HPA040913

antibody from Atlas Antibodies

Targeting: MGME1 bA504H3.4, C20orf72, DDK1

Western blot (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

HPA040913

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA040913, RRID:AB_10962835

Product name

Anti-MGME1

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human MGME1, Gene description: mitochondrial genome maintenance exonuclease 1, Alternative Gene Names: bA504H3.4, C20orf72, DDK1, Validated applications: ICC, IHC, WB, Uniprot ID: Q9BQP7, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.2 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

Linear DNA-driven recombination in mammalian mitochondria

Fragkoulis G, Hangas A, Fekete Z, Michell C, Moraes C, Willcox S, Griffith J, Goffart S, Pohjoismäki J
Nucleic Acids Research 2024;52(6):3088-3105

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Top3α is the replicative topoisomerase in mitochondrial DNA replication

Hangas A, Kekäläinen N, Potter A, Michell C, Aho K, Rutanen C, Spelbrink J, Pohjoismäki J, Goffart S
Nucleic Acids Research 2022;50(15):8733-8748

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Linear mitochondrial DNA is rapidly degraded by components of the replication machinery

Peeva V, Blei D, Trombly G, Corsi S, Szukszto M, Rebelo-Guiomar P, Gammage P, Kudin A, Becker C, Altmüller J, Minczuk M, Zsurka G, Kunz W
Nature Communications 2018;9(1)

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Selective mitochondrial DNA degradation following double-strand breaks

Sola M, Moretton A, Morel F, Macao B, Lachaume P, Ishak L, Lefebvre M, Garreau-Balandier I, Vernet P, Falkenberg M, Farge G
PLOS ONE 2017;12(4):e0176795

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Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonuclease

Nicholls T, Zsurka G, Peeva V, Schöler S, Szczesny R, Cysewski D, Reyes A, Kornblum C, Sciacco M, Moggio M, Dziembowski A, Kunz W, Minczuk M
Human Molecular Genetics 2014;23(23):6147-6162

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Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease

Kornblum C, Nicholls T, Haack T, Schöler S, Peeva V, Danhauser K, Hallmann K, Zsurka G, Rorbach J, Iuso A, Wieland T, Sciacco M, Ronchi D, Comi G, Moggio M, Quinzii C, DiMauro S, Calvo S, Mootha V, Klopstock T, Strom T, Meitinger T, Minczuk M, Kunz W, Prokisch H
Nature Genetics 2013;45(2):214-219

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Identification of a novel human mitochondrial endo-/exonuclease Ddk1/c20orf72 necessary for maintenance of proper 7S DNA levels

Szczesny R, Hejnowicz M, Steczkiewicz K, Muszewska A, Borowski L, Ginalski K, Dziembowski A
Nucleic Acids Research 2013;41(5):3144-3161