27779-1-AP

antibody from Proteintech Group

Targeting: YTHDC2 DKFZp564A186, FLJ10053, FLJ2194

Provider product page for 27779-1-AP

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Immunocytochemistry

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Antibody Data
Antigen structure
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Product number: 27779-1-AP - Provider product page
Provider: Proteintech Group
Product name: YTHDC2 antibody
Antibody type: Polyclonal
Description: KD/KO validated YTHDC2 antibody (Cat. #27779-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human, mouse and has been validated for the following applications: IF, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

YTHDC2 protein structure - 27779-1-AP shown in red.

Submitted references YTHDC1 Orchestrates Telomerase Assembly via Scaffold-Mediated TERT-TERC Interaction.

Cheng X, Wang S, Yu Y, Xu J, Wang Q, Wei Y, Jin Z, Qi X, Jian D, Shi Y, Li Z, Ma Z, Wang W, Xia T, Xing J, Gu X, Tang H
Aging cell 2026 Jan;25(1):e70332

Ythdc1-p300-Klf5 Complex-Mediated Golgi Dysfunction Promotes Aortic Aneurysm.

Wang WL, Song ZX, Bu SM, Liu YM, Li Q, Zhang WX, Sun XR, Zhang X, Xiao YX, Bo D, Miao XB, Liu C, Zhang XH, Zheng L, Zhao HY, Zhang BL, Jia W, Chi K, Liu Y, Zhao YB, Zheng B, Ma D, Wen JK
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(4):e12116

METTL3-mediated m6A modification of FDX1 confers resistance to cuproptosis and promotes hepatocellular carcinoma progression.

Jiang Q, Peng C, Mao W, Yu Z, Feng Y, Li Y, Zhu J, Zhao J, Liao D, Sun T
Communications biology 2026 Jan 8;9(1):222

m6A RNA methylation modulates antiviral response in celiac disease.

Sebastian-delaCruz M, Olazagoitia-Garmendia A, Pascual-Gonzalez I, Mendoza LM, Legarda M, Tutau C, Bujanda L, Ghosh S, Santin I, Postler TS, Bilbao JR, Castellanos-Rubio A
Genes and immunity 2026 Feb;27(1):130-139

METTL14 alleviates heat stress in Hu sheep involves enhancing fatty acid oxidation while reducing lipid deposition.

Chen B, Yuan C, Guo T, Sun L, Liu J, Lu Z
Frontiers in veterinary science 2025;12:1732947

Changes of N6-methyladenosine and ferroptosis in cadmium-induced reproductive toxicity of male mice fed a high fat and high sugar diet.

Liu D, Zhao Y, Dai J, Li R, Yuan J, Shen K, He Z, Gu S
Toxicology 2025 Sep;516:154172

Elevated CircYthdc2 expression is correlated with aggressive features and poor progression-free survival in hepatocellular carcinoma.

Gong Y, Li X, Wang M
BMC gastroenterology 2025 Sep 26;25(1):658

METTL3-Driven m6A Epigenetic Remodeling of lncRNA-AU020206 Stabilizes SLC7A11 via YTHDC2 Attenuates Apoptosis and Ferroptosis in Cerebral Ischemia/Reperfusion Injury.

Zhang H, Guan Y, Li M, Wu Y, Sun X
Biomolecules 2025 Sep 24;15(10)

RBM15-mediated m6A methylation of Entpd1/CD39 regulates extracellular ATP hydrolysis and alleviates myocardial ischemia-reperfusion injury.

Yan Z, Cao H, Zhang X, Wang Y, Chang Q
International immunopharmacology 2025 Sep 23;162:115141

Changes of N(6)-methyladenosine modification and unfolded protein response in renal cell injury induced by cadmium.

Wang N, Dai J, Li R, Li W, Liu D, Liu X, Mei Z, Lu H, He Z, Gu S
Ecotoxicology and environmental safety 2025 Oct 15;305:119228

FTO aggravates podocyte injury and diabetic nephropathy progression via m6A-dependent stabilization of ACC1 mRNA and promoting fatty acid metabolism.

