5(12):e15235
PloS one 2010 Dec 13;5(12):e15235
FOXP3+ regulatory T cells and T helper 1, T helper 2, and T helper 17 cells in human early pregnancy decidua.
Mjösberg J, Berg G, Jenmalm MC, Ernerudh J
Biology of reproduction 2010 Apr;82(4):698-705
Biology of reproduction 2010 Apr;82(4):698-705
Fludarabine modulates immune response and extends in vivo survival of adoptively transferred CD8 T cells in patients with metastatic melanoma.
Wallen H, Thompson JA, Reilly JZ, Rodmyre RM, Cao J, Yee C
PloS one 2009;4(3):e4749
PloS one 2009;4(3):e4749
Regulatory T cell (Treg) subsets return in patients with refractory lupus following stem cell transplantation, and TGF-beta-producing CD8+ Treg cells are associated with immunological remission of lupus.
Zhang L, Bertucci AM, Ramsey-Goldman R, Burt RK, Datta SK
Journal of immunology (Baltimore, Md. : 1950) 2009 Nov 15;183(10):6346-58
Journal of immunology (Baltimore, Md. : 1950) 2009 Nov 15;183(10):6346-58
The role of the CD58 locus in multiple sclerosis.
De Jager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, Barcellos L, McCauley JL, Sawcer S, Goris A, Saarela J, Yelensky R, Price A, Leppa V, Patterson N, de Bakker PI, Tran D, Aubin C, Pobywajlo S, Rossin E, Hu X, Ashley CW, Choy E, Rioux JD, Pericak-Vance MA, Ivinson A, Booth DR, Stewart GJ, Palotie A, Peltonen L, Dubois B, Haines JL, Weiner HL, Compston A, Hauser SL, Daly MJ, Reich D, Oksenberg JR, Hafler DA
Proceedings of the National Academy of Sciences of the United States of America 2009 Mar 31;106(13):5264-9
Proceedings of the National Academy of Sciences of the United States of America 2009 Mar 31;106(13):5264-9
Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells.
Nagata S, Ise T, Pastan I
Journal of immunology (Baltimore, Md. : 1950) 2009 Jun 15;182(12):7518-26
Journal of immunology (Baltimore, Md. : 1950) 2009 Jun 15;182(12):7518-26
Determinants of in vitro expansion of different human virus-specific FoxP3+ regulatory CD8+ T cells in chronic hepatitis C virus infection.
Billerbeck E, Nakamoto N, Seigel B, Blum HE, Chang KM, Thimme R
The Journal of general virology 2009 Jul;90(Pt 7):1692-1701
The Journal of general virology 2009 Jul;90(Pt 7):1692-1701
Intratumoral immune cell infiltrates, FoxP3, and indoleamine 2,3-dioxygenase in patients with melanoma undergoing CTLA4 blockade.
Ribas A, Comin-Anduix B, Economou JS, Donahue TR, de la Rocha P, Morris LF, Jalil J, Dissette VB, Shintaku IP, Glaspy JA, Gomez-Navarro J, Cochran AJ
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Jan 1;15(1):390-9
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Jan 1;15(1):390-9
Unique phenotype of human tonsillar and in vitro-induced FOXP3+CD8+ T cells.
Siegmund K, Rückert B, Ouaked N, Bürgler S, Speiser A, Akdis CA, Schmidt-Weber CB
Journal of immunology (Baltimore, Md. : 1950) 2009 Feb 15;182(4):2124-30
Journal of immunology (Baltimore, Md. : 1950) 2009 Feb 15;182(4):2124-30
The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4+CD25+Foxp3+ regulatory T cells.
Law JP, Hirschkorn DF, Owen RE, Biswas HH, Norris PJ, Lanteri MC
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2009 Dec;75(12):1040-50
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2009 Dec;75(12):1040-50
CD13+CD4+CD25hi regulatory T cells exhibit higher suppressive function and increase with tumor stage in non-small cell lung cancer patients.
Ju S, Qiu H, Zhou X, Zhu B, Lv X, Huang X, Li J, Zhang Y, Liu L, Ge Y, Johnson DE, Ju S, Shu Y
Cell cycle (Georgetown, Tex.) 2009 Aug 15;8(16):2578-85
Cell cycle (Georgetown, Tex.) 2009 Aug 15;8(16):2578-85
Immune mediated autologous cytotoxicity against hematopoietic precursor cells in patients with myelodysplastic syndrome.
