Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [329]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 17785-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17785-1-AP, RRID:AB_2271365
- Product name
- Synaptophysin antibody
- Antibody type
- Polyclonal
- Description
- Synaptophysin antibody (Cat. #17785-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Novel LncRNA Gm44763 Regulates Morphine-Induced Reward Memory via MiR-298-5p-Mediated eIF4E Translation Control.
GSTA1 deficiency drives neuroendocrine differentiation via TNFRSF13B/c-FOS/CHGA axis in prostate cancer.
Astrocytic GSTM2-STAT3 interaction ameliorates the diabetes associated cognitive dysfunction via targeting mitochondrial defects and oxidative stress.
Tumor Prostate-Specific Antigen Density Can Predict Tumor Aggressiveness and Heterogeneity in Prostate Cancer.
Age-dependent elevation of Nr4a1 attenuates PI3K/AKT/GSK3β pathway and mediates tau hyperphosphorylation and cognitive impairments.
Clemastine ameliorates cognitive deficits in an experimental rat model of chronic cerebral hypoperfusion.
Insulin-like growth factor 2 alleviates metabolic inflammation and associated cognitive impairment in diet-induced obesity mice.
De-2-hydroxyisobutyrylation of clusterin modulates neuropathology and memory deficits in an Alzheimer's disease mouse model.
BMSC exosomes promote neurogenesis and alleviate behavioral deficits in chronic traumatic encephalopathy: an animal model-based study.
Discovery of Novel Pyrano[3,2-a]carbazole Alkaloid Derivatives against Ischemic Stroke by Targeting ADGRL3.
SMARCA4 promotes lineage plasticity and enzalutamide resistance in prostate cancer by regulating PROX1 via H3K27 acetylation.
Modeling spastic paraplegia 4 with corticospinal motor neuron-enriched cortical organoids reveals genotype-phenotype and HDAC6-targetable pathology.
Copper depletion ameliorates neuronal damage after intracerebral hemorrhage.
Abnormal FKN-CX3CR1-NR signal triggers hippocampal synaptic dysfunction in rheumatoid arthritis-related depression.
Methyl 3-chloroasterric acid exerted anti-neuroinflammatory and antidepressant effects through the downregulation of P2Y1R.
Astrocyte-Specific Nrf2 Expression Transforms Neurotoxic Reactive Astrocytes to Neuroprotective Phenotype in 3xTg-AD Mice.
Buyang Huanwu decoction facilitates the repair of red nucleus neurons subsequent to spinal cord injury in rats via autophagy.
Tuina Inhibits Synaptic Plasticity Through the Astrocytic NDRG2/GLT-1 Pathway to Alleviate Neuropathic Pain.
BST2 expression at astrocyte borders promotes microglial recruitment via the C3/C3aR signaling.
Hydrogel with cell-cell adhesion cues enhances neural regeneration.
Fibrinogen drives neuroinflammation and neuropathology in perioperative neurocognitive disorders.
Hydrogen-Mediated Activation of the Nrf2/HO-1 Signaling Pathway Improves Cognitive Impairment in Sleep-Deprived Mice.
IL-17A-mediated copper accumulation participates in chronic neuropathic pain-induced cognitive impairment by enhancing microglial synaptic pruning.
Long-Term Effects of Xenotransplantation of Human Enteric Glia in an Immunocompetent Rat Model of Acute Brain Injury.
UHRF1 regulates AR ubiquitination to promote the loss of AR signaling and enzalutamide resistance in progression of prostate cancer.
Simulated microgravity affects neuronal synaptic plasticity by regulating microglial pro-inflammatory activation.
Effects of Short-Term Exposure to Polystyrene Nanoplastics on the Nervous System: Calcium Homeostasis, BDNF and Synaptic Plasticity.
Circadian Rhythm Disorder-Related Dysfunctions are Exacerbated by Aging and Ameliorated by Time-Restricted Feeding.
UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration.
Design, synthesis, and investigation of anti-Alzheimer's activity and molecular mechanisms of phosphatidylserine derivatives.
Gut microbial metabolite indole-3-acetic acid inhibits microglia-mediated synaptic loss in Alzheimer's disease by targeting CCR4.
Probiotic supplementation attenuated early-life chemotherapy-induced brain development impairment in mice.
Research on the correlation between gut microbiota and brain cognitive function under chronic hypoxia at high altitude.
Photochemically induced thrombosis combined with chronic restraint stress for modeling post-stroke depression in mice.
Distinct neuroprotective and anti-inflammatory effects of Kampo formulas ninjinyoeito and juzentaihoto in depression-like SAMP8 mice.
N-acetyltransferase 10 in the nucleus accumbens participates in methamphetamine-induced conditioned place preference and hyperlocomotion in mice.
Role of Netrin-1 dysregulation in early neuronal pathology of α-synuclein models of Parkinson's disease.
Umbelliferone Alleviates Sleep Deprivation Induced Cognitive Impairment through the Modulation of Gut Microbiota.
The niacin receptor HCAR2 prevents sleep deprivation-induced cognitive impairment by inhibiting microglia-mediated neuroinflammation in mice.
The role of REST in regulating the BDNF/TrkB signalling pathway in nano-alumina induced cognitive dysfunction in zebrafish.
Cognitive impairment induced by psychological stress is time-of-day of exposure dependent in female rats.
Lactobacillus acidophilus promotes cognitive function recovery via regulating microglial peroxisomal function in cerebral ischemia.
Huang Lian Jie Du Decoction Prevents Chronic Alcoholic Encephalopathy and Improves Gut Microbiota Imbalance in Mice.
SFRS8 Regulates Memory by Modulating RNA Splicing of Synaptic Genes.
Design of the Hydrophobic Core of Self-Assembling Peptide Fibrils for Enhanced Neural Regeneration.
USP47 Regulates Excitatory Synaptic Plasticity and Modulates Seizures in Murine Models by Blocking Ubiquitinated AMPAR Degradation.
Molecular and immune characteristics of neuroendocrine bladder carcinoma - Implications for diagnosis, prognosis, and therapy: A review.
Air pollution decreases postsynaptic PSD-95 and NMDA receptor subunits in synaptosomes from mouse cerebral cortex.
Enriched environment ameliorates neurobehavioral abnormalities, hippocampal inflammation, and synaptic dysfunction in adult male mice exposed to intermittent hypoxia during pregnancy.
Single-cell RNA-seq reveals cell type-specific molecular and genetic associations with primary open-angle glaucoma.
Blood flow restriction training attenuates stroke-induced hippocampal ferroptosis, synaptic damage, and cognitive impairment via upregulating SIRT1 pathway.
Urolithin A improves Parkinson's disease-associated cognitive impairment through modulation of neuroinflammation and neuroplasticity.
Xanthouhumol relieves stress-induced depressive-like behaviors through the Sirt1/NF-κB/NLRP3 pathway.
Inhibition of spreading depolarizations by targeting GABA(A) receptors and voltage-gated sodium channels improves neurological deficits in rats with traumatic brain injury.
High glucose induces hippocampal neuron impairment through the SKP1/COX7C pathway: A potential mechanism for perimenopausal depression.
Chronic ethanol exposure induces hippocampal neuroinflammation and neuronal damage via the astrocytic RUNX1/TOLLIP/TLR3 pathway.
Nicotine Improves Memory Impairment in Aged Rats Through Enhanced Mitochondrial Homeostasis.
Peptide Photoimmobilization by Thiol-ene Chemistry for Enhanced Neural Cell Adhesion.
FGF21 Exhibits Neuroprotective Effects by Promoting 5-HT(1A)R-FGFR1 Heteroreceptor Complexes and Triggering MEK(1/2)-ERK(1/2) Signaling Pathway.
Nose-to-Brain Delivery of Circular RNA SCMH1-Loaded Lipid Nanoparticles for Ischemic Stroke Therapy.
Aerobic exercise improves astrocyte mitochondrial quality and transfer to neurons in a mouse model of Alzheimer's disease.
Misdiagnosis of esophageal leiomyoma combined with adrenal cortical adenoma as esophageal cancer with adrenal metastasis by fluorine-18-fluorodeoxyglucose positron emission tomography: A case report.
Distinct In Vitro Differentiation Protocols Differentially Affect Cytotoxicity Induced by Heavy Metals in Human Neuroblastoma SH-SY5Y Cells.
Co-exposure to ozone and polystyrene nanoplastic exacerbates cognitive impairment and anxiety-like behavior by regulating neuronal pyroptosis in mice.
MiR-29a-3p ameliorate behavioral deficiency in hypoxia-ischemia brain damage in neonatal mice by inhibiting BTG2.
Astrocyte-derived CCL5-mediated CCR5(+) neutrophil infiltration drives depression pathogenesis.
Basal-shift transformation leads to EGFR therapy-resistance in human lung adenocarcinoma.
Exercise-induced Activation of SIRT1/BDNF/mTORC1 Signaling Pathway: A Novel Mechanism to Reduce Neuroinflammation and Improve Post-stroke Depression.
Melatonin Alleviates Behavioral and Neurodevelopmental Abnormalities in Offspring Caused by Prenatal Stress.
Sequential Proteomic Analysis Reveals the Key APOE4-Induced Pathological and Molecular Features at the Presymptomatic Stage in Alzheimer's Disease Mice.
Exosome-Derived CDC42 From Hypoxia-Pretreated Neural Stem Cells Inhibits ACSL4-Related Ferroptosis to Alleviate Vascular Injury in Parkinson's Disease Mice Models.
Correlative light and electron microscopy imaging of proteinaceous deposits in cell cultures and brain tissues.
Muscone enhances synaptic function in vascular dementia through activating BDNF-TrkB-NP2 signaling pathway.
Olfactory bulb microglia activation mediates neuronal pyroptosis in ozone-exposed mice with olfactory and cognitive dysfunction.
Ginsenoside 1 mitigates postoperative cognitive dysfunction by enhancing microglial Aβ clearance through the endo-lysosomal pathway.
BOOST: a robust ten-fold expansion method on hour-scale.
FKBP51 is Involved in Epileptic Seizure by Regulating PSD95 in a PTZ-Induced Epileptic Mouse Model.
PD-like pathogenesis induced by intestinal exposure to microplastics: An in vivo study of animal models to a public health survey.
Role of FPR2 antagonism in alleviating social isolation-induced depression and protecting blood-brain barrier integrity.
LCN2 induces neuronal loss and facilitates sepsis-associated cognitive impairments.
Conductive MeCbl/PEDOT:PSS/HA hydrogels with electrical stimulation for enhanced peripheral nerve regeneration.
Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS-Induced Depressive-Like Behaviors.
GPR43 regulates mitochondrial apoptosis through the cyclophilin D pathway in Alzheimer's disease.
Aging-dependent YAP1 reduction contributes to AD pathology by upregulating the Nr4a1-AKT/GSK-3β axis.
Lactate links exercise to synaptic protection and cognitive enhancement in Alzheimer's disease models.
Icariin mitigates depressive-like behavior in rats by regulating mitochondrial function.
Exercise improves depressive-like behavior in adolescent mice by regulating sphingosine and ceramide metabolism through microglial CerS1.
Human neural stem cell-derived small extracellular vesicles enhance functional recovery after ischemic stroke through the miR-362-3p/MCAM/Wnt/β-catenin axis.
Lycium barbarum polysaccharide ameliorates corticosterone-induced cognition decline with modulation of CRHR1.
Flavonoids from Shiliangcha (Chimonanthus salicifolius) Alleviate Brain Aging in d-Galactose-Induced Senescent Mice through Gut Microbiota.
S-ketamine ameliorates post-stroke depression in mice via attenuation of neuroinflammation, synaptic restoration, and BDNF pathway activation.
Proteomics analysis reveals FEN1 as a promising therapeutic target against small cell neuroendocrine carcinoma of the cervix.
Ginsenoside Rg3 alleviates brain damage caused by chlorpyrifos exposure by targeting and regulating the microbial-gut-brain axis.
Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice.
Discovery of FO-4-15, a novel 1,2,4-oxadiazole derivative, ameliorates cognitive impairments in 3×Tg mice by activating the mGluR1/CaMKIIα pathway.
Magnolol acts as a neurorestorative agent in an A(β1‑42)‑induced mouse model of Alzheimer's disease.
Lycopene Alleviates Depression-Like Behavior in Chronic Social Defeat Stress-Induced Mice by Promoting Synaptic Plasticity via the BDNF-TrkB Pathway.
Minocycline ameliorates cognitive impairment in rats with trigeminal neuralgia by regulating microglial polarization.
Lentivirus-mediated overexpression of netrin-1/DCC co-expression promotes axonal regeneration and functional recovery in spinal cord injury via the inhibition of the NgR1-RhoA-ROCK signaling pathway.
VEGFD/VEGFR3 signaling contributes to the dysfunction of the astrocyte IL-3/microglia IL-3Rα cross-talk and drives neuroinflammation in mouse ischemic stroke.
MiR-18a-LncRNA NONRATG-022419 pairs targeted PRG-1 regulates diabetic induced cognitive impairment by regulating NGF\BDNF-Trkb signaling pathway.
Urolithin A alleviates NLRP3 inflammasome activation and pyroptosis by promoting microglial mitophagy following spinal cord injury.
Transplantation of medial ganglionic eminence cells rescues early-life stress-induced social and cognitive impairments in postnatal mice.
Gut dysbiosis-induced vitamin B6 metabolic disorder contributes to chronic stress-related abnormal behaviors in a cortisol-independent manner.
HCN2 promotes neurodevelopmental and synaptic function repair through the CaMKII/CREB pathway to alleviate general anesthesia-induced cognitive impairment.
OPRK1 drives SLC9A3R1 progression to neuroendocrine prostate cancer.
Astragaloside IV improves cognitive impairment in diabetes by inhibiting calpain-1/NLRP3 mediated microglial activation.
Subtle Alterations in Hippocampal Neuronal Activity Coincide With Early Sex-Specific Differences in Amyloidosis and Microglia in a Pre-Symptomatic Mouse Model of Alzheimer-Like Pathology.
Nomilin Alleviates Neuroinflammation and Depressive-like Behaviors in Mice through the Upregulation of TAX1BP1-Mediated Modulation of Microglia Polarization.
PPARα deletion induces depressive-like behaviors by impairing neuronal synaptic plasticity and transmission.
17β-Trenbolone modulates anxiety-related synaptic plasticity by affecting the interaction between hippocampal TACR3 and systemic testosterone in male mice.
FGF21 Alleviates Hypoxic-Ischemic White Matter Injury in Neonatal Mice by Mediating Inflammation and Oxidative Stress Through PPAR-γ Signaling Pathway.
Dietary salt promotes cognitive impairment through repression of SIRT3/PINK1-mediated mitophagy and fission.
Therapeutic Hypothermia Increases the Expression of RNA-binding Protein Motif 3 and Attenuates Cognitive Deficits Following Cardiac Arrest in Rats.
CRMP2 in the hippocampus alleviates chronic stress-induced depressive-like behaviours in mice by affecting synaptic function.
In vitro susceptibility of differentiated SH-SY5Y human neuroblastoma cells to herpes simplex virus type 1 and Japanese encephalitis virus infection.
The role of TFEB-mediated autophagy-lysosome dysfunction in manganese neurotoxicity.
Jujuboside A Regulates Calcium Homeostasis and Structural Plasticity to Alleviate Depression-Like Behavior via Shh Signaling in Immature Neurons.
Surgery induces neurocognitive disorder via neuroinflammation and glymphatic dysfunction in middle-aged mice with brain lymphatic drainage impairment.
Follicle-stimulating hormone induces depression-like phenotype by affecting synaptic function.
Enriched oxygen improves age-related cognitive impairment through enhancing autophagy.
The microglial innate immune receptor TREM2 participates in fear memory formation through excessive prelimbic cortical synaptic pruning.
Circular RNA SCMH1 suppresses KMO expression to inhibit mitophagy and promote functional recovery following stroke.
Sortilin is associated with progranulin deficiency and autism-like behaviors in valproic acid-induced autism rats.
Histone demethylase PHF8 promotes prostate cancer metastasis via the E2F1-SNAI1 axis.
Thy1-ApoE4/C/EBPβ double transgenic mice act as a sporadic model with Alzheimer's disease.
Wnt/Ca(2+) pathway inhibits neural differentiation of human dental pulp stem cells in vitro.
USP9X-mediated deubiquitination of Raptor contributes to autophagy impairment and memory deficits in P301S mice.
Corilagin improves cognitive impairment in APP/PS1 mice by reducing Aβ generation and enhancing synaptic plasticity.
The Neuroprotective Mechanisms of PPAR-γ: Inhibition of Microglia-Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic-Ischemic White Matter Injury.
LASP1 in the nucleus accumbens modulates methamphetamine-induced conditioned place preference in mice.
Shh regulates M2 microglial polarization and fibrotic scar formation after ischemic stroke.
S-ketamine alleviates depression-like behavior and hippocampal neuroplasticity in the offspring of mice that experience prenatal stress.
Inhibitory effect of tea flower polysaccharides on oxidative stress and microglial oxidative damage in aging mice by regulating gut microbiota.
Lentivirus-mediated Knockdown of Ski Improves Neurological Function After Spinal Cord Injury in Rats.
A peptide against the N-terminus of myristoylated alanine-rich C kinase substrate promotes neuronal differentiation in SH-SY5Y human neuroblastoma cells.
Oral edaravone ameliorates behavioral deficits and pathologies in a valproic acid-induced rat model of autism spectrum disorder.
Construction of functional neural network tissue combining CBD-NT3-modified linear-ordered collagen scaffold and TrkC-modified iPSC-derived neural stem cells for spinal cord injury repair.
Effects of autotaxin and lysophosphatidic acid deficiencies on depression-like behaviors in mice exposed to chronic unpredictable mild stress.
Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids.
Purinergic Astrocyte Signaling Driven by TNF-α After Cannabidiol Administration Restores Normal Synaptic Remodeling Following Traumatic Brain Injury.
Gut Microbiota Mediate the Neuroprotective Effect of Oolong Tea Polyphenols in Cognitive Impairment Induced by Circadian Rhythm Disorder.
PAX6 promotes neuroendocrine phenotypes of prostate cancer via enhancing MET/STAT5A-mediated chromatin accessibility.
Constraint-Induced Movement Therapy Modulates Neuron Recruitment and Neurotransmission Homeostasis of the Contralesional Cortex to Enhance Function Recovery after Ischemic Stroke.
The E3 ubiquitin ligase TRIM9 regulates synaptic function and actin dynamics in response to netrin-1.
Bilirubin impairs neuritogenesis and synaptogenesis in NSPCs by downregulating NMDAR-CREB-BDNF signaling.
Bavachin ameliorates neuroinflammation and depressive-like behaviors in streptozotocin-induced diabetic mice through the inhibition of PKCδ.
Dietary Restriction Improves Perioperative Neurocognitive Disorders by Inhibiting Neuroinflammation and Gut Microbial Dysbiosis.
Volatile oil of Angelica sinensis Radix improves cognitive function by inhibiting miR-301a-3p targeting Ppp2ca in cerebral ischemia mice.
Periplaneta Americana (L.) extract activates the ERK/CREB/BDNF pathway to promote post-stroke neuroregeneration and recovery of neurological functions in rats.
High salt diet induces cognitive impairment and is linked to the activation of IGF1R/mTOR/p70S6K signaling.
HDAC1/2/3-mediated downregulation of neurogranin is involved in cognitive impairment in offspring exposed to maternal subclinical hypothyroidism.
KIF1A, R1457Q, and P1688L Mutations Induce Protein Abnormal Aggregation and Autophagy Impairment in iPSC-Derived Motor Neurons.
PM2.5 triggers tau aggregation in a mouse model of tauopathy.
