28445-1-AP

antibody from Proteintech Group

Targeting: PGAM5 BXLBv68, MGC5352

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Antibody Data

Product number

28445-1-AP

Provider

Proteintech Group

Product name

PGAM5 antibody

Antibody type

Polyclonal

Description

PGAM5 antibody (Cat. #28445-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human and has been validated for the following applications: IF, WB,ELISA.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease.

Lu H, Zhu Y, Wang X, Wu Z, Xu Z, Chen R, Guo Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(13):e15138

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PGAM5 modulates PI3K/AKT/mTOR-dependent mitochondrial homeostasis in sepsis-induced acute kidney injury.

Jin X, Sheng L, Jiang D, Tian D, Jia H, Wu X
Toxicology and applied pharmacology 2026 Jun;511:117812

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Procyanidin Capsules Combat ALF by Restoring Mitochondrial Homeostasis and Inhibiting Necroptosis via the PGAM5/DRP1/PINK1 Pathway.

Shi Q, Wu M, Zhong J, Chen C, Huang Z, Peng J, Yang D, Zan X, Wang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(7):e08742

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Novel mechanism of neuronal hypoxia response: HIF-1α/STOML2 mediated PINK1-dependent mitophagy activation against neuronal injury.

Li Y, Xu Z, Tian Z, Guo M, Shao Q, Liu Y, Gu Y, Jin F, Ji X, Liu J
Cell death discovery 2026 Feb 21;12(1)

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TRIM25 triggers pyroptosis through mitochondrial DNA release in intestinal ischemia-reperfusion injury.

Song Y, Lu X, Ren X, Li M, Meng F, Miao Y, Ding D, Liu Y
Free radical biology & medicine 2026 Apr;247:333-347

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Cu-Mn Bimetallic Mesoporous Silica Nanosonosensitizers Enable Oxeiptosis-Mediated Sonodynamic Therapy for Ultra-Minimally Invasive Treatment of Benign Prostatic Hyperplasia.

Chang M, Lv J, Sun L, Chen A, Zhang F, Fan G, Liu Z, Li J, Shen H, Shi M, Niu Y, Tian Y, Liu X, Yang B
ACS applied materials & interfaces 2025 Sep 17;17(37):51820-51839

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The ubiquitin-binding protein ANKRD13A mediates VCP-dependent mitochondrial outer membrane rupture during PINK1/Parkin-mediated mitophagy.

Chu WH, Lin YS, Guo J, Jane WN, Wang WJ, Lin YY, Liu PH, Huang PY, Chiang WC
The Journal of biological chemistry 2025 Nov;301(11):110739

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GSTK1 suppresses HCC aggravation via L-carnitine metabolism by PGAM5/DRP1 complex-mediated mitochondrial quality control.

Shi Y, Zhang J, Song B, Zhang H, He J, Ding K, Wang F, Yu W, Zhangyuan G, Jin K, Zhang W, Sun B
Journal of experimental & clinical cancer research : CR 2025 Nov 24;45(1):1

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Cleaving PINK1 or PGAM5? Involvement of PARL in Methamphetamine-Induced Excessive Mitophagy and Neuronal Necroptosis.

An D, Zhang C, Zhou P, Wang Y, Meng S, Chen Y, Xu W, Xuan J, Xiong J, Cheng J, Gao R, Wang J, Chen X
CNS neuroscience & therapeutics 2025 Feb;31(2):e70293

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Comparative mitochondrial proteomic: PGAM5-mediated necroptosis through excessive mitophagy in sheep livers under molybdenum and cadmium co-exposure.

Xiong Z, Yang F, Dai X, Xing C, Bai H, Liu L, Wang Y, Cao H
Journal of hazardous materials 2025 Feb 5;483:136686

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p16(INK4a) promoted progress of MCT induced pulmonary hypertension via maintaining redox balance and autophagy pathway.

Wang F, Xiao W, Li J, Zhang Z, Zhang X, Sun J, Zhong Y, Wang X, Zhuang R, Gu X
Biochemical and biophysical research communications 2025 Feb 16;749:151385

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Decabromodiphenyl ethane exposure-mediated mitochondrial dysfunction drives oxeiptosis in placental trophoblasts and induces fetal growth restriction.

Xie L, Liu H, Hu X, Xu J, Chao B, Wang J, Sun L, Liu X, Zhou N, Sun L, Qi H, Luo X
Journal of environmental management 2025 Apr;379:124775

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METTL3 Plays Regulatory Roles in Acute Pneumonia during Staphylococcus aureus Infection.