Chamuleau ME, Westers TM, van Dreunen L, Groenland J, Zevenbergen A, Eeltink CM, Ossenkoppele GJ, van de Loosdrecht AA
Haematologica 2009 Apr;94(4):496-506
Haematologica 2009 Apr;94(4):496-506
Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria.
Walther M, Jeffries D, Finney OC, Njie M, Ebonyi A, Deininger S, Lawrence E, Ngwa-Amambua A, Jayasooriya S, Cheeseman IH, Gomez-Escobar N, Okebe J, Conway DJ, Riley EM
PLoS pathogens 2009 Apr;5(4):e1000364
PLoS pathogens 2009 Apr;5(4):e1000364
Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation.
Hoffmann P, Boeld TJ, Eder R, Huehn J, Floess S, Wieczorek G, Olek S, Dietmaier W, Andreesen R, Edinger M
European journal of immunology 2009 Apr;39(4):1088-97
European journal of immunology 2009 Apr;39(4):1088-97
Naturally occurring regulatory T cells show reduced sensitivity toward oxidative stress-induced cell death.
Mougiakakos D, Johansson CC, Kiessling R
Blood 2009 Apr 9;113(15):3542-5
Blood 2009 Apr 9;113(15):3542-5
The effects of trastuzumab on the CD4+CD25+FoxP3+ and CD4+IL17A+ T-cell axis in patients with breast cancer.
Horlock C, Stott B, Dyson PJ, Morishita M, Coombes RC, Savage P, Stebbing J
British journal of cancer 2009 Apr 7;100(7):1061-7
British journal of cancer 2009 Apr 7;100(7):1061-7
Comparative study of regulatory T cell function of human CD25CD4 T cells from thymocytes, cord blood, and adult peripheral blood.
Fujimaki W, Takahashi N, Ohnuma K, Nagatsu M, Kurosawa H, Yoshida S, Dang NH, Uchiyama T, Morimoto C
Clinical & developmental immunology 2008;2008:305859
Clinical & developmental immunology 2008;2008:305859
Expression and function of PDCD1 at the human maternal-fetal interface.
Taglauer ES, Trikhacheva AS, Slusser JG, Petroff MG
Biology of reproduction 2008 Sep;79(3):562-9
Biology of reproduction 2008 Sep;79(3):562-9
Reciprocal CD4+ T-cell balance of effector CD62Llow CD4+ and CD62LhighCD25+ CD4+ regulatory T cells in small cell lung cancer reflects disease stage.
Koyama K, Kagamu H, Miura S, Hiura T, Miyabayashi T, Itoh R, Kuriyama H, Tanaka H, Tanaka J, Yoshizawa H, Nakata K, Gejyo F
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Nov 1;14(21):6770-9
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Nov 1;14(21):6770-9
Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin's lymphoma cells mediates Up-regulation of CCL20 and the migration of regulatory T cells.
Baumforth KR, Birgersdotter A, Reynolds GM, Wei W, Kapatai G, Flavell JR, Kalk E, Piper K, Lee S, Machado L, Hadley K, Sundblad A, Sjoberg J, Bjorkholm M, Porwit AA, Yap LF, Teo S, Grundy RG, Young LS, Ernberg I, Woodman CB, Murray PG
The American journal of pathology 2008 Jul;173(1):195-204
The American journal of pathology 2008 Jul;173(1):195-204
IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes.
Li Y, Yee C
Blood 2008 Jan 1;111(1):229-35
Blood 2008 Jan 1;111(1):229-35
Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype.
Tran DQ, Ramsey H, Shevach EM
Blood 2007 Oct 15;110(8):2983-90
Blood 2007 Oct 15;110(8):2983-90
Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells.
Crellin NK, Garcia RV, Levings MK
Blood 2007 Mar 1;109(5):2014-22
Blood 2007 Mar 1;109(5):2014-22
Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta.
Nadkarni S, Mauri C, Ehrenstein MR
The Journal of experimental medicine 2007 Jan 22;204(1):33-9
The Journal of experimental medicine 2007 Jan 22;204(1):33-9
IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin.
Clark RA, Kupper TS
Blood 2007 Jan 1;109(1):194-202
Blood 2007 Jan 1;109(1):194-202
GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells.
Mantel PY, Kuipers H, Boyman O, Rhyner C, Ouaked N, Rückert B, Karagiannidis C, Lambrecht BN, Hendriks RW, Crameri R, Akdis CA, Blaser K, Schmidt-Weber CB
PLoS biology 2007 Dec;5(12):e329
PLoS biology 2007 Dec;5(12):e329
Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25- T cells.