Targeting SOX4/PCK2 signaling suppresses neuroendocrine trans-differentiation of castration-resistant prostate cancer.
Apple polysaccharide improves age-matched cognitive impairment and intestinal aging through microbiota-gut-brain axis.
Pramipexole improves depression-like behavior in diabetes mellitus with depression rats by inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing impaired neuroplasticity.
Brassisterol A, a new ergosterol from co-cultivation of fungi attenuates neuroinflammation via targeting NLRP3/caspase-1/GSDMD pathway.
YTHDF3 modulates the Cbln1 level by recruiting BTG2 and is implicated in the impaired cognition of prenatal hypoxia offspring.
GR/Ahi1 regulates WDR68-DYRK1A binding and mediates cognitive impairment in prenatally stressed offspring.
The E3 ubiquitin ligase TRIM9 regulates synaptic function and actin dynamics.
Prednisolone improves hippocampal regeneration after trimethyltin-induced neurodegeneration in association with prevention of T lymphocyte infiltration.
Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1.
Microglial Ffar4 deficiency promotes cognitive impairment in the context of metabolic syndrome.
Dynamic behavior and lineage plasticity of the pulmonary venous endothelium.
New TIPARP inhibitor rescues mitochondrial function and brain injury in ischemic stroke.
Taohe Chengqi decoction improves diabetic cognitive dysfunction by alleviating neural stem cell senescence through HIF1α-driven metabolic signaling.
Tong-Qiao-Huo-Xue Decoction promotes synaptic remodeling via cAMP/PKA/CREB pathway in vascular dementia rats.
Osmundacetone ameliorates Alzheimer's-like pathologies by inhibiting β-amyloid fibrillation, oxidative damage and neuroinflammation in APP/PS1 transgenic mice.
Cerebral ischemic injury impairs autophagy and exacerbates cognitive impairment in APP/PS1 mice.
Optimized Proteomic Analysis of Insulin Granules From MIN6 Cells Identifies Scamp3, a Novel Regulator of Insulin Secretion and Content.
A novel derivative of evodiamine improves cognitive impairment and synaptic integrity in AD mice.
Lactobacillus-derived indole derivatives ameliorate intestinal barrier damage in rat pups with complementary food administration.
A high-fat diet induced depression-like phenotype via hypocretin-HCRTR1 mediated inflammation activation.
Psoralen protects neurons and alleviates neuroinflammation by regulating microglial M1/M2 polarization via inhibition of the Fyn-PKCδ pathway.
GDF1 ameliorates cognitive impairment induced by hearing loss.
Exercise attenuates the perioperative neurocognitive disorder induced by hyperhomocysteinemia in mice.
Butyrate reduction and HDAC4 increase underlie maternal high fructose-induced metabolic dysfunction in hippocampal astrocytes in female rats.
Huanglian Jiedu decoction alleviates neurobehavioral damage in mice with chronic alcohol exposure through the RAS-RAF-MEK-ERK pathway.
Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer's disease.
The Involvement of Progranulin for α-Synuclein Reduction through Autolysosome Formation.
Periventricular Microglia Polarization and Morphological Changes Accompany NLRP3 Inflammasome-Mediated Neuroinflammation after Hypoxic-Ischemic White Matter Damage in Premature Rats.
Dietary High-Fat Promotes Cognitive Impairment by Suppressing Mitophagy.
Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia.
A single intranasal dose of human mesenchymal stem cell-derived extracellular vesicles after traumatic brain injury eases neurogenesis decline, synapse loss, and BDNF-ERK-CREB signaling.
Dysfunction of inhibitory interneurons contributes to synaptic plasticity via GABABR-pNR2B signaling in a chronic migraine rat model.
Neuroprotective Effects of Leptin on the APP/PS1 Alzheimer's Disease Mouse Model: Role of Microglial and Neuroinflammation.
Neuroprotective effect of salidroside on hippocampal neurons in diabetic mice via PI3K/Akt/GSK-3β signaling pathway.
Chronic Kidney Disease Induces Cognitive Impairment in the Early Stage.
Clemastine fumarate attenuates tauopathy and meliorates cognition in hTau mice via autophagy enhancement.
Electroacupuncture alleviates PTSD-like behaviors by modulating hippocampal synaptic plasticity via Wnt/β-catenin signaling pathway.
CNTN1 Aggravates Neuroinflammation and Triggers Cognitive Deficits in Male Mice by Boosting Crosstalk between Microglia and Astrocytes.
The role of EndophilinA1 in chronic unpredicted mild stress-induced depression model mice.
ChemR23 activation attenuates cognitive impairment in chronic cerebral hypoperfusion by inhibiting NLRP3 inflammasome-induced neuronal pyroptosis.
The yeast prion protein Sup35 initiates α-synuclein pathology in mouse models of Parkinson's disease.
The yeast protein Ure2p triggers Tau pathology in a mouse model of tauopathy.
Inhibition of RhoA/ROCK signalling pathway activity improves neural damage and cognitive deficits in the fluorosis model.
Bone marrow mesenchymal stem cells and exercise restore motor function following spinal cord injury by activating PI3K/AKT/mTOR pathway.
Integrin β1/FAK/SRC signal pathway is involved in autism spectrum disorder in Tspan7 knockout rats.
Bilirubin Induces A1-Like Reactivity of Astrocyte.
Kynurenic acid blunts A1 astrocyte activation against neurodegeneration in HIV-associated neurocognitive disorders.
Prenatal alcohol exposure enhanced alcohol preference and susceptibility to PTSD in a sex-dependent manner through the synaptic HCN1 channel.
Polydatin Alleviates Chronic Stress-Induced Depressive and Anxiety-like Behaviors in a Mouse Model.
Magnify is a universal molecular anchoring strategy for expansion microscopy.
Exposure to bisphenol A induces neurotoxicity associated with synaptic and cytoskeletal dysfunction in neuro-2a cells.
Effect of Aging and a Dual Orexin Receptor Antagonist on Sleep Architecture and Non-REM Oscillations Including an REM Behavior Disorder Phenotype in the PS19 Mouse Model of Tauopathy.
Gut Microbiota Taxon-Dependent Transformation of Microglial M1/M2 Phenotypes Underlying Mechanisms of Spatial Learning and Memory Impairment after Chronic Methamphetamine Exposure.
Islet amyloid polypeptide triggers α-synuclein pathology in Parkinson's disease.
SIRT3 ameliorates diabetes-associated cognitive dysfunction via regulating mitochondria-associated ER membranes.
FTO-dependent m(6)A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.
Atmospheric particulate matter impairs cognition by modulating synaptic function via the nose-to-brain route.
Tunicamycin induces depression-like behaviors in male rats, accompanied by initiated chaperon-mediated autophagy and decreased synaptic protein expression in the hippocampus.
Infralimbic YTHDF1 is necessary for the beneficial effects of acute mild exercise on auditory fear extinction retention.
Copper Induces Cognitive Impairment in Mice via Modulation of Cuproptosis and CREB Signaling.
Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage.
Ginsenoside Rb1 protects hippocampal neurons in depressed rats based on mitophagy-regulated astrocytic pyroptosis.
Extracellular vesicles from hiPSC-NSCs can prevent peripheral inflammation-induced cognitive dysfunction with inflammasome inhibition and improved neurogenesis in the hippocampus.
Gypenoside IX restores Akt/GSK-3β pathway and alleviates Alzheimer's disease-like neuropathology and cognitive deficits.
Homocysteine impedes neurite outgrowth recovery after intracerebral haemorrhage by downregulating pCAMK2A.
Sirt1 Overexpression Inhibits Fibrous Scar Formation and Improves Functional Recovery After Cerebral Ischemic Injury Through the Deacetylation of 14-3-3ζ.
CNTN1 in the Nucleus Accumbens is Involved in Methamphetamine-Induced Conditioned Place Preference in Mice.
The microglial innate immune receptors TREM-1 and TREM-2 in the anterior cingulate cortex (ACC) drive visceral hypersensitivity and depressive-like behaviors following DSS-induced colitis.
The effects of acupuncture on depression by regulating BDNF-related balance via lateral habenular nucleus BDNF/TrkB/CREB signaling pathway in rats.
Aerobic Exercise Facilitates the Nuclear Translocation of SREBP2 by Activating AKT/SEC24D to Contribute Cholesterol Homeostasis for Improving Cognition in APP/PS1 Mice.
A terrified-sound stress causes cognitive impairment in female mice by impairing neuronal plasticity.
Corticostriatal Projections Relying on GABA Levels Mediate Exercise-Induced Functional Recovery in Cerebral Ischemic Mice.
Thymol improves autism-like behaviour in VPA-induced ASD rats through the Pin1/p38 MAPK pathway.
miR-6315 silencing protects against spinal cord injury through the Smo and anti-ferroptosis pathway.
Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix.
The role of reactive astrocytes in neurotoxicity induced by ultrafine particulate matter.
Peripheral Transplantation of Mesenchymal Stem Cells at Sepsis Convalescence Improves Cognitive Function of Sepsis Surviving Mice.
Treatment Combining Focused Ultrasound with Gastrodin Alleviates Memory Deficit and Neuropathology in an Alzheimer's Disease-Like Experimental Mouse Model.
Protective effect of microorganism biotransformation-produced resveratrol on the high fat diet-induced hyperlipidemia, hepatic steatosis and synaptic impairment in hamsters.
Young plasma reverses anesthesia and surgery-induced cognitive impairment in aged rats by modulating hippocampal synaptic plasticity.
Confinement induces oxidative damage and synaptic dysfunction in mice.
Hippocampal Iron Accumulation Impairs Synapses and Memory via Suppressing Furin Expression and Downregulating BDNF Maturation.
RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission.
Combined cell grafting and VPA administration facilitates neural repair through axonal regeneration and synaptogenesis in traumatic brain injury.
Profile of chimeric RNAs and TMPRSS2-ERG e2e4 isoform in neuroendocrine prostate cancer.
Evaluation of Neurotoxicity in BALB/c Mice following Chronic Exposure to Polystyrene Microplastics.
Chrysin alleviates lipopolysaccharide-induced neuron damage and behavioral deficits in mice through inhibition of Fyn.
Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like mice.
Dietary Salt Disrupts Tricarboxylic Acid Cycle and Induces Tau Hyperphosphorylation and Synapse Dysfunction during Aging.
Fast resupply of synaptic vesicles requires synaptotagmin-3.
Differential Expression of Secretogranins II and III in Canine Adrenal Chromaffin Cells and Pheochromocytomas.
A synapsin Ⅰ cleavage fragment contributes to synaptic dysfunction in Alzheimer's disease.
m6A and YTHDF proteins contribute to the localization of select neuronal mRNAs.
Exercise-induced neuroprotection against cerebral ischemia/reperfusion injury is mediated via alleviating inflammasome-induced pyroptosis.
Progranulin improves neural development via the PI3K/Akt/GSK-3β pathway in the cerebellum of a VPA-induced rat model of ASD.
Heatstroke-induced late-onset neurological deficits in mice caused by white matter demyelination, Purkinje cell degeneration, and synaptic impairment in the cerebellum.
Proteomic analysis of the effects of caffeine in a neonatal rat model of hypoxic-ischemic white matter damage.
Transient neuroinflammation following surgery contributes to long-lasting cognitive decline in elderly rats via dysfunction of synaptic NMDA receptor.
Gestational exposure to fluoride impairs cognition in C57 BL/6 J male offspring mice via the p-Creb1-BDNF-TrkB signaling pathway.
DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors.
The circRNA circ-Nbea participates in regulating diabetic encephalopathy.
Liraglutide Alleviates Cognitive Deficit in db/db Mice: Involvement in Oxidative Stress, Iron Overload, and Ferroptosis.
Polygonatum sibiricum ameliorated cognitive impairment of naturally aging rats through BDNF-TrkB signaling pathway.
Effects of neuron autophagy induced by arsenic and fluoride on spatial learning and memory in offspring rats.
Heat shock protein Hspa13 regulates endoplasmic reticulum and cytosolic proteostasis through modulation of protein translocation.
Inhibition of BRD4 decreases fibrous scarring after ischemic stroke in rats by inhibiting the phosphorylation of Smad2/3.
FOXO3 Regulates Sevoflurane-Induced Neural Stem Cell Differentiation in Fetal Rats.
Acute lead acetate induces neurotoxicity through decreased synaptic plasticity-related protein expression and disordered dendritic formation in nerve cells.
Identification of distinct genomic features reveals frequent somatic AHNAK and PTEN mutations predominantly in primary malignant melanoma presenting in the ureter.
Traumatic Brain Injury Accelerates the Onset of Cognitive Dysfunction and Aggravates Alzheimer's-Like Pathology in the Hippocampus by Altering the Phenotype of Microglia in the APP/PS1 Mouse Model.
Nicotinamide Improves Cognitive Function in Mice With Chronic Cerebral Hypoperfusion.
Postconditioning with Sevoflurane or Propofol Alleviates Lipopolysaccharide-Induced Neuroinflammation but Exerts Dissimilar Effects on the NR2B Subunit and Cognition.
Abnormal spatiotemporal expression pattern of progranulin and neurodevelopment impairment in VPA-induced ASD rat model.
YAP drives fate conversion and chemoresistance of small cell lung cancer.
Neuroprotective effects of macamide from maca (Lepidium meyenii Walp.) on corticosterone-induced hippocampal impairments through its anti-inflammatory, neurotrophic, and synaptic protection properties.
Iptakalim alleviates synaptic damages via targeting mitochondrial ATP-sensitive potassium channel in depression.
Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.
Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease.
Caloric restriction ameliorates high-fat diet induced cognitive deficits through attenuating neuroinflammation via the TREM2-PI3K/AKT signaling pathway.
Histone demethylase PHF8 drives neuroendocrine prostate cancer progression by epigenetically upregulating FOXA2.
Hippocampal LASP1 ameliorates chronic stress-mediated behavioral responses in a mouse model of unpredictable chronic mild stress.
Enriched environment remedies cognitive dysfunctions and synaptic plasticity through NMDAR-Ca(2+)-Activin A circuit in chronic cerebral hypoperfusion rats.
Haploinsufficiency of the TDP43 ubiquitin E3 ligase RNF220 leads to ALS-like motor neuron defects in the mouse.
Quantitative proteomic analysis of cortex in the depressive-like behavior of rats induced by the simulated complex space environment.
Curcumin Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors via Restoring Changes in Oxidative Stress and the Activation of Nrf2 Signaling Pathway in Rats.
Xiaoyao Pills Attenuate Inflammation and Nerve Injury Induced by Lipopolysaccharide in Hippocampal Neurons In Vitro.
Transplantation of Stem Cells from Human Exfoliated Deciduous Teeth Decreases Cognitive Impairment from Chronic Cerebral Ischemia by Reducing Neuronal Apoptosis in Rats.
Bisphenol-A exposure induced neurotoxicity and associated with synapse and cytoskeleton in Neuro-2a cells.
Identification and immunohistochemical characterization of G-quadruplexes in mouse brain.
Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice.
The Neurotrophic Function of Glucagon-Like Peptide-1 Promotes Human Neuroblastoma Differentiation via the PI3K-AKT Axis.
Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells.
The critical role of the hippocampal NLRP3 inflammasome in social isolation-induced cognitive impairment in male mice.
NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.
Small dose of L-dopa/Benserazide hydrochloride improved sepsis-induced neuroinflammation and long-term cognitive dysfunction in sepsis mice.
Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia.
Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer's Disease Pathogenesis in Cell and Animal Models.
Fingolimod (FTY720) improves postoperative cognitive dysfunction in mice subjected to D-galactose-induced aging.
Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2.
Cancer cell's neuroendocrine feature can be acquired through cell-cell fusion during cancer-neural stem cell interaction.
Cryopreservation of a Human Brain and Its Experimental Correlate in Rats.
Corticosterone Induced the Increase of proBDNF in Primary Hippocampal Neurons Via Endoplasmic Reticulum Stress.
Subcutaneous administration of β-hydroxybutyrate improves learning and memory of sepsis surviving mice.
Xiaoyao Pills Prevent Lipopolysaccharide-Induced Depression by Inhibiting Inflammation and Protecting Nerves.
MicroRNA-99a is a Potential Target for Regulating Hypothalamic Synaptic Plasticity in the Peri/Postmenopausal Depression Model.
Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer's disease.
Neuroprotective effects of a Smoothened receptor agonist against postoperative cognitive dysfunction by promoting autophagy in the dentate gyrus of aged rats.
Cinnamic acid rescues behavioral deficits in a mouse model of traumatic brain injury by targeting miR-455-3p/HDAC2.
SMCR8 negatively regulates AKT and MTORC1 signaling to modulate lysosome biogenesis and tissue homeostasis.
Absence of BBSome function leads to astrocyte reactivity in the brain.
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE.
Chronic fluoride exposure induces neuronal apoptosis and impairs neurogenesis and synaptic plasticity: Role of GSK-3β/β-catenin pathway.
PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by influencing synaptic function in the primary motor cortex of rats.
A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets.
Cadmium induces actin cytoskeleton alterations and dysfunction in Neuro-2a cells.
Brain-Derived Neurotrophic Factor Precursor in the Hippocampus Regulates Both Depressive and Anxiety-Like Behaviors in Rats.
Mesenchymal Stem Cell-Derived Exosomes Reduce A1 Astrocytes via Downregulation of Phosphorylated NFκB P65 Subunit in Spinal Cord Injury.
Metformin Inhibits Prostate Cancer Progression by Targeting Tumor-Associated Inflammatory Infiltration.
Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury.
Rodent Neural Progenitor Cells Support Functional Recovery after Cervical Spinal Cord Contusion.
Pin1 mediates Aβ(42)-induced dendritic spine loss.
Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease.
Quantitative proteomics study of host response to virulent and attenuated pseudorabies virus infection in mouse brain.
Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury.
Pre-existing weakness is critical for the occurrence of postoperative cognitive dysfunction in mice of the same age.
Sepsis-induced selective loss of NMDA receptors modulates hippocampal neuropathology in surviving septic mice.
Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models.
Aqua-soluble DDQ reduces the levels of Drp1 and Aβ and inhibits abnormal interactions between Aβ and Drp1 and protects Alzheimer's disease neurons from Aβ- and Drp1-induced mitochondrial and synaptic toxicities.
The effects of fluoride on neuronal function occurs via cytoskeleton damage and decreased signal transmission.
Chronic administration of parecoxib exerts anxiolytic-like and memory enhancing effects and modulates synaptophysin expression in mice.
Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters.
Identification of TMEM230 mutations in familial Parkinson's disease.
Identification of protein network alterations upon retinal ischemia-reperfusion injury by quantitative proteomics using a Rattus norvegicus model.
Effect of treadmill exercise on 5-HT, 5-HT1A receptor and brain derived neurophic factor in rats after permanent middle cerebral artery occlusion.
Gao F, Yang X, Yang Z, Yu D, Zhang B, Wang Y, Yao Z, Chen J, Liao Q, Li L, Hou B, Wang D, Zhang Y, Yan C
Research (Washington, D.C.) 2026;9:1032
Research (Washington, D.C.) 2026;9:1032
GSTA1 deficiency drives neuroendocrine differentiation via TNFRSF13B/c-FOS/CHGA axis in prostate cancer.
Qian J, Luo Y, Fu Y, Diao W, Ding Q, Chen W, Qiu X, Guo H
International journal of biological sciences 2026;22(3):1632-1647
International journal of biological sciences 2026;22(3):1632-1647
Astrocytic GSTM2-STAT3 interaction ameliorates the diabetes associated cognitive dysfunction via targeting mitochondrial defects and oxidative stress.
Liu W, Wang Y, Zhao Y, Song B, Luo L, Zahir KM, Song M, Wang Y, Zhang L, Zuo Z, Yao L
Redox biology 2026 May;92:104137
Redox biology 2026 May;92:104137
Tumor Prostate-Specific Antigen Density Can Predict Tumor Aggressiveness and Heterogeneity in Prostate Cancer.