Chang K, Hong F, Liu H, Fang Y, Wang H, Song N, Ning Y, Lu Z, Jin S, Dai Y, Ding X
Biochemical pharmacology 2025 May;235:116819

YTHDF1 shapes immune-mediated hepatitis via regulating inflammatory cell recruitment and response.

Li H, Yu K, Zhang X, Li J, Hu H, Deng X, Zeng S, Dong X, Zhao J, Zhang Y
Genes & diseases 2025 May;12(3):101327

Targeting Zfp36 to combat cardiac hypertrophy: Insights into ferroptosis pathways.

Zhang M, Guan X, Dong Z, Yang C, Xiong C, Cheng W, Shang A, Liu Y, Guo X, Zhang B, Zhang B, Jin S, Qi W, Alexandrovna BT, Jiang Y, Du Z, Xu C
Clinical and translational medicine 2025 Mar;15(3):e70247

METTL14-mediated m6A modification of ETV4 inhibits tumor development in colorectal cancer.

Liao X, Hu T
Mutation research 2025 Jul-Dec;831:111910

N(6)-Methyladenosine Regulates Cilia Elongation in Cancer Cells by Modulating HDAC6 Expression.

Rui Y, Zhang H, Yu K, Qiao S, Gao C, Wang X, Yang W, Asadikaram G, Li Z, Zhang K, Peng J, Li J, He J, Wang H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(2):e2408488

RNA m(6)A involves in regulation of oxidative stress and apoptosis may via NF-kB pathway in cadmium-induced lung cells.

Zhang N, Yang J, Zhao Y, Li W, Zhao B, Li R, He Z, Gu S
Cell death discovery 2025 Jan 10;11(1):4

USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation.

Shao N, Xi L, Lv Y, Idris M, Zhang L, Cao Y, Xiang J, Xu X, Ong BX, Zhang Q, Peng X, Yue X, Xu F, Liu C
Nature communications 2025 Feb 3;16(1):1313

TNF-α-driven m6A modification disrupts the immunoregulatory function of MSCs by regulating HDAC5-dependent super-enhancers.

Zhang W, Lin J, Zhou Y, Wu C, Li Q, Chen J, Zeng Y, Xiao Z, Shen H, Wu Y, Su Z, Yu W, Xie Z
Cell death & disease 2025 Dec 23;16(1):902

ZC3H13 mediates N6-methyladenosine modification of SNTB1 to promote epithelial-mesenchymal transition in gastric cancer.

Xie X, Zhao Y, Liu J, Li H, Zhu X, Liu Y, Sang Y, Xu K, Du F, Ren H, Cui X, Cai B, Chen H, Wu N, Hou G, Jing C, Chong W, Li L, Shang L
Cell death & disease 2025 Aug 7;16(1):596

Nuclear accumulation of YTHDF1 regulates mRNA splicing in the DNA damage response.

Hou J, Gao Y, Han B, Yan S, Wei S, Gao X
Science advances 2025 Apr 18;11(16):eado7660

m6A reader IGF2BP1 facilitates macrophage glycolytic metabolism and fibrotic phenotype by stabilizing THBS1 mRNA to promote pulmonary fibrosis.

Hu Y, Yang L, Huang L, Zeng C, Ren S
Cellular and molecular life sciences : CMLS 2025 Apr 12;82(1):157

Changes of m(6)A Regulatory Proteins and Nrf2 Signaling Molecules in Liver Tissue of Type 2 Diabetes Mellitus Rats.

Wang N, Yang J, Liu X, Liu G, He Z, Gu S
Cell biochemistry and biophysics 2024 Sep;82(3):2217-2226

YTHDC2 mediated RNA m(6)A modification contributes to PM(2.5)-induced hepatic steatosis.