Amarnath S, Dong L, Li J, Wu Y, Chen W
Retrovirology 2007 Aug 9;4:57
Retrovirology 2007 Aug 9;4:57
FOXP3 regulates TLR10 expression in human T regulatory cells.
Bell MP, Svingen PA, Rahman MK, Xiong Y, Faubion WA Jr
Journal of immunology (Baltimore, Md. : 1950) 2007 Aug 1;179(3):1893-900
Journal of immunology (Baltimore, Md. : 1950) 2007 Aug 1;179(3):1893-900
IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo.
Zorn E, Nelson EA, Mohseni M, Porcheray F, Kim H, Litsa D, Bellucci R, Raderschall E, Canning C, Soiffer RJ, Frank DA, Ritz J
Blood 2006 Sep 1;108(5):1571-9
Blood 2006 Sep 1;108(5):1571-9
Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART.
Epple HJ, Loddenkemper C, Kunkel D, Tröger H, Maul J, Moos V, Berg E, Ullrich R, Schulzke JD, Stein H, Duchmann R, Zeitz M, Schneider T
Blood 2006 Nov 1;108(9):3072-8
Blood 2006 Nov 1;108(9):3072-8
Isolation of CD4+CD25+ regulatory T cells for clinical trials.
Hoffmann P, Boeld TJ, Eder R, Albrecht J, Doser K, Piseshka B, Dada A, Niemand C, Assenmacher M, Orsó E, Andreesen R, Holler E, Edinger M
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2006 Mar;12(3):267-74
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2006 Mar;12(3):267-74
IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients.
Ahmadzadeh M, Rosenberg SA
Blood 2006 Mar 15;107(6):2409-14
Blood 2006 Mar 15;107(6):2409-14
Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C.
Manigold T, Shin EC, Mizukoshi E, Mihalik K, Murthy KK, Rice CM, Piccirillo CA, Rehermann B
Blood 2006 Jun 1;107(11):4424-32
Blood 2006 Jun 1;107(11):4424-32
Transient accumulation of human mature thymocytes and regulatory T cells with CD28 superagonist in "human immune system" Rag2(-/-)gammac(-/-) mice.
Legrand N, Cupedo T, van Lent AU, Ebeli MJ, Weijer K, Hanke T, Spits H
Blood 2006 Jul 1;108(1):238-45
Blood 2006 Jul 1;108(1):238-45
Depletion of alloreactive T cells via CD69: implications on antiviral, antileukemic and immunoregulatory T lymphocytes.
Hartwig UF, Nonn M, Khan S, Meyer RG, Huber C, Herr W
Bone marrow transplantation 2006 Feb;37(3):297-305
Bone marrow transplantation 2006 Feb;37(3):297-305
Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion.
Hoffmann P, Eder R, Boeld TJ, Doser K, Piseshka B, Andreesen R, Edinger M
Blood 2006 Dec 15;108(13):4260-7
Blood 2006 Dec 15;108(13):4260-7
Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells.
Lim HW, Hillsamer P, Banham AH, Kim CH
Journal of immunology (Baltimore, Md. : 1950) 2005 Oct 1;175(7):4180-3
Journal of immunology (Baltimore, Md. : 1950) 2005 Oct 1;175(7):4180-3
Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells.
Lim HW, Hillsamer P, Banham AH, Kim CH
Journal of immunology (Baltimore, Md. : 1950) 2005 Oct 1;175(7):4180-3
Journal of immunology (Baltimore, Md. : 1950) 2005 Oct 1;175(7):4180-3
Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4+CD25+ T regulatory cells.
Crellin NK, Garcia RV, Hadisfar O, Allan SE, Steiner TS, Levings MK
Journal of immunology (Baltimore, Md. : 1950) 2005 Dec 15;175(12):8051-9
Journal of immunology (Baltimore, Md. : 1950) 2005 Dec 15;175(12):8051-9
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- Intracellular staining of normal human peripheral blood cells with Anti-Human CD4 FITC (Product # 11-0048-42) (left) or Anti-Human CD25 APC (Product # 17-0259-42) (right) and Anti-Human Foxp3 PE using the Foxp3/Transcription Factor Buffer Set (Product # 00-5523-00). Cells in the lymphocyte gate were used for analysis.
