Antibody data
- Antibody Data
- Antigen structure
- References [67]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
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- Product number
- 17785-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17785-1-AP, RRID:AB_2271365
- Product name
- Synaptophysin antibody
- Antibody type
- Polyclonal
- Description
- Synaptophysin antibody (Cat. #17785-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The circRNA circ-Nbea participates in regulating diabetic encephalopathy.
Traumatic Brain Injury Accelerates the Onset of Cognitive Dysfunction and Aggravates Alzheimer's-Like Pathology in the Hippocampus by Altering the Phenotype of Microglia in the APP/PS1 Mouse Model.
Nicotinamide Improves Cognitive Function in Mice With Chronic Cerebral Hypoperfusion.
Postconditioning with Sevoflurane or Propofol Alleviates Lipopolysaccharide-Induced Neuroinflammation but Exerts Dissimilar Effects on the NR2B Subunit and Cognition.
Liraglutide Alleviates Cognitive Deficit in db/db Mice: Involvement in Oxidative Stress, Iron Overload, and Ferroptosis.
Abnormal spatiotemporal expression pattern of progranulin and neurodevelopment impairment in VPA-induced ASD rat model.
YAP drives fate conversion and chemoresistance of small cell lung cancer.
DSCAM deficiency leads to premature spine maturation and autism-like behaviors.
Iptakalim alleviates synaptic damages via targeting mitochondrial ATP-sensitive potassium channel in depression.
Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.
Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease.
Histone demethylase PHF8 drives neuroendocrine prostate cancer progression by epigenetically upregulating FOXA2.
FOXO3 Regulates Sevoflurane-Induced Neural Stem Cell Differentiation in Fetal Rats.
Hippocampal LASP1 ameliorates chronic stress-mediated behavioral responses in a mouse model of unpredictable chronic mild stress.
Enriched environment remedies cognitive dysfunctions and synaptic plasticity through NMDAR-Ca2+-Activin A circuit in chronic cerebral hypoperfusion rats.
Haploinsufficiency of the TDP43 ubiquitin E3 ligase RNF220 leads to ALS-like motor neuron defects in the mouse.
Quantitative proteomic analysis of cortex in the depressive-like behavior of rats induced by the simulated complex space environment.
Curcumin Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors via Restoring Changes in Oxidative Stress and the Activation of Nrf2 Signaling Pathway in Rats.
Xiaoyao Pills Attenuate Inflammation and Nerve Injury Induced by Lipopolysaccharide in Hippocampal Neurons In Vitro.
Transplantation of Stem Cells from Human Exfoliated Deciduous Teeth Decreases Cognitive Impairment from Chronic Cerebral Ischemia by Reducing Neuronal Apoptosis in Rats.
Bisphenol-A exposure induced neurotoxicity and associated with synapse and cytoskeleton in Neuro-2a cells.
Identification and immunohistochemical characterization of G-quadruplexes in mouse brain.
Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice.
The Neurotrophic Function of Glucagon-Like Peptide-1 Promotes Human Neuroblastoma Differentiation via the PI3K-AKT Axis.
Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells.
The critical role of the hippocampal NLRP3 inflammasome in social isolation-induced cognitive impairment in male mice.
NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.
Small dose of L-dopa/Benserazide hydrochloride improved sepsis-induced neuroinflammation and long-term cognitive dysfunction in sepsis mice.
Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia.
Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer's Disease Pathogenesis in Cell and Animal Models.
Fingolimod (FTY720) improves postoperative cognitive dysfunction in mice subjected to D-galactose-induced aging.
Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2.
Cryopreservation of a Human Brain and Its Experimental Correlate in Rats.
Corticosterone Induced the Increase of proBDNF in Primary Hippocampal Neurons Via Endoplasmic Reticulum Stress.
Subcutaneous administration of β-hydroxybutyrate improves learning and memory of sepsis surviving mice.
Xiaoyao Pills Prevent Lipopolysaccharide-Induced Depression by Inhibiting Inflammation and Protecting Nerves.
MicroRNA-99a is a Potential Target for Regulating Hypothalamic Synaptic Plasticity in the Peri/Postmenopausal Depression Model.
Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer's disease.
Neuroprotective effects of a Smoothened receptor agonist against postoperative cognitive dysfunction by promoting autophagy in the dentate gyrus of aged rats.