Yan Z, Zhang Y, Nan N, Ji S, Lan S, Qin G, Sang N
Journal of hazardous materials 2024 Sep 5;476:135004

A homozygous missense variant in YTHDC2 induces azoospermia in two siblings.

Tian S, Faheem M, Satti HS, Xiao J, Zhang F, Khan TN, Liu C
Molecular genetics and genomics : MGG 2024 Sep 2;299(1):84

Changes of RNA m(6)A/m(5)C Modification Regulatory Molecules in Ferroptosis of T2DM Rat Pancreas.

Liu X, Wang N, Gu S, He Z
Cell biochemistry and biophysics 2024 Jun;82(2):1279-1289

Inhibition of METTL3 in macrophages provides protection against intestinal inflammation.

Yin H, Ju Z, Zhang X, Zuo W, Yang Y, Zheng M, Zhang X, Liu Y, Peng Y, Xing Y, Yang A, Zhang R
Cellular & molecular immunology 2024 Jun;21(6):589-603

The m(6)A reader YTHDC2 regulates UVB-induced DNA damage repair and histone modification.

Yang Z, Verghese M, Yang S, Shah P, He YY
Photochemistry and photobiology 2024 Jul-Aug;100(4):1031-1040

ALKBH5 promotes the development of lung adenocarcinoma by regulating the polarization of M2 macrophages through CDCA4.

Tan J, Chen F, Wang J, Li J, Ouyang B, Li X, Li Y, Zhang W, Jiang Y
Gene 2024 Feb 15;895:147975

Fat mass and obesity-associated protein (FTO) mediated m(6)A modification of circFAM192A promoted gastric cancer proliferation by suppressing SLC7A5 decay.

Wu X, Fang Y, Gu Y, Shen H, Xu Y, Xu T, Shi R, Xu D, Zhang J, Leng K, Shu Y, Ma P
Molecular biomedicine 2024 Apr 1;5(1):11

Enzymolysis-based RNA pull-down identifies YTHDC2 as an inhibitor of antiviral innate response.

Zhu J, Liu S, Fang J, Cui Z, Wang B, Wang Y, Liu L, Wang Q, Cao X
Cell reports 2023 Oct 31;42(10):113192

LIMK1 m(6)A-RNA methylation recognized by YTHDC2 induces 5-FU chemoresistance in colorectal cancer via endoplasmic reticulum stress and stress granule formation.

Chen L, Sun K, Qin W, Huang B, Wu C, Chen J, Lai Q, Wang X, Zhou R, Li A, Liu S, Zhang Y
Cancer letters 2023 Nov 1;576:216420

Super-enhancer RNA m(6)A promotes local chromatin accessibility and oncogene transcription in pancreatic ductal adenocarcinoma.

Li R, Zhao H, Huang X, Zhang J, Bai R, Zhuang L, Wen S, Wu S, Zhou Q, Li M, Zeng L, Zhang S, Deng S, Su J, Zuo Z, Chen R, Lin D, Zheng J
Nature genetics 2023 Dec;55(12):2224-2234

YTHDC2 inhibits rat bone mesenchymal stem cells osteogenic differentiation by accelerating RUNX2 mRNA degradation via m6A methylation.

Ma B, Cao P, Zhang L, Zhu H, Ye X, Wang L, Chen L
Heliyon 2023 Aug;9(8):e18876

Alphaherpesvirus-mediated remodeling of the cellular transcriptome results in depletion of m6A-containing transcripts.

Jansens RJJ, Olarerin-George A, Verhamme R, Mirza A, Jaffrey S, Favoreel HW
iScience 2023 Aug 18;26(8):107310

YTHDC2 Promotes Malignant Phenotypes of Breast Cancer Cells.

Tanabe A, Nakayama T, Kashiyanagi J, Yamaga H, Hirohashi Y, Torigoe T, Satomi F, Shima H, Maeda H, Kutomi G, Takemasa I, Sahara H
Journal of oncology 2022;2022:9188920

m(6)A modification confers thermal vulnerability to HPV E7 oncotranscripts via reverse regulation of its reader protein IGF2BP1 upon heat stress.

