PRMT9

This gene encodes a type II methyltransferase. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to the guanidino nitrogen atoms of arginine. The protein encoded by this gene methylates spliceosome associated protein 145 to regulate alternative splicing and acts as a modulator of small nuclear ribonucleoprotein maturation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2017]

Description

Protein arginine methyltransferase 9

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Microtubules, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (147637785 - 147684163)

Ensembl ID

ENSG00000164169  (ver. 103.38)

Orthologs

Mouse Prmt9: ENSMUSG00000037134

UniProt

Q6P2P2

neXtProt

NX_Q6P2P2

Human splice variants
Mouse splice variants

Protein structure