Cinnamic acid rescues behavioral deficits in a mouse model of traumatic brain injury by targeting miR-455-3p/HDAC2.
SMCR8 negatively regulates AKT and MTORC1 signaling to modulate lysosome biogenesis and tissue homeostasis.
Absence of BBSome function leads to astrocyte reactivity in the brain.
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE.
Chronic fluoride exposure induces neuronal apoptosis and impairs neurogenesis and synaptic plasticity: Role of GSK-3β/β-catenin pathway.
PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by influencing synaptic function in the primary motor cortex of rats.
A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets.
Cadmium induces actin cytoskeleton alterations and dysfunction in Neuro-2a cells.
Brain-Derived Neurotrophic Factor Precursor in the Hippocampus Regulates Both Depressive and Anxiety-Like Behaviors in Rats.
Mesenchymal Stem Cell-Derived Exosomes Reduce A1 Astrocytes via Downregulation of Phosphorylated NFκB P65 Subunit in Spinal Cord Injury.
Metformin Inhibits Prostate Cancer Progression by Targeting Tumor-Associated Inflammatory Infiltration.
Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury.
Rodent Neural Progenitor Cells Support Functional Recovery after Cervical Spinal Cord Contusion.
Pin1 mediates Aβ42-induced dendritic spine loss.
Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease.
Quantitative proteomics study of host response to virulent and attenuated pseudorabies virus infection in mouse brain.
Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury.
Pre-existing weakness is critical for the occurrence of postoperative cognitive dysfunction in mice of the same age.
Sepsis-induced selective loss of NMDA receptors modulates hippocampal neuropathology in surviving septic mice.
Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models.
Aqua-soluble DDQ reduces the levels of Drp1 and Aβ and inhibits abnormal interactions between Aβ and Drp1 and protects Alzheimer's disease neurons from Aβ- and Drp1-induced mitochondrial and synaptic toxicities.
The effects of fluoride on neuronal function occurs via cytoskeleton damage and decreased signal transmission.
Chronic administration of parecoxib exerts anxiolytic-like and memory enhancing effects and modulates synaptophysin expression in mice.
Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters.
Identification of TMEM230 mutations in familial Parkinson's disease.
Identification of protein network alterations upon retinal ischemia-reperfusion injury by quantitative proteomics using a Rattus norvegicus model.
Effect of treadmill exercise on 5-HT, 5-HT1A receptor and brain derived neurophic factor in rats after permanent middle cerebral artery occlusion.
Liu J, Deng Z, Yu Z, Zhou W, Yuan Q
Brain research 2022 Jan 1;1774:147702
Brain research 2022 Jan 1;1774:147702
Traumatic Brain Injury Accelerates the Onset of Cognitive Dysfunction and Aggravates Alzheimer's-Like Pathology in the Hippocampus by Altering the Phenotype of Microglia in the APP/PS1 Mouse Model.
Wu D, Kumal JPP, Lu X, Li Y, Mao D, Tang X, Nie M, Liu X, Sun L, Liu B, Zhang Y
Frontiers in neurology 2021;12:666430
Frontiers in neurology 2021;12:666430
Nicotinamide Improves Cognitive Function in Mice With Chronic Cerebral Hypoperfusion.
Liu B, Zhao G, Jin L, Shi J
Frontiers in neurology 2021;12:596641
Frontiers in neurology 2021;12:596641
Postconditioning with Sevoflurane or Propofol Alleviates Lipopolysaccharide-Induced Neuroinflammation but Exerts Dissimilar Effects on the NR2B Subunit and Cognition.
Liu H, Chen B, Guo B, Deng X, Wang B, Dou X
Molecular neurobiology 2021 Sep;58(9):4251-4267
Molecular neurobiology 2021 Sep;58(9):4251-4267
Liraglutide Alleviates Cognitive Deficit in db/db Mice: Involvement in Oxidative Stress, Iron Overload, and Ferroptosis.
An JR, Su JN, Sun GY, Wang QF, Fan YD, Jiang N, Yang YF, Shi Y
Neurochemical research 2021 Sep 4;
Neurochemical research 2021 Sep 4;
Abnormal spatiotemporal expression pattern of progranulin and neurodevelopment impairment in VPA-induced ASD rat model.