Yang T, Wang X, Deng Y, Liu H, Chen Y, Zhao J, Huang Y, Liu S, Cao M, Zhang Q, Wang X, Xu H, Wu D, Zhuo H
The Prostate 2026 May;86(7):821-830
The Prostate 2026 May;86(7):821-830
Age-dependent elevation of Nr4a1 attenuates PI3K/AKT/GSK3β pathway and mediates tau hyperphosphorylation and cognitive impairments.
Lei L, Guo Q, Cheng Y, Gui Y, Li W, Zhao Y, Xu Z, Luo Y, Wu G, Wang JZ, Liu R, Li HL, Wang X
Journal of advanced research 2026 Mar;81:393-408
Journal of advanced research 2026 Mar;81:393-408
Clemastine ameliorates cognitive deficits in an experimental rat model of chronic cerebral hypoperfusion.
Zong X, Huang Z, Kong F, Feng Y, Zhang Y, Zou P, Wen Lin H, Hess DC, Zhang Q
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2026 Mar;46(3):786-803
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2026 Mar;46(3):786-803
Insulin-like growth factor 2 alleviates metabolic inflammation and associated cognitive impairment in diet-induced obesity mice.
Liu X, Chen L, Chen Y, Huang Y, Xiao X, Zhong X
Diabetes, obesity & metabolism 2026 Mar;28(3):1800-1816
Diabetes, obesity & metabolism 2026 Mar;28(3):1800-1816
De-2-hydroxyisobutyrylation of clusterin modulates neuropathology and memory deficits in an Alzheimer's disease mouse model.
Peng X, Ouyang C, Ma F, Liu Y, Luo L, Xing J, Feng S, Li L, Zhang J, Wang J, Cheng H, Zhang T, Chen F, Wang Y, Cui L
Cell communication and signaling : CCS 2026 Mar 9;24(1)
Cell communication and signaling : CCS 2026 Mar 9;24(1)
BMSC exosomes promote neurogenesis and alleviate behavioral deficits in chronic traumatic encephalopathy: an animal model-based study.
Liu P, Bai Z, Yang Y, Li X, Xia J, Yang Q
Stem cell research & therapy 2026 Mar 5;17(1)
Stem cell research & therapy 2026 Mar 5;17(1)
Discovery of Novel Pyrano[3,2-a]carbazole Alkaloid Derivatives against Ischemic Stroke by Targeting ADGRL3.
Tao A, Lin Y, Feng J, Luo H, Qu K, Kang Y, Yu H, Chuangjun L, Ma J, Huang W, Sheng L, Zhang D, Zang Y, Peng Y
Journal of medicinal chemistry 2026 Mar 26;69(6):7012-7031
Journal of medicinal chemistry 2026 Mar 26;69(6):7012-7031
SMARCA4 promotes lineage plasticity and enzalutamide resistance in prostate cancer by regulating PROX1 via H3K27 acetylation.
Wu C, Luo M, Wu C, Yuan Y, Li Y, Liao Y, Zhang Y, Huang X, Wang M, Lv S, Wei Q
Cell death discovery 2026 Mar 25;12(1)
Cell death discovery 2026 Mar 25;12(1)
Modeling spastic paraplegia 4 with corticospinal motor neuron-enriched cortical organoids reveals genotype-phenotype and HDAC6-targetable pathology.
Mohan N, Ramakrishnan S, Sun X, Sun Y, Connors T, Chai V, Piermarini E, Baas PW, Cai J, Liu M, Qiang L
Cell reports 2026 Mar 24;45(3):117036
Cell reports 2026 Mar 24;45(3):117036
Copper depletion ameliorates neuronal damage after intracerebral hemorrhage.
Zhang W, Wu G, Wang L, Ren S
Neurochemistry international 2026 Jun;196:106150
Neurochemistry international 2026 Jun;196:106150
Abnormal FKN-CX3CR1-NR signal triggers hippocampal synaptic dysfunction in rheumatoid arthritis-related depression.
Yao SX, Luo SY, Zhao HQ, Tan H, Liu PA, Liu J
International immunopharmacology 2026 Jul 15;181:116693
International immunopharmacology 2026 Jul 15;181:116693
Methyl 3-chloroasterric acid exerted anti-neuroinflammatory and antidepressant effects through the downregulation of P2Y1R.
Zhang Y, Sun M, Zhang Z, Jia Y, Xiao H, Xu X, Pan X, Li Z
International immunopharmacology 2026 Jul 15;181:116689
International immunopharmacology 2026 Jul 15;181:116689
Astrocyte-Specific Nrf2 Expression Transforms Neurotoxic Reactive Astrocytes to Neuroprotective Phenotype in 3xTg-AD Mice.
Guo S, Wei F, Sun H, Jin H, Cheng W, Fu C, Wang H, Yin Y
Glia 2026 Jan;74(1):e70087
Glia 2026 Jan;74(1):e70087
Buyang Huanwu decoction facilitates the repair of red nucleus neurons subsequent to spinal cord injury in rats via autophagy.
Deng J, Zhang Y, Xie W, Li L, Li Q
The journal of spinal cord medicine 2026 Jan;49(1):95-106
The journal of spinal cord medicine 2026 Jan;49(1):95-106
Tuina Inhibits Synaptic Plasticity Through the Astrocytic NDRG2/GLT-1 Pathway to Alleviate Neuropathic Pain.
Zhang H, Chen L, Jiang J, Huang L, Huang H, Huang L, Chen S, Lin Z
Journal of cellular and molecular medicine 2026 Jan;30(1):e71013
Journal of cellular and molecular medicine 2026 Jan;30(1):e71013
BST2 expression at astrocyte borders promotes microglial recruitment via the C3/C3aR signaling.
Zhang S, Yuan M, Zhou J, Zhao Y, Wang L, Gong C, Lu H, Cheng X, Wang X, He Q, Hu L, Wang B, He C, Fang Y, Lin S, Zi W, He Y, Zhao C, Zheng H, Niu J, Mei F, Sun B, Xie Q, Yang Q
Neuron 2026 Jan 7;114(1):67-85.e8
Neuron 2026 Jan 7;114(1):67-85.e8
Hydrogel with cell-cell adhesion cues enhances neural regeneration.
Tang X, Zhang S, Liu M, Liang Y, Fan Y, Sun X, He C, Yang X, Zhu R, Jin X, Zhuang Q, Ge Y, Ling J, Yang Y
Nature communications 2026 Jan 19;17(1)
Nature communications 2026 Jan 19;17(1)
Fibrinogen drives neuroinflammation and neuropathology in perioperative neurocognitive disorders.
Wang X, Jiang S, Di L, Li S, Chen H, Huang P, Cao T, Jin W, Huang L
International immunopharmacology 2026 Jan 1;168(Pt 2):115906
International immunopharmacology 2026 Jan 1;168(Pt 2):115906
Hydrogen-Mediated Activation of the Nrf2/HO-1 Signaling Pathway Improves Cognitive Impairment in Sleep-Deprived Mice.
Xiao Q, Zhou S, Tang B, Zhu Y
CNS neuroscience & therapeutics 2026 Feb;32(2):e70770
CNS neuroscience & therapeutics 2026 Feb;32(2):e70770
IL-17A-mediated copper accumulation participates in chronic neuropathic pain-induced cognitive impairment by enhancing microglial synaptic pruning.
Liu J, Li Z, Peng X, Zhao W, Chu T, Ju J, Ren J, Gao F
Brain, behavior, and immunity 2026 Feb;132:106208
Brain, behavior, and immunity 2026 Feb;132:106208
Long-Term Effects of Xenotransplantation of Human Enteric Glia in an Immunocompetent Rat Model of Acute Brain Injury.
Colitti N, Rice E, Desmoulin F, Combeau M, Parny M, Robert L, Buscail E, Bournet B, Vergnolle N, Raymond-Letron I, Loubinoux I, Cirillo C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(12):e03362
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(12):e03362
UHRF1 regulates AR ubiquitination to promote the loss of AR signaling and enzalutamide resistance in progression of prostate cancer.
Zhang Y, Yu Z, Li Y, Luo M, Hou W, Li S, He J, Lv S, Wei Q, Hu H
Cell death & disease 2026 Feb 27;17(1)
Cell death & disease 2026 Feb 27;17(1)
Simulated microgravity affects neuronal synaptic plasticity by regulating microglial pro-inflammatory activation.
Chen X, Yuan C, Li Z, Zhao T, Yang Y, Wang Y, Qiao C, Liu Z, Li X
NPJ microgravity 2026 Feb 26;12(1)
NPJ microgravity 2026 Feb 26;12(1)
Effects of Short-Term Exposure to Polystyrene Nanoplastics on the Nervous System: Calcium Homeostasis, BDNF and Synaptic Plasticity.
Zhao Y, Yan L, Wei Y, Ma J, Chen J, Liu X, Mi Y, Wang B, Zhang L, Tian L, Lin B
Toxics 2026 Feb 17;14(2)
Toxics 2026 Feb 17;14(2)
Circadian Rhythm Disorder-Related Dysfunctions are Exacerbated by Aging and Ameliorated by Time-Restricted Feeding.
Huo F, Liu Q, Zhang S, Liu X, Lv S, Zhao M, Liu Y, Zhu X, Huang C, Feng S, Wang H, Xu S, Shen J, Gao J, Su T, Wu Y, Jiang R, Zhu JK, Liu H
Neuroscience bulletin 2026 Apr;42(4):872-896
Neuroscience bulletin 2026 Apr;42(4):872-896
UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration.
Liu Y, Huang Z, Hsu YW, Deme P, Frankenfield AM, Wu S, Zhao X, Liu H, Zhang T, Alexander EJ, Liu M, Zhang Y, Wang H, Zhou Y, Monteiro MJ, Hao L, Haughey NJ, Wang J
Nature neuroscience 2026 Apr;29(4):782-795
Nature neuroscience 2026 Apr;29(4):782-795
Design, synthesis, and investigation of anti-Alzheimer's activity and molecular mechanisms of phosphatidylserine derivatives.
Lin Y, Lin X, Zhu J, Li M, Xi Y, Lu D, Zhang Y, Fu L, Jiang F
European journal of medicinal chemistry 2026 Apr 5;307:118676
European journal of medicinal chemistry 2026 Apr 5;307:118676
Gut microbial metabolite indole-3-acetic acid inhibits microglia-mediated synaptic loss in Alzheimer's disease by targeting CCR4.
Ye T, Lv X, Li Q, Liao X, Zhan L, Dai C, Xiang K, Lin X, Sun J, Liu J
Brain, behavior, and immunity 2026 Apr 19;136:106769
Brain, behavior, and immunity 2026 Apr 19;136:106769
Probiotic supplementation attenuated early-life chemotherapy-induced brain development impairment in mice.
Tan A, Chen J, Zhang J, Tong J, Jiang Z
Frontiers in behavioral neuroscience 2025;19:1697727
Frontiers in behavioral neuroscience 2025;19:1697727
Research on the correlation between gut microbiota and brain cognitive function under chronic hypoxia at high altitude.
Zeng F, Li H, Ma Y, Ma S
Frontiers in neuroscience 2025;19:1600069
Frontiers in neuroscience 2025;19:1600069
Photochemically induced thrombosis combined with chronic restraint stress for modeling post-stroke depression in mice.
Tuersunjiang T, Wang Q, Wang Z, Gao F, Wang Z
Frontiers in neuroscience 2025;19:1547551
Frontiers in neuroscience 2025;19:1547551
Distinct neuroprotective and anti-inflammatory effects of Kampo formulas ninjinyoeito and juzentaihoto in depression-like SAMP8 mice.
Maruko A, Ito N, Oshima K, Nishi A, Kobayashi Y, Okada N
Frontiers in pharmacology 2025;16:1600176
Frontiers in pharmacology 2025;16:1600176
N-acetyltransferase 10 in the nucleus accumbens participates in methamphetamine-induced conditioned place preference and hyperlocomotion in mice.
Zeng ZH, Zhang LX, Li MQ, Wang XQ, Zou GJ, Yao JY, Li CQ, Cui YH, Li F
Neurochemistry international 2025 Sep;188:106017
Neurochemistry international 2025 Sep;188:106017
Role of Netrin-1 dysregulation in early neuronal pathology of α-synuclein models of Parkinson's disease.
Han W, Wang T, Tan N, Liu H, He P, Hua Y, Fan Y
Journal of advanced research 2025 Sep 4;
Journal of advanced research 2025 Sep 4;
Umbelliferone Alleviates Sleep Deprivation Induced Cognitive Impairment through the Modulation of Gut Microbiota.
Jiang Y, Ni Z, Dai H, Luo X, Xing J, Wang R, Zhang X
Journal of agricultural and food chemistry 2025 Sep 24;73(38):24155-24168
Journal of agricultural and food chemistry 2025 Sep 24;73(38):24155-24168
The niacin receptor HCAR2 prevents sleep deprivation-induced cognitive impairment by inhibiting microglia-mediated neuroinflammation in mice.
Cheng Z, Qian T, Yu J, Yan Y, Jing L, Yang B, Tang H, Yan A, Liu M, Song Y, Dai J
International immunopharmacology 2025 Sep 23;162:115174
International immunopharmacology 2025 Sep 23;162:115174
The role of REST in regulating the BDNF/TrkB signalling pathway in nano-alumina induced cognitive dysfunction in zebrafish.
Zhang J, Wang S, Jin Z, Ma L, Wang Y, Zhang H, Nie J, Niu Q
Ecotoxicology and environmental safety 2025 Sep 15;303:118998
Ecotoxicology and environmental safety 2025 Sep 15;303:118998
Cognitive impairment induced by psychological stress is time-of-day of exposure dependent in female rats.
Wang X, Gao S, Chen L, Zhang L, Liu X, Yin C, Xiao X, Xiong X, Yang J
Brain research 2025 Sep 15;1863:149837
Brain research 2025 Sep 15;1863:149837
Lactobacillus acidophilus promotes cognitive function recovery via regulating microglial peroxisomal function in cerebral ischemia.
Huang Y, Zhang X, Yu C, Liu Y, Kang H, Liu Y, Ni Y, Xia Y, Jiang Z, Chen J, Zhao K, Han L, Zou X, Wang J, Lei T, Gan C, Zhang H
Cell host & microbe 2025 Sep 10;33(9):1484-1501.e12
Cell host & microbe 2025 Sep 10;33(9):1484-1501.e12
Huang Lian Jie Du Decoction Prevents Chronic Alcoholic Encephalopathy and Improves Gut Microbiota Imbalance in Mice.
Chen Y, Jiang L, Zhang Y, Shen Y, Li M, Yang D, Wang B
Molecular neurobiology 2025 Oct;62(10):13665-13677
Molecular neurobiology 2025 Oct;62(10):13665-13677
SFRS8 Regulates Memory by Modulating RNA Splicing of Synaptic Genes.
Ding Z, Liu Q, Zhang J
Molecular neurobiology 2025 Oct;62(10):12523-12538
Molecular neurobiology 2025 Oct;62(10):12523-12538
Design of the Hydrophobic Core of Self-Assembling Peptide Fibrils for Enhanced Neural Regeneration.
Tsai YL, Cavallo P, Lu Q, Yu J, Ender CP, Link J, Amann-Winkel K, Endres K, Synatschke CV, John T
Small science 2025 Oct;5(10):2500224
Small science 2025 Oct;5(10):2500224
USP47 Regulates Excitatory Synaptic Plasticity and Modulates Seizures in Murine Models by Blocking Ubiquitinated AMPAR Degradation.
Yang J, Zhang H, Wang Y, Luo Y, Zheng W, Liu Y, Jiang Q, Deng J, Liu Q, Zhang P, Huang H, Yu C, Xu Z, Chen Y
Neuroscience bulletin 2025 Oct;41(10):1805-1823
Neuroscience bulletin 2025 Oct;41(10):1805-1823
Molecular and immune characteristics of neuroendocrine bladder carcinoma - Implications for diagnosis, prognosis, and therapy: A review.
Zhang T, Zhang X, Qian L, Hu C, Li J
Biomolecules & biomedicine 2025 Oct 9;26(5):711-719
Biomolecules & biomedicine 2025 Oct 9;26(5):711-719
Air pollution decreases postsynaptic PSD-95 and NMDA receptor subunits in synaptosomes from mouse cerebral cortex.
Godoy-Lugo JA, Hicks D, Durra S, Massey ER, Shkirkova K, Sauri AI, Kerstiens E, Chen S, Zhao L, Sioutas C, Mack WJ, Finch CE, Thorwald MA
Environmental pollution (Barking, Essex : 1987) 2025 Oct 15;383:126845
Environmental pollution (Barking, Essex : 1987) 2025 Oct 15;383:126845
Enriched environment ameliorates neurobehavioral abnormalities, hippocampal inflammation, and synaptic dysfunction in adult male mice exposed to intermittent hypoxia during pregnancy.
Fang SK, Hu F, Zhang Y, Lun WZ, Zhang YM, Li XY, Zhang KX, Hu ZY, Wei RM, Ren CY, Chen GH
Brain research bulletin 2025 Oct 15;231:111544
Brain research bulletin 2025 Oct 15;231:111544
Single-cell RNA-seq reveals cell type-specific molecular and genetic associations with primary open-angle glaucoma.
Tian H, Chen Y, Zhao T, Ye L, Li H, Li Z, Qiu W, Wang W, Li R, Liu F, Xue H, Liao R, Qu C, Li J, Zou L, Shi Y, Yang Z, Huang L
Signal transduction and targeted therapy 2025 Oct 10;10(1):338
Signal transduction and targeted therapy 2025 Oct 10;10(1):338
Blood flow restriction training attenuates stroke-induced hippocampal ferroptosis, synaptic damage, and cognitive impairment via upregulating SIRT1 pathway.
Zhou F, Zhu X, Zhang X, Lin C, Ma Y, Lin Q, Li X
Neuroscience 2025 Oct 1;584:295-310
Neuroscience 2025 Oct 1;584:295-310
Urolithin A improves Parkinson's disease-associated cognitive impairment through modulation of neuroinflammation and neuroplasticity.
Xu N, Du C, Yu Y, Li Y, Gao S, Yu S, Sun B, Lou H
Experimental neurology 2025 Nov;393:115395
Experimental neurology 2025 Nov;393:115395
Xanthouhumol relieves stress-induced depressive-like behaviors through the Sirt1/NF-κB/NLRP3 pathway.
Lin G, Zhang Y, Qin J, He Y, Fan L, Tan Q, Xie P
Psychopharmacology 2025 Nov;242(11):2579-2590
Psychopharmacology 2025 Nov;242(11):2579-2590
Inhibition of spreading depolarizations by targeting GABA(A) receptors and voltage-gated sodium channels improves neurological deficits in rats with traumatic brain injury.
Yan R, Liu Q, Zhang D, Li K, Li Y, Nie Y, Zhang Y, Li P, Mao S, Li H
British journal of pharmacology 2025 Nov;182(21):5247-5268
British journal of pharmacology 2025 Nov;182(21):5247-5268
High glucose induces hippocampal neuron impairment through the SKP1/COX7C pathway: A potential mechanism for perimenopausal depression.
Wang Z, Liu Z, Feng S, Song X, Liu D, Ma N, Zhang X, Liu W, Wang DO, Liu X, Ikejima T
Acta pharmaceutica Sinica. B 2025 Nov;15(11):5832-5853
Acta pharmaceutica Sinica. B 2025 Nov;15(11):5832-5853
Chronic ethanol exposure induces hippocampal neuroinflammation and neuronal damage via the astrocytic RUNX1/TOLLIP/TLR3 pathway.
