TGFBRAP1

This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF-beta. It is involved in signal-dependent association with SMAD4. The protein is also a component of mammalian CORVET, a multisubunit tethering protein complex that is involved in fusion of early endosomes. [provided by RefSeq, Jun 2016]

Description

Transforming growth factor beta receptor associated protein 1

Tissue specificity

Low tissue specificity

Subcell location

Vesicles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (105264391 - 105329735)

Ensembl ID

ENSG00000135966  (ver. 103.38)

Orthologs

Mouse Tgfbrap1: ENSMUSG00000070939

UniProt

Q8WUH2

neXtProt

NX_Q8WUH2

Human splice variants
Mouse splice variants

Protein structure