Lan J, Hu Y, Wang X, Zheng W, Liao A, Wang S, Li Y, Wang Y, Yang F, Chen D
Neuropharmacology 2021 Sep 15;196:108689
Neuropharmacology 2021 Sep 15;196:108689
YAP drives fate conversion and chemoresistance of small cell lung cancer.
Wu Q, Guo J, Liu Y, Zheng Q, Li X, Wu C, Fang D, Chen X, Ma L, Xu P, Xu X, Liao C, Wu M, Shen L, Song H
Science advances 2021 Oct;7(40):eabg1850
Science advances 2021 Oct;7(40):eabg1850
DSCAM deficiency leads to premature spine maturation and autism-like behaviors.
Chen P, Liu Z, Zhang Q, Lin D, Lu S, Liu J, Jiao HF, Lai X, Zou S, Wang S, Zhou T, Li BM, Zhu L, Pan BX, Fei E
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Nov 29;
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Nov 29;
Iptakalim alleviates synaptic damages via targeting mitochondrial ATP-sensitive potassium channel in depression.
Guo W, Tang ZY, Cai ZY, Zhao WE, Yang J, Wang XP, Ji J, Huang XX, Sun XL
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21581
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21581
Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.
Li X, Zhang J, Li D, He C, He K, Xue T, Wan L, Zhang C, Liu Q
Neuron 2021 Mar 17;109(6):957-970.e8
Neuron 2021 Mar 17;109(6):957-970.e8
Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease.
Zou L, Zhang X, Xiong M, Meng L, Tian Y, Pan L, Yuan X, Chen G, Wang Z, Bu L, Yao Z, Zhang Z, Ye K, Zhang Z
Neurobiology of disease 2021 Jul;154:105326
Neurobiology of disease 2021 Jul;154:105326
Histone demethylase PHF8 drives neuroendocrine prostate cancer progression by epigenetically upregulating FOXA2.
Liu Q, Pang J, Wang LA, Huang Z, Xu J, Yang X, Xie Q, Huang Y, Tang T, Tong D, Liu G, Wang L, Zhang D, Ma Q, Xiao H, Lan W, Qin J, Jiang J
The Journal of pathology 2021 Jan;253(1):106-118
The Journal of pathology 2021 Jan;253(1):106-118
FOXO3 Regulates Sevoflurane-Induced Neural Stem Cell Differentiation in Fetal Rats.
Li X, Jiang X, Gao Q, Zhao P
Cellular and molecular neurobiology 2021 Feb 19;
Cellular and molecular neurobiology 2021 Feb 19;
Hippocampal LASP1 ameliorates chronic stress-mediated behavioral responses in a mouse model of unpredictable chronic mild stress.
Cui YH, Fu A, Wang XQ, Tu BX, Chen KZ, Wang YK, Hu QG, Wang LF, Hu ZL, Pan PH, Li F, Bi FF, Li CQ
Neuropharmacology 2021 Feb 15;184:108410
Neuropharmacology 2021 Feb 15;184:108410
Enriched environment remedies cognitive dysfunctions and synaptic plasticity through NMDAR-Ca2+-Activin A circuit in chronic cerebral hypoperfusion rats.
Zhang X, Shi X, Wang J, Xu Z, He J
Aging 2021 Aug 30;13(16):20748-20761
Aging 2021 Aug 30;13(16):20748-20761
Haploinsufficiency of the TDP43 ubiquitin E3 ligase RNF220 leads to ALS-like motor neuron defects in the mouse.
Ma P, Li Y, Wang H, Mao B
Journal of molecular cell biology 2021 Aug 18;13(5):374-382
Journal of molecular cell biology 2021 Aug 18;13(5):374-382
Quantitative proteomic analysis of cortex in the depressive-like behavior of rats induced by the simulated complex space environment.
Min R, Chen Z, Wang Y, Deng Z, Zhang Y, Deng Y
Journal of proteomics 2021 Apr 15;237:104144
Journal of proteomics 2021 Apr 15;237:104144
Curcumin Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors via Restoring Changes in Oxidative Stress and the Activation of Nrf2 Signaling Pathway in Rats.
