HPA045119

antibody from Atlas Antibodies

Targeting: MPC1 BRP44L, CGI-129, dJ68L15.3, SLC54A1

Provider product page for HPA045119

Western blot

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [22]
Comments [0]
Validations
Immunohistochemistry [1]

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Product number: HPA045119 - Provider product page
Provider: Atlas Antibodies
Proper citation: Atlas Antibodies Cat#HPA045119, RRID:AB_10960421
Product name: Anti-MPC1
Antibody type: Polyclonal
Description: Polyclonal Antibody against Human MPC1, Gene description: mitochondrial pyruvate carrier 1, Alternative Gene Names: BRP44L, CGI-129, dJ68L15.3, Validated applications: WB, IHC, ICC, Uniprot ID: Q9Y5U8, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µl
Concentration: 0.1 mg/ml
Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Handling: The antibody solution should be gently mixed before use.

MPC1 protein structure - HPA045119 shown in red.

Submitted references E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development

Di Michele M, Attina A, Roux P, Tabet I, Laguesse S, Florido J, Houdeville M, Choquet A, Encislai B, Arena G, De Blasio C, Wendling O, Frenois F, Papon L, Stuani L, Fuentes M, Jahannault Talignani C, Rousseau M, Guégan J, Buscail Y, Dupré P, Michaud H, Rodier G, Bellvert F, Kulyk H, Ferraro Peyret C, Mathieu H, Close P, Rapino F, Chaveroux C, Pirot N, Rubio L, Torro A, Sorg T, Ango F, Hirtz C, Compan V, Lebigot E, Legati A, Ghezzi D, Nguyen L, David A, Sardet C, Lacroix M, Le Cam L
Nature Communications 2025;16(1)

Association of Mitochondrial Pyruvate Carrier with the Clinical and Histological Features in Lupus Nephritis

Zhu H, Chen C, Geng L, Li Q, Zhang C, Wu L, Zhang B, Duan S, Xing C, Yuan Y
International Journal of Nephrology and Renovascular Disease 2024;Volume 17

Glucose-derived glutamate drives neuronal terminal differentiation in vitro

D’Andrea L, Audano M, Pedretti S, Pelucchi S, Stringhi R, Imperato G, De Cesare G, Cambria C, Laporte M, Zamboni N, Antonucci F, Di Luca M, Mitro N, Marcello E
EMBO Reports 2024;25(3):991-1021

Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles

Ali H, Karasinska J, Topham J, Johal D, Kalloger S, Metcalfe A, Warren C, Miyagi A, Tao L, Kevorkova M, Chafe S, McDonald P, Dedhar S, Parker S, Renouf D, Schaeffer D
Cancer & Metabolism 2024;12(1)

Tiwari A, Myeong J, Hashemiaghdam A, Zhang H, Niu X, Laramie M, Stunault M, Sponagel J, Patti G, Shriver L, Klyachko V, Ashrafi G
2024

Mitochondrial pyruvate metabolism regulates the activation of quiescent adult neural stem cells

Petrelli F, Scandella V, Montessuit S, Zamboni N, Martinou J, Knobloch M
Science Advances 2023;9(9)

Zlatic S, Werner E, Surapaneni V, Lee C, Gokhale A, Singleton K, Duong D, Crocker A, Gentile K, Middleton F, Dalloul J, Liu W, Patgiri A, Tarquinio D, Carpenter R, Faundez V
2023

mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity

Zhang K, Yao E, Chuang E, Chen B, Chuang E, Chuang P
Nature Communications 2022;13(1)

Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency

Astori S, Laporte M, De La Rossa A, Marissal T, Montessuit S, Sheshadri P, Ramos-Fernández E, Mendez P, Khani A, Quairiaux C, Taylor E, Rutter J, Nunes J, Carleton A, Duchen M, Sandi C, Martinou J
eLife 2022;11

Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria

Zhang K, Yao E, Chen B, Chuang E, Wong J, Seed R, Nishimura S, Wolters P, Chuang P
eLife 2022;11

Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content

Hartwig C, Méndez G, Bhattacharjee S, Vrailas-Mortimer A, Zlatic S, Freeman A, Gokhale A, Concilli M, Werner E, Sapp Savas C, Rudin-Rush S, Palmer L, Shearing N, Margewich L, McArthy J, Taylor S, Roberts B, Lupashin V, Polishchuk R, Cox D, Jorquera R, Faundez V
The Journal of Neuroscience 2021;41(2):215-233

A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma

Choi J, Sebastian C, Ferrer C, Lewis C, Sade-Feldman M, LaSalle T, Gonye A, Lopez B, Abdelmoula W, Regan M, Cetinbas M, Pascual G, Wojtkiewicz G, Silveira G, Boon R, Ross K, Tirosh I, Saladi S, Ellisen L, Sadreyev R, Benitah S, Agar N, Hacohen N, Mostoslavsky R
Nature Metabolism 2021;3(2):182-195

Mitochondrial pyruvate carrier: a potential target for diabetic nephropathy

Zhu H, Wan H, Wu L, Li Q, Liu S, Duan S, Huang Z, Zhang C, Zhang B, Xing C, Yuan Y
BMC Nephrology 2020;21(1)

Mitochondrial fusion is required for spermatogonial differentiation and meiosis

Varuzhanyan G, Rojansky R, Sweredoski M, Graham R, Hess S, Ladinsky M, Chan D
eLife 2019;8

Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin

Flores A, Sandoval-Gonzalez S, Takahashi R, Krall A, Sathe L, Wei L, Radu C, Joly J, Graham N, Christofk H, Lowry W
Nature Communications 2019;10(1)

Pioglitazone inhibits mitochondrial pyruvate metabolism and glucose production in hepatocytes

Shannon C, Daniele G, Galindo C, Abdul‐Ghani M, DeFronzo R, Norton L
The FEBS Journal 2017;284(3):451-465

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism

Schell J, Wisidagama D, Bensard C, Zhao H, Wei P, Tanner J, Flores A, Mohlman J, Sorensen L, Earl C, Olson K, Miao R, Waller T, Delker D, Kanth P, Jiang L, DeBerardinis R, Bronner M, Li D, Cox J, Christofk H, Lowry W, Thummel C, Rutter J
Nature Cell Biology 2017;19(9):1027-1036

Lactate dehydrogenase activity drives hair follicle stem cell activation

Flores A, Schell J, Krall A, Jelinek D, Miranda M, Grigorian M, Braas D, White A, Zhou J, Graham N, Graeber T, Seth P, Evseenko D, Coller H, Rutter J, Christofk H, Lowry W
Nature Cell Biology 2017;19(9):1017-1026

Mitochondrial pyruvate carrier function is negatively linked to Warburg phenotype in vitro and malignant features in esophageal squamous cell carcinomas

Li Y, Li X, Kan Q, Zhang M, Li X, Xu R, Wang J, Yu D, Goscinski M, Wen J, Nesland J, Suo Z
Oncotarget 2016;8(1):1058-1073

MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells

Vanderperre B, Cermakova K, Escoffier J, Kaba M, Bender T, Nef S, Martinou J
Journal of Biological Chemistry 2016;291(32):16448-16461

Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet

Larsson N, Vanderperre B, Herzig S, Krznar P, Hörl M, Ammar Z, Montessuit S, Pierredon S, Zamboni N, Martinou J
PLOS Genetics 2016;12(5):e1006056

E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity

Lacroix M, Rodier G, Kirsh O, Houles T, Delpech H, Seyran B, Gayte L, Casas F, Pessemesse L, Heuillet M, Bellvert F, Portais J, Berthet C, Bernex F, Brivet M, Boutron A, Le Cam L, Sardet C
Proceedings of the National Academy of Sciences 2016;113(39):10998-11003

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Supportive validation

Submitted by: Atlas Antibodies (provider)
Enhanced method: Orthogonal validation
Main image
Experimental details: Immunohistochemistry analysis in human heart muscle and pancreas tissues using HPA045119 antibody. Corresponding MPC1 RNA-seq data are presented for the same tissues.
Sample type: Human
Protocol: Protocol
Orthogonal method: Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.

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