Shen H, Zhang Q, Lv Q, Liu H, Wang C, Meng F, Guo Y, Pei J, Yu C, Tie J, Chen X, Zhang C, Yu H, Wang X
Brain, behavior, and immunity 2025 Nov;130:106081
Brain, behavior, and immunity 2025 Nov;130:106081
Nicotine Improves Memory Impairment in Aged Rats Through Enhanced Mitochondrial Homeostasis.
Ni Z, Li Y, Wang G, Wang S, Chen H, Hou H, Hu Q
Molecular neurobiology 2025 Nov 14;63(1):38
Molecular neurobiology 2025 Nov 14;63(1):38
Peptide Photoimmobilization by Thiol-ene Chemistry for Enhanced Neural Cell Adhesion.
Tsai YL, Moschopoulou-Triantafyllidou S, Yu J, Albarqawi S, Marchesi D'Alvise T, Veith L, Berger R, Synatschke CV
ACS biomaterials science & engineering 2025 Nov 10;11(11):6844-6853
ACS biomaterials science & engineering 2025 Nov 10;11(11):6844-6853
FGF21 Exhibits Neuroprotective Effects by Promoting 5-HT(1A)R-FGFR1 Heteroreceptor Complexes and Triggering MEK(1/2)-ERK(1/2) Signaling Pathway.
Yan Q, Li XJ, Wang QQ, Jia W, Wang SL
Molecular neurobiology 2025 May;62(5):6369-6382
Molecular neurobiology 2025 May;62(5):6369-6382
Nose-to-Brain Delivery of Circular RNA SCMH1-Loaded Lipid Nanoparticles for Ischemic Stroke Therapy.
Jia Y, Xu L, Leng S, Sun Y, Huang X, Wang Y, Ren H, Li G, Bai Y, Zhang Z, Han B, Shen L, Ju M, Chen L, Yao H
Advanced materials (Deerfield Beach, Fla.) 2025 May;37(19):e2500598
Advanced materials (Deerfield Beach, Fla.) 2025 May;37(19):e2500598
Aerobic exercise improves astrocyte mitochondrial quality and transfer to neurons in a mouse model of Alzheimer's disease.
Cai J, Chen Y, She Y, He X, Feng H, Sun H, Yin M, Gao J, Sheng C, Li Q, Xiao M
Brain pathology (Zurich, Switzerland) 2025 May;35(3):e13316
Brain pathology (Zurich, Switzerland) 2025 May;35(3):e13316
Misdiagnosis of esophageal leiomyoma combined with adrenal cortical adenoma as esophageal cancer with adrenal metastasis by fluorine-18-fluorodeoxyglucose positron emission tomography: A case report.
Sun X, Lv L, Fan D, Huang Y, Zhu L, Liu H
Oncology letters 2025 May;29(5):238
Oncology letters 2025 May;29(5):238
Distinct In Vitro Differentiation Protocols Differentially Affect Cytotoxicity Induced by Heavy Metals in Human Neuroblastoma SH-SY5Y Cells.
Ferdous J, Naitou K, Shiraishi M
Biological trace element research 2025 May;203(5):2595-2605
Biological trace element research 2025 May;203(5):2595-2605
Co-exposure to ozone and polystyrene nanoplastic exacerbates cognitive impairment and anxiety-like behavior by regulating neuronal pyroptosis in mice.
Dai A, Liu X, Chen Y, Wang Y, Qi H, Zeng Y, Li J
Environment international 2025 May;199:109501
Environment international 2025 May;199:109501
MiR-29a-3p ameliorate behavioral deficiency in hypoxia-ischemia brain damage in neonatal mice by inhibiting BTG2.
Luo Q, Xing X, Song Y, Gu B, Hu Q, Liu W, Xiao Y, Wang Z
Behavioural brain research 2025 May 28;486:115552
Behavioural brain research 2025 May 28;486:115552
Astrocyte-derived CCL5-mediated CCR5(+) neutrophil infiltration drives depression pathogenesis.
Yao H, Jiang SY, Jiao YY, Zhou ZY, Zhu Z, Wang C, Zhang KZ, Ma TF, Hu G, Du RH, Lu M
Science advances 2025 May 23;11(21):eadt6632
Science advances 2025 May 23;11(21):eadt6632
Basal-shift transformation leads to EGFR therapy-resistance in human lung adenocarcinoma.
Shinozaki T, Togasaki K, Hamamoto J, Mitsuishi A, Fukushima T, Sugihara K, Ebisudani T, Okada M, Saito A, Shigematsu L, Takaoka H, Ito F, Ohgino K, Ishioka K, Watanabe K, Hishima T, Kurebayashi Y, Emoto K, Terai H, Ikemura S, Kawada I, Asakura K, Hishida T, Asamura H, Ohta Y, Takahashi S, Oda M, Saito M, Matano M, Soejima K, Fujii M, Fukunaga K, Yasuda H, Sato T
Nature communications 2025 May 11;16(1):4369
Nature communications 2025 May 11;16(1):4369
Exercise-induced Activation of SIRT1/BDNF/mTORC1 Signaling Pathway: A Novel Mechanism to Reduce Neuroinflammation and Improve Post-stroke Depression.
Tang J, Lu L, Yuan J, Feng L
Actas espanolas de psiquiatria 2025 Mar;53(2):366-378
Actas espanolas de psiquiatria 2025 Mar;53(2):366-378
Melatonin Alleviates Behavioral and Neurodevelopmental Abnormalities in Offspring Caused by Prenatal Stress.
Wu D, Du J, Zhao T, Li N, Qiao X, Peng F, Wang D, Shi J, Zhang S, Diao C, Wang L, Zhou W, Hao A
CNS neuroscience & therapeutics 2025 Mar;31(3):e70347
CNS neuroscience & therapeutics 2025 Mar;31(3):e70347
Sequential Proteomic Analysis Reveals the Key APOE4-Induced Pathological and Molecular Features at the Presymptomatic Stage in Alzheimer's Disease Mice.
Wei P, Lin K, Chen X, Fang C, Qiu L, Hu J, Chang J
CNS neuroscience & therapeutics 2025 Mar;31(3):e70306
CNS neuroscience & therapeutics 2025 Mar;31(3):e70306
Exosome-Derived CDC42 From Hypoxia-Pretreated Neural Stem Cells Inhibits ACSL4-Related Ferroptosis to Alleviate Vascular Injury in Parkinson's Disease Mice Models.
Li Y, Jiang J, Li J, Liu S, Wang C, Yu Z, Xia Y
Journal of neurochemistry 2025 Mar;169(3):e70027
Journal of neurochemistry 2025 Mar;169(3):e70027
Correlative light and electron microscopy imaging of proteinaceous deposits in cell cultures and brain tissues.
Jiang P, Dickson DW
Acta neuropathologica communications 2025 Mar 8;13(1):53
Acta neuropathologica communications 2025 Mar 8;13(1):53
Muscone enhances synaptic function in vascular dementia through activating BDNF-TrkB-NP2 signaling pathway.
Huang P, Sun H, Chen Y, Li J, Peng Y, Ge C, Zhu K, Zhou X, Chang D, Wang N
International immunopharmacology 2025 Mar 6;149:114232
International immunopharmacology 2025 Mar 6;149:114232
Olfactory bulb microglia activation mediates neuronal pyroptosis in ozone-exposed mice with olfactory and cognitive dysfunction.
Xu R, Chen H, Wang Y, Qi H, Chen Y, Dai A, Yang S, Wang Y, Zeng Y, Li J
Journal of hazardous materials 2025 Mar 5;485:136901
Journal of hazardous materials 2025 Mar 5;485:136901
Ginsenoside 1 mitigates postoperative cognitive dysfunction by enhancing microglial Aβ clearance through the endo-lysosomal pathway.
Jing X, Zhao Y, Wang G, Tian W
International immunopharmacology 2025 Mar 26;150:114281
International immunopharmacology 2025 Mar 26;150:114281
BOOST: a robust ten-fold expansion method on hour-scale.
Guo J, Yang H, Lu C, Cui D, Zhao M, Li C, Chen W, Yang Q, Li Z, Chen M, Zhao SC, Zhou J, He J, Jiang H
Nature communications 2025 Mar 2;16(1):2107
Nature communications 2025 Mar 2;16(1):2107
FKBP51 is Involved in Epileptic Seizure by Regulating PSD95 in a PTZ-Induced Epileptic Mouse Model.
Chen L, Cui W, Qin J, Zhu M, Zhang H, Yang J, Xu Z, Huang H
Journal of integrative neuroscience 2025 Mar 19;24(3):25710
Journal of integrative neuroscience 2025 Mar 19;24(3):25710
PD-like pathogenesis induced by intestinal exposure to microplastics: An in vivo study of animal models to a public health survey.
Bai H, Gu H, Zhou W, Shi G, Yan J, Su Y, Li W, Li Y, Zhong C, Zhao N, Huang X
Journal of hazardous materials 2025 Mar 15;486:136974
Journal of hazardous materials 2025 Mar 15;486:136974
Role of FPR2 antagonism in alleviating social isolation-induced depression and protecting blood-brain barrier integrity.
Zheng J, Wang H, Wu W, Wang L, Qin M, Zhu L, Liu Z, Chen Y, Yu Y
Journal of neuroinflammation 2025 Mar 13;22(1):79
Journal of neuroinflammation 2025 Mar 13;22(1):79
LCN2 induces neuronal loss and facilitates sepsis-associated cognitive impairments.
Guo C, Li W, Liu Y, Mahaman Yacoubou AR, Wang J, Liu R, Li S, Wang X
Cell death & disease 2025 Mar 1;16(1):146
Cell death & disease 2025 Mar 1;16(1):146
Conductive MeCbl/PEDOT:PSS/HA hydrogels with electrical stimulation for enhanced peripheral nerve regeneration.
Liu K, Shao J, Han B, Liu J, Yan S, Liu B, Liu Y
Materials today. Bio 2025 Jun;32:101755
Materials today. Bio 2025 Jun;32:101755
Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS-Induced Depressive-Like Behaviors.
Gao F, Zhang Z, Ju M, Bian L, Wang H, Zhao S, Cai N, Wang Y, Jia Y, Shen L, Zhang Y, Yao H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2414559
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2414559
GPR43 regulates mitochondrial apoptosis through the cyclophilin D pathway in Alzheimer's disease.
Wang X, Wu S, Deng Z, Yan M, Wang D, Yang M, Zhong F, Song J, Chen L, Chen Y, Tian Q, Yu W, Lü Y
Molecular medicine (Cambridge, Mass.) 2025 Jun 4;31(1):219
Molecular medicine (Cambridge, Mass.) 2025 Jun 4;31(1):219
Aging-dependent YAP1 reduction contributes to AD pathology by upregulating the Nr4a1-AKT/GSK-3β axis.
Lei L, Cheng Y, Yin A, Han JM, Wu G, Yang F, Wang Q, Wang JZ, Liu R, Li HL, Wang X
Translational neurodegeneration 2025 Jun 4;14(1):29
Translational neurodegeneration 2025 Jun 4;14(1):29
Lactate links exercise to synaptic protection and cognitive enhancement in Alzheimer's disease models.
Han H, Wu Y, Mi R, Zhang C, Guan F, Lu X, Zhang G, Meng Z, Chen L, Zhang M
BMC medicine 2025 Jun 3;23(1):331
BMC medicine 2025 Jun 3;23(1):331
Icariin mitigates depressive-like behavior in rats by regulating mitochondrial function.
Zhao H, Zhang S, Gong Z, Chen T, Guo H, Yang M, Wang L, Zhou X, Xie J, Li H, Lu Y, Zhu Z
Journal of ethnopharmacology 2025 Jun 26;350:120036
Journal of ethnopharmacology 2025 Jun 26;350:120036
Exercise improves depressive-like behavior in adolescent mice by regulating sphingosine and ceramide metabolism through microglial CerS1.
Li N, Yao Y, Du J, Wu D, Qiao X, Peng F, Meng F, Zhang Y, Wang L, Hao A, Zhou W
Communications biology 2025 Jun 19;8(1):941
Communications biology 2025 Jun 19;8(1):941
Human neural stem cell-derived small extracellular vesicles enhance functional recovery after ischemic stroke through the miR-362-3p/MCAM/Wnt/β-catenin axis.
Zhu Z, Zhang G, Ahmed W, Feng J, Wang C, Zhang Y, Wu G, Hong C, Zhang Q, Feng T, Liu J, Zhao A, Chen L
International immunopharmacology 2025 Jun 17;158:114826
International immunopharmacology 2025 Jun 17;158:114826
Lycium barbarum polysaccharide ameliorates corticosterone-induced cognition decline with modulation of CRHR1.
Shi XX, Tian XF, He B, Liu SN, Shi CG, Shi Y, Yang YS
Brain research bulletin 2025 Jun 1;225:111346
Brain research bulletin 2025 Jun 1;225:111346
Flavonoids from Shiliangcha (Chimonanthus salicifolius) Alleviate Brain Aging in d-Galactose-Induced Senescent Mice through Gut Microbiota.
Liu S, Wang M, Meng X, Pan J, Fang J, Cheng W, Zhang X, Cheng K
Journal of agricultural and food chemistry 2025 Jul 9;73(27):16890-16905
Journal of agricultural and food chemistry 2025 Jul 9;73(27):16890-16905
S-ketamine ameliorates post-stroke depression in mice via attenuation of neuroinflammation, synaptic restoration, and BDNF pathway activation.
Tian J, Xie Y, Ye S, Hu Y, Feng J, Li Y, Lou Z, Ruan L, Wang Z
Biochemical and biophysical research communications 2025 Jul 8;769:151965
Biochemical and biophysical research communications 2025 Jul 8;769:151965
Proteomics analysis reveals FEN1 as a promising therapeutic target against small cell neuroendocrine carcinoma of the cervix.
Liu J, Zhong M, Yang K, Wang J, Ma H, Wang W, Sun L, Liu L, Xu J, Cui X, Hao J, Li L
Scientific reports 2025 Jul 30;15(1):27827
Scientific reports 2025 Jul 30;15(1):27827
Ginsenoside Rg3 alleviates brain damage caused by chlorpyrifos exposure by targeting and regulating the microbial-gut-brain axis.
Liu S, Yang Y, Zong Y, Chen W, Geng J, Zhao Y, Du R, He Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156838
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156838
Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice.
Wu Y, Zhang Y, Yu Y, Wang X, Zhen Z, Yuan Y, Xie B, Han M, Wang M, Zhang X, Sun X, Wen X, Hashimoto K, Shang Y, Yuan S, Zhang J
Nature communications 2025 Jul 23;16(1):6779
Nature communications 2025 Jul 23;16(1):6779
Discovery of FO-4-15, a novel 1,2,4-oxadiazole derivative, ameliorates cognitive impairments in 3×Tg mice by activating the mGluR1/CaMKIIα pathway.
Luo ZH, Guo JS, Pang S, Dong W, Ma JX, Zhang L, Qi XL, Guan FF, Gao S, Gao X, Liu N, Pan S, Chen W, Zhang X, Zhang LF, Yang YJ
Acta pharmacologica Sinica 2025 Jan;46(1):66-80
Acta pharmacologica Sinica 2025 Jan;46(1):66-80
Magnolol acts as a neurorestorative agent in an A(β1‑42)‑induced mouse model of Alzheimer's disease.
Yu Q, Shi Y, Wu Y, Liu R, Zhang H, Wu L, Ding M
Experimental and therapeutic medicine 2025 Jan;29(1):12
Experimental and therapeutic medicine 2025 Jan;29(1):12
Lycopene Alleviates Depression-Like Behavior in Chronic Social Defeat Stress-Induced Mice by Promoting Synaptic Plasticity via the BDNF-TrkB Pathway.
Xu H, Wang Y, Geng D, Chen F, Chen Y, Niwenahisemo LC, Shi L, Du N, He Z, Xu X, Kuang L
Food science & nutrition 2025 Jan;13(1):e70003
Food science & nutrition 2025 Jan;13(1):e70003
Minocycline ameliorates cognitive impairment in rats with trigeminal neuralgia by regulating microglial polarization.
Li J, Mi X, Yang Z, Feng Z, Han Y, Wang T, Lv H, Liu Y, Wu K, Liu J
International immunopharmacology 2025 Jan 3;145:113786
International immunopharmacology 2025 Jan 3;145:113786
Lentivirus-mediated overexpression of netrin-1/DCC co-expression promotes axonal regeneration and functional recovery in spinal cord injury via the inhibition of the NgR1-RhoA-ROCK signaling pathway.
Zheng ML, Ma Z, Yuan-Xia, Wang LJ, Fan Y, Feng CA, Zhou JP, Li ZM, Liu CX, XiYang YB, Ba YC
Translational neuroscience 2025 Jan 1;16(1):20250365
Translational neuroscience 2025 Jan 1;16(1):20250365
VEGFD/VEGFR3 signaling contributes to the dysfunction of the astrocyte IL-3/microglia IL-3Rα cross-talk and drives neuroinflammation in mouse ischemic stroke.
Wang S, Guo Y, Cao RQ, Zhu YM, Qiao SG, Du HP, Liu Y, Xu Y, Zhou XY, Sun L, Lu QX, Schoen I, Zhang HL
Acta pharmacologica Sinica 2025 Feb;46(2):292-307
Acta pharmacologica Sinica 2025 Feb;46(2):292-307
MiR-18a-LncRNA NONRATG-022419 pairs targeted PRG-1 regulates diabetic induced cognitive impairment by regulating NGF\BDNF-Trkb signaling pathway.
Xiang Q, Lin H, Tao JS, Fu CJ, Liu LN, Deng J, Li XH
Proteome science 2025 Feb 6;23(1):1
Proteome science 2025 Feb 6;23(1):1
Urolithin A alleviates NLRP3 inflammasome activation and pyroptosis by promoting microglial mitophagy following spinal cord injury.
Chen K, Ying J, Zhu J, Chen L, Liu R, Jing M, Wang Y, Zhou K, Wu L, Wu C, Xiao J, Ni W
International immunopharmacology 2025 Feb 20;148:114057
International immunopharmacology 2025 Feb 20;148:114057
Transplantation of medial ganglionic eminence cells rescues early-life stress-induced social and cognitive impairments in postnatal mice.
Lin L, Lai Y, Mei A, Chen Y, Lin F
Neurobiology of learning and memory 2025 Dec;222:108101
Neurobiology of learning and memory 2025 Dec;222:108101
Gut dysbiosis-induced vitamin B6 metabolic disorder contributes to chronic stress-related abnormal behaviors in a cortisol-independent manner.
Qing W, Chen H, Ma X, Chen J, Le Y, Chen H, Tong J, Duan K, Ma D, Ouyang W, Tong J
Gut microbes 2025 Dec;17(1):2447824
Gut microbes 2025 Dec;17(1):2447824
HCN2 promotes neurodevelopmental and synaptic function repair through the CaMKII/CREB pathway to alleviate general anesthesia-induced cognitive impairment.
Yang L, Cheng X, Ye L, Shi Y, Ye C, Wei F
Cellular signalling 2025 Dec;136:112113
Cellular signalling 2025 Dec;136:112113
OPRK1 drives SLC9A3R1 progression to neuroendocrine prostate cancer.
Liang L, Shen Z, Zhang Y, Cheng Y, Yao B, Feng N, Zhao R
Cell death & disease 2025 Dec 7;17(1):68
Cell death & disease 2025 Dec 7;17(1):68
Astragaloside IV improves cognitive impairment in diabetes by inhibiting calpain-1/NLRP3 mediated microglial activation.
