22228-1-AP

antibody from Proteintech Group

Targeting: FOXP3 AIID, DIETER, IPEX, JM2, PIDX, SCURFIN, XPID

Provider product page for 22228-1-AP

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ELISA

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [64]
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Validations
Western blot [1]
Immunoprecipitation [1]

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Product number: 22228-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#22228-1-AP, RRID:AB_11182376
Product name: FOXP3 antibody
Antibody type: Polyclonal
Description: FOXP3 antibody (Cat. #22228-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

FOXP3 protein structure - 22228-1-AP shown in red.

Submitted references Expression landscape of cancer-FOXP3 and its prognostic value in pancreatic adenocarcinoma.

Gong R, Wang J, Xing Y, Wang J, Chen X, Lei K, Yu Q, Zhao C, Li S, Zhang Y, Wang H, Ren H
Cancer letters 2024 May 28;590:216838

Fatostatin promotes anti-tumor immunity by reducing SREBP2 mediated cholesterol metabolism in tumor-infiltrating T lymphocytes.

Zhu L, Shi Y, Feng Z, Yuan D, Guo S, Wang Y, Shen H, Li Y, Yan F, Wang Y
European journal of pharmacology 2024 May 15;971:176519

Efficacy and Mechanism of the Action of Live and Heat-Killed Bacillus coagulans BC198 as Potential Probiotic in Ameliorating Dextran Sulfate Sodium-Induced Colitis in Mice.

Koh YC, Chang YC, Lin WS, Leung SY, Chen WJ, Wu SH, Wei YS, Gung CL, Chou YC, Pan MH
ACS omega 2024 Mar 5;9(9):10253-10266

ROS-responsive drug-releasing injectable microgels for ameliorating myocardial infarction.

Wang S, Yao Y, Song L, Zhai Z, Li S, Wang Z, Shen L, Zhu Y, Liu W, Gao C
Biomaterials 2024 Jun;307:122534

FOXP3-regulated lncRNA NONHSAT136151 promotes colorectal cancer progression by disrupting QKI interaction with target mRNAs.

Huang H, Liang X, Wu W, Yuan T, Chen Z, Wang L, Wu Z, Zhang T, Yang K, Wen K
Journal of cellular and molecular medicine 2024 Jan;28(2):e18068

β-Indole-3-acetic acid attenuated collagen-induced arthritis through reducing the ubiquitination of Foxp3 via the AhR-TAZ-Tip60 pathway.

Su X, Wang X, Zhang X, Sun Y, Jia Y
Immunologic research 2024 Aug;72(4):741-753

A positive FOXP3/lncRNA SNHG1 feedback axis ameliorates cardiomyocytes hypertrophy by negatively regulating Parkin-mediated mitophagy.

Zhang J, Luo X, Yang X, Wang B, Zheng L, Yan S
International immunopharmacology 2024 Aug 20;137:112526

Glycyrrhetinic acid inhibits non-small cell lung cancer via promotion of Prdx6- and caspase-3-mediated mitochondrial apoptosis.

Guo Q, Zhao M, Wang Q, Lu T, Luo P, Chen L, Xia F, Pang H, Shen S, Cheng G, Dai C, Meng Y, Zhong T, Qiu C, Wang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Apr;173:116304

Diaphorobacter nitroreducens synergize with oxaliplatin to reduce tumor burden in mice with lung adenocarcinoma.

Ni Y, Li R, Shen X, Yi D, Ren Y, Wang F, Geng Y, You Q
mSystems 2024 Apr 16;9(4):e0132323

Epigenetically regulated lncRNAs dissect the intratumoural heterogeneity and facilitate immune evasion of glioblastomas.

Xu D, Cao M, Wang B, Bi X, Zhang H, Wu D, Zhang C, Xu J, Xu Z, Zheng D, Chen L, Li P, Wang H, Liu Y, Jiang H, Li K
Theranostics 2023;13(5):1490-1505

Ileocecal involvement in intestinal Behçet's disease and Crohn's disease: comparison of clinicopathological and immunophenotypic features.

Wu YC, Fu YJ, Xia HJ, Zhu J, Huang Y, Jiang ZN
Journal of digestive diseases 2023 Nov;24(11):594-602

PCSK9 inhibition ameliorates experimental autoimmune myocarditis by reducing Th17 cell differentiation through LDLR/STAT-3/ROR-γt pathway.