Liao D, Lv C, Cao L, Yao D, Wu Y, Long M, Liu N, Jiang P
Oxidative medicine and cellular longevity 2020;2020:9268083
Oxidative medicine and cellular longevity 2020;2020:9268083
Xiaoyao Pills Attenuate Inflammation and Nerve Injury Induced by Lipopolysaccharide in Hippocampal Neurons In Vitro.
Fang Y, Shi B, Liu X, Luo J, Rao Z, Liu R, Zeng N
Neural plasticity 2020;2020:8841332
Neural plasticity 2020;2020:8841332
Transplantation of Stem Cells from Human Exfoliated Deciduous Teeth Decreases Cognitive Impairment from Chronic Cerebral Ischemia by Reducing Neuronal Apoptosis in Rats.
Zhu S, Min D, Zeng J, Ju Y, Liu Y, Chen X
Stem cells international 2020;2020:6393075
Stem cells international 2020;2020:6393075
Bisphenol-A exposure induced neurotoxicity and associated with synapse and cytoskeleton in Neuro-2a cells.
Yin Z, Hua L, Chen L, Hu D, Li J, An Z, Tian T, Ning H, Ge Y
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104911
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104911
Identification and immunohistochemical characterization of G-quadruplexes in mouse brain.
Asamitsu S, Imai Y, Yabuki Y, Ikenoshita S, Takeuchi M, Kashiwagi H, Tanoue Y, Fukuda T, Shioda N
Biochemical and biophysical research communications 2020 Oct 8;531(1):67-74
Biochemical and biophysical research communications 2020 Oct 8;531(1):67-74
Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice.
Feng T, Mai S, Roscoe JM, Sheng RR, Ullah M, Zhang J, Katz II, Yu H, Xiong W, Hu F
EMBO reports 2020 Oct 5;21(10):e50219
EMBO reports 2020 Oct 5;21(10):e50219
The Neurotrophic Function of Glucagon-Like Peptide-1 Promotes Human Neuroblastoma Differentiation via the PI3K-AKT Axis.
Yang JL, Lin YT, Chen WY, Yang YR, Sun SF, Chen SD
Biology 2020 Oct 22;9(11)
Biology 2020 Oct 22;9(11)
Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells.
Sun Y, He L, Wang T, Hua W, Qin H, Wang J, Wang L, Gu W, Li T, Li N, Liu X, Chen F, Tang L
Molecular neurobiology 2020 Nov;57(11):4628-4641
Molecular neurobiology 2020 Nov;57(11):4628-4641
The critical role of the hippocampal NLRP3 inflammasome in social isolation-induced cognitive impairment in male mice.
Niu L, Luo SS, Xu Y, Wang Z, Luo D, Yang H, Li W, He J, Zhong XL, Liu ZH, Zeng JY, Cao WY, Wan W
Neurobiology of learning and memory 2020 Nov;175:107301
Neurobiology of learning and memory 2020 Nov;175:107301
NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.
He X, Yang W, Zeng Z, Wei Y, Gao J, Zhang B, Li L, Liu L, Wan Y, Zeng Q, Gong Z, Liu L, Zhang H, Li Y, Yang S, Hu T, Wu L, Masliah E, Huang S, Cao H
Cellular & molecular immunology 2020 Mar;17(3):283-299
Cellular & molecular immunology 2020 Mar;17(3):283-299
Small dose of L-dopa/Benserazide hydrochloride improved sepsis-induced neuroinflammation and long-term cognitive dysfunction in sepsis mice.
Li F, Zhang B, Duan S, Qing W, Tan L, Chen S, Wang Y, Li D, Yang J, Tong J, Fang J, Le Y
Brain research 2020 Jun 15;1737:146780
Brain research 2020 Jun 15;1737:146780
Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia.
An JR, Zhao YS, Luo LF, Guan P, Tan M, Ji ES
Life sciences 2020 Jun 1;250:117573
Life sciences 2020 Jun 1;250:117573
Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer's Disease Pathogenesis in Cell and Animal Models.
Wei H, Zhang HL, Wang XC, Xie JZ, An DD, Wan L, Wang JZ, Zeng Y, Shu XJ, Westermarck J, Lu YM, Ohlmeyer M, Liu R
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Jul;17(3):1087-1103
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Jul;17(3):1087-1103
Fingolimod (FTY720) improves postoperative cognitive dysfunction in mice subjected to D-galactose-induced aging.
