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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [23]
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- Validations
- Immunohistochemistry [1]
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- Product number
- HPA037470 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA037470, RRID:AB_10672348
- Product name
- Anti-DNAH5
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human DNAH5, Gene description: dynein, axonemal, heavy chain 5, Alternative Gene Names: CILD3, Dnahc5, HL1, KTGNR, PCD, Validated applications: IHC, Uniprot ID: Q8TE73, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.3 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references CFAP65 is essential for C2a projection integrity in axonemes: implications for organ-specific ciliary dysfunction and infertility
HYDIN variants cause primary ciliary dyskinesia in the Finnish population
Next-Generation Sequencing-Based Copy Number Variation Analysis in Chinese Patients with Primary Ciliary Dyskinesia Revealed Novel DNAH5 Copy Number Variations
Characterization of pathogenic genetic variants in Russian patients with primary ciliary dyskinesia using gene panel sequencing and transcript analysis
Novel pathogenic variants of DNAH5 associated with clinical and genetic spectra of primary ciliary dyskinesia in an Arab population.
A novel mutation in PCD‐associated gene DNAAF3 causes male infertility due to asthenozoospermia
Novel Compound Heterozygous Variants in CCDC40 Associated with Primary Ciliary Dyskinesia and Multiple Morphological Abnormalities of the Sperm Flagella
CFAP300 mutation causing primary ciliary dyskinesia in Finland.
Identification of a novel founder variant in DNAI2 cause primary ciliary dyskinesia in five consanguineous families derived from a single tribe descendant of Arabian Peninsula.
Case Report: DNAAF4 Variants Cause Primary Ciliary Dyskinesia and Infertility in Two Han Chinese Families
Identification of Two Novel DNAAF2 Variants in Two Consanguineous Families with Primary Ciliary Dyskinesia
Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells
A quantitative super-resolution imaging toolbox for diagnosis of motile ciliopathies
CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module.
Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia
ZMYND10 functions in a chaperone relay during axonemal dynein assembly
Quantifying Ciliary Dynamics during Assembly Reveals Stepwise Waveform Maturation in Airway Cells
Characterization of Primary Cilia in Normal Fallopian Tube Epithelium and Serous Tubal Intraepithelial Carcinoma
Absence of CFAP69 Causes Male Infertility due to Multiple Morphological Abnormalities of the Flagella in Human and Mouse
Accuracy of Immunofluorescence in the Diagnosis of Primary Ciliary Dyskinesia
Combined exome and whole-genome sequencing identifies mutations inARMC4as a cause of primary ciliary dyskinesia with defects in the outer dynein arm
Targeted NGS gene panel identifies mutations in RSPH1 causing primary ciliary dyskinesia and a common mechanism for ciliary central pair agenesis due to radial spoke defects
HEATR2 Plays a Conserved Role in Assembly of the Ciliary Motile Apparatus
Chen J, Ren C, Zhao S, Wu H, Wang J, Dong Y, Liu S, Pan Y, Xiao Z, Yang S, Zhang J, Liu M
Cellular and Molecular Life Sciences 2025;82(1)
Cellular and Molecular Life Sciences 2025;82(1)
HYDIN variants cause primary ciliary dyskinesia in the Finnish population
Burgoyne T, Fassad M, Schultz R, Elenius V, Lim J, Freke G, Rai R, Mohammed M, Mitchison H, Sironen A
Pediatric Pulmonology 2024;59(12):3601-3609
Pediatric Pulmonology 2024;59(12):3601-3609
Next-Generation Sequencing-Based Copy Number Variation Analysis in Chinese Patients with Primary Ciliary Dyskinesia Revealed Novel DNAH5 Copy Number Variations
Chen W, Guo Z, Li M, Sheng W, Huang G
Phenomics 2024;4(1):24-33
Phenomics 2024;4(1):24-33
Characterization of pathogenic genetic variants in Russian patients with primary ciliary dyskinesia using gene panel sequencing and transcript analysis
Zlotina A, Barashkova S, Zhuk S, Skitchenko R, Usoltsev D, Sokolnikova P, Artomov M, Alekseenko S, Simanova T, Goloborodko M, Berleva O, Kostareva A
Orphanet Journal of Rare Diseases 2024;19(1)
Orphanet Journal of Rare Diseases 2024;19(1)
Novel pathogenic variants of DNAH5 associated with clinical and genetic spectra of primary ciliary dyskinesia in an Arab population.
