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Protein structure
BTNL2
Butyrophilin like 2BTL-II, BTN7, HSBLMHC1
This gene encodes a major histocompatibility complex, class II associated, type I transmembrane protein which belongs to the butyrophilin-like B7 family of immunoregulators. It is thought to be involved in immune surveillance, serving as a negative T-cell regulator by decreasing T-cell proliferation and cytokine release. The encoded protein contains an N-terminal signal peptide, two pairs of immunoglobulin-like domains, separated by a heptad peptide sequence, and a C-terminal transmembrane domain. Naturally occurring mutations in this gene are associated with sarcoidosis, rheumatoid arthritis, ulcerative colitis, inflammatory bowel disease, myositis, type 1 diabetes, systemic lupus erythematosus, acute coronary syndrome, and prostate cancer. [provided by RefSeq, May 2017]
Top validated antibodies |
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| Proteintech Group |  25110-1-AP |
1 references | Polyclonal |
WB
EL
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| Cusabio Biotech Co., Ltd | CSB-PA883443ESR2HU |
Polyclonal |
WB
EL
IHC
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| Invitrogen Antibodies | PA5-113451 |
Polyclonal |
WB
EL
IHC
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| LSBio | LS-C482774 |
Polyclonal |
WB
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| NovoPro Bioscience Inc. | 108549 |
Polyclonal |
WB
EL
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