Yu M, Tang W, Liang W, Xie B, Gao R, Ding P, Gu X, Wang M, Wen S, Sun P
International immunopharmacology 2023 Nov;124(Pt B):110962

Dietary alpha-ketoglutarate enhances intestinal immunity by Th17/Treg immune response in piglets after lipopolysaccharide challenge.

Liu GM, Lu JJ, Sun WX, Jia G, Zhao H, Chen XL, Tian G, Cai JY, Zhang RN, Wang J
Journal of animal science 2023 Jan 3;101

Effects of lactate on metabolism and differentiation of CD4(+)T cells.

Zhang YT, Xing ML, Fang HH, Li WD, Wu L, Chen ZP
Molecular immunology 2023 Feb;154:96-107

Identification of a novel immune checkpoint molecule V-set immunoglobulin domain-containing 4 that leads to impaired immunity infiltration in pancreatic ductal adenocarcinoma.

Jiang Y, Han L, Yang J, Yang M, Zhang J, Xue M, Zhu Y, Xiong C, Shi M, Zhao S, Shen B, Xu Z, Jiang L, Chen H
Cancer immunology, immunotherapy : CII 2023 Aug;72(8):2701-2716

The super-enhancer-driven lncRNA LINC00880 acts as a scaffold between CDK1 and PRDX1 to sustain the malignance of lung adenocarcinoma.

Feng Y, Zhang T, Zhang Z, Liang Y, Wang H, Chen Y, Yu X, Song X, Mao Q, Xia W, Chen B, Xu L, Dong G, Jiang F
Cell death & disease 2023 Aug 24;14(8):551

Regulatory T cells showed characteristics of T helper-17(Th17) cells in mice periodontitis model.

Kou Y, Jiang Y, Liu S, Yang P, Lu Y, Liu H, Li M
Oral diseases 2023 Apr;29(3):1149-1162

GPC1 Is Associated with Poor Prognosis and Treg Infiltration in Colon Adenocarcinoma.

Liu Y, Ren H, Yang MQ, Li JY
Computational and mathematical methods in medicine 2022;2022:8209700

Bifidobacterium infantis Promotes Foxp3 Expression in Colon Cells via PD-L1-Mediated Inhibition of the PI3K-Akt-mTOR Signaling Pathway.

Zhou L, Xie Y, Li Y
Frontiers in immunology 2022;13:871705

Identification and experimental validation of a tumor-infiltrating lymphocytes-related long noncoding RNA signature for prognosis of clear cell renal cell carcinoma.

Deng Y, Guo K, Tang Z, Feng Y, Cai S, Ye J, Xi Y, Li J, Liu R, Cai C, Tan Z, Zhang Y, Han Z, Zeng G, Zhong W
Frontiers in immunology 2022;13:1046790

The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells by encoding a novel protein NTRK2-243aa.

Zhao Y, Song J, Dong W, Liu X, Yang C, Wang D, Xue Y, Ruan X, Liu L, Wang P, Zhang M, Liu Y
Cell death & disease 2022 Sep 5;13(9):767

Oral Intervention of Narirutin Ameliorates the Allergic Response of Ovalbumin Allergy.

Shi X, Zhao L, Niu L, Yan Y, Chen Q, Jin Y, Li X
Journal of agricultural and food chemistry 2022 Oct 19;70(41):13313-13326

LncRNA-targeting bio-scaffold mediates triple immune effects for postoperative colorectal cancer immunotherapy.

Liu F, Dai Z, Cheng Q, Xu L, Huang L, Liu Z, Li X, Wang N, Wang G, Wang L, Wang Z
Biomaterials 2022 May;284:121485

Folic acid intervention changes liver Foxp3 methylation and ameliorates the damage caused by Th17/Treg imbalance after long-term alcohol exposure.

Zhao H, Guo P, Zuo Y, Wang Y, Zhao H, Lan T, Xue M, Zhang H, Liang H
Food & function 2022 May 10;13(9):5262-5274

Polymeric indoximod based prodrug nanoparticles with doxorubicin entrapment for inducing immunogenic cell death and improving the immunotherapy of breast cancer.