Wang X, Jiang H, Wang H, Zhao C, Ba X
International immunopharmacology 2025 Dec 10;167:115682
International immunopharmacology 2025 Dec 10;167:115682
Subtle Alterations in Hippocampal Neuronal Activity Coincide With Early Sex-Specific Differences in Amyloidosis and Microglia in a Pre-Symptomatic Mouse Model of Alzheimer-Like Pathology.
Chaigneau T, Sha S, Roux CM, Aïd S, Faucher A, Chantran Y, Dorothée G, Krantic S
Glia 2025 Aug;73(8):1727-1745
Glia 2025 Aug;73(8):1727-1745
Nomilin Alleviates Neuroinflammation and Depressive-like Behaviors in Mice through the Upregulation of TAX1BP1-Mediated Modulation of Microglia Polarization.
Li J, Yang Z, Zhao J, Jia Y, Zhang Y, Tian Z, Pan X, Ren Y, Li L, Li Z
ACS chemical neuroscience 2025 Aug 6;16(15):3051-3058
ACS chemical neuroscience 2025 Aug 6;16(15):3051-3058
PPARα deletion induces depressive-like behaviors by impairing neuronal synaptic plasticity and transmission.
Zhuo R, Cheng X, Yang L, Wang C, Yang L, Zhang Y, Zeng Y, Li Y
Neuroscience 2025 Aug 30;582:82-93
Neuroscience 2025 Aug 30;582:82-93
17β-Trenbolone modulates anxiety-related synaptic plasticity by affecting the interaction between hippocampal TACR3 and systemic testosterone in male mice.
Zuo X, Bai H, Qiu J, Li R, Kuang X, Zhao Y, Tuo J, Zhao Q, Zhao X, Feng X
Environmental research 2025 Aug 15;279(Pt 1):121796
Environmental research 2025 Aug 15;279(Pt 1):121796
FGF21 Alleviates Hypoxic-Ischemic White Matter Injury in Neonatal Mice by Mediating Inflammation and Oxidative Stress Through PPAR-γ Signaling Pathway.
Fang M, Lu L, Lou J, Ou J, Yu Q, Tao X, Zhu J, Lin Z
Molecular neurobiology 2025 Apr;62(4):4743-4768
Molecular neurobiology 2025 Apr;62(4):4743-4768
Dietary salt promotes cognitive impairment through repression of SIRT3/PINK1-mediated mitophagy and fission.
Fan H, Yuan M, Wang S, Yang X, Shu L, Pu Y, Zou Q, Zhang X, Wang C, Cai Z
Molecular and cellular biochemistry 2025 Apr;480(4):2345-2360
Molecular and cellular biochemistry 2025 Apr;480(4):2345-2360
Therapeutic Hypothermia Increases the Expression of RNA-binding Protein Motif 3 and Attenuates Cognitive Deficits Following Cardiac Arrest in Rats.
Yao F, Cai SQ, Cheng HX, Ren LW, Hui KL, Liu QZ, Guo M, Chen LH, Qian B, Zeng Y, Li F, Duan ML
Neurochemical research 2025 Apr 3;50(2):134
Neurochemical research 2025 Apr 3;50(2):134
CRMP2 in the hippocampus alleviates chronic stress-induced depressive-like behaviours in mice by affecting synaptic function.
Li R, Zhang Y, Zhang H, Wang C, Duan H, Sun S, Xiang D, Liu Z
Behavioural brain research 2025 Apr 27;484:115495
Behavioural brain research 2025 Apr 27;484:115495
In vitro susceptibility of differentiated SH-SY5Y human neuroblastoma cells to herpes simplex virus type 1 and Japanese encephalitis virus infection.
Ferdous J, Makino H, Masatani T, Fujimoto Y, Naitou K, Shiraishi M
The Journal of veterinary medical science 2025 Apr 1;87(4):426-430
The Journal of veterinary medical science 2025 Apr 1;87(4):426-430
The role of TFEB-mediated autophagy-lysosome dysfunction in manganese neurotoxicity.
Lu J, Su P, Zhao F, Yu K, Yang X, Lv H, Wang D, Zhang J
Current research in toxicology 2024;7:100193
Current research in toxicology 2024;7:100193
Jujuboside A Regulates Calcium Homeostasis and Structural Plasticity to Alleviate Depression-Like Behavior via Shh Signaling in Immature Neurons.
Zhong Z, Liu J, Luo Y, Wu M, Qiu F, Zhao H, Liu Y, Wang Y, Long H, Zhao L, Wang Y, Han Y, Meng P
Drug design, development and therapy 2024;18:4565-4584
Drug design, development and therapy 2024;18:4565-4584
Surgery induces neurocognitive disorder via neuroinflammation and glymphatic dysfunction in middle-aged mice with brain lymphatic drainage impairment.
Zhu X, Lin J, Yang P, Wu S, Lin H, He W, Lin D, Cao M
Frontiers in neuroscience 2024;18:1426718
Frontiers in neuroscience 2024;18:1426718
Follicle-stimulating hormone induces depression-like phenotype by affecting synaptic function.
Huang L, Sun S, Jiang G, Xie G, Yang Y, Chen S, Luo J, Lv C, Li X, Liao J, Wang Z, Zhang Z, Xiong J
Frontiers in molecular neuroscience 2024;17:1459858
Frontiers in molecular neuroscience 2024;17:1459858
Enriched oxygen improves age-related cognitive impairment through enhancing autophagy.
Wang S, Chen B, Yuan M, Liu S, Fan H, Yang X, Zou Q, Pu Y, Cai Z
Frontiers in aging neuroscience 2024;16:1340117
Frontiers in aging neuroscience 2024;16:1340117
The microglial innate immune receptor TREM2 participates in fear memory formation through excessive prelimbic cortical synaptic pruning.
Zhang LL, Cheng P, Chu YQ, Zhou ZM, Hua R, Zhang YM
Frontiers in immunology 2024;15:1412699
Frontiers in immunology 2024;15:1412699
Circular RNA SCMH1 suppresses KMO expression to inhibit mitophagy and promote functional recovery following stroke.
Wang Y, Bai Y, Cai Y, Zhang Y, Shen L, Xi W, Zhou Z, Xu L, Liu X, Han B, Yao H
Theranostics 2024;14(19):7292-7308
Theranostics 2024;14(19):7292-7308
Sortilin is associated with progranulin deficiency and autism-like behaviors in valproic acid-induced autism rats.
Liao A, Zheng W, Wang S, Wang N, Li Y, Chen D, Wang Y
CNS neuroscience & therapeutics 2024 Sep;30(9):e70015
CNS neuroscience & therapeutics 2024 Sep;30(9):e70015
Histone demethylase PHF8 promotes prostate cancer metastasis via the E2F1-SNAI1 axis.
Wang Z, Tang P, Xiao H, Peng S, Chen J, Wang Y, Xu J, Yan Q, Zhang J, Deng J, Ma Q, Zhu H, Luo W, Zhang D, Wang L, Qin J, Lan W, Jiang J, Liu Q
The Journal of pathology 2024 Sep;264(1):68-79
The Journal of pathology 2024 Sep;264(1):68-79
Thy1-ApoE4/C/EBPβ double transgenic mice act as a sporadic model with Alzheimer's disease.
Qian Z, Wang Z, Li B, Meng X, Kuang Z, Li Y, Yang Y, Ye K
Molecular psychiatry 2024 Oct;29(10):3040-3055
Molecular psychiatry 2024 Oct;29(10):3040-3055
Wnt/Ca(2+) pathway inhibits neural differentiation of human dental pulp stem cells in vitro.
Wang SH, Wang SR, Luan NN, Sun XQ, Guo YR, Yan YB, Liang SX
Journal of dental sciences 2024 Oct;19(4):2090-2099
Journal of dental sciences 2024 Oct;19(4):2090-2099
USP9X-mediated deubiquitination of Raptor contributes to autophagy impairment and memory deficits in P301S mice.
Zheng S, Zhu J, Wang C, Wu Y, Sun S, Guo H, Chang Y, Ma R, Li G
Cell communication and signaling : CCS 2024 Oct 24;22(1):516
Cell communication and signaling : CCS 2024 Oct 24;22(1):516
Corilagin improves cognitive impairment in APP/PS1 mice by reducing Aβ generation and enhancing synaptic plasticity.
Chen L, Zhuang Z, Duan H, Lv D, Hong S, Chen P, He B, Shen Z
European journal of pharmacology 2024 Oct 15;981:176893
European journal of pharmacology 2024 Oct 15;981:176893
The Neuroprotective Mechanisms of PPAR-γ: Inhibition of Microglia-Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic-Ischemic White Matter Injury.
Fang M, Yu Q, Ou J, Lou J, Zhu J, Lin Z
CNS neuroscience & therapeutics 2024 Nov;30(11):e70081
CNS neuroscience & therapeutics 2024 Nov;30(11):e70081
LASP1 in the nucleus accumbens modulates methamphetamine-induced conditioned place preference in mice.
Li MQ, Lu XY, Yao JY, Zou GJ, Zeng ZH, Zhang LX, Zhou SF, Chen ZR, Zhao TS, Guo ZR, Cui YH, Li F, Li CQ
Neurochemistry international 2024 Nov;180:105884
Neurochemistry international 2024 Nov;180:105884
Shh regulates M2 microglial polarization and fibrotic scar formation after ischemic stroke.
Yang Q, Jiang P, Tang H, Wen J, Zhou L, Zhao Y, Wang L, Wang J, Yang Q
Neurochemistry international 2024 Nov;180:105862
Neurochemistry international 2024 Nov;180:105862
S-ketamine alleviates depression-like behavior and hippocampal neuroplasticity in the offspring of mice that experience prenatal stress.
Zhang Y, Wei CK, Wang P, Zheng LC, Cheng Y, Ren ZH, Jin YH, Yao YY, Liu HZ
Scientific reports 2024 Nov 6;14(1):26929
Scientific reports 2024 Nov 6;14(1):26929
Inhibitory effect of tea flower polysaccharides on oxidative stress and microglial oxidative damage in aging mice by regulating gut microbiota.
Cai Y, Liu S, Ge X, Cheng L, Zhang X
Food & function 2024 Nov 25;15(23):11444-11457
Food & function 2024 Nov 25;15(23):11444-11457
Lentivirus-mediated Knockdown of Ski Improves Neurological Function After Spinal Cord Injury in Rats.
Wang ZQ, Ran R, Ma CW, Zhao GH, Zhou KS, Zhang HH
Neurochemical research 2024 Nov 16;50(1):15
Neurochemical research 2024 Nov 16;50(1):15
A peptide against the N-terminus of myristoylated alanine-rich C kinase substrate promotes neuronal differentiation in SH-SY5Y human neuroblastoma cells.
Ferdous J, Naitou K, Shiraishi M
The Journal of veterinary medical science 2024 Nov 1;86(11):1136-1144
The Journal of veterinary medical science 2024 Nov 1;86(11):1136-1144
Oral edaravone ameliorates behavioral deficits and pathologies in a valproic acid-induced rat model of autism spectrum disorder.
Lu XY, Li MQ, Li YT, Yao JY, Zhang LX, Zeng ZH, Yu-Liu, Chen ZR, Li CQ, Zhou XF, Li F
Neuropharmacology 2024 Nov 1;258:110089
Neuropharmacology 2024 Nov 1;258:110089
Construction of functional neural network tissue combining CBD-NT3-modified linear-ordered collagen scaffold and TrkC-modified iPSC-derived neural stem cells for spinal cord injury repair.
Wu Z, Zhou Y, Hou X, Liu W, Yin W, Wang L, Cao Y, Jiang Z, Guo Y, Chen Q, Xie W, Wang Z, Shi N, Liu Y, Gao X, Luo L, Dai J, Ren C, Jiang X
Bioactive materials 2024 May;35:242-258
Bioactive materials 2024 May;35:242-258
Effects of autotaxin and lysophosphatidic acid deficiencies on depression-like behaviors in mice exposed to chronic unpredictable mild stress.
Wang C, Li N, Feng Y, Sun S, Rong J, Xie XH, Xu S, Liu Z
Neurobiology of stress 2024 May;30:100632
Neurobiology of stress 2024 May;30:100632
Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids.
Chen A, Yangzom T, Hong Y, Lundberg BC, Sullivan GJ, Tzoulis C, Bindoff LA, Liang KX
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(18):e2307136
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(18):e2307136
Purinergic Astrocyte Signaling Driven by TNF-α After Cannabidiol Administration Restores Normal Synaptic Remodeling Following Traumatic Brain Injury.
Ling T, Yin A, Cao Y, Li J, Li H, Zhou Y, Guo X, Li J, Zhang R, Wu H, Li P
Neuroscience 2024 May 3;545:31-46
Neuroscience 2024 May 3;545:31-46
Gut Microbiota Mediate the Neuroprotective Effect of Oolong Tea Polyphenols in Cognitive Impairment Induced by Circadian Rhythm Disorder.
Song Z, Ho CT, Zhang X
Journal of agricultural and food chemistry 2024 May 29;72(21):12184-12197
Journal of agricultural and food chemistry 2024 May 29;72(21):12184-12197
PAX6 promotes neuroendocrine phenotypes of prostate cancer via enhancing MET/STAT5A-mediated chromatin accessibility.
Jing N, Du X, Liang Y, Tao Z, Bao S, Xiao H, Dong B, Gao WQ, Fang YX
Journal of experimental & clinical cancer research : CR 2024 May 15;43(1):144
Journal of experimental & clinical cancer research : CR 2024 May 15;43(1):144
Constraint-Induced Movement Therapy Modulates Neuron Recruitment and Neurotransmission Homeostasis of the Contralesional Cortex to Enhance Function Recovery after Ischemic Stroke.
Zhang A, Xing Y, Zheng J, Li C, Hua Y, Hu J, Tian Z, Bai Y
ACS omega 2024 May 14;9(19):21612-21625
ACS omega 2024 May 14;9(19):21612-21625
The E3 ubiquitin ligase TRIM9 regulates synaptic function and actin dynamics in response to netrin-1.
McCormick LE, Evans EB, Barker NK, Herring LE, Diering GH, Gupton SL
Molecular biology of the cell 2024 May 1;35(5):ar67
Molecular biology of the cell 2024 May 1;35(5):ar67
Bilirubin impairs neuritogenesis and synaptogenesis in NSPCs by downregulating NMDAR-CREB-BDNF signaling.
Zhang Y, Li S, Li L, Huang H, Fu Z, Hua Z
In vitro cellular & developmental biology. Animal 2024 Mar;60(2):161-171
In vitro cellular & developmental biology. Animal 2024 Mar;60(2):161-171
Bavachin ameliorates neuroinflammation and depressive-like behaviors in streptozotocin-induced diabetic mice through the inhibition of PKCδ.
Zhang Z, Sun L, Guo Y, Zhao J, Li J, Pan X, Li Z
Free radical biology & medicine 2024 Mar;213:52-64
Free radical biology & medicine 2024 Mar;213:52-64
Dietary Restriction Improves Perioperative Neurocognitive Disorders by Inhibiting Neuroinflammation and Gut Microbial Dysbiosis.
Ren L, Liang H, Zhu L, Yang X, Zhang H, Sun N, Huang D, Feng J, Wu Y, Xiong L, Ke X, Li M, Zhang A
Neuroscience 2024 Mar 5;540:48-67
Neuroscience 2024 Mar 5;540:48-67
Volatile oil of Angelica sinensis Radix improves cognitive function by inhibiting miR-301a-3p targeting Ppp2ca in cerebral ischemia mice.
Zhao J, Luo J, Deng C, Fan Y, Liu N, Cao J, Chen D, Diao Y
Journal of ethnopharmacology 2024 Mar 25;322:117621
Journal of ethnopharmacology 2024 Mar 25;322:117621
Periplaneta Americana (L.) extract activates the ERK/CREB/BDNF pathway to promote post-stroke neuroregeneration and recovery of neurological functions in rats.
Rao J, Li H, Zhang H, Xiang X, Ding X, Li L, Geng F, Qi H
Journal of ethnopharmacology 2024 Mar 1;321:117400
Journal of ethnopharmacology 2024 Mar 1;321:117400
High salt diet induces cognitive impairment and is linked to the activation of IGF1R/mTOR/p70S6K signaling.
Liu S, Yang X, Yuan M, Wang S, Fan H, Zou Q, Pu Y, Cai Z
Metabolic brain disease 2024 Jun;39(5):803-819
Metabolic brain disease 2024 Jun;39(5):803-819
HDAC1/2/3-mediated downregulation of neurogranin is involved in cognitive impairment in offspring exposed to maternal subclinical hypothyroidism.
Yu X, Guo J, Song Y, Wei B, Shi Y, Zhao Y, Zhao Z, Gao Q, Wang B, Sun M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jun 30;38(12):e23736
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jun 30;38(12):e23736
KIF1A, R1457Q, and P1688L Mutations Induce Protein Abnormal Aggregation and Autophagy Impairment in iPSC-Derived Motor Neurons.
Zhao M, Wang J, Liu M, Xu Y, Huang J, Zhang Y, He J, Gu A, Liu M, Liu X
Biomedicines 2024 Jul 30;12(8)
Biomedicines 2024 Jul 30;12(8)
PM2.5 triggers tau aggregation in a mouse model of tauopathy.
Liu C, Meng L, Gao Y, Chen J, Zhu M, Xiong M, Xiao T, Gu X, Liu C, Li T, Zhang Z
JCI insight 2024 Jul 22;9(14)
JCI insight 2024 Jul 22;9(14)
Targeting SOX4/PCK2 signaling suppresses neuroendocrine trans-differentiation of castration-resistant prostate cancer.
Jing N, Tao Z, Du X, Wen Z, Gao WQ, Dong B, Fang YX
Biology direct 2024 Jul 16;19(1):56
Biology direct 2024 Jul 16;19(1):56
Apple polysaccharide improves age-matched cognitive impairment and intestinal aging through microbiota-gut-brain axis.
Zhang W, Zhong Y, Wang Z, Tang F, Zheng C
Scientific reports 2024 Jul 13;14(1):16215
Scientific reports 2024 Jul 13;14(1):16215
Pramipexole improves depression-like behavior in diabetes mellitus with depression rats by inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing impaired neuroplasticity.
Li P, Wang T, Guo H, Liu Y, Zhao H, Ren T, Tang Y, Wang Y, Zou M
Journal of affective disorders 2024 Jul 1;356:586-596
Journal of affective disorders 2024 Jul 1;356:586-596
Brassisterol A, a new ergosterol from co-cultivation of fungi attenuates neuroinflammation via targeting NLRP3/caspase-1/GSDMD pathway.
Tong Z, Kong L, Zhang Y, Hu T, Dai R, Wang Y, Ji J, Huang Z, Hu L
Bioorganic chemistry 2024 Jan;142:106955
Bioorganic chemistry 2024 Jan;142:106955
YTHDF3 modulates the Cbln1 level by recruiting BTG2 and is implicated in the impaired cognition of prenatal hypoxia offspring.
Lu L, Shi Y, Wei B, Li W, Yu X, Zhao Y, Yu D, Sun M
iScience 2024 Jan 19;27(1):108703
iScience 2024 Jan 19;27(1):108703
GR/Ahi1 regulates WDR68-DYRK1A binding and mediates cognitive impairment in prenatally stressed offspring.
Wei B, Shi H, Yu X, Shi Y, Zeng H, Zhao Y, Zhao Z, Song Y, Sun M, Wang B
Cellular and molecular life sciences : CMLS 2024 Jan 10;81(1):20
Cellular and molecular life sciences : CMLS 2024 Jan 10;81(1):20
The E3 ubiquitin ligase TRIM9 regulates synaptic function and actin dynamics.
McCormick LE, Evans EB, Barker NK, Herring LE, Diering GH, Gupton SL
bioRxiv : the preprint server for biology 2024 Jan 1;
bioRxiv : the preprint server for biology 2024 Jan 1;
Prednisolone improves hippocampal regeneration after trimethyltin-induced neurodegeneration in association with prevention of T lymphocyte infiltration.