Zhang J, Xiao B, Li CX, Wang Y
Neural regeneration research 2020 Jul;15(7):1308-1315
Neural regeneration research 2020 Jul;15(7):1308-1315
Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2.
Escande-Beillard N, Loh A, Saleem SN, Kanata K, Hashimoto Y, Altunoglu U, Metoska A, Grandjean J, Ng FM, Pomp O, Baburajendran N, Wong J, Hill J, Beillard E, Cozzone P, Zaki M, Kayserili H, Hamada H, Shiratori H, Reversade B
Neuron 2020 Jul 8;107(1):82-94.e6
Neuron 2020 Jul 8;107(1):82-94.e6
Cryopreservation of a Human Brain and Its Experimental Correlate in Rats.
Canatelli-Mallat M, Lascaray F, Entraigues-Abramson M, Portiansky EL, Blamaceda N, Morel GR, Goya RG
Rejuvenation research 2020 Dec;23(6):516-525
Rejuvenation research 2020 Dec;23(6):516-525
Corticosterone Induced the Increase of proBDNF in Primary Hippocampal Neurons Via Endoplasmic Reticulum Stress.
Liu Y, Zou GJ, Tu BX, Hu ZL, Luo C, Cui YH, Xu Y, Li F, Dai RP, Bi FF, Li CQ
Neurotoxicity research 2020 Aug;38(2):370-384
Neurotoxicity research 2020 Aug;38(2):370-384
Subcutaneous administration of β-hydroxybutyrate improves learning and memory of sepsis surviving mice.
Wang X, Song Y, Chen J, Zhang S, Le Y, Xie Z, Ouyang W, Tong J
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Apr;17(2):616-626
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Apr;17(2):616-626
Xiaoyao Pills Prevent Lipopolysaccharide-Induced Depression by Inhibiting Inflammation and Protecting Nerves.
Shi B, Luo J, Fang Y, Liu X, Rao Z, Liu R, Zeng N
Frontiers in pharmacology 2019;10:1324
Frontiers in pharmacology 2019;10:1324
MicroRNA-99a is a Potential Target for Regulating Hypothalamic Synaptic Plasticity in the Peri/Postmenopausal Depression Model.
Yang J, Zhang L, Cao LL, Qi J, Li P, Wang XP, Sun XL
Cells 2019 Sep 13;8(9)
Cells 2019 Sep 13;8(9)
Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer's disease.
Zhou C, Sun X, Hu Y, Song J, Dong S, Kong D, Wang Y, Hua X, Han J, Zhou Y, Jin G, Yang X, Shi H, Zhang Z, Hua F
Aging 2019 Sep 11;11(17):7257-7273
Aging 2019 Sep 11;11(17):7257-7273
Neuroprotective effects of a Smoothened receptor agonist against postoperative cognitive dysfunction by promoting autophagy in the dentate gyrus of aged rats.
Li PJ, Guo YQ, Ding PY, Liu RB, Deng F, Feng XX, Yan WJ
Neurological research 2019 Oct;41(10):867-874
Neurological research 2019 Oct;41(10):867-874
Cinnamic acid rescues behavioral deficits in a mouse model of traumatic brain injury by targeting miR-455-3p/HDAC2.
Guo S, Zhen Y, Zhu Z, Zhou G, Zheng X
Life sciences 2019 Oct 15;235:116819
Life sciences 2019 Oct 15;235:116819
SMCR8 negatively regulates AKT and MTORC1 signaling to modulate lysosome biogenesis and tissue homeostasis.
Lan Y, Sullivan PM, Hu F
Autophagy 2019 May;15(5):871-885
Autophagy 2019 May;15(5):871-885
Absence of BBSome function leads to astrocyte reactivity in the brain.
Singh M, Garrison JE, Wang K, Sheffield VC
Molecular brain 2019 May 9;12(1):48
Molecular brain 2019 May 9;12(1):48
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
Shah SZA, Zhao D, Taglialatela G, Hussain T, Dong H, Sabir N, Mangi MH, Wu W, Lai M, Zhang X, Duan Y, Wang L, Zhou X, Yang L
International journal of molecular sciences 2019 Mar 6;20(5)
International journal of molecular sciences 2019 Mar 6;20(5)
SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE.