Zang X, Song J, Yi X, Piyu J
Journal of materials chemistry. B 2022 Mar 23;10(12):2019-2027

Multi-material basis and multi-mechanisms of the Dahuang Zhechong pill for regulating Treg/Th1 balance in hepatocellular carcinoma.

Wu L, Yang FR, Xing ML, Lu SF, Chen HL, Yang QW, Zhang YT, Lu Y, Huang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154055

Bifidobacterium infantis regulates the programmed cell death 1 pathway and immune response in mice with inflammatory bowel disease.

Zhou LY, Xie Y, Li Y
World journal of gastroenterology 2022 Jul 14;28(26):3164-3176

Qing-Chang-Hua-Shi granule ameliorates DSS-induced colitis by activating NLRP6 signaling and regulating Th17/Treg balance.

Cheng C, Hu J, Li Y, Ji Y, Lian Z, Au R, Xu F, Li W, Shen H, Zhu L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154452

IGF2BP2-induced circRUNX1 facilitates the growth and metastasis of esophageal squamous cell carcinoma through miR-449b-5p/FOXP3 axis.

Wang C, Zhou M, Zhu P, Ju C, Sheng J, Du D, Wan J, Yin H, Xing Y, Li H, He J, He F
Journal of experimental & clinical cancer research : CR 2022 Dec 15;41(1):347

Panax notoginseng saponins prevent colitis-associated colorectal cancer via inhibition IDO1 mediated immune regulation.

Li XM, Yuan DY, Liu YH, Zhu L, Qin HK, Yang YB, Li Y, Yan F, Wang YJ
Chinese journal of natural medicines 2022 Apr;20(4):258-269

Huganbuzure Granule Attenuates Concanavalin-A-Induced Immune Liver Injury in Mice via Regulating the Balance of Th1/Th2/Th17/Treg Cells and Inhibiting Apoptosis.

Wang M, Yin H, Xia Y, Tu Y, Zou X, Song W, Luo L, Wu H, Yang Y, Zan J, Liu Y, Dan H, Yin Q, You P
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5578021

FOXP3 Inhibits the Metastasis of Breast Cancer by Downregulating the Expression of MTA1.

Liu C, Han J, Li X, Huang T, Gao Y, Wang B, Zhang K, Wang S, Zhang W, Li W, Hao Q, Li M, Zhang Y, Zhang C
Frontiers in oncology 2021;11:656190

Self-assembled FeS-based cascade bioreactor with enhanced tumor penetration and synergistic treatments to trigger robust cancer immunotherapy.

Ren H, Yong J, Yang Q, Yang Z, Liu Z, Xu Y, Wang H, Jiang X, Miao W, Li X
Acta pharmaceutica Sinica. B 2021 Oct;11(10):3244-3261

The immunosuppressive role of Edn3 overexpression in the melanoma microenvironment.

Freitas JT, Lopez J, Llorian C, Boroni M, Kos L
Pigment cell & melanoma research 2021 Nov;34(6):1084-1093

Clinical and Molecular Characterizations of Papillary Thyroid Cancer in Children and Young Adults: A Multicenter Retrospective Study.

Guo K, Qian K, Shi Y, Sun T, Chen L, Mei D, Dong K, Gu S, Liu J, Lv Z, Wang Z
Thyroid : official journal of the American Thyroid Association 2021 Nov;31(11):1693-1706

Mifepristone regulates Tregs function mediated by dendritic cells through suppressing the expression of TGF-β.

Li Y, Cao L, Qian Z, Guo Q, Niu X, Huang L
Immunopharmacology and immunotoxicology 2021 Feb;43(1):85-93

Aiduqing formula inhibits breast cancer metastasis by suppressing TAM/CXCL1-induced Treg differentiation and infiltration.

Li J, Wang S, Wang N, Zheng Y, Yang B, Wang X, Zhang J, Pan B, Wang Z
Cell communication and signaling : CCS 2021 Aug 30;19(1):89

A PD-1 peptide antagonist exhibits potent anti-tumor and immune regulatory activity.

Tao H, Cheng L, Liu L, Wang H, Jiang Z, Qiang X, Xing L, Xu Y, Cai X, Yao J, Wang M, Qiu Z
Cancer letters 2020 Nov 28;493:91-101

Glycolytic and lipid oxidative metabolic programs are essential for freshly-isolated regulatory T cells in mice with sepsis.

