320101

antibody from BioLegend

Targeting: FOXP3 AIID, DIETER, IPEX, JM2, PIDX, SCURFIN, XPID

Immunohistochemistry

Flow cytometry

Antibody data

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Validation data

Product number: 320101 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#320101, RRID:AB_430880
Product name: Purified anti-human FOXP3
Antibody type: Monoclonal
Antigen: full-length FOXP3 protein
Description: FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. The 206D antibody recognizes human FOXP3 epitope in the region of amino acids 105-235.
Reactivity: Human, Simian
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Vial size: 25 µg
Concentration: 0.5 mg/ml
Storage: The antibody solution should be stored undiluted at 4°C.