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- Antigen structure
- References [11]
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- Product number
- 13685-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- BCKDHB antibody
- Antibody type
- Polyclonal
- Description
- BCKDHB antibody (Cat. #13685-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Inhibition of CDH11 Activates cGAS-STING by Stimulating Branched Chain Amino Acid Catabolism and Mitigates Lung Metastasis of Adenoid Cystic Carcinoma.
BCKDHA-BCKDHB digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease.
Integrative proteogenomic profiling of high-risk prostate cancer samples from Chinese patients indicates metabolic vulnerabilities and diagnostic biomarkers.
Integrated machine learning and bioinformatic analysis of mitochondrial-related signature in chronic rhinosinusitis with nasal polyps.
Mitolnc controls cardiac BCAA metabolism and heart hypertrophy by allosteric activation of BCKDH.
CPT1A loss disrupts BCAA metabolism to confer therapeutic vulnerability in TP53-mutated liver cancer.
Branched-chain amino acids promote thrombocytopoiesis by activating mTOR signaling.
AMPK induces degradation of the transcriptional repressor PROX1 impairing branched amino acid metabolism and tumourigenesis.
Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression.
SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis.
MiR-330-5p negatively regulates ovine preadipocyte differentiation by targeting branched-chain aminotransferase 2.
Li RF, Liu S, Gao Q, Fu M, Sun XY, Xiao M, Ge XY, Peng X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(8):e2408751
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(8):e2408751
BCKDHA-BCKDHB digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease.
Wang J, Poskitt LE, Gallagher J, Puffenberger EG, Wynn RM, Shishodia G, Chuang DT, Beever J, Hardin DL, Brigatti KW, Baker WC, Gately R, Bertrand S, Rodrigues A, Benatti HR, Taghian T, Hall E, Prestigiacomo R, Liang J, Chen G, Zhou X, Ren L, Liu N, He R, Su Q, Xie J, Jiang Z, Gruntman A, Gray-Edwards H, Gao G, Strauss KA, Wang D
Science translational medicine 2025 Feb 26;17(787):eads0539
Science translational medicine 2025 Feb 26;17(787):eads0539
Integrative proteogenomic profiling of high-risk prostate cancer samples from Chinese patients indicates metabolic vulnerabilities and diagnostic biomarkers.
Dong B, Xu JY, Huang Y, Guo J, Dong Q, Wang Y, Li N, Liu Q, Zhang M, Pan Q, Wang H, Jiang J, Chen B, Shen D, Ma Y, Zhai L, Zhang J, Li J, Xue W, Tan M, Qin J
Nature cancer 2024 Sep;5(9):1427-1447
Nature cancer 2024 Sep;5(9):1427-1447
Integrated machine learning and bioinformatic analysis of mitochondrial-related signature in chronic rhinosinusitis with nasal polyps.
Yang B, Gu M, Hong C, Zou XY, Zhang JQ, Yuan Y, Qiu CY, Lu MP, Cheng L
The World Allergy Organization journal 2024 Oct;17(10):100964
The World Allergy Organization journal 2024 Oct;17(10):100964
Mitolnc controls cardiac BCAA metabolism and heart hypertrophy by allosteric activation of BCKDH.
Weiss M, Hettrich S, Hofmann T, Hachim S, Günther S, Braun T, Boettger T
Nucleic acids research 2024 Jun 24;52(11):6629-6646
Nucleic acids research 2024 Jun 24;52(11):6629-6646
CPT1A loss disrupts BCAA metabolism to confer therapeutic vulnerability in TP53-mutated liver cancer.
Liu Y, Wang F, Yan G, Tong Y, Guo W, Li S, Qian Y, Li Q, Shu Y, Zhang L, Zhang Y, Xia Q
Cancer letters 2024 Jul 28;595:217006
Cancer letters 2024 Jul 28;595:217006
Branched-chain amino acids promote thrombocytopoiesis by activating mTOR signaling.
Jiang H, Zhang L, Yang M, Li G, Ding C, Xin M, Dai J, Sun X, Fan X, Sun H, Liu J, Xu Y
Journal of thrombosis and haemostasis : JTH 2023 Nov;21(11):3224-3235
Journal of thrombosis and haemostasis : JTH 2023 Nov;21(11):3224-3235
AMPK induces degradation of the transcriptional repressor PROX1 impairing branched amino acid metabolism and tumourigenesis.
Wang Y, Luo M, Wang F, Tong Y, Li L, Shu Y, Qiao K, Zhang L, Yan G, Liu J, Ji H, Xie Y, Zhang Y, Gao WQ, Liu Y
Nature communications 2022 Nov 24;13(1):7215
Nature communications 2022 Nov 24;13(1):7215
Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression.
Yang D, Liu H, Cai Y, Lu K, Zhong X, Xing S, Song W, Zhang Y, Ye L, Zhu X, Wang T, Zhang P, Li ST, Feng J, Jia W, Zhang H, Gao P
Cell reports 2022 Nov 22;41(8):111691
Cell reports 2022 Nov 22;41(8):111691
SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis.
Zaganjor E, Yoon H, Spinelli JB, Nunn ER, Laurent G, Keskinidis P, Sivaloganathan S, Joshi S, Notarangelo G, Mulei S, Chvasta MT, Tucker SA, Kalafut K, van de Ven RAH, Clish CB, Haigis MC
Cell reports 2021 Jul 13;36(2):109345
Cell reports 2021 Jul 13;36(2):109345
MiR-330-5p negatively regulates ovine preadipocyte differentiation by targeting branched-chain aminotransferase 2.
Shi T, Yan X, Qiao L, Li B, Cheng L, Pan Y, Jing J, Cao N, Liu W
Animal science journal = Nihon chikusan Gakkaiho 2018 Jun;89(6):858-867
Animal science journal = Nihon chikusan Gakkaiho 2018 Jun;89(6):858-867
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BCKDHB antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human BCKDHB. This antibody recognizes human,mouse,rat antigen. The BCKDHB antibody has been validated for the following applications: ELISA, WB analysis.