Zhu X, Ji W, Guo S, Zhu D, Yang Y, Liu X
RSC advances 2020 May 27;10(35):21000-21008

Regulatory T cell is critical for interleukin-33-mediated neuroprotection against stroke.

Liu X, Hu R, Pei L, Si P, Wang C, Tian X, Wang X, Liu H, Wang B, Xia Z, Xu Y, Song B
Experimental neurology 2020 Jun;328:113233

MiRNA-516a promotes bladder cancer metastasis by inhibiting MMP9 protein degradation via the AKT/FOXO3A/SMURF1 axis.

Chang Y, Jin H, Li H, Ma J, Zheng Z, Sun B, Lyu Y, Lin M, Zhao H, Shen L, Zhang R, Wu S, Lin W, Lu Y, Xie Q, Zhang G, Huang X, Huang H
Clinical and translational medicine 2020 Dec;10(8):e263

The Chinese medicinal herb decoction QRZSLXF enhances anti-inflammatory effect in TNBS-induced colitis via balancing Th17/Tregs differentiation.

Zhang M, Fan H, Tan S, Tang Q, Liu X, Zuo D, Liao Y, Nan Z, Tan C
Journal of ethnopharmacology 2020 Apr 6;251:112549

SFRP4 is a prognostic marker and correlated with Treg cell infiltration in pancreatic ductal adenocarcinoma.

Yang MW, Tao LY, Yang JY, Jiang YS, Fu XL, Liu W, Huo YM, Li J, Zhang JF, Hua R, Qin XR, Sun YW, Liu DJ
American journal of cancer research 2019;9(2):363-377

Changes in Tumor-Infiltrating Lymphocytes and Vascular Normalization in Breast Cancer Patients After Neoadjuvant Chemotherapy and Their Correlations With DFS.

Wang Q, Xiang Q, Yu L, Hu T, Chen Y, Wang J, Nie X, Cheng J
Frontiers in oncology 2019;9:1545

DKK2 Impairs Tumor Immunity Infiltration and Correlates with Poor Prognosis in Pancreatic Ductal Adenocarcinoma.

Yang J, Jiang Y, He R, Liu W, Yang M, Tao L, Fu X, Shen Y, Li J, Liu D, Huo Y, Zhang J, Hua R, Zhang Z, Sun Y
Journal of immunology research 2019;2019:8656282

The Hypermethylation of Foxp3 Promoter Impairs the Function of Treg Cells in EAP.

Chen J, Zhan C, Zhang L, Zhang L, Liu Y, Zhang Y, Du H, Liang C, Chen X
Inflammation 2019 Oct;42(5):1705-1718

Bifidobacterium infantis Induces Protective Colonic PD-L1 and Foxp3 Regulatory T Cells in an Acute Murine Experimental Model of Inflammatory Bowel Disease.

Zhou L, Liu D, Xie Y, Yao X, Li Y
Gut and liver 2019 Mar 15;13(4):430-439

Glycyrrhizic acid ammonium salt alleviates Concanavalin A-induced immunological liver injury in mice through the regulation of the balance of immune cells and the inhibition of hepatocyte apoptosis.

Tian X, Liu Y, Liu X, Gao S, Sun X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109481

NF-κB-driven miR-34a impairs Treg/Th17 balance via targeting Foxp3.

Xie M, Wang J, Gong W, Xu H, Pan X, Chen Y, Ru S, Wang H, Chen X, Zhao Y, Li J, Yin Q, Xia S, Zhou X, Liu X, Shao Q
Journal of autoimmunity 2019 Aug;102:96-113

Changes among TGF-β1(+) Breg cells and helper T cell subsets in a murine model of allergic rhinitis with prolonged OVA challenge.

Wang M, Gu Z, Yang J, Zhao H, Cao Z
International immunopharmacology 2019 Apr;69:347-357

Clinical significance of programmed death 1/programmed death ligand 1 pathway in gastric neuroendocrine carcinomas.

Yang MW, Fu XL, Jiang YS, Chen XJ, Tao LY, Yang JY, Huo YM, Liu W, Zhang JF, Liu PF, Liu Q, Hua R, Zhang ZG, Sun YW, Liu DJ
World journal of gastroenterology 2019 Apr 14;25(14):1684-1696

PPAR-γ Agonist Alleviates Liver and Spleen Pathology via Inducing Treg Cells during Schistosoma japonicum Infection.