Al-Mutairi DA, Alsabah BH, Pennekamp P, Omran H
Frontiers in genetics 2024;15:1396797
Frontiers in genetics 2024;15:1396797
A novel mutation in PCD‐associated gene DNAAF3 causes male infertility due to asthenozoospermia
Wan F, Yu L, Qu X, Xia Y, Feng K, Zhang L, Zhang N, Zhao G, Zhang C, Guo H
Journal of Cellular and Molecular Medicine 2023;27(20):3107-3116
Journal of Cellular and Molecular Medicine 2023;27(20):3107-3116
Novel Compound Heterozygous Variants in CCDC40 Associated with Primary Ciliary Dyskinesia and Multiple Morphological Abnormalities of the Sperm Flagella
Xu Y, Yang B, Lei C, Yang D, Ding S, Lu C, Wang L, Guo T, Wang R, Luo H
Pharmacogenomics and Personalized Medicine 2022;Volume 15
Pharmacogenomics and Personalized Medicine 2022;Volume 15
CFAP300 mutation causing primary ciliary dyskinesia in Finland.
Schultz R, Elenius V, Fassad MR, Freke G, Rogers A, Shoemark A, Koistinen T, Mohamed MA, Lim JSY, Mitchison HM, Sironen AI
Frontiers in genetics 2022;13:985227
Frontiers in genetics 2022;13:985227
Identification of a novel founder variant in DNAI2 cause primary ciliary dyskinesia in five consanguineous families derived from a single tribe descendant of Arabian Peninsula.
Al-Mutairi DA, Alsabah BH, Alkhaledi BA, Pennekamp P, Omran H
Frontiers in genetics 2022;13:1017280
Frontiers in genetics 2022;13:1017280
Case Report: DNAAF4 Variants Cause Primary Ciliary Dyskinesia and Infertility in Two Han Chinese Families
Guo T, Lu C, Yang D, Lei C, Liu Y, Xu Y, Yang B, Wang R, Luo H
Frontiers in Genetics 2022;13
Frontiers in Genetics 2022;13
Identification of Two Novel DNAAF2 Variants in Two Consanguineous Families with Primary Ciliary Dyskinesia
Lu C, Yang D, Lei C, Wang R, Guo T, Luo H
Pharmacogenomics and Personalized Medicine 2021;Volume 14
Pharmacogenomics and Personalized Medicine 2021;Volume 14
Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells
Hawkins F, Suzuki S, Beermann M, Barillà C, Wang R, Villacorta-Martin C, Berical A, Jean J, Le Suer J, Matte T, Simone-Roach C, Tang Y, Schlaeger T, Crane A, Matthias N, Huang S, Randell S, Wu J, Spence J, Carraro G, Stripp B, Rab A, Sorsher E, Horani A, Brody S, Davis B, Kotton D
Cell Stem Cell 2021;28(1):79-95.e8
Cell Stem Cell 2021;28(1):79-95.e8
A quantitative super-resolution imaging toolbox for diagnosis of motile ciliopathies
Liu Z, Nguyen Q, Guan Q, Albulescu A, Erdman L, Mahdaviyeh Y, Kang J, Ouyang H, Hegele R, Moraes T, Goldenberg A, Dell S, Mennella V
Science Translational Medicine 2020;12(535)
Science Translational Medicine 2020;12(535)
CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module.