Wang L, Zhan G, Maimaitiyiming Y, Su Y, Lin S, Liu J, Su K, Lin J, Shen S, He W, Wang F, Chen J, Sun S, Xue Y, Gu J, Chen X, Zhang J, Zhang L, Wang Q, Chang KJ, Chiou SH, Björklund M, Naranmandura H, Cheng X, Hsu CH
Cell reports 2022 Oct 25;41(4):111546

m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial-mesenchymal transition of lung cancer cells.

Suphakhong K, Terashima M, Wanna-Udom S, Takatsuka R, Ishimura A, Takino T, Suzuki T
The Journal of biological chemistry 2022 Nov;298(11):102554

Systematic analysis of the expression profile and prognostic significance of m6A regulators and PD-L1 in hepatocellular carcinoma.

Kong F, Wang K, Wang L
Discover oncology 2022 Nov 25;13(1):131

Fusobacterium nucleatum reduces METTL3-mediated m(6)A modification and contributes to colorectal cancer metastasis.

Chen S, Zhang L, Li M, Zhang Y, Sun M, Wang L, Lin J, Cui Y, Chen Q, Jin C, Li X, Wang B, Chen H, Zhou T, Wang L, Hsu CH, Zhuo W
Nature communications 2022 Mar 10;13(1):1248

Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.

Li Z, Xu Q, Huangfu N, Chen X, Zhu J
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019

Protective role of m(6)A binding protein YTHDC2 on CCNB2 in manganese-induced spermatogenesis dysfunction.

Qi Z, Liu Y, Yang H, Yang X, Wang H, Liu B, Yuan Y, Wang G, Xu B, Liu W, Xu Z, Deng Y
Chemico-biological interactions 2022 Jan 5;351:109754

The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1.

Li M, Zhong X, Zhao Z, Zeng Z, Yuan Q, Xiao X, Zu X, Liu J
Brain research 2022 Feb 15;1777:147766

YTHDC2 control of gametogenesis requires helicase activity but not m(6)A binding.

Saito Y, Hawley BR, Puno MR, Sarathy SN, Lima CD, Jaffrey SR, Darnell RB, Keeney S, Jain D
Genes & development 2022 Feb 1;36(3-4):180-194

Regulation of telomere homeostasis and genomic stability in cancer by N (6)-adenosine methylation (m(6)A).

Lee JH, Hong J, Zhang Z, de la Peña Avalos B, Proietti CJ, Deamicis AR, Guzmán G P, Lam HM, Garcia J, Roudier MP, Sisk AE, De La Rosa R, Vu K, Yang M, Liao Y, Scheirer J, Pechacek D, Yadav P, Rao MK, Zheng S, Johnson-Pais TL, Leach RJ, Elizalde PV, Dray E, Xu K
Science advances 2021 Jul;7(31)

Genetic variants in m6A modification genes are associated with esophageal squamous-cell carcinoma in the Chinese population.

Yang N, Ying P, Tian J, Wang X, Mei S, Zou D, Peng X, Gong Y, Yang Y, Zhu Y, Ke J, Zhong R, Chang J, Miao X
Carcinogenesis 2020 Jul 10;41(6):761-768

YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.

Sheng H, Li Z, Su S, Sun W, Zhang X, Li L, Li J, Liu S, Lu B, Zhang S, Shan C
Carcinogenesis 2020 Jul 10;41(5):541-550

Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis.

Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E
Molecular cell 2020 Dec 3;80(5):876-891.e6

Critical roles of mRNA m(6)A modification and YTHDC2 expression for meiotic initiation and progression in female germ cells.

Zeng M, Dai X, Liang Z, Sun R, Huang S, Luo L, Li Z
Gene 2020 Aug 30;753:144810

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