Sakurai M, Takenaka M, Mitsui Y, Sakai Y, Morimoto M
Neuropathology : official journal of the Japanese Society of Neuropathology 2024 Feb;44(1):21-30
Neuropathology : official journal of the Japanese Society of Neuropathology 2024 Feb;44(1):21-30
Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1.
He F, Chen C, Wang Y, Wang S, Lyu S, Jiao J, Huang G, Yang J
Experimental and therapeutic medicine 2024 Feb;27(2):71
Experimental and therapeutic medicine 2024 Feb;27(2):71
Microglial Ffar4 deficiency promotes cognitive impairment in the context of metabolic syndrome.
Wang W, Li J, Cui S, Li J, Ye X, Wang Z, Zhang T, Jiang X, Kong Y, Chen X, Chen YQ, Zhu S
Science advances 2024 Feb 2;10(5):eadj7813
Science advances 2024 Feb 2;10(5):eadj7813
Dynamic behavior and lineage plasticity of the pulmonary venous endothelium.
Wong J, Zhao G, Adams-Tzivelekidis S, Wen H, Chandrasekaran P, Michki SN, Gentile ME, Singh M, Kass-Gergi S, Mendoza M, Holcomb NP, Li X, Tang AT, Negretti NM, Sucre JMS, Frank DB, Vaughan AE
Nature cardiovascular research 2024 Dec;3(12):1584-1600
Nature cardiovascular research 2024 Dec;3(12):1584-1600
New TIPARP inhibitor rescues mitochondrial function and brain injury in ischemic stroke.
Cai Y, Gu H, Li L, Liu X, Bai Y, Shen L, Han B, Xu Y, Yao H
Pharmacological research 2024 Dec;210:107508
Pharmacological research 2024 Dec;210:107508
Taohe Chengqi decoction improves diabetic cognitive dysfunction by alleviating neural stem cell senescence through HIF1α-driven metabolic signaling.
Qin T, He Z, Hassan HM, Wang Q, Shi L, Yu Y, Zhou Y, Zhang W, Yuan Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156219
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156219
Tong-Qiao-Huo-Xue Decoction promotes synaptic remodeling via cAMP/PKA/CREB pathway in vascular dementia rats.
Li J, Ye H, Xu F, Yang Y, Ge C, Yao M, Huang P, Wang L, Wang N, Zhou X, Chang D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156166
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156166
Osmundacetone ameliorates Alzheimer's-like pathologies by inhibiting β-amyloid fibrillation, oxidative damage and neuroinflammation in APP/PS1 transgenic mice.
Zhao LX, Ren H, Su JY, Zhang Q, He DL, Wu TY, Zhang YH, Wang ZY, Fan YG
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156091
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156091
Cerebral ischemic injury impairs autophagy and exacerbates cognitive impairment in APP/PS1 mice.
Ning Z, Zhong X, Wang Y, Hu D, Tang X, Deng M
International immunopharmacology 2024 Dec 25;143(Pt 3):113581
International immunopharmacology 2024 Dec 25;143(Pt 3):113581
Optimized Proteomic Analysis of Insulin Granules From MIN6 Cells Identifies Scamp3, a Novel Regulator of Insulin Secretion and Content.
Norris N, Yau B, Famularo C, Webster H, Loudovaris T, Thomas HE, Larance M, Senior AM, Kebede MA
Diabetes 2024 Dec 1;73(12):2045-2054
Diabetes 2024 Dec 1;73(12):2045-2054
A novel derivative of evodiamine improves cognitive impairment and synaptic integrity in AD mice.
Wan YC, Yang Y, Pang S, Kong ZL
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117103
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117103
Lactobacillus-derived indole derivatives ameliorate intestinal barrier damage in rat pups with complementary food administration.
Wang A, Guan C, Wang T, Mu G, Tuo Y
Food & function 2024 Aug 27;15(17):8775-8787
Food & function 2024 Aug 27;15(17):8775-8787
A high-fat diet induced depression-like phenotype via hypocretin-HCRTR1 mediated inflammation activation.
Dong J, Zhang J, Cheng S, Qin B, Jin K, Chen B, Zhang Y, Lu J
Food & function 2024 Aug 27;15(17):8661-8673
Food & function 2024 Aug 27;15(17):8661-8673
Psoralen protects neurons and alleviates neuroinflammation by regulating microglial M1/M2 polarization via inhibition of the Fyn-PKCδ pathway.
Guo Y, Xu S, Pan X, Xin W, Cao W, Ma W, Li L, Shen Q, Li Z
International immunopharmacology 2024 Aug 20;137:112493
International immunopharmacology 2024 Aug 20;137:112493
GDF1 ameliorates cognitive impairment induced by hearing loss.
Pan L, Li C, Meng L, Zhang G, Zou L, Tian Y, Chen S, Sun Y, Su D, Zhang X, Xiong M, Xiao T, Xia D, Hong Z, Zhang Z
Nature aging 2024 Apr;4(4):568-583
Nature aging 2024 Apr;4(4):568-583
Exercise attenuates the perioperative neurocognitive disorder induced by hyperhomocysteinemia in mice.
Zhang Q, Cong P, Tian L, Wu T, Huang X, Zhang Y, Wu H, Liang H, Xiong L
Brain research bulletin 2024 Apr;209:110913
Brain research bulletin 2024 Apr;209:110913
Butyrate reduction and HDAC4 increase underlie maternal high fructose-induced metabolic dysfunction in hippocampal astrocytes in female rats.
Wu KLH, Liu WC, Wu CW, Fu MH, Huang HM, Tain YL, Liang CK, Hung CY, Chen IC, Hung PL, Lin YJ, Hirase H
The Journal of nutritional biochemistry 2024 Apr;126:109571
The Journal of nutritional biochemistry 2024 Apr;126:109571
Huanglian Jiedu decoction alleviates neurobehavioral damage in mice with chronic alcohol exposure through the RAS-RAF-MEK-ERK pathway.
Chen Y, Jiang L, Li M, Shen Y, Liu S, Yang D
Heliyon 2024 Apr 30;10(8):e29556
Heliyon 2024 Apr 30;10(8):e29556
Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer's disease.
Jiang D, Liu H, Li T, Zhao S, Yang K, Yao F, Zhou B, Feng H, Wang S, Shen J, Tang J, Zhang YX, Wang Y, Guo C, Tang TS
Translational neurodegeneration 2024 Apr 26;13(1):24
Translational neurodegeneration 2024 Apr 26;13(1):24
The Involvement of Progranulin for α-Synuclein Reduction through Autolysosome Formation.
Fujimori H, Ohba T, Nakamura S, Shimazawa M, Hara H
Biological & pharmaceutical bulletin 2023;46(8):1032-1040
Biological & pharmaceutical bulletin 2023;46(8):1032-1040
Periventricular Microglia Polarization and Morphological Changes Accompany NLRP3 Inflammasome-Mediated Neuroinflammation after Hypoxic-Ischemic White Matter Damage in Premature Rats.
Yang L, Zhang Y, Yu X, Li D, Liu N, Xue X, Fu J
Journal of immunology research 2023;2023:5149306
Journal of immunology research 2023;2023:5149306
Dietary High-Fat Promotes Cognitive Impairment by Suppressing Mitophagy.
Wen J, Wang Y, Wang C, Yuan M, Chen F, Zou Q, Cai Z, Zhao B
Oxidative medicine and cellular longevity 2023;2023:4822767
Oxidative medicine and cellular longevity 2023;2023:4822767
Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia.
Yang XY, Geng L, Li R, Song JX, Jia CL, An JR, Sun MF, Xu S, Guo YJ, Zhao Y, Ji ES
International journal of nanomedicine 2023;18:843-859
International journal of nanomedicine 2023;18:843-859
A single intranasal dose of human mesenchymal stem cell-derived extracellular vesicles after traumatic brain injury eases neurogenesis decline, synapse loss, and BDNF-ERK-CREB signaling.
Kodali M, Madhu LN, Reger RL, Milutinovic B, Upadhya R, Attaluri S, Shuai B, Shankar G, Shetty AK
Frontiers in molecular neuroscience 2023;16:1185883
Frontiers in molecular neuroscience 2023;16:1185883
Dysfunction of inhibitory interneurons contributes to synaptic plasticity via GABABR-pNR2B signaling in a chronic migraine rat model.
Zeng X, Niu Y, Qin G, Zhang D, Chen L
Frontiers in molecular neuroscience 2023;16:1142072
Frontiers in molecular neuroscience 2023;16:1142072
Neuroprotective Effects of Leptin on the APP/PS1 Alzheimer's Disease Mouse Model: Role of Microglial and Neuroinflammation.
Ma J, Hou YH, Liao ZY, Ma Z, Zhang XX, Wang JL, Zhu YB, Shan HL, Wang PY, Li CB, Lv YL, Wei YL, Dou JZ
Degenerative neurological and neuromuscular disease 2023;13:69-79
Degenerative neurological and neuromuscular disease 2023;13:69-79
Neuroprotective effect of salidroside on hippocampal neurons in diabetic mice via PI3K/Akt/GSK-3β signaling pathway.
Wang XH, Zuo ZF, Meng L, Yang Q, Lv P, Zhao LP, Wang XB, Wang YF, Huang Y, Fu C, Liu WQ, Liu XZ, Zheng DY
Psychopharmacology 2023 Sep;240(9):1865-1876
Psychopharmacology 2023 Sep;240(9):1865-1876
Chronic Kidney Disease Induces Cognitive Impairment in the Early Stage.
Wang Y, Chen K, Qiao ZX, Bao XR
Current medical science 2023 Oct;43(5):988-997
Current medical science 2023 Oct;43(5):988-997
Clemastine fumarate attenuates tauopathy and meliorates cognition in hTau mice via autophagy enhancement.
Zhu J, Jiang X, Chang Y, Wu Y, Sun S, Wang C, Zheng S, Wang M, Yao Y, Li G, Ma R
International immunopharmacology 2023 Oct;123:110649
International immunopharmacology 2023 Oct;123:110649
Electroacupuncture alleviates PTSD-like behaviors by modulating hippocampal synaptic plasticity via Wnt/β-catenin signaling pathway.
Lv T, Wang M, Zheng HS, Mao JD, Yang F, Yang L, Zhao MG, Liu SB, Zhang K, Liu R, Wu YM
Brain research bulletin 2023 Oct 1;202:110734
Brain research bulletin 2023 Oct 1;202:110734
CNTN1 Aggravates Neuroinflammation and Triggers Cognitive Deficits in Male Mice by Boosting Crosstalk between Microglia and Astrocytes.
Li SJ, Ma MH, Li JM, Lu XY, Lu CB, Zhou SF, Zhang LX, Li MQ, Shao TZ, Bai SP, Yan XX, Li F, Li CQ
Aging and disease 2023 Oct 1;14(5):1853-1869
Aging and disease 2023 Oct 1;14(5):1853-1869
The role of EndophilinA1 in chronic unpredicted mild stress-induced depression model mice.
Liu M, Ling Y, Zhang Y, Liu L, Qiu Y, Liu Y, Yin Y
International immunopharmacology 2023 Nov;124(Pt B):111023
International immunopharmacology 2023 Nov;124(Pt B):111023
ChemR23 activation attenuates cognitive impairment in chronic cerebral hypoperfusion by inhibiting NLRP3 inflammasome-induced neuronal pyroptosis.
Zhang Y, Zhang J, Zhao Y, Zhang Y, Liu L, Xu X, Wang X, Fu J
Cell death & disease 2023 Nov 6;14(11):721
Cell death & disease 2023 Nov 6;14(11):721
The yeast prion protein Sup35 initiates α-synuclein pathology in mouse models of Parkinson's disease.
Meng L, Liu C, Li Y, Chen G, Xiong M, Yu T, Pan L, Zhang X, Zhou L, Guo T, Yuan X, Liu C, Zhang Z, Zhang Z
Science advances 2023 Nov 3;9(44):eadj1092
Science advances 2023 Nov 3;9(44):eadj1092
The yeast protein Ure2p triggers Tau pathology in a mouse model of tauopathy.
Meng L, Liu C, Liu M, Chen J, Liu C, Zhang Z, Chen G, Zhang Z
Cell reports 2023 Nov 28;42(11):113342
Cell reports 2023 Nov 28;42(11):113342
Inhibition of RhoA/ROCK signalling pathway activity improves neural damage and cognitive deficits in the fluorosis model.
Lingli C, Hongmei N, Penghuan J, Hongli Z, Yuye L, Rui W, Fei R, Zhihong Y, Dongfang H, Yaming G
Ecotoxicology and environmental safety 2023 Nov 1;266:115554
Ecotoxicology and environmental safety 2023 Nov 1;266:115554
Bone marrow mesenchymal stem cells and exercise restore motor function following spinal cord injury by activating PI3K/AKT/mTOR pathway.
Sun X, Huang LY, Pan HX, Li LJ, Wang L, Pei GQ, Wang Y, Zhang Q, Cheng HX, He CQ, Wei Q
Neural regeneration research 2023 May;18(5):1067-1075
Neural regeneration research 2023 May;18(5):1067-1075
Integrin β1/FAK/SRC signal pathway is involved in autism spectrum disorder in Tspan7 knockout rats.
Pang S, Luo Z, Dong W, Gao S, Chen W, Liu N, Zhang X, Gao X, Li J, Gao K, Shi X, Guan F, Zhang L, Zhang L
Life science alliance 2023 Mar;6(3)
Life science alliance 2023 Mar;6(3)
Bilirubin Induces A1-Like Reactivity of Astrocyte.
Li S, Huang H, Zhang Y, Li L, Hua Z
Neurochemical research 2023 Mar;48(3):804-815
Neurochemical research 2023 Mar;48(3):804-815
Kynurenic acid blunts A1 astrocyte activation against neurodegeneration in HIV-associated neurocognitive disorders.
Lun J, Li Y, Gao X, Gong Z, Chen X, Zou J, Zhou C, Huang Y, Zhou B, Huang P, Cao H
Journal of neuroinflammation 2023 Mar 30;20(1):87
Journal of neuroinflammation 2023 Mar 30;20(1):87
Prenatal alcohol exposure enhanced alcohol preference and susceptibility to PTSD in a sex-dependent manner through the synaptic HCN1 channel.
Yao H, Wang C, Xia Z
Journal of affective disorders 2023 Mar 1;324:143-152
Journal of affective disorders 2023 Mar 1;324:143-152
Polydatin Alleviates Chronic Stress-Induced Depressive and Anxiety-like Behaviors in a Mouse Model.
Wang J, Men Y, Wang Z
ACS chemical neuroscience 2023 Mar 1;14(5):977-987
ACS chemical neuroscience 2023 Mar 1;14(5):977-987
Magnify is a universal molecular anchoring strategy for expansion microscopy.
Klimas A, Gallagher BR, Wijesekara P, Fekir S, DiBernardo EF, Cheng Z, Stolz DB, Cambi F, Watkins SC, Brody SL, Horani A, Barth AL, Moore CI, Ren X, Zhao Y
Nature biotechnology 2023 Jun;41(6):858-869
Nature biotechnology 2023 Jun;41(6):858-869
Exposure to bisphenol A induces neurotoxicity associated with synaptic and cytoskeletal dysfunction in neuro-2a cells.
Wang S, Ning H, Wang X, Chen L, Hua L, Ren F, Hu D, Li R, Ma Z, Ge Y, Yin Z
Toxicology and industrial health 2023 Jun;39(6):325-335
Toxicology and industrial health 2023 Jun;39(6):325-335
Effect of Aging and a Dual Orexin Receptor Antagonist on Sleep Architecture and Non-REM Oscillations Including an REM Behavior Disorder Phenotype in the PS19 Mouse Model of Tauopathy.
Kam K, Vetter K, Tejiram RA, Pettibone WD, Shim K, Audrain M, Yu L, Daehn IS, Ehrlich ME, Varga AW
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Jun 21;43(25):4738-4749
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Jun 21;43(25):4738-4749
Gut Microbiota Taxon-Dependent Transformation of Microglial M1/M2 Phenotypes Underlying Mechanisms of Spatial Learning and Memory Impairment after Chronic Methamphetamine Exposure.
Wu Y, Dong Z, Jiang X, Qu L, Zhou W, Sun X, Hou J, Xu H, Cheng M
Microbiology spectrum 2023 Jun 15;11(3):e0030223
Microbiology spectrum 2023 Jun 15;11(3):e0030223
Islet amyloid polypeptide triggers α-synuclein pathology in Parkinson's disease.
Meng L, Li Y, Liu C, Zhang G, Chen J, Xiong M, Pan L, Zhang X, Chen G, Xiong J, Liu C, Xu X, Bu L, Zhang Z, Zhang Z
Progress in neurobiology 2023 Jul;226:102462
Progress in neurobiology 2023 Jul;226:102462
SIRT3 ameliorates diabetes-associated cognitive dysfunction via regulating mitochondria-associated ER membranes.
Chang Y, Wang C, Zhu J, Zheng S, Sun S, Wu Y, Jiang X, Li L, Ma R, Li G
Journal of translational medicine 2023 Jul 22;21(1):494
Journal of translational medicine 2023 Jul 22;21(1):494
FTO-dependent m(6)A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.
Li B, Xi W, Bai Y, Liu X, Zhang Y, Li L, Bian L, Liu C, Tang Y, Shen L, Yang L, Gu X, Xie J, Zhou Z, Wang Y, Yu X, Wang J, Chao J, Han B, Yao H
Nature communications 2023 Jan 30;14(1):489
Nature communications 2023 Jan 30;14(1):489
Atmospheric particulate matter impairs cognition by modulating synaptic function via the nose-to-brain route.
Liang C, Jiang Y, Zhang T, Ji Y, Zhang Y, Sun Y, Li S, Qi Y, Wang Y, Cai Y, Lai T, Cui L
The Science of the total environment 2023 Jan 20;857(Pt 3):159600
The Science of the total environment 2023 Jan 20;857(Pt 3):159600
Tunicamycin induces depression-like behaviors in male rats, accompanied by initiated chaperon-mediated autophagy and decreased synaptic protein expression in the hippocampus.
Yuan G, Xiao L, Xie Y, Si L, Xu H, Xu W, Wang G
Neuroscience letters 2023 Feb 28;798:137058
Neuroscience letters 2023 Feb 28;798:137058
Infralimbic YTHDF1 is necessary for the beneficial effects of acute mild exercise on auditory fear extinction retention.
Li SJ, Zhang LX, Zou GJ, Ma MH, Zhou SF, Lu XY, Li F, Li CQ
Cerebral cortex (New York, N.Y. : 1991) 2023 Feb 20;33(5):1814-1825
Cerebral cortex (New York, N.Y. : 1991) 2023 Feb 20;33(5):1814-1825
Copper Induces Cognitive Impairment in Mice via Modulation of Cuproptosis and CREB Signaling.
Zhang Y, Zhou Q, Lu L, Su Y, Shi W, Zhang H, Liu R, Pu Y, Yin L
Nutrients 2023 Feb 15;15(4)
Nutrients 2023 Feb 15;15(4)
Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage.
Wei Y, Miao Q, Zhang Q, Mao S, Li M, Xu X, Xia X, Wei K, Fan Y, Zheng X, Fang Y, Mei M, Zhang Q, Ding J, Fan Y, Lu M, Hu G
Nature neuroscience 2023 Dec;26(12):2081-2089
Nature neuroscience 2023 Dec;26(12):2081-2089
Ginsenoside Rb1 protects hippocampal neurons in depressed rats based on mitophagy-regulated astrocytic pyroptosis.