Raihan O, Brishti A, Li Q, Zhang Q, Li D, Li X, Zhang Q, Xie Z, Li J, Zhang J, Liu Q
Cell reports 2019 Jul 2;28(1):78-90.e6
Cell reports 2019 Jul 2;28(1):78-90.e6
Chronic fluoride exposure induces neuronal apoptosis and impairs neurogenesis and synaptic plasticity: Role of GSK-3β/β-catenin pathway.
Jiang P, Li G, Zhou X, Wang C, Qiao Y, Liao D, Shi D
Chemosphere 2019 Jan;214:430-435
Chemosphere 2019 Jan;214:430-435
PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by influencing synaptic function in the primary motor cortex of rats.
Mo J, Wang B, Zhu X, Wu X, Liu Y
Neurobiology of disease 2019 Jan;121:274-285
Neurobiology of disease 2019 Jan;121:274-285
A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets.
Sharon N, Chawla R, Mueller J, Vanderhooft J, Whitehorn LJ, Rosenthal B, Gürtler M, Estanboulieh RR, Shvartsman D, Gifford DK, Trapnell C, Melton D
Cell 2019 Feb 7;176(4):790-804.e13
Cell 2019 Feb 7;176(4):790-804.e13
Cadmium induces actin cytoskeleton alterations and dysfunction in Neuro-2a cells.
Ge Y, Song X, Chen L, Hu D, Hua L, Cui Y, Liu J, An Z, Yin Z, Ning H
Environmental toxicology 2019 Apr;34(4):469-475
Environmental toxicology 2019 Apr;34(4):469-475
Brain-Derived Neurotrophic Factor Precursor in the Hippocampus Regulates Both Depressive and Anxiety-Like Behaviors in Rats.
Zhong F, Liu L, Wei JL, Hu ZL, Li L, Wang S, Xu JM, Zhou XF, Li CQ, Yang ZY, Dai RP
Frontiers in psychiatry 2018;9:776
Frontiers in psychiatry 2018;9:776
Mesenchymal Stem Cell-Derived Exosomes Reduce A1 Astrocytes via Downregulation of Phosphorylated NFκB P65 Subunit in Spinal Cord Injury.
Wang L, Pei S, Han L, Guo B, Li Y, Duan R, Yao Y, Xue B, Chen X, Jia Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(4):1535-1559
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(4):1535-1559
Metformin Inhibits Prostate Cancer Progression by Targeting Tumor-Associated Inflammatory Infiltration.
Liu Q, Tong D, Liu G, Gao J, Wang LA, Xu J, Yang X, Xie Q, Huang Y, Pang J, Wang L, He Y, Zhang D, Ma Q, Lan W, Jiang J
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Nov 15;24(22):5622-5634
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Nov 15;24(22):5622-5634
Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury.
Ying Z, Pan C, Shao T, Liu L, Li L, Guo D, Zhang S, Yuan T, Cao R, Jiang Z, Chen S, Wang F, Wang X
Molecular cell 2018 Nov 1;72(3):457-468.e5
Molecular cell 2018 Nov 1;72(3):457-468.e5
Rodent Neural Progenitor Cells Support Functional Recovery after Cervical Spinal Cord Contusion.
Brock JH, Graham L, Staufenberg E, Im S, Tuszynski MH
Journal of neurotrauma 2018 May 1;35(9):1069-1078
Journal of neurotrauma 2018 May 1;35(9):1069-1078
Pin1 mediates Aβ42-induced dendritic spine loss.
Stallings NR, O'Neal MA, Hu J, Kavalali ET, Bezprozvanny I, Malter JS
Science signaling 2018 Mar 20;11(522)
Science signaling 2018 Mar 20;11(522)
Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease.
Reddy PH, Yin X, Manczak M, Kumar S, Pradeepkiran JA, Vijayan M, Reddy AP
Human molecular genetics 2018 Jul 15;27(14):2502-2516
Human molecular genetics 2018 Jul 15;27(14):2502-2516
Quantitative proteomics study of host response to virulent and attenuated pseudorabies virus infection in mouse brain.
