Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS6249 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- DEFB121 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human DEFB121.
- Description
- ÉÇ-defensins (also designated BDs, or hBDs in human) are small cationic peptides with broad-spectrum antimicrobial activity against a variety of enveloped viruses, fungi and bacteria. Produced in mucosal epithelia and neutrophils of several species, ÉÇ-defensins are developmentally regulated. The family of ÉÇ-defensin proteins share a common defensin-motif that is characterized by multiple cysteine residues and a highly conserved tertiary structure. Besides playing a significant role in host immune defense, many ÉÇ-defensins also are involved in sperm maturation and capacitation. ÉÇ-defensin 121 is a 76 amino acid secreted protein that most likely contains a signal peptide sequence that requires cleavage by proteolytic enzymes in order to become biologically active. While expressed at low levels in testis, ÉÇ-defensin 121 is abundantly expressed in epididymal caput and corpus and, unlike other ÉÇ-defensins, it does not appear to be regulated by androgens.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot analysis of extracts from HepG2 cell, using DEFB121 antibody.