Li Y, Li J, Yang L, Ren F, Dong K, Zhao Z, Duan W, Wei W, Guo R
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155083
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155083
Extracellular vesicles from hiPSC-NSCs can prevent peripheral inflammation-induced cognitive dysfunction with inflammasome inhibition and improved neurogenesis in the hippocampus.
Ayyubova G, Kodali M, Upadhya R, Madhu LN, Attaluri S, Somayaji Y, Shuai B, Rao S, Shankar G, Shetty AK
Journal of neuroinflammation 2023 Dec 12;20(1):297
Journal of neuroinflammation 2023 Dec 12;20(1):297
Gypenoside IX restores Akt/GSK-3β pathway and alleviates Alzheimer's disease-like neuropathology and cognitive deficits.
Lei L, Luo Y, Kang D, Yang F, Meng D, Wang JZ, Liu R, Wang X, Li HL
Aging 2023 Dec 12;15(23):14172-14191
Aging 2023 Dec 12;15(23):14172-14191
Homocysteine impedes neurite outgrowth recovery after intracerebral haemorrhage by downregulating pCAMK2A.
Guo G, Yang J, Guo W, Deng H, Yu H, Bai S, Li G, Tang Y, Zhang P, Xu Y, Pan C, Tang Z
Stroke and vascular neurology 2023 Aug;8(4):335-348
Stroke and vascular neurology 2023 Aug;8(4):335-348
Sirt1 Overexpression Inhibits Fibrous Scar Formation and Improves Functional Recovery After Cerebral Ischemic Injury Through the Deacetylation of 14-3-3ζ.
Chen Y, Huang J, Liu J, Zhu H, Li X, Wen J, Tian M, Ren J, Zhou L, Yang Q
Molecular neurobiology 2023 Aug;60(8):4795-4810
Molecular neurobiology 2023 Aug;60(8):4795-4810
CNTN1 in the Nucleus Accumbens is Involved in Methamphetamine-Induced Conditioned Place Preference in Mice.
Zhang L, Zeng Z, Lu X, Li M, Yao J, Zou G, Chen Z, Li Q, Li C, Li F
Neurotoxicity research 2023 Aug;41(4):324-337
Neurotoxicity research 2023 Aug;41(4):324-337
The microglial innate immune receptors TREM-1 and TREM-2 in the anterior cingulate cortex (ACC) drive visceral hypersensitivity and depressive-like behaviors following DSS-induced colitis.
Wu K, Liu YY, Shao S, Song W, Chen XH, Dong YT, Zhang YM
Brain, behavior, and immunity 2023 Aug;112:96-117
Brain, behavior, and immunity 2023 Aug;112:96-117
The effects of acupuncture on depression by regulating BDNF-related balance via lateral habenular nucleus BDNF/TrkB/CREB signaling pathway in rats.
Tong T, Chen Y, Hao C, Shen J, Chen W, Cheng W, Yan S, Li J, Li Y, Gulizhaerkezi T, Zeng J, Meng X
Behavioural brain research 2023 Aug 5;451:114509
Behavioural brain research 2023 Aug 5;451:114509
Aerobic Exercise Facilitates the Nuclear Translocation of SREBP2 by Activating AKT/SEC24D to Contribute Cholesterol Homeostasis for Improving Cognition in APP/PS1 Mice.
Hu Z, Yuan Y, Tong Z, Liao M, Yuan S, Wu W, Tang Y, Wang Y, Tang C, Liu W
International journal of molecular sciences 2023 Aug 16;24(16)
International journal of molecular sciences 2023 Aug 16;24(16)
A terrified-sound stress causes cognitive impairment in female mice by impairing neuronal plasticity.
Gao S, Zhang L, Wang X, Li R, Han L, Xiong X, Jiang Q, Cheng D, Xiao X, Li H, Yang J
Brain research 2023 Aug 1;1812:148419
Brain research 2023 Aug 1;1812:148419
Corticostriatal Projections Relying on GABA Levels Mediate Exercise-Induced Functional Recovery in Cerebral Ischemic Mice.
Xing Y, Zhang A, Li C, Han J, Wang J, Luo L, Chang X, Tian Z, Bai Y
Molecular neurobiology 2023 Apr;60(4):1836-1853
Molecular neurobiology 2023 Apr;60(4):1836-1853
Thymol improves autism-like behaviour in VPA-induced ASD rats through the Pin1/p38 MAPK pathway.
Xiong Y, Chen J, Lv M, Wang F, Zhang H, Tang B, Li Y
International immunopharmacology 2023 Apr;117:109885
International immunopharmacology 2023 Apr;117:109885
miR-6315 silencing protects against spinal cord injury through the Smo and anti-ferroptosis pathway.
Ma Z, Fan Y, Peng Y, Bian L, Zhou J, Wang L, Xia Y, Zheng S, Ji Y, Han Y, Feng C, Ba Y
Bioscience reports 2023 Apr 26;43(4)
Bioscience reports 2023 Apr 26;43(4)
Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix.
Nigro P, Vamvini M, Yang J, Caputo T, Ho LL, Carbone NP, Papadopoulos D, Conlin R, He J, Hirshman MF, White JD, Robidoux J, Hickner RC, Nielsen S, Pedersen BK, Kellis M, Middelbeek RJW, Goodyear LJ
Cell reports 2023 Apr 25;42(4):112392
Cell reports 2023 Apr 25;42(4):112392
The role of reactive astrocytes in neurotoxicity induced by ultrafine particulate matter.
Li B, Chang X, Liang X, Liu T, Shen Y, Zhang Q, Yang X, Lyu Y, Liu L, Guo J, Wu M, Gao Y, Yan X, Wang T, Zhang W, Qiu Y, Zheng J
The Science of the total environment 2023 Apr 1;867:161416
The Science of the total environment 2023 Apr 1;867:161416
Peripheral Transplantation of Mesenchymal Stem Cells at Sepsis Convalescence Improves Cognitive Function of Sepsis Surviving Mice.
Tan L, Cheng Y, Wang H, Tong J, Qin X
Oxidative medicine and cellular longevity 2022;2022:6897765
Oxidative medicine and cellular longevity 2022;2022:6897765
Treatment Combining Focused Ultrasound with Gastrodin Alleviates Memory Deficit and Neuropathology in an Alzheimer's Disease-Like Experimental Mouse Model.
Luo K, Wang Y, Chen WS, Feng X, Liao Y, Chen S, Liu Y, Liao C, Chen M, Ao L
Neural plasticity 2022;2022:5241449
Neural plasticity 2022;2022:5241449
Protective effect of microorganism biotransformation-produced resveratrol on the high fat diet-induced hyperlipidemia, hepatic steatosis and synaptic impairment in hamsters.
Su CH, Wang HL, Tsai ML, Lin YC, Liao JM, Yen CC, Ting HC, Yu CH
International journal of medical sciences 2022;19(10):1586-1595
International journal of medical sciences 2022;19(10):1586-1595
Young plasma reverses anesthesia and surgery-induced cognitive impairment in aged rats by modulating hippocampal synaptic plasticity.
Li Y, Zhang Q, Yan W, Wang X, Yu J, Yin C, Zhou Q, Hou Z, Wang Q
Frontiers in aging neuroscience 2022;14:996223
Frontiers in aging neuroscience 2022;14:996223
Confinement induces oxidative damage and synaptic dysfunction in mice.
Li N, Wang H, Xin S, Min R, Zhang Y, Deng Y
Frontiers in physiology 2022;13:999574
Frontiers in physiology 2022;13:999574
Hippocampal Iron Accumulation Impairs Synapses and Memory via Suppressing Furin Expression and Downregulating BDNF Maturation.
Zhang Y, Bai X, Zhang Y, Yao S, Cui Y, You LH, Yu P, Chang YZ, Gao G
Molecular neurobiology 2022 Sep;59(9):5574-5590
Molecular neurobiology 2022 Sep;59(9):5574-5590
RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission.
Ma P, Wan LP, Li Y, He CH, Song NN, Zhao S, Wang H, Ding YQ, Mao B, Sheng N
Science advances 2022 Sep 30;8(39):eabq4736
Science advances 2022 Sep 30;8(39):eabq4736
Combined cell grafting and VPA administration facilitates neural repair through axonal regeneration and synaptogenesis in traumatic brain injury.
Liu S, Tian H, Niu Y, Yu C, Xie L, Jin Z, Niu W, Ren J, Fu L, Yao Z
Acta biochimica et biophysica Sinica 2022 Sep 25;54(9):1289-1300
Acta biochimica et biophysica Sinica 2022 Sep 25;54(9):1289-1300
Profile of chimeric RNAs and TMPRSS2-ERG e2e4 isoform in neuroendocrine prostate cancer.
Wang Q, Chen J, Singh S, Xie Z, Qin F, Shi X, Cornelison R, Li H, Huang H
Cell & bioscience 2022 Sep 10;12(1):153
Cell & bioscience 2022 Sep 10;12(1):153
Evaluation of Neurotoxicity in BALB/c Mice following Chronic Exposure to Polystyrene Microplastics.
Jin H, Yang C, Jiang C, Li L, Pan M, Li D, Han X, Ding J
Environmental health perspectives 2022 Oct;130(10):107002
Environmental health perspectives 2022 Oct;130(10):107002
Chrysin alleviates lipopolysaccharide-induced neuron damage and behavioral deficits in mice through inhibition of Fyn.
Wang Q, Yang Z, Wu X, Zhang X, Geng F, Wang Q, Geng Z, Yu C, Li Z
International immunopharmacology 2022 Oct;111:109118
International immunopharmacology 2022 Oct;111:109118
Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like mice.
Li S, Fang Y, Zhang Y, Song M, Zhang X, Ding X, Yao H, Chen M, Sun Y, Ding J, Wang Q, Lu M, Wu G, Hu G
Cell reports 2022 Oct 25;41(4):111532
Cell reports 2022 Oct 25;41(4):111532
Dietary Salt Disrupts Tricarboxylic Acid Cycle and Induces Tau Hyperphosphorylation and Synapse Dysfunction during Aging.
Yuan M, Wang Y, Wen J, Jing F, Zou Q, Pu Y, Pan T, Cai Z
Aging and disease 2022 Oct 1;13(5):1532-1545
Aging and disease 2022 Oct 1;13(5):1532-1545
Fast resupply of synaptic vesicles requires synaptotagmin-3.
Weingarten DJ, Shrestha A, Juda-Nelson K, Kissiwaa SA, Spruston E, Jackman SL
Nature 2022 Nov;611(7935):320-325
Nature 2022 Nov;611(7935):320-325
Differential Expression of Secretogranins II and III in Canine Adrenal Chromaffin Cells and Pheochromocytomas.
Gomi H, Nagumo T, Asano K, Konosu M, Yasui T, Torii S, Hosaka M
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2022 May;70(5):335-356
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2022 May;70(5):335-356
A synapsin Ⅰ cleavage fragment contributes to synaptic dysfunction in Alzheimer's disease.
Meng L, Zou L, Xiong M, Chen J, Zhang X, Yu T, Li Y, Liu C, Chen G, Wang Z, Ye K, Zhang Z
Aging cell 2022 May;21(5):e13619
Aging cell 2022 May;21(5):e13619
m6A and YTHDF proteins contribute to the localization of select neuronal mRNAs.
Flamand MN, Meyer KD
Nucleic acids research 2022 May 6;50(8):4464-4483
Nucleic acids research 2022 May 6;50(8):4464-4483
Exercise-induced neuroprotection against cerebral ischemia/reperfusion injury is mediated via alleviating inflammasome-induced pyroptosis.
Liu MX, Luo L, Fu JH, He JY, Chen MY, He ZJ, Jia J
Experimental neurology 2022 Mar;349:113952
Experimental neurology 2022 Mar;349:113952
Progranulin improves neural development via the PI3K/Akt/GSK-3β pathway in the cerebellum of a VPA-induced rat model of ASD.
Wang L, Chen J, Hu Y, Liao A, Zheng W, Wang X, Lan J, Shen J, Wang S, Yang F, Wang Y, Li Y, Chen D
Translational psychiatry 2022 Mar 22;12(1):114
Translational psychiatry 2022 Mar 22;12(1):114
Heatstroke-induced late-onset neurological deficits in mice caused by white matter demyelination, Purkinje cell degeneration, and synaptic impairment in the cerebellum.
Miyamoto K, Nakamura M, Ohtaki H, Suzuki K, Yamaga H, Yanagisawa K, Maeda A, Yagi M, Hayashi M, Honda K, Dohi K
Scientific reports 2022 Jun 22;12(1):10598
Scientific reports 2022 Jun 22;12(1):10598
Proteomic analysis of the effects of caffeine in a neonatal rat model of hypoxic-ischemic white matter damage.
Yang L, Yu X, Zhang Y, Liu N, Li D, Xue X, Fu J
CNS neuroscience & therapeutics 2022 Jul;28(7):1019-1032
CNS neuroscience & therapeutics 2022 Jul;28(7):1019-1032
Transient neuroinflammation following surgery contributes to long-lasting cognitive decline in elderly rats via dysfunction of synaptic NMDA receptor.
Chen B, Qin G, Xiao J, Deng X, Lin A, Liu H
Journal of neuroinflammation 2022 Jul 13;19(1):181
Journal of neuroinflammation 2022 Jul 13;19(1):181
Gestational exposure to fluoride impairs cognition in C57 BL/6 J male offspring mice via the p-Creb1-BDNF-TrkB signaling pathway.
Li W, Lu L, Zhu D, Liu J, Shi Y, Zeng H, Yu X, Guo J, Wei B, Cai Y, Sun M
Ecotoxicology and environmental safety 2022 Jul 1;239:113682
Ecotoxicology and environmental safety 2022 Jul 1;239:113682
DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors.
Chen P, Liu Z, Zhang Q, Lin D, Song L, Liu J, Jiao HF, Lai X, Zou S, Wang S, Zhou T, Li BM, Zhu L, Pan BX, Fei E
The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 Jan 26;42(4):532-551
The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 Jan 26;42(4):532-551
The circRNA circ-Nbea participates in regulating diabetic encephalopathy.
Liu J, Deng Z, Yu Z, Zhou W, Yuan Q
Brain research 2022 Jan 1;1774:147702
Brain research 2022 Jan 1;1774:147702
Liraglutide Alleviates Cognitive Deficit in db/db Mice: Involvement in Oxidative Stress, Iron Overload, and Ferroptosis.
An JR, Su JN, Sun GY, Wang QF, Fan YD, Jiang N, Yang YF, Shi Y
Neurochemical research 2022 Feb;47(2):279-294
Neurochemical research 2022 Feb;47(2):279-294
Polygonatum sibiricum ameliorated cognitive impairment of naturally aging rats through BDNF-TrkB signaling pathway.
Zhang X, Ni L, Hu S, Yue B, Chen X, Yuan D, Wang T, Zhou Z
Journal of food biochemistry 2022 Dec;46(12):e14510
Journal of food biochemistry 2022 Dec;46(12):e14510
Effects of neuron autophagy induced by arsenic and fluoride on spatial learning and memory in offspring rats.
Zhao Q, Pan W, Li J, Yu S, Liu Y, Zhang X, Qu R, Zhang Q, Li B, Yan X, Ren X, Qiu Y
Chemosphere 2022 Dec;308(Pt 2):136341
Chemosphere 2022 Dec;308(Pt 2):136341
Heat shock protein Hspa13 regulates endoplasmic reticulum and cytosolic proteostasis through modulation of protein translocation.
Espinoza MF, Nguyen KK, Sycks MM, Lyu Z, Quanrud GM, Montoya MR, Genereux JC
The Journal of biological chemistry 2022 Dec;298(12):102597
The Journal of biological chemistry 2022 Dec;298(12):102597
Inhibition of BRD4 decreases fibrous scarring after ischemic stroke in rats by inhibiting the phosphorylation of Smad2/3.
Li X, Zhu H, Wen J, Huang J, Chen Y, Tian M, Ren J, Zhou L, Yang Q
Brain research 2022 Dec 15;1797:148126
Brain research 2022 Dec 15;1797:148126
FOXO3 Regulates Sevoflurane-Induced Neural Stem Cell Differentiation in Fetal Rats.
Li X, Jiang X, Gao Q, Zhao P
Cellular and molecular neurobiology 2022 Aug;42(6):1777-1786
Cellular and molecular neurobiology 2022 Aug;42(6):1777-1786
Acute lead acetate induces neurotoxicity through decreased synaptic plasticity-related protein expression and disordered dendritic formation in nerve cells.
Chen L, Liu Y, Jia P, Zhang H, Yin Z, Hu D, Ning H, Ge Y
Environmental science and pollution research international 2022 Aug;29(39):58927-58935
Environmental science and pollution research international 2022 Aug;29(39):58927-58935
Identification of distinct genomic features reveals frequent somatic AHNAK and PTEN mutations predominantly in primary malignant melanoma presenting in the ureter.
Huang Y, Wei L, Huang Y, Wen S, Liu T, Duan X, Wang Y, Zhang H, Fan B, Hu B
Japanese journal of clinical oncology 2022 Aug 5;52(8):930-943
Japanese journal of clinical oncology 2022 Aug 5;52(8):930-943
Traumatic Brain Injury Accelerates the Onset of Cognitive Dysfunction and Aggravates Alzheimer's-Like Pathology in the Hippocampus by Altering the Phenotype of Microglia in the APP/PS1 Mouse Model.
Wu D, Kumal JPP, Lu X, Li Y, Mao D, Tang X, Nie M, Liu X, Sun L, Liu B, Zhang Y
Frontiers in neurology 2021;12:666430
Frontiers in neurology 2021;12:666430
Nicotinamide Improves Cognitive Function in Mice With Chronic Cerebral Hypoperfusion.
Liu B, Zhao G, Jin L, Shi J
Frontiers in neurology 2021;12:596641
Frontiers in neurology 2021;12:596641
Postconditioning with Sevoflurane or Propofol Alleviates Lipopolysaccharide-Induced Neuroinflammation but Exerts Dissimilar Effects on the NR2B Subunit and Cognition.
Liu H, Chen B, Guo B, Deng X, Wang B, Dou X
Molecular neurobiology 2021 Sep;58(9):4251-4267
Molecular neurobiology 2021 Sep;58(9):4251-4267
Abnormal spatiotemporal expression pattern of progranulin and neurodevelopment impairment in VPA-induced ASD rat model.
Lan J, Hu Y, Wang X, Zheng W, Liao A, Wang S, Li Y, Wang Y, Yang F, Chen D
Neuropharmacology 2021 Sep 15;196:108689
Neuropharmacology 2021 Sep 15;196:108689
YAP drives fate conversion and chemoresistance of small cell lung cancer.
Wu Q, Guo J, Liu Y, Zheng Q, Li X, Wu C, Fang D, Chen X, Ma L, Xu P, Xu X, Liao C, Wu M, Shen L, Song H
Science advances 2021 Oct;7(40):eabg1850
Science advances 2021 Oct;7(40):eabg1850
Neuroprotective effects of macamide from maca (Lepidium meyenii Walp.) on corticosterone-induced hippocampal impairments through its anti-inflammatory, neurotrophic, and synaptic protection properties.
Yu Z, Li D, Zhai S, Xu H, Liu H, Ao M, Zhao C, Jin W, Yu L
Food & function 2021 Oct 4;12(19):9211-9228
Food & function 2021 Oct 4;12(19):9211-9228
Iptakalim alleviates synaptic damages via targeting mitochondrial ATP-sensitive potassium channel in depression.
Guo W, Tang ZY, Cai ZY, Zhao WE, Yang J, Wang XP, Ji J, Huang XX, Sun XL
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21581
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21581
Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.
Li X, Zhang J, Li D, He C, He K, Xue T, Wan L, Zhang C, Liu Q
Neuron 2021 Mar 17;109(6):957-970.e8
Neuron 2021 Mar 17;109(6):957-970.e8
Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease.