Wu M, Nie Q, Zhang Y, Qin J, Ye L, Zhao R, Dai M, Wu M
ACS infectious diseases 2025 Apr 11;11(4):905-916

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LFHP-1c improves cognitive function after TBI in mice by reducing oxidative stress through the PGAM5-NRF2-KEAP1 ternary complex.

Shao W, Wang JJ, Niu ZH, Zhang K, Wang S, Wang YH, Tang YH, Wang CC, Hou SQ, Zhou DR, Zhang C, Lin N
Heliyon 2024 Sep 15;10(17):e36820

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Ponicidin Promotes Hepatocellular Carcinoma Mitochondrial Apoptosis by Stabilizing Keap1-PGAM5 Complex.

Zhao B, Liang Z, Zhang L, Jiang L, Xu Y, Zhang Y, Zhang R, Wang C, Liu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(38):e2406080

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Antioxidant aromatic compounds from Amomum villosum and target prediction of active ingredients.

Liang J, Xu Y, Chen J, Zhang Z, Wang H, Liu K, Sun D, Li H, Chen L
Bioorganic chemistry 2024 Jun;147:107375

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Erythroid-intrinsic activation of TLR8 impairs erythropoiesis in inherited anemia.

Liang J, Wan Y, Gao J, Zheng L, Wang J, Wu P, Li Y, Wang B, Wang D, Ma Y, Shen B, Lv X, Wang D, An N, Ma X, Geng G, Tong J, Liu J, Chen G, Gao M, Kurita R, Nakamura Y, Zhu P, Yin H, Zhu X, Shi L
Nature communications 2024 Jul 6;15(1):5678

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High-fat diet-induced L-saccharopine accumulation inhibits estradiol synthesis and damages oocyte quality by disturbing mitochondrial homeostasis.

Wen J, Feng Y, Xue L, Yuan S, Chen Q, Luo A, Wang S, Zhang J
Gut microbes 2024 Jan-Dec;16(1):2412381

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Identification and validation of protein biomarkers for predicting gastrointestinal stromal tumor recurrence.

Sun J, Li J, He Y, Kang W, Ye X
Computational and structural biotechnology journal 2024 Dec;23:1065-1075

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4-Octyl itaconate inhibits inflammation to attenuate psoriasis as an agonist of oxeiptosis.

You M, Jiang Q, Huang H, Ma F, Zhou X
International immunopharmacology 2023 Nov;124(Pt B):110915

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PGAM5 degrades PDCoV N protein and activates type I interferon to antagonize viral replication.

Yang X, Kong N, Qin W, Zhai X, Song Y, Tong W, Li L, Liu C, Zheng H, Yu H, Zhang W, Tong G, Shan T
Journal of virology 2023 Nov 30;97(11):e0147023

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TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury.

Zhong WJ, Zhang J, Duan JX, Zhang CY, Ma SC, Li YS, Yang NS, Yang HH, Xiong JB, Guan CX, Jiang ZX, You ZJ, Zhou Y
Journal of translational medicine 2023 Mar 6;21(1):179

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Emodin-Induced Necroptosis in Prostate Cancer Cells via the Mitochondrial Fission HSP90/MLKL/PGAM Pathway.

Zhou X, Yeasmin Khusbu F, Xie Y, Yang P
Chemistry & biodiversity 2023 Jun;20(6):e202201130

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Selenium alleviates cadmium-induced mitophagy through FUNDC1-mediated mitochondrial quality control pathway in the lungs of sheep.

Lin S, Yang F, Hu M, Chen J, Chen G, Hu A, Li X, Fu D, Xing C, Xiong Z, Wu Y, Cao H
Environmental pollution (Barking, Essex : 1987) 2023 Feb 15;319:120954

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Epoxyeicosatrienoic acids alleviate alveolar epithelial cell senescence by inhibiting mitophagy through NOX4/Nrf2 pathway.

Hong JR, Zhang CY, Zhong WJ, Yang HH, Xiong JB, Deng P, Yang NS, Chen H, Jin L, Guan CX, Duan JX, Zhou Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115937

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Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in mice.

Li L, Guo C, Yu Y, Tie L, Lu G, Liu F, Han X, Ji L, Zou X
Cell & bioscience 2023 Aug 21;13(1):154

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PGAM5 deacetylation mediated by SIRT2 facilitates lipid metabolism and liver cancer proliferation.

Fu G, Li ST, Jiang Z, Mao Q, Xiong N, Li X, Hao Y, Zhang H
Acta biochimica et biophysica Sinica 2023 Aug 15;55(9):1370-1379

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The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer.

Cheng M, Yu H, Kong Q, Wang B, Shen L, Dong D, Sun L
International journal of molecular sciences 2022 Jan 25;23(3)

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Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease.

Alavi MV
Biochimica et biophysica acta. Molecular cell research 2021 Nov;1868(12):119116