Dougherty GW, Mizuno K, Nöthe-Menchen T, Ikawa Y, Boldt K, Ta-Shma A, Aprea I, Minegishi K, Pang YP, Pennekamp P, Loges NT, Raidt J, Hjeij R, Wallmeier J, Mussaffi H, Perles Z, Elpeleg O, Rabert F, Shiratori H, Letteboer SJ, Horn N, Young S, Strünker T, Stumme F, Werner C, Olbrich H, Takaoka K, Ide T, Twan WK, Biebach L, Große-Onnebrink J, Klinkenbusch JA, Praveen K, Bracht DC, Höben IM, Junger K, Gützlaff J, Cindrić S, Aviram M, Kaiser T, Memari Y, Dzeja PP, Dworniczak B, Ueffing M, Roepman R, Bartscherer K, Katsanis N, Davis EE, Amirav I, Hamada H, Omran H
Nature communications 2020 Nov 2;11(1):5520
Nature communications 2020 Nov 2;11(1):5520
Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia
Whitfield M, Thomas L, Bequignon E, Schmitt A, Stouvenel L, Montantin G, Tissier S, Duquesnoy P, Copin B, Chantot S, Dastot F, Faucon C, Barbotin A, Loyens A, Siffroi J, Papon J, Escudier E, Amselem S, Mitchell V, Touré A, Legendre M
The American Journal of Human Genetics 2019;105(1):198-212
The American Journal of Human Genetics 2019;105(1):198-212
ZMYND10 functions in a chaperone relay during axonemal dynein assembly
Mali G, Yeyati P, Mizuno S, Dodd D, Tennant P, Keighren M, zur Lage P, Shoemark A, Garcia-Munoz A, Shimada A, Takeda H, Edlich F, Takahashi S, von Kreigsheim A, Jarman A, Mill P
eLife 2018;7
eLife 2018;7
Quantifying Ciliary Dynamics during Assembly Reveals Stepwise Waveform Maturation in Airway Cells
Oltean A, Schaffer A, Bayly P, Brody S
American Journal of Respiratory Cell and Molecular Biology 2018;59(4):511-522
American Journal of Respiratory Cell and Molecular Biology 2018;59(4):511-522
Characterization of Primary Cilia in Normal Fallopian Tube Epithelium and Serous Tubal Intraepithelial Carcinoma
Abdelhamed Z, Ryan T, Fuller M, Coulson-Gilmer C, Abdelmottaleb D, Wang T, Kaun J, Wang P, Hutson R, Wilkinson N, Bell S, Johnson C
International Journal of Gynecologic Cancer 2018;28(8):1535-1544
International Journal of Gynecologic Cancer 2018;28(8):1535-1544
Absence of CFAP69 Causes Male Infertility due to Multiple Morphological Abnormalities of the Flagella in Human and Mouse
Dong F, Amiri-Yekta A, Martinez G, Saut A, Tek J, Stouvenel L, Lorès P, Karaouzène T, Thierry-Mieg N, Satre V, Brouillet S, Daneshipour A, Hosseini S, Bonhivers M, Gourabi H, Dulioust E, Arnoult C, Touré A, Ray P, Zhao H, Coutton C
The American Journal of Human Genetics 2018;102(4):636-648
The American Journal of Human Genetics 2018;102(4):636-648
Accuracy of Immunofluorescence in the Diagnosis of Primary Ciliary Dyskinesia
Shoemark A, Frost E, Dixon M, Ollosson S, Kilpin K, Patel M, Scully J, Rogers A, Mitchison H, Bush A, Hogg C
American Journal of Respiratory and Critical Care Medicine 2017;196(1):94-101
American Journal of Respiratory and Critical Care Medicine 2017;196(1):94-101
Combined exome and whole-genome sequencing identifies mutations inARMC4as a cause of primary ciliary dyskinesia with defects in the outer dynein arm
Onoufriadis A, Shoemark A, Munye M, James C, Schmidts M, Patel M, Rosser E, Bacchelli C, Beales P, Scambler P, Hart S, Danke-Roelse J, Sloper J, Hull S, Hogg C, Emes R, Pals G, Moore A, Chung E, Mitchison H
Journal of Medical Genetics 2014;51(1):61-67
Journal of Medical Genetics 2014;51(1):61-67
Targeted NGS gene panel identifies mutations in RSPH1 causing primary ciliary dyskinesia and a common mechanism for ciliary central pair agenesis due to radial spoke defects
Onoufriadis A, Shoemark A, Schmidts M, Patel M, Jimenez G, Liu H, Thomas B, Dixon M, Hirst R, Rutman A, Burgoyne T, Williams C, Scully J, Bolard F, Lafitte J, Beales P, Hogg C, Yang P, Chung E, Emes R, O'Callaghan C, Bouvagnet P, Mitchison H
Human Molecular Genetics 2014;23(13):3362-3374
Human Molecular Genetics 2014;23(13):3362-3374
HEATR2 Plays a Conserved Role in Assembly of the Ciliary Motile Apparatus
Dutcher S, Diggle C, Moore D, Mali G, zur Lage P, Ait-Lounis A, Schmidts M, Shoemark A, Garcia Munoz A, Halachev M, Gautier P, Yeyati P, Bonthron D, Carr I, Hayward B, Markham A, Hope J, von Kriegsheim A, Mitchison H, Jackson I, Durand B, Reith W, Sheridan E, Jarman A, Mill P
PLoS Genetics 2014;10(9):e1004577
PLoS Genetics 2014;10(9):e1004577
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Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Orthogonal validation
- Main image
- Experimental details
- Immunohistochemistry analysis in human fallopian tube and liver tissues using HPA037470 antibody. Corresponding DNAH5 RNA-seq data are presented for the same tissues.
- Sample type
- Human
- Protocol
- Protocol