Zou L, Zhang X, Xiong M, Meng L, Tian Y, Pan L, Yuan X, Chen G, Wang Z, Bu L, Yao Z, Zhang Z, Ye K, Zhang Z
Neurobiology of disease 2021 Jul;154:105326
Neurobiology of disease 2021 Jul;154:105326
Caloric restriction ameliorates high-fat diet induced cognitive deficits through attenuating neuroinflammation via the TREM2-PI3K/AKT signaling pathway.
Wang R, Zhou Z, Wang D, Zhao Q, Zhang C, Liu C, Zhao H, Yuan C, Yuan D, Wang T
Food & function 2021 Jul 21;12(14):6464-6478
Food & function 2021 Jul 21;12(14):6464-6478
Histone demethylase PHF8 drives neuroendocrine prostate cancer progression by epigenetically upregulating FOXA2.
Liu Q, Pang J, Wang LA, Huang Z, Xu J, Yang X, Xie Q, Huang Y, Tang T, Tong D, Liu G, Wang L, Zhang D, Ma Q, Xiao H, Lan W, Qin J, Jiang J
The Journal of pathology 2021 Jan;253(1):106-118
The Journal of pathology 2021 Jan;253(1):106-118
Hippocampal LASP1 ameliorates chronic stress-mediated behavioral responses in a mouse model of unpredictable chronic mild stress.
Cui YH, Fu A, Wang XQ, Tu BX, Chen KZ, Wang YK, Hu QG, Wang LF, Hu ZL, Pan PH, Li F, Bi FF, Li CQ
Neuropharmacology 2021 Feb 15;184:108410
Neuropharmacology 2021 Feb 15;184:108410
Enriched environment remedies cognitive dysfunctions and synaptic plasticity through NMDAR-Ca(2+)-Activin A circuit in chronic cerebral hypoperfusion rats.
Zhang X, Shi X, Wang J, Xu Z, He J
Aging 2021 Aug 30;13(16):20748-20761
Aging 2021 Aug 30;13(16):20748-20761
Haploinsufficiency of the TDP43 ubiquitin E3 ligase RNF220 leads to ALS-like motor neuron defects in the mouse.
Ma P, Li Y, Wang H, Mao B
Journal of molecular cell biology 2021 Aug 18;13(5):374-382
Journal of molecular cell biology 2021 Aug 18;13(5):374-382
Quantitative proteomic analysis of cortex in the depressive-like behavior of rats induced by the simulated complex space environment.
Min R, Chen Z, Wang Y, Deng Z, Zhang Y, Deng Y
Journal of proteomics 2021 Apr 15;237:104144
Journal of proteomics 2021 Apr 15;237:104144
Curcumin Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors via Restoring Changes in Oxidative Stress and the Activation of Nrf2 Signaling Pathway in Rats.
Liao D, Lv C, Cao L, Yao D, Wu Y, Long M, Liu N, Jiang P
Oxidative medicine and cellular longevity 2020;2020:9268083
Oxidative medicine and cellular longevity 2020;2020:9268083
Xiaoyao Pills Attenuate Inflammation and Nerve Injury Induced by Lipopolysaccharide in Hippocampal Neurons In Vitro.
Fang Y, Shi B, Liu X, Luo J, Rao Z, Liu R, Zeng N
Neural plasticity 2020;2020:8841332
Neural plasticity 2020;2020:8841332
Transplantation of Stem Cells from Human Exfoliated Deciduous Teeth Decreases Cognitive Impairment from Chronic Cerebral Ischemia by Reducing Neuronal Apoptosis in Rats.
Zhu S, Min D, Zeng J, Ju Y, Liu Y, Chen X
Stem cells international 2020;2020:6393075
Stem cells international 2020;2020:6393075
Bisphenol-A exposure induced neurotoxicity and associated with synapse and cytoskeleton in Neuro-2a cells.
Yin Z, Hua L, Chen L, Hu D, Li J, An Z, Tian T, Ning H, Ge Y
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104911
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104911
Identification and immunohistochemical characterization of G-quadruplexes in mouse brain.
Asamitsu S, Imai Y, Yabuki Y, Ikenoshita S, Takeuchi M, Kashiwagi H, Tanoue Y, Fukuda T, Shioda N
Biochemical and biophysical research communications 2020 Oct 8;531(1):67-74
Biochemical and biophysical research communications 2020 Oct 8;531(1):67-74
Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice.
Feng T, Mai S, Roscoe JM, Sheng RR, Ullah M, Zhang J, Katz II, Yu H, Xiong W, Hu F
EMBO reports 2020 Oct 5;21(10):e50219
EMBO reports 2020 Oct 5;21(10):e50219
The Neurotrophic Function of Glucagon-Like Peptide-1 Promotes Human Neuroblastoma Differentiation via the PI3K-AKT Axis.
Yang JL, Lin YT, Chen WY, Yang YR, Sun SF, Chen SD
Biology 2020 Oct 22;9(11)
Biology 2020 Oct 22;9(11)
Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells.
Sun Y, He L, Wang T, Hua W, Qin H, Wang J, Wang L, Gu W, Li T, Li N, Liu X, Chen F, Tang L
Molecular neurobiology 2020 Nov;57(11):4628-4641
Molecular neurobiology 2020 Nov;57(11):4628-4641
The critical role of the hippocampal NLRP3 inflammasome in social isolation-induced cognitive impairment in male mice.
Niu L, Luo SS, Xu Y, Wang Z, Luo D, Yang H, Li W, He J, Zhong XL, Liu ZH, Zeng JY, Cao WY, Wan W
Neurobiology of learning and memory 2020 Nov;175:107301
Neurobiology of learning and memory 2020 Nov;175:107301
NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.
He X, Yang W, Zeng Z, Wei Y, Gao J, Zhang B, Li L, Liu L, Wan Y, Zeng Q, Gong Z, Liu L, Zhang H, Li Y, Yang S, Hu T, Wu L, Masliah E, Huang S, Cao H
Cellular & molecular immunology 2020 Mar;17(3):283-299
Cellular & molecular immunology 2020 Mar;17(3):283-299
Small dose of L-dopa/Benserazide hydrochloride improved sepsis-induced neuroinflammation and long-term cognitive dysfunction in sepsis mice.
Li F, Zhang B, Duan S, Qing W, Tan L, Chen S, Wang Y, Li D, Yang J, Tong J, Fang J, Le Y
Brain research 2020 Jun 15;1737:146780
Brain research 2020 Jun 15;1737:146780
Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia.
An JR, Zhao YS, Luo LF, Guan P, Tan M, Ji ES
Life sciences 2020 Jun 1;250:117573
Life sciences 2020 Jun 1;250:117573
Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer's Disease Pathogenesis in Cell and Animal Models.
Wei H, Zhang HL, Wang XC, Xie JZ, An DD, Wan L, Wang JZ, Zeng Y, Shu XJ, Westermarck J, Lu YM, Ohlmeyer M, Liu R
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Jul;17(3):1087-1103
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Jul;17(3):1087-1103
Fingolimod (FTY720) improves postoperative cognitive dysfunction in mice subjected to D-galactose-induced aging.
Zhang J, Xiao B, Li CX, Wang Y
Neural regeneration research 2020 Jul;15(7):1308-1315
Neural regeneration research 2020 Jul;15(7):1308-1315
Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2.
Escande-Beillard N, Loh A, Saleem SN, Kanata K, Hashimoto Y, Altunoglu U, Metoska A, Grandjean J, Ng FM, Pomp O, Baburajendran N, Wong J, Hill J, Beillard E, Cozzone P, Zaki M, Kayserili H, Hamada H, Shiratori H, Reversade B
Neuron 2020 Jul 8;107(1):82-94.e6
Neuron 2020 Jul 8;107(1):82-94.e6
Cancer cell's neuroendocrine feature can be acquired through cell-cell fusion during cancer-neural stem cell interaction.
Yin L, Hu P, Shi X, Qian W, Zhau HE, Pandol SJ, Lewis MS, Chung LWK, Wang R
Scientific reports 2020 Jan 27;10(1):1216
Scientific reports 2020 Jan 27;10(1):1216
Cryopreservation of a Human Brain and Its Experimental Correlate in Rats.
Canatelli-Mallat M, Lascaray F, Entraigues-Abramson M, Portiansky EL, Blamaceda N, Morel GR, Goya RG
Rejuvenation research 2020 Dec;23(6):516-525
Rejuvenation research 2020 Dec;23(6):516-525
Corticosterone Induced the Increase of proBDNF in Primary Hippocampal Neurons Via Endoplasmic Reticulum Stress.
Liu Y, Zou GJ, Tu BX, Hu ZL, Luo C, Cui YH, Xu Y, Li F, Dai RP, Bi FF, Li CQ
Neurotoxicity research 2020 Aug;38(2):370-384
Neurotoxicity research 2020 Aug;38(2):370-384
Subcutaneous administration of β-hydroxybutyrate improves learning and memory of sepsis surviving mice.
Wang X, Song Y, Chen J, Zhang S, Le Y, Xie Z, Ouyang W, Tong J
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Apr;17(2):616-626
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Apr;17(2):616-626
Xiaoyao Pills Prevent Lipopolysaccharide-Induced Depression by Inhibiting Inflammation and Protecting Nerves.
Shi B, Luo J, Fang Y, Liu X, Rao Z, Liu R, Zeng N
Frontiers in pharmacology 2019;10:1324
Frontiers in pharmacology 2019;10:1324
MicroRNA-99a is a Potential Target for Regulating Hypothalamic Synaptic Plasticity in the Peri/Postmenopausal Depression Model.
Yang J, Zhang L, Cao LL, Qi J, Li P, Wang XP, Sun XL
Cells 2019 Sep 13;8(9)
Cells 2019 Sep 13;8(9)
Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer's disease.
Zhou C, Sun X, Hu Y, Song J, Dong S, Kong D, Wang Y, Hua X, Han J, Zhou Y, Jin G, Yang X, Shi H, Zhang Z, Hua F
Aging 2019 Sep 11;11(17):7257-7273
Aging 2019 Sep 11;11(17):7257-7273
Neuroprotective effects of a Smoothened receptor agonist against postoperative cognitive dysfunction by promoting autophagy in the dentate gyrus of aged rats.
Li PJ, Guo YQ, Ding PY, Liu RB, Deng F, Feng XX, Yan WJ
Neurological research 2019 Oct;41(10):867-874
Neurological research 2019 Oct;41(10):867-874
Cinnamic acid rescues behavioral deficits in a mouse model of traumatic brain injury by targeting miR-455-3p/HDAC2.
Guo S, Zhen Y, Zhu Z, Zhou G, Zheng X
Life sciences 2019 Oct 15;235:116819
Life sciences 2019 Oct 15;235:116819
SMCR8 negatively regulates AKT and MTORC1 signaling to modulate lysosome biogenesis and tissue homeostasis.
Lan Y, Sullivan PM, Hu F
Autophagy 2019 May;15(5):871-885
Autophagy 2019 May;15(5):871-885
Absence of BBSome function leads to astrocyte reactivity in the brain.
Singh M, Garrison JE, Wang K, Sheffield VC
Molecular brain 2019 May 9;12(1):48
Molecular brain 2019 May 9;12(1):48
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
Shah SZA, Zhao D, Taglialatela G, Hussain T, Dong H, Sabir N, Mangi MH, Wu W, Lai M, Zhang X, Duan Y, Wang L, Zhou X, Yang L
International journal of molecular sciences 2019 Mar 6;20(5)
International journal of molecular sciences 2019 Mar 6;20(5)
SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE.
Raihan O, Brishti A, Li Q, Zhang Q, Li D, Li X, Zhang Q, Xie Z, Li J, Zhang J, Liu Q
Cell reports 2019 Jul 2;28(1):78-90.e6
Cell reports 2019 Jul 2;28(1):78-90.e6
Chronic fluoride exposure induces neuronal apoptosis and impairs neurogenesis and synaptic plasticity: Role of GSK-3β/β-catenin pathway.
Jiang P, Li G, Zhou X, Wang C, Qiao Y, Liao D, Shi D
Chemosphere 2019 Jan;214:430-435
Chemosphere 2019 Jan;214:430-435
PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by influencing synaptic function in the primary motor cortex of rats.
Mo J, Wang B, Zhu X, Wu X, Liu Y
Neurobiology of disease 2019 Jan;121:274-285
Neurobiology of disease 2019 Jan;121:274-285
A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets.
Sharon N, Chawla R, Mueller J, Vanderhooft J, Whitehorn LJ, Rosenthal B, Gürtler M, Estanboulieh RR, Shvartsman D, Gifford DK, Trapnell C, Melton D
Cell 2019 Feb 7;176(4):790-804.e13
Cell 2019 Feb 7;176(4):790-804.e13
Cadmium induces actin cytoskeleton alterations and dysfunction in Neuro-2a cells.
Ge Y, Song X, Chen L, Hu D, Hua L, Cui Y, Liu J, An Z, Yin Z, Ning H
Environmental toxicology 2019 Apr;34(4):469-475
Environmental toxicology 2019 Apr;34(4):469-475
Brain-Derived Neurotrophic Factor Precursor in the Hippocampus Regulates Both Depressive and Anxiety-Like Behaviors in Rats.
Zhong F, Liu L, Wei JL, Hu ZL, Li L, Wang S, Xu JM, Zhou XF, Li CQ, Yang ZY, Dai RP
Frontiers in psychiatry 2018;9:776
Frontiers in psychiatry 2018;9:776
Mesenchymal Stem Cell-Derived Exosomes Reduce A1 Astrocytes via Downregulation of Phosphorylated NFκB P65 Subunit in Spinal Cord Injury.
Wang L, Pei S, Han L, Guo B, Li Y, Duan R, Yao Y, Xue B, Chen X, Jia Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(4):1535-1559
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(4):1535-1559
Metformin Inhibits Prostate Cancer Progression by Targeting Tumor-Associated Inflammatory Infiltration.
Liu Q, Tong D, Liu G, Gao J, Wang LA, Xu J, Yang X, Xie Q, Huang Y, Pang J, Wang L, He Y, Zhang D, Ma Q, Lan W, Jiang J
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Nov 15;24(22):5622-5634
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Nov 15;24(22):5622-5634
Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury.
Ying Z, Pan C, Shao T, Liu L, Li L, Guo D, Zhang S, Yuan T, Cao R, Jiang Z, Chen S, Wang F, Wang X
Molecular cell 2018 Nov 1;72(3):457-468.e5
Molecular cell 2018 Nov 1;72(3):457-468.e5
Rodent Neural Progenitor Cells Support Functional Recovery after Cervical Spinal Cord Contusion.
Brock JH, Graham L, Staufenberg E, Im S, Tuszynski MH
Journal of neurotrauma 2018 May 1;35(9):1069-1078
Journal of neurotrauma 2018 May 1;35(9):1069-1078
Pin1 mediates Aβ(42)-induced dendritic spine loss.
Stallings NR, O'Neal MA, Hu J, Kavalali ET, Bezprozvanny I, Malter JS
Science signaling 2018 Mar 20;11(522)
Science signaling 2018 Mar 20;11(522)
Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease.
Reddy PH, Yin X, Manczak M, Kumar S, Pradeepkiran JA, Vijayan M, Reddy AP
Human molecular genetics 2018 Jul 15;27(14):2502-2516
Human molecular genetics 2018 Jul 15;27(14):2502-2516
Quantitative proteomics study of host response to virulent and attenuated pseudorabies virus infection in mouse brain.
Zeng HL, Yu FL, Zhang Z, Yang Q, Jin S, He X, Chen X, Shen Y, Cheng L, Guo L, Xu F
Biochimica et biophysica acta. Proteins and proteomics 2018 Feb;1866(2):307-315
Biochimica et biophysica acta. Proteins and proteomics 2018 Feb;1866(2):307-315
Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury.
Zhu L, Tang T, Fan R, Luo JK, Cui HJ, Zhang CH, Peng WJ, Sun P, Xiong XG, Wang Y
Neural regeneration research 2018 Aug;13(8):1417-1424
Neural regeneration research 2018 Aug;13(8):1417-1424
Pre-existing weakness is critical for the occurrence of postoperative cognitive dysfunction in mice of the same age.
Tang Y, Wang X, Zhang S, Duan S, Qing W, Chen G, Ye F, Le Y, Ouyang W
PloS one 2017;12(8):e0182471
PloS one 2017;12(8):e0182471
Sepsis-induced selective loss of NMDA receptors modulates hippocampal neuropathology in surviving septic mice.
Zhang S, Wang X, Ai S, Ouyang W, Le Y, Tong J
PloS one 2017;12(11):e0188273
PloS one 2017;12(11):e0188273
Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models.
Song Z, Shah SZA, Yang W, Dong H, Yang L, Zhou X, Zhao D
Frontiers in molecular neuroscience 2017;10:128
Frontiers in molecular neuroscience 2017;10:128
Aqua-soluble DDQ reduces the levels of Drp1 and Aβ and inhibits abnormal interactions between Aβ and Drp1 and protects Alzheimer's disease neurons from Aβ- and Drp1-induced mitochondrial and synaptic toxicities.
Kuruva CS, Manczak M, Yin X, Ogunmokun G, Reddy AP, Reddy PH
Human molecular genetics 2017 Sep 1;26(17):3375-3395
Human molecular genetics 2017 Sep 1;26(17):3375-3395
The effects of fluoride on neuronal function occurs via cytoskeleton damage and decreased signal transmission.
Chen L, Ning H, Yin Z, Song X, Feng Y, Qin H, Li Y, Wang J, Ge Y, Wang W
Chemosphere 2017 Oct;185:589-594
Chemosphere 2017 Oct;185:589-594
Chronic administration of parecoxib exerts anxiolytic-like and memory enhancing effects and modulates synaptophysin expression in mice.
Wang B, Jin X, Kuang X, Tian S
BMC anesthesiology 2017 Nov 13;17(1):152
BMC anesthesiology 2017 Nov 13;17(1):152
Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters.
Shah SZA, Zhao D, Taglialatela G, Khan SH, Hussain T, Dong H, Lai M, Zhou X, Yang L
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2017 Apr;14(2):463-483
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2017 Apr;14(2):463-483
Identification of TMEM230 mutations in familial Parkinson's disease.
Deng HX, Shi Y, Yang Y, Ahmeti KB, Miller N, Huang C, Cheng L, Zhai H, Deng S, Nuytemans K, Corbett NJ, Kim MJ, Deng H, Tang B, Yang Z, Xu Y, Chan P, Huang B, Gao XP, Song Z, Liu Z, Fecto F, Siddique N, Foroud T, Jankovic J, Ghetti B, Nicholson DA, Krainc D, Melen O, Vance JM, Pericak-Vance MA, Ma YC, Rajput AH, Siddique T
Nature genetics 2016 Jul;48(7):733-9
Nature genetics 2016 Jul;48(7):733-9
Identification of protein network alterations upon retinal ischemia-reperfusion injury by quantitative proteomics using a Rattus norvegicus model.
Tian H, Wang L, Cai R, Zheng L, Guo L
PloS one 2014;9(12):e116453
PloS one 2014;9(12):e116453
Effect of treadmill exercise on 5-HT, 5-HT1A receptor and brain derived neurophic factor in rats after permanent middle cerebral artery occlusion.
Lan X, Zhang M, Yang W, Zheng Z, Wu Y, Zeng Q, Liu S, Liu K, Li G
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2014 May;35(5):761-6
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2014 May;35(5):761-6
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 17785-1-AP(SYP antibody) at dilution of 1:1500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Synaptophysin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Synaptophysin. This antibody recognizes human,mouse,rat antigen. The Synaptophysin antibody has been validated for the following applications: ELISA, WB, IHC analysis.
