Antibody data
- Antibody Data
- Antigen structure
- References [15]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 13497-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13497-1-AP, RRID:AB_2157176
- Product name
- OTX2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated OTX2 antibody (Cat. #13497-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Binge-Like Ethanol Drinking Increases Otx2, Wnt1, and Mdk Gene Expression in the Ventral Tegmental Area of Adult Mice.
Sox6 expression distinguishes dorsally and ventrally biased dopamine neurons in the substantia nigra with distinctive properties and embryonic origins.
A transcriptome atlas of the mouse iris at single-cell resolution defines cell types and the genomic response to pupil dilation.
OTX2 regulates CFTR expression during endoderm differentiation and occupies 3' cis-regulatory elements.
Cis-regulatory dissection of cone development reveals a broad role for Otx2 and Oc transcription factors.
Effective Inhibition of MYC-Amplified Group 3 Medulloblastoma Through Targeting EIF4A1.
Reversing a model of Parkinson's disease with in situ converted nigral neurons.
ZIC3 Controls the Transition from Naive to Primed Pluripotency.
DMBX1 promotes tumor proliferation and regulates cell cycle progression via repressing OTX2-mediated transcription of p21 in lung adenocarcinoma cell.
Molecular network of miR-1343 regulates the pluripotency of porcine pluripotent stem cells via repressing OTX2 expression.
Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease.
Inhibition of Cdk5 rejuvenates inhibitory circuits and restores experience-dependent plasticity in adult visual cortex.
Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2.
Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes.
Otx2 and Oct4 drive early enhancer activation during embryonic stem cell transition from naive pluripotency.
Coles C, Lasek AW
Neuroscience insights 2021;16:26331055211009850
Neuroscience insights 2021;16:26331055211009850
Sox6 expression distinguishes dorsally and ventrally biased dopamine neurons in the substantia nigra with distinctive properties and embryonic origins.
Pereira Luppi M, Azcorra M, Caronia-Brown G, Poulin JF, Gaertner Z, Gatica S, Moreno-Ramos OA, Nouri N, Dubois M, Ma YC, Ramakrishnan C, Fenno L, Kim YS, Deisseroth K, Cicchetti F, Dombeck DA, Awatramani R
Cell reports 2021 Nov 9;37(6):109975
Cell reports 2021 Nov 9;37(6):109975
A transcriptome atlas of the mouse iris at single-cell resolution defines cell types and the genomic response to pupil dilation.
Wang J, Rattner A, Nathans J
eLife 2021 Nov 16;10
eLife 2021 Nov 16;10
OTX2 regulates CFTR expression during endoderm differentiation and occupies 3' cis-regulatory elements.
Kerschner JL, Paranjapye A, NandyMazumdar M, Yin S, Leir SH, Harris A
Developmental dynamics : an official publication of the American Association of Anatomists 2021 May;250(5):684-700
Developmental dynamics : an official publication of the American Association of Anatomists 2021 May;250(5):684-700
Cis-regulatory dissection of cone development reveals a broad role for Otx2 and Oc transcription factors.
Lonfat N, Wang S, Lee C, Garcia M, Choi J, Park PJ, Cepko C
Development (Cambridge, England) 2021 May 1;148(9)
Development (Cambridge, England) 2021 May 1;148(9)
Effective Inhibition of MYC-Amplified Group 3 Medulloblastoma Through Targeting EIF4A1.
Zhao Y, Li T, Tian S, Meng W, Sui Y, Yang J, Wang B, Liang Z, Zhao H, Han Y, Tang Y, Zhang L, Ma J
Cancer management and research 2020;12:12473-12485
Cancer management and research 2020;12:12473-12485
Reversing a model of Parkinson's disease with in situ converted nigral neurons.
Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD
Nature 2020 Jun;582(7813):550-556
Nature 2020 Jun;582(7813):550-556
ZIC3 Controls the Transition from Naive to Primed Pluripotency.
Yang SH, Andrabi M, Biss R, Murtuza Baker S, Iqbal M, Sharrocks AD
Cell reports 2019 Jun 11;27(11):3215-3227.e6
Cell reports 2019 Jun 11;27(11):3215-3227.e6
DMBX1 promotes tumor proliferation and regulates cell cycle progression via repressing OTX2-mediated transcription of p21 in lung adenocarcinoma cell.
Luo J, Liu K, Yao Y, Sun Q, Zheng X, Zhu B, Zhang Q, Xu L, Shen Y, Ren B
Cancer letters 2019 Jul 1;453:45-56
Cancer letters 2019 Jul 1;453:45-56
Molecular network of miR-1343 regulates the pluripotency of porcine pluripotent stem cells via repressing OTX2 expression.
Xie Y, Cao H, Zhang Z, Zhang S, Wang H
RNA biology 2019 Jan;16(1):82-92
RNA biology 2019 Jan;16(1):82-92
Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease.
Wang YK, Zhu WW, Wu MH, Wu YH, Liu ZX, Liang LM, Sheng C, Hao J, Wang L, Li W, Zhou Q, Hu BY
Stem cell reports 2018 Jul 10;11(1):171-182
Stem cell reports 2018 Jul 10;11(1):171-182
Inhibition of Cdk5 rejuvenates inhibitory circuits and restores experience-dependent plasticity in adult visual cortex.
Li Y, Wang L, Zhang X, Huang M, Li S, Wang X, Chen L, Jiang B, Yang Y
Neuropharmacology 2018 Jan;128:207-220
Neuropharmacology 2018 Jan;128:207-220
Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2.
Peña CJ, Kronman HG, Walker DM, Cates HM, Bagot RC, Purushothaman I, Issler O, Loh YE, Leong T, Kiraly DD, Goodman E, Neve RL, Shen L, Nestler EJ
Science (New York, N.Y.) 2017 Jun 16;356(6343):1185-1188
Science (New York, N.Y.) 2017 Jun 16;356(6343):1185-1188
Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes.
Johann PD, Erkek S, Zapatka M, Kerl K, Buchhalter I, Hovestadt V, Jones DTW, Sturm D, Hermann C, Segura Wang M, Korshunov A, Rhyzova M, Gröbner S, Brabetz S, Chavez L, Bens S, Gröschel S, Kratochwil F, Wittmann A, Sieber L, Geörg C, Wolf S, Beck K, Oyen F, Capper D, van Sluis P, Volckmann R, Koster J, Versteeg R, von Deimling A, Milde T, Witt O, Kulozik AE, Ebinger M, Shalaby T, Grotzer M, Sumerauer D, Zamecnik J, Mora J, Jabado N, Taylor MD, Huang A, Aronica E, Bertoni A, Radlwimmer B, Pietsch T, Schüller U, Schneppenheim R, Northcott PA, Korbel JO, Siebert R, Frühwald MC, Lichter P, Eils R, Gajjar A, Hasselblatt M, Pfister SM, Kool M
Cancer cell 2016 Mar 14;29(3):379-393
Cancer cell 2016 Mar 14;29(3):379-393
Otx2 and Oct4 drive early enhancer activation during embryonic stem cell transition from naive pluripotency.
Yang SH, Kalkan T, Morissroe C, Marks H, Stunnenberg H, Smith A, Sharrocks AD
Cell reports 2014 Jun 26;7(6):1968-81
Cell reports 2014 Jun 26;7(6):1968-81
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Y79 cells were subjected to SDS PAGE followed by western blot with 13497-1-AP(OTX2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human gliomas using 13497-1-AP(OTX2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human gliomas using 13497-1-AP(OTX2 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue