25671-1-AP

antibody from Proteintech Group

Targeting: CHCHD10 C22orf16, MIX17A, N27C7-4

Provider product page for 25671-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [18]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

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Product number: 25671-1-AP - Provider product page
Provider: Proteintech Group
Product name: CHCHD10 antibody
Antibody type: Polyclonal
Description: KD/KO validated CHCHD10 antibody (Cat. #25671-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CHCHD10 protein structure - 25671-1-AP shown in red.

Submitted references Loss of CHCHD2 Stability Coordinates with C1QBP/CHCHD2/CHCHD10 Complex Impairment to Mediate PD-Linked Mitochondrial Dysfunction.

Ren YL, Jiang Z, Wang JY, He Q, Li SX, Gu XJ, Qi YR, Zhang M, Yang WJ, Cao B, Li JY, Wang Y, Chen YP
Molecular neurobiology 2024 Oct;61(10):7968-7988

Mitochondrial protein CHCHD10 inhibits NDV replication and reduces pathological changes.

Yu X, Jiang H, Li J, Ding J, Wu T, Chen K, Ding Z, Xu X
Veterinary microbiology 2024 Mar;290:109986

High fat diet ameliorates mitochondrial cardiomyopathy in CHCHD10 mutant mice.

Southwell N, Manzo O, Bacman S, Zhao D, Sayles NM, Dash J, Fujita K, D'Aurelio M, Di Lorenzo A, Manfredi G, Kawamata H
EMBO molecular medicine 2024 Jun;16(6):1352-1378

The identification of high-performing antibodies for Coiled-coil-helix-coiled-coil-helix domain containing protein 10 (CHCHD10) for use in Western Blot, immunoprecipitation and immunofluorescence.

Ayoubi R, Alshafie W, Southern K, McPherson PS, Laflamme C, NeuroSGC/YCharOS/EDDU collaborative group
F1000Research 2023;12:403

CHCHD10 Modulates Thermogenesis of Adipocytes by Regulating Lipolysis.

Ding M, Ma YJ, Du RQ, Zhou WY, Dou X, Yang QQ, Tang Y, Qian SW, Liu Y, Pan DN, Tang QQ, Liu Y
Diabetes 2022 Sep 1;71(9):1862-1879

Mouse midbrain dopaminergic neurons survive loss of the PD-associated mitochondrial protein CHCHD2.

Nguyen MK, McAvoy K, Liao SC, Doric Z, Lo I, Li H, Manfredi G, Nakamura K
Human molecular genetics 2022 May 4;31(9):1500-1518

Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy.

Sayles NM, Southwell N, McAvoy K, Kim K, Pesini A, Anderson CJ, Quinzii C, Cloonan S, Kawamata H, Manfredi G
Cell reports 2022 Mar 8;38(10):110475

Modulation of miR-181 influences dopaminergic neuronal degeneration in a mouse model of Parkinson's disease.

Stein CS, McLendon JM, Witmer NH, Boudreau RL
Molecular therapy. Nucleic acids 2022 Jun 14;28:1-15

CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response.

Ruan Y, Hu J, Che Y, Liu Y, Luo Z, Cheng J, Han Q, He H, Zhou Q
Cell death & disease 2022 Feb 16;13(2):156

Human Placental Endothelial Cell and Trophoblast Heterogeneity and Differentiation Revealed by Single-Cell RNA Sequencing.

Li H, Peng H, Hong W, Wei Y, Tian H, Huang X, Jia L, Zheng J, Duan T, He Q, Wang K
Cells 2022 Dec 25;12(1)

TDP-43 and PINK1 mediate CHCHD10(S59L) mutation-induced defects in Drosophila and in vitro.

Baek M, Choe YJ, Bannwarth S, Kim J, Maitra S, Dorn GW 2nd, Taylor JP, Paquis-Flucklinger V, Kim NC
Nature communications 2021 Mar 26;12(1):1924

Loss of mitochondrial protein CHCHD10 in skeletal muscle causes neuromuscular junction impairment.

Xiao Y, Zhang J, Shu X, Bai L, Xu W, Wang A, Chen A, Tu WY, Wang J, Zhang K, Luo B, Shen C
Human molecular genetics 2020 Jul 21;29(11):1784-1796

CHCHD10 is involved in the development of Parkinson's disease caused by CHCHD2 loss-of-function mutation p.T61I.

Mao C, Wang H, Luo H, Zhang S, Xu H, Zhang S, Rosenblum J, Wang Z, Zhang Q, Tang M, Shepard MJ, Wang X, Wang Y, Zhuang Z, Shi C, Xu Y
Neurobiology of aging 2019 Mar;75:38-41

Single-cell transcriptomes reveal molecular specializations of neuronal cell types in the developing cerebellum.

Peng J, Sheng AL, Xiao Q, Shen L, Ju XC, Zhang M, He ST, Wu C, Luo ZG
Journal of molecular cell biology 2019 Aug 19;11(8):636-648

PD-linked CHCHD2 mutations impair CHCHD10 and MICOS complex leading to mitochondria dysfunction.

Zhou W, Ma D, Sun AX, Tran HD, Ma DL, Singh BK, Zhou J, Zhang J, Wang D, Zhao Y, Yen PM, Goh E, Tan EK
Human molecular genetics 2019 Apr 1;28(7):1100-1116

Loss of CHCHD10-CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS.

Straub IR, Janer A, Weraarpachai W, Zinman L, Robertson J, Rogaeva E, Shoubridge EA
Human molecular genetics 2018 Jan 1;27(1):178-189

CHCHD10 mutations p.R15L and p.G66V cause motoneuron disease by haploinsufficiency.

Brockmann SJ, Freischmidt A, Oeckl P, Müller K, Ponna SK, Helferich AM, Paone C, Reinders J, Kojer K, Orth M, Jokela M, Auranen M, Udd B, Hermann A, Danzer KM, Lichtner P, Walther P, Ludolph AC, Andersen PM, Otto M, Kursula P, Just S, Weishaupt JH
Human molecular genetics 2018 Feb 15;27(4):706-715

Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity.

Woo JA, Liu T, Trotter C, Fang CC, De Narvaez E, LePochat P, Maslar D, Bukhari A, Zhao X, Deonarine A, Westerheide SD, Kang DE
Nature communications 2017 Jun 6;8:15558

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse heart tissue were subjected to SDS PAGE followed by western blot with 25671-1-AP( CHCHD10 Antibody) at dilution of 1:600
Other comments: WB
Appendix: 25671-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of A431 cells using 25671-1-AP( CHCHD10 Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Other comments: IF
Appendix: 25671-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemistry of paraffin-embedded human heart tissue slide using 25671-1-AP( CHCHD10 Antibody) at dilution of 1:50 (under 10x lens)
Other comments: IHC
Appendix: 25671-1-AP.pdf

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