Zeng HL, Yu FL, Zhang Z, Yang Q, Jin S, He X, Chen X, Shen Y, Cheng L, Guo L, Xu F
Biochimica et biophysica acta. Proteins and proteomics 2018 Feb;1866(2):307-315
Biochimica et biophysica acta. Proteins and proteomics 2018 Feb;1866(2):307-315
Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury.
Zhu L, Tang T, Fan R, Luo JK, Cui HJ, Zhang CH, Peng WJ, Sun P, Xiong XG, Wang Y
Neural regeneration research 2018 Aug;13(8):1417-1424
Neural regeneration research 2018 Aug;13(8):1417-1424
Pre-existing weakness is critical for the occurrence of postoperative cognitive dysfunction in mice of the same age.
Tang Y, Wang X, Zhang S, Duan S, Qing W, Chen G, Ye F, Le Y, Ouyang W
PloS one 2017;12(8):e0182471
PloS one 2017;12(8):e0182471
Sepsis-induced selective loss of NMDA receptors modulates hippocampal neuropathology in surviving septic mice.
Zhang S, Wang X, Ai S, Ouyang W, Le Y, Tong J
PloS one 2017;12(11):e0188273
PloS one 2017;12(11):e0188273
Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models.
Song Z, Shah SZA, Yang W, Dong H, Yang L, Zhou X, Zhao D
Frontiers in molecular neuroscience 2017;10:128
Frontiers in molecular neuroscience 2017;10:128
Aqua-soluble DDQ reduces the levels of Drp1 and Aβ and inhibits abnormal interactions between Aβ and Drp1 and protects Alzheimer's disease neurons from Aβ- and Drp1-induced mitochondrial and synaptic toxicities.
Kuruva CS, Manczak M, Yin X, Ogunmokun G, Reddy AP, Reddy PH
Human molecular genetics 2017 Sep 1;26(17):3375-3395
Human molecular genetics 2017 Sep 1;26(17):3375-3395
The effects of fluoride on neuronal function occurs via cytoskeleton damage and decreased signal transmission.
Chen L, Ning H, Yin Z, Song X, Feng Y, Qin H, Li Y, Wang J, Ge Y, Wang W
Chemosphere 2017 Oct;185:589-594
Chemosphere 2017 Oct;185:589-594
Chronic administration of parecoxib exerts anxiolytic-like and memory enhancing effects and modulates synaptophysin expression in mice.
Wang B, Jin X, Kuang X, Tian S
BMC anesthesiology 2017 Nov 13;17(1):152
BMC anesthesiology 2017 Nov 13;17(1):152
Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters.
Shah SZA, Zhao D, Taglialatela G, Khan SH, Hussain T, Dong H, Lai M, Zhou X, Yang L
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2017 Apr;14(2):463-483
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2017 Apr;14(2):463-483
Identification of TMEM230 mutations in familial Parkinson's disease.
Deng HX, Shi Y, Yang Y, Ahmeti KB, Miller N, Huang C, Cheng L, Zhai H, Deng S, Nuytemans K, Corbett NJ, Kim MJ, Deng H, Tang B, Yang Z, Xu Y, Chan P, Huang B, Gao XP, Song Z, Liu Z, Fecto F, Siddique N, Foroud T, Jankovic J, Ghetti B, Nicholson DA, Krainc D, Melen O, Vance JM, Pericak-Vance MA, Ma YC, Rajput AH, Siddique T
Nature genetics 2016 Jul;48(7):733-9
Nature genetics 2016 Jul;48(7):733-9
Identification of protein network alterations upon retinal ischemia-reperfusion injury by quantitative proteomics using a Rattus norvegicus model.
Tian H, Wang L, Cai R, Zheng L, Guo L
PloS one 2014;9(12):e116453
PloS one 2014;9(12):e116453
Effect of treadmill exercise on 5-HT, 5-HT1A receptor and brain derived neurophic factor in rats after permanent middle cerebral artery occlusion.
Lan X, Zhang M, Yang W, Zheng Z, Wu Y, Zeng Q, Liu S, Liu K, Li G
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2014 May;35(5):761-6
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2014 May;35(5):761-6
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 17785-1-AP(SYP antibody) at dilution of 1:1500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Synaptophysin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Synaptophysin. This antibody recognizes human,mouse,rat antigen. The Synaptophysin antibody has been validated for the following applications: ELISA, WB, IHC analysis.