Zhu Y, Ni Y, Liu R, Hou M, Yang B, Song J, Sun H, Xu Z, Ji M
Journal of immunology research 2018;2018:6398078

Deletion of the C6orf120 gene with unknown function ameliorates autoimmune hepatitis induced by concanavalin A.

Zhang MK, Ma HM, Zhang J, Song XC, Ye XH, Li YF, Zhang YF, He LL, Wei HS, Li X
Cellular immunology 2018 Sep;331:9-15

Kuijieling regulates the differentiation of Treg and Th17 cells to ameliorate experimental colitis in rats.

Long Y, Li S, Qin J, Xie L, Gan L, Jie F, Wu Y, Li Y, Du Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Sep;105:781-788

Erythropoietin Treatment Ameliorates Lupus Nephritis of MRL/lpr Mice.

Zhang Z, Liu D, Zhang X, Wang X
Inflammation 2018 Oct;41(5):1888-1899

Sonodynamic therapy-assisted immunotherapy: A novel modality for cancer treatment.

Zhang Q, Bao C, Cai X, Jin L, Sun L, Lang Y, Li L
Cancer science 2018 May;109(5):1330-1345

Epigenetic Regulation of CXCL12 Plays a Critical Role in Mediating Tumor Progression and the Immune Response In Osteosarcoma.

Li B, Wang Z, Wu H, Xue M, Lin P, Wang S, Lin N, Huang X, Pan W, Liu M, Yan X, Qu H, Sun L, Li H, Wu Y, Teng W, Wang Z, Zhou X, Chen H, Poznansky MC, Ye Z
Cancer research 2018 Jul 15;78(14):3938-3953

Faecalibacterium prausnitzii Produces Butyrate to Maintain Th17/Treg Balance and to Ameliorate Colorectal Colitis by Inhibiting Histone Deacetylase 1.

Zhou L, Zhang M, Wang Y, Dorfman RG, Liu H, Yu T, Chen X, Tang D, Xu L, Yin Y, Pan Y, Zhou Q, Zhou Y, Yu C
Inflammatory bowel diseases 2018 Aug 16;24(9):1926-1940

Regulatory effect of baicalin on the imbalance of Th17/Treg responses in mice with allergic asthma.

Xu L, Li J, Zhang Y, Zhao P, Zhang X
Journal of ethnopharmacology 2017 Aug 17;208:199-206

Upregulated Expression of microRNA-16 Correlates with Th17/Treg Cell Imbalance in Patients with Rheumatoid Arthritis.

Wu YH, Liu W, Xue B, Zhang L, Liu XY, Liu B, Wang Y, Cai Y, Duan R
DNA and cell biology 2016 Dec;35(12):853-860

Effect of IL-17 in the development of colon cancer in mice.

Yang L, Liu H, Zhang L, Hu J, Chen H, Wang L, Yin X, Li Q, Qi Y
Oncology letters 2016 Dec;12(6):4929-4936

The Dynamics of Treg/Th17 and the Imbalance of Treg/Th17 in Clonorchis sinensis-Infected Mice.

Yan C, Zhang BB, Hua H, Li B, Zhang B, Yu Q, Li XY, Liu Y, Pan W, Liu XY, Tang RX, Zheng KY
PloS one 2015;10(11):e0143217

rFliC prolongs allograft survival in association with the activation of recipient Tregs in a TLR5-dependent manner.

Hao J, Zhang C, Liang T, Song J, Hou G
Cellular & molecular immunology 2014 Mar;11(2):206-14

Up-regulation of microRNA-210 induces immune dysfunction via targeting FOXP3 in CD4(+) T cells of psoriasis vulgaris.

Zhao M, Wang LT, Liang GP, Zhang P, Deng XJ, Tang Q, Zhai HY, Chang CC, Su YW, Lu QJ
Clinical immunology (Orlando, Fla.) 2014 Jan;150(1):22-30

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 22228-1-AP(FOXP3 antibody) at dilution of 1:2000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The FOXP3 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human FOXP3. This antibody recognizes human,mouse,rat antigen. The FOXP3 antibody has been validated for the following applications: ELISA, WB, IP analysis.
Appendix: 22228-1-AP.pdf

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