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- Intracellular staining of normal human peripheral blood cells with Anti-Human CD4 FITC (Product # 11-0048-42) (left) or Anti-Human CD25 APC (Product # 17-0259-42) (right) and Anti-Human Foxp3 PE using the Foxp3/Transcription Factor Buffer Set (Product # 00-5523-00). Cells in the lymphocyte gate were used for analysis.
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- Figure 1. Flow cytometric mapping of the CD4 + CD25 + Foxp3 + cells in peripheral blood withdrawn from the syphilitic patients with sero-resistance. Foxp3, forkhead box P3.
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- Figure 2 Phenotypic analysis of circulating regulatory T cells (Treg). A) Isolated PBMC were analyzed directly ex-vivo by flow cytometry. In the lymphogate, CD3 + CD4 + cells were assessed for the proportions of CD25 + FoxP3 + and CD25 + CD127 - Treg cells. Expression of CD45RA was analyzed to phenotype naive (CD45RA + ) and memory (CD45RA - ) Treg. B-D) The proportions of circulating CD25 + FoxP3 + (B) and CD25 + CD127 - (C)Treg, and of naive Treg (D) before and after vitamin D 3 supplementation (week 0 and 12). Significance was assessed with the Wilcoxon signed ranks comparison test.
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- Figure 3 Naive CD4 + T cells are converted to functional Tregs by tumor-infiltrating DCs and tumor conditioned medium (CM). (A-C) Naive CD4 + T cells from peripheral blood of patients with invasive breast carcinoma were co-cultured with or without autologous pDCs isolated from tumor (TI) or peripheral blood (PB) for 9 days in the presence or absence of 30% CM from autologous tumor slices or adjacent normal tissue slices. (A , B) Non-adherent cells from co-cultures were stained for CD3, CD4, CD25 and intracellular Foxp3, and analyzed by flow cytometry. Representative plots of gated CD3 + CD4 + cells (A) and quantification of percentage of Foxp3 + CD25 + cells among CD3 + CD4 + cells (B) are shown (mean +- SEM, n = 19; * P < 0.05, ** P < 0.01, *** P < 0.001 by Student's t -test). (C) Expression of Treg-associated genes, assessed by qRT-PCR normalized to GAPDH , in sorted CD4 + T cells, relative to expression in cultures without DCs or CM (mean +- SEM, n = 19; * P < 0.05, ** P < 0.01, *** P < 0.001 compared with naive CD4 + T cells cultured alone by Student's t -test). (D-G) Effect of naive CD4 + T cell-derived Tregs, obtained by co-culture with TI pDCs and tumor CM as above, on function of autologous tumor-specific CD8 + T cells. Tumor-specific CD8 + T cells were generated for each subject by stimulating autologous PB CD8 + T cells with autologous tumor lysate-pulsed autologous DCs. Tregs were recovered from co-cultures by magnetic sorting. (D) CFSE-labeled CD8 + T ce
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- Figure 6 In vivo knockdown of PITPNM3 in CD4 + T cells reverses immunosuppression and inhibits tumor progression in humanized mice. (A) Humanized mice bearing palpable MDA-MB-231 orthotopic xenografts were intraperitoneally injected daily for 14 days with PBS, 1 nmol CD4-aptamer-control siRNA (AsiC-con) or CD4-aptamer-siRNA targeting PITPNM3 (sequence in A , AsiC-PI) to assess the role of PITPNM3 in TI Tregs, and other T cells and tumor control. Experimental schematic is provided in Supplementary information, Figure S9A . (B) Representative immunoblots showing selective knockdown of PITPNM3 protein in PB CD4 + T cells, but not tumor xenografts ( n = 3). (C) PITPNM3 knockdown did not affect the distribution of human CD45 + hematopoietic cells, CD4 + and CD8 + T cells, and CD14 + monocytes in the peripheral blood of humanized mice. Representative flow plots are shown ( n = 3). (D , E) Effect of PITPNM3 knockdown on TI naive CD4 + , Tregs and CD8 + T cell numbers, and apoptosis by TUNEL assay in xenografts. D shows representative immunofluorescence microscopy images. Top row indicates CD4 + naive T cells by arrows; the second row indicates CD4 + CD45RO + Foxp3 - CD4 + memory T cells (yellow arrows) and Foxp3 + Tregs (white arrows). Scale bar, 50 mum. E shows number of cells of each subtype/high power field in eight mice ( ** P < 0.01, *** P < 0.001 compared to PBS group by Student's t -test). (F) Flow cytometry analysis of gated human CD3 + CD4 + cells isolated from xenogra
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