SPINK9

The protein encoded by this gene is a Kazal-type serine protease inhibitor that appears to specifically target kallikrein-related peptidase 5 (KLK5) in the palmo-plantar epidermis. KLK5 is an important initiator of skin desquamation, so the encoded protease inhibitor may regulate skin differentiation in the palms of hands and soles of feet. This cationic protein has also been shown to promote keratinocyte migration by activation of the epidermal growth factor receptor (EGFR). [provided by RefSeq, Dec 2015]

Description

Serine peptidase inhibitor Kazal type 9

Tissue specificity

Tissue enhanced (brain)

Subcell location

Nucleoplasm, Vesicles

Predicted location

Intracellular, Secreted in other tissues

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins

Chromosome

5 (148321203 - 148339852)

Ensembl ID

ENSG00000204909  (ver. 103.38)

Orthologs

-

UniProt

Q5DT21

neXtProt

NX_Q5DT21

Human